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Google Keyword Rankings for : chemical chaperone clinical
1
The therapeutic potential of chemical chaperones in ... - NCBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189890/
It may be that once clinical symptoms appear, the level of protein aggregation and accumulation is too high to be affected by prevention of further misfolding.
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189890/
It may be that once clinical symptoms appear, the level of protein aggregation and accumulation is too high to be affected by prevention of further misfolding.
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2
Chemical Chaperone - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/chemical-chaperone
Sodium phenylbutyrate (PBA) and tauroursodeoxycholic acid (TUDCA) are two small chemical chaperones that are in clinical trials for neurodegenerative diseases ...
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https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/chemical-chaperone
Sodium phenylbutyrate (PBA) and tauroursodeoxycholic acid (TUDCA) are two small chemical chaperones that are in clinical trials for neurodegenerative diseases ...
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3
Cell-based HTS identifies a chemical chaperone for ... - eLife
https://elifesciences.org/articles/43302
Here, we identified 2-phenylimidazo[2,1-b]benzothiazole derivatives (IBTs) as chemical chaperones in a cell-based high-throughput screen.
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https://elifesciences.org/articles/43302
Here, we identified 2-phenylimidazo[2,1-b]benzothiazole derivatives (IBTs) as chemical chaperones in a cell-based high-throughput screen.
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4
The Chemical Chaperone Proline Relieves ... - ASM Journals
https://journals.asm.org/doi/abs/10.1128/jb.186.23.8149-8152.2004
In vitro, like other “chemical chaperones,” and like the DnaK chaperone, proline protects citrate synthase against thermodenaturation and stimulates citrate ...
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https://journals.asm.org/doi/abs/10.1128/jb.186.23.8149-8152.2004
In vitro, like other “chemical chaperones,” and like the DnaK chaperone, proline protects citrate synthase against thermodenaturation and stimulates citrate ...
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5
Q&A: What are pharmacological chaperones and why are they ...
https://jbiol.biomedcentral.com/articles/10.1186/jbiol186
So a pharmacological chaperone is a chemical chaperone? ... Has there been any clinical success with pharmacological chaperones? There has.
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https://jbiol.biomedcentral.com/articles/10.1186/jbiol186
So a pharmacological chaperone is a chemical chaperone? ... Has there been any clinical success with pharmacological chaperones? There has.
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6
Chemical Chaperone Therapy: Clinical Effect in Murine GM1 ...
https://onlinelibrary.wiley.com/doi/pdf/10.1002/ana.21284
neurological scoring system was used for clinical assessment. ... chemical chaperone therapy of human GM1-gangliosidosis.
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https://onlinelibrary.wiley.com/doi/pdf/10.1002/ana.21284
neurological scoring system was used for clinical assessment. ... chemical chaperone therapy of human GM1-gangliosidosis.
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7
What are Chaperone Proteins? - News Medical
https://www.news-medical.net/life-sciences/What-are-Chaperone-Proteins.aspx
To relieve this ER stress, small molecules called chemical chaperones are used that promote proper protein folding. The positive influences of chemical ...
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https://www.news-medical.net/life-sciences/What-are-Chaperone-Proteins.aspx
To relieve this ER stress, small molecules called chemical chaperones are used that promote proper protein folding. The positive influences of chemical ...
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8
Chemical Chaperones Modulate the Formation of Metabolite ...
https://www.mdpi.com/1422-0067/22/17/9172/htm
... agents are available for clinical use. Chemical chaperones are known to inhibit protein and peptide amyloid formation and stabilize misfolded enzymes.
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https://www.mdpi.com/1422-0067/22/17/9172/htm
... agents are available for clinical use. Chemical chaperones are known to inhibit protein and peptide amyloid formation and stabilize misfolded enzymes.
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9
Obesity-Linked Variants of Melanocortin-4 Receptor Are ...
https://academic.oup.com/mend/article/24/9/1805/2706163
Incubation with a chemical chaperone, PBA, has been shown to improve ... Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.
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https://academic.oup.com/mend/article/24/9/1805/2706163
Incubation with a chemical chaperone, PBA, has been shown to improve ... Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.
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10
A Bicyclic 1-Deoxygalactonojirimycin Derivative as a Novel ...
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)30621-9
Pharmacological chaperone (PC) therapy has been developed as a possible approach ... Chemical chaperone therapy: clinical effect in murine ...
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https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)30621-9
Pharmacological chaperone (PC) therapy has been developed as a possible approach ... Chemical chaperone therapy: clinical effect in murine ...
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11
Chemical Modulator of Chaperone-mediated Autophagy in ...
https://www.michaeljfox.org/grant/chemical-modulator-chaperone-mediated-autophagy-parkinsons-disease
Chemical Modulator of Chaperone-mediated Autophagy in Parkinson's Disease ... be to generate a drug that could be tested in clinical trials for PD patients.
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https://www.michaeljfox.org/grant/chemical-modulator-chaperone-mediated-autophagy-parkinsons-disease
Chemical Modulator of Chaperone-mediated Autophagy in Parkinson's Disease ... be to generate a drug that could be tested in clinical trials for PD patients.
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12
Chemical chaperones increase the cellular activity of N370S β ...
https://www.pnas.org/doi/10.1073/pnas.192582899
Accumulation of the substrate (glucosylceramide) leads to hepatomegaly, splenomegaly, bone crisis, anemia, and CNS involvement. Clinically, Gaucher disease is ...
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https://www.pnas.org/doi/10.1073/pnas.192582899
Accumulation of the substrate (glucosylceramide) leads to hepatomegaly, splenomegaly, bone crisis, anemia, and CNS involvement. Clinically, Gaucher disease is ...
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13
Reduction of ER stress via a chemical chaperone prevents ...
https://www.jci.org/articles/view/82799
Viewing as Journal of Clinical Investigation. ... Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary ...
