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1 Structure-activity relationship of furosemide-derived ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/9600663/
Structure-activity relationship of furosemide-derived compounds as antagonists of cerebellum-specific GABA(A) receptors. Eur J Pharmacol.
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2 Structure-activity relationship of furosemide-derived ...
https://eurekamag.com/research/009/470/009470363.php
Structure-activity relationship of furosemide-derived compounds as antagonists of cerebellum-specific GABA(A) receptors ... Lüddens, H.; Lang, H.J.; Korpi, E.R.
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3 Structure Activity Correlation for Diuretic Furosemide Congeners
https://www.karger.com/Article/Abstract/137799
The structure activity correlation of several groups of anthranilic acid derivatives was studied. 59 compounds, most of them possessing the ...
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4 Furosemide: Uses, Interactions, Mechanism of Action
https://go.drugbank.com/drugs/DB00695
Furosemide manages hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome. Furosemide ...
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5 Structure Activity Relationship of Diuretics - SlideShare
https://www.slideshare.net/SaifulIslam750/structure-activity-relationship-of-diuretics-232717175
Then, furosemide and other loop diuretics were obtained. The structure-activity relationship of thiazides using the electronic state and ...
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6 Structure–activity relationships of bumetanide derivatives ...
https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.13231
The potency of bumetanide exceeded that of the clinically established loop diuretics furosemide and ethacrynic acid in humans as well as dogs ( ...
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7 Diuretic compounds structurally related to furosemide
https://experts.umn.edu/en/publications/diuretic-compounds-structurally-related-to-furosemide
More specifically, issues regarding the chemistry, structure-activity relationships, and methods for evaluating the activity of loop ...
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8 SYNTHESIS OF FUROSEMIDE - YouTube
https://www.youtube.com/watch?v=2ItmmL2upss
GPAT DISCUSSION CENTER
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9 Sulfonamides: Historical Discovery Development (Structure ...
https://openaccesspub.org/iiij/article/749
In other words we tried to set Structure-Activity-Relationship (SAR) from these chemical structures for sulfonamide ... Furosemide, N\A, 2.03, 330.739, 1.5.
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10 Furosemide - AHA Journals
https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.34.5.910
Furosemide. A Clinical Evaluation of Its Diuretic Action ... Structural formulae of furosemide and related com- ... Dose-Response Relationships in Edematous.
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11 934_Chapter-4 Diuretics.pdf
https://www.mlsu.ac.in/econtents/934_Chapter-4%20Diuretics.pdf
Hydrochlorthiazide - Furosemide ... Structure Activity Relationship (SAR) ... methazolamide which also retain carbonic anhydrase inhibitor activity.
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12 Mechanism of action of diuretics - UpToDate
https://www.uptodate.com/contents/mechanism-of-action-of-diuretics
› contents › mechanism-of-acti...
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13 ACS Symposium Series (ACS Publications)
https://pubs.acs.org/doi/10.1021/bk-1978-0083.ch002
Structure-Activity Relationships of Aminobenzoic Acid Diuretics ... Thus, furosemide fit the structural requirements for diuretic activity ...
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14 Structure-activity relationship of furosemide-derived ... - Julkari
https://www.julkari.fi/handle/10024/85159
Structure-activity relationship of furosemide-derived compounds as antagonists of cerebellum-specific GABA(A) receptors · Luddens H; Lang HJ; Korpi ER (1998) ...
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15 QSAR analysis and molecular docking study of pyrrolo
http://journals.uran.ua/sr_pharm/article/view/234493
QSAR analysis showed that the diuretic activity is determined by the geometric and spatial structure of molecules, logP, the energy values, RDF- ...
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16 Furosemide analogues and compositions and uses thereof for ...
https://patents.google.com/patent/WO2020257940A1/en
The present application provides furosemide analogues of the general formula Z ... "Structure-activity relationship of furosemide-derived compounds as ...
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17 Pharmaceutical Chemistry of Antihypertensive Agents
https://books.google.com/books?id=LMl4Sd38q4kC&pg=PA72&lpg=PA72&dq=furosemide+structure+activity+relationship&source=bl&ots=7SQXOwQbWr&sig=ACfU3U2sBKQPTtdHrBfM6Ydz1Qb4rlCfow&hl=en&sa=X&ved=2ahUKEwjnxN3PtMT7AhWEVjUKHeOgB8EQ6AF6BQiAAhAD
157 B. HISTORY AND STRUCTURE - ACTIVITY RELATIONSHIP Furosemide belongs in the group of diuretics referred to as " high - ceiling " or " loop " diuretics as ...
