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Google Keyword Rankings for : morphine metabolites clinical implications
1
Opioid Metabolism - PMC - NCBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704133/
The M3G metabolite of morphine lacks analgesic activity, but it exhibits neuroexcitatory effects in animals and has been proposed as a potential cause of such ...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704133/
The M3G metabolite of morphine lacks analgesic activity, but it exhibits neuroexcitatory effects in animals and has been proposed as a potential cause of such ...
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2
Opioid Metabolites - Journal of Pain and Symptom Management
https://www.jpsmjournal.com/article/S0885-3924(05)00030-8/fulltext
With morphine, the active metabolite morphine-6- glucuronide exerts important clinical opioid effects when it accumulates in the plasma of patients with renal ...
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https://www.jpsmjournal.com/article/S0885-3924(05)00030-8/fulltext
With morphine, the active metabolite morphine-6- glucuronide exerts important clinical opioid effects when it accumulates in the plasma of patients with renal ...
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3
Serum and urine concentrations of morphine and morphine ...
https://bmcpalliatcare.biomedcentral.com/articles/10.1186/s12904-015-0052-9
Secondly, serum concentrations of morphine metabolites are known to be higher in patients with renal impairment and thus these patients have a ...
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https://bmcpalliatcare.biomedcentral.com/articles/10.1186/s12904-015-0052-9
Secondly, serum concentrations of morphine metabolites are known to be higher in patients with renal impairment and thus these patients have a ...
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4
Opioid Metabolism | Stanford Ether
https://ether.stanford.edu/urology/opiodmetabolism.pdf
The clinical effects of CYP2D6 allelic variants can be seen with codeine administration. ... who are unable to form the morphine metabolite*^ and in.
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https://ether.stanford.edu/urology/opiodmetabolism.pdf
The clinical effects of CYP2D6 allelic variants can be seen with codeine administration. ... who are unable to form the morphine metabolite*^ and in.
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5
The role of metabolites in morphine analgesic effects
https://journals.viamedica.pl/palliative_medicine_in_practice/article/viewFile/59347/47380
Institute of Experimental and Clinical Medicine, Medical Faculty, ... Morphine is metabolized into two main metabolites, morphine-3-glucuronide and ...
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https://journals.viamedica.pl/palliative_medicine_in_practice/article/viewFile/59347/47380
Institute of Experimental and Clinical Medicine, Medical Faculty, ... Morphine is metabolized into two main metabolites, morphine-3-glucuronide and ...
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6
Management of the paediatric patient receiving opioids
https://www.rch.org.au/rchcpg/hospital_clinical_guideline_index/Management_of_the_paediatric_patient_receiving_opioids/
Opioids are metabolised in the liver and excreted via the kidneys. Morphine is the most commonly used opioid of choice, and has two main metabolites M3G and M6G ...
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https://www.rch.org.au/rchcpg/hospital_clinical_guideline_index/Management_of_the_paediatric_patient_receiving_opioids/
Opioids are metabolised in the liver and excreted via the kidneys. Morphine is the most commonly used opioid of choice, and has two main metabolites M3G and M6G ...
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7
Medline ® Abstract for Reference 12 of 'Cancer pain ...
https://www.uptodate.com/contents/cancer-pain-management-with-opioids-optimizing-analgesia/abstract/12
The quantitative clinical importance of these metabolites following the administration of oral morphine is unclear. This study investigates the relationship ...
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https://www.uptodate.com/contents/cancer-pain-management-with-opioids-optimizing-analgesia/abstract/12
The quantitative clinical importance of these metabolites following the administration of oral morphine is unclear. This study investigates the relationship ...
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8
Pharmacokinetics of codeine and its metabolite morphine in ...
https://www.nature.com/articles/6500406
Possible side effects were monitored by a questionnaire involving dizziness, palpitations, nausea and obstipation. Assessments of the adverse ...
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https://www.nature.com/articles/6500406
Possible side effects were monitored by a questionnaire involving dizziness, palpitations, nausea and obstipation. Assessments of the adverse ...
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9
Opioid Pharmacology - Mass.gov
https://www.mass.gov/doc/trescot-et-al-2008/download
A number of opioids are available for clinical use, including morphine, ... and metabolism of opioids in an effort to better understand the side effects, ...
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https://www.mass.gov/doc/trescot-et-al-2008/download
A number of opioids are available for clinical use, including morphine, ... and metabolism of opioids in an effort to better understand the side effects, ...
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10
Metabolism of heroin and its pharmacologic implications
https://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1965-01-01_1_page006.html
Experimental Biotransformation of Heroin to MAM and Morphine in vitro ... Department of Pharmacology, University of California Medical Center, San Francisco ...
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https://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1965-01-01_1_page006.html
Experimental Biotransformation of Heroin to MAM and Morphine in vitro ... Department of Pharmacology, University of California Medical Center, San Francisco ...
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11
(PDF) Morphine metabolites: Clinical implications | Carsten Skarke ...
https://www.academia.edu/28334537/Morphine_metabolites_Clinical_implications
Morphine Metabolites: Clinical Implications Carsten Skarke and J6rn L6tsch ORPHINE, the major alkaloid of opium, heat). 8 Similarly, subcutaneous or ...
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https://www.academia.edu/28334537/Morphine_metabolites_Clinical_implications
Morphine Metabolites: Clinical Implications Carsten Skarke and J6rn L6tsch ORPHINE, the major alkaloid of opium, heat). 8 Similarly, subcutaneous or ...
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12
Metabolites of Tramadol in the Postoperative Surgical Patients
https://clinicaltrials.gov/ct2/show/NCT04004481
In case of inadequate analgesia rescue analgesic (morphine) will be used ... in patients with hepatic impairment: pharmacology and clinical implications.
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https://clinicaltrials.gov/ct2/show/NCT04004481
In case of inadequate analgesia rescue analgesic (morphine) will be used ... in patients with hepatic impairment: pharmacology and clinical implications.
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13
OPIOID PROBLEMS, AND MORPHINE METABOLISM AND ...
http://www.bandolier.org.uk/booth/painpag/wisdom/c14.html
The greater potency of M6G compared with morphine has important clinical implications [OSBORNE et al, 1990; MCQUAY et al, 1990]. It has long been known ...
