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Google Keyword Rankings for : how can rnai be used as a treatment
1
Insight Into the Prospects for RNAi Therapy of Cancer - Frontiers
https://www.frontiersin.org/articles/10.3389/fphar.2021.644718/full
Owing to the feature of regulating gene expression, RNAi has been deemed to be the ideal strategy for cancer treatment apart from conventional ...
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https://www.frontiersin.org/articles/10.3389/fphar.2021.644718/full
Owing to the feature of regulating gene expression, RNAi has been deemed to be the ideal strategy for cancer treatment apart from conventional ...
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2
RNAi therapeutics: a potential new class of pharmaceutical ...
https://www.nature.com/articles/nchembio839
Therapeutics based on RNA interference (RNAi) offer a powerful method for rapidly identifying specific and potent inhibitors of disease targets from all ...
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https://www.nature.com/articles/nchembio839
Therapeutics based on RNA interference (RNAi) offer a powerful method for rapidly identifying specific and potent inhibitors of disease targets from all ...
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3
RNAi Therapeutics | How RNA Interference Works
https://www.alnylam.com/our-science/the-science-of-rnai
RNAi therapeutics is an innovative new class of medicines based on RNA interference (RNAi)—a breakthrough discovery in understanding how genes are regulated ...
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https://www.alnylam.com/our-science/the-science-of-rnai
RNAi therapeutics is an innovative new class of medicines based on RNA interference (RNAi)—a breakthrough discovery in understanding how genes are regulated ...
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4
RNAi mechanisms in Huntington's disease therapy: siRNA ...
https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-017-0101-9
RNAi is a potentially curative therapy for HD. A popular line of research employs siRNA or antisense oligonucleotides (ASO) to knock down mutant ...
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https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-017-0101-9
RNAi is a potentially curative therapy for HD. A popular line of research employs siRNA or antisense oligonucleotides (ASO) to knock down mutant ...
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5
RNAi as a treatment for HIV-1 infection - Future Science
https://www.future-science.com/doi/10.2144/000112167
In addition to targeting the virus itself, RNAi-mediated down-regulation of cellular targets that encode receptors required for viral entry also ...
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https://www.future-science.com/doi/10.2144/000112167
In addition to targeting the virus itself, RNAi-mediated down-regulation of cellular targets that encode receptors required for viral entry also ...
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6
RNA Silencing Finds Its Therapeutic Voice
https://www.genengnews.com/insights/rna-silencing-finds-its-therapeutic-voice/
They are finding ways to trigger RNAi so that it suppresses genes associated with disease. In recent years, RNAi therapeutics have been ...
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https://www.genengnews.com/insights/rna-silencing-finds-its-therapeutic-voice/
They are finding ways to trigger RNAi so that it suppresses genes associated with disease. In recent years, RNAi therapeutics have been ...
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7
FDA approves first-ever RNAi therapeutic - C&EN
https://cen.acs.org/pharmaceuticals/drug-discovery/FDA-approves-first-ever-RNAi/96/i33
Twenty years after scientists found that double-stranded RNA can turn off genes, a drug based on the discovery, known as RNA interference, ...
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https://cen.acs.org/pharmaceuticals/drug-discovery/FDA-approves-first-ever-RNAi/96/i33
Twenty years after scientists found that double-stranded RNA can turn off genes, a drug based on the discovery, known as RNA interference, ...
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8
NOVA | scienceNOW | The RNAi Cure - PBS
https://www.pbs.org/wgbh/nova/sciencenow/3210/02-cure.html
So these researchers are exploring ways to use viral vectors—viruses stripped of their harmful genes—to ferry RNA-making molecules into liver cells. It's a ...
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https://www.pbs.org/wgbh/nova/sciencenow/3210/02-cure.html
So these researchers are exploring ways to use viral vectors—viruses stripped of their harmful genes—to ferry RNA-making molecules into liver cells. It's a ...
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9
RNAi Therapeutics - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/medicine-and-dentistry/rnai-therapeutics
The utility of RNAi therapy relies on the effective delivery of the siRNA to the site of protein synthesis. Small-interfering RNA can be administered to the ...
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https://www.sciencedirect.com/topics/medicine-and-dentistry/rnai-therapeutics
The utility of RNAi therapy relies on the effective delivery of the siRNA to the site of protein synthesis. Small-interfering RNA can be administered to the ...
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10
RNAi-based Gene Therapy for Blood Genetic Diseases
https://www.intechopen.com/chapters/49442
RNA interference (RNAi) can be used for gene therapy. It was intensively studied in the past few decades for its potential in the treatment of blood genetic ...
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https://www.intechopen.com/chapters/49442
RNA interference (RNAi) can be used for gene therapy. It was intensively studied in the past few decades for its potential in the treatment of blood genetic ...
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11
Cystic Fibrosis Foundation Therapeutics and Alnylam Initiate ...
https://www.cff.org/press-releases/2005-03/cystic-fibrosis-foundation-therapeutics-and-alnylam-initiate-collaboration
RNAi(TM) to treat a broad range of diseases, including oncology, metabolic, and auto immune Resistant to infection by a specific germ. diseases.
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https://www.cff.org/press-releases/2005-03/cystic-fibrosis-foundation-therapeutics-and-alnylam-initiate-collaboration
RNAi(TM) to treat a broad range of diseases, including oncology, metabolic, and auto immune Resistant to infection by a specific germ. diseases.
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12
Perspectives, issues and solutions in RNAi therapy
https://www.futuremedicine.com/doi/10.2217/nnm-2019-0321
Unlike most other oligonucleotide systems, RNAi relies on a catalytic mechanism and thus requires lower amounts of nucleic acid to be delivered ...
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https://www.futuremedicine.com/doi/10.2217/nnm-2019-0321
Unlike most other oligonucleotide systems, RNAi relies on a catalytic mechanism and thus requires lower amounts of nucleic acid to be delivered ...