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18 Practice Problems Med Chem Exam II (Winter Quarter, 1998)
http://webhome.auburn.edu/~rileytn/py421/exsam2.html
10. Based upon structure-activity relationships, comment on the relative calcium-channel blocking potencies of felodipine and amlodipine with that of nifedipine ...
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19 Small-molecule screen identifies inhibitors of the ... - PNAS
https://www.pnas.org/doi/pdf/10.1073/pnas.0812756106
of structure/activity relationships. We also used one of the com- ... salt reabsorption, loop diuretics (furosemide or LASIX and.
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20 Furosemide - Wikipedia
https://en.wikipedia.org/wiki/Furosemide
"Lasix" redirects here. For the method of eye surgery, see LASIK. Furosemide is a loop diuretic medication used to treat fluid build-up due to heart failure, ...
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21 Everything we always wanted to know about furosemide but ...
https://journals.physiology.org/doi/10.1152/ajprenal.00476.2015
Modulation of NKCC2 expression and activity in kidney and heart failure is ill-defined. Lastly, furosemide's effects on cutaneous sodium stores and on uric acid ...
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22 High ceiling or Loop diuretics | Synthesis and Drug Profile
https://www.pharmacy180.com/article/high-ceiling-or-loop-diuretics---nonmercurial-diuretics-2274/
Furosemide - Synthesis and Drug Profile. ... Mode of action: A glycoprotein with 12 membrane-spanning domains has found its ... SAR of Loop Diuretics ...
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23 Chemical structures of clinically approved loop diuretics ...
https://www.researchgate.net/figure/Chemical-structures-of-clinically-approved-loop-diuretics-According-to-their-structures_fig1_326066177
... the present study we used 8 loop diuretics of the 3 structurally different groups shown in Fig. 1 to eval- uate structure-activity relationship of ...
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24 Furosemide | C12H11ClN2O5S - ChemSpider
http://www.chemspider.com/Chemical-Structure.3322.html
Structure, properties, spectra, suppliers and links for: Furosemide, 54-31-9.
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25 Azosemide is more potent than bumetanide and various other ...
https://www.nature.com/articles/s41598-018-27995-w.pdf?origin=ppub
bumetanide and furosemide, none of the chemically diverse loop ... uate structure-activity relationship of inhibition of hNKCC1A vs.
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26 Clinical Pharmacology in Diuretic Use - CJASN
https://cjasn.asnjournals.org/content/14/8/1248
(B) Homology structural model of the loop diuretic–sensitive NKCC2 ... Although the t1/2 of furosemide is short, its duration of action is ...
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27 Furosemide (Frusemide) - IARC Publications
https://publications.iarc.fr/_publications/media/download/1780/d54035f0e4970c154e8fd4fd454388c273168bee.pdf
1.2 Structural and molecular formulae and molecular weight ... balance of the saluretic activity of furosemide.l Pharol. ex. Ther., 149,40-408.
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28 How Do Loop Diuretics Act? | SpringerLink
https://link.springer.com/article/10.2165/00003495-199100413-00003
Cl+ channel blockers in the thick ascending limb of the loop of Henle. Structure-activity relationship. Pflügers Archiv 407 (Suppl.
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29 KEGG PATHWAY: map07017
https://www.genome.jp/dbget-bin/www_bget?map07017
D07999, Sodium furosemide. D08001, Furosemide diolamine ... [Face of Medecine: Structure Activity Relationship] (In Japanese). Journal. Yakuji Nippo (1999).
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30 [Diuretics] | Health & Environmental Research Online (HERO)
https://hero.epa.gov/hero/index.cfm/reference/details/reference_id/4969931
Then, furosemide and other loop diuretics were obtained. The structure-activity relationship of thiazides using the electronic state and ...
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31 Simultaneous determination of five diuretic drugs using ...
https://bmcchem.biomedcentral.com/articles/10.1186/s13065-021-00764-z
Chemical structures of furosemide (a), torasemide (b), ... Lykke K, Töllner K, Erker T (2015) Structure-activity relationships of bumetanide ...
