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1 Definition of Philadelphia chromosome - NCI
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/philadelphia-chromosome
An abnormality of chromosome 22 in which part of chromosome 9 is transferred to it. Bone marrow cells that contain the Philadelphia chromosome are often ...
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2 The legacy of the Philadelphia chromosome - PMC - NCBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934583/
The discovery of the Philadelphia chromosome as a hallmark of chronic myelogenous leukemia in 1960 by Peter Nowell provided evidence for a genetic link to ...
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3 Philadelphia Chromosome - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/philadelphia-chromosome
The Philadelphia chromosome was the first recurrent genetic alteration found to be associated with a specific human cancer, chronic myeloid leukemia (CML). It ...
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4 The Philadelphia Chromosome: History and Implications for ...
https://www.foxchase.org/about-us/history/discoveries-fox-chase-research/philadelphia-chromosome/philadelphia-chromosome
The abnormally shortened chromosome was discovered by both Hungerford, of the Fox Chase Cancer Center, and Nowell of the University of Pennsylvania, and was ...
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5 Philadelphia chromosome - Wikipedia
https://en.wikipedia.org/wiki/Philadelphia_chromosome
The Philadelphia chromosome or Philadelphia translocation (Ph) is a specific genetic abnormality in chromosome 22 of leukemia cancer cells (particularly ...
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6 Overview of the Philadelphia Chromosome - Verywell Health
https://www.verywellhealth.com/what-is-the-philadelphia-chromosome-2252562
The Philadelphia chromosome is a specific finding in the genes of a person's white blood cells—a finding that has implications for leukemia.
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7 Medical Definition of Philadelphia chromosome (Ph) - RxList
https://www.rxlist.com/philadelphia_chromosome_ph/definition.htm
The Philadelphia (Ph) chromosome is an abbreviated chromosome 22 that was shortchanged in a reciprocal exchange of material with chromosome 9. This ...
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8 Philadelphia chromosome-positive chronic myeloid leukemia
https://www.medicalnewstoday.com/articles/philadelphia-chromosome-positive-chronic-myeloid-leukemia
The Philadelphia chromosome is one of these mistakes. It occurs when pieces of two different chromosomes swap places. This happens with parts of ...
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9 What You Need to Know about Philadelphia Chromosome ALL
https://www.healthline.com/health/leukemia/philadelphia-chromosome-all
The Philadelphia chromosome is a shortened version of chromosome 22Trusted Source . It forms when a gene generally found on chromosome 9 called ...
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10 Treatment and monitoring of Philadelphia chromosome ...
https://jhoonline.biomedcentral.com/articles/10.1186/s13045-019-0729-2
The Philadelphia (Ph) chromosome, resulting from the t(9;22)(q34;q11) translocation, can be found in chronic myeloid leukemia (CML) as well ...
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11 What Causes Chronic Myeloid Leukemia?
https://www.cancer.org/cancer/chronic-myeloid-leukemia/causes-risks-prevention/what-causes.html
In a very small number of CML patients, the leukemia cells have the BCR-ABL oncogene but not the Philadelphia chromosome. It's thought that the ...
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12 Philadelphia chromosome–like acute lymphoblastic leukemia
https://ashpublications.org/blood/article/130/19/2064/36686/Philadelphia-chromosome-like-acute-lymphoblastic
Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), also referred to as BCR-ABL1–like ALL, is a high-risk subset with a gene expression ...
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13 Clinical Significance of the Philadelphia Chromosome in ...
https://www.acpjournals.org/doi/10.7326/0003-4819-68-5-1166_2
The Philadelphia (Ph1) chromosome in chronic granulocytic leukemia (CGL) is the only specific cytogenetic defect in human neoplastic disease.
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14 The Philadelphia Chromosome: A Genetic Mystery, a Lethal ...
https://www.amazon.com/Philadelphia-Chromosome-Improbable-Invention-Lifesaving/dp/1615191976
In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be ...
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15 Philadelphia Chromosome–Positive Acute Lymphoblastic ...
https://www.nejm.org/doi/full/10.1056/NEJMra2113347
The Philadelphia chromosome (Ph) was the first cytogenetic abnormality associated with a human cancer, chronic myeloid leukemia (CML).