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https://www.jci.org/articles/view/82799
Viewing as Journal of Clinical Investigation. ... Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary ...
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14
Abstracts - American Epilepsy Society
https://cms.aesnet.org/abstractslisting/chemical-chaperone-therapy-for-developmental-and-epileptic-encephalopathies-(dees)-%E2%80%93-identifying-candidates-via-literature-review
Chemical Chaperone Therapy for Developmental and Epileptic ... in animal models and is currently under evaluation in a clinical trial.
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https://cms.aesnet.org/abstractslisting/chemical-chaperone-therapy-for-developmental-and-epileptic-encephalopathies-(dees)-%E2%80%93-identifying-candidates-via-literature-review
Chemical Chaperone Therapy for Developmental and Epileptic ... in animal models and is currently under evaluation in a clinical trial.
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15
Chemical and pharmacological chaperones as new ...
https://www.cambridge.org/core/journals/expert-reviews-in-molecular-medicine/article/chemical-and-pharmacological-chaperones-as-new-therapeutic-agents/7CB59A4067DF963D6F85514A9017BD8B
It might not be practical to use chemical chaperones in clinical studies. The body could metabolise osmolytes such as glycerol, and the high concentrations ...
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https://www.cambridge.org/core/journals/expert-reviews-in-molecular-medicine/article/chemical-and-pharmacological-chaperones-as-new-therapeutic-agents/7CB59A4067DF963D6F85514A9017BD8B
It might not be practical to use chemical chaperones in clinical studies. The body could metabolise osmolytes such as glycerol, and the high concentrations ...
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16
Medline ® Abstract for Reference 94 of 'Fabry disease
https://www.uptodate.com/contents/fabry-disease-clinical-features-and-diagnosis/abstract/94
Medline ® Abstract for Reference 94 of 'Fabry disease: Clinical features and ... Small molecule chemical chaperones will be therapeutically useful for ...
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https://www.uptodate.com/contents/fabry-disease-clinical-features-and-diagnosis/abstract/94
Medline ® Abstract for Reference 94 of 'Fabry disease: Clinical features and ... Small molecule chemical chaperones will be therapeutically useful for ...
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17
Chemical Chaperones: Mechanisms of Action and Potential Use
https://link.springer.com/chapter/10.1007/3-540-29717-0_16
The small molecules were named chemical chaperones and it is thought that they ... phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial.
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https://link.springer.com/chapter/10.1007/3-540-29717-0_16
The small molecules were named chemical chaperones and it is thought that they ... phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial.
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18
Identification of a chemical chaperone for preventing protein ...
https://www.researchgate.net/publication/339992577_Identification_of_a_chemical_chaperone_for_preventing_protein_aggregation_and_proteotoxicity_under_endoplasmic_reticulum_stress
Request PDF | Identification of a chemical chaperone for preventing ... of ER proteostatis and subsequent clinical pathologies including ...
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https://www.researchgate.net/publication/339992577_Identification_of_a_chemical_chaperone_for_preventing_protein_aggregation_and_proteotoxicity_under_endoplasmic_reticulum_stress
Request PDF | Identification of a chemical chaperone for preventing ... of ER proteostatis and subsequent clinical pathologies including ...
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19
Chemical Chaperone Therapies for STXBP1
https://www.stxbp1disorders.org/blog/chemical-chaperones-for-stxbp1
For the chemical chaperones identified by Jacqueline Burre's lab, 4-phenylbutyrate was selected to test in a clinical trial at Weill Cornell ...
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https://www.stxbp1disorders.org/blog/chemical-chaperones-for-stxbp1
For the chemical chaperones identified by Jacqueline Burre's lab, 4-phenylbutyrate was selected to test in a clinical trial at Weill Cornell ...
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20
Candidate molecules for chemical chaperone therapy of GM1 ...
https://www.semanticscholar.org/paper/Candidate-molecules-for-chemical-chaperone-therapy-Higaki-Ninomiya/7e9e975316ad6c695eea9b6aa5fff5d9e96272a3
Chemical or pharmacological chaperones are small molecules that bind to and ... A Phase I/II clinical trial for GM1 children is ongoing to ...
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https://www.semanticscholar.org/paper/Candidate-molecules-for-chemical-chaperone-therapy-Higaki-Ninomiya/7e9e975316ad6c695eea9b6aa5fff5d9e96272a3
Chemical or pharmacological chaperones are small molecules that bind to and ... A Phase I/II clinical trial for GM1 children is ongoing to ...
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21
A chemical chaperone improves muscle function in ... - ryr1.org
https://ryr1.org/medical-literature/a-chemical-chaperone-improves-muscle-function-in-mice-with-a-ryr1-mutation
A chemical chaperone improves muscle function in nice with a RyR1 mutation. Medical Literature. March 24, 2017. A chemical chaperone improves muscle ...
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https://ryr1.org/medical-literature/a-chemical-chaperone-improves-muscle-function-in-mice-with-a-ryr1-mutation
A chemical chaperone improves muscle function in nice with a RyR1 mutation. Medical Literature. March 24, 2017. A chemical chaperone improves muscle ...
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22
Tuning protein folding in lysosomal storage diseases
https://pubs.rsc.org/en/content/articlehtml/2018/sc/c7sc04712f
Chemical and pharmacological chaperones are small molecules capable ... to prevent clinical manifestations of the disease, chaperone-based ...
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https://pubs.rsc.org/en/content/articlehtml/2018/sc/c7sc04712f
Chemical and pharmacological chaperones are small molecules capable ... to prevent clinical manifestations of the disease, chaperone-based ...
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23
Effect of a chemical chaperone, tauroursodeoxycholic acid, on ...
https://journals.physiology.org/doi/full/10.1152/ajplung.00396.2015
Among the ER stress inhibitor chaperones, tauroursodeoxycholic acid (TUDCA) is clinically used in the treatment of cholelithiasis and cholestatic liver ...
