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1 The treatment of depression — searching for new ideas
https://www.frontiersin.org/articles/10.3389/fphar.2022.988648/full
Therapy of depressive disorders is based mainly on drugs discovered in the 1960s and early 1970s. Selective serotonin reuptake inhibitors (SSRIs) ...
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2 Emerging Therapeutic Approaches to Treatment-Resistant ...
https://www.ahdbonline.com/supplements/2684-emerging-therapeutic-approaches-to-treatment-resistant-depression-meeting-unmet-clinical-needs
In the acute treatment phase for more severe depression, patients are treated with antidepressants alone or in combination with pharmacotherapy or somatic ...
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3 Experimental depression treatment is nearly 80% effective in ...
https://med.stanford.edu/news/all-news/2021/10/depression-treatment.html
Experimental depression treatment is nearly 80% effective in controlled study. In a double-blind controlled study, high doses of magnetic brain ...
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4 APA offers new guidance for treating depression
https://www.apa.org/monitor/2019/09/ce-corner-depression
As the initial treatment for major depression in adults age 60 and older, the guideline recommends either group life review treatment or group ...
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5 Depression: Emerging Treatment Directions (Transcript)
https://www.medscape.org/viewarticle/725391_transcript
The goal of this activity is to present recent research on current and emerging therapies for depression and offer context for how these findings fit into our ...
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6 New Treatment Strategies of Depression: Based on ... - Hindawi
https://www.hindawi.com/journals/np/2017/4605971/
In conclusion, drugs that modulate neurotransmission via NMDA receptor and noninvasive brain stimulation may provide new directions of treatment for depression.
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7 Unipolar major depression in adults: Choosing initial treatment
https://www.uptodate.com/contents/unipolar-major-depression-in-adults-choosing-initial-treatment
All topics are updated as new evidence becomes available and our peer review process is complete. Literature review current through: Oct 2022. | ...
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8 Depression: Treatment-Resistant - ICER
https://icer.org/assessment/depression-2011/
A majority of the panel voted that evidence supports the use of transcranial magnetic stimulation, a new, emerging technique for treatment-resistant depression.
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9 Depression (major depressive disorder) - Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/depression/diagnosis-treatment/drc-20356013
VNS stimulates the vagus nerve with electrical impulses. This treatment uses a device implanted in your chest that's connected by a wire to a nerve in your neck ...
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10 CURRENT AND EMERGING THERAPEUTICS FOR ... - ACNP
https://acnp.org/wp-content/uploads/2017/11/CH75_1081-1096.pdf
review of antidepressant treatments. (See refs. 1 and 2 for recent reviews.) ... the treatment of depression in children and adolescents is provided.
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11 Complementary therapies for clinical depression - BMJ Open
https://bmjopen.bmj.com/content/9/8/e028527
A moderate-quality Cochrane review found two RCTs investigating the effectiveness and safety of tryptophan supplementation on depression severity.158 Pooling ...
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12 Promising Strategies for Treatment-Resistant Depression
https://www.psychiatrictimes.com/view/promising-strategies-for-treatment-resistant-depression
Significant improvement in depressive symptoms was noted within 24 hours of brexanolone infusion, which is administered as a 60-hour IV infusion ...
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13 Emerging Treatments for Major Depressive Disorder (MDD)
https://pro.psycom.net/assessment-diagnosis-adherence/depression/apa-major-depression-treatment-and-emerging-rapidly-acting-antidepressants
› depression › apa-major-depres...
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14 Whole Body Cryotherapy and Hyperbaric Oxygen Treatment
https://www.mdpi.com/1424-8247/14/6/595
New methods that may fall into the scope of multi-module depression treatment as an augmentation of depression treatment are whole body cryotherapy (WBC) and ...
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15 Treatment - Clinical depression - NHS
https://www.nhs.uk/mental-health/conditions/clinical-depression/treatment/
Treatment for depression usually involves a combination of self-help, talking therapies and medicines. The treatment recommended will be based on the type ...
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16 Esketamine: new hope for the treatment of treatment-resistant ...
https://journals.sagepub.com/doi/full/10.1177/2042098620937899
Change in MADRS score from baseline to 4 h after the initial dose. ... Remission of depressive symptoms (MADRS score ⩽12). Significantly greater improvement in ...