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http://www.bandolier.org.uk/booth/painpag/wisdom/c14.html
The greater potency of M6G compared with morphine has important clinical implications [OSBORNE et al, 1990; MCQUAY et al, 1990]. It has long been known ...
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14
Pharmacogenomics and Opioid Analgesics: Clinical Implications
https://www.hindawi.com/journals/ijg/2015/368979/
The mu-opioid receptor is the primary site of action of opioid analgesics including morphine, fentanyl, and methadone. Although most of the currently prescribed ...
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https://www.hindawi.com/journals/ijg/2015/368979/
The mu-opioid receptor is the primary site of action of opioid analgesics including morphine, fentanyl, and methadone. Although most of the currently prescribed ...
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15
Opioid Dosing in Renal and Hepatic Impairment
https://www.uspharmacist.com/article/opioid-dosing-in-renal-and-hepatic-impairment
The following section will review clinical considerations when selecting an ... converting codeine to morphine and its metabolites much more ...
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https://www.uspharmacist.com/article/opioid-dosing-in-renal-and-hepatic-impairment
The following section will review clinical considerations when selecting an ... converting codeine to morphine and its metabolites much more ...
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16
Comparative clinical effects of hydromorphone and morphine
https://www.bjanaesthesia.org/article/S0007-0912(17)33069-6/pdf
Several case reports suggested that morphine's 6-glucuronide metabolite is responsible for sedation and nausea in patients with impaired renal ...
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https://www.bjanaesthesia.org/article/S0007-0912(17)33069-6/pdf
Several case reports suggested that morphine's 6-glucuronide metabolite is responsible for sedation and nausea in patients with impaired renal ...
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17
Plasma concentrations of morphine, morphine-6-glucuronide ...
https://journals.sagepub.com/doi/abs/10.1191/0269216303pm658oa
This study did not identify a simple relationship between plasma concentrations of morphine, morphine metabolites or metabolite ratios and clinical effects ...
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https://journals.sagepub.com/doi/abs/10.1191/0269216303pm658oa
This study did not identify a simple relationship between plasma concentrations of morphine, morphine metabolites or metabolite ratios and clinical effects ...
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18
Morphine metabolism, transport and brain disposition
https://link.springer.com/article/10.1007/s11011-011-9274-6
The chemical structures of morphine and its metabolites are closely related to the clinical effects of drugs (analgesia and side-effects) ...
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https://link.springer.com/article/10.1007/s11011-011-9274-6
The chemical structures of morphine and its metabolites are closely related to the clinical effects of drugs (analgesia and side-effects) ...
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19
Genetics and Opioids: Towards More Appropriate Prescription ...
https://www.mdpi.com/2072-6694/12/7/1951/htm
... on basic pharmacogenetic and its impact in the clinical scenario discussing how ... Pharmacokinetic profiles of morphine and its metabolites could help ...
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https://www.mdpi.com/2072-6694/12/7/1951/htm
... on basic pharmacogenetic and its impact in the clinical scenario discussing how ... Pharmacokinetic profiles of morphine and its metabolites could help ...
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20
Strategies to Manage the Adverse Effects of Oral Morphine
https://atriumhealth.org/documents/northeastinternalintegrative/research-library/postoperativeileus/strategiesadverseeffects.pdf
based recommendations for clinical-practice formu- lated by an Expert Working Group of the ... metabolite of morphine, morphine-6-glucuronide.24 Anec-.
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https://atriumhealth.org/documents/northeastinternalintegrative/research-library/postoperativeileus/strategiesadverseeffects.pdf
based recommendations for clinical-practice formu- lated by an Expert Working Group of the ... metabolite of morphine, morphine-6-glucuronide.24 Anec-.
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21
DILAUDID AND MORPHINE EFFECTS ON BASAL ...
https://jamanetwork.com/journals/jama/fullarticle/252721
DILAUDID AND MORPHINE EFFECTS ON BASAL METABOLISM AND OTHER BODY FUNCTIONS ... Physician / Medical Oncology Norwich Norwich, Connecticut.
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https://jamanetwork.com/journals/jama/fullarticle/252721
DILAUDID AND MORPHINE EFFECTS ON BASAL METABOLISM AND OTHER BODY FUNCTIONS ... Physician / Medical Oncology Norwich Norwich, Connecticut.
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22
Morphine Metabolism in Human Skin Microsomes - FullText
https://www.karger.com/Article/Fulltext/342067
Several clinical studies on topically applied opioids in severe skin wounds have shown that efficient analgesic effects can be obtained [for ...
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https://www.karger.com/Article/Fulltext/342067
Several clinical studies on topically applied opioids in severe skin wounds have shown that efficient analgesic effects can be obtained [for ...
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23
Full article: Pharmacokinetic considerations and ...
https://www.tandfonline.com/doi/full/10.1080/17425255.2016.1179281
Introduction: A variety of medications are used for symptom control in palliative care, such as morphine, midazolam and haloperidol.
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https://www.tandfonline.com/doi/full/10.1080/17425255.2016.1179281
Introduction: A variety of medications are used for symptom control in palliative care, such as morphine, midazolam and haloperidol.
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24
Pharmacokinetic Modeling of M6G Formation after Oral ...
https://pubs.asahq.org/anesthesiology/article/90/4/1026/37894/Pharmacokinetic-Modeling-of-M6G-Formation-after
metabolites, morphine-3-glucuronide (M3G) and mor- phine-6ß-glucuronide (M6G). Under certain circum- stances, they contribute to the clinical effects of mor ...
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https://pubs.asahq.org/anesthesiology/article/90/4/1026/37894/Pharmacokinetic-Modeling-of-M6G-Formation-after
metabolites, morphine-3-glucuronide (M3G) and mor- phine-6ß-glucuronide (M6G). Under certain circum- stances, they contribute to the clinical effects of mor ...
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25
Opiates - Mayo Clinic Laboratories
https://www.mayocliniclabs.com/test-catalog/drug-book/specific-drug-groups/opiates
Metabolites ; Heroin, 6-MAM Morphine ; Morphine, Hydromorphone (<3%) ; Codeine, Morphine, Hydrocodone (<11%) ; Hydrocodone, Hydromorphone Norhydrocodone ...
