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Google Keyword Rankings for : who invented knockout mice
1
Three scientists who invented gene knockout technology won ...
https://www.discoverymedicine.com/Benjamin-Yang/2009/05/10/three-scientists-who-invented-gene-knockout-technology-won-lasker-basic-medical-research-award/
Evans, Oliver Smithies, and Mario R. Capecchi for their pioneering work on gene targeting to create knockout mice. Their brilliant work in the ...
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https://www.discoverymedicine.com/Benjamin-Yang/2009/05/10/three-scientists-who-invented-gene-knockout-technology-won-lasker-basic-medical-research-award/
Evans, Oliver Smithies, and Mario R. Capecchi for their pioneering work on gene targeting to create knockout mice. Their brilliant work in the ...
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2
The Earliest Knockouts - PMC - NCBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982188/
The homozygous β2M-knockout mice were healthy, and both males and females were fertile. The knockout mice had apparently normal development, ruling out previous ...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982188/
The homozygous β2M-knockout mice were healthy, and both males and females were fertile. The knockout mice had apparently normal development, ruling out previous ...
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3
Knockout Mice Fact Sheet
https://www.genome.gov/about-genomics/fact-sheets/Knockout-Mice-Fact-Sheet
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an ...
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https://www.genome.gov/about-genomics/fact-sheets/Knockout-Mice-Fact-Sheet
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an ...
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4
Nobel prize for scientist who gave the world the knockout mouse
https://www.theguardian.com/science/2007/oct/09/2
Sir Martin Evans, a professor of mammalian genetics at Cardiff University, became the first scientist to isolate stem cells from mouse embryos ...
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https://www.theguardian.com/science/2007/oct/09/2
Sir Martin Evans, a professor of mammalian genetics at Cardiff University, became the first scientist to isolate stem cells from mouse embryos ...
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5
Knockout mice as models for human disease
https://laskerfoundation.org/winners/knockout-mice-as-models-for-human-disease/
The first knockout mice constructed by gene targeting were published in 1989, and the rest is history. More than 4000 different knockout mice ...
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https://laskerfoundation.org/winners/knockout-mice-as-models-for-human-disease/
The first knockout mice constructed by gene targeting were published in 1989, and the rest is history. More than 4000 different knockout mice ...
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6
Generation of Knockout Mice | Cyagen
https://www.cyagen.com/us/en/community/technical-bulletin/how-knockout-mice-developed.html
In 1981 Sir Martin J. Evans managed to cultivate embryonic stem cells from mice, which paved the way to producing live mice with modified ...
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https://www.cyagen.com/us/en/community/technical-bulletin/how-knockout-mice-developed.html
In 1981 Sir Martin J. Evans managed to cultivate embryonic stem cells from mice, which paved the way to producing live mice with modified ...
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7
1. Nobel knockout! - The Why Files
https://whyfiles.org/268knockouts/
Then, between 1982 and 1989, Capecchi, Smithies and Evans invented and combined elements of a precise targeting system that can make mice with ...
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https://whyfiles.org/268knockouts/
Then, between 1982 and 1989, Capecchi, Smithies and Evans invented and combined elements of a precise targeting system that can make mice with ...
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8
Rapid generation of conditional knockout mice using the ...
https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-021-00859-7
The invention of Embryonic stem (ES) cell-based gene targeting technology in mice and conditional knockout systems using Cre/LoxP has led to ...
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https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-021-00859-7
The invention of Embryonic stem (ES) cell-based gene targeting technology in mice and conditional knockout systems using Cre/LoxP has led to ...
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9
In the fight over the CRISPR patent, JAX customers win
https://www.jax.org/news-and-insights/jax-blog/2017/january/crispr-patent
... the CRISPR Cas9 process to use new mouse models created at JAX ... that it would be interpreted as an invention for editing any DNA.
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https://www.jax.org/news-and-insights/jax-blog/2017/january/crispr-patent
... the CRISPR Cas9 process to use new mouse models created at JAX ... that it would be interpreted as an invention for editing any DNA.
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10
Rapid generation of conditional knockout mice using ... - bioRxiv
http://biorxiv.org/cgi/reprint/2021.05.09.443330v1
The invention of ES cell-based gene targeting technology in mice and conditional knockout. 20 systems using Cre/Loxp have led to ...
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http://biorxiv.org/cgi/reprint/2021.05.09.443330v1
The invention of ES cell-based gene targeting technology in mice and conditional knockout. 20 systems using Cre/Loxp have led to ...
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11
US5616491A - Knockout mice - Google Patents
https://patents.google.com/patent/US5616491A/en
In one aspect, the invention provides a mouse and its progeny having a suppressed level of expression of the gene encoding CD28 on T cells.
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https://patents.google.com/patent/US5616491A/en
In one aspect, the invention provides a mouse and its progeny having a suppressed level of expression of the gene encoding CD28 on T cells.
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12
Fgl-2 knockout mice - Justia Patents
https://patents.justia.com/patent/6642433
A knockout mouse in which the Fgl-2 gene has been suppressed is ... The present invention relates to mammals and cell lines in which the ...
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https://patents.justia.com/patent/6642433
A knockout mouse in which the Fgl-2 gene has been suppressed is ... The present invention relates to mammals and cell lines in which the ...
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13
The 2007 Nobel Prize in Physiology or Medicine - Press release
https://www.nobelprize.org/prizes/medicine/2007/press-release/
Birth of the knockout mouse – the beginning of a new era in genetics. The first reports in which homologous recombination in ES cells was used ...
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https://www.nobelprize.org/prizes/medicine/2007/press-release/
Birth of the knockout mouse – the beginning of a new era in genetics. The first reports in which homologous recombination in ES cells was used ...
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14
CRISPR/Cas9-mediated gene knockout in the mouse brain ...
https://www.nature.com/articles/srep20611
By combining the CRISPR/Cas9 system and in utero electroporation, which is a recently invented, rapid and efficient technique to deliver ...
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https://www.nature.com/articles/srep20611
By combining the CRISPR/Cas9 system and in utero electroporation, which is a recently invented, rapid and efficient technique to deliver ...
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15
PSU No. 3668 “CYLD Knockout Mouse”
https://www.research.psu.edu/sites/default/files/cyld-knockout-mouse-1.pdf
Non-Confidential Description - PSU No. 3668. “CYLD Knockout Mouse”. Keywords/Field of Invention: Cylindromatosis (CYLD), Ubiquitination, Tumor Suppression,.
