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1 RNF43 G659fs is an oncogenic colorectal cancer mutation ...
https://www.nature.com/articles/s41467-022-30794-7
Our study demonstrates that RNF43 is a frequently mutated gene in colorectal and endometrial cancers, enriched in the setting of MSI. These ...
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2 RNF43 - My Cancer Genome
https://www.mycancergenome.org/content/gene/rnf43/
RNF43 is altered in 3.17% of all cancers with colon adenocarcinoma, breast invasive ductal carcinoma, pancreatic adenocarcinoma, endometrial endometrioid ...
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3 RNF43 truncations trap CK1 to drive niche‐independent self ...
https://www.embopress.org/doi/10.15252/embj.2019103932
RNF43 mutations, found in ~19% of colorectal cancer cases, are mutually exclusive to APC mutations and considered a prime hallmark of Wnt- ...
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4 The Functional Landscape of Patient-Derived RNF43 ...
https://aacrjournals.org/cancerres/article/80/24/5619/645938/The-Functional-Landscape-of-Patient-Derived-RNF43
These mutations occur along the entire RNF43 coding sequence in multiple cancer types, including colorectal, pancreatic, ovarian, ...
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5 RNF43 pathogenic Germline variant in a family with colorectal ...
https://onlinelibrary.wiley.com/doi/10.1111/cge.14064
The role of RNF43 as a cause of an inherited predisposition to colorectal cancer (CRC) is yet to be fully explored. This report presents our ...
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6 RSPOfp/RNF43 Mutations: Therapeutic Options in Colorectal ...
https://www.physiciansweekly.com/rspofp-rnf43-mutations-therapeutic-options-in-colorectal-cancer/
There were 7,245 colorectal cancer samples in the discovery cohort. RSPOfp and RNF43 mutations were found in 1.3% (n=94) and 6.1% (n=443) of ...
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7 Patient characteristics and survival outcomes in ...
https://ascopubs.org/doi/abs/10.1200/JCO.2021.39.3_suppl.473
... gastrointestinal cancers harboring RSPO3 gene fusions or RNF43 ... 6 of whom had colorectal cancer (CRC) and had PTPRK as the fusion ...
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8 RNF43 and ZNRF3 are commonly altered in ... - Oncotarget
https://www.oncotarget.com/article/12130/text/
The RNF43 and ZNRF3 mutant colorectal cancer cell lines were all MSI, and all harbour a mutation within the EGFR-MAPK signalling pathway.
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9 GR-RNF43 Regulation in Colorectal Cancer - Open Access Pub
https://openaccesspub.org/jpgr/article/265
In HCT116 colorectal cancer cell line, knock-down of GR levels with siRNA resulted in increased RNF43 levels, suggesting that GR might be a negative regulator ...
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10 RNF43 gene - Myriad Genetics
https://services.myriad.com/clinical-summaries/gene-pdf.php?gene=RNF43&allele=1
GENETIC CANCER RISK. Colorectal. Elevated Risk. RNF43 gene Overview. Serrated Polyposis Syndrome (SPS). 1, 2, 3, 4, 5, 6. Mutations in RNF43 ...
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11 RNF43 Mutations Warrant Further Validation for Potential
https://www.esmo.org/oncology-news/rnf43-mutations-warrant-further-validation-for-potential-to-prioritise-anti-egfr-braf-combinations-in-selected-patients-with-brafv600e-mutated-mcrc
Findings from an assessment of predictive value of RNF43 status in patients with BRAFV600E-mutated metastatic colorectal cancer.
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12 RNF43 Is Frequently Mutated in Colorectal ... - Harvard DASH
https://dash.harvard.edu/bitstream/handle/1/37365198/HODIS-DOCTOROFMEDICINETHESIS-2020.pdf?sequence=1&isAllowed=y
Unexpectedly, our whole-exome sequencing of colorectal cancers identified a large number of non-silent somatic mutations in RNF43. DNA isolated from a discovery.