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https://www.mayocliniclabs.com/test-catalog/drug-book/specific-drug-groups/opiates
Metabolites ; Heroin, 6-MAM Morphine ; Morphine, Hydromorphone (<3%) ; Codeine, Morphine, Hydrocodone (<11%) ; Hydrocodone, Hydromorphone Norhydrocodone ...
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26
Opioid Metabolism and Effects of Cytochrome P450
https://academic.oup.com/painmedicine/article/10/suppl_1/S20/1914905
Additionally, genetic variability studies related to UGT metabolism of morphine has not been shown to alter levels of the production of its ...
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https://academic.oup.com/painmedicine/article/10/suppl_1/S20/1914905
Additionally, genetic variability studies related to UGT metabolism of morphine has not been shown to alter levels of the production of its ...
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27
Codeine and Morphine Pathway, Pharmacokinetics - PharmGKB
https://www.pharmgkb.org/pathway/PA146123006
In addition to their analgesic effects, both drugs have antitussive effects and antidiarrheal activity. Side effects include respiratory depression, ...
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https://www.pharmgkb.org/pathway/PA146123006
In addition to their analgesic effects, both drugs have antitussive effects and antidiarrheal activity. Side effects include respiratory depression, ...
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28
Clinical Pharmacology Considerations in Pain Management in ...
https://cjasn.asnjournals.org/content/14/6/917/tab-figures-data
Codeine, A weak opioid that is metabolized by the enzyme CYP2D6 in the liver to its active metabolite morphine, which provides the analgesic ...
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https://cjasn.asnjournals.org/content/14/6/917/tab-figures-data
Codeine, A weak opioid that is metabolized by the enzyme CYP2D6 in the liver to its active metabolite morphine, which provides the analgesic ...
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29
VA/DoD CLINICAL PRACTICE GUIDELINE FOR OPIOID ...
https://www.va.gov/HOMELESS/nchav/resources/docs/mental-health/substance-abuse/VA_DoD-CLINICAL-PRACTICE-GUIDELINE-FOR-OPIOID-THERAPY-FOR-CHRONIC-PAIN-508.pdf
We recommend against opioid doses over 90 mg morphine equivalent ... aimed at fixing or numbing pain with medications, interventions, or surgery, ...
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https://www.va.gov/HOMELESS/nchav/resources/docs/mental-health/substance-abuse/VA_DoD-CLINICAL-PRACTICE-GUIDELINE-FOR-OPIOID-THERAPY-FOR-CHRONIC-PAIN-508.pdf
We recommend against opioid doses over 90 mg morphine equivalent ... aimed at fixing or numbing pain with medications, interventions, or surgery, ...
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30
Codeine Intoxication Associated with Ultrarapid CYP2D6 ...
https://www.nejm.org/doi/full/10.1056/nejmoa041888
O-demethylation of codeine into morphine by CYP2D6 represents a minor pathway of codeine metabolism (accounting for less than 10 percent of ...
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https://www.nejm.org/doi/full/10.1056/nejmoa041888
O-demethylation of codeine into morphine by CYP2D6 represents a minor pathway of codeine metabolism (accounting for less than 10 percent of ...
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31
How codeine metabolism affects its clinical use
https://pharmaceutical-journal.com/article/ld/how-codeine-metabolism-affects-its-clinical-use
This maximum has been derived in part from studies indicating that dose escalations beyond this point cause an increase in adverse effects — ...
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https://pharmaceutical-journal.com/article/ld/how-codeine-metabolism-affects-its-clinical-use
This maximum has been derived in part from studies indicating that dose escalations beyond this point cause an increase in adverse effects — ...
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32
Opioid Pharmacokinetic Drug-Drug Interactions
https://www.ajmc.com/view/a370_11sep_overholser_s276tos287
The metabolites that account for the analgesic effects of codeine are morphine and M6G.34 Morphine is formed following an O-demethylation of ...
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https://www.ajmc.com/view/a370_11sep_overholser_s276tos287
The metabolites that account for the analgesic effects of codeine are morphine and M6G.34 Morphine is formed following an O-demethylation of ...
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33
Morphine-3-Glucuronide, Physiology and Behavior - Frontiers
https://www.frontiersin.org/articles/10.3389/fnmol.2022.882443/full
Morphine metabolism leads to the production of two predominant metabolites, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G). This metabolism ...
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https://www.frontiersin.org/articles/10.3389/fnmol.2022.882443/full
Morphine metabolism leads to the production of two predominant metabolites, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G). This metabolism ...
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34
The Metabolism of Opioid Agents and the Clinical Impact of Their ...
https://www.semanticscholar.org/paper/The-Metabolism-of-Opioid-Agents-and-the-Clinical-of-Smith/2e96240b82abfe355c5a021b7fa18fc668c5dc4f
A greater appreciation of the metabolism of commonly prescribed opioid analgesics and the impact of their active metabolites on efficacy and safety may aid ...
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https://www.semanticscholar.org/paper/The-Metabolism-of-Opioid-Agents-and-the-Clinical-of-Smith/2e96240b82abfe355c5a021b7fa18fc668c5dc4f
A greater appreciation of the metabolism of commonly prescribed opioid analgesics and the impact of their active metabolites on efficacy and safety may aid ...
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35
Do genes affect morphine response? | Pharmacogenomics
https://www.futuremedicine.com/doi/10.2217/pgs-2017-0138
Thus, the clinical impact of UGT2B7 variants is debatable and further ... important due to their scarce role in morphine metabolism.
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https://www.futuremedicine.com/doi/10.2217/pgs-2017-0138
Thus, the clinical impact of UGT2B7 variants is debatable and further ... important due to their scarce role in morphine metabolism.
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36
Morphine metabolites: A review of their clinical effects
https://www.researchgate.net/publication/286221709_Morphine_metabolites_A_review_of_their_clinical_effects
... The accumulation of morphine and M-6-G may cause nausea and vomiting, sedation, and finally, respiratory depression. Morphine-3-glucuronide ...