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16 Philadelphia chromosome definition
https://groups.molbiosci.northwestern.edu/holmgren/Glossary/Definitions/Def-P/Philadelphia_chromosome.html
A translocation between the long arms of chromosomes 9 and 22, often found in the white blood cells of patients with chronic myeloid leukemia.
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17 Clinical and prognostic significance of the Philadelphia ...
https://link.springer.com/article/10.1007/BF01715353
Between 1983 and 1991 the Philadelphia chromosome (Ph1) was found in bone marrow and/or peripheral blood cells of 25 adult patients with acute lymphoblastic ...
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18 Research of the Philadelphia Chromosome in Chronic ...
https://www.intechopen.com/chapters/75070
In summary, Philadelphia chromosome is an abnormal chromosome 22, resulting from a reciprocal translocation between chromosomes 9 and 22, a specific marker in ...
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19 The Philadelphia Chromosome | OncoLink
https://www.oncolink.org/cancers/blood-cancers/chronic-myelogenous-leukemia-cml/the-philadelphia-chromosome
The Philadelphia Chromosome ... Drs. Peter Nowell and David Hungerford, two Philadelphia researchers, were experimenting with cells from various types of leukemia ...
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20 Primary Philadelphia chromosome positive acute myeloid ...
https://journals.lww.com/md-journal/fulltext/2018/11020/primary_philadelphia_chromosome_positive_acute.23.aspx
Philadelphia chromosome is the result of a reciprocal translocation involving the long arms of chromosomes 9 and 22, referred to as t (9; 22) (q34; q11). A ...
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21 Philadelphia Chromosome–Positive Acute Lymphoblastic ...
https://www.hematologyandoncology.net/archives/march-2018/philadelphia-chromosome-positive-acute-lymphoblastic-leukemia-in-adults-current-treatments-and-future-perspectives/
Abstract: Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL) accounts for approximately one-fourth of cases of adult ALL.
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22 Philadelphia Chromosome, Translocations, Inversions ...
https://www.youtube.com/watch?v=maqL26dJ0vM
PhysioPathoPharmaco
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23 Philadelphia chromosome :: CSHL DNA Learning Center
https://dnalc.cshl.edu/view/15706-Philadelphia-chromosome.html
The Philadelphia chromosome is an abnormal chromosome that results from the exchange of portions of genetic material from chromosomes 9 and 22.
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24 Philadelphia chromosome | genetics | Britannica
https://www.britannica.com/science/Philadelphia-chromosome
Other articles where Philadelphia chromosome is discussed: blood disease: Leukemia: …abnormality of this type, the Philadelphia chromosome, occurs in almost ...
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25 Chronic Myeloid Leukemia (CML) - Penn Medicine
https://www.pennmedicine.org/cancer/types-of-cancer/leukemia/types-of-leukemia/chronic-myeloid-leukemia
No one is born with the Philadelphia chromosome; rather it is a result of a genetic accident that happens in a blood-forming stem cell in the bone marrow. It is ...
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26 Prognostic implications of additional genomic lesions in adult ...
https://www.haematologica.org/article/view/8774
These results indicate that in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia a detailed evaluation of additional ...
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27 Genetics, Philadelphia Chromosome Article - StatPearls
https://www.statpearls.com/articlelibrary/viewarticle/114117/
[17] This pathway controls cell survival, proliferation, cell cycle arrest, and has gained importance for pharmacological intervention over the ...
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28 Creation of Philadelphia chromosome by CRISPR/Cas9 ...
https://www.nature.com/articles/s41417-022-00522-w
The Philadelphia (Ph) chromosome was the first translocation identified in leukemia. It is supposed to be generated by aberrant ligation ...
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29 Philadelphia Chromosome Negative Myeloproliferative ...
https://www.panfoundation.org/disease-funds/philadelphia-chromosome-negative-myeloproliferative-neoplasms/
Philadelphia chromosome negative myeloproliferative neoplasms (MPN) is a cancer associated with increased production of blood cells.