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13 Late Breaking Advances RNF43 Mutations in Colon Cancer ...
https://www.youtube.com/watch?v=Ej_aN3nmr0s
The Society for Translational Oncology
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14 Inactivating mutations of RNF43 confer Wnt dependency in ...
https://www.pnas.org/content/110/31/12649
Here, we show that RNF43 inhibits Wnt/β-catenin signaling by reducing the membrane ... Truncation mutations of APC are found in 80% of colorectal cancer.
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15 Researchers Discover Predictive Biomarker of Response to ...
https://ascopost.com/news/october-2022/researchers-discover-predictive-biomarker-of-response-to-therapy-in-patients-with-microsatellite-stable-metastatic-colorectal-cancer/
Researchers have unmasked mutations in the RNF43 gene as ... Mutations in BRAF V600E occur in around 10% of metastatic colorectal cancers, ...
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16 RNF43 Gene - Ring Finger Protein 43 - GeneCards
https://www.genecards.org/cgi-bin/carddisp.pl?gene=RNF43
Diseases associated with RNF43 include Sessile Serrated Polyposis Cancer Syndrome and Colorectal Cancer. Among its related pathways are ...
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17 Rnf43 Mutation As A Biomarker For Immune Checkpoint ...
https://www.researchsquare.com/article/rs-536739/v1.pdf
Methods: We analysed data from a colon cancer immunotherapy cohort (n = 110, ICI cohort), including mutation data and clinical data, to identify ...
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18 RNF43 is overexpressed in colon tumors and correlates with ...
https://www.researchgate.net/figure/RNF43-is-overexpressed-in-colon-tumors-and-correlates-with-poor-prognosis-A-In-situ_fig1_281624303
Given its fundamental role in development and cancer, the Wnt-beta-catenin signaling pathway is tightly controlled at multiple levels. RING finger protein 43 ( ...
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19 REVIEWS - Regulation of Wnt receptor activity: Implications for ...
https://www.jbc.org/article/S0021-9258(21)00575-5/pdf
Colorectal cancer (CRC) is the second most common cause of cancer-related death and the ... RNF43 itself is also a strong Wnt target gene.
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20 The functional landscape of patient derived RNF43 mutations ...
https://www.biorxiv.org/content/10.1101/2020.03.25.006999v1.full.pdf
RNF43 mutations that predict Wnt inhibitor sensitivity. Page 1 of 34 ... Keywords: Biomarker, Pancreatic Cancer, colorectal cancer, G659fs, ...
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21 Regulation of Wnt receptor activity: Implications for therapeutic ...
https://www.sciencedirect.com/science/article/pii/S0021925821005755
RNF43. ring finger protein 43. ZNRF3. zing and ring finger 3. Colorectal cancer (CRC) is the second most common cause of cancer-related death and the third ...
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22 RNF43 inhibits WNT5A-driven signaling and suppresses ...
https://elifesciences.org/articles/65759
RNF43 interacts with receptor complexes of the Wnt/PCP signaling and its ... Further, in colorectal cancer, RNF43 mutations were found to ...
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23 Investigating RNF43 Mutations as Biomarkers for ctDNA ...
https://ourarchive.otago.ac.nz/handle/10523/10560
Abstract: This project aimed to investigate the utility of RNF43 mutations for circulating tumour DNA (ctDNA) surveillance of colorectal cancer (CRC). CRC is ...
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24 RNF43 - Inherited Cancer Registry (ICARE)
https://inheritedcancer.net/tag/rnf43/
New colon cancer and polyposis genes recently identified include NTHL1, POLE, POLD1, MSH3, and RNF43. Previous studies suggest these genes raise the risk ...
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25 RNF43 is frequently mutated in colorectal and - ProQuest
https://www.proquest.com/scholarly-journals/rnf43-is-frequently-mutated-colorectal/docview/1634756468/se-2
RNF43 is frequently mutated in colorectal and endometrial cancers ... RNF43 encodes an E3 ubiquitin ligase that negatively regulates Wnt signaling.
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26 Ubiquitin ligase RNF43 in Wnt signaling - Science
https://www.science.org/doi/10.1126/scisignal.aad2744
What evidence is there that RNF43 is involved in colon cancer, and how is it thought to regulate Wnt signaling? Interviewee – Markus Gerhard.
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27 The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal ...
http://genesdev.cshlp.org/content/28/4/305
Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently identified as an exquisite ...
