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1 Vascular Nox (NADPH Oxidase) Compartmentalization ...
https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.10824
Vascular Nox (NADPH oxidase)-derived reactive oxygen species and endoplasmic reticulum (ER) stress have been implicated in hypertension.
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2 NADPH Oxidase activity is required for ER stress ... - OSTI.GOV
https://www.osti.gov/servlets/purl/1671332
Abstract. In all eukaryotes, the unfolded protein response (UPR) relieves endoplasmic reticulum (ER) stress, which is a potentially lethal condition caused ...
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3 The aftermath of the interplay between the endoplasmic ...
https://www.nature.com/articles/s12276-021-00560-8
Overall, we suggest that the ER stress response can induce ER or mitochondrial dysfunction, which may increase oxidative stress by dysregulating ...
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4 NADPH oxidase activity is required for ... - Wiley Online Library
https://onlinelibrary.wiley.com/doi/abs/10.1111/tpj.14091
Here we show that in Arabidopsis thaliana the respiratory burst oxidase homologs, RBOHD and RBOHF, contribute to the production of ROS during ER ...
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5 Crosstalk Between Oxidative Stress and ... - Frontiers
https://www.frontiersin.org/articles/10.3389/fphys.2019.00070/full
During ER stress response, there is accumulation of misfolded proteins within the ER where non-native disulfide bonds form resulting in the ...
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6 NADPH Oxidase-Dependent Production of Reactive Oxygen ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116410
The NADPH oxidase inhibitor, DPI, abolished both ROS production and UPR activation. These results show that ROS produced by NADPH oxidase ...
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7 Endoplasmic Reticulum Stress and Associated ROS - MDPI
https://www.mdpi.com/1422-0067/17/3/327/htm
Accumulating evidence suggests the interrelation of ER stress and ROS with redox signaling mediators such as protein disulfide isomerase (PDI)-endoplasmic ...
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8 NADPH oxidase activity is required for ER stress ... - Semantic Scholar
https://www.semanticscholar.org/paper/NADPH-oxidase-activity-is-required-for-ER-stress-in-Angelos-Brandizzi/8dec7b8246e245da5c32bb41e3b6e85a958b8765
In Arabidopsis thaliana the respiratory burst oxidase homologs, RBOHD and RBOHF, contribute to the production of ROS during ER stress, ...
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9 Endoplasmic reticulum stress triggers ROS signalling ...
https://academic.oup.com/jxb/article/65/5/1377/452605
Summary. Endoplasmic reticulum stress, which is induced by tunicamycin, triggers reactive oxygen species signalling via NADPH oxidase ...
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10 INHIBITION OF NADPH OXIDASE REDUCES ENDOPLASMIC ...
https://journals.lww.com/pancreasjournal/Fulltext/2005/11000/Inhibition_of_Nadph_Oxidase_Reduces_Endoplasmic.88.aspx
Background & Aims: Endoplasmic reticulum stress and its conserved rejoinder -the unfolded protein response (UPR)- have been found to play ...
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11 The correlation of IRE1α oxidation with Nox4 activation in ...
https://www.sciencedirect.com/science/article/pii/S2213231720309320
Oxidative stress attributable to the activation of a Nox4-containing NADPH oxidase is involved in aging-associated vascular dysfunction.
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12 Nox NADPH Oxidases and the Endoplasmic Reticulum - USP
https://observatorio.fm.usp.br/bitstream/OPI/7889/1/art_LAURINDO_Nox_NADPH_Oxidases_and_the_Endoplasmic_Reticulum_2014.PDF
Growing evidence suggests that Noxes are integral signaling elements of the unfolded protein response during ER stress, with Nox4 playing a dual prosurvival/ ...
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13 Role of endoplasmic reticulum stress in the protective effects ...
https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-017-1478-7
NADPH oxidase activity has been described as an intermediate for ER stress in vascular endothelial dysfunction [13]. In agreement with that, we ...
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14 Role of endoplasmic reticulum stress in 12/15-lipoxygenase ...
https://link.springer.com/article/10.1007/s00125-018-4560-z
Inhibition of ER stress reduced 15-HETE-induced-leucocyte adhesion, VEGFR2 phosphorylation and NADPH oxidase expression/activity. However, ...
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15 NADPH oxidase activity is required for ER stress survival in plants ...
https://journals.scholarsportal.info/details/09607412/v96i0006/1106_noairfessip.xml
Here we show that in Arabidopsis thaliana the respiratory burst oxidase homologs, RBOHD and RBOHF , contribute to the production of ROS during ER stress.
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16 NADPH oxidase links endoplasmic reticulum stress, oxidative ...
https://agris.fao.org/agris-search/search.do?recordID=US201301932872
NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis [2010]. Li, Gang; Scull, Christopher; Ozcan, ...