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30 Philadelphia chromosome Definition & Meaning
https://www.merriam-webster.com/medical/Philadelphia%20chromosome
The meaning of PHILADELPHIA CHROMOSOME is an abnormally short chromosome 22 that is found in the hematopoietic cells of persons affected with chronic ...
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31 Philadelphia Chromosome-positive Acute Lymphoblastic ...
https://aacrjournals.org/cancerres/article/48/10/2876/492574/Philadelphia-Chromosome-positive-Acute
The Philadelphia (Ph) chromosome translocation which is classically observed in chronic myeloid leukemia (CML) is sporadically found in acute lymphoblastic ...
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32 BCR ABL Genetic Test: MedlinePlus Medical Test
https://medlineplus.gov/lab-tests/bcr-abl-genetic-test/
The changed chromosome 22, which contains the BCR-ABL gene, is called the Philadelphia chromosome because that's the city where researchers ...
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33 What Is the Role of HSCT in Philadelphia-Chromosome ...
https://www.frontiersin.org/articles/10.3389/fped.2021.807002/full
Philadelphia-chromosome–positive (Ph+) acute lymphoblastic leukaemia (ALL) and, more recently, also Philadelphia-chromosome–like (Ph-like; also known as BCR-ABL ...
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34 Clinical significance of Philadelphia chromosome positive ...
https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/(SICI)1097-0142(19981101)83:9%3C2030::AID-CNCR21%3E3.0.CO%3B2-Q
Children with Philadelphia (Ph) chromosome positive (+) acute lymphoblastic leukemia (ALL) represent a subgroup at very high risk for treatment ...
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35 A Unique Three-Way Variant Philadelphia Chromosome t(6;9
https://www.dovepress.com/a-unique-three-way-variant-philadelphia-chromosome-t6922p213q34q112-in-peer-reviewed-fulltext-article-OTT
It is characterized by the presence of a translocation between chromosomes 9 and 22, t(9;22)(q34;q11), known as the Philadelphia (Ph) chromosome ...
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36 P190 BCR-ABL1 in a Patient with Philadelphia Chromosome ...
https://www.karger.com/Article/FullText/516270
Philadelphia chromosome positive (Ph+) is the most common cytogenetic abnormality in chronic myeloid leukemia (CML) and B-acute lymphoblastic leukemia (B-ALL).
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37 Study of Chinese Newly Diagnosed Participants With ...
https://clinicaltrials.gov/ct2/show/NCT03509896
Chronic Myeloid Leukemia Philadelphia Chromosome Chronic Myeloid Leukemia in ... Choosing to participate in a study is an important personal decision.
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38 Analysis of Philadelphia chromosome-negative BCR-ABL ...
https://www.annalsofoncology.org/article/S0923-7534(19)57311-2/pdf
Therefore, HMF provides a precise estimate of small but significant changes in the fre- quency of Ph-positive cells in CML, which would be important for ...
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39 Comprehensive molecular characterization of a rare case of ...
http://molecularcasestudies.cshlp.org/content/8/6/a006218.full
Philadelphia chromosome-positive acute myeloid leukemia (Ph+ AML) is a rare disease that is not well-understood nor does it present with clearly defined ...
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40 Philadelphia chromosome in eosinophilic leukemia
https://www.amjmed.com/article/0002-9343(65)90123-3/fulltext
Clinical and cytogenetic findings in a patient with eosinophilic leukemia are presented. The Philadelphia (Ph 1) chromosome was found in 88.2 per cent of ...
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41 A rare case of Acute Lymphocytic Leukemia (ALL) presenting ...
https://www.scielo.br/j/gmb/a/TynJqBx3brXXYQdv7GXMJ6x/?lang=en
The Philadelphia chromosome is observed in 5% of pediatric acute lymphocytic leukemia (ALL) and in 25% to 50% of adult ALL cases, and is associated with ...
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42 David Hungerford and the Philadelphia Chromosome
https://cancerhistoryproject.com/people/david-hungerford-and-the-philadelphia-chromosome/
The Philadelphia chromosome became an important tool for diagnosing CML and monitoring treatment. More importantly, the linking of culprit genes with ...