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https://www.researchgate.net/publication/286221709_Morphine_metabolites_A_review_of_their_clinical_effects
... The accumulation of morphine and M-6-G may cause nausea and vomiting, sedation, and finally, respiratory depression. Morphine-3-glucuronide ...
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37
Distinct pharmacological properties of morphine metabolites ...
https://hal.archives-ouvertes.fr/hal-00690183/document
Opioid metabolism. Mayo Clin Proc 2009; 84: 613-24. [7] Skarke C, Lötsch J. Morphine metabolites: clinical implications. Seminars in.
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https://hal.archives-ouvertes.fr/hal-00690183/document
Opioid metabolism. Mayo Clin Proc 2009; 84: 613-24. [7] Skarke C, Lötsch J. Morphine metabolites: clinical implications. Seminars in.
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38
Interpretation of Urine Drug Screens Metabolites and Impurities
https://www.oregonpainguidance.org/wp-content/uploads/2018/02/Interpretation-of-UDS-JAMA-2017.pdf
The patient is taking methadone and morphine. Test Characteristics. With the increasing opioid dependence epidemic, clinicians must monitor the use of ...
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https://www.oregonpainguidance.org/wp-content/uploads/2018/02/Interpretation-of-UDS-JAMA-2017.pdf
The patient is taking methadone and morphine. Test Characteristics. With the increasing opioid dependence epidemic, clinicians must monitor the use of ...
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39
Metabolism and Analysis of Desomorphine
https://www.ojp.gov/pdffiles1/nij/grants/254755.pdf
identification in clinical and forensic toxicology laboratories. ... Additionally, LC-Q/TOF-MS was used to analyze desomorphine metabolites, which in the.
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https://www.ojp.gov/pdffiles1/nij/grants/254755.pdf
identification in clinical and forensic toxicology laboratories. ... Additionally, LC-Q/TOF-MS was used to analyze desomorphine metabolites, which in the.
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40
Interpretation of Opiate Urine Drug Screens - HealthPartners
https://www.healthpartners.com/ucm/groups/public/@hp/@public/@ime/@content/documents/documents/cntrb_031044.pdf
The immunoassay for opiates is primarily targeted to detecting morphine, hydrocodone, dihydrocodeine, codeine, 6-acetylmorphine (metabolite of heroin), and.
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https://www.healthpartners.com/ucm/groups/public/@hp/@public/@ime/@content/documents/documents/cntrb_031044.pdf
The immunoassay for opiates is primarily targeted to detecting morphine, hydrocodone, dihydrocodeine, codeine, 6-acetylmorphine (metabolite of heroin), and.
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41
What did my Patient Actually Take? An Overview of Opioid ...
https://www.aegislabs.com/resources/clinical-update/opioid-results
Drugs that inhibit or induce the CYP3A4 route of metabolism can modify the effect of opioids, leading to either a decrease in analgesic effects ...
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https://www.aegislabs.com/resources/clinical-update/opioid-results
Drugs that inhibit or induce the CYP3A4 route of metabolism can modify the effect of opioids, leading to either a decrease in analgesic effects ...
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42
Morphine: Uses, Interactions, Mechanism of Action - DrugBank
https://go.drugbank.com/drugs/DB00295
The metabolism of Morphine can be decreased when combined with Amprenavir. Amyl Nitrite, The risk or severity of adverse effects can be increased when Morphine ...
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https://go.drugbank.com/drugs/DB00295
The metabolism of Morphine can be decreased when combined with Amprenavir. Amyl Nitrite, The risk or severity of adverse effects can be increased when Morphine ...
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43
Detecting opioid metabolites in exhaled breath condensate ...
https://iopscience.iop.org/article/10.1088/1752-7163/ab35fd
Morphine has a broad variability in both analgesics and adverse effects. It is mainly metabolized in vivo to morphine-3-glucuronide and ...
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https://iopscience.iop.org/article/10.1088/1752-7163/ab35fd
Morphine has a broad variability in both analgesics and adverse effects. It is mainly metabolized in vivo to morphine-3-glucuronide and ...
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44
6-Monoacetylmorphine (6-MAM), Not Morphine, Is ...
https://pubs.acs.org/doi/10.1021/acschemneuro.9b00305
The effects of morphine, the second metabolite of heroin, differed drastically from those of heroin. In both doses tested, morphine only ...
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https://pubs.acs.org/doi/10.1021/acschemneuro.9b00305
The effects of morphine, the second metabolite of heroin, differed drastically from those of heroin. In both doses tested, morphine only ...
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45
A Prospective Population Pharmacokinetic Study ... - DiVA Portal
https://www.diva-portal.org/smash/get/diva2:1085772/FULLTEXT01.pdf
between treatment failure and morphine and metabolite ... causes for this variability and its effects on clinical out-.
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https://www.diva-portal.org/smash/get/diva2:1085772/FULLTEXT01.pdf
between treatment failure and morphine and metabolite ... causes for this variability and its effects on clinical out-.
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46
Palliative Care in Patients with Kidney Disease and Cancer
https://www.asn-online.org/education/distancelearning/curricula/onco/Chapter19.pdf
of the failure of renal excretion of active metabolites ... to manage the complicated adverse effects of the morphine metabolites (12).
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https://www.asn-online.org/education/distancelearning/curricula/onco/Chapter19.pdf
of the failure of renal excretion of active metabolites ... to manage the complicated adverse effects of the morphine metabolites (12).
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47
Comparative Clinical Effects of Hydromorphone and Morphine
https://journals.lww.com/surveyanesthesiology/fulltext/2012/04000/Comparative_Clinical_Effects_of_Hydromorphone_and.38.aspx
Other potential clinical pharmacological advantages related to adverse effects, such as safety in renal failure or during acute analgesia titration, are based ...
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https://journals.lww.com/surveyanesthesiology/fulltext/2012/04000/Comparative_Clinical_Effects_of_Hydromorphone_and.38.aspx
Other potential clinical pharmacological advantages related to adverse effects, such as safety in renal failure or during acute analgesia titration, are based ...