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https://www.research.psu.edu/sites/default/files/cyld-knockout-mouse-1.pdf
Non-Confidential Description - PSU No. 3668. “CYLD Knockout Mouse”. Keywords/Field of Invention: Cylindromatosis (CYLD), Ubiquitination, Tumor Suppression,.
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16
It's a knockout! Pioneering mouse molecular genetics - YouTube
https://www.youtube.com/watch?v=grPwcefNYMo
The Genetic Basis of Stuff and Things
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https://www.youtube.com/watch?v=grPwcefNYMo
The Genetic Basis of Stuff and Things
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17
"Knockout mice" designers win Nobel Prize - Reuters
https://www.reuters.com/article/us-nobel-medicine/knockout-mice-designers-win-nobel-prize-idUSL084361320071009
Evans, of Cardiff University, laid the groundwork for making so-called knockout mice when he discovered that days-old embryos are made up of ...
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https://www.reuters.com/article/us-nobel-medicine/knockout-mice-designers-win-nobel-prize-idUSL084361320071009
Evans, of Cardiff University, laid the groundwork for making so-called knockout mice when he discovered that days-old embryos are made up of ...
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18
Little mouse, big science - Yale School of Medicine
https://medicine.yale.edu/news-article/little-mouse-big-science/
Geneticist Tian Xu has found a way to make knockout mice quickly and cheaply. By finding genes and discerning their functions, he hopes to find cures for.
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https://medicine.yale.edu/news-article/little-mouse-big-science/
Geneticist Tian Xu has found a way to make knockout mice quickly and cheaply. By finding genes and discerning their functions, he hopes to find cures for.
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19
The origins of oncomice: a history of the first transgenic mice ...
http://genesdev.cshlp.org/content/21/18/2258.long
Richard Palmiter, Ralph Brinster, and transgenic mice developing brain tumors. (Top) Palmiter and Brinster are shown at their first meeting in person, in ...
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http://genesdev.cshlp.org/content/21/18/2258.long
Richard Palmiter, Ralph Brinster, and transgenic mice developing brain tumors. (Top) Palmiter and Brinster are shown at their first meeting in person, in ...
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20
Genome Editing B.C. (Before CRISPR)
https://www.genengnews.com/insights/genome-editing-b-c-before-crispr/
Many elegant technical improvements are invented by the mouse research ... of knockout mouse ES cells, and mice genetically engineered in ...
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https://www.genengnews.com/insights/genome-editing-b-c-before-crispr/
Many elegant technical improvements are invented by the mouse research ... of knockout mouse ES cells, and mice genetically engineered in ...
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21
Lexicon Genetics creating schizophrenic knockout mice
https://www.bioprocessonline.com/doc/lexicon-genetics-creating-schizophrenic-knock-0001
Lexicon Genetics uses large-scale knockout mouse technology to define the functions of genes for drug discovery. Lexicon has invented high-throughput gene ...
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https://www.bioprocessonline.com/doc/lexicon-genetics-creating-schizophrenic-knock-0001
Lexicon Genetics uses large-scale knockout mouse technology to define the functions of genes for drug discovery. Lexicon has invented high-throughput gene ...
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22
Histone deacetylase 1/2 (HDAC 1/2) double knockout mouse ...
https://ximbio.com/reagent/158385/histone-deacetylase-12-hdac-12-double-knockout-mouse-embryonic-stem-cell-line
Histone deacetylase 1/2 (HDAC 1/2) double knockout mouse embryonic stem cell line. Invented by Shaun Cowley. Invented at University Of Leicester. Datasheet.
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https://ximbio.com/reagent/158385/histone-deacetylase-12-hdac-12-double-knockout-mouse-embryonic-stem-cell-line
Histone deacetylase 1/2 (HDAC 1/2) double knockout mouse embryonic stem cell line. Invented by Shaun Cowley. Invented at University Of Leicester. Datasheet.
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23
RBRC02344
https://mus.list.brc.riken.jp/en/id/rbrc02344/
This conditional knockout mice have a loxP-flanked Nf2 allele. ... Moreover, if the research results in a potential invention or a substance that may have ...
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https://mus.list.brc.riken.jp/en/id/rbrc02344/
This conditional knockout mice have a loxP-flanked Nf2 allele. ... Moreover, if the research results in a potential invention or a substance that may have ...
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24
Migration inhibitory factor (MIF) knockout mouse
https://otd.harvard.edu/explore-innovation/technologies/migration-inhibitory-factor-mif-knockout-mouse/
The invention is a mouse that is homozygous null for the Mif gene (MIF-/- KO mice). A neomycin resistance cassette replaced a genomic fragment containing part ...
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https://otd.harvard.edu/explore-innovation/technologies/migration-inhibitory-factor-mif-knockout-mouse/
The invention is a mouse that is homozygous null for the Mif gene (MIF-/- KO mice). A neomycin resistance cassette replaced a genomic fragment containing part ...
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25
2 High-Throughput Gene Knockouts and Phenotyping in Mice
http://eknygos.lsmuni.lt/springer/29/27-44.pdf
Deltagen believes that its knockout mouse lines and related phe- notypic information have several advantages ... Proprietary methods invented at Deltagen.
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http://eknygos.lsmuni.lt/springer/29/27-44.pdf
Deltagen believes that its knockout mouse lines and related phe- notypic information have several advantages ... Proprietary methods invented at Deltagen.
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26
knockout mice for different genes and their use for gene ...
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2008042469
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function.
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https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2008042469
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function.
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27
Cholinergic Receptor Knockout Mice - Abstract - Europe PMC
https://europepmc.org/article/nbk/nbk2517
Therefore, in rodents, mouse is a better species for employing the knockout approach compared with rat. In theory, knockout (KO) mice contain a targeted gene ...
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https://europepmc.org/article/nbk/nbk2517
Therefore, in rodents, mouse is a better species for employing the knockout approach compared with rat. In theory, knockout (KO) mice contain a targeted gene ...
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28
Generating Mouse Models Using CRISPR/Cas9 - Addgene Blog
https://blog.addgene.org/generating-mouse-models-using-crispr/cas9
In the 1980s, gene targeting technology was invented to introduce specific changes into the mouse genome. With these early technologies, ...
