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1 Organic osmolytes in acute hyponatremia - PubMed
https://pubmed.ncbi.nlm.nih.gov/8498536/
It is concluded that: most of the change of brain osmolality in chronic hyponatremia can be accounted by the changes in organic osmolytes and brain electrolytes ...
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2 Rapid (24-Hour) Reaccumulation of Brain Organic Osmolytes ...
https://jasn.asnjournals.org/content/13/6/1433
Depletion of brain osmolytes during adaptation to chronic hyponatremia makes the brain vulnerable to injury when the hyponatremia is corrected.
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3 Effects of dilutional hyponatremia on brain ... - AASLD Journals
https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.20237
The aim of this study was to determine the effects of hyponatremia on brain organic osmolytes and brain water content in cirrhosis.
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4 Role of organic osmolytes in myelinolysis. A topographic study ...
https://www.jci.org/articles/view/117831
Myoinositol, glycerophosphorylcholine, glycerophosphorylethanolamine, and creatine were distributed more evenly. In chronic hyponatremic rats (plasma Na 110 +/- ...
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5 Hyponatremia causes large sustained reductions in brain ...
https://www.sciencedirect.com/science/article/pii/0006899391908067/pdf?md5=2bafcb02211a1e4cd4db6dece83f29e6&pid=1-s2.0-0006899391908067-main.pdf
rats after 2, 7 and 14 d of sustained hyponatremia induced by continuous ... and brain electrolyte and most organic osmolyte contents then remained at these ...
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6 Organic osmolytes in hyponatremia and ammonia toxicity
https://link.springer.com/article/10.1007/s11011-010-9170-5
Organic osmolytes are subsequently extruded to preserve brain cell function and allow brain volume to return to normal, whereas ammonia causes a ...
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7 Organic osmolytes in hyponatremia and ammonia toxicity
https://www.researchgate.net/publication/41657801_Organic_osmolytes_in_hyponatremia_and_ammonia_toxicity
Request PDF | Organic osmolytes in hyponatremia and ammonia toxicity | Hyperammonemia (HA) is a major and commonly observed feature of hepatic ...
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8 Organic osmolytes in hyponatremia and ammonia toxicity
https://hero.epa.gov/hero/index.cfm/reference/details/reference_id/990670
Both conditions have some features in common, such as the release of organic osmolytes, which might be an adaptive mechanism against cell swelling. However, the ...
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9 Hyponatremia causes large sustained reductions ... - Read by QxMD
https://read.qxmd.com/read/1817731/hyponatremia-causes-large-sustained-reductions-in-brain-content-of-multiple-organic-osmolytes-in-rats
Brain Na+, K+ and Cl- and multiple organic osmolytes (glutamate, ... by 2 d of hyponatremia, and brain electrolyte and most organic osmolyte contents then ...
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10 Study of brain electrolytes and organic osmolytes during ...
https://europepmc.org/article/pmc/296033
Osmotic injury induced by rapid correction of severe chronic hyponatremia has been implicated in the development of central pontine myelinolysis. Organic ...
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11 Organic Osmolytes in the Brain of an Infant with Hypernatremia
https://www.nejm.org/doi/full/10.1056/nejm199408183310704
... as do a majority of patients with hyponatremia (plasma sodium ... Osmoles (or osmolytes) are volume-regulatory organic solutes that can ...
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12 [PDF] Study of brain electrolytes and organic osmolytes during ...
https://www.semanticscholar.org/paper/Study-of-brain-electrolytes-and-organic-osmolytes-Lien-Shapiro/dd577a2bf9e48adc1340da252e31dc8e8136611d
Most of the change of brain osmolality in chronic hyponatremia can be accounted for by the changes in organic osmolytes and brain ...
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13 Acute and Chronic Hyponatremia - Frontiers
https://www.frontiersin.org/articles/10.3389/fmed.2021.693738/full
In chronic hyponatremia (>48 h), the losses of both electrolytes and organic osmolytes (e.g., myoinositol, betaine, glutamine, taurine, and g- ...