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17 The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH ...
https://www.jbc.org/article/S0021-9258(20)42957-6/fulltext
Within the family of NADPH oxidases, NOX4 is unique as it is predominantly localized in the endoplasmic reticulum, has constitutive activity ...
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18 12/15-lipoxygenase contributes to retinal inflammation ... - IOVS
https://iovs.arvojournals.org/article.aspx?articleid=2689993
However, inhibition of NADPH oxidase or deletion of NOX2 had no effect on ER stress induced by the 12/15-LO-derived metabolites both in vitro and in vivo.
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19 Working Together: Redox Signaling between the Endoplasmic ...
https://pubs.acs.org/doi/10.1021/acs.chemrestox.8b00379
Additional ER sources of ROS include members of the NADPH oxidase (NOX) ... UPR induction, although the UPR is expected to lessen ER stress.
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20 The Endoplasmic Reticulum Stress Sensor Inositol-Requiring ...
https://journals.asm.org/doi/10.1128/mBio.00705-15
ROS generation can be a potent antimicrobial mechanism, as patients with defects in the Nox2 NADPH oxidase are susceptible to recurrent and ...
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21 NADPH Oxidase activity is required for ER ... - ResearchGate
https://www.researchgate.net/publication/327680264_NADPH_Oxidase_activity_is_required_for_ER_stress_survival_in_plants
During ER stress, Ca 2+ is released from ER and activates RBOHs at the plasma membrane, leading to ROS production [164, 165]. In this context, it is possible ...
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22 Endoplasmic Reticulum Stress and Reactive Oxygen Species ...
https://mdpi-res.com/d_attachment/antioxidants/antioxidants-11-01240/article_deploy/antioxidants-11-01240.pdf?version=1656056261
Moreover, ER stress activates nicotinamide adenine dinucleotide phosphate (NADPH) oxidase- mediated ROS signaling, increases antioxidant ...
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23 Deficiency of Rac1 Blocks NADPH Oxidase Activation, Inhibits ...
https://diabetesjournals.org/diabetes/article-abstract/59/8/2033/14535
Rac1 via NADPH oxidase activation induces myocardial remodeling and dysfunction in diabetic mice. The role of Rac1 signaling may be associated with ER stress ...
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24 The Reactive Oxygen Species–Ethylene–Sugar Triad and the ...
https://www.cell.com/trends/plant-science/fulltext/S1360-1385(20)30384-8
Moreover, ER stress induces the expression and activity of NADPH oxidases encoded by respiratory burst oxidase homologues (RBOHs) [.
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25 Potential Roles of Endoplasmic Reticulum Stress and Cellular ...
https://www.hindawi.com/journals/omcl/2021/8830880/
Some cellular proteins affected by the physiopathology of diabesity include eNOS, ET-1, IRS-1, NADPH oxidase, and Cav-1. eNOS, as a cellular protein or enzyme, ...
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26 ATF4 regulates arsenic trioxide-mediated NADPH oxidase ...
https://scholarworks.iupui.edu/bitstream/handle/1805/16032/nihms-819474.pdf?sequence=1&isAllowed=y
Following ATO treatment, ATF4 activates NADPH oxidase by promoting assembly of the ... In addition, arsenic-mediated endoplasmic reticulum (ER) stress that ...
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27 Vascular Nox (NADPH oxidase) compartmentalization, protein ...
http://eprints.gla.ac.uk/161673/
Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension · Abstract.
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28 Role of NADPH oxidase in the regulation of autophagy in ...
https://portlandpress.com/clinsci/article/128/7/387/71160/Role-of-NADPH-oxidase-in-the-regulation-of
Nox4-derived H2O2 promotes autophagy in response to 7-KC through the inhibition of Atg4, thereby promoting survival through relief of ER stress ...
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29 Endoplasmic Reticulum Stress and Oxidative Stress
https://deepblue.lib.umich.edu/bitstream/handle/2027.42/63268/ars.2007.1782.lowlink.pdf_v03.pdf;sequence=1
apoptosis) and NOXA (neutrophil NADPH oxidase factor), are upregulated by p53 during ER stress. In addition, PumaJ/J cells and NoxaJ/J cells are resistant ...
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30 NADPH Oxidases, Reactive Oxygen Species, and the Kidney
https://jasn.asnjournals.org/content/24/10/1512
On the other hand, in pathologic conditions, a surplus of ROS in tissue results in oxidative stress with various injurious consequences such as inflammation and ...
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31 oxidative stress; and PKR activation to induce apoptosis
https://www.mattek.com/reference-library/nadph-oxidase-links-endoplasmic-reticulum-stress-oxidative-stress-and-pkr-activation-to-induce-apoptosis/
NADPH oxidase links endoplasmic reticulum stress; oxidative stress; and PKR activation to induce apoptosis ; Citation in paper containing MatTek reference " ...