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https://blog.addgene.org/generating-mouse-models-using-crispr/cas9
In the 1980s, gene targeting technology was invented to introduce specific changes into the mouse genome. With these early technologies, ...
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29
Lexicon Genetics' Knockout Technology Used To Develop ...
https://www.lexpharma.com/media-center/news/604-lexicon-genetics-knockout-technology-used-to-develop-first-animal-model-for-canavan-disease
With the high degree of genetic similarity between mice and humans, knockout mouse models have become the gold standard for genome-based drug discovery efforts ...
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https://www.lexpharma.com/media-center/news/604-lexicon-genetics-knockout-technology-used-to-develop-first-animal-model-for-canavan-disease
With the high degree of genetic similarity between mice and humans, knockout mouse models have become the gold standard for genome-based drug discovery efforts ...
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30
Overview: Generation of Gene Knockout Mice | Request PDF
https://www.researchgate.net/publication/26790356_Overview_Generation_of_Gene_Knockout_Mice
› publication › 26790356_O...
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https://www.researchgate.net/publication/26790356_Overview_Generation_of_Gene_Knockout_Mice
› publication › 26790356_O...
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31
Smooth Muscle Cells in Atherosclerosis Originate From the ...
https://www.ahajournals.org/doi/10.1161/01.atv.0000247243.48542.9d
Objective— Recent studies of bone marrow (BM)-transplanted apoE knockout (apoE−/−) mice have concluded that a substantial fraction of smooth muscle cells ...
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https://www.ahajournals.org/doi/10.1161/01.atv.0000247243.48542.9d
Objective— Recent studies of bone marrow (BM)-transplanted apoE knockout (apoE−/−) mice have concluded that a substantial fraction of smooth muscle cells ...
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32
Shank3 knockout mice as a model for autism - Duke OTC
https://otc.duke.edu/technologies/shank3-knockout-mice-as-a-model-for-autism/
Inventor(s) · Feng, Guoping · Feliciano, Catia · Fu, Zhanyan · Peca Sivestre, Joao · Ting, Jonathan · Wang, Wenting · Wells, Michael ...
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https://otc.duke.edu/technologies/shank3-knockout-mice-as-a-model-for-autism/
Inventor(s) · Feng, Guoping · Feliciano, Catia · Fu, Zhanyan · Peca Sivestre, Joao · Ting, Jonathan · Wang, Wenting · Wells, Michael ...
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33
ABCD1 Knockout Mouse - Technology
https://jhu.technologypublisher.com/technology/23284
Invention novelty: This invention is a mouse model for X-linked adrenoleukodystrophy (XALD). The mouse model is developed to facilitate ...
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https://jhu.technologypublisher.com/technology/23284
Invention novelty: This invention is a mouse model for X-linked adrenoleukodystrophy (XALD). The mouse model is developed to facilitate ...
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34
Generation of Knockout Mice Using CRISPR/Cas9 Genome ...
https://www.utsouthwestern.edu/edumedia/edufiles/about_us/admin_offices/technology_development/available_technologies/utsd-3049.pdf
SUMMARY: This invention is a method to rapidly and easily generate germline mutations in the mouse genome, which can be utilized to generate ...
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https://www.utsouthwestern.edu/edumedia/edufiles/about_us/admin_offices/technology_development/available_technologies/utsd-3049.pdf
SUMMARY: This invention is a method to rapidly and easily generate germline mutations in the mouse genome, which can be utilized to generate ...
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35
Rapid generation of conditional knockout mice using ... - Gale
https://go.gale.com/ps/i.do?id=GALE%7CA678037617&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=17566606&p=HRCA&sw=w
The invention of Embryonic stem (ES) cell-based gene targeting technology in mice and conditional knockout systems using Cre/LoxP has led to breakthroughs ...
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https://go.gale.com/ps/i.do?id=GALE%7CA678037617&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=17566606&p=HRCA&sw=w
The invention of Embryonic stem (ES) cell-based gene targeting technology in mice and conditional knockout systems using Cre/LoxP has led to breakthroughs ...
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36
knockout mouse | medical research - Encyclopedia Britannica
https://www.britannica.com/science/knockout-mouse
This initial success gave rise to “knockout mice,” laboratory mice that had been altered by deactivating or “knocking out” a specific gene for the purpose of ...
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https://www.britannica.com/science/knockout-mouse
This initial success gave rise to “knockout mice,” laboratory mice that had been altered by deactivating or “knocking out” a specific gene for the purpose of ...
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37
3 Win Nobel in Medicine for Gene Technology
https://www.nytimes.com/2007/10/09/science/09nobel.html
After the first decoding of the mouse and human genomes in 2001 yielded thousands of new genes of unknown function, knockout mice became a prime ...
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https://www.nytimes.com/2007/10/09/science/09nobel.html
After the first decoding of the mouse and human genomes in 2001 yielded thousands of new genes of unknown function, knockout mice became a prime ...
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38
Retrospective on reverse genetics in mice around the world ...
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1440-169X.2008.01004.x
that led to the “knockout (KO) mouse” has changed our understanding of normal development and ... The method of injecting DNA into nuclei was invented.
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https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1440-169X.2008.01004.x
that led to the “knockout (KO) mouse” has changed our understanding of normal development and ... The method of injecting DNA into nuclei was invented.
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39
290910 Triple knockout mouse FINAL - Crescendo Biologics
https://www.crescendobiologics.com/wp-content/uploads/2016/03/20100929-Crescendo-Press-Release-Triple-Knockout-Mouse.pdf
Crescendo Biologics Announces First 'Triple Knockout' Mouse ... Crescendo's technologies were invented by scientists at the Babraham Institute, Cambridge.
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https://www.crescendobiologics.com/wp-content/uploads/2016/03/20100929-Crescendo-Press-Release-Triple-Knockout-Mouse.pdf
Crescendo Biologics Announces First 'Triple Knockout' Mouse ... Crescendo's technologies were invented by scientists at the Babraham Institute, Cambridge.
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40
Of mice and CRISPR - EMBO Press
https://www.embopress.org/doi/10.15252/embr.201643717
The invention of polymerase chain reaction dramatically expanded the utility ... by stacking second mutations introduced by CRISPR into a viable knockout.