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43 What Is Philadelphia Chromosome Positive ALL?
https://www.stbaldricks.org/blog/post/what-is-philadelphia-chromosome-positive-all/
Philadelphia Chromosome positive acute lymphoblastic leukemia (Ph+ALL) is a rare subtype of the most common childhood cancer, ...
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44 Philadelphia Chromosome-Positive Leukemia in the ... - MDPI
https://www.mdpi.com/1422-0067/21/16/5776
Philadelphia chromosome (Ph) results from a translocation between the breakpoint cluster region (BCR) gene on chromosome 9 and ABL proto-oncogene 1 (ABL1) ...
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45 Philadelphia chromosome-positive acute lymphoblastic ...
https://apm.amegroups.com/article/view/51949/html
Besides, Philadelphia chromosome-positive represents the most unfavorable prognosis among leukemia, which increases with age. Research shows that the incidence ...
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46 Unique fusion of bcr and c-abl genes in Philadelphia ...
https://www.cell.com/abstract/0092-8674(87)90007-9
The Philadelphia (Ph) chromosome, the product of t(9:22), is the cytogenetic hallmark of chronic myelogenous leukemia. The c-abl oncogene on chromosome 9 is ...
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47 The prognostic significance of additional cytogenetic ...
https://www.clinical-lymphoma-myeloma-leukemia.com/article/S2152-2650(15)00170-6/fulltext
Philadelphia chromosome (Ph) is the most common cytogenetic abnormality in adult ALL. Ph+ ALL has poor prognosis and allogeneic hematopoietic stem cell ...
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48 Treatment of Philadelphia chromosome-positive acute ...
https://www.tandfonline.com/doi/full/10.3109/10428190903370395
The presence of the Philadelphia chromosome is a poor prognosis factor in acute lymphoblastic leukemia (ALL), in both children and adults.
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49 Philadelphia Chromosome Positive Acute Lymphoblastic ...
https://massivebio.com/philadelphia-chromosome-positive-acute-lymphoblastic-leukemia/
Philadelphia Chromosome positive acute lymphoblastic leukemia (Ph+ALL) is a rare subtype of the most common childhood cancer, acute ...
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50 Ph-Positive ALL Therapy | Leukemia and Lymphoma Society
https://www.lls.org/leukemia/acute-lymphoblastic-leukemia/treatment/ph-positive-all-therapy
The abnormal chromosome 22 is known as the Philadelphia chromosome. This chromosomal alteration creates a fusion gene called BCR-ABL1. This gene produces a ...
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51 Interphase FISH for Follow-up of Philadelphia Chromosome
https://ar.iiarjournals.org/content/anticanres/24/4/2535.full.pdf
However, interferon alfa and imatinib induce bone marrow hypoplasia in a significant number of patients. Therefore, a sufficient number of metaphases is ...
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52 Dual Rearrangement of Immunoglobulin and T-cell Receptor ...
https://academic.oup.com/jjco/article/28/6/396/807622
The marrow cells had Philadelphia chromosome with no additional abnormalities. Major bcr-abl fusion gene was observed by the reverse ...
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53 Understanding Ph+ Chronic Myeloid Leukemia - Sprycel
https://www.sprycel.com/understanding-treatment
View Transcript Close Transcript. Philadelphia chromosome-positive chronic myeloid leukemia, or Ph+ CML, is a kind of leukemia or cancer of the blood. To help ...
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54 BCR-ABL1 Test - Testing.com
https://www.testing.com/tests/bcr-abl1/
The resulting Philadelphia chromosome contains an abnormal BCR-ABL1 fusion gene that encodes an abnormal protein that is responsible for the ...
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55 Clinical trial puts Philadelphia chromosome-positive leukemia ...
https://www.mdanderson.org/cancerwise/immunotherapy-and-targeted-therapy-clinical-trial-put-philadelphelphia-chromosome-positive-acute-lymphoblastic-leukemia-ALL-patient-in-remission.h00-159461634.html
When a genetic test revealed that Jorge Castillo had a particularly aggressive type of acute lymphoblastic leukemia called Philadelphia ...