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17 New Treatment for Clinical Depression Auvelity Approved by ...
https://www.everydayhealth.com/depression/fda-approves-new-medication-for-clinical-depression/
Auvelity is a new, fast-acting drug used to treat major depressive disorder or clinical depression. It is the first pill in more than 60 ...
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18 Depression Treatment & Management - Medscape Reference
https://emedicine.medscape.com/article/286759-treatment
Medication alone (see Medication) and brief psychotherapy (e.g., cognitive-behavioral therapy, interpersonal therapy) alone can relieve ...
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19 Treatment outcomes for depression: challenges and ...
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(20)30036-5/fulltext
Effective treatments are available: antidepressant medication and talking therapies are included in most guidelines as first-line treatments.
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20 New Directions in the Treatment of Atypical Depression
https://www.psychiatrist.com/wp-content/uploads/2021/02/24926_introduction-directions-treatment-atypical-depression.pdf
New Directions in the Treatment of Atypical Depression. Michael E. Thase, M.D.. From the Department of Psychiatry, University of Pittsburgh.
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21 New Treatment for Depression Causes Remission in Most ...
https://www.additudemag.com/depression-treatment-snt-news/
The new treatment is called Stanford neuromodulation therapy (SNT), an intermittent theta-burst stimulation (iTBS) that delivers magnetic pulses ...
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22 Neuroscientific Advances Supporting New Treatments for ...
https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.20220445
The first paper assesses the efficacy of a digital intervention for treating cognitive deficits in patients with major depression, and the ...
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23 Depression Treatment - HelpGuide.org
https://www.helpguide.org/articles/depression/depression-treatment.htm
Not only does exercise boost serotonin, endorphins, and other feel-good brain chemicals, it triggers the growth of new brain cells and connections, just like ...
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24 Emerging therapies for treatment resistant depression
https://meridian.allenpress.com/mhc/article/4/5/226/37131/Emerging-therapies-for-treatment-resistant
Current treatment with standard antidepressants, which are serotonin or norepinephrine based, psychotherapy or electro-convulsive therapy (ECT), ...
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25 Can Depression Be Cured? What the Latest Research Says
https://www.healthline.com/health/can-you-cure-depression
Therapy, medication, and brain stimulation are the primary treatment options for depression. But complementary approaches can be a helpful addition to your ...
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26 Common Treatment Options for Clinical Depression - WebMD
https://www.webmd.com/depression/depression-treatment-options
Your treatment plan for depression will depend on what type you have and how severe it is. Some people get psychotherapy.
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27 Full article: Emerging treatments for major depression
https://www.tandfonline.com/doi/full/10.1586/14737175.7.2.203
While for the most part they have proven effective for the amelioration of depressive symptoms, they are associated with significant ...
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28 Immune targets for therapeutic development in depression
https://www.nature.com/articles/s41573-021-00368-1
Patients with MDD are heterogeneous with respect to symptoms, treatment responses and biological correlates. Defining a narrower patient group ...
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29 New Somatic Treatments for Child and Adolescent Depression
https://link.springer.com/article/10.1007/s40501-019-00194-8
This review focuses on current (past 3 years, including published results and ongoing studies) research on somatic treatments for adolescent ...
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30 How Ketamine Drug Helps with Depression - Yale Medicine
https://www.yalemedicine.org/news/ketamine-depression
In 2019. the FDA approved the first new medication for major depression in decades. The drug is a nasal spray called esketamine, derived from ketamine—an ...
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31 SAINT: Hope for new treatment of depression - CBS News
https://www.cbsnews.com/news/saint-treatment-for-depression/
A new experimental treatment using a fast-acting approach with targeted magnetic stimulation of the brain, called Stanford Accelerated ...
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32 Depression Clinical & Research Program
https://www.massgeneral.org/psychiatry/treatments-and-services/depression-clinical-and-research-program
The program conducts research with a focus on testing new antidepressant treatments and developing new tools to understand the biological changes that occur in ...
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33 The global gap in treatment coverage for major depressive ...
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003901
Previous reviews on depression treatment rates have found wide ... A new systematic review was conducted to capture information on treatment ...