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https://journals.physiology.org/doi/full/10.1152/ajplung.00396.2015
Among the ER stress inhibitor chaperones, tauroursodeoxycholic acid (TUDCA) is clinically used in the treatment of cholelithiasis and cholestatic liver ...
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24
Effects of the Chemical Chaperone Sodium Phenylbutyrate ...
https://professional.diabetes.org/abstract/effects-chemical-chaperone-sodium-phenylbutyrate-buphenyl-glucose-stimulated-insulin
Effects of the Chemical Chaperone Sodium Phenylbutyrate (Buphenyl) on Glucose-Stimulated Insulin Secretion and Insulin Sensitivity in Obese and Overweight ...
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https://professional.diabetes.org/abstract/effects-chemical-chaperone-sodium-phenylbutyrate-buphenyl-glucose-stimulated-insulin
Effects of the Chemical Chaperone Sodium Phenylbutyrate (Buphenyl) on Glucose-Stimulated Insulin Secretion and Insulin Sensitivity in Obese and Overweight ...
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25
Chemical Chaperones Reduce ER Stress and ... - Science
https://www.science.org/doi/abs/10.1126/science.1128294
by U Özcan · 2006 · Cited by 2624 —
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https://www.science.org/doi/abs/10.1126/science.1128294
by U Özcan · 2006 · Cited by 2624 —
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26
Cell-based HTS identifies a chemical chaperone for ...
https://www.readcube.com/articles/10.7554/eLife.43302
and clinical pathologies. Chemical chaperones have recently emerged as a potential therapeutic approach for ER stress-related diseases.
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https://www.readcube.com/articles/10.7554/eLife.43302
and clinical pathologies. Chemical chaperones have recently emerged as a potential therapeutic approach for ER stress-related diseases.
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27
Chaperone therapy for neuronopathic lysosomal diseases ...
https://go.gale.com/ps/i.do?id=GALE%7CA403450174&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=1177391X&p=HRCA&sw=w
Enzyme replacement therapy is currently in use for clinical practice for Gaucher disease, ... Therapeutic Approach to Brain Pathology by Chemical Chaperones.
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https://go.gale.com/ps/i.do?id=GALE%7CA403450174&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=1177391X&p=HRCA&sw=w
Enzyme replacement therapy is currently in use for clinical practice for Gaucher disease, ... Therapeutic Approach to Brain Pathology by Chemical Chaperones.
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28
What Is the Potential for Lumacaftor as a Chemical Chaperone ...
https://www.frontiersin.org/articles/10.3389/fcvm.2022.801927/full
Therefore, exogenous chemical chaperones generating a pharmacological ... by the Food and Drug Administration (FDA) for the clinical treatment of CF, ...
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https://www.frontiersin.org/articles/10.3389/fcvm.2022.801927/full
Therefore, exogenous chemical chaperones generating a pharmacological ... by the Food and Drug Administration (FDA) for the clinical treatment of CF, ...
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29
A Chemical Chaperone Rescues Glaucoma By Reducing ER ...
https://iovs.arvojournals.org/article.aspx?articleid=2358368
by GS Zode · 2011 —
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https://iovs.arvojournals.org/article.aspx?articleid=2358368
by GS Zode · 2011 —
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30
Potential Treatments for Protein Conformational Diseases
https://journals.sagepub.com/doi/10.4137/PMC.S212
Chemical Chaperone and Inhibitor Discovery: Potential Treatments for Protein ... Currently, quinacrine has been clinically approved and clinical trials are ...
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https://journals.sagepub.com/doi/10.4137/PMC.S212
Chemical Chaperone and Inhibitor Discovery: Potential Treatments for Protein ... Currently, quinacrine has been clinically approved and clinical trials are ...
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31
Treating lysosomal storage diseases with pharmacological ...
https://www.embopress.org/doi/10.1002/emmm.200900036
After proof-of-concept studies, PCT is now being translated into clinical ... Chemical chaperone therapy: clinical effect in murine GM1-gangliosidosis.
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https://www.embopress.org/doi/10.1002/emmm.200900036
After proof-of-concept studies, PCT is now being translated into clinical ... Chemical chaperone therapy: clinical effect in murine GM1-gangliosidosis.
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32
Chemical Endoplasmic Reticulum Chaperone Alleviates ...
https://www.ahajournals.org/doi/abs/10.1161/circresaha.115.307604
Objective: We evaluated the role of ER stress in doxorubicin-induced cardiotoxicity and examined whether the chemical ER chaperone could prevent ...
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https://www.ahajournals.org/doi/abs/10.1161/circresaha.115.307604
Objective: We evaluated the role of ER stress in doxorubicin-induced cardiotoxicity and examined whether the chemical ER chaperone could prevent ...
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33
Medical Science Monitor - Article abstract #898623
https://medscimonit.com/abstract/index/idArt/898623
Chemical Chaperone 4-Phenylbutyric Acid Reduces Cardiac Ischemia/Reperfusion Injury by Alleviating Endoplasmic Reticulum Stress and Oxidative Stress.
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https://medscimonit.com/abstract/index/idArt/898623
Chemical Chaperone 4-Phenylbutyric Acid Reduces Cardiac Ischemia/Reperfusion Injury by Alleviating Endoplasmic Reticulum Stress and Oxidative Stress.
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34
Chemical Chaperone for MCAD Deficiency | Children's Hospital
https://www.chp.edu/research/areas/genetics/projects/mohsen/chemical-chaperone
A clinical study has started to evaluate the effect of the drug Buphenol on MCAD K304E patients. The second approach was to identify ligands that can bind to ...
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https://www.chp.edu/research/areas/genetics/projects/mohsen/chemical-chaperone
A clinical study has started to evaluate the effect of the drug Buphenol on MCAD K304E patients. The second approach was to identify ligands that can bind to ...