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32 Advanced Analytical Tools for the Estimation of Gut ... - MDPI
https://www.mdpi.com/2076-3417/12/3/1326/pdf-vor
Abstract: The present study aims at developing a quantitative structure–activity relationship. (QSAR) model for the determination of gut ...
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33 LASIX (furosemide) Tablets 20, 40, and 80 mg WARNING ...
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/016273s068lbl.pdf
The structural formula is as follows: CLINICAL PHARMACOLOGY. Investigations into the mode of action of LASIX have utilized micropuncture studies in rats, ...
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34 diuretics.pdf - Vidyabharti College Of Pharmacy
https://vbcop.org/pdf/bpharmsm/diuretics.pdf
Structure Activity Relationship Of Drugs. • Synthesis. • Uses. • Adverse Effects. • References ... example, furosemide and bumetanide respectively.
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35 Furosemide Injection Formulation - Merck
https://www.merck.com/docs/product/safety-data-sheets/ah-sds/Furosemide%20Injection%20Formulation_AH_IE_6N.pdf
stance; PICCS - Philippines Inventory of Chemicals and Chemical Substances; (Q)SAR - (Quanti- tative) Structure Activity Relationship; ...
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36 Acetazolamide | Deranged Physiology
https://derangedphysiology.com/main/cicm-primary-exam/required-reading/renal-system/Chapter%20023/acetazolamide
Furosemide is also a sulfonamide, by that definition. No other classification structures are available, and "sulfonamide" is probably good ...
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37 Loop Diuretics | Concise Medical Knowledge - Lecturio
https://www.lecturio.com/concepts/loop-diuretics/
Chemical structure of furosemide ... Can be absorbed orally (slightly slower onset of action) or intravenously (faster) ...
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38 Furosemide Injection Formulation - MSD
https://www.msd.com/docs/product/safety-data-sheets/ah-sds/Furosemide%20Injection%20Formulation_AH_CA_EN.pdf
Furosemide Injection Formulation. Version ... es; (Q)SAR - (Quantitative) Structure Activity Relationship; REACH - Regulation (EC) No.
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39 Charles Schonberger | Colorado PROFILES - CU Denver
https://profiles.ucdenver.edu/display/12051563
Shani J, Schoenberg S, Lien EJ, Cherkez S, Feifel M, Schonberger C, Yellin H. Structure activity correlation for diuretic furosemide congeners.
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40 INDACRINONE - Inxight Drugs
https://drugs.ncats.io/substance/B926Y9U4QN
Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. 2005 Jun 2. 15916432. Showing 1 to 1 of 1 entries.
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41 Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug ...
https://digital.csic.es/bitstream/10261/259920/1/crystals_11_2021_Duane.pdf
impact on the intimate 3D structure of the solid and therefore on its ... being associated with the suppression of plasma renin activity or ...
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42 Quantitative Structure-Activity Relationships (QSARs ...
http://ajptr.com/assets/upload/publish_article/AJPTR-83013_2207.pdf
Quantitative Structure-Activity Relationships (QSARs) Modeling of. Anti-hypertensive Activity of Dichloroanilino Imidazoline ... High ceiling: Furosemide.
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43 Diuretics
https://www.minia.edu.eg/pharm/files/Lect%202,%20Med.Chem%20II.%20%D8%A7%D9%84%D9%81%D8%B5%D9%84%20%D8%A7%D9%84%D8%AB%D8%A7%D9%85%D9%86.pdf
SAR of 5-Sulfamoyl 2- and –3- aminobenzoic acid derivatives: ... N.B: Furosemide and bumetanide are similar to the carbonic anhydrase inhibitors, thiazides ...
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44 maulana abul kalam azad university of ... - B.PHARM Syllabus
http://makautexam.net/aicte_details/Syllabus/BPHARM/sem520.pdf
3. know the Structural Activity Relationship (SAR) of different class of drugs ... Loop diuretics: Furosemide*, Bumetanide, Ethacrynic acid. Potassium.
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45 Small-molecule screen identifies inhibitors of the neuronal K ...
https://www.vumc.org/delpire-lab/publication/small-molecule-screen-identifies-inhibitors-neuronal-k-cl-cotransporter-kcc2
To identify molecules that affect KCC2 activity, we developed a ... effect on KCC2 function, and provide an analysis of structure/activity relationships.
