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Google Keyword Rankings for : dna repair telomerase
1
DNA Repair at Telomeres: Keeping the Ends Intact - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660827/
Each of these mechanisms maintains chromosome ends by repairing the damage owing to incomplete replication. Thus, a study of telomere maintenance is really a ...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660827/
Each of these mechanisms maintains chromosome ends by repairing the damage owing to incomplete replication. Thus, a study of telomere maintenance is really a ...
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2
Telomeres are favoured targets of a persistent DNA damage ...
https://www.nature.com/articles/ncomms1708
Telomere shortening has been shown to contribute to a persistent DNA damage response (DDR) during replicative senescence, the irreversible ...
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https://www.nature.com/articles/ncomms1708
Telomere shortening has been shown to contribute to a persistent DNA damage response (DDR) during replicative senescence, the irreversible ...
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3
The telomerase reverse transcriptase regulates ... - PNAS
https://www.pnas.org/doi/10.1073/pnas.0503095102
The observations presented herein implicate hTERT as a regulator of the DNA damage response pathway through its actions on chromatin structure. Surprisingly, ...
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https://www.pnas.org/doi/10.1073/pnas.0503095102
The observations presented herein implicate hTERT as a regulator of the DNA damage response pathway through its actions on chromatin structure. Surprisingly, ...
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4
DNA Repair and Telomeres — An Intriguing Relationship
https://www.intechopen.com/chapters/44309
Telomeres, the end of linear chromosomes, function to preserve chromosome integrity during each round of DNA replication, thus preventing chromosomal ends from ...
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https://www.intechopen.com/chapters/44309
Telomeres, the end of linear chromosomes, function to preserve chromosome integrity during each round of DNA replication, thus preventing chromosomal ends from ...
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5
Alternative lengthening of telomeres - Cell & Bioscience
https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-020-00391-6
Telomerase is a large ribonucleoprotein complex responsible for progressive synthesis of telomeric DNA repeats (TTAGGG) at the 3′ ends of linear ...
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https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-020-00391-6
Telomerase is a large ribonucleoprotein complex responsible for progressive synthesis of telomeric DNA repeats (TTAGGG) at the 3′ ends of linear ...
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6
Telomere maintenance in interplay with DNA repair in ...
https://academic.oup.com/mutage/article/35/3/261/5743334
After the replication of chromosomes, DNA end resection is required at newly synthesised telomeres to ensure that both sister chromatids acquire ...
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https://academic.oup.com/mutage/article/35/3/261/5743334
After the replication of chromosomes, DNA end resection is required at newly synthesised telomeres to ensure that both sister chromatids acquire ...
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7
The role of DNA damage and repair at telomeres - Yie Liu
https://grantome.com/grant/NIH/ZIA-AG000744-06
We have investigated whether telomeres are prone to oxidative DNA damage. In comparison to non-telomeric DNA, telomeric DNA harbors more oxidative base ...
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https://grantome.com/grant/NIH/ZIA-AG000744-06
We have investigated whether telomeres are prone to oxidative DNA damage. In comparison to non-telomeric DNA, telomeric DNA harbors more oxidative base ...
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8
The regulation of the DNA damage response at telomeres
https://portlandpress.com/biochemsoctrans/article/49/2/933/228161/The-regulation-of-the-DNA-damage-response-at
Telomeres identify chromosome termini and distinguish them from the ends of accidental double-strand breaks (DSBs) [1,2]. DSBs elicit a prompt ...
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https://portlandpress.com/biochemsoctrans/article/49/2/933/228161/The-regulation-of-the-DNA-damage-response-at
Telomeres identify chromosome termini and distinguish them from the ends of accidental double-strand breaks (DSBs) [1,2]. DSBs elicit a prompt ...
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9
Telomere-Preserving RNA Guided by DNA Repair Enzyme
https://www.genengnews.com/news/telomere-preserving-rna-guided-by-dna-repair-enzyme/
TERRA accumulates at chromosome ends, signaling that telomeres should be elongated or repaired. “Telomeric-repeat-containing RNA (TERRA) is a ...
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https://www.genengnews.com/news/telomere-preserving-rna-guided-by-dna-repair-enzyme/
TERRA accumulates at chromosome ends, signaling that telomeres should be elongated or repaired. “Telomeric-repeat-containing RNA (TERRA) is a ...