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35
Chemical Chaperones | Encyclopedia MDPI
https://encyclopedia.pub/entry/14183
Unlike pharmacological chaperones, chemical chaperones are small molecules that do not bind a single misfolded protein-ligand but rather function in a non- ...
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https://encyclopedia.pub/entry/14183
Unlike pharmacological chaperones, chemical chaperones are small molecules that do not bind a single misfolded protein-ligand but rather function in a non- ...
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36
Emerging novel concept of chaperone therapies for protein ...
https://www.jstage.jst.go.jp/article/pjab/90/5/90_145/_html/-char/en
Correlation between residual β-galactosidase activity and clinical onset. ... Galactose was reported to be a potential chemical chaperone in some ...
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https://www.jstage.jst.go.jp/article/pjab/90/5/90_145/_html/-char/en
Correlation between residual β-galactosidase activity and clinical onset. ... Galactose was reported to be a potential chemical chaperone in some ...
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37
The potential action of galactose as a "chemical chaperone"
https://read.qxmd.com/read/18571950/the-potential-action-of-galactose-as-a-chemical-chaperone-increase-of-beta-galactosidase-activity-in-fibroblasts-from-an-adult-gm1-gangliosidosis-patient
Protein misfolding in lysosomal defects may have the potential to be corrected by chemical chaperones: in vitro and clinical approaches are being ...
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https://read.qxmd.com/read/18571950/the-potential-action-of-galactose-as-a-chemical-chaperone-increase-of-beta-galactosidase-activity-in-fibroblasts-from-an-adult-gm1-gangliosidosis-patient
Protein misfolding in lysosomal defects may have the potential to be corrected by chemical chaperones: in vitro and clinical approaches are being ...
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38
The therapeutic potential of chemical chaperones in protein ...
https://www.tandfonline.com/doi/abs/10.4161/pri.28938?tab=permissions&scroll=top
› ... › Volume 8, Issue 2
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https://www.tandfonline.com/doi/abs/10.4161/pri.28938?tab=permissions&scroll=top
› ... › Volume 8, Issue 2
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39
A Single Ascending and Repeated Dose Study of Oral ZF874 ...
https://clinicaltrials.gov/ct2/show/NCT04443192
ZF874 is a novel chemical chaperone that is specifically designed to rescue the folding of the Z variant of alpha-1-antitrypsin (A1AT).
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https://clinicaltrials.gov/ct2/show/NCT04443192
ZF874 is a novel chemical chaperone that is specifically designed to rescue the folding of the Z variant of alpha-1-antitrypsin (A1AT).
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40
Evidence that Chemical Chaperone 4-Phenylbutyric Acid ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133012
The chemical chaperone, 4-Phenylbutyric acid (4-PBA) is a FDA ... out the pharmacokinetics of 4-PBA in obese patients in clinical dosages.
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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133012
The chemical chaperone, 4-Phenylbutyric acid (4-PBA) is a FDA ... out the pharmacokinetics of 4-PBA in obese patients in clinical dosages.
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41
Cell-based HTS identifies a chemical chaperone ... - Agris (FAO)
https://agris.fao.org/agris-search/search.do?recordID=DJ20210322662
Cell-based HTS identifies a chemical chaperone for preventing ER protein ... Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan; ...
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https://agris.fao.org/agris-search/search.do?recordID=DJ20210322662
Cell-based HTS identifies a chemical chaperone for preventing ER protein ... Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan; ...
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42
Protein–Protein Interactions in the Molecular Chaperone ...
https://pubs.acs.org/doi/abs/10.1021/acs.accounts.8b00036
Indeed, chemical biology has played a particularly important role in this effort, as molecules that either promote or inhibit specific PPIs have ...
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https://pubs.acs.org/doi/abs/10.1021/acs.accounts.8b00036
Indeed, chemical biology has played a particularly important role in this effort, as molecules that either promote or inhibit specific PPIs have ...
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43
Proteostasis: Bad news and good news from the endoplasmic ...
https://smw.ch/article/doi/smw.2014.14001
Keywords: Endoplasmic reticulum (ER), Chemical chaperones, ... Although some of these drugs have made it to clinical trials and beyond, ...
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https://smw.ch/article/doi/smw.2014.14001
Keywords: Endoplasmic reticulum (ER), Chemical chaperones, ... Although some of these drugs have made it to clinical trials and beyond, ...
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44
“Chaperone” Compounds Offer New Approach to Alzheimer's ...
https://www.cuimc.columbia.edu/news/chaperone-compounds-offer-new-approach-alzheimers-treatment
Image credit: Nature Chemical Biology and lab of Scott A. Small, MD/Columbia University Medical Center. NEW YORK, NY (April 20, ...
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https://www.cuimc.columbia.edu/news/chaperone-compounds-offer-new-approach-alzheimers-treatment
Image credit: Nature Chemical Biology and lab of Scott A. Small, MD/Columbia University Medical Center. NEW YORK, NY (April 20, ...
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45
Logical Design of Medical Chaperone for Prion Diseases
https://www.eurekaselect.com/node/115691/4
Current Topics in Medicinal Chemistry. Editor-in-Chief ... Logical Design of Medical Chaperone for Prion Diseases. Author(s): Kazuo Kuwata.
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https://www.eurekaselect.com/node/115691/4
Current Topics in Medicinal Chemistry. Editor-in-Chief ... Logical Design of Medical Chaperone for Prion Diseases. Author(s): Kazuo Kuwata.
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46
The Chemical Chaperone, PBA, Reduces ER Stress and ...
https://www.kireports.org/article/S2468-0249(17)30058-X/fulltext
This study examined the effects of chemical chaperone treatment ... Table 1Clinical features in males with X-linked Alport syndrome and ...