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48
does grapefruit juice enhance the clinical effects of oral ...
https://www.ctsi.ucla.edu/education/files/view/training/docs/McKeeverRI.pdf
*When the increased or decreased absorption effects of food are undesirable, ... Morphine → Morphine -6-glucuronide (active metabolite)/5-10%.
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https://www.ctsi.ucla.edu/education/files/view/training/docs/McKeeverRI.pdf
*When the increased or decreased absorption effects of food are undesirable, ... Morphine → Morphine -6-glucuronide (active metabolite)/5-10%.
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49
A Prospective Population Pharmacokinetic Study on Morphine ...
https://repub.eur.nl/pub/94166/REPUB_94166.pdf
morphine or its metabolites was not found to be correlated with treatment failure. ... causes for this variability and its effects on clinical out-.
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https://repub.eur.nl/pub/94166/REPUB_94166.pdf
morphine or its metabolites was not found to be correlated with treatment failure. ... causes for this variability and its effects on clinical out-.
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50
Clinical pharmacology of morphine and morphine-6 ...
https://www.esteve.org/wp-content/uploads/2018/01/138289.pdf
2001 Elsevier Science B.V.. All rights reserved. Keywords M6G, Opioid; Metabolite. 1. Pharmacological effects of morphine and M6G from a PK/PD modeling.
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https://www.esteve.org/wp-content/uploads/2018/01/138289.pdf
2001 Elsevier Science B.V.. All rights reserved. Keywords M6G, Opioid; Metabolite. 1. Pharmacological effects of morphine and M6G from a PK/PD modeling.
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51
Physiologically based pharmacokinetic/pharmacodynamic ...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008786
A PB-PK/PD model was developed for morphine and its active metabolite morphine-6-glucuronide. Measured data corresponded well with simulated ...
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https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008786
A PB-PK/PD model was developed for morphine and its active metabolite morphine-6-glucuronide. Measured data corresponded well with simulated ...
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52
Morphine Sulfate tablets label - Accessdata.fda.gov
https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022207s004lbl.pdf
clinical decisions over time in the management of the pain of each individual ... depressant effects of morphine sulfate and its potential to elevate ...
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https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022207s004lbl.pdf
clinical decisions over time in the management of the pain of each individual ... depressant effects of morphine sulfate and its potential to elevate ...
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53
DISPOSITION OF MORPHINE-6-GLUCURONIDE AND ...
https://www.bjanaesthesia.org.uk/article/S0007-0912(17)48258-4/pdf
Pharmacologically active metabolites are of great interest to clinicians as they may augment or inhibit the effects of the parent drug, or enhance.
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https://www.bjanaesthesia.org.uk/article/S0007-0912(17)48258-4/pdf
Pharmacologically active metabolites are of great interest to clinicians as they may augment or inhibit the effects of the parent drug, or enhance.
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54
Alternative opioids to morphine in palliative care
https://pmj.bmj.com/content/77/908/371
Methadone has an additional action as an NMDA receptor antagonist—the clinical significance of this is that it may confer improved analgesic effects when ...
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https://pmj.bmj.com/content/77/908/371
Methadone has an additional action as an NMDA receptor antagonist—the clinical significance of this is that it may confer improved analgesic effects when ...
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55
Heroin drug profile - emcdda - European Union
https://www.emcdda.europa.eu/publications/drug-profiles/heroin_en
Negative effects include respiratory depression, nausea and vomiting, decreased motility in the gastrointestinal tract, suppression of the cough reflex and ...
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https://www.emcdda.europa.eu/publications/drug-profiles/heroin_en
Negative effects include respiratory depression, nausea and vomiting, decreased motility in the gastrointestinal tract, suppression of the cough reflex and ...
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56
Using Over-the-Counter and Other Prescription Medications to ...
https://www.heraldopenaccess.us/openaccess/using-over-the-counter-and-other-prescription-medications-to-potentiate-opiates-in-the-usa-literature-review-medical-and-public-health-aspects-of-otc-medication-misuse
In addition to rewarding effects, the non-clinical use of substances such as ... Cimetidine is likely to affect the metabolism of codeine to morphine.
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https://www.heraldopenaccess.us/openaccess/using-over-the-counter-and-other-prescription-medications-to-potentiate-opiates-in-the-usa-literature-review-medical-and-public-health-aspects-of-otc-medication-misuse
In addition to rewarding effects, the non-clinical use of substances such as ... Cimetidine is likely to affect the metabolism of codeine to morphine.
→ Check Latest Keyword Rankings ←
57
Clinical Drug Testing in Primary Care - SAMHSA Publications
https://store.samhsa.gov/sites/default/files/d7/priv/sma12-4668.pdf
Cannabinoid metabolite (delta-9-tetrahydrocannabinol-9-carboxylic acid). 15. Cocaine metabolite (benzoylecgonine). 100. Codeine. 2,000. Morphine.
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https://store.samhsa.gov/sites/default/files/d7/priv/sma12-4668.pdf
Cannabinoid metabolite (delta-9-tetrahydrocannabinol-9-carboxylic acid). 15. Cocaine metabolite (benzoylecgonine). 100. Codeine. 2,000. Morphine.
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58
Management of opioid side effects in cancer-related and ...
https://www.jpain.org/article/S1526-5900(03)00556-X/abstract
The side effects studied were constipation, pruritus, nausea and vomiting, myoclonus, sedation, respiratory depression, and delirium. Opioid rotation to manage ...
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https://www.jpain.org/article/S1526-5900(03)00556-X/abstract
The side effects studied were constipation, pruritus, nausea and vomiting, myoclonus, sedation, respiratory depression, and delirium. Opioid rotation to manage ...
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59
Opioid analgesics-related pharmacokinetic drug interactions
https://www.dovepress.com/opioid-analgesics-related-pharmacokinetic-drug-interactions-from-the-p-peer-reviewed-fulltext-article-JPR
An RCT in healthy volunteers showed that 5 mg of i.v. morphine could reduce the peak concentration (Cmax) of prasugrel active metabolite by 31% ...
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https://www.dovepress.com/opioid-analgesics-related-pharmacokinetic-drug-interactions-from-the-p-peer-reviewed-fulltext-article-JPR
An RCT in healthy volunteers showed that 5 mg of i.v. morphine could reduce the peak concentration (Cmax) of prasugrel active metabolite by 31% ...