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10
Disruption of Telomere Integrity and DNA Repair Machineries ...
https://www.frontiersin.org/articles/10.3389/fimmu.2019.01152/full
Since telomeres are nucleoprotein complexes with a primary function of capping the chromosome ends to prevent unwanted DNA damage, we ...
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https://www.frontiersin.org/articles/10.3389/fimmu.2019.01152/full
Since telomeres are nucleoprotein complexes with a primary function of capping the chromosome ends to prevent unwanted DNA damage, we ...
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11
DNA repair factors and telomere-chromosome integrity in ...
https://www.karger.com/Article/Fulltext/77475
Telomere function may have contrasting roles: inducing replicative senescence and promoting tumourigenesis and these roles may vary between cell types depending ...
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https://www.karger.com/Article/Fulltext/77475
Telomere function may have contrasting roles: inducing replicative senescence and promoting tumourigenesis and these roles may vary between cell types depending ...
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12
Telomeres: Moonlighting by DNA repair proteins
https://www.cell.com/current-biology/pdf/S0960-9822(98)70315-X.pdf
Telomeres: Moonlighting by DNA repair proteins. David T. Weaver. Chromosome ends, or telomeres, are dynamic DNA structures maintained by a multisubunit ...
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https://www.cell.com/current-biology/pdf/S0960-9822(98)70315-X.pdf
Telomeres: Moonlighting by DNA repair proteins. David T. Weaver. Chromosome ends, or telomeres, are dynamic DNA structures maintained by a multisubunit ...
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13
DNA damage response at telomeres boosts the transcription ...
https://www.embopress.org/doi/10.15252/embr.202153658
During aging, telomere dysfunction accumulates and activates a DNA damage response, leading to increase of ACE2, the human SARS-CoV-2 ...
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https://www.embopress.org/doi/10.15252/embr.202153658
During aging, telomere dysfunction accumulates and activates a DNA damage response, leading to increase of ACE2, the human SARS-CoV-2 ...
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14
Telomeres and DNA damage checkpoints - ScienceDirect.com
https://www.sciencedirect.com/science/article/pii/S0300908404002287
In all eukaryotic organisms, interruptions in duplex DNA molecules elicit a DNA damage response, which includes activation of DNA repair machineries and ...
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https://www.sciencedirect.com/science/article/pii/S0300908404002287
In all eukaryotic organisms, interruptions in duplex DNA molecules elicit a DNA damage response, which includes activation of DNA repair machineries and ...
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15
The Response to DNA Damage at Telomeric Repeats and Its ...
https://www.mdpi.com/2073-4425/10/4/318/htm
Telomeric repeats, coated by the shelterin complex, prevent inappropriate activation of the DNA damage response at the ends of linear chromosomes.
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https://www.mdpi.com/2073-4425/10/4/318/htm
Telomeric repeats, coated by the shelterin complex, prevent inappropriate activation of the DNA damage response at the ends of linear chromosomes.
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16
Oxidative Stress Induces Persistent Telomeric DNA Damage ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110963
Among them is telomerase, which is a ribonucleoprotein complex that regulates telomere-length maintenance by adding telomeric repeats to the ...
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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110963
Among them is telomerase, which is a ribonucleoprotein complex that regulates telomere-length maintenance by adding telomeric repeats to the ...
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17
Early Loss of Telomerase Action in Yeast Creates a ...
https://journals.asm.org/doi/10.1128/MCB.00943-15
Telomeres cap the ends of chromosomes, protecting them from degradation and inappropriate DNA repair processes that can lead to genomic ...
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https://journals.asm.org/doi/10.1128/MCB.00943-15
Telomeres cap the ends of chromosomes, protecting them from degradation and inappropriate DNA repair processes that can lead to genomic ...
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18
Are Telomeres the Key to Aging and Cancer
https://learn.genetics.utah.edu/content/basics/telomeres/
Like the rest of a chromosome, including its genes, telomeres are sequences of DNA — chains of chemical code. Like all DNA, they are made of four nucleic acid ...
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https://learn.genetics.utah.edu/content/basics/telomeres/
Like the rest of a chromosome, including its genes, telomeres are sequences of DNA — chains of chemical code. Like all DNA, they are made of four nucleic acid ...