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46 Furosemide Tablets for Dogs - Drugs.com
https://www.drugs.com/vet/furosemide-tablets.html
› vet › furosemide-tablets
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47 Furosemide as an Environmental-Friendly Inhibitor of ...
http://www.electrochemsci.org/papers/vol10/100201708.pdf
Keywords: corrosion, Furosemide, Inhibition efficiency, PM3, Zinc ... about qualitative structure-activity relationship (QSAR) of certain ...
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48 Exploring Structure-Activity Relationship in Tacrine ...
https://pdfs.semanticscholar.org/5f3c/6123792edaa4ccef23867911f6a1c81c7b86.pdf
Exploring Structure-Activity Relationship in ... (THA, donepezil, ibuprofen) and negative (furosemide, chlorothiazide, ranitidine) controls ...
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49 Diuretic Therapy in Heart Failure – Current Approaches
https://www.ecrjournal.com/articles/diuretic-therapy-heart-failure-current-approaches
... secondary to an abnormality of the cardiac structure or function. ... Loop diuretics include furosemide, bumetanide, torsemide and ...
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50 CFNP TAP Review Furosemide 9/4/2003
https://www.ams.usda.gov/sites/default/files/media/Furosemide%20TR.pdf
exact mode of action of furosemide has not been clearly defined; in contrast to ethacrynic acid, ... The structural formula is as follows:.
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51 Diuretics | Frusemide | Bombax Ceiba | Urine
https://www.ijpsonline.com/articles/diuretic-effects-of-young-fruit-extracts-of-bombax-ceiba-l-in-rats.html?view=mobile
Although, the onset of this diuretic action was gradual (within 5 h), ... to elucidate the probable structure activity relationship of biomolecules.
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52 Foye's Principles of Medicinal Chemistry
https://books.google.com/books?id=qLJ6Bs1Qml4C&pg=PA526&lpg=PA526&dq=furosemide+structure+activity+relationship&source=bl&ots=p00-KucSlG&sig=ACfU3U2V0_jjzknVsDTeAqM6kXWXAsIJyw&hl=en&sa=X&ved=2ahUKEwjnxN3PtMT7AhWEVjUKHeOgB8EQ6AF6BQiFAhAD
A diuretic structurally related to furosemide is bumetanide. Structure-activity Relationships. For bumetanide, a phe- noxy group has replaced the customary ...
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53 Mechanisms and management of diuretic resistance in ...
https://pmj.bmj.com/content/79/931/268
Relationship between renal furosemide excretion rate or urinary diuretic concentration (log value) and excretion of sodium in normal subjects (left curve) ...
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54 Diuretics - CV Pharmacology
https://www.cvpharmacology.com/diuretic/diuretics
Specific Drugs ; Thiazide, chlorothiazide, primarily used for treating edema ; chlorthalidone, thiazide-like in action, not structure; long half-life; more ...
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55 ORIGINAL RESEARCH article - Frontiers
https://www.frontiersin.org/articles/10.3389/fvets.2020.00151/full
Torasemide and furosemide both inhibit the activity of the Na+-K+-2Cl− symporter in the thick ascending limb of the loop of Henle by ...
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56 CHEBI:3640 - chlorothiazide - EMBL-EBI
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=3640
Working in a separate mechanism from furosemide and absorbed enterically as a reconstituted suspension administered through a nasogastric tube ( ...
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57 Small-Molecule Screen Identifies Inhibitors of the ... - jstor
https://www.jstor.org/stable/40455204
of structure/activity relationships. ... Furosemide and bumetanide also inhibit K-CI cotrans- ... Note the significant furosemide-sensitive Tl+ uptake.
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58 furosemide: Topics by Science.gov
https://www.science.gov/topicpages/f/furosemide
Furthermore, this diuretic may adversely influence renal function when ... Structure-activity relationships of a pharmacophore based on furosemide included ...
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59 February 2009
https://www.tnmgrmu.ac.in/images/nqb/564237KX.pdf
d) Outline the synthesis of Acetazolamide and furosemide. (5) ... b) Explain the mechanism and structure activity relationship of the.