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32 Critical role of X-box binding protein 1 in NADPH oxidase 4 ...
https://www.tandfonline.com/doi/full/10.1080/15384101.2016.1260210
NADPH oxidase 4 (NOX4) and the NOX4-related redox signaling are implicated in cardiac hypertrophy. NOX4 is interrelated with endoplasmic reticulum stress ...
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33 NADPH oxidase-mediated redox signaling promotes oxidative ...
https://elifesciences.org/articles/19493
Transient increases in mitochondrially-derived reactive oxygen species (ROS) activate an adaptive stress response to promote longevity.
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34 v10p11637.pdf - Theranostics
https://www.thno.org/v10p11637.pdf
Moreover, NADPH oxidases were ... endoplasmic reticulum (ER) stress and alters ... NADPH oxidases in Aβ-deposited RPE cells. The.
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35 Ochratoxin A induces ER stress and apoptosis in mesangial ...
https://www.sigmaaldrich.com/AR/en/tech-docs/paper/920105
NADPH oxidase inhibitor, apocynin, significantly attenuated OTA-induced cell apoptosis. Moreover, OTA markedly increased the calpain activity ...
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36 Endoplasmic reticulum stress and the development of ...
https://journals.physiology.org/doi/10.1152/ajpheart.00437.2016
Numerous risk factors for endothelial dysfunction can induce ER stress, ... UPR and oxidative stress by upregulating the oxidative enzyme NADPH oxidase 2 ...
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37 Nadph Oxidase 4 (NOX4) Controls Translational Homeostasis ...
https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A7227
D107. MITOCHONDRIA AND ER STRESS IN HOMEOSTASIS AND REPAIR · Nadph Oxidase 4 (NOX4) Controls Translational Homeostasis and Mitochondrial Biogenesis Via 4E-BP1.
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38 Mechanism of melanoma cells selective apoptosis induced by ...
https://www.oncotarget.com/article/12651/text/
Keywords: melanoma, NADPH oxidase, ROS, ER stress, NADPH analogue ... NS1 established an early Endoplasmic Reticulum stress by the early ...
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39 The Inhibition of NADPH Oxidase 1/Protein Disulfide ...
https://augusta.openrepository.com/handle/10675.2/624289
To maintain endoplasmic reticulum (ER) homeostasis, chaperones are overexpressed. Persistent ER stress activates the unfolded protein response (UPR), which can ...
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40 Oxidative and endoplasmic reticulum stress in β-cell ...
https://jme.bioscientifica.com/view/journals/jme/56/2/R33.xml
2015). ROS and RNS can be products of mitochondrial metabolism or can be produced in the cytoplasm, for example, by the enzymes NADPH oxidase and induced ...
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41 Activation of NADPH oxidase 4 in the endoplasmic reticulum ...
https://www.wikidata.org/wiki/Q37608713
Activation of NADPH oxidase 4 in the endoplasmic reticulum promotes cardiomyocyte autophagy and survival during energy stress through the protein kinase RNA- ...
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42 Yno1p/Aim14p, a NADPH-oxidase ortholog, controls ... - PNAS
https://www.pnas.org/doi/10.1073/pnas.1201629109
ROS Production by Yno1p Is Independent of the Mitochondrial Respiratory Chain and Does Not Contribute to ER Stress. ... We wanted to determine ...
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43 NADPH and glutathione redox link TCA cycle activity ... - bioRxiv
https://www.biorxiv.org/content/10.1101/822775v1.full
ER stress was also alleviated by impairing either TCA-dependent NADPH production or Glutathione Reductase. Conversely, stimulating TCA activity ...
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44 The superoxide dismutase mimetic tempol blunts diabetes ...
https://research.monash.edu/en/publications/the-superoxide-dismutase-mimetic-tempol-blunts-diabetes-induced-u
The superoxide dismutase mimetic tempol blunts diabetes-induced upregulation of NADPH oxidase and endoplasmic reticulum stress in a rat model of diabetic ...
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45 The Endoplasmic Reticulum Stress Response in ...
https://d-nb.info/1160575029/34
Upregulation of PDI and Activation of NADPH Oxidase. Isoforms. The development of ER stress and activation of the UPR may.
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46 NADPH oxidase: a therapeutic target for hyperoxaluria ...
https://www.future-science.com/doi/10.4155/fmc-2019-0275
NADPH oxidases act as a catalyst in the formation of superoxide anion radical and production of other reactive oxygen species (ROS) such as ...
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47 Targeted redox inhibition of protein phosphatase 1 by Nox4 ...
https://www.embopress.org/doi/10.15252/embj.201592394
This study shows that ROS-generating NADPH oxidase-4 inactivates PP1 at the ER via metal center oxidation, allowing for an enhanced stress signaling ...