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19
Abstract PO-020: Telomerase reverse transcriptase inhibitor ...
https://aacrjournals.org/clincancerres/article/27/8_Supplement/PO-020/672006/Abstract-PO-020-Telomerase-reverse-transcriptase
In examining mechanisms of action, our RNA-seq analysis found that NU-1 affects not only telomere maintenance but also DNA damage response (DDR) ...
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https://aacrjournals.org/clincancerres/article/27/8_Supplement/PO-020/672006/Abstract-PO-020-Telomerase-reverse-transcriptase
In examining mechanisms of action, our RNA-seq analysis found that NU-1 affects not only telomere maintenance but also DNA damage response (DDR) ...
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20
Quantification of Double Stranded DNA Breaks and Telomere ...
https://tvst.arvojournals.org/article.aspx?articleid=2740078
Therefore, telomeres are indicative of the number of divisions the cell lineage has undergone and are a measure of replicative stress. Repair systems exist ( ...
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https://tvst.arvojournals.org/article.aspx?articleid=2740078
Therefore, telomeres are indicative of the number of divisions the cell lineage has undergone and are a measure of replicative stress. Repair systems exist ( ...
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21
Telomerase promotes formation of a telomere protective ...
https://www.science.org/doi/10.1126/sciadv.aav4409
The spontaneous telomeric DNA damage signals present in telomerase-positive cells are suppressed by overexpression of TRF2 (Fig. 5A), so it is likely that some ...
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https://www.science.org/doi/10.1126/sciadv.aav4409
The spontaneous telomeric DNA damage signals present in telomerase-positive cells are suppressed by overexpression of TRF2 (Fig. 5A), so it is likely that some ...
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22
First Glimpse of End-of Chromosome Repair in Real Time
https://www.pennmedicine.org/news/news-releases/2016/october/first-glimpse-of-endof-chromos
Telomeres stay intact in most cancer cell types by means of a specialized enzyme called telomerase that adds the repetitive telomere DNA ...
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https://www.pennmedicine.org/news/news-releases/2016/october/first-glimpse-of-endof-chromos
Telomeres stay intact in most cancer cell types by means of a specialized enzyme called telomerase that adds the repetitive telomere DNA ...
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23
Telomere-dependent and telomere-independent origins of ...
https://www.aging-us.com/article/100019/text
Human tumors and cultured cells contain elevated levels of endogenous DNA damage resulting from telomere dysfunction, replication and transcription errors, ...
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https://www.aging-us.com/article/100019/text
Human tumors and cultured cells contain elevated levels of endogenous DNA damage resulting from telomere dysfunction, replication and transcription errors, ...
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24
Characterizing the Role of DNA Repair Proteins in Telomere ...
https://trace.tennessee.edu/cgi/viewcontent.cgi?article=1828&context=utk_graddiss
We demonstrated that deletion of Fancc did not affect telomerase activity, telomere length or telomeric end- capping in mice with long telomeres. We also showed ...
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https://trace.tennessee.edu/cgi/viewcontent.cgi?article=1828&context=utk_graddiss
We demonstrated that deletion of Fancc did not affect telomerase activity, telomere length or telomeric end- capping in mice with long telomeres. We also showed ...
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25
The telomerase reverse transcriptase ... - Possemato lab
http://www.possematolab.med.nyu.edu/sites/default/files/pdfs/Masutomi-PNAS-2005.pdf
diminished capacity for DNA repair, and fragmented chromo- ... telomerase expression, DNA damage responses, and senescence,.
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http://www.possematolab.med.nyu.edu/sites/default/files/pdfs/Masutomi-PNAS-2005.pdf
diminished capacity for DNA repair, and fragmented chromo- ... telomerase expression, DNA damage responses, and senescence,.
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26
Pathways for maintenance of telomeres and common fragile ...
https://royalsocietypublishing.org/doi/10.1098/rsob.180018
Telomeres are the specialized nucleoprotein structures that protect the natural ends of linear eukaryotic chromosomes from being recognized as ...
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https://royalsocietypublishing.org/doi/10.1098/rsob.180018
Telomeres are the specialized nucleoprotein structures that protect the natural ends of linear eukaryotic chromosomes from being recognized as ...
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27
Telomeres and telomerase (article) | Khan Academy
https://www.khanacademy.org/science/biology/dna-as-the-genetic-material/dna-replication/a/telomeres-telomerase
Telomerase is an RNA-dependent DNA polymerase, meaning an enzyme that can make DNA using RNA as a template. How does telomerase work? The enzyme binds to a ...
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https://