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14 Brain Volume Regulation in Response to Hypo-osmolality and ...
http://www.ihrdni.org/306-114-1.pdf
severe hyponatremia is critically dependent on the loss of organic osmolytes from brain cells. These intracellular, osmotically active solutes contribute ...
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15 Mechanisms Counteracting Swelling in Brain Cells During ...
https://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1179&context=vetscipapers
Electrolytes and organic osmolyte content in rat brain during chronic hyponatremia. Osmolyte (nmol/kg DBW)a. Normonatremic. Hyponatremic.
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16 PRIME PubMed | Effects of dilutional hyponatremia on brain organic ...
https://safeaccess.unboundmedicine.com/medline/citation/15185302/Effects_of_dilutional_hyponatremia_on_brain_organic_osmolytes_and_water_content_in_patients_with_cirrhosis_
In advanced cirrhosis there is a reduction in the brain concentration of many organic osmolytes, particularly myo-inositol (MI). Hyponatremia could ...
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17 Hyponatremia causes large sustained reductions in brain ... - Wikidata
https://www.wikidata.org/wiki/Q46166436
Hyponatremia causes large sustained reductions in brain content of multiple organic osmolytes in rats. (English). 1 reference.
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18 Effects of dilutional hyponatremia on brain organic osmolytes ...
https://ocul-gue.primo.exlibrisgroup.com/discovery/openurl?institution=01OCUL_GUE&rfr_id=info:sid%252Fprimo.exlibrisgroup.com-bX-Bx&rft_val_fmt=info:ofi/fmt:kev:mtx:&rft.epage=22&rft.volume=39&rft_id=info:doi/&rfr_id=info:sid/primo.exlibrisgroup.com-18540210-Bx&rft.isbn_list=&rft.jtitle=Hepatology&rft.genre=article&rft.issue=6&rft.auinit1=T&rft.aulast=Restuccia&rft.auinit=T&rft.date=2004&rft.eisbn_list=&rft.spage=1613&rft.au=Restuccia,%20Tea&rft.atitle=Effects%20of%20dilutional%20hyponatremia%20on%20brain%20organic%20osmolytes%20and%20water%20content%20in%20patients%20with%20cirrhosis&rft.issn=0270-9139&svc_dat=CTO&vid=01OCUL_GUE:GUELPH
Effects of dilutional hyponatremia on brain organic osmolytes and water content in patients with cirrhosis-article.
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19 Effects of Hyponatremia on the Brain - MDPI
https://www.mdpi.com/2077-0383/3/4/1163
The efflux of organic osmolytes is sustained as long as hyponatremia persists, becoming an essential adaptive mechanism in chronic hyponatremia.
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20 Hyponatremia and the Brain - Kidney International Reports
https://www.kireports.org/article/S2468-0249(17)30373-X/fulltext
During acute hyponatremia, when brain electrolyte content has reached its maximal point of depletion (∼18%), and if organic osmolyte extrusion ...
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21 US5182299A - Treatment of osmotic disturbance with organic ...
https://patents.google.com/patent/US5182299A/en
Also included are precursors of organic osmolytes including precursors of ... Hypoosmolality or hyponatremia is the most common disorder of body fluid and ...
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22 Uremia Preventing Osmotic Demyelination Syndrome Despite ...
https://journals.sagepub.com/doi/pdf/10.1177/2324709620918095
central pontine myelinolysis from rapid hyponatremia cor- rection, was first described by ... which is followed by a delayed efflux of organic osmolytes.
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23 Namrata Parikh on Twitter: "19/22 To quote Dr Sterns - Twitter
https://twitter.com/namratayparikh/status/1261315456054333441?lang=en
9/22 In hyponatremia, the ECF Na is low Possible causes (which have eluded physicians since ... Then, they throw out organic osmolytes like glutamate ...