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34 [PDF] New Treatment Strategies of Depression - ResearchGate
https://www.researchgate.net/publication/316052848_New_Treatment_Strategies_of_Depression_Based_on_Mechanisms_Related_to_Neuroplasticity
› publication › 316052848_...
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35 New study shows significant gains from computer-based ...
https://news.westernu.ca/2022/05/study-benefits-computer-based-treatment-for-depression/
New study shows significant gains from computer-based depression treatment ... Computer-based cognitive behavioral therapy was found to be ...
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36 Feeling Great: The Revolutionary New Treatment for ...
https://www.amazon.com/Feeling-Great-Revolutionary-Treatment-Depression/dp/168373288X
Feeling Great: The Revolutionary New Treatment for Depression and Anxiety [David D. Burns] on ... Book reviews, interviews, editors' picks, and more.
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37 Predictors, Moderators, and Mediators Associated With ...
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788554
This scoping review describing findings of predictors, moderators, ... Trials for the Treatment of Depressive Disorders in Adolescents.
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38 Depression | Society of Clinical Psychology
https://div12.org/diagnosis/depression/
Psychological Treatments · Acceptance and Commitment Therapy for Depression NEW CONTENT · Behavioral Activation for Depression NEW CONTENT · Cognitive Behavioral ...
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39 FDA approves new nasal spray medication for treatment ...
https://www.fda.gov/news-events/press-announcements/fda-approves-new-nasal-spray-medication-treatment-resistant-depression-available-only-certified
... for the treatment of depression in adults with treatment-resistant ... along with careful review through the FDA's drug approval process ...
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40 Initial treatment choices to achieve sustained response in ...
https://onlinelibrary.wiley.com/doi/full/10.1002/wps.20906
The two mainstays of acute treatment of major depression in adults are antidepressant medications and psychotherapies, each backed by several ...
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41 FDA approves first fast-acting oral drug for clinical depression
https://thehill.com/changing-america/well-being/mental-health/3611104-fda-approves-first-fast-acting-oral-drug-for-clinical-depression/
A newly approved drug from Axsome Therapeutics, Auvelity, can improve symptoms of major depressive disorder (MDD) — also known as clinical ...
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42 Depression Treatment and Management
https://adaa.org/understanding-anxiety/depression/treatment-management
Medication alone and psychotherapy (cognitive-behavioral therapy, interpersonal therapy) alone can relieve depressive symptoms.
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43 An Overview of the Treatments for Depression - Verywell Mind
https://www.verywellmind.com/treatments-for-depression-1065502
Sold under the brand name Spravato, esketamine was FDA approved in March 2019 and is authorized for adults with treatment-resistant depression, ...
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44 Treatment-resistant depression (TRD) - COMPASS Pathways
https://compasspathways.com/our-work/treatment-resistant-depression/
Sometimes depression doesn't get better, even with treatment. 'Treatment-resistant depression' (TRD) is a term used when people with depression do not respond ...
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45 Management of Treatment-Resistant Depression: Challenges ...
https://www.dovepress.com/management-of-treatment-resistant-depression-challenges-and-strategies-peer-reviewed-fulltext-article-NDT
As such, psychotherapy may be employed to address a comorbid diagnosis. A recent Cochrane review examined 6 studies of psychological ...
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46 How Is Depression Treated? Let Me Show You.
https://www.nytimes.com/interactive/2022/09/27/opinion/how-to-treat-depression.html
Off to a new hospital. The hospital where I work doesn't offer esketamine treatment, so the patient seeks it at another hospital.
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47 NICE creates new menu of treatment options for those ...
https://www.nice.org.uk/news/nice-creates-new-menu-of-treatment-options-for-those-suffering-from-depression
Patients with less severe depression could choose from the menu as a first-line treatment option from, for example, cognitive behavioural ...
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48 Innovative treatments: the new frontier for mental health
https://www.drugtargetreview.com/article/101847/innovative-treatments-the-new-frontier-for-mental-health/
Today, rather than using ECT to treat treatment-resistant depression, mental health providers now have the option of leveraging transcranial ...
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49 An experimental depression treatment uses electric currents to ...
https://www.npr.org/sections/health-shots/2022/02/06/1074719132/an-experimental-depression-treatment-uses-electric-currents-to-bring-relief
That's the basic premise of rTMS: Electrical impulses are used to balance out erratic brain activity. As a result, people feel less depressed ...