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https://www.kireports.org/article/S2468-0249(17)30058-X/fulltext
This study examined the effects of chemical chaperone treatment ... Table 1Clinical features in males with X-linked Alport syndrome and ...
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47
Chemical chaperone TUDCA prevents apoptosis and ...
https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=6463&context=open_access_pubs
The Walter and Eliza Hall Institute of Medical Research ... that administration of the chemical chaperone TUDCA helped to maintain ...
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https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=6463&context=open_access_pubs
The Walter and Eliza Hall Institute of Medical Research ... that administration of the chemical chaperone TUDCA helped to maintain ...
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48
Cracking the chaperone code is seen as key to better cancer ...
https://www.upstate.edu/whatsup/2021/080421-cracking-the-chaperone-code-seen-as-key-to-better-cancer-drugs.php
These drugs are currently being evaluated in phase III clinical trials ... The Journal of Biological Chemistry recently published an invited ...
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https://www.upstate.edu/whatsup/2021/080421-cracking-the-chaperone-code-seen-as-key-to-better-cancer-drugs.php
These drugs are currently being evaluated in phase III clinical trials ... The Journal of Biological Chemistry recently published an invited ...
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49
The Chemical Chaperone 4-Phenylbutyrate Increases ...
https://ashpublications.org/blood/article/132/Supplement%201/3777/264971/The-Chemical-Chaperone-4-Phenylbutyrate-Increases
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https://ashpublications.org/blood/article/132/Supplement%201/3777/264971/The-Chemical-Chaperone-4-Phenylbutyrate-Increases
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50
Chaperone-assisted protein folding - Lasker Foundation
https://laskerfoundation.org/winners/chaperone-assisted-protein-folding/
2011 Albert Lasker Basic Medical Research Award ... Anfinsen, who shared the 1972 Nobel Prize in Chemistry for his discovery, ...
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https://laskerfoundation.org/winners/chaperone-assisted-protein-folding/
2011 Albert Lasker Basic Medical Research Award ... Anfinsen, who shared the 1972 Nobel Prize in Chemistry for his discovery, ...
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51
Molecular Basis of Chemical Chaperone Effects of N-octyl-β ...
https://www.longdom.org/open-access/molecular-basis-of-chemical-chaperone-effects-of-noctylbetavalienamine-on-human-betaglucosidase-in-lowneutral-ph-conditi-32034.html
Molecular Basis of Chemical Chaperone Effects of N-octyl-β-valienamine on Human ... (2007) Chemical chaperone therapy: clinical effect in murine ...
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https://www.longdom.org/open-access/molecular-basis-of-chemical-chaperone-effects-of-noctylbetavalienamine-on-human-betaglucosidase-in-lowneutral-ph-conditi-32034.html
Molecular Basis of Chemical Chaperone Effects of N-octyl-β-valienamine on Human ... (2007) Chemical chaperone therapy: clinical effect in murine ...
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52
Chemical Chaperone 4-Phenyl Butyric Acid (4-PBA) Reduces ...
https://www.jcehepatology.com/article/S0973-6883(17)30236-0/fulltext
Chemical Chaperone 4-Phenyl Butyric Acid (4-PBA) Reduces Hepatocellular Lipid Accumulation and Lipotoxicity Through Induction of Autophagy · Background and Aim: ...
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https://www.jcehepatology.com/article/S0973-6883(17)30236-0/fulltext
Chemical Chaperone 4-Phenyl Butyric Acid (4-PBA) Reduces Hepatocellular Lipid Accumulation and Lipotoxicity Through Induction of Autophagy · Background and Aim: ...
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53
Covalent inhibition of endoplasmic reticulum chaperone ...
https://www.biorxiv.org/content/10.1101/2021.08.20.457085v1.full
Celastrol forms covalent conjugate with ER chaperone GRP78. (A) Click chemistry biotinylation and affinity isolation of celastrol-bound proteins ...
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https://www.biorxiv.org/content/10.1101/2021.08.20.457085v1.full
Celastrol forms covalent conjugate with ER chaperone GRP78. (A) Click chemistry biotinylation and affinity isolation of celastrol-bound proteins ...
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54
Decrypting the chaperone code - Journal of Biological Chemistry
https://www.jbc.org/article/S0021-9258(21)00061-2/fulltext
Therefore, targeting Hsp90 in preclinical studies and clinical trials in these diseases has been actively pursued (.
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https://www.jbc.org/article/S0021-9258(21)00061-2/fulltext
Therefore, targeting Hsp90 in preclinical studies and clinical trials in these diseases has been actively pursued (.
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55
144365.pdf - University of Glasgow
http://eprints.gla.ac.uk/144365/1/144365.pdf
This study examined the effects of chemical chaperone treatment (sodium 4-phenylbutyrate) on ... clinical use for the treatment of urea cycle disorders.27.
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http://eprints.gla.ac.uk/144365/1/144365.pdf
This study examined the effects of chemical chaperone treatment (sodium 4-phenylbutyrate) on ... clinical use for the treatment of urea cycle disorders.27.
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56
Defective Trafficking of Nephrin Missense Mutants Rescued ...
https://jasn.asnjournals.org/content/15/7/1731
Chemical Chaperone Rescues Nephrin Missense Mutants from ER to the ... It has already been tested in clinical trials with patients with ...
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https://jasn.asnjournals.org/content/15/7/1731
Chemical Chaperone Rescues Nephrin Missense Mutants from ER to the ... It has already been tested in clinical trials with patients with ...
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57
The Chemical Chaperone, PBA, Reduces ER Stress and ...
https://facultyopinions.com/article/730230409
This study examined the effects of chemical chaperone treatment (sodium ... syndrome and missense mutations will only be determined with clinical trials.
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https://facultyopinions.com/article/730230409
This study examined the effects of chemical chaperone treatment (sodium ... syndrome and missense mutations will only be determined with clinical trials.