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https://www.embopress.org/doi/10.15252/embr.201643717
The invention of polymerase chain reaction dramatically expanded the utility ... by stacking second mutations introduced by CRISPR into a viable knockout.
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41
Questions and Answers about CRISPR | Broad Institute
https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/questions-and-answers-about-crispr
› project-spotlight › que...
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https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/questions-and-answers-about-crispr
› project-spotlight › que...
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42
FLEx Technology | Your solution to induce a point mutation
https://www.genoway.com/technologies/ssr/flex-inducible-point-mutation.htm
FLEx technology was invented by Prof. Chambon, Dr. Schnütgen and Dr. Ghyselinck at the Institut de Génétique et de Biologie Moléculaire et Cellulaire (France).
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https://www.genoway.com/technologies/ssr/flex-inducible-point-mutation.htm
FLEx technology was invented by Prof. Chambon, Dr. Schnütgen and Dr. Ghyselinck at the Institut de Génétique et de Biologie Moléculaire et Cellulaire (France).
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43
Generation of Inducible BCL11B Knockout in TAL1/LMO1 ...
https://www.mdpi.com/1422-0067/23/9/4932/htm
The mouse model of inducible BCL11B knockout we generated can be used to study the role ... Since, to date, no specific BCL11B inhibitor has been invented, ...
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https://www.mdpi.com/1422-0067/23/9/4932/htm
The mouse model of inducible BCL11B knockout we generated can be used to study the role ... Since, to date, no specific BCL11B inhibitor has been invented, ...
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44
Dicer knockout Mouse embryonic stem cells (NBP1-96751)
https://www.novusbio.com/products/dicer-knockout-mouse-embryonic-stem-cells_nbp1-96751
The Dicer knockout Mouse embryonic stem cells were derived from Dicer knockout mice. Dicer is essential for the processing of small non-coding RNAs ...
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https://www.novusbio.com/products/dicer-knockout-mouse-embryonic-stem-cells_nbp1-96751
The Dicer knockout Mouse embryonic stem cells were derived from Dicer knockout mice. Dicer is essential for the processing of small non-coding RNAs ...
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45
Gene Targeting Using Homologous Recombination ... - Frontiers
https://www.frontiersin.org/articles/10.3389/fgene.2016.00043/full
Thus, the mutation induced with this technology was called null mutation, and the transgenic mouse carrying such a mutation, the knock out or ...
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https://www.frontiersin.org/articles/10.3389/fgene.2016.00043/full
Thus, the mutation induced with this technology was called null mutation, and the transgenic mouse carrying such a mutation, the knock out or ...
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46
Development and Characterization of the SLC46A3 Knockout ...
https://techtransfer.cancer.gov/availabletechnologies/e-152-2021
This invention is available for licensing. ... The SLC46A3 knockout mouse line is therefore an effective tool to study TCDD-induced lipid ...
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https://techtransfer.cancer.gov/availabletechnologies/e-152-2021
This invention is available for licensing. ... The SLC46A3 knockout mouse line is therefore an effective tool to study TCDD-induced lipid ...
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47
The Rise of the Mouse | Discover Magazine
https://www.discovermagazine.com/mind/the-rise-of-the-mouse
Newsletter · But this is all out of date. Nowadays, mice are the most popular lab animals. · Knockout mice were "invented" in 1989, and the ...
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https://www.discovermagazine.com/mind/the-rise-of-the-mouse
Newsletter · But this is all out of date. Nowadays, mice are the most popular lab animals. · Knockout mice were "invented" in 1989, and the ...
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48
IL-1RA Gene Knockout has no Effect on Development of Type ...
https://www.augusta.edu/curs/gene.knockout.pdf
Knock out mice: did not have the IL-1RA gene. 3. Heterozygous mice: carriers of ... https://patents.justia.com/inventor/sharad-purohit. • Type 1 diabetes.
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https://www.augusta.edu/curs/gene.knockout.pdf
Knock out mice: did not have the IL-1RA gene. 3. Heterozygous mice: carriers of ... https://patents.justia.com/inventor/sharad-purohit. • Type 1 diabetes.
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49
Rescue of the Stargardt phenotype in Abca4 knockout ... - PNAS
https://www.pnas.org/doi/abs/10.1073/pnas.1506960112
The mechanism behind lipofuscin formation in the retina or in any tissue is poorly understood. Here we show in mice that the dimerization of vitamin A is ...
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https://www.pnas.org/doi/abs/10.1073/pnas.1506960112
The mechanism behind lipofuscin formation in the retina or in any tissue is poorly understood. Here we show in mice that the dimerization of vitamin A is ...
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50
Cbl-b conditional knockout mouse - UNeMed
https://www.unemed.com/product/cbl-b-conditional-knockout-mouse
Researchers at the University of Nebraska Medical Center have created a conditional knockout Cbl-b mouse model. This novel mouse model allows for tissue ...
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https://www.unemed.com/product/cbl-b-conditional-knockout-mouse
Researchers at the University of Nebraska Medical Center have created a conditional knockout Cbl-b mouse model. This novel mouse model allows for tissue ...
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51
Review paper Apolipoprotein E knockout mice - Termedia
https://www.termedia.pl/-Review-paper-Apolipoprotein-E-knockout-mice-r-nan-experimental-model-to-study-inflammatory-r-nmechanisms-of-atherosclerosis-and-to-screen-r-na-putative-anti-atherogenic-properties-of-drugs,10,18375,1,1.html
Such evidence was delivered by the use of a new technique of gene targeting, for the invention of which Mario R. Capecchi (Italy), Martin J.
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https://www.termedia.pl/-Review-paper-Apolipoprotein-E-knockout-mice-r-nan-experimental-model-to-study-inflammatory-r-nmechanisms-of-atherosclerosis-and-to-screen-r-na-putative-anti-atherogenic-properties-of-drugs,10,18375,1,1.html
Such evidence was delivered by the use of a new technique of gene targeting, for the invention of which Mario R. Capecchi (Italy), Martin J.
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52
10 breakthroughs in stem cell research - BHF
https://www.bhf.org.uk/informationsupport/heart-matters-magazine/research/breakthroughs-in-stem-cell-research
Knockout mice are now considered vital to disease research. Thanks to this discovery, BHF Professor Hugh Watkins, Director of the British Heart Foundation ...