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24 Myoinositol Administration Improves Survival and Reduces ...
https://academic.oup.com/jnen/article-pdf/65/1/37/8276601/65-1-37.pdf
When chronic hyponatremia is rapidly corrected, reaccumulation of brain organic osmolytes is delayed and brain cell shrinkage occurs, leading to the osmotic ...
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25 Does 'asymptomatic hyponatremia' exist? - Nature
https://www.nature.com/articles/nrneph.2010.21
Among the extruded organic osmolytes are glutamate, taurine, myo-inositol, glutamine, and creatine. Although it must be emphasized that glutaminergic ...
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26 Osmolytes : Current Opinion in Nephrology and Hypertension
https://journals.lww.com/co-nephrolhypertens/abstract/1992/10000/osmolytes.7.aspx
The major organic osmolytes are glycerophosphorylcholine, betaine, myo-inositol, sorbitol, and, possibly, taurine. When the concentrations of poorly ...
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27 treatment of osmotic disturbance with organic osmolytes
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO1991014435
A method for treating osmotic disturbances such as hypernatremia and hyponatremia comprising parenteral or enteral administration of an effective amount of ...
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28 Pediatric Hyponatremia - emedicine - Medscape Reference
https://emedicine.medscape.com/article/907841-overview
Hyponatremia is defined as serum sodium (Na) concentration of less than 135 ... In addition, inorganic osmolytes and organic osmolytes (eg, ...
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29 Hyponatremia and the Brain - ULB
https://dipot.ulb.ac.be/dspace/bitstream/2013/296776/1/doi_280420.pdf
hyponatremia on the brain are seen when serum sodium concentration decreases in a ... electrolytes and nonelectrolyte or organic osmolytes.
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30 Urea minimizes brain complications following rapid correction ...
https://www.kidney-international.org/article/S0085-2538(15)30054-5/pdf
During chronic hyponatremia, a significant decrease in the content of brain organic osmolyte contributes to the osmotic buffering of the ...
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31 Allostasis and the Clinical Manifestations of Mild to Moderate ...
https://www.ajkd.org/article/S0272-6386(18)31084-9/pdf
The brain's adaptation to severe hyponatremia (serum sodium < 120 mEq/L) has ... changes in their volume, cells export organic osmolytes.
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32 Hypertonicity: Pathophysiologic Concept and Experimental ...
https://hsrc.himmelfarb.gwu.edu/cgi/viewcontent.cgi?referer=&httpsredir=1&article=1751&context=smhs_medicine_facpubs
FIGURE 3: Time course of brain organic osmolytes in hypertonicity. ... the stage of correction of experimental chronic hyponatremia [36].
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33 Current perspectives in the management of hyponatremia
https://www.tandfonline.com/doi/pdf/10.1586/14737175.7.12.1791
The clinical scenario is typically one of chronic hyponatremia followed by a rapid ... Within approximately 48 h, loss of brain organic osmolytes per-.
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34 Treatment of Symptomatic Hyponatremia
https://www.amjmedsci.com/article/S0002-9629(15)34251-8/abstract
In patients with asymptomatic hyponatremia, slow correction is the appropriate ... This property of urea, facilitating brain organic osmolyte accumulation, ...
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35 Adverse Consequences of Overly-Rapid Correction of ...
https://www.karger.com/Article/Abstract/493243
Verbalis JG, Gullans SR: Hyponatremia causes large sustained reductions in brain content of multiple organic osmolytes in rats.
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36 Hyponatremia in the intensive care unit: How to avoid a ...
https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-015-0066-8
Hyponatremia is a common electrolyte derangement in the setting of the ... Taurine, one of the organic osmolyte excreted by glial cells as ...
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37 Manifestations of hyponatremia and hypernatremia in adults
https://www.medilib.ir/uptodate/show/2287
INTRODUCTION — Symptoms of hyponatremia or hypernatremia are primarily ... Substantial depletion of brain organic osmolytes occurs within 24 ...