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56 Induction therapy for Philadelphia chromosome positive acute ...
https://www.uptodate.com/contents/induction-therapy-for-philadelphia-chromosome-positive-acute-lymphoblastic-leukemia-in-adults
Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) is a biologically and clinically distinct entity classified as ALL ...
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57 Targeting BCL-2 and ABL/LYN in Philadelphia chromosome ...
https://www.science.org/doi/10.1126/scitranslmed.aaf5309
Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ALL) carries the BCR-ABL translocation; however, despite the existence of drugs that ...
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58 Philadelphia chromosome with acute myeloid leukemia and ...
https://www.spandidos-publications.com/10.3892/ol.2017.5578
The Philadelphia chromosome (Ph) or breakpoint cluster region-Abelson (BCR-ABL) fusion gene is more common in patients with chronic myelogenous ...
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59 The Clinical Significance of BCR-ABL1 Mutations in Patients ...
https://www.astctjournal.org/article/S2666-6367(22)00156-7/fulltext
Drug resistance and BCR-ABL kinase domain mutations in Philadelphia chromosome-positive acute lymphoblastic leukemia from the imatinib to the ...
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60 definition of Philadelphia chromosome by Medical dictionary
https://medical-dictionary.thefreedictionary.com/Philadelphia+chromosome
Ph1 chromosome (Philadelphia chromosome) an abnormality of chromosome 22, characterized by the translocation of genetic material from its long arm to chromosome ...
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61 Philadelphia chromosome - wikidoc
https://www.wikidoc.org/index.php/Philadelphia_chromosome
The Philadelphia chromosome was first discovered and described in 1960 by Peter Nowell from University of Pennsylvania School of Medicine and ...
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62 Is Philadelphia Chromosome Curable? - eMedicineHealth
https://www.emedicinehealth.com/is_philadelphia_chromosome_curable/article_em.htm
Philadelphia chromosome is a genetic mutation that causes leukemia. There is technically no cure for chronic myeloid leukemia (CML) ...
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63 Patient preferences for frontline therapies for Philadelphia ...
https://www.futuremedicine.com/doi/10.2217/fon-2022-0082
Results: Although OS was the most important attribute to patients with Ph+ ... Philadelphia chromosome-positive acute lymphoblastic leukemia ...
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64 Chronic Myelogenous Leukemia (CML) - Medscape Reference
https://emedicine.medscape.com/article/199425-overview
Philadelphia chromosome (Ph1) in bone marrow cells ... and other drugs in this category are playing increasingly important roles.
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65 Molecular Monitoring in Adult Philadelphia Chromosome ...
https://www.hindawi.com/journals/crihem/2019/9635070/
Monitoring BCR-ABL1 transcript levels in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is a widely adopted method to ...
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66 Reprogramming of primary human Philadelphia chromosome ...
https://www.pnas.org/doi/10.1073/pnas.1413383112
Significance. Precursor B cell acute lymphoblastic leukemia (B-ALL) is an aggressive cancer of white blood cells with a poor prognosis. The cancerous cells in ...
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67 Philadelphia chromosome - Wiktionary
https://en.wiktionary.org/wiki/Philadelphia_chromosome
› wiki › Philadelphia_chromo...
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68 European Commission Approves Asciminib in Philadelphia ...
https://www.cancernetwork.com/view/european-commission-approves-asciminib-in-philadelphia-chromosome-positive-cml
... European Commission for patients with Philadelphia chromosome–positive ... and those experiencing significant [adverse] effects [AEs] or ...
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69 Effect of Dasatinib vs Imatinib in the Treatment of Pediatric ...
https://jamanetwork.com/journals/jamaoncology/fullarticle/2758575
Meaning These findings support the use of dasatinib at a dosage of 80 mg/m2 per day in children with Philadelphia chromosome–positive acute ...
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70 PHLDF - Overview: Philadelphia Chromosome-like Acute ...
https://www.mayocliniclabs.com/test-catalog/overview/609577
Detecting a neoplastic clone associated with Philadelphia chromosome-like acute lymphoblastic leukemia (ALL), particularly when a classic ...