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28 Entry - *612482 - RING FINGER PROTEIN 43; RNF43 - OMIM
https://www.omim.org/entry/612482
▽ Description. RNF43 is a HAP95 (AKAP8L; 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer (Yagyu ...
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29 Identification of Two Wnt-Responsive Elements in the Intron of ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086582
RING finger protein 43 (RNF43), an E3-type ubiquitin ligase, is frequently up-regulated in human colorectal cancer.
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30 Molecular basis underlying colorectal cancer revealed
https://www.eurekalert.org/news-releases/697528
image: Oncogenic RNF43 which induces aberrant activation of Wnt signaling and suppression of an important tumor suppressor gene p53 at the ...
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31 A Study to Assess Efficacy of RXC004 +/- Nivolumab in Ring ...
https://clinicaltrials.gov/ct2/show/NCT04907539
Colorectal Cancer, Drug: RXC004 Biological: Nivolumab Biological: Denosumab ... in Patients With Ring Finger Protein 43 (RNF43) or R-spondin ...
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32 Commonly observed RNF43 mutations retain ... - Gale
https://go.gale.com/ps/i.do?id=GALE%7CA621714253&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=09509232&p=AONE&sw=w
Our data also suggest that only colorectal cancer cells harboring N-terminal mutations of RNF43 convey Wnt-dependency onto the tumor cells.
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33 Unsuspected gene found frequently mutated in ... - ScienceDaily
https://www.sciencedaily.com/releases/2014/10/141026195334.htm
They suggest that the RNF43 mutation may serve as a biomarker that identifies patients with colorectal and endometrial cancer who could ...
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34 Annals of Oncology
https://www.annalsofoncology.org/article/S0923-7534(22)01139-5/pdf
Association of MSS/MSI-RNF43 molecular subtypes and clinical outcome of metastatic BRAF-V600E colorectal cancer patients treated with anti-BRAF/EGFR ± ...
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35 RNF43 G659fs is an oncogenic colorectal ... - Broad Institute
https://www.broadinstitute.org/publications/broad1160166
RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition. Publication Type, Journal ...
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36 RNF43 Inhibits Cancer Cell Proliferation and Could be a ...
https://www.karger.com/Article/Fulltext/430154
Previous studies have identified RNF43 as a novel oncoprotein in colorectal cancer [17,18,19]. The current study demonstrated that RNF43 ...
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37 RNF43 is frequently mutated in colorectal and endometrial ...
https://baam.library.gwu.edu/discovery/fulldisplay?docid=cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4283570&context=PC&vid=01WRLC_GWA:live&lang=en&search_scope=DN_and_CI&adaptor=Primo%20Central&tab=Everything&query=creator%2Cexact%2C%20Lawrence%2C%20Michael%20%2CAND&facet=creator%2Cexact%2C%20Lawrence%2C%20Michael%20&mode=advanced&offset=30
We report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that ...
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38 e001437.full.pdf - The Journal for ImmunoTherapy of Cancer
https://jitc.bmj.com/content/jitc/8/2/e001437.full.pdf
ARID1A, RNF43, and KM2B mutations in MSI colon cancer. A robust microsatellite status–related ... dMMR- MSI colon tumors are characterized.
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39 Frequent RNF43 mutation contributes to ... - Springer Link
https://link.springer.com/article/10.1007/s13238-020-00691-0
Signet-ring cell carcinoma (SRCC) is a rare subtype of colorectal cancer (CRC) characterized histologically by the accumulation of mucins in ...
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40 RNF43 frameshift mutations contribute to tumourigenesis in ...
https://europepmc.org/article/med/31122752
... mutations contribute to tumourigenesis in right-sided colon cancer. ... RNF43 frameshift mutations R117.fs and G659.fs and BRAF V600E mutation were ...
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41 RNF43 - Curated Genes - ClinGen
https://search.clinicalgenome.org/kb/genes/HGNC:18505
RNF43. View Gene Facts ... RNF43. sessile serrated polyposis cancer syndrome. MONDO:0014919. AD, Colon Cancer GCEP · Limited · 10/23/2017.