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38 Azotemia protects the brain from osmotic demyelination on ...
https://sjkdt.org/article.asp?issn=1319-2442;year=2014;volume=25;issue=3;spage=558;epage=566;aulast=Dhrolia;type=3
However, after 24 h of rapid correction of hyponatremia in animals without azotemia, the brains remained depleted of organic osmolytes with little increase in ...
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39 Control of Brain Volume During Hyperosmolar and ...
https://www.annualreviews.org/doi/pdf/10.1146/annurev.me.44.020193.001445
KEY WORDS: hypernatremia, hyponatremia, osmolytes, amino acids, taurine, ... the role of organic osmolytes in brain volume regulation. Most experi.
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40 EDITORIAL Perioperative Control of Serum Sodium for Liver ...
https://openanesthesiajournal.com/VOLUME/4/PAGE/20/PDF/
Keywords: Liver transplantation, hyponatremia, central pontine myelinolysis, furosemide, ... of the organic osmolytes, which may predispose the brain to.
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41 NEJM-hyponatremia.pdf - Inside the Silver Fridge
https://gene-novikov-j8fn.squarespace.com/s/NEJM-hyponatremia.pdf
chronic hyponatremia owing to a direct effect of sodium and possibly vasopressin on these ... Organic osmolytes are small intracellular mol-.
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42 Formulas for fixing serum sodium: curb your enthusiasm
https://www.jvsmedicscorner.com/ICU-Renal_and_Metabolic_files/Formulas%20for%20fixing%20serum%20sodium.pdf
Key words: hyponatremia, hypernatremia, hypertonic saline, organic osmolytes. Nephrologists love formulas. It is fun to mathematically ...
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43 Question 22 of 28 - AccessSurgery
https://accesssurgery.mhmedical.com/Sol/SolQuestion?solQuizId=3896&solQuestionId=21
The rate of rise of intracellular potassium and organic osmolytes in the brain during correction of the hyponatremia occurs much more slowly than the rate ...
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44 (PDF) 202 Effects of dilutional hyponatremia on brain organic ...
https://www.academia.edu/8336242/202_Effects_of_dilutional_hyponatremia_on_brain_organic_osmolytes_and_water_content_in_patients_with_cirrhosis
Effects of Dilutional Hyponatremia on Brain Organic Osmolytes and Water Content in Patients With Cirrhosis Tea Restuccia,1,4,5 Beatriz Gomez-Ans ´ ´ 2,4 ...
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45 Chronic hyponatremia impairs memory in rats
https://joe.bioscientifica.com/view/journals/joe/206/1/105.xml
Verbalis JG & Gullans SR 1991 Hyponatremia causes large sustained reductions in brain content of multiple organic osmolytes in rats. Brain Research 567 274–282.
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46 Clinical review: Practical approach to hyponatraemia and ...
https://ccforum.biomedcentral.com/articles/10.1186/cc11805
Adaption to sustained hyponatraemia by loss of organic osmolytes has also been ... U-Na+ can be low in SIADH with a low salt intake.
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47 The Treatment of Hyponatremia.pdf - Saint Luke's Health System
https://www.saintlukeskc.org/sites/default/files/2018-08/The%20Treatment%20of%20Hyponatremia.pdf
Keywords: Hyponatremia, hypertonic saline, osmotic demyelination syndrome, myelinol- ysis, cerebral edema ... organic osmolytes after correction of hypona-.
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48 Evaluation of hyponatremia - Differential diagnosis of symptoms
https://bestpractice.bmj.com/topics/en-us/57
Hyponatremia is a common finding in clinical practice and is estimated to ... and synthesizing organic osmolytes to preserve cell volume.