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https://www.bhf.org.uk/informationsupport/heart-matters-magazine/research/breakthroughs-in-stem-cell-research
Knockout mice are now considered vital to disease research. Thanks to this discovery, BHF Professor Hugh Watkins, Director of the British Heart Foundation ...
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53
'Knockout mice' study wins Nobel Medicine Prize - ABC News
https://www.abc.net.au/news/2007-10-08/knockout-mice-study-wins-nobel-medicine-prize/692744
The discovery is technically called gene targeting but is commonly known as gene 'knockout'. The Nobel jury says engineered mice provide ...
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https://www.abc.net.au/news/2007-10-08/knockout-mice-study-wins-nobel-medicine-prize/692744
The discovery is technically called gene targeting but is commonly known as gene 'knockout'. The Nobel jury says engineered mice provide ...
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54
Transgenic knockout animals lacking IgG3 - Google Patents
https://www.google.com/patents/US6080910
The present invention provides non-human transgenic animals in which an antibody ... mice, while homozygous knockouts had only an 8.9 kb DNA fragment (FIG.
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https://www.google.com/patents/US6080910
The present invention provides non-human transgenic animals in which an antibody ... mice, while homozygous knockouts had only an 8.9 kb DNA fragment (FIG.
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55
Mouse Model as a Tool for Spatiotemporal and Lineage ...
http://innovation.columbia.edu/technologies/2998_mouse-model-as-a-tool-for
Lead Inventor: Franklin Costantini, Ph.D. ... In biomedical research, transgenic mouse models are utilized to provide a test subject as a ...
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http://innovation.columbia.edu/technologies/2998_mouse-model-as-a-tool-for
Lead Inventor: Franklin Costantini, Ph.D. ... In biomedical research, transgenic mouse models are utilized to provide a test subject as a ...
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56
Astonishing advances in mouse genetic tools for biomedical ...
https://smw.ch/article/doi/smw.2015.14186
For example, mouse lines with different knock-out alleles of the prion ... the invention of next generation sequencing (NGS) technologies, ...
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https://smw.ch/article/doi/smw.2015.14186
For example, mouse lines with different knock-out alleles of the prion ... the invention of next generation sequencing (NGS) technologies, ...
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57
A New Mouse? Genetically Pliable Stem Cells Could Advance ...
https://www.mskcc.org/news/new-mouse-genetically-pliable-stem-cells-could-advance-research-many-diseases
› ... › In the News
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https://www.mskcc.org/news/new-mouse-genetically-pliable-stem-cells-could-advance-research-many-diseases
› ... › In the News
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58
Knockout mice - Ontario, Cancer Institute - Free Patents Online
https://www.freepatentsonline.com/5616491.html
In other aspects, the invention provides embryonic stem cell lines containing a CD28 or a CD45 exon 6 isoform knockout construct.
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https://www.freepatentsonline.com/5616491.html
In other aspects, the invention provides embryonic stem cell lines containing a CD28 or a CD45 exon 6 isoform knockout construct.
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59
CRISPR Scientists, Pioneers, and Leaders: The Real Heroes
https://www.synthego.com/blog/crispr-scientists
Emmanuelle Charpentier is the co-inventor of CRISPR. Together with Dr. Doudna, Dr. Charpentier was involved in the biochemical characterization ...
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https://www.synthego.com/blog/crispr-scientists
Emmanuelle Charpentier is the co-inventor of CRISPR. Together with Dr. Doudna, Dr. Charpentier was involved in the biochemical characterization ...
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60
It's a knockout | The Economist
https://www.economist.com/science-and-technology/2007/10/11/its-a-knockout
Prizes for genetically disadvantaged mice, computer hard drives and ... a way for the gene-targeting trick invented by Dr Capecchi and Dr ...
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https://www.economist.com/science-and-technology/2007/10/11/its-a-knockout
Prizes for genetically disadvantaged mice, computer hard drives and ... a way for the gene-targeting trick invented by Dr Capecchi and Dr ...
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61
Animal & PDX Models | Fox Chase Cancer Center
https://www.foxchase.org/about-us/research-and-development-alliances/technology-transfer/licensing/animal-models
› about-us › licensing › anim...
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https://www.foxchase.org/about-us/research-and-development-alliances/technology-transfer/licensing/animal-models
› about-us › licensing › anim...
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62
Oliver Smithies, Technologist Behind Knockout Mice, Dies
https://www.the-scientist.com/news-opinion/oliver-smithies-technologist-behind-knockout-mice-dies-32208
Prior to winning a Nobel Prize, Smithies—who also invented starch gel electrophoresis —received a Lasker Basic Medical Research Award in 2001 ...
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https://www.the-scientist.com/news-opinion/oliver-smithies-technologist-behind-knockout-mice-dies-32208
Prior to winning a Nobel Prize, Smithies—who also invented starch gel electrophoresis —received a Lasker Basic Medical Research Award in 2001 ...
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63
Gene Editing Technologies and Use of Recombinant ...
https://www.liebertpub.com/doi/full/10.1177/1535676018797353
In some cases, the genomes of laboratory mice were modified to include the ... genes may have a loss of function (knockouts), expression of ...
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https://www.liebertpub.com/doi/full/10.1177/1535676018797353
In some cases, the genomes of laboratory mice were modified to include the ... genes may have a loss of function (knockouts), expression of ...
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64
A Conversation with CRISPR-Cas9 Inventors Charpentier and ...
https://dnascience.plos.org/2020/10/08/a-conversation-with-crispr-cas9-inventors-charpentier-and-doudna-2/
... and Charpentier “discover” genome editing – they invented it. ... to create the knockout mice that have since served as models for many ...
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https://dnascience.plos.org/2020/10/08/a-conversation-with-crispr-cas9-inventors-charpentier-and-doudna-2/
... and Charpentier “discover” genome editing – they invented it. ... to create the knockout mice that have since served as models for many ...
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65
Mouse and Materials MTA Discussion - INFRAFRONTIER
https://www.infrafrontier.eu/sites/infrafrontier.eu/files/upload/public/pdf/Knowledgebase/Moore_IMPC_May2014.pdf
invention provides transgenic mice comprising mutations in a glucagon receptor ... Glucagon Receptor Knockout Prevents Insulin-Deficient.