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60
Pharmacology of morphine in obese patients - Gale
https://go.gale.com/ps/i.do?id=GALE%7CA217606179&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=03125963&p=AONE&sw=w
In addition, drug-drug interactions may alter the disposition of morphine and its glucuronide metabolites, which may either increase the risk of adverse effects ...
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https://go.gale.com/ps/i.do?id=GALE%7CA217606179&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=03125963&p=AONE&sw=w
In addition, drug-drug interactions may alter the disposition of morphine and its glucuronide metabolites, which may either increase the risk of adverse effects ...
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61
Implications in Morphine Tolerance and Abnormal Pain S
https://www.jneurosci.org/content/jneuro/22/18/8312.full.pdf
effects, the clinical utility of opioid analgesics is often hampered ... metabolites (6-monoacetylmorphine or morphine) do indeed in-.
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https://www.jneurosci.org/content/jneuro/22/18/8312.full.pdf
effects, the clinical utility of opioid analgesics is often hampered ... metabolites (6-monoacetylmorphine or morphine) do indeed in-.
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62
Pain polymorphisms and opioids: An evidence based review
https://www.spandidos-publications.com/10.3892/mmr.2018.9792
Clinical trials were related with polymorphisms in CYP2B6 (metabolism of ketamine), CYP2D6 (analgesia of tramadol) and UGT2B7 (morphine). One ...
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https://www.spandidos-publications.com/10.3892/mmr.2018.9792
Clinical trials were related with polymorphisms in CYP2B6 (metabolism of ketamine), CYP2D6 (analgesia of tramadol) and UGT2B7 (morphine). One ...
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63
Morphine Sulfate 2mg in 1mL Solution for Injection - (emc)
https://www.medicines.org.uk/emc/product/1988/smpc
The side-effects most commonly seen with morphine and other opioids are respiratory depression, nausea, vomiting, constipation, drowsiness and confusion. With ...
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https://www.medicines.org.uk/emc/product/1988/smpc
The side-effects most commonly seen with morphine and other opioids are respiratory depression, nausea, vomiting, constipation, drowsiness and confusion. With ...
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64
Opioid Analgesics and the Gastrointestinal Tract
https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2015/11/ChanArticle-August-08.pdf
Most of the clinical effects observed with opioid use are μ receptor-mediated. ... macologically active metabolites, of which morphine-.
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https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2015/11/ChanArticle-August-08.pdf
Most of the clinical effects observed with opioid use are μ receptor-mediated. ... macologically active metabolites, of which morphine-.
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65
Comparative clinical effects of hydromorphone and morphine
https://dolor.org.co/biblioteca/articulos/articulos/Efectos%20cl%ADnicos%20hidromorfona%20morfina.pdf
We have conducted a meta-analysis of the clinical effects of morphine and ... not form an active 6-glucuronide metabolite like morphine.7.
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https://dolor.org.co/biblioteca/articulos/articulos/Efectos%20cl%ADnicos%20hidromorfona%20morfina.pdf
We have conducted a meta-analysis of the clinical effects of morphine and ... not form an active 6-glucuronide metabolite like morphine.7.
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66
DBL Morphine Tartrate Injection - NEW ZEALAND DATA SHEET
https://www.medsafe.govt.nz/profs/datasheet/d/dblMorphinetartrateinj.pdf
and other side effects which obscure the clinical course in patients with head injuries. ... Zidovudine: Morphine may alter the metabolism of zidovudine, ...
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https://www.medsafe.govt.nz/profs/datasheet/d/dblMorphinetartrateinj.pdf
and other side effects which obscure the clinical course in patients with head injuries. ... Zidovudine: Morphine may alter the metabolism of zidovudine, ...
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67
Strategies to Manage the Adverse Effects of Oral Morphine
https://ascopubs.org/doi/10.1200/jco.2001.19.9.2542
The clinical challenge of selecting the best option is enhanced by ... Drugs that may alter opioid absorption, metabolism, or clearance of ...
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https://ascopubs.org/doi/10.1200/jco.2001.19.9.2542
The clinical challenge of selecting the best option is enhanced by ... Drugs that may alter opioid absorption, metabolism, or clearance of ...
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68
Clinically relevant concentrations of opioids for in vitro studies
https://www.wmpllc.org/ojs/index.php/jom/article/view/391
Concentrations of the opioids from previous clinical studies were mostly ... Liu Z, Gao F, Tian Y: Effects of morphine, fentanyl and tramadol on human ...
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https://www.wmpllc.org/ojs/index.php/jom/article/view/391
Concentrations of the opioids from previous clinical studies were mostly ... Liu Z, Gao F, Tian Y: Effects of morphine, fentanyl and tramadol on human ...
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69
MS-Contin: Opioids, Used For Pain, Dosage, Side ... - RxList
https://www.rxlist.com/ms-contin-drug.htm
Clinical Impact: The concomitant use of cimetidine can potentiate morphine effects and increase risk of hypotension, respiratory depression, profound sedation, ...
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https://www.rxlist.com/ms-contin-drug.htm
Clinical Impact: The concomitant use of cimetidine can potentiate morphine effects and increase risk of hypotension, respiratory depression, profound sedation, ...
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70
Genetic Factors in Drug Metabolism | AAFP
https://www.aafp.org/pubs/afp/issues/2008/0601/p1553.html
Clinical Consequence of Metabolizer Phenotypes on Drug Response ; Prodrug, needs metabolism to work (e.g., codeine metabolized to morphine) ...
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https://www.aafp.org/pubs/afp/issues/2008/0601/p1553.html
Clinical Consequence of Metabolizer Phenotypes on Drug Response ; Prodrug, needs metabolism to work (e.g., codeine metabolized to morphine) ...
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71
Plasma Morphine and Metabolite Concentrations Are ...
https://www.infona.pl/resource/bwmeta1.element.elsevier-1ebe80ce-344b-3c1f-bd06-de4f177f6345
Original Article. Plasma Morphine and Metabolite Concentrations Are Associated With Clinical Effects of Morphine in Cancer Patients · Source · Abstract.