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60 Fundamentals of pharmacology - Knowledge @ AMBOSS
https://www.amboss.com/us/knowledge/Fundamentals_of_pharmacology/
Modeling of the structure-activity relationship can help predict the biological action of a substance and, accordingly, plays a major role in ...
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61 Diuretics - Physiopedia
https://www.physio-pedia.com/Diuretics
... to the differences in the sites of action of diuretics on the kidney structure. The different types include: Loop diuretics (eg, furosemide, bumetanide, ...
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62 Functional block copolymer micelles based on poly (jasmine ...
https://pubs.rsc.org/en/content/articlehtml/2022/ra/d2ra03962a
bStructural Bioinformatics Laboratory, Faculty of Science and ... Hydrophobic drugs used in the studies were furosemide (pKa 3.8, ...
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63 Synthesis and in vivo diuretic activity of some new ...
https://www.tandfonline.com/doi/pdf/10.3109/14756366.2015.1128425
(V), indapamide (VI), furosemide (VII) and bumetanide (VIII) ... The structure activity relationship study illustrated that the.
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64 SITE 1 DIURETICS (Work in Proximal Tubule) Carbonic ...
http://www.philadelphia.edu.jo/academics/bjaidi/uploads/Diuretics_Medicinal_Chemistry-III.pptx
Metadisulfamoylbenzene derivatives SAR. Maximal diuretic activity is observed ... For example, furosemide and bumetanide respectively.
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65 Pediatric Pharmacotherapy - The University of Virginia
https://med.virginia.edu/pediatrics/wp-content/uploads/sites/237/2015/12/199510.pdf
action, monitoring parameters, and indications for use of ... relationship between furosemide-induced bilirubin displacement and the.
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66 3RF4: Ancylostoma ceylanicum mif in complex with furosemide
https://www.rcsb.org/structure/3RF4
Total Structure Weight: 40.48 kDa; Atom Count: 3,095; Modelled Residue Count: 348; Deposited Residue Count: 348; Unique protein chains: 1.
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67 furosemide | Ligand page
https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4839
GtoPdb Ligand ID: 4839 ... Comment: Furosemide is a loop diuretic drug. Click here for help. Ligand Activity Visualisation Charts. These are box plot that provide ...
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68 Benefits and risks of furosemide in acute kidney injury
https://ether.stanford.edu/urology/Furosemide.pdf
The site of action of furosemide is Na-K-Cl2 co-transporter at the intra-luminal side of the ascending ... inverse relationship to the severity of AKI [31].
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69 High Blood Pressure Symptoms and Causes | cdc.gov
https://www.cdc.gov/bloodpressure/about.htm
Your blood pressure changes throughout the day based on your activities. Having blood pressure measures consistently above normal may result in a diagnosis ...
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70 Medicinal Chemistry-II | B Pharmacy Notes - Carewell Pharma
https://www.carewellpharma.in/B_Pharmacy/Notes/5th_Sem/Medicinal_Chemistry-II/
Loop diuretics: Furosemide*, Bumetanide, Ethacrynic acid. Potassium sparing Diuretics: Spironolactone, ... Local Anesthetics: SAR of Local anesthetics.
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71 Furosemide (Molecule of the Month for April 2003)
https://www.3dchem.com/Furosemide.asp
Furosemide is a sulfonamide, its chemical name is 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid and its molecular formula is C12H11ClN2O5S.
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72 Genetic diversity of variants involved in drug response and...
https://journals.lww.com/jpharmacogenetics/Fulltext/2016/01000/Genetic_diversity_of_variants_involved_in_drug.4.aspx
This was carried out on the four sets of populations described above to dissect their relationships at the ADME SNPs. STRUCTURE analysis. We carried out ...
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73 Furosemide: Generic, Uses, Side Effects, Dosages ... - RxList
https://www.rxlist.com/consumer_furosemide_lasix/drugs-condition.htm
Furosemide is known as a diuretic (like a "water pill"). It helps your body get rid of extra water by increasing the amount of urine you make.
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74 Furosemide
https://www.drugfuture.com/chemdata/Furosemide.html
Molecular and crystal structure: J. Lamotte et al., Acta Crystallogr. B34, 1657 (1978). Review of pharmacokinetics: L. Z. Benet, J. Pharmacokinet. Biopharm. 7, ...
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