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https://www.infrafrontier.eu/sites/infrafrontier.eu/files/upload/public/pdf/Knowledgebase/Moore_IMPC_May2014.pdf
invention provides transgenic mice comprising mutations in a glucagon receptor ... Glucagon Receptor Knockout Prevents Insulin-Deficient.
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66
Rescuing Lethal Phenotypes Induced by Disruption of Genes ...
https://www.biomed.cas.cz/physiolres/pdf/2021/70_3.pdf
Knock-out mice • CRISPR/Cas9 • Lethality • Knock-out rabbits. Corresponding author ... remained unsolved until the invention of two-cell.
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https://www.biomed.cas.cz/physiolres/pdf/2021/70_3.pdf
Knock-out mice • CRISPR/Cas9 • Lethality • Knock-out rabbits. Corresponding author ... remained unsolved until the invention of two-cell.
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67
pml knockout mice: Topics by Science.gov
https://www.science.gov/topicpages/p/pml+knockout+mice
Infection of PML-knockout mice demonstrates that PML/PML-NBs are involved in virus ... focally within the graft by a recently invented collar technique.
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https://www.science.gov/topicpages/p/pml+knockout+mice
Infection of PML-knockout mice demonstrates that PML/PML-NBs are involved in virus ... focally within the graft by a recently invented collar technique.
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68
At Genetic Frontier, the House Mouse Serves Humanity
https://bastiani.biology.utah.edu/courses/3230/DB%20Lecture/Handouts/Lec3%20Cloning,%20gene%20therapy/Mouse%20Model.pdf
Some strains, called knockout mice, have had a specific gene removed, ... The mice can be used to test drugs before they are invented, ...
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https://bastiani.biology.utah.edu/courses/3230/DB%20Lecture/Handouts/Lec3%20Cloning,%20gene%20therapy/Mouse%20Model.pdf
Some strains, called knockout mice, have had a specific gene removed, ... The mice can be used to test drugs before they are invented, ...
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69
CRISPR/Cas9-Mediated Biallelic Knockout of IRX3 Reduces ...
https://pdfs.semanticscholar.org/3407/ff3104308c49b115d19d6c8b10a50f58e9a2.pdf
Since its invention, it has been successfully used for gene editing in Drosophila [7], zebrafish [8], mouse [9,10], rat [11], rabbit [12,13] ...
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https://pdfs.semanticscholar.org/3407/ff3104308c49b115d19d6c8b10a50f58e9a2.pdf
Since its invention, it has been successfully used for gene editing in Drosophila [7], zebrafish [8], mouse [9,10], rat [11], rabbit [12,13] ...
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70
Transgenic animals | Summary - WhatIsBiotechnology.org
https://whatisbiotechnology.org/index.php/science/summary/transgenic/transgenic-animals-have-genes-from-other-species-inserted
The transgenic mice have been genetically modified so that they carry a green fluorescent ... The end result is what is known as a 'knockout' animal.
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https://whatisbiotechnology.org/index.php/science/summary/transgenic/transgenic-animals-have-genes-from-other-species-inserted
The transgenic mice have been genetically modified so that they carry a green fluorescent ... The end result is what is known as a 'knockout' animal.
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71
Crescendo Biologics Announces First 'Triple Knockout' Mouse
https://www.prnewswire.com/news-releases/crescendo-biologics-announces-first-triple-knockout-mouse-103986858.html
This is a significant advance over previous knockout mice which retain ... Crescendo's technologies were invented by scientists at the ...
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https://www.prnewswire.com/news-releases/crescendo-biologics-announces-first-triple-knockout-mouse-103986858.html
This is a significant advance over previous knockout mice which retain ... Crescendo's technologies were invented by scientists at the ...
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72
Follistatin-like protein 1 regulates chondrocyte proliferation ...
https://ard.bmj.com/content/74/7/1467.full.pdf
we used FSTL1 knockout (KO) mice generated in our laboratory. ... agents that bind thereto' (No 8334274) listing RH as an inventor.
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https://ard.bmj.com/content/74/7/1467.full.pdf
we used FSTL1 knockout (KO) mice generated in our laboratory. ... agents that bind thereto' (No 8334274) listing RH as an inventor.
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73
CRISPR reduces autism symptoms in mice - Berkeley News
https://news.berkeley.edu/2018/06/25/crispr-reduces-autism-symptoms-in-mice/
Mice with fragile X syndrome were treated with CRISPR-Cas9 to knock out a gene involved in obsessive behavior and exhibited much less ...
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https://news.berkeley.edu/2018/06/25/crispr-reduces-autism-symptoms-in-mice/
Mice with fragile X syndrome were treated with CRISPR-Cas9 to knock out a gene involved in obsessive behavior and exhibited much less ...
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74
Atg7 cKO mouse
https://www.igakuken.or.jp/english/center/tlo/seeds6_en.pdf
Collaborative research with the inventor or commission of a particular ... We generated conditional knockout mice of Atg7. Atg7 is essential for ATG ...
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https://www.igakuken.or.jp/english/center/tlo/seeds6_en.pdf
Collaborative research with the inventor or commission of a particular ... We generated conditional knockout mice of Atg7. Atg7 is essential for ATG ...
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75
Three Win Nobel for Work on 'Gene Targeting' - NPR
https://www.npr.org/templates/story/story.php?storyId=15100983
KNOX: A knockout mouse that's missing only a certain gene. ... Capecchi invented a way to target single genes and turn them off to see what ...
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https://www.npr.org/templates/story/story.php?storyId=15100983
KNOX: A knockout mouse that's missing only a certain gene. ... Capecchi invented a way to target single genes and turn them off to see what ...
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76
Knockout Mice Win Nobel Prize - Impact Lab
https://www.impactlab.com/2007/10/11/knockout-mice-win-nobel-prize/
In the 1980s, they devised a technique to remove a functioning gene from the mouse's genetic code and replace it with a flawed counterpart to ...
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https://www.impactlab.com/2007/10/11/knockout-mice-win-nobel-prize/
In the 1980s, they devised a technique to remove a functioning gene from the mouse's genetic code and replace it with a flawed counterpart to ...
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77
Mouse Model with a global deletion in the Spag17 gene
https://innovationgateway.vcu.edu/technologies/research/mouse-model-with-a-global-deletion-in-the-spag17-gene-.html
The novel knockout mouse model that was created has a global deletion in the Spag17 gene. Cells deficient in Spag17 express an EGFP fluorophore ...