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71 An Unusual Case of Philadelphia Chromosome–Positive ...
https://meridian.allenpress.com/aplm/article/137/8/1147/65515/An-Unusual-Case-of-Philadelphia-Chromosome
Initial identification of chronic myelogenous leukemia is very important since targeted therapy leads to life-saving remission.
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72 Fusion genes and cancer cures: The story of the Philadelphia ...
https://geneticsunzipped.com/transcripts/2020/10/7/fusion-genes-and-cancer-cures-the-story-of-the-philadelphia-chromosome
Eventually, researchers around the globe confirmed their findings, and we now know that 95% of CML patients have the Philadelphia chromosome ...
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73 Book Review: The Philadelphia Chromosome - WSJ
https://www.wsj.com/articles/SB10001424127887324188604578543702251247868
More than 50 years ago, scientists working in the City of Brotherly Love discovered a genetic mutation that they called "the Philadelphia ...
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74 Philadelphia chromosome linked to leukaemia variety and ...
https://www.pharmaceutical-technology.com/comment/treatment-options-for-philadelphia-chromosome-positive-leukaemia/
Philadelphia chromosome: Ph contains the BCR-ABL fusion gene, which is the underlying cause of most chronic myelogenous leukaemia (CML) ...
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75 Are occupational, hobby, or lifestyle exposures associated ...
https://oem.bmj.com/content/58/11/722
OBJECTIVES To investigate a broad range of occupational, hobby, and lifestyle exposures, suggested as risk factors for Philadelphia chromosome positive ...
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76 The Philadelphia Chromosome - The Experiment Publishing
https://theexperimentpublishing.com/catalogs/spring-2014/the-philadelphia-chromosome/
Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA.
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77 When the Philadelphia Chromosome Strikes
https://strandls.com/philadelphia-chromosome-strikes/
The BCR-ABL1 mutation also known as the Philadelphia chromosome or Philadelphia translocation (Ph) is a genetic abnormality in chromosome 22. There is a ...
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78 Acute Myeloid Leukemia with Philadelphia Chromosome ...
https://www.cureus.com/articles/21700-acute-myeloid-leukemia-with-philadelphia-chromosome-near-tetraploidy-and-5q-deletion
Karyotyping returned positive for the BCR-ABL1 fusion gene (Philadelphia chromosome), near-tetraploidy, and 5q deletion. Follow-up bone marrow ...
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79 Object 34: Philadelphia chromosome
https://www.rcpath.org/uploads/assets/7c4228a1-dda6-4328-b8fe4c2084beb54a/34-Philadelphia-Chromosome.pdf
The Philadelphia chromosome is an abnormal chromosome 22, ... Learn more about Howell and Hungerford's discovery and its significance on the Penn.
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80 Co-Discoverer of the Philadelphia Chromosome, Peter Nowell ...
https://ascopost.com/issues/february-10-2017/co-discoverer-of-the-philadelphia-chromosome-peter-nowell-md-dies/
The seminal observation was made that certain leukemia cells had an abnormally short chromosome 22. In 1959, that mutation was described as the ...
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81 Double Philadelphia Chromosome-Positive B Acute ...
https://www.ommegaonline.org/article-details/Double-Philadelphia-Chromosome-Positive-B-Acute-Lymphoblastic-Leukemia/1900
Ph chromosome positive ALL is associated with a highly aggressive disease, more resistant to chemotherapy[2], and lower remission rate and ...
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82 (PDF) Detection of Philadelphia Chromosome in Patients with ...
https://www.researchgate.net/publication/5545146_Detection_of_Philadelphia_Chromosome_in_Patients_with_Chronic_Myeloid_Leukemia_from_the_Presov_Region_in_Slovakia_1995-2004
PDF | Philadelphia chromosome (Ph) is a characteristic chromosomal marker that is associated with chronic myelogenous leukemia (CML).
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83 Ph+ Chronic Myeloid Leukemia (CML) Glossary of Terms
https://www.us.tasigna.com/patient-support/glossary/
Cytogenetic testing: Tests done on bone marrow cells or white blood cells to see if they contain the Philadelphia chromosome. Deep molecular response (DMR): ...