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50 Researchers breaking away from the central dogma of ...
https://www.statnews.com/2021/08/16/researchers-finally-breaking-away-from-central-dogma-of-depression/
Along with ketamine, other psychedelics, like psilocybin, have emerged as candidates for treatment-resistant depression. A small study published ...
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51 A New Way of Treating Depression, Anxiety, and Trauma
https://www.psychologytoday.com/us/blog/finding-new-home/202111/new-way-treating-depression-anxiety-and-trauma
A new treatment for emotional disorders is called the “unified protocol for ... published in the October 2021 issue of Current Directions in ...
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52 Depression Treatment - Reproductive Health - CDC
https://www.cdc.gov/reproductivehealth/depression/treatments.htm
Carefully review your completed checklist. · Ask several more questions about how you are feeling and acting. · Talk with you about treatment options. · Provide ...
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53 Discovery of new brain pathway could yield new treatments
https://www.medicalnewstoday.com/articles/313302
Researchers have identified a new brain signaling pathway that alleviates depression when blocked; the discovery could open the door to new ...
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54 Esketamine for Treatment-Resistant Depression
https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/esketamine-for-treatment-resistant-depression
There's good news for people with severe treatment-resistant depression: Esketamine is a groundbreaking therapy that can provide relief from major ...
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55 Compelling Research Discovers A Potential Cause of ...
https://www.heysigmund.com/cause-of-depression/
Half of all people with major depression don't find relief from antidepressants. ... Research Finds Possible New Direction for Treatment of Depression.
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56 New molecule shows promise as rapid-acting antidepressant
https://www.fiercebiotech.com/research/drug-acts-brains-dorsal-raphe-nucleus-could-rapidly-treat-depression
Drug that acts on brain's dorsal raphe nucleus could rapidly treat depression ... Selective serotonin reuptake inhibitors, or SSRIs, can take ...
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57 Depression - World Health Organization (WHO)
https://www.who.int/health-topics/depression
Psychological and pharmacological treatments exist for depression. However, in low- and middle-income countries, treatment and support services for ...
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58 Recent advances in the psychopharmacology of major ...
https://www.cambridge.org/core/journals/bjpsych-advances/article/recent-advances-in-the-psychopharmacology-of-major-depressive-disorder/E5D0CCB447659AA928CC4115327A3F5F
When describing new treatment avenues, we examine the evidence base and ... Major depressive disorder (MDD) is a common psychiatric disorder ...
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59 Treatment of Depression in Children and Adolescents
https://effectivehealthcare.ahrq.gov/products/childhood-depression/research
› products › research
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60 Repetitive transcranial magnetic stimulation: an emerging ...
https://www.cmaj.ca/content/188/16/1175
In the sequential treatment approach to major depression, repetitive transcranial magnetic stimulation (rTMS) begins to offer superior efficacy ...
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61 Living Well with Major Depressive Disorder - SAMHSA
https://www.samhsa.gov/serious-mental-illness/major-depression
Set small, achievable goals. Set realistic goals to build confidence and motivation. A goal at the beginning of treatment may be to make your ...
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62 Depression News - ScienceDaily
https://www.sciencedaily.com/news/mind_brain/depression/
Potential New Lead Compounds for the Treatment of Depression and Anxiety Disorders ... (brain inflammation), confusion or seizures, finds a new review of .
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63 Treating Severe Depression with On-Demand Brain Stimulation
https://www.ucsf.edu/news/2021/09/421541/treating-severe-depression-demand-brain-stimulation
UCSF Health physicians have successfully treated a patient with severe depression by tapping into the specific brain circuit involved in ...
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64 Resistant Depression Clinic St Louis | Newsroom
https://www.barnesjewish.org/Newsroom/Publications/Innovate-Physician/Fall-2010/New-Treatment-Resistant-Depression-Clinic
New Treatment-Resistant Depression Clinic ... They carefully review the patient's psychiatric records and oversee patient exams and evaluations.
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65 Screening for Depression in Adults
https://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/depression-in-adults-screening1
Treatment. Effective treatment of depression in adults generally includes antidepressants or specific psychotherapy approaches (eg, CBT or brief ...