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49 Hyponatremia - Pathophysiology, Causes, Diagnostic ...
https://www.youtube.com/watch?v=G3dHT-srtR4
Last Second Medicine
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50 Hyponatremia: Evaluation and Treatment
https://books.google.com/books?id=Sd69BAAAQBAJ&pg=PA90&lpg=PA90&dq=organic+osmolytes+hyponatremia&source=bl&ots=Gvy_-WMVTZ&sig=ACfU3U0_4RcemoEBW8BDA8-Q6UnSy49QEg&hl=en&sa=X&ved=2ahUKEwj0_OSF58H7AhWFGFkFHZNkDDsQ6AF6BQjWARAD
In vivo, the depletion of organic osmolytes during chronic hyponatremia has been shown to start as early as 4 h [34] after the induction of hyponatremia and ...
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51 Hyponatremia - YouTube
https://www.youtube.com/watch?v=1qIwk1UqTGY
Strong Medicine
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52 Osmolyte - Wikipedia
https://en.wikipedia.org/wiki/Osmolyte
Osmolytes are low-molecular weight organic compounds that influence the properties of biological fluids. ... Their primary role is to maintain the integrity of ...
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53 Case 6: Hyponatremia - Tech, health, art and coffee
https://doctorbara.wordpress.com/2017/11/06/case-6-hyponatremia/
Routine electrolyte panel shows a serum sodium level of 125 mmol/L and ... concentration of organic osmolytes to cope with hypotonicity.
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54 Brenner and Rector's The Kidney E-Book
https://books.google.com/books?id=NX7OCgAAQBAJ&pg=PA502&lpg=PA502&dq=organic+osmolytes+hyponatremia&source=bl&ots=ywHcFhbX1_&sig=ACfU3U32SYcZZulGCnRL3bZN18JWz5q2Ww&hl=en&sa=X&ved=2ahUKEwj0_OSF58H7AhWFGFkFHZNkDDsQ6AF6BQjJARAD
Electrolytes and organic osmolytes are lost quickly after the induction of hyponatremia, beginning on day (d) 0. Brain content of both solutes remains ...
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55 N-Acetylaspartate: A Unique Neuronal Molecule in the Central ...
https://books.google.com/books?id=tR44q6WWRBgC&pg=PA116&lpg=PA116&dq=organic+osmolytes+hyponatremia&source=bl&ots=q6KuJ0o4Z3&sig=ACfU3U1hpbgysCIDad68PNPucqmFbUxKdg&hl=en&sa=X&ved=2ahUKEwj0_OSF58H7AhWFGFkFHZNkDDsQ6AF6BQjXARAD
Subsequent studies confirmed that brain content of most organic osmolytes also decreases markedly during induced hyponatremia in mice (12) and rats (13,14).
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56 Organic osmolytes in acute hyponatremia | Sterns, R. H.; Baer, J ...
https://ur.booksc.eu/book/72737581/7ce643
Organic osmolytes in acute hyponatremia | Sterns, R. H.; Baer, J.; Ebersol, S.; Thomas, D.; Lohr, J. W.; Kamm, D. E. | download | BookSC.
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57 Hyponatremia - Knowledge @ AMBOSS
https://www.amboss.com/us/knowledge/Hyponatremia/
Hyponatremia is a state of low sodium levels (< 135 mEq/L). Sodium is the most important osmotically active particle in the extracellular ...
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58 Blockchain technology is revolutionising marketing
https://theblockchainland.com/2018/07/25/blockchain-technology-to-decentralise-marketing/
... Space Station for NASA does lasix cause hyponatremia ... Cl, and organic osmolytes accompanied by osmotically obligate water loss 20, 28.
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59 Hepatic Encephalopathy Cleveland Clinic Muscle improve 400
https://royalbahis1.com/20489-hepatic-encephalopathy-cleveland-clinic/
As glutamine acts as osmolyte, water moves inside the astrocyte causing low-grade cerebral ... inflammatory cytokines, hyponatremia or benzodiazepines.
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