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https://www.infona.pl/resource/bwmeta1.element.elsevier-1ebe80ce-344b-3c1f-bd06-de4f177f6345
Original Article. Plasma Morphine and Metabolite Concentrations Are Associated With Clinical Effects of Morphine in Cancer Patients · Source · Abstract.
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72
Opioids and antidepressants: which combinations to avoid
https://www.nps.org.au/australian-prescriber/articles/opioids-and-antidepressants-which-combinations-to-avoid
Some selective serotonin reuptake inhibitors block the metabolism of ... and risk of adverse effects of other opioids such as methadone.
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https://www.nps.org.au/australian-prescriber/articles/opioids-and-antidepressants-which-combinations-to-avoid
Some selective serotonin reuptake inhibitors block the metabolism of ... and risk of adverse effects of other opioids such as methadone.
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73
CLINICAL PRACTICE GUIDELINE: CYP2D6 GENOTYPING ...
https://www.jptcp.com/index.php/jptcp/article/view/368?articlesBySameAuthorPage=2
Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid ... Pharmacogenetic determination of the effects of codeine and ...
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https://www.jptcp.com/index.php/jptcp/article/view/368?articlesBySameAuthorPage=2
Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid ... Pharmacogenetic determination of the effects of codeine and ...
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74
Opioids: What They Are, Side Effects & Disorders
https://my.clevelandclinic.org/health/articles/21127-opioids
Common opiates include opium, heroin morphine and codeine. ... they may have poor excretion and metabolism, which may result in the ...
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https://my.clevelandclinic.org/health/articles/21127-opioids
Common opiates include opium, heroin morphine and codeine. ... they may have poor excretion and metabolism, which may result in the ...
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75
Clinical_and_pharmacological_a.pdf - UCL Discovery
https://discovery.ucl.ac.uk/id/eprint/10123274/1/Clinical_and_pharmacological_a.pdf
7.c Morphine metabolites. 264. 7.b Controlled release morphine tablets. 265. 7.e Enterohepatic circulation of morphine. 265. 7.f Clinical use of opioid ...
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https://discovery.ucl.ac.uk/id/eprint/10123274/1/Clinical_and_pharmacological_a.pdf
7.c Morphine metabolites. 264. 7.b Controlled release morphine tablets. 265. 7.e Enterohepatic circulation of morphine. 265. 7.f Clinical use of opioid ...
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76
Morphine - Wikipedia
https://en.wikipedia.org/wiki/Morphine
Morphine is addictive and prone to abuse. ... If one's dose is reduced after long-term use, opioid withdrawal symptoms may occur. ... Common side effects of ...
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https://en.wikipedia.org/wiki/Morphine
Morphine is addictive and prone to abuse. ... If one's dose is reduced after long-term use, opioid withdrawal symptoms may occur. ... Common side effects of ...
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77
Impact of Opioid Use in Hematological Malignancies: Clinical ...
https://www.thejh.org/index.php/jh/article/view/689/476
These findings confirm the pro-angiogenic effects of morphine and other opioid agents. However, high doses of morphine have also been shown to inhibit the pro- ...
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https://www.thejh.org/index.php/jh/article/view/689/476
These findings confirm the pro-angiogenic effects of morphine and other opioid agents. However, high doses of morphine have also been shown to inhibit the pro- ...
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78
Which Opioids Are Safest and Most Effective in Renal Failure ...
https://www.clinicalkey.com/#!/content/book/3-s2.0-B9781437737967000069?scrollTo=%23hl0000304
Of all of the opioids, the metabolism of morphine is the most studied. ... of M6G in patients with reduced renal function has clinical implications.
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https://www.clinicalkey.com/#!/content/book/3-s2.0-B9781437737967000069?scrollTo=%23hl0000304
Of all of the opioids, the metabolism of morphine is the most studied. ... of M6G in patients with reduced renal function has clinical implications.
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79
Morphine: MedlinePlus Drug Information
https://medlineplus.gov/druginfo/meds/a682133.html
Morphine: learn about side effects, dosage, special precautions, ... call your doctor immediately or get emergency medical treatment: slowed ...
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https://medlineplus.gov/druginfo/meds/a682133.html
Morphine: learn about side effects, dosage, special precautions, ... call your doctor immediately or get emergency medical treatment: slowed ...
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80
Morphine pharmacokinetics and metabolism in humans ...
https://eurekamag.com/research/009/051/009051680.php
Hasselström, J.; Säwe, J., 1993: Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and ... Clinical Pharmacokinetics 24(4): 344-354
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https://eurekamag.com/research/009/051/009051680.php
Hasselström, J.; Säwe, J., 1993: Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and ... Clinical Pharmacokinetics 24(4): 344-354
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81
MORPHINE SULFATE (NEXTJECT) Clinical Pharmacology ...
https://www.pfizermedicalinformation.com/en-us/morphine-sulfate/clinical-pharmacology
Morphine is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. The ...
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https://www.pfizermedicalinformation.com/en-us/morphine-sulfate/clinical-pharmacology
Morphine is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. The ...
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82
Persistent pain associated with long-term intrathecal morphine ...
https://pennstate.pure.elsevier.com/en/publications/persistent-pain-associated-with-long-term-intrathecal-morphine-ad
Plasma and urine ratios of morphine metabolites morphine-3- glucuronide and ... in patients resistant to opioids may have potential clinical implications.
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https://pennstate.pure.elsevier.com/en/publications/persistent-pain-associated-with-long-term-intrathecal-morphine-ad
Plasma and urine ratios of morphine metabolites morphine-3- glucuronide and ... in patients resistant to opioids may have potential clinical implications.
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83
What You Need to Know About Morphine Side Effects
https://www.healthline.com/health/pain-relief/morphine-side-effects
metabolism; liver and kidney function; how long you've been taking morphine; if you've taken any type of opioid before; dosage; any medical ...
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https://www.healthline.com/health/pain-relief/morphine-side-effects
metabolism; liver and kidney function; how long you've been taking morphine; if you've taken any type of opioid before; dosage; any medical ...
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84
Heroin & Morphine | Metabolism & Mechanism of Action
https://www.youtube.com/watch?v=T2rMyDT6B-Y
Morphine Side Effects and Mechanism of Action | Opioid Analgesics. NursingSOS. NursingSOS. •. 31K views 1 year ago ...
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https://www.youtube.com/watch?v=T2rMyDT6B-Y
Morphine Side Effects and Mechanism of Action | Opioid Analgesics. NursingSOS. NursingSOS. •. 31K views 1 year ago ...
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85
Morphine Addiction, Withdrawal, Side Effects, Alternatives ...
https://www.alternativetomeds.com/blog/morphine/
Morphine is a prescription drug but also has a high potential for abuse due to the euphoria and relaxation effects that it causes. It is highly ...
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https://www.alternativetomeds.com/blog/morphine/
Morphine is a prescription drug but also has a high potential for abuse due to the euphoria and relaxation effects that it causes. It is highly ...
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86
Morphine metabolites: Clinical implications - EM consulte
https://www.em-consulte.com/article/539345/article/morphine-metabolites-clinical-implications
Seminars in Anesthesia, Perioperative Medicine and Pain - Vol. 21 - N° 4 - p. 258-264 - Morphine metabolites: Clinical implications - EM consulte.
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https://www.em-consulte.com/article/539345/article/morphine-metabolites-clinical-implications
Seminars in Anesthesia, Perioperative Medicine and Pain - Vol. 21 - N° 4 - p. 258-264 - Morphine metabolites: Clinical implications - EM consulte.
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87
Seminars in Anesthesia, Perioperative Medicine and Pain | Scholars ...
https://journals.scholarsportal.info/browse/02770326/v21i0004
Experts discuss a single topic from their clinical experience in each issue. ... Morphine metabolites: Clinical implications. Authors.
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https://journals.scholarsportal.info/browse/02770326/v21i0004
Experts discuss a single topic from their clinical experience in each issue. ... Morphine metabolites: Clinical implications. Authors.
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88
Opioid-Induced Hyperalgesia: An Emerging Treatment Challenge
https://christchurch-albion.org/article/opioid-induced-hyperalgesia-an-emerging-treatment-challenge.htm
Pain is the most common reason that people seek medical attention.1 A recent study ... Skarke C, Lötsch J. Morphine metabolites: clinical implications.
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https://christchurch-albion.org/article/opioid-induced-hyperalgesia-an-emerging-treatment-challenge.htm
Pain is the most common reason that people seek medical attention.1 A recent study ... Skarke C, Lötsch J. Morphine metabolites: clinical implications.
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89
Serum and urine concentrations of morphine and ... - NTNU Open
https://ntnuopen.ntnu.no/ntnu-xmlui/handle/11250/2657951?show=full
Serum and urine concentrations of morphine and morphine metabolites in patients ... feasibility and clinical implication of drug monitoring of morphine, ...
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https://ntnuopen.ntnu.no/ntnu-xmlui/handle/11250/2657951?show=full
Serum and urine concentrations of morphine and morphine metabolites in patients ... feasibility and clinical implication of drug monitoring of morphine, ...
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90
Opiate Test Interpretation - ClinLab Navigator
http://www.clinlabnavigator.com/opiate-test-interpretation.html
The Emit II Plus Opiate Assay tests for morphine, morphine-3-glucuronide, ... Negative or any metabolites not listed, Oxycodone & oxymorphone detected.
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http://www.clinlabnavigator.com/opiate-test-interpretation.html
The Emit II Plus Opiate Assay tests for morphine, morphine-3-glucuronide, ... Negative or any metabolites not listed, Oxycodone & oxymorphone detected.
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91
Drug Fact Sheet: Morphine - DEA.gov
https://www.dea.gov/sites/default/files/2020-06/Morphine-2020.pdf
Which drugs cause similar effects? Drugs causing similar effects as morphine include: • Opium, codeine, heroin, methadone, hydrocodone, fentanyl ...
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https://www.dea.gov/sites/default/files/2020-06/Morphine-2020.pdf
Which drugs cause similar effects? Drugs causing similar effects as morphine include: • Opium, codeine, heroin, methadone, hydrocodone, fentanyl ...
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92
Sequence similarity searches for morphine biosynthesis ...
https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.001001?crawler=true
Exploiting the immunosuppressive, analgesic and highly addictive properties of morphine could increase the success of a bacterial pathogen.
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https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.001001?crawler=true
Exploiting the immunosuppressive, analgesic and highly addictive properties of morphine could increase the success of a bacterial pathogen.
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93
Insights From Laboratory Drug Testing Proficiency Surveys
https://meridian.allenpress.com/aplm/article/144/2/177/433654/Interpretation-and-Utility-of-Drug-of-Abuse
Given the medical, societal, and financial impact of the ongoing opioid ... drugs or drug metabolites that are unknown to the laboratory.
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https://meridian.allenpress.com/aplm/article/144/2/177/433654/Interpretation-and-Utility-of-Drug-of-Abuse
Given the medical, societal, and financial impact of the ongoing opioid ... drugs or drug metabolites that are unknown to the laboratory.
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94
Clinical Pain Management: A Practical Guide
https://books.google.com/books?id=ocV6EAAAQBAJ&pg=PA190&lpg=PA190&dq=morphine+metabolites+clinical+implications&source=bl&ots=njIbqw0jJC&sig=ACfU3U1uC7OnhrxTn38gvEZ5frloLJyt-w&hl=en&sa=X&ved=2ahUKEwi6vIHTycr7AhVoAzQIHa-uDSoQ6AF6BQjCAhAD
Differences in opioid metabolism in the liver also have clinical implications. As an example, morphine and hydromorphone undergo metabolism through ...
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https://books.google.com/books?id=ocV6EAAAQBAJ&pg=PA190&lpg=PA190&dq=morphine+metabolites+clinical+implications&source=bl&ots=njIbqw0jJC&sig=ACfU3U1uC7OnhrxTn38gvEZ5frloLJyt-w&hl=en&sa=X&ved=2ahUKEwi6vIHTycr7AhVoAzQIHa-uDSoQ6AF6BQjCAhAD
Differences in opioid metabolism in the liver also have clinical implications. As an example, morphine and hydromorphone undergo metabolism through ...
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