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66 New guide for patients with treatment-resistant depression
https://www.vchri.ca/stories/2022/02/02/new-guide-patients-treatment-resistant-depression
The non-invasive rTMS therapy involves applying a series of magnetic pulses to specific areas of the brain to stimulate and change the firing ...
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67 guideline-clinical-investigation-medicinal-products-treatment ...
https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-clinical-investigation-medicinal-products-treatment-depression-revision-2_en.pdf
treatment of Depression' (CPMP/EWP/518/97, Rev. ... there is still a need for new medicinal products with better efficacy (e.g. faster onset ...
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68 Maintenance or Discontinuation of Antidepressants in Primary ...
https://www.nejm.org/doi/full/10.1056/NEJMoa2106356
Patients with depression who are treated in primary care practices may receive antidepressants for prolonged periods.
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69 TMS Therapy offers adults with depression new treatment option
https://lindnercenterofhope.org/wp-content/uploads/2014/06/10Art_TMS.pdf
A new medical treatment that sends magnetic pulses to the brain has been found effective for some people battling major depression. Studies show the treatment ...
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70 New Somatic Treatments for Child and Adolescent ...
https://psychopharmacologyinstitute.com/section/new-somatic-treatments-for-child-and-adolescent-depression-part-1-2578-5017
According to several recent reviews, these are cognitive–behavioral therapy, interpersonal therapy, fluoxetine, and escitalopram. This twin pair ...
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71 A Study of Psilocybin for Major Depressive Disorder (MDD)
https://clinicaltrials.gov/ct2/show/NCT03866174
Depressive Disorder, Major, Drug: Psilocybin Drug: Niacin, Phase 2 ... Psychedelic-Assisted Therapy: Emerging Treatments in Mental Health Disorders.
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72 Diagnosis, Treatment, and Management of Depression
https://www.reliasmedia.com/articles/147339-diagnosis-treatment-and-management-of-depression-the-role-of-the-primary-care-provider
To diagnose depression, both systems require the presence of at least one key symptom: depressed mood or loss of interest/energy. Both specify ...
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73 Treatment Resistant Depression
https://www.ncpsychiatry.org/assets/2016AnnualMeeting/Handouts/2_treatment_resistant_depression-michael_thase.pdf
who showed inadequate response or intolerance to treatment with a ... in patients with major depressive disorder and insufficient response ...
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74 New Hope for Depression | TIME
https://time.com/magazine/us/4876068/august-7th-2017-vol-190-no-6-u-s/
Every week, when Ian Hanley sits down with his therapist, he goes through a list of depression treatments he's been researching online. The best ...
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75 New Analyses Strengthen Efficacy, Safety of Zuranolone for ...
https://www.pharmacytimes.com/view/new-analyses-strengthen-efficacy-safety-of-zuranolone-for-depression
Eleven new analyses on zuranolone, an investigational, oral, once-daily, 14-day treatment in clinical development for adult patients with ...
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76 NHS to give therapy for depression before medication under ...
https://www.theguardian.com/society/2021/nov/23/nhs-to-give-therapy-for-depression-before-medication-under-new-guidelines
This could be followed by offers of seven other treatments including individual CBT, self help, group exercise or group mindfulness or ...
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77 The Deceptive Manifestations of Treatment Resistance in ...
https://www.karger.com/Article/FullText/507227
The Deceptive Manifestations of Treatment Resistance in Depression: A New Look at ... applying cognitive-behavioral strategies to the patient population.
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78 New Treatment Approved for Depression - Sharp HealthCare
https://www.sharp.com/health-news/new-treatment-approved-for-depression.cfm
› health-news › new-treatment-a...
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79 New Treatment Options for Depression: A Primer for Internists ...
https://www.semanticscholar.org/paper/New-Treatment-Options-for-Depression%3A-A-Primer-for-Byun-Chaliki/0bc4dbd502251fe6854f8a07affa039d9544bf7b
This paper reviews commonly used options for treatment after an inadequate initial antidepressant response and suggests that it is reasonable to take one or ...