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42 LETTER - Tumour suppressor RNF43 is a stem-cell E3 ligase ...
https://www.hubrecht.eu/app/uploads/2017/11/nature11308.pdf
colorectal cancer cell line HCT116, reconstitution of RNF43 expression removes its response to exogenous Wnt. We conclude that RNF43 and ZNRF3 reduce Wnt ...
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43 Characterization of RNF43, a novel negative regulator of the ...
https://push-zb.helmholtz-muenchen.de/deliver.php?id=3250
Transcriptional repression of RNF43 by CpG methylation in colon cancer cell lines 169! 3.5.2! High RNF43 mRNA expression is correlated with poor prognosis ...
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44 Loss of RNF43 Function Contributes to Gastric ... - mediaTUM
https://mediatum.ub.tum.de/doc/1659070/1659070.pdf
RNF43 mutations found in gastric tumors conferred resistance to DNA damage. ... survival of colorectal cancer patients.29. To determine.
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45 Genetic and epigenetic alterations of colorectal cancer
http://irjournal.org/journal/view.php?number=300
A subsequent study has found that RNF43 mutation is accompanied by BRAF mutations in serrated pathway. MSI-H CRC tends to occur in females, the ...
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46 Gene Mutated in Colorectal and Endometrial Cancers ...
https://www.genengnews.com/topics/translational-medicine/gene-mutated-in-colorectal-and-endometrial-cancers-surprises-scientists/
In animal models of cancer, tumors that harbor RNF43 mutations have been found to be sensitive to new Wnt pathway inhibitors that are now in ...
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47 RNF43 and ZNRF3 are commonly altered ... - Semantic Scholar
https://pdfs.semanticscholar.org/3e4e/5680414c442fc766c934c9d58eebf674c079.pdf
Keywords: RNF43, colorectal cancer, BRAF, MSI, Wnt signalling. Received: April 07, 2016 Accepted: September 02, 2016 Published: September 20 ...
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48 Reduced Frequency and Prognostic Significance of Ring ...
https://www.liebertpub.com/doi/10.1089/dna.2019.4645
Furthermore, we also found that an SNP (rs2257205) of the RNF43 X117 site ... Colorectal cancer (CRC), a malignant tumor derived from the ...
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49 Multi gene mutation signatures in colorectal cancer patients
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-021-08108-9
Identifying gene mutation signatures will enable a better understanding for the occurrence and development of colorectal cancer (CRC), ...
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50 wnt siganling Archives - Madelon Maurice lab
https://madelonmauricelab.nl/tag/wnt-siganling/
Mutations in RNF43 are found in a variety of cancer types, including colorectal, gastric, endometrial, and pancreatic cancer. Mutations that ...
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51 Not All Wnt Activation Is Equal: Ligand-Dependent versus ...
https://www.mdpi.com/2072-6694/12/11/3355/htm
Wnt signaling is ubiquitously activated in colorectal tumors and driver ... For tumor suppressors APC and RNF43, we only consider protein-truncating ...
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52 RNF43 | Homo sapiens gene - Alliance of Genome Resources
https://www.alliancegenome.org/gene/HGNC:18505
Biomarker of colon cancer; high grade glioma; intrahepatic cholangiocarcinoma; stomach cancer; and stomach carcinoma. RGD Description.
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53 The Role of Damaged DNA Binding Protein 2 in Colon Cancer
https://indigo.uic.edu/articles/thesis/The_Role_of_Damaged_DNA_Binding_Protein_2_in_Colon_Cancer/10802456
Here we report that the damage-specific DNA-binding protein DDB2 is critical for β-catenin-mediated activation of RNF43, which restricts Wnt-signaling by ...
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54 Commonly observed RNF43 mutations retain functionality in ...
https://pure.eur.nl/en/publications/commonly-observed-rnf43-mutations-retain-functionality-in-attenua
We could not confirm previous reports linking RNF43 to p53 and E-cadherin breakdown. Our data also suggest that only colorectal cancer cells ...
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55 RNF43 is mutated less frequently in Lynch Syndrome ...
https://espace.library.uq.edu.au/view/UQ:637816
The WNT signaling pathway is commonly altered during colorectal cancer development. The E3 ubiquitin ligase, RNF43, negatively regulates the ...