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84 Prognostic significance of additional cytogenetic abnormalities ...
https://vivo.weill.cornell.edu/display/pubid3164637
Of 661 patients with Philadelphia chromosome (Ph)-positive, nonblastic chronic granulocytic leukemia, 58 had cytogenetic abnormalities in ...
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85 From the Philadelphia chromosome to the cytoskeleton
https://repository.upenn.edu/dissertations/AAI3073071/
Chronic myelogenous leukemia (CML) is a biphasic neoplasm of the bone marrow that is precipitated by the Philadelphia Chromosome, a t(9;22) balanced ...
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86 Targeted Therapies for Philadelphia Chromosome-Positive ...
https://www.uspharmacist.com/article/targeted-therapies-for-philadelphia-chromosome-positive-acute-lymphoblastic-leukemia
ABSTRACT: The Philadelphia chromosome (Ph) is a cytogenetic abnormality commonly seen in adult patients with acute lymphoblastic leukemia ...
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87 The Philadelphia Chromosome - Workman Publishing
https://www.workman.com/products/the-philadelphia-chromosome/paperback
In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer ...
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88 Philadephia – the birthplace of cancer genetics
https://scifundchallenge.org/firesidescience/2013/11/11/philadephia-the-birthplace-of-cancer-genetics/
There's one abnormal chromosome we still refer to by the town where it was discovered – the Philadelphia Chromosome. It has a remarkable history ...
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89 What is the Philadelphia Chromosome?
https://www.wise-geek.com/what-is-the-philadelphia-chromosome.htm
The Philadelphia chromosome is a chromosomal abnormality that can lead to leukemia. People with the Philadelphia chromosome tend...
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90 what is the philadelphia chromosome? how is this ... - Numerade
https://www.numerade.com/ask/question/what-is-the-philadelphia-chromosome-how-is-this-chromosome-related-to-cancer-identify-how-this-chromosome-appears-physically-different-on-a-karyotype-than-it-appears-on-a-karyotype-of-normal-01068/
So this piece of chromosome 22 will be attached chromosome nine And this piece of chromosome nine is then attached to chromosome 22. And so this ...
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91 Chromosomal Abnormalities and Genetic Alterations in CML
https://www.onclive.com/view/chromosomal-abnormalities-and-genetic-alterations-in-cml
The gene known as ABL, coming from the Abelson leukemia virus, is relocated from chromosome 9 to 22, where it is a juxtaposition to another gene ...
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92 Phase 3 Trial of ICLUSIG ® (ponatinib) Met Primary Endpoint ...
https://www.takeda.com/newsroom/newsreleases/2022/phase-3-trial-of-iclusig-ponatinib-met-primary-efficacy-endpoint/
About Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) ... Ph+ ALL is a rare form of ALL that affects approximately 25% of ...
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93 ABL1 | Cancer Genetics Web - CancerIndex
http://www.cancerindex.org/geneweb/ABL1.htm
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a recently identified high-risk subtype of B-lineage ALL (B-ALL), characterized by a ...
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94 Ponatinib Produces Higher Rates of Minimal Residual ...
https://www.pharmacytimes.com/view/ponatinib-produces-higher-rates-of-minimal-residual-disease-negative-complete-remission-in-ph-all
... minimal residual disease-negative complete remission rates in adult patients with newly diagnosed Philadelphia chromosome-positive acute ...
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95 Philadelphia Chromosome Importance in the oncologic ...
https://slideplayer.com/slide/1633929/
Introduction Philadelphia chromosome (Ph) Discovered in 1960 by Peter C. Nowel and David Hungerford; First oncological gene documented; ...
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96 In Ph+ALL, Takeda's Iclusig outdoes Novartis' Imatinib in trial
https://www.fiercepharma.com/pharma/takedas-iclusig-tops-chemotherapy-philadelphia-chromosome-all
... Philadelphia-chromosome-positive acute lymphoblastic leukemia (Ph+ALL). ... where she'll fill the newly-minted role of chief commercial officer.
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