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58
Chemical chaperone 4-phenylbutyric acid protects H9c2 ...
https://www.spandidos-publications.com/10.3892/mmr.2016.5063
Previously, 4-PBA was found acting as a chemical chaperone in the ER, ... by the US Food and Drug Administration for clinical use (22).
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https://www.spandidos-publications.com/10.3892/mmr.2016.5063
Previously, 4-PBA was found acting as a chemical chaperone in the ER, ... by the US Food and Drug Administration for clinical use (22).
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59
chemical chaperone 4-phenylbutyrate: Topics by Science.gov
https://www.science.gov/topicpages/c/chemical+chaperone+4-phenylbutyrate
Therefore, ER stress-targeted therapy using a chemical chaperone is a promising novel strategy for trans-fatty acid-induced steatohepatitis. Clinical and ...
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https://www.science.gov/topicpages/c/chemical+chaperone+4-phenylbutyrate
Therefore, ER stress-targeted therapy using a chemical chaperone is a promising novel strategy for trans-fatty acid-induced steatohepatitis. Clinical and ...
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60
Chemical chaperone - Wikiwand
https://www.wikiwand.com/en/Chemical_chaperone
Beside clinical applications, chemical chaperones have proved useful in in vitro production of recombinant proteins. Re-folding of insoluble proteins from ...
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https://www.wikiwand.com/en/Chemical_chaperone
Beside clinical applications, chemical chaperones have proved useful in in vitro production of recombinant proteins. Re-folding of insoluble proteins from ...
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61
Identification of Chemical and Pharmacological Chaperones ...
https://molpharm.aspetjournals.org/content/99/6/460
; Achromatopsia Clinical Study Group (2008) Mutations in CNGA3 impair trafficking or function of cone cyclic nucleotide-gated channels, ...
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https://molpharm.aspetjournals.org/content/99/6/460
; Achromatopsia Clinical Study Group (2008) Mutations in CNGA3 impair trafficking or function of cone cyclic nucleotide-gated channels, ...
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62
"Chaperone" Compounds Offer New Approach to Alzheimer's ...
https://news.weill.cornell.edu/news/2014/04/chaperone-compounds-offer-new-approach-to-alzheimers-treatment
Image credit: Nature Chemical Biology and lab of Scott A. Small, MD/Columbia University Medical Center. Using computer-based virtual ...
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https://news.weill.cornell.edu/news/2014/04/chaperone-compounds-offer-new-approach-to-alzheimers-treatment
Image credit: Nature Chemical Biology and lab of Scott A. Small, MD/Columbia University Medical Center. Using computer-based virtual ...
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63
The chemical chaperone 4-phenylbutyrate inhibits ...
https://www.jlr.org/content/50/12/2486.full.pdf
of 4-phenylbutyrate (4-PBA), a well-established chemical chaperone and inhibitor of ER stress, on adipogenesis and weight gain in a diet-induced obesity ...
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https://www.jlr.org/content/50/12/2486.full.pdf
of 4-phenylbutyrate (4-PBA), a well-established chemical chaperone and inhibitor of ER stress, on adipogenesis and weight gain in a diet-induced obesity ...
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64
Chemical chaperone ameliorates pathological protein ...
https://bio.physik.fau.de/wp-publications/rn3036/
Chemical chaperone ameliorates pathological protein aggregation in ... url = {Winter J Clinical Invest 2014.pdf}, year = {2014}, ...
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https://bio.physik.fau.de/wp-publications/rn3036/
Chemical chaperone ameliorates pathological protein aggregation in ... url = {Winter J Clinical Invest 2014.pdf}, year = {2014}, ...
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65
Molecule of the Month: Chaperones - PDB-101
https://pdb101.rcsb.org/motm/32
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66
Potential prophylactic effect of chemical chaperones for ...
https://bnrc.springeropen.com/articles/10.1186/s42269-019-0089-7
The present research found that the tested chaperones could be used as a therapeutic approach for clinically relevant disorders featuring ER ...
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https://bnrc.springeropen.com/articles/10.1186/s42269-019-0089-7
The present research found that the tested chaperones could be used as a therapeutic approach for clinically relevant disorders featuring ER ...
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67
Chaperone therapy - Fabry Institute
https://fabry-institute.com/disease-management/chaperone-therapy
What is chaperone therapy for Fabry disease? Pharmacological chaperones are small-molecule ligands that selectively bind to and act upon unstable enzymes to ...
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https://fabry-institute.com/disease-management/chaperone-therapy
What is chaperone therapy for Fabry disease? Pharmacological chaperones are small-molecule ligands that selectively bind to and act upon unstable enzymes to ...
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68
Chaperone-assisted protein folding I: Chaperonins - iBiology
https://www.ibiology.org/cell-biology/chaperone/
00:19:57.10 devastating set of clinical conditions. 00:20:00.06 Thanks very much. Part 3: The Role of ATP Binding and Hydrolysis at ...
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https://www.ibiology.org/cell-biology/chaperone/
00:19:57.10 devastating set of clinical conditions. 00:20:00.06 Thanks very much. Part 3: The Role of ATP Binding and Hydrolysis at ...
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69
Potential Treatments for Protein Conformational Diseases
https://journaldatabase.info/articles/chemical_chaperone_inhibitor_discovery.html
Chemical Chaperone and Inhibitor Discovery: Potential Treatments for Protein Conformational Diseases. ADD TO MY LIST. Author(s): Jian-Hua Zhao | Hsuan-Liang ...
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https://journaldatabase.info/articles/chemical_chaperone_inhibitor_discovery.html
Chemical Chaperone and Inhibitor Discovery: Potential Treatments for Protein Conformational Diseases. ADD TO MY LIST. Author(s): Jian-Hua Zhao | Hsuan-Liang ...
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70
Mendeley Data FAIRest Datasets - Elsevier BV
https://elsevier.digitalcommonsdata.com/collections/46769202-3a48-4097-a6fb-1d056cf0d99d
Medical staff involved in the care of OHCA were given data collection forms ... chaperone genes in heterozygosis appeared as hits for our chemical genomic ...
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https://elsevier.digitalcommonsdata.com/collections/46769202-3a48-4097-a6fb-1d056cf0d99d
Medical staff involved in the care of OHCA were given data collection forms ... chaperone genes in heterozygosis appeared as hits for our chemical genomic ...
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71
New Study by Temple Researchers Is the First to Show ...
https://medicine.temple.edu/news/new-study-temple-researchers-first-show-pharmacological-chaperone-therapy-prevents-alzheimers
In a new study, scientists at the Lewis Katz School of Medicine describe a novel pharmacological chaperone capable of preventing Alzheimer's ...
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https://medicine.temple.edu/news/new-study-temple-researchers-first-show-pharmacological-chaperone-therapy-prevents-alzheimers
In a new study, scientists at the Lewis Katz School of Medicine describe a novel pharmacological chaperone capable of preventing Alzheimer's ...
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72
生命科学, 热门类期刊, - X-MOL
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Sliding droplets as the chemical version for identifying the number and type of ... NSW 2010, AustraliabSt Vincent's Clinical School, Faculty of Medicine, ...
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https://www.x-mol.com/paper/bio
Sliding droplets as the chemical version for identifying the number and type of ... NSW 2010, AustraliabSt Vincent's Clinical School, Faculty of Medicine, ...
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73
Protein Synthesis in Prokaryotes | Facts, Mechanism & Location
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74
Bacterial Disease Mechanisms An Introduction To Cellular ...
https://content.dev.cvilletomorrow.org/viewcontent?docid=58643&FileName=Bacterial%20Disease%20Mechanisms%20An%20Introduction%20To%20Cellular%20Microbiology.pdf
Measurements Current Protocols Chemical. Biology Jennifer Campbell Structure-Based ... insight into clinical applications of microbiology.
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https://content.dev.cvilletomorrow.org/viewcontent?docid=58643&FileName=Bacterial%20Disease%20Mechanisms%20An%20Introduction%20To%20Cellular%20Microbiology.pdf
Measurements Current Protocols Chemical. Biology Jennifer Campbell Structure-Based ... insight into clinical applications of microbiology.
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75
SHAREHOLDER ALERT: Pomerantz Law Firm ... - PR Newswire
https://www.prnewswire.com/news-releases/shareholder-alert-pomerantz-law-firm-reminds-shareholders-with-losses-on-their-investment-in-centessa-pharmaceuticals-plc-of-class-action-lawsuit-and-upcoming-deadline--cnta-301684430.html
Centessa is a clinical-stage pharmaceutical company that purports to ... a small molecule pharmacological chaperone folding corrector of the ...
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https://www.prnewswire.com/news-releases/shareholder-alert-pomerantz-law-firm-reminds-shareholders-with-losses-on-their-investment-in-centessa-pharmaceuticals-plc-of-class-action-lawsuit-and-upcoming-deadline--cnta-301684430.html
Centessa is a clinical-stage pharmaceutical company that purports to ... a small molecule pharmacological chaperone folding corrector of the ...
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76
Extensive N-Glycosylation Reduces the Thermal Stability of a ...
http://amp.turbo.fr/local-searching-02bj5CdjVmcpRWZj5WZpN2cuc3d39yL6MHc0/science/article/abs/pii/S1046592800913482
Alkalophilic Bacillus α-amylase (ABA) was produced in the yeast Pichia pastoris with a yield of 50 mg L−1 of culture supernatant. The recombinant protein ...
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http://amp.turbo.fr/local-searching-02bj5CdjVmcpRWZj5WZpN2cuc3d39yL6MHc0/science/article/abs/pii/S1046592800913482
Alkalophilic Bacillus α-amylase (ABA) was produced in the yeast Pichia pastoris with a yield of 50 mg L−1 of culture supernatant. The recombinant protein ...
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77
Could NSAIDs Like Ibuprofen, Aleve Make Arthritic Knees ...
https://www.polkio.com/lifestyles/health/could-nsaids-like-ibuprofen-aleve-make-arthritic-knees-worse/article_3bd9e81f-0449-51d5-a416-4fdaa1394ebb.html
NSAIDs block the production of body chemicals that cause inflammation. ... DiNubile agreed that a clinical trial is needed to confirm these ...
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https://www.polkio.com/lifestyles/health/could-nsaids-like-ibuprofen-aleve-make-arthritic-knees-worse/article_3bd9e81f-0449-51d5-a416-4fdaa1394ebb.html
NSAIDs block the production of body chemicals that cause inflammation. ... DiNubile agreed that a clinical trial is needed to confirm these ...
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78
Selphagy therapeutics - 89news.me
https://89news.me/selphagy-therapeutics.html
The study is titled, "Chaperone-mediated autophagy prevents collapse of the neuronal ... Clinical exam was not consistent with Mar 08, 2019 · Discussion.
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https://89news.me/selphagy-therapeutics.html
The study is titled, "Chaperone-mediated autophagy prevents collapse of the neuronal ... Clinical exam was not consistent with Mar 08, 2019 · Discussion.
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79
Jobs in Uganda - Great Uganda Jobs
https://www.greatugandajobs.com/jobs
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https://www.greatugandajobs.com/jobs
... Cipla Quality Chemical Industries Limited, CiplaQCIL, Citadel Capital (U) Limited, Citi Bank, Citigroup Uganda, Citizens Medical, City Ambulance Limited ...
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80
Dr. Zea Borok, MD | San Diego, CA - US News Health
https://health.usnews.com/doctors/zea-borok-414170
She received her medical degree from University of Cape Town Faculty of Medicine and has been in practice for more than 20 years. Specialties. Specialty.
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https://health.usnews.com/doctors/zea-borok-414170
She received her medical degree from University of Cape Town Faculty of Medicine and has been in practice for more than 20 years. Specialties. Specialty.
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81
Emery and Rimoin’s Principles and Practice of Medical ...
https://books.google.com/books?id=3ddKDwAAQBAJ&pg=PA646&lpg=PA646&dq=chemical+chaperone+clinical&source=bl&ots=LXKHRc1ow7&sig=ACfU3U1Zfg5unXsJ4vKNhNC9xZEYKw0_kQ&hl=en&sa=X&ved=2ahUKEwjdw6Ca78j7AhWfj4kEHSC1A44Q6AF6BQjOAhAD
Chemical chaperone therapy: clinical effect in murine G(M1)-gangliosidosis. Ann Neurol 2007;62(6):671–5. [43] Caciotti A, et al.
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https://books.google.com/books?id=3ddKDwAAQBAJ&pg=PA646&lpg=PA646&dq=chemical+chaperone+clinical&source=bl&ots=LXKHRc1ow7&sig=ACfU3U1Zfg5unXsJ4vKNhNC9xZEYKw0_kQ&hl=en&sa=X&ved=2ahUKEwjdw6Ca78j7AhWfj4kEHSC1A44Q6AF6BQjOAhAD
Chemical chaperone therapy: clinical effect in murine G(M1)-gangliosidosis. Ann Neurol 2007;62(6):671–5. [43] Caciotti A, et al.
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82
Pogil Packet Membrane Structure Copy
https://sindicaprocuradora.mazatlan.gob.mx/filedownload?docid=60541&FileName=Pogil%20Packet%20Membrane%20Structure.pdf
Chemistry in the Laboratory - James M. ... Medical Terminology for Health Professions ... mechanism of the major chaperone components,.
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https://sindicaprocuradora.mazatlan.gob.mx/filedownload?docid=60541&FileName=Pogil%20Packet%20Membrane%20Structure.pdf
Chemistry in the Laboratory - James M. ... Medical Terminology for Health Professions ... mechanism of the major chaperone components,.
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83
Advances in Clinical Chemistry - Page 114 - Google Books Result
https://books.google.com/books?id=4JtiCgAAQBAJ&pg=PA114&lpg=PA114&dq=chemical+chaperone+clinical&source=bl&ots=ArWmWjs5hU&sig=ACfU3U25PEUBZm-CrSBmJeU64ey9mF-fEg&hl=en&sa=X&ved=2ahUKEwjdw6Ca78j7AhWfj4kEHSC1A44Q6AF6BQjPAhAD
It is clearly demonstrated that cytokines can initiate the UPR response in β-cells in vitro, and relieving β-cell ER stress with PBA, a chemical chaperone ...
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https://books.google.com/books?id=4JtiCgAAQBAJ&pg=PA114&lpg=PA114&dq=chemical+chaperone+clinical&source=bl&ots=ArWmWjs5hU&sig=ACfU3U25PEUBZm-CrSBmJeU64ey9mF-fEg&hl=en&sa=X&ved=2ahUKEwjdw6Ca78j7AhWfj4kEHSC1A44Q6AF6BQjPAhAD
It is clearly demonstrated that cytokines can initiate the UPR response in β-cells in vitro, and relieving β-cell ER stress with PBA, a chemical chaperone ...
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84
Lei wang mt hood. Regulation of neural specification from ...
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Chemical Biology Laboratory. edu Academic Phone: (813) 974-1735 Education Lei Wang is ... 50-year-old Lei Cerebrovascular Medical Science, Tissue Factor in ...
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Chemical Biology Laboratory. edu Academic Phone: (813) 974-1735 Education Lei Wang is ... 50-year-old Lei Cerebrovascular Medical Science, Tissue Factor in ...
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85
Untitled
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York dcuc manual
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Untitled
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88
Severe Asthma: Toward Personalized Patient Management
https://books.google.com/books?id=2FE8DwAAQBAJ&pg=PA104&lpg=PA104&dq=chemical+chaperone+clinical&source=bl&ots=81-8swfVIt&sig=ACfU3U3jYdGrHUAZdpbRzruON4AVxrppzg&hl=en&sa=X&ved=2ahUKEwjdw6Ca78j7AhWfj4kEHSC1A44Q6AF6BQjVAhAD
Chemical chaperones, such as 4-PBA or tauroursodeoxycholic acid, were found to be extremely safe in preclinical studies and are now in clinical trials for ...
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Chemical chaperones, such as 4-PBA or tauroursodeoxycholic acid, were found to be extremely safe in preclinical studies and are now in clinical trials for ...
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89
Advances in Clinical Chemistry - Page 83 - Google Books Result
https://books.google.com/books?id=L-P7DwAAQBAJ&pg=PA83&lpg=PA83&dq=chemical+chaperone+clinical&source=bl&ots=tKJtPLcP4B&sig=ACfU3U3g8ZYsOnvjOr6MrcEWoguHMp3b6g&hl=en&sa=X&ved=2ahUKEwjdw6Ca78j7AhWfj4kEHSC1A44Q6AF6BQjWAhAD
... W.S. Sly, Signal sequence mutation in autosomal dominant form of hypoparathyroidism induces apoptosis that is corrected by a chemical chaperone, Proc.
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... W.S. Sly, Signal sequence mutation in autosomal dominant form of hypoparathyroidism induces apoptosis that is corrected by a chemical chaperone, Proc.
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90
N. W. Ayer & Son's American Newspaper Annual
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Ayer Directory of Publications - Part 1 - Page 488 - Google Books Result
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The IMS ... Ayer Directory of Publications
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Use of Chaperones During Sensitive Procedures and Exams
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