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80 New treatment shows promising improvements for women ...
https://tracs.unc.edu/index.php/news-articles/1130-new-treatment-shows-promising-improvements-for-women-with-postpartum-depression
The drug, ZULRESSO (brexanolone), showed rapid reduction in depressive symptoms during clinical trials, making it the first and only treatment ...
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81 Opening Up About My Struggle With Recurring Depression
https://www.healthaffairs.org/doi/10.1377/hlthaff.2021.00894
When applying for security clearance for the White House job, the questionnaire asked whether I had been hospitalized for a psychiatric ...
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82 Effective management of depression in primary care: a review ...
https://bjgpopen.org/content/1/2/bjgpopen17X101025
Psychological therapies should usually be first choice for most patients with mild-to-moderate depression in primary care, and drug treatment should only be ...
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83 Nonpharmacologic Treatments for Treatment-Resistant ...
https://www.hca.wa.gov/assets/program/TRD_final_report_022114[1].pdf
APPENDIX I. Definitions of Treatment-Resistant Depression (TRD) . ... psychotherapy as a new treatment in response to treatment failure), ...
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84 Combined drug and psychological therapies may be most ...
https://evidence.nihr.ac.uk/alert/combined-drug-and-psychological-therapies-may-be-most-effective-for-depression/
The most effective treatment for adults with moderate depression is likely to be a combination of antidepressant drugs and psychological ...
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85 Depression and Depressive Disorders - Life Extension
https://www.lifeextension.com/protocols/emotional-health/depression
Integrative therapies such as omega-3 polyunsaturated fatty acids, vitamin D, probiotics, zinc, and saffron extract, along with healthy eating habits, regular ...
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86 Analysis: Depression is probably not caused by a chemical ...
https://www.ucl.ac.uk/news/2022/jul/analysis-depression-probably-not-caused-chemical-imbalance-brain-new-study
However, our latest research review shows that the evidence does not ... Two new treatment regimens for multidrug-resistant tuberculosis are ...
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87 Sage Therapeutics and Biogen Announce that the Phase 3 ...
https://investors.biogen.com/news-releases/news-release-details/sage-therapeutics-and-biogen-announce-phase-3-skylark-study
Postpartum depression is one of the most common medical ... In women in both treatment groups who experienced treatment emergent adverse ...
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88 New Mechanisms Emerging for the Treatment of Depression
https://www.hmpgloballearningnetwork.com/site/pcn/article/new-mechanisms-emerging-treatment-depression
A number of innovative mechanisms of action for treating depression will likely debut over the next 3 years, following a decades-long ...
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89 Transcranial Magnetic Stimulation: A New Approach to ...
https://brainstimcenters.com/transcranial-magnetic-stimulation-a-new-approach-to-treating-depression/
Traditionally, depression is treated using pharmapsychology, psychotherapy, and electroconvulsive therapy (ECT), with mixed success. Many find ...
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90 A randomised controlled trial of dietary improvement for adults ...
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-017-0791-y
Depression symptomatology was the primary endpoint, ... Australia and New Zealand Clinical Trials Register (ANZCTR): ACTRN12612000251820 .
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91 Guidelines for Adolescent Depression in Primary Care (GLAD ...
https://publications.aap.org/pediatrics/article/141/3/e20174082/37654/Guidelines-for-Adolescent-Depression-in-Primary
Numerous meta-analyses and reviews have been conducted on CBT in the treatment of adolescent depression and showed improved outcomes for ...
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92 A personalised alternative to antidepressants is on the way
https://psyche.co/ideas/a-personalised-alternative-to-antidepressants-is-on-the-way
Unbeknown to most of the public, there's a new therapy, now established in clinical practice, called transcranial magnetic stimulation (TMS) ...
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93 Largest trial to date shows that psilocybin reduces depression ...
https://www.kcl.ac.uk/news/largest-trial-to-date-shows-that-psilocybin-reduces-depression-symptoms
Psilocybin therapy may be a new paradigm of treatment, ... went on to say: "These findings are a positive step in the right direction.
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94 What Depression Treatment Will Look Like in the Near Future
https://www.behavioralhealthflorida.com/blog/what-depression-treatment-will-look-like-in-the-near-future/
While current treatment options work for many of these patients, others continue to live with debilitating symptoms. Emerging trends in mental ...
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