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56 69.05 Survival Outcome of RNF43 Mutant-type Differs ...
https://www.asc-abstracts.org/abs2019/69-05-survival-outcome-of-rnf43-mutant-type-differs-between-right-sided-and-left-sided-colorectal-cancer/
Introduction: Right-sided colorectal cancer (CRC) demonstrates ... and RNF43 mutation associates with tumor biology of right-sided CRC.
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57 Protein Cell - Frontiers Journals of Higher Education Press
https://journal.hep.com.cn/pac/EN/10.1007/s13238-020-00691-0
Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma.
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58 RNF43 is frequently mutated in colorectal and endometrial cancers ...
https://www.wikidata.org/wiki/Q34817306
RNF43 is frequently mutated in colorectal and endometrial cancers ; Spanish · artículo científico publicado en 2014 ; Traditional Chinese · 2014年學術文章 ; Chinese.
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59 RNF43 (S-16): sc-165398 - Santa Cruz Biotechnology
https://datasheets.scbt.com/sc-165398.pdf
lung, colon and kidney. RNF43 functions as a cytotoxic T lymphocyte tumor antigen, and is therefore considered a target for cancer immunotherapy. The.
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60 Molecular mechanisms underlying the resistance of BRAF ...
https://journals.sagepub.com/doi/full/10.1177/17588359221105022
Molecular targeted therapy of BRAF-mutant colorectal cancer ... Those with RNF43 mutations (n = 8) were more likely to achieve clinical benefit from ...
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61 RNF43 Back - Tumor Portal
http://www.tumorportal.org/view?geneSymbol=RNF43
RNF43 is a HAP95 (AKAP8L; MIM 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer (Yagyu et al., 2004 [PubMed ...
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62 RNF43 frameshift mutants show enhanced WNT siganling
https://reactome.org/content/detail/R-HSA-5340587
› content › detail › R-HSA-5340587
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63 Loss of endogenous RNF43 function enhances proliferation ...
https://academic.oup.com/carcin/article-abstract/40/4/551/5149556
Notably, this was independent of elevated Wnt signalling. Together, our results show that RNF43 plays a tumour suppressive role in gastric and colorectal cancer ...
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64 Moving upstream in the war on WNTs - JCI
https://www.jci.org/articles/view/80819
Cholangiocarcinoma is a relatively rare cancer of the biliary ducts ... RNF43 is frequently mutated in colorectal and endometrial cancers.
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65 Scientists unravel the molecular mechanism underlying the ...
https://www.news-medical.net/news/20200915/Scientists-unravel-the-molecular-mechanism-underlying-the-causes-of-colorectal-cancer.aspx
It functions as a negative regulator of the Wnt signaling pathway, and mutations of RNF43 are commonly found in colorectal cancer.
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66 Genomic Profiling Reveals the Molecular Landscape of ...
https://www.frontiersin.org/articles/10.3389/fgene.2021.608742/full
In colorectal and gastric cancers, the molecular characteristics of ... preclinical cancer models have shown the responsiveness of RNF43 ...
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67 RNF43 Research Products - Novus Biologicals
https://www.novusbio.com/common-name/rnf43
RNF43 is a HAP95 (AKAP8L; MIM 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer (Yagyu et al., 2004 (PubMed ...
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68 RNF43 mutation is associated with aggressive tumor biology ...
https://www.ingentaconnect.com/content/sp/or/2020/00000043/00000006/art00012
Right-sided colorectal cancer (RCRC) demonstrates worse survival outcome compared with left-sided CRC (LCRC). Recently, the importance of ...
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69 RNF43 - LSBio
https://www.lsbio.com/targets/rnf43/g113266
Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers.
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70 Researchers Identify Mutation That May Serve as a Biomarker ...
https://www.cancertherapyadvisor.com/home/cancer-topics/gastrointestinal-cancers/researchers-identify-mutation-that-may-serve-as-a-biomarker-for-colorectal-endometrial-cancers/
A new mutation has been identified in colorectal and endometrial cancers that may ... They found the RNF43 mutation is 18.9% of tumors.