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13
RNAi and Gene Therapy: A Mutual Attraction - ASH Publications
https://ashpublications.org/hematology/article/2007/1/473/19175/RNAi-and-Gene-Therapy-A-Mutual-Attraction
The use of RNAi vector libraries should prove extremely useful, as they will facilitate large-scale gene discovery in stem cells. Moreover, RNAi ...
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https://ashpublications.org/hematology/article/2007/1/473/19175/RNAi-and-Gene-Therapy-A-Mutual-Attraction
The use of RNAi vector libraries should prove extremely useful, as they will facilitate large-scale gene discovery in stem cells. Moreover, RNAi ...
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14
siRNA Versus miRNA as Therapeutics for Gene Silencing
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(16)30037-3
Therapeutic approaches based on siRNA involve the introduction of a synthetic siRNA into the target cells to elicit RNA interference (RNAi), thereby inhibiting ...
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https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(16)30037-3
Therapeutic approaches based on siRNA involve the introduction of a synthetic siRNA into the target cells to elicit RNA interference (RNAi), thereby inhibiting ...
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15
Progress and Challenges in RNA Interference Therapy for ...
https://jamanetwork.com/journals/jamaneurology/fullarticle/797655
Importantly, RNAi technology can also be used to ask important basic questions related to HD pathobiology, which in turn may direct more targeted therapies.
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https://jamanetwork.com/journals/jamaneurology/fullarticle/797655
Importantly, RNAi technology can also be used to ask important basic questions related to HD pathobiology, which in turn may direct more targeted therapies.
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16
RNAi Therapeutics: How Likely, How Soon? | PLOS Biology
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0020028
In the lab, RNAi is routinely used to reveal the genetic secrets of development, intracellular signaling, cancer, infection, ...
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https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0020028
In the lab, RNAi is routinely used to reveal the genetic secrets of development, intracellular signaling, cancer, infection, ...
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17
Cardiovascular RNA Interference Therapy - AHA Journals
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.113.301056
It should emphasized that in addition to its direct use to improve the treatment of cardiovascular diseases (by delivery of therapeutic RNAi ...
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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.113.301056
It should emphasized that in addition to its direct use to improve the treatment of cardiovascular diseases (by delivery of therapeutic RNAi ...
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18
RNAi Therapeutics and Applications of MicroRNAs in Cancer ...
https://academic.oup.com/jjco/article/43/6/596/922038
RNA interference-based therapies are proving to be powerful tools for combating various diseases, including cancer. Scientists are researching ...
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https://academic.oup.com/jjco/article/43/6/596/922038
RNA interference-based therapies are proving to be powerful tools for combating various diseases, including cancer. Scientists are researching ...
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19
Gene Therapy and RNAi
https://hudsonalpha.org/gene-therapy-and-rnai/
Researchers have utilized the RNAi pathway to explore the effects of systematically silencing genes. Short synthetic double-stranded RNA ...
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https://hudsonalpha.org/gene-therapy-and-rnai/
Researchers have utilized the RNAi pathway to explore the effects of systematically silencing genes. Short synthetic double-stranded RNA ...
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20
What is RNA Interference? | Ask a Scientist
https://www.thermofisher.com/blog/ask-a-scientist/what-is-rnai/
RNAi refers to a phenomenon where small pieces of RNA can shut down protein translation by binding to messenger RNAs that code for those ...
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https://www.thermofisher.com/blog/ask-a-scientist/what-is-rnai/
RNAi refers to a phenomenon where small pieces of RNA can shut down protein translation by binding to messenger RNAs that code for those ...
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21
Full article: Advances in siRNA delivery in cancer therapy
https://www.tandfonline.com/doi/full/10.1080/21691401.2017.1307210
RNA interference (RNAi)-based therapeutic approaches are under vibrant scrutinisation to seek cancer cure. siRNA suppress expression of the carcinogenic genes ...
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https://www.tandfonline.com/doi/full/10.1080/21691401.2017.1307210
RNA interference (RNAi)-based therapeutic approaches are under vibrant scrutinisation to seek cancer cure. siRNA suppress expression of the carcinogenic genes ...
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22
Therapeutic application of RNAi: is mRNA targeting finally ...
https://www.jci.org/articles/view/34129
With unprecedented speed, RNA interference (RNAi) has advanced from its basic discovery in lower organisms to becoming a powerful genetic ...
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https://www.jci.org/articles/view/34129
With unprecedented speed, RNA interference (RNAi) has advanced from its basic discovery in lower organisms to becoming a powerful genetic ...
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23
RNA Interference (RNAi) - HOPES Stanford
https://hopes.stanford.edu/rna-interference-rnai/
RNA interference (RNAi) is a way to “silence” genes by preventing the formation of the proteins that they code for. A type of gene therapy, it ...
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https://hopes.stanford.edu/rna-interference-rnai/
RNA interference (RNAi) is a way to “silence” genes by preventing the formation of the proteins that they code for. A type of gene therapy, it ...
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24
Therapeutic effect of RNAi gene silencing effective in cancer ...
https://www.sciencedaily.com/releases/2013/02/130211090837.htm
A new study shows for the first time that ribonucleic acid interference (RNAi) is effective in the treatment of cancer patients.
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https://www.sciencedaily.com/releases/2013/02/130211090837.htm
A new study shows for the first time that ribonucleic acid interference (RNAi) is effective in the treatment of cancer patients.
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25
Potential use of RNA interference in cancer therapy
https://www.cambridge.org/core/journals/expert-reviews-in-molecular-medicine/article/potential-use-of-rna-interference-in-cancer-therapy/4C88AF8D876C19FF7F2C2C4DF363EA51
RNAi has become a standard procedure for gene knockdown in cells, which can be used to determine gene function by inhibiting a specific gene and analysing the ...
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https://www.cambridge.org/core/journals/expert-reviews-in-molecular-medicine/article/potential-use-of-rna-interference-in-cancer-therapy/4C88AF8D876C19FF7F2C2C4DF363EA51
RNAi has become a standard procedure for gene knockdown in cells, which can be used to determine gene function by inhibiting a specific gene and analysing the ...
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26
siRNA Therapeutics against Respiratory Viral Infections ...
https://onlinelibrary.wiley.com/doi/10.1002/adhm.202001650
One strategy, however, which could allow to inhibit the replication of virtually any virus is to use RNA interference (RNAi).
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https://onlinelibrary.wiley.com/doi/10.1002/adhm.202001650
One strategy, however, which could allow to inhibit the replication of virtually any virus is to use RNA interference (RNAi).
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27
RNAi Therapeutics - QPS Custom-Built Research Services
https://www.qps.com/whitepaper/rnai-therapeutics/
As with any other pharmacological treatment modality, therapeutic applications of siRNAs also require effective delivery to target cells and tissues. Most of ...
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https://www.qps.com/whitepaper/rnai-therapeutics/
As with any other pharmacological treatment modality, therapeutic applications of siRNAs also require effective delivery to target cells and tissues. Most of ...
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28
RNA interference (RNAi): by Nature Video - YouTube
https://www.youtube.com/watch?v=cK-OGB1_ELE
nature video
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https://www.youtube.com/watch?v=cK-OGB1_ELE
nature video
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29
RNAi Therapeutics | Transfection Reagents | Cell Lines, In Vivo
https://altogen.com/transfection-resource/rnai-therapeutics/
RNAi Therapeutics refers to the use of RNAi technology to treat genetic diseases and certain disorders. By changing the protein expression in cells, some ...
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https://altogen.com/transfection-resource/rnai-therapeutics/
RNAi Therapeutics refers to the use of RNAi technology to treat genetic diseases and certain disorders. By changing the protein expression in cells, some ...
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30
RNA interference therapeutics for cancer: Challenges and ...
https://www.spandidos-publications.com/10.3892/mmr.2012.871/download
detect potent and specific RNAi in commonly used mammalian ... more potent and effective way to treat cancer and it would also.
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https://www.spandidos-publications.com/10.3892/mmr.2012.871/download
detect potent and specific RNAi in commonly used mammalian ... more potent and effective way to treat cancer and it would also.
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31
RNAi Therapies - Huntington's Disease News
https://huntingtonsdiseasenews.com/rnai-therapies/
Gene silencing by RNA interference (RNAi) is a therapeutic approach for the treatment of Huntington's disease that is currently in development.
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https://huntingtonsdiseasenews.com/rnai-therapies/
Gene silencing by RNA interference (RNAi) is a therapeutic approach for the treatment of Huntington's disease that is currently in development.
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32
What is RNAi and how does it work? | Proclinical Blogs
https://www.proclinical.com/blogs/2021-1/what-is-rnai-and-how-does-it-work
RNAi drug delivery is now widely used for treating infectious diseases, chronic metabolic disorders, cardiovascular, neurological, urological, ...
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https://www.proclinical.com/blogs/2021-1/what-is-rnai-and-how-does-it-work
RNAi drug delivery is now widely used for treating infectious diseases, chronic metabolic disorders, cardiovascular, neurological, urological, ...
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33
RNAi‐based therapeutics–current status, challenges and ...
https://www.embopress.org/doi/10.1002/emmm.200900023
The field of applied RNAi therapeutics has moved very quickly from lab to bedside. The RNAi approach has been widely used for drug development and several phase ...
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https://www.embopress.org/doi/10.1002/emmm.200900023
The field of applied RNAi therapeutics has moved very quickly from lab to bedside. The RNAi approach has been widely used for drug development and several phase ...
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34
RNA Interference - Muscular Dystrophy News
https://musculardystrophynews.com/rna-interference/
RNAi is a method of silencing gene expression, and has been used recently in experimental gene therapies to treat certain types of muscular ...
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https://musculardystrophynews.com/rna-interference/
RNAi is a method of silencing gene expression, and has been used recently in experimental gene therapies to treat certain types of muscular ...
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35
Silence Therapeutics
https://silence-therapeutics.com/home/default.aspx
The natural mechanism of RNA enables the design and use of synthetic siRNAs that aim to treat diseases by degrading the mRNAs which encode instructions for ...
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https://silence-therapeutics.com/home/default.aspx
The natural mechanism of RNA enables the design and use of synthetic siRNAs that aim to treat diseases by degrading the mRNAs which encode instructions for ...
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36
What is RNAi - RNAi Biology - UMass Medical School
https://www.umassmed.edu/rti/biology/rna/how-rnai-works/
Two decades ago, Andrew Fire and the RTI's Craig Mello discovered how to use RNA to find and regulate specific genes. It's known as RNA interference (or ...
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https://www.umassmed.edu/rti/biology/rna/how-rnai-works/
Two decades ago, Andrew Fire and the RTI's Craig Mello discovered how to use RNA to find and regulate specific genes. It's known as RNA interference (or ...
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37
Harnessing RNAi-based nanomedicines for therapeutic gene ...
https://www.pnas.org/doi/10.1073/pnas.1519273113
Small interfering RNAs (siRNAs) that manipulate gene expression in leukocytes could be used to treat blood cancers. However, the lack of strategies for ...
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https://www.pnas.org/doi/10.1073/pnas.1519273113
Small interfering RNAs (siRNAs) that manipulate gene expression in leukocytes could be used to treat blood cancers. However, the lack of strategies for ...
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38
RNAi-based therapies for the treatment of HIV
https://www.europeanpharmaceuticalreview.com/article/3122/rnai-based-therapies-for-the-treatment-of-hiv/
The therapeutic application of RNAi for the treatment of HIV has followed two distinct strategies. RNAi can be elicited by using synthetic ...