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https://innovationgateway.vcu.edu/technologies/research/mouse-model-with-a-global-deletion-in-the-spag17-gene-.html
The novel knockout mouse model that was created has a global deletion in the Spag17 gene. Cells deficient in Spag17 express an EGFP fluorophore ...
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78
Impaired von Willebrand factor adhesion and platelet ...
https://ashpublications.org/blood/article/128/12/1642/73137/Impaired-von-Willebrand-factor-adhesion-and
Irregular ECM assembly in TSP2 KO mice results in reduced VWF adhesion and ... factor adhesion and platelet response in thrombospondin-2 knockout mice.
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https://ashpublications.org/blood/article/128/12/1642/73137/Impaired-von-Willebrand-factor-adhesion-and
Irregular ECM assembly in TSP2 KO mice results in reduced VWF adhesion and ... factor adhesion and platelet response in thrombospondin-2 knockout mice.
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79
Why do scientists use mice in medical research?
https://www.blood.ca/en/research/our-research-stories/research-education-discovery/why-do-scientists-use-mice-medical
› research-education-discovery
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https://www.blood.ca/en/research/our-research-stories/research-education-discovery/why-do-scientists-use-mice-medical
› research-education-discovery
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80
modulation of hippocampal synaptic transmission by the peptide
https://www.ideals.illinois.edu/bitstream/handle/2142/110530/COURTNEY-DISSERTATION-2021.pdf?sequence=1
CONTEXTUAL MEMORY IN DIAZEPAM BINDING INHIBITOR KNOCKOUT MICE .....55 ... The hippocampal “trisynaptic circuit,” coined by Per.
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https://www.ideals.illinois.edu/bitstream/handle/2142/110530/COURTNEY-DISSERTATION-2021.pdf?sequence=1
CONTEXTUAL MEMORY IN DIAZEPAM BINDING INHIBITOR KNOCKOUT MICE .....55 ... The hippocampal “trisynaptic circuit,” coined by Per.
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81
What is CRISPR-Cas9? - YourGenome
https://www.yourgenome.org/facts/what-is-crispr-cas9/
Scientists adapted this system so that it could be used in other cells from animals, including mice and humans.
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https://www.yourgenome.org/facts/what-is-crispr-cas9/
Scientists adapted this system so that it could be used in other cells from animals, including mice and humans.
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82
Made to Measure - Proto Magazine
https://protomag.com/medical-ethics/made-to-measure/
Before CRISPR, thousands of strains of mutant “knockout” mice had been ... a co-inventor of the CRISPR technology (pending U.S. Patent and ...
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https://protomag.com/medical-ethics/made-to-measure/
Before CRISPR, thousands of strains of mutant “knockout” mice had been ... a co-inventor of the CRISPR technology (pending U.S. Patent and ...
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83
Explainer: Why scientists sometimes 'knock out' genes
https://www.snexplores.org/article/explainer-why-scientists-sometimes-knock-out-genes
To make a conditional knockout mouse (for example), scientists start with the single cell and insert short portions of DNA on either side of ...
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https://www.snexplores.org/article/explainer-why-scientists-sometimes-knock-out-genes
To make a conditional knockout mouse (for example), scientists start with the single cell and insert short portions of DNA on either side of ...
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84
Applications that make the cut | Laboratory News
http://www.labnews.co.uk/article/2024931/applications_that_make_the_cut
CRISPR wasn't actually invented, it was discovered, ... Cre-LoxP conditional knockout mouse models where a gene is flanked by LoxP sites ...
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http://www.labnews.co.uk/article/2024931/applications_that_make_the_cut
CRISPR wasn't actually invented, it was discovered, ... Cre-LoxP conditional knockout mouse models where a gene is flanked by LoxP sites ...
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85
Same-sex mouse parents give birth via gene editing
https://www.nationalgeographic.com/science/article/news-gene-editing-crispr-mice-stem-cells
This is not the first time that two female mice bore a live mouse pup. In 2004, researchers announced the birth of the first mice from a ...
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https://www.nationalgeographic.com/science/article/news-gene-editing-crispr-mice-stem-cells
This is not the first time that two female mice bore a live mouse pup. In 2004, researchers announced the birth of the first mice from a ...
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86
How a Knockout Mouse is Made: Methods and Procedures
https://www.genetargeting.com/knockout/knockout-mouse-made/
Creating knockout mice can involve different methods and technologies, such as CRISPR and ES cells, for producing the desired gene knockout ...
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https://www.genetargeting.com/knockout/knockout-mouse-made/
Creating knockout mice can involve different methods and technologies, such as CRISPR and ES cells, for producing the desired gene knockout ...
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87
The Mouse That Changed Science
https://www.sciencehistory.org/distillations/podcast/the-mouse-that-changed-science
› distillations › podcast
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https://www.sciencehistory.org/distillations/podcast/the-mouse-that-changed-science
› distillations › podcast
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88
What is fractionation in psychology. seperation of compounds ...
http://application.kurskmed.com/zzdfh/what-is-fractionation-in-psychology.html
It is a technique invented by John Grinder, a Neuro Linguistic ... Fractionation of spatial memory in GRM2/3 (mGlu2/mGlu3) double knockout mice reveals a ...
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http://application.kurskmed.com/zzdfh/what-is-fractionation-in-psychology.html
It is a technique invented by John Grinder, a Neuro Linguistic ... Fractionation of spatial memory in GRM2/3 (mGlu2/mGlu3) double knockout mice reveals a ...
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89
Knockout Mice - Charles River Laboratories
https://www.criver.com/products-services/research-models-services/genetically-engineered-model-services/transgenic-mouse-rat-model-creation/knockout-mice
Knockout Mouse Models. Knockout mice are defined as having a certain gene of interest made inoperative, or "knocked out." Often referred to as KO mice, they ...
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https://www.criver.com/products-services/research-models-services/genetically-engineered-model-services/transgenic-mouse-rat-model-creation/knockout-mice
Knockout Mouse Models. Knockout mice are defined as having a certain gene of interest made inoperative, or "knocked out." Often referred to as KO mice, they ...
