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1
https://www.washington.edu/news/2012/11/08/extra-chromosome-21-removed-from-down-syndrome-cell-line/
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2
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3
https://blogs.biomedcentral.com/on-medicine/2017/12/04/crisprcas9-gene-editing-can-be-used-to-eliminate-entire-chromosomes-a-qa/
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4
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5
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6
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7
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8
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9
https://www.nature.com/articles/nature.2013.13406
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10
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11
https://www.science.org/content/article/forget-single-genes-crispr-now-cuts-and-splices-whole-chromosomes
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12
https://www.ucsf.edu/news/2014/01/111076/nature-study-discovers-chromosome-therapy-correct-severe-chromosome-defect
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13
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14
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16
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19
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20
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21
https://www.statnews.com/2022/01/06/provocative-new-findings-suggest-surprising-cause-of-down-syndrome/
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22
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23
https://www.theguardian.com/science/2013/jul/17/downs-syndrome-cells-fixed-chromosome-therapy
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24
https://www.cuimc.columbia.edu/news/study-identifies-pitfall-correcting-mutations-human-embryos-crispr
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25
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26
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27
https://www.cell.com/cell/pdf/S0092-8674(20)31389-1.pdf
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28
https://www.webmd.com/children/understanding-down-syndrome-basics
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29
https://www.frontiersin.org/articles/10.3389/fped.2021.592571/full
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30
https://link.springer.com/article/10.1007/s00335-021-09930-z
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31
https://www.dailyuw.com/news/removal-of-extra-chromosome-21-promising-for-future-research/article_737a841e-21b3-5201-96b7-10e1a843dbfc.html
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32
https://www.nytimes.com/2020/10/31/health/crispr-genetics-embryos.html
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33
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34
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35
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36
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37
https://www.genome.gov/news/news-release/Sequencing-all-24-human-chromosomes-uncovers-rare-disorders
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38
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39
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40
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41
https://en.wikipedia.org/wiki/Deletion_(genetics)
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42
https://www.healio.com/hematology-oncology/learn-genomics/genomics-primer/genetic-alterations
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43
https://www.pnas.org/doi/10.1073/pnas.1918859117
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44
https://www.quora.com/What-will-happen-if-a-chromosome-is-removed-from-a-cell
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45
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48
https://www.rarechromo.org/media/information/Chromosome%20%206/6q%20deletions%20from%206q26%20and%206q27%20FTNW.pdf
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49
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50
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51
https://www.wrh.ox.ac.uk/news/non-invasive-test-for-chromosome-abnormalities-in-womens-eggs
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53
https://www.verywellfamily.com/chromosomal-abnormality-2371605
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54
https://www.fda.gov/consumers/consumer-updates/how-gene-therapy-can-cure-or-treat-diseases
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55
https://www.ksat.com/health/2014/11/17/stem-cells-to-repair-broken-chromosomes-medicines-next-big-thing/
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56
http://www.intellectualdisability.info/conditions-associated-with-intellectual-disability/articles/downs-syndrome
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57
https://erc.bioscientifica.com/view/journals/erc/24/9/ERC-17-0187.xml
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58
https://theconversation.com/the-y-chromosome-is-disappearing-so-what-will-happen-to-men-90125
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59
https://sitn.hms.harvard.edu/flash/2014/crispr-a-game-changing-genetic-engineering-technique/
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60
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63
https://journals.asm.org/doi/10.1128/MCB.00377-09
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64
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65
https://www.fpwr.org/genetic-therapy-for-prader-willi-syndrome
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66
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https://www.livescience.com/y-chromosome-dying.html
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https://www.mayoclinic.org/diseases-conditions/klinefelter-syndrome/diagnosis-treatment/drc-20353954
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70
https://www.geneticsandsociety.org/internal-content/what-human-gene-editing
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71
https://www.stanfordchildrens.org/en/topic/default?id=down-syndrome-trisomy-21-90-P02356
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72
https://phys.org/news/2022-08-sustainable-chromosome-mice.html
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74
https://www.newscientist.com/article/dn16934-girl-with-y-chromosome-sheds-light-on-maleness/
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75
https://www.irishtimes.com/news/health/scientists-find-way-to-switch-off-chromosome-that-causes-down-syndrome-1.1467559
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76
https://www.healthline.com/health/xyy-syndrome
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https://www.embopress.org/doi/10.15252/emmm.201607284
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78
https://elifesciences.org/articles/56223
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79
https://www.theatlantic.com/science/archive/2019/12/men-lose-y-chromosomes-cells-they-age/603013/
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80
https://www.karger.com/Article/Fulltext/330627
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https://www.researchgate.net/figure/Schematic-overview-of-elimination-of-extra-chromosome-21-chr-21-using-genome-editing_fig1_338730725
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82
https://www.synthego.com/blog/gene-drive-crispr
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83
https://www.smithsonianmag.com/science-nature/y-chromosome-may-be-doomed-180967887/
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https://learn.genetics.utah.edu/content/disorders/whatispgt
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https://www.medicalnewstoday.com/articles/what-chromosomes-are-affected-by-edwards-syndrome
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https://royalsociety.org/topics-policy/projects/genetic-technologies/what-are-genetic-technologies/
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https://www.ohio.edu/plantbio/staff/showalte/BIOL%20101%20Summer/Wiley%20Powerpoints/pruitt_ppt_ch05.ppt
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https://www.hopkinsmedicine.org/Press_releases/2006/07_06_06.html
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https://inside.upmc.com/cells-become-zombies-when-the-ends-of-their-chromosomes-are-damaged-a-tactic-both-helpful-and-harmful-for-health/
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90
https://news.berkeley.edu/2014/01/09/study-dispels-theories-of-y-chromosomes-demise/
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https://emedicine.medscape.com/article/273415-overview
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93
https://www.economist.com/science-and-technology/2014/03/27/diy-chromosomes
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https://www.nbcnews.com/healthmain/could-it-be-cure-breakthrough-prompts-down-syndrome-soul-searching-6c10879213
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https://www.spectrumnews.org/news/crispr-tweak-fixes-genetic-flaw-fragile-x-syndrome/
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https://vcahospitals.com/know-your-pet/genetics-basics-modes-of-inheritance
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https://www.khanacademy.org/science/biology/dna-as-the-genetic-material/dna-replication/a/dna-proofreading-and-repair
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