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https://www.europeanpharmaceuticalreview.com/article/3122/rnai-based-therapies-for-the-treatment-of-hiv/
The therapeutic application of RNAi for the treatment of HIV has followed two distinct strategies. RNAi can be elicited by using synthetic ...
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39
RNAi Therapies: Drugging the Undruggable - Science
https://www.science.org/doi/10.1126/scitranslmed.3008362
In addition to targeting a single gene, RNAi technology is ideally suited for achieving coextinction or therapeutic synergy in cancer treatment. Such a strategy ...
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https://www.science.org/doi/10.1126/scitranslmed.3008362
In addition to targeting a single gene, RNAi technology is ideally suited for achieving coextinction or therapeutic synergy in cancer treatment. Such a strategy ...
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40
RNA interference - Wikipedia
https://en.wikipedia.org/wiki/RNA_interference
RNAi may be used for large-scale screens that systematically shut down each gene (and the subsequent proteins it codes for) in the cell, which can help to ...
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https://en.wikipedia.org/wiki/RNA_interference
RNAi may be used for large-scale screens that systematically shut down each gene (and the subsequent proteins it codes for) in the cell, which can help to ...
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41
Clinical translation of RNAi-based treatments for respiratory ...
https://link.springer.com/article/10.1007/s13346-012-0098-7
The ability to harness the RNA interference (RNAi) mechanism as a potential potent therapeutic has attracted great interest from academia ...
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https://link.springer.com/article/10.1007/s13346-012-0098-7
The ability to harness the RNA interference (RNAi) mechanism as a potential potent therapeutic has attracted great interest from academia ...
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42
Recent Advances in the Development of Exogenous dsRNA ...
https://www.mdpi.com/1420-3049/26/3/701
The treatment of tumor diseases by RNA interference-mediated therapies also seems to be a very promising approach, as it can be used to selectively knock ...
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https://www.mdpi.com/1420-3049/26/3/701
The treatment of tumor diseases by RNA interference-mediated therapies also seems to be a very promising approach, as it can be used to selectively knock ...
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43
RNAi Therapy Development Service - Creative Biolabs
https://www.creative-biolabs.com/gene-therapy/gene-therapy-solutions.htm
For Research Use Only. Do NOT use in humans or animals. RNA interference (RNAi) is a process that has been found in all living cells.
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https://www.creative-biolabs.com/gene-therapy/gene-therapy-solutions.htm
For Research Use Only. Do NOT use in humans or animals. RNA interference (RNAi) is a process that has been found in all living cells.
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44
NOVA scienceNOW | RNAi Therapy | PBS LearningMedia
https://www.pbslearningmedia.org/resource/lsps07.sci.life.gen.rnaitherapy/rnai-therapy/
› resource › rnai-the...
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https://www.pbslearningmedia.org/resource/lsps07.sci.life.gen.rnaitherapy/rnai-therapy/
› resource › rnai-the...
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45
Therapeutic Triggers of RNAi - Gene Therapy Network
https://genetherapynetwork.com/gene-replacement/gene-inhibition-therapy/therapeutic-triggers-of-rnai/
Because they have partial complementarity to the target mRNA, artificial microRNAs can induce gene inhibition via translational repression, mRNA degradation, or ...
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https://genetherapynetwork.com/gene-replacement/gene-inhibition-therapy/therapeutic-triggers-of-rnai/
Because they have partial complementarity to the target mRNA, artificial microRNAs can induce gene inhibition via translational repression, mRNA degradation, or ...
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46
RNA interference: A new alternative for rheumatic diseases ...
https://www.scielo.br/j/rbr/a/QMNDF9KH6tFqZhXfz6zjfGs/?format=pdf&lang=en
The use of RNAi as a tool for gene therapy has been extensively studied, especially in ... In fungi, the deletion of genes related to RNAi pathway causes.
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https://www.scielo.br/j/rbr/a/QMNDF9KH6tFqZhXfz6zjfGs/?format=pdf&lang=en
The use of RNAi as a tool for gene therapy has been extensively studied, especially in ... In fungi, the deletion of genes related to RNAi pathway causes.
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47
The future of personalized cancer treatment: An entirely new ...
https://phys.org/news/2009-05-future-personalized-cancer-treatment-rnai.html
This allows the resultant fusion protein to enter the cell and deliver the siRNA into the cytoplasm where it specifically targets mRNAs from ...
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https://phys.org/news/2009-05-future-personalized-cancer-treatment-rnai.html
This allows the resultant fusion protein to enter the cell and deliver the siRNA into the cytoplasm where it specifically targets mRNAs from ...
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48
RNA Interference - Silenseed
https://www.silenseed.com/science-technology/rna-interference/
Ability to treat a broad range of diseases. siRNAs have the ability to silence virtually any gene to suppress the production of the related cancer-causing ...
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https://www.silenseed.com/science-technology/rna-interference/
Ability to treat a broad range of diseases. siRNAs have the ability to silence virtually any gene to suppress the production of the related cancer-causing ...
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49
RNAi Agents: Drug Class, Uses, Side Effects, Drug Names
https://www.rxlist.com/rnai_agents/drug-class.htm
RNA interference (RNAi) agents are a collection of small RNA molecules that are used to treat rare genetic disorders. These drugs work by inducing ...
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https://www.rxlist.com/rnai_agents/drug-class.htm
RNA interference (RNAi) agents are a collection of small RNA molecules that are used to treat rare genetic disorders. These drugs work by inducing ...
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50
RNA-based therapies: two types explained
https://www.genomicseducation.hee.nhs.uk/blog/rna-based-therapies-two-types-explained/
What are RNA therapies and how are they used? We compare the two licensed types – antisense and RNA interference – to find out more.
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https://www.genomicseducation.hee.nhs.uk/blog/rna-based-therapies-two-types-explained/
What are RNA therapies and how are they used? We compare the two licensed types – antisense and RNA interference – to find out more.
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51
siRNA - Applications - Horizon Discovery
https://horizondiscovery.com/en/applications/rnai/sirna-applications
siRNA screens have been used to identify novel pathways16 and have had significant impact in validating targets for a number of cellular processes and diseases ...
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https://horizondiscovery.com/en/applications/rnai/sirna-applications
siRNA screens have been used to identify novel pathways16 and have had significant impact in validating targets for a number of cellular processes and diseases ...
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52
Therapeutic RNAi Development: Targeted siRNA, qPCR Assays
https://altogenlabs.com/pre-clinical-research-services/therapeutic-rnai-development-targeted-sirna-qpcr-assays/
In mammalian cells, RNAi can be used to reduce the expression of specific genes in a sequence-specific approach, and it is a powerful method of identifying drug ...
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https://altogenlabs.com/pre-clinical-research-services/therapeutic-rnai-development-targeted-sirna-qpcr-assays/
In mammalian cells, RNAi can be used to reduce the expression of specific genes in a sequence-specific approach, and it is a powerful method of identifying drug ...
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53
siRNA: A Potential Tool for Future Breast Cancer Therapy?
https://unclineberger.org/peroulab/wp-content/uploads/sites/1008/2019/06/Sept-4-RNAi-Critical-Reviews-Storvold-Oncogenesis-2006.pdf
In this article, we discuss the RNAi approach, and the use of siRNAs for cancer target validation and future breast cancer therapy. II. RNA Interference.
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https://unclineberger.org/peroulab/wp-content/uploads/sites/1008/2019/06/Sept-4-RNAi-Critical-Reviews-Storvold-Oncogenesis-2006.pdf
In this article, we discuss the RNAi approach, and the use of siRNAs for cancer target validation and future breast cancer therapy. II. RNA Interference.
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54
Safety and Efficacy of RNAi Therapy for Transthyretin ...
https://www.nejm.org/doi/full/10.1056/nejmoa1208760
by T Coelho · 2013 · Cited by 898 —
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https://www.nejm.org/doi/full/10.1056/nejmoa1208760
by T Coelho · 2013 · Cited by 898 —
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55
Knockout punch: the promise of RNAi - Whitehead Institute
https://wi.mit.edu/news/knockout-punch-promise-rnai
Several classes of RNAi-based drugs are at advanced stages of development. One—a treatment for age-related macular degeneration (AMD) of the eye—is in Phase 1 ...
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https://wi.mit.edu/news/knockout-punch-promise-rnai
Several classes of RNAi-based drugs are at advanced stages of development. One—a treatment for age-related macular degeneration (AMD) of the eye—is in Phase 1 ...
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56
Therapy for Dominant Inherited Diseases by Allele-Specific ...
https://www.eurekaselect.com/node/133888/4
This property was used to develop a particular therapeutic strategy called “allele-specific-RNA interference” devoted to silence the mutated allele of genes ...
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https://www.eurekaselect.com/node/133888/4
This property was used to develop a particular therapeutic strategy called “allele-specific-RNA interference” devoted to silence the mutated allele of genes ...
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57
RNA Interference-Based Cancer Drugs: The Roadblocks, and ...
https://www.liebertpub.com/doi/10.1089/nat.2018.0762
The results from the Phase I clinical trials in anticancer RNAi demonstrated that it is possible to deliver therapeutic siRNA to human tumors ...
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https://www.liebertpub.com/doi/10.1089/nat.2018.0762
The results from the Phase I clinical trials in anticancer RNAi demonstrated that it is possible to deliver therapeutic siRNA to human tumors ...
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58
What is RNA Interference? - News Medical
https://www.news-medical.net/life-sciences/What-is-RNA-Interference.aspx
Furthermore, RNAi can be utilized for large-scale screening repressing individual genes to help elucidate mechanisms underpinning key cellular processes in ...
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https://www.news-medical.net/life-sciences/What-is-RNA-Interference.aspx
Furthermore, RNAi can be utilized for large-scale screening repressing individual genes to help elucidate mechanisms underpinning key cellular processes in ...
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59
RNA Interference | Amgen
https://www.amgen.com/stories/2018/08/the-shape-of-drugs-to-come/rna-interference
RNA interference (RNAi) is a technology that works by preventing cells from making a specific protein that contributes to disease. Also known as gene silencing, ...
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https://www.amgen.com/stories/2018/08/the-shape-of-drugs-to-come/rna-interference
RNA interference (RNAi) is a technology that works by preventing cells from making a specific protein that contributes to disease. Also known as gene silencing, ...
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60
RNAi could hold promise in the treatment of HIV - The Lancet
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(02)08853-0/fulltext
RNAi works by silencing gene expression after the messenger RNA (mRNA) has been transcribed from the host cell's DNA template. Short, double- ...
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https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(02)08853-0/fulltext
RNAi works by silencing gene expression after the messenger RNA (mRNA) has been transcribed from the host cell's DNA template. Short, double- ...
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61
RNA interference-based therapies for the control of atherosc...
https://journals.lww.com/co-cardiology/Fulltext/2022/07000/RNA_interference_based_therapies_for_the_control.10.aspx
RNAi technology, targeted to treat vascular inflammation and lipid metabolism, provides an effective therapeutic tool against ASCVDs. The first mRNA targeted ...
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https://journals.lww.com/co-cardiology/Fulltext/2022/07000/RNA_interference_based_therapies_for_the_control.10.aspx
RNAi technology, targeted to treat vascular inflammation and lipid metabolism, provides an effective therapeutic tool against ASCVDs. The first mRNA targeted ...
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62
Pocket K No. 34: RNAi for Crop Improvement - ISAAA
https://www.isaaa.org/resources/publications/pocketk/34/default.asp
In addition to its roles in regulating gene expression, RNAi is used as an immune response to infection5 and as a natural defense mechanism against molecular ...
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https://www.isaaa.org/resources/publications/pocketk/34/default.asp
In addition to its roles in regulating gene expression, RNAi is used as an immune response to infection5 and as a natural defense mechanism against molecular ...
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63
(PDF) RNA interference; A tool for treatment of human diseases
https://www.researchgate.net/publication/304474958_RNA_interference_A_tool_for_treatment_of_human_diseases
In recent era, RNAi is directly used in therapy of various infectious and non-infectious diseases. Variety of human diseases like cancer, viral ...
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https://www.researchgate.net/publication/304474958_RNA_interference_A_tool_for_treatment_of_human_diseases
In recent era, RNAi is directly used in therapy of various infectious and non-infectious diseases. Variety of human diseases like cancer, viral ...
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64
What is RNAi and siRNA? - GeneLink
https://www.genelink.com/sirna/rnaiwhatis.asp
Recent advances in molecular biology have shown that gene expression can be effectively silenced in a highly specific manner through the addition of double ...
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https://www.genelink.com/sirna/rnaiwhatis.asp
Recent advances in molecular biology have shown that gene expression can be effectively silenced in a highly specific manner through the addition of double ...
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65
RNAi vs. CRISPR: Guide to Selecting the Best Gene Silencing ...
https://www.synthego.com/blog/rnai-vs-crispr-guide
RNAi and CRISPR interrogate gene function by blocking gene expression and analyzing its effect on phenotype. RNAi silences genes by ...
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https://www.synthego.com/blog/rnai-vs-crispr-guide
RNAi and CRISPR interrogate gene function by blocking gene expression and analyzing its effect on phenotype. RNAi silences genes by ...
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66
RNA interference | biochemistry | Britannica
https://www.britannica.com/science/RNA-interference
RNAi treatments for macular degeneration involve the injection of “naked RNA” into the eye. The term naked RNA is used to distinguish this ...
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https://www.britannica.com/science/RNA-interference
RNAi treatments for macular degeneration involve the injection of “naked RNA” into the eye. The term naked RNA is used to distinguish this ...
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67
An Overview of RNAi Therapy - Verywell Health
https://www.verywellhealth.com/an-overview-of-rnai-therapy-4175809
RNA interference (RNAi) therapy is a type of biotechnology that targets and alters genes. It is being explored to treat a number of different conditions, ...
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https://www.verywellhealth.com/an-overview-of-rnai-therapy-4175809
RNA interference (RNAi) therapy is a type of biotechnology that targets and alters genes. It is being explored to treat a number of different conditions, ...
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68
Can Using RNA Simplify Gene Therapy Development?
https://www.biopharminternational.com/view/can-using-rna-simplify-gene-therapy-development
The first type includes RNA interference (RNAi) and antisense therapies, which in effect silence the expression of specific genes that are ...
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https://www.biopharminternational.com/view/can-using-rna-simplify-gene-therapy-development
The first type includes RNA interference (RNAi) and antisense therapies, which in effect silence the expression of specific genes that are ...
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69
siRNA FAQ - Sigma-Aldrich
https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/gene-expression-and-silencing/sirna-faq
How long does siRNA silence a gene? Gene silencing resulting from siRNA can be assessed as early as 24 hours post-transfection. The effect most often will last ...
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https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/gene-expression-and-silencing/sirna-faq
How long does siRNA silence a gene? Gene silencing resulting from siRNA can be assessed as early as 24 hours post-transfection. The effect most often will last ...
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70
First-in-Humans Trial of an RNA Interference Therapeutic ...
https://aacrjournals.org/cancerdiscovery/article/3/4/406/3986/First-in-Humans-Trial-of-an-RNA-Interference
The use of siRNAs to specifically silence genes involved in disease pathogenesis holds promise for the development of a new and far-reaching class of ...
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https://aacrjournals.org/cancerdiscovery/article/3/4/406/3986/First-in-Humans-Trial-of-an-RNA-Interference
The use of siRNAs to specifically silence genes involved in disease pathogenesis holds promise for the development of a new and far-reaching class of ...
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71
RNA Interference | The American Biology Teacher
https://online.ucpress.edu/abt/article/76/6/373/3263/RNA-InterferenceAn-Instant-Update-on-the-Mechanism
Using RNA interference to treat diseases is theoretically viable because RNA interference is a natural process and double-stranded RNA is an ...
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https://online.ucpress.edu/abt/article/76/6/373/3263/RNA-InterferenceAn-Instant-Update-on-the-Mechanism
Using RNA interference to treat diseases is theoretically viable because RNA interference is a natural process and double-stranded RNA is an ...
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72
US approves first RNA interference drug - Chemistry World
https://www.chemistryworld.com/news/us-approves-first-rna-interference-drug/3009385.article
The first therapy based on RNA interference (RNAi) gene silencing has been approved by the US Food and Drug Administration (FDA). Alnylam ...
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https://www.chemistryworld.com/news/us-approves-first-rna-interference-drug/3009385.article
The first therapy based on RNA interference (RNAi) gene silencing has been approved by the US Food and Drug Administration (FDA). Alnylam ...
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73
The coming of age story of RNAi technology - Labiotech
https://www.labiotech.eu/in-depth/rnai-new-developments/
The conventional method of treatment has been to target the faulty protein, and more recently to target the gene itself via gene therapy. It ...
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https://www.labiotech.eu/in-depth/rnai-new-developments/
The conventional method of treatment has been to target the faulty protein, and more recently to target the gene itself via gene therapy. It ...
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74
Market of siRNAs Poised to Expand Beyond 3 Currently ...
https://www.ajmc.com/view/market-of-sirnas-poised-to-expand-beyond-3-currently-approved-drugs
Creating siRNA-based drugs has been a 20-year process, but in 2018, the FDA approved patisiran, the first siRNA, to treat hereditary ...