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90
Nervous System Diseases: New Insights for the Healthcare ...
https://books.google.com/books?id=Hadz7thzrDkC&pg=PA86&lpg=PA86&dq=who+invented+knockout+mice&source=bl&ots=pVdfITo7Uw&sig=ACfU3U2kHt301n4vGACE2HGVsOen_AgZNQ&hl=en&sa=X&ved=2ahUKEwiVqIPa_8X7AhWAQUEAHVuYBrQQ6AF6BAgsEAM
A receptor .alpha.1 subunit and T-type Ca.sup.2+ channel double knockout mouse, exhibiting essential tremor. “Another object of the present invention is to ...
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https://books.google.com/books?id=Hadz7thzrDkC&pg=PA86&lpg=PA86&dq=who+invented+knockout+mice&source=bl&ots=pVdfITo7Uw&sig=ACfU3U2kHt301n4vGACE2HGVsOen_AgZNQ&hl=en&sa=X&ved=2ahUKEwiVqIPa_8X7AhWAQUEAHVuYBrQQ6AF6BAgsEAM
A receptor .alpha.1 subunit and T-type Ca.sup.2+ channel double knockout mouse, exhibiting essential tremor. “Another object of the present invention is to ...
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91
Neurodegenerative Diseases: New Insights for the Healthcare ...
https://books.google.com/books?id=1LKUNRuF_0IC&pg=PA254&lpg=PA254&dq=who+invented+knockout+mice&source=bl&ots=nDRa1Mvrvv&sig=ACfU3U0Rf0nRwJKzMnTenoORPIZep6HMWA&hl=en&sa=X&ved=2ahUKEwiVqIPa_8X7AhWAQUEAHVuYBrQQ6AF6BAgrEAM
Preferably, the non-human animal is rodent and, most preferably, is mouse. ... hnRNP A1 knockout mice in accordance with one embodiment of this invention.
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https://books.google.com/books?id=1LKUNRuF_0IC&pg=PA254&lpg=PA254&dq=who+invented+knockout+mice&source=bl&ots=nDRa1Mvrvv&sig=ACfU3U0Rf0nRwJKzMnTenoORPIZep6HMWA&hl=en&sa=X&ved=2ahUKEwiVqIPa_8X7AhWAQUEAHVuYBrQQ6AF6BAgrEAM
Preferably, the non-human animal is rodent and, most preferably, is mouse. ... hnRNP A1 knockout mice in accordance with one embodiment of this invention.
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92
Köhler's Invention - Page 167 - Google Books Result
https://books.google.com/books?id=LOZld53Bz5YC&pg=PA167&lpg=PA167&dq=who+invented+knockout+mice&source=bl&ots=lyiKSKsOLs&sig=ACfU3U3z_KyJry7DInf-7SdHF5qzr1rlZA&hl=en&sa=X&ved=2ahUKEwiVqIPa_8X7AhWAQUEAHVuYBrQQ6AF6BAgtEAM
There she had produced IL-4 knockout BALB/c mice and Müller in London tested their resistance to Leishmania. Their results were published under the title: ...
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https://books.google.com/books?id=LOZld53Bz5YC&pg=PA167&lpg=PA167&dq=who+invented+knockout+mice&source=bl&ots=lyiKSKsOLs&sig=ACfU3U3z_KyJry7DInf-7SdHF5qzr1rlZA&hl=en&sa=X&ved=2ahUKEwiVqIPa_8X7AhWAQUEAHVuYBrQQ6AF6BAgtEAM
There she had produced IL-4 knockout BALB/c mice and Müller in London tested their resistance to Leishmania. Their results were published under the title: ...
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93
GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural ...
https://www.eneuro.org/content/4/1/eneuro.0380-16.2017
Fmr1 knockout mice showed increased baseline and auditory-evoked high-frequency ... After all baclofen was not invented or designed for FXS.
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https://www.eneuro.org/content/4/1/eneuro.0380-16.2017
Fmr1 knockout mice showed increased baseline and auditory-evoked high-frequency ... After all baclofen was not invented or designed for FXS.
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94
Necroptosis, ADAM proteases and intestinal (dys)function
http://amp.turbo.fr/local-searching-02bj5CdjVmcpRWZj5WZpN2cuc3d39yL6MHc0/science/article/pii/S193764482030006X
In the pathologic situation, several studies in mouse models have implicated IEC necroptosis as a ... An IEC-specific knockout of caspase-8 as a negative ...
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http://amp.turbo.fr/local-searching-02bj5CdjVmcpRWZj5WZpN2cuc3d39yL6MHc0/science/article/pii/S193764482030006X
In the pathologic situation, several studies in mouse models have implicated IEC necroptosis as a ... An IEC-specific knockout of caspase-8 as a negative ...
→ Check Latest Keyword Rankings ←
95
Black Friday 2022: the Razer Deathadder V2 Pro Wireless ...
https://game-news24.com/2022/11/22/black-friday-2022-the-razer-deathadder-v2-pro-wireless-mouse-is-for-less-than-80-seconds/
If you buy a console for the best price, you can try the console. It's the brand that invented the concept of gaming mouse. The boomslang 1000 ...
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https://game-news24.com/2022/11/22/black-friday-2022-the-razer-deathadder-v2-pro-wireless-mouse-is-for-less-than-80-seconds/
If you buy a console for the best price, you can try the console. It's the brand that invented the concept of gaming mouse. The boomslang 1000 ...
→ Check Latest Keyword Rankings ←
96
The story of the purple tomato — and why its success is a win ...
https://www.udayavani.com/english-news/the-story-of-the-purple-tomato-and-why-its-success-is-a-win-for-gm-foods
... available to the public was a tomato, invented in the US in 1994. ... lived 30 per cent longer compared to the mice given red tomatoes.
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https://www.udayavani.com/english-news/the-story-of-the-purple-tomato-and-why-its-success-is-a-win-for-gm-foods
... available to the public was a tomato, invented in the US in 1994. ... lived 30 per cent longer compared to the mice given red tomatoes.
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97
How Bad is my Batch ?
https://howbad.info/
Knockout in Round 2 ... NEW : Robert Malone, the inventor of mRNA technology, talks about his vaccine injury ... Tested for efficacy (on 8 mice), not safety.
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https://howbad.info/
Knockout in Round 2 ... NEW : Robert Malone, the inventor of mRNA technology, talks about his vaccine injury ... Tested for efficacy (on 8 mice), not safety.
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