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48 A common mechanism linking ER stress and oxidative stress ...
http://www.weizmann.ac.il/molgen/Rubinstein/research-activities/common-mechanism-linking-er-stress-and-oxidative-stress-dna-damage-and-cell
Endoplasmic reticulum (ER) stress and major chemotherapeutic agents damage DNA by ... LTC4 then elicits nuclear translocation of NADPH oxidase 4 (NOX4), ...
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49 Palmitic Acid Induces Endoplasmic Reticulum Stress In ...
https://dergipark.org.tr/en/pub/marumj/issue/33298/362169
Conclusion: PA induces ROS generation and the ER stress pathway that is mediated by IRE1 in liver cells. Addition of OA enhances these effects.
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50 Nox4 - multiple functions of a NADPH Oxidase in ... - YouTube
https://www.youtube.com/watch?v=s2VB33vgJWY
The Physiological Society
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51 Polyphenols in Mediterranean diet may modulate COVID-19 ...
https://www.news-medical.net/news/20221115/Polyphenols-in-Mediterranean-diet-may-modulate-COVID-19-inflammation.aspx
Oxidative stress exhausts antioxidant defenses and predisposes the individual ... production by a family of enzymes called NADPH oxidases.
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52 Catalase - Wikipedia
https://en.wikipedia.org/wiki/Catalase
Catalase is a common enzyme found in nearly all living organisms exposed to oxygen which catalyzes the decomposition of hydrogen peroxide to water and ...
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53 ER Stress Pathway - CUSABIO
https://www.cusabio.com/pathway/ER-Stress-pathway.html
Cells respond to endoplasmic reticulum stress by initiating a defense process called the unfolded protein response (UPR). UPR is composed of eukaryotic cellular ...
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54 PERK, IRE1: Method of Enhancing Immunotherapy Using ER ...
https://moffitt.org/research-science/academic-and-industry-partnerships/office-of-innovation/available-technologies/immunotherapies/20ma005-perk-ire1-method-of-enhancing-immunotherapy-using-er-stress-pathway-inhibitors/
Studies have demonstrated that two major ER stress response pathways, (inositol-requiring enzyme 1) IRE1α-XBP13,4 and (PKR-like endoplasmic-reticulum (ER) ...
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55 Endothelium and Cardiovascular Diseases: Vascular Biology ...
https://books.google.com/books?id=7wIxDwAAQBAJ&pg=PA505&lpg=PA505&dq=er+stress+nadph+oxidase&source=bl&ots=utNYfuEyUj&sig=ACfU3U0t_-fkxqAJ_gWnxNgPsIkQbutZgg&hl=en&sa=X&ved=2ahUKEwiM7fbHt8P7AhXjBjQIHVFmDlsQ6AF6BQjhARAD
Vascular NADPH oxidase activation represents the transduction of signals triggered ... ER stress is a frequent condition that results from ER inability to ...
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56 Insulin Resistance as a Risk Factor in Visceral and ...
https://books.google.com/books?id=haXXDwAAQBAJ&pg=PA313&lpg=PA313&dq=er+stress+nadph+oxidase&source=bl&ots=TYTKAn9ZbZ&sig=ACfU3U09QuoXNReRSeisDK8ovivQu1-K7A&hl=en&sa=X&ved=2ahUKEwiM7fbHt8P7AhXjBjQIHVFmDlsQ6AF6BQjdARAD
Induction of oxidative stress results in loss of cellular function. ... NADPH oxidase Arginine NO3 AGE High glucose Hyperglycemia ER stress ARA ER stress ...
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57 Handbook of Oxidative Stress in Cancer: Therapeutic Aspects
https://books.google.com/books?id=G9GPEAAAQBAJ&pg=PA1191&lpg=PA1191&dq=er+stress+nadph+oxidase&source=bl&ots=GFOY367iAH&sig=ACfU3U0gN5Tc06SflSgunELnprSC4eM0iw&hl=en&sa=X&ved=2ahUKEwiM7fbHt8P7AhXjBjQIHVFmDlsQ6AF6BQjeARAD
Major sources of endogenous ROS generation are mitochondrial respiratory chain and active NADPH oxidase, endoplasmic reticulum, peroxisomes were found as ...
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58 Reactive Oxygen Species (ROS), Nanoparticles, and ...
https://books.google.com/books?id=W9PVDwAAQBAJ&pg=PA269&lpg=PA269&dq=er+stress+nadph+oxidase&source=bl&ots=2aKtxrN6jH&sig=ACfU3U3OkiEXMCj_6GJ7DNhUfTPzxv6SsA&hl=en&sa=X&ved=2ahUKEwiM7fbHt8P7AhXjBjQIHVFmDlsQ6AF6BQjgARAD
... endoplasmic reticulum (ER) stress, cellular-metabolizing enzymes, ... of ROS from nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and ...
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