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https://www.ajmc.com/view/market-of-sirnas-poised-to-expand-beyond-3-currently-approved-drugs
Creating siRNA-based drugs has been a 20-year process, but in 2018, the FDA approved patisiran, the first siRNA, to treat hereditary ...
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75
Therapeutic Applications of RNAi for Silencing Virus Replication
https://experiments.springernature.com/articles/10.1007/978-1-60327-295-7_4
The RNAi machinery is believed to be expressed in all eukaryotic cells and has been shown to regulate host gene expression. Given this ability, RNAi silencing ...
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https://experiments.springernature.com/articles/10.1007/978-1-60327-295-7_4
The RNAi machinery is believed to be expressed in all eukaryotic cells and has been shown to regulate host gene expression. Given this ability, RNAi silencing ...
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76
The future of HIV infection: gene therapy and RNA interference
https://www.elsevier.es/es-revista-enfermedades-infecciosas-microbiologia-clinica-28-articulo-the-future-of-hiv-infection-13082744
Based on the potency, specificity and physiology of RNAi to silence gene expression, much is expected from its use as a therapeutic tool.
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https://www.elsevier.es/es-revista-enfermedades-infecciosas-microbiologia-clinica-28-articulo-the-future-of-hiv-infection-13082744
Based on the potency, specificity and physiology of RNAi to silence gene expression, much is expected from its use as a therapeutic tool.
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77
Science - Arrowhead Pharmaceuticals, Inc.
https://arrowheadpharma.com/science/
RNAi refers to a natural cellular mechanism whereby short oligonucleotide molecules called RNAi triggers silence gene expression and regulate the production of ...
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https://arrowheadpharma.com/science/
RNAi refers to a natural cellular mechanism whereby short oligonucleotide molecules called RNAi triggers silence gene expression and regulate the production of ...
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78
RNA interference - A technology platform for target validation ...
https://www.ddw-online.com/rna-interference-a-technology-platform-for-target-validation-drug-discovery-and-therapeutic-development-1210-200308/
The RNAi approach has been applied to study the function of several essential genes involved in cell growth, cell cycle, cytoskeleton, ...
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https://www.ddw-online.com/rna-interference-a-technology-platform-for-target-validation-drug-discovery-and-therapeutic-development-1210-200308/
The RNAi approach has been applied to study the function of several essential genes involved in cell growth, cell cycle, cytoskeleton, ...
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79
RNA silencing - Sylentis
https://sylentis.com/rna-silencing/
RNAi drugs use the cellular machinery in the cytoplasm to silence messenger RNA (mRNA), which are molecular precursors of proteins, and thus, without affecting ...
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https://sylentis.com/rna-silencing/
RNAi drugs use the cellular machinery in the cytoplasm to silence messenger RNA (mRNA), which are molecular precursors of proteins, and thus, without affecting ...
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80
How siRNA and miRNA Molecules Inhibit mRNAs - RNAi
https://study.com/learn/lesson/sirna-molecules-characteristics-function.html
siRNA is used to degrade mRNA and silence genes. siRNA vs miRNA. In addition to siRNAs, RNA interference also employs miRNAs. The biggest ...
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https://study.com/learn/lesson/sirna-molecules-characteristics-function.html
siRNA is used to degrade mRNA and silence genes. siRNA vs miRNA. In addition to siRNAs, RNA interference also employs miRNAs. The biggest ...
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81
10 RNA-Based Therapies - Cleveland Clinic Innovations
https://innovations.clevelandclinic.org/Programs/Top-10-Medical-Innovations/Top-10-for-2019/10-RNA-Based-Therapies
RNA interference therapy is currently being explored for use in cancer and neurological diseases. Alzheimer's disease is poised to be the most important ...
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https://innovations.clevelandclinic.org/Programs/Top-10-Medical-Innovations/Top-10-for-2019/10-RNA-Based-Therapies
RNA interference therapy is currently being explored for use in cancer and neurological diseases. Alzheimer's disease is poised to be the most important ...
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82
8. Gene Silencing Methods: CRISPR vs. RNAi vs. TALEN
https://old.abmgood.com/marketing/knowledge_base/Gene-Silencing-CRISPR-TALEN-RNAi.php
Because it uses host machinery to achieve silencing, RNAi has the simplest experimental set up and siRNA treatment can cause significant gene repression in only ...
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https://old.abmgood.com/marketing/knowledge_base/Gene-Silencing-CRISPR-TALEN-RNAi.php
Because it uses host machinery to achieve silencing, RNAi has the simplest experimental set up and siRNA treatment can cause significant gene repression in only ...
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83
Vector-based RNAi technology - GenScript
https://www.genscript.com/siRNA_technology.html
Next, the single-stranded siRNAs guide the RISC complex to the target mRNAs for destruction, causing RNA interference. Depending on the amount of siRNA ...
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https://www.genscript.com/siRNA_technology.html
Next, the single-stranded siRNAs guide the RISC complex to the target mRNAs for destruction, causing RNA interference. Depending on the amount of siRNA ...
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84
Moderna: Pioneering mRNA technology
https://www.modernatx.com/en-US/
mRNA medicines fight diseases in a different way than traditional medicine by prompting your immune system to create the tools to treat or prevent disease.
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https://www.modernatx.com/en-US/
mRNA medicines fight diseases in a different way than traditional medicine by prompting your immune system to create the tools to treat or prevent disease.
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85
RNA Interference (RNAi): A New Threat to Our Food?
https://www.planetnatural.com/rna-interference/
This technology, if it works, would kill the worm by introducing the genetic interference component into the worm when it begins to consume ...
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https://www.planetnatural.com/rna-interference/
This technology, if it works, would kill the worm by introducing the genetic interference component into the worm when it begins to consume ...
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86
Science | siRNAgen Therapeutic
https://www.sirnagen.com/science
These small fragments, referred to as small interfering RNAs (siRNA), constitute the RNA-induced silencing complex (RISC) and leads to the cleavage of the ...
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https://www.sirnagen.com/science
These small fragments, referred to as small interfering RNAs (siRNA), constitute the RNA-induced silencing complex (RISC) and leads to the cleavage of the ...
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87
RNA therapy - Gene Vision
https://gene.vision/knowledge-base/rna-therapy/
Hence, RNA therapy is designed to correct the mutation in the RNA of the patient, which means that the mutation is not passed on, and correct ...
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https://gene.vision/knowledge-base/rna-therapy/
Hence, RNA therapy is designed to correct the mutation in the RNA of the patient, which means that the mutation is not passed on, and correct ...
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88
RNAi Therapeutics Market is Likely to Set for Rapid Expansion
https://www.openpr.com/news/2819371/rnai-therapeutics-market-is-likely-to-set-for-rapid-expansion
These RNAi are used to silence particular genes that are responsible for diseases. At present, the awareness about RNAi is increasing due to its ...
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https://www.openpr.com/news/2819371/rnai-therapeutics-market-is-likely-to-set-for-rapid-expansion
These RNAi are used to silence particular genes that are responsible for diseases. At present, the awareness about RNAi is increasing due to its ...
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89
RNA Interference (RNAi) Therapeutics Landscape to Evolve ...
https://www.digitaljournal.com/pr/rna-interference-rnai-therapeutics-landscape-to-evolve-substantially-with-active-participation-of-20-key-pharma-and-biotech-companies-in-the-market
It accesses the different RNA Interference therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development. It ...
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https://www.digitaljournal.com/pr/rna-interference-rnai-therapeutics-landscape-to-evolve-substantially-with-active-participation-of-20-key-pharma-and-biotech-companies-in-the-market
It accesses the different RNA Interference therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development. It ...
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90
OliX Pharmaceuticals Publishes Preclinical Research ...
https://www.businesswire.com/news/home/20221122005053/en/OliX-Pharmaceuticals-Publishes-Preclinical-Research-Demonstrating-OLX104C%E2%80%99s-Potential-as-an-Effective-Treatment-for-Hair-Loss
The paper “Efficacy of Asymmetric siRNA Targeting Androgen Receptor for the Treatment of Androgenetic Alopecia” is based on the preclinical ...
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https://www.businesswire.com/news/home/20221122005053/en/OliX-Pharmaceuticals-Publishes-Preclinical-Research-Demonstrating-OLX104C%E2%80%99s-Potential-as-an-Effective-Treatment-for-Hair-Loss
The paper “Efficacy of Asymmetric siRNA Targeting Androgen Receptor for the Treatment of Androgenetic Alopecia” is based on the preclinical ...
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91
RNA Interference (RNAi) – Nature Reviews Genetics
http://naturedocumentaries.org/6018/rna-interference-rnai-nature-reviews-genetics/
RNA interference (RNAi) is a process used by wide range of organisms to regulate the activity of genes. This animation summarizes how RNAi ...
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http://naturedocumentaries.org/6018/rna-interference-rnai-nature-reviews-genetics/
RNA interference (RNAi) is a process used by wide range of organisms to regulate the activity of genes. This animation summarizes how RNAi ...
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92
Sirnagen CosmeRNA for Hair Loss: Releasing in 2023
https://www.hairlosscure2020.com/cosmerna-for-hair-loss-from-sirnagen/
A new siRNA based topical hair loss product called CosmeRNA will be ... is working on a hair loss cure involving RNA interference (RNAi) via ...
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https://www.hairlosscure2020.com/cosmerna-for-hair-loss-from-sirnagen/
A new siRNA based topical hair loss product called CosmeRNA will be ... is working on a hair loss cure involving RNA interference (RNAi) via ...
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93
Articles with Alnylam Pharmaceuticals - BioSpace
https://www.biospace.com/employer/542164/alnylam-pharmaceuticals/
jobs with Alnylam Pharmaceuticals to view and apply for now with BioSpace. ... an investigational RNAi therapeutic in development for the treatment of ...
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https://www.biospace.com/employer/542164/alnylam-pharmaceuticals/
jobs with Alnylam Pharmaceuticals to view and apply for now with BioSpace. ... an investigational RNAi therapeutic in development for the treatment of ...
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94
last - Green Olives Labs – …
https://school.greenoliveslabs.com/1hnewt/rna-companies-boston.html
It is well known that messenger RNA was used to quickly develop effective ... company committed to more effectively treating cancer using RNA therapeutics .
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https://school.greenoliveslabs.com/1hnewt/rna-companies-boston.html
It is well known that messenger RNA was used to quickly develop effective ... company committed to more effectively treating cancer using RNA therapeutics .
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95
China RNA Activation Venture Ractigen Looks To Clinic For ...
https://scrip.pharmaintelligence.informa.com/SC147423/China-RNA-Activation-Venture-Ractigen-Looks-To-Clinic-For-Validation
After more than 10 years of drug hunting in the shadow of RNA interference (RNAi), Long-Cheng Li, co-founder and CEO of the Chinese biotech ...
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https://scrip.pharmaintelligence.informa.com/SC147423/China-RNA-Activation-Venture-Ractigen-Looks-To-Clinic-For-Validation
After more than 10 years of drug hunting in the shadow of RNA interference (RNAi), Long-Cheng Li, co-founder and CEO of the Chinese biotech ...
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96
Leading companies in microneedles for transdermal drug ...
https://www.pharmaceutical-technology.com/data-insights/innovators-microneedles-for-transdermal-drug-delivery-pharmaceutical/
Microneedles are sterilised micron-sized, minimally invasive novel drug delivery needles used to administer therapeutic agents.
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https://www.pharmaceutical-technology.com/data-insights/innovators-microneedles-for-transdermal-drug-delivery-pharmaceutical/
Microneedles are sterilised micron-sized, minimally invasive novel drug delivery needles used to administer therapeutic agents.
→ Check Latest Keyword Rankings ←
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