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71 Candidate genes. - GeneDistiller
https://www.genedistiller.org/GD/results.cgi?show_interaction=1&show_hpo=1&show_pathways=1&txid=9606&order=start_pos&show_generifs=1&show_mgd_phenotypes=1&show_GO=1&show_pfam=1&show_transcripts=1&show_omim=1&show_synonyms=1&show_interpro=1&show_paralogs=1&show_proteinfamilies=1&genesymbol=RNF43
DESCRIPTION RNF43 is a HAP95 (AKAP8L; 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer (Yagyu et al., 2004; ...
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72 RNF43 is frequently mutated in colorectal ... - Monash University
https://research.monash.edu/en/publications/rnf43-is-frequently-mutated-in-colorectal-and-endometrial-cancers
These results indicate that RNF43 is one of the most commonly mutated genes in colorectal and endometrial cancers.
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73 Invitae Colorectal Cancer Panel | Test catalog
https://www.invitae.com/physician/tests/01251
Genetic testing for up to 30 genes associated with inherited colorectal cancer. Some genes are also associated with an increased risk for extracolonic ...
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74 cBioPortal for Cancer Genomics
https://www.cbioportal.org/
The cBioPortal for Cancer Genomics provides visualization, analysis and download of large-scale cancer genomics data sets.
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75 Pancreatic cancer - Wikipedia
https://en.wikipedia.org/wiki/Pancreatic_cancer
Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass.
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76 Frequent RNF43 mutation contributes to ... - ResearchPad
https://www.researchpad.co/article/doi/10.1007/s13238-020-00691-0
Signet-ring cell carcinoma (SRCC) is a rare subtype of colorectal cancer (CRC) characterized histologically by the accumulation of mucins in the ...
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77 Wntシグナル研究の歴史と展望∼その足跡と未来 - 生化学
https://seikagaku.jbsoc.or.jp/10.14952/SEIKAGAKU.2020.920498/data/index.pdf
(mouse mammary tumor virus)であると考えられた11). 1950∼1960年代にかけて,種々の動物から ... finger 3)とそのホモログのRNF43(ring finger protein 43).
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78 City of Hope develops cancer-killing virus to attack colon cancer
https://www.cityofhope.org/breakthroughs/city-of-hope-develops-cancer-killing-virus-for-colon-cancer
› breakthroughs › city-of-h...
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79 Colon Cancer Treatment - Vanderbilt-Ingram Cancer Center
https://www.vicc.org/cancer-info/adult-colon-cancer
Signs of colon cancer include blood in the stool or a change in bowel habits. Tests that examine the colon and rectum are used to diagnose colon ...
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80 Richard Kim, MD, Highlights the Rationale for Assessing ...
https://www.cancernetwork.com/view/richard-kim-md-highlights-the-rationale-for-assessing-pembrolizumab-plus-standard-chemo-in-metastatic-mss-pmmr-crc
During the 2022 American Society of Clinical Oncology Annual Meeting, ... pembrolizumab plus chemotherapy in metastatic colorectal cancer.
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81 Biomarkers - Bowel Cancer Australia
https://www.bowelcanceraustralia.org/biomarkers
That means your tumour might not respond to the same treatment that another bowel cancer patient receives. · Biomarker testing is done by analysing biopsies to ...
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82 BRAF V600E Mutations Impact on Tumor Microenvironment in ...
https://www.hmpgloballearningnetwork.com/site/onc/videos/impact-coexisting-braf-v600e-mutations-tumor-microenvironment-msi-high-or-mmr
Mohamed Salem, MD, discusses findings from a study exploring the impact of a BRAF V600E mutation on the tumor microenvironment in colorectal ...
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83 WNT Signaling - Page 8 - Google Books Result
https://books.google.com/books?id=7WU6DwAAQBAJ&pg=PA8&lpg=PA8&dq=rnf43+colon+cancer&source=bl&ots=TAc0CSkBVY&sig=ACfU3U1HKabgOFKBme86N1qh7H8KveHqdA&hl=en&sa=X&ved=2ahUKEwiPteTZvcT7AhXcrmoFHQzlC0oQ6AF6BQiyAhAD
There are many questions that need to be answered to better understand the colon cancer initiation and progression to malignancy. 3.4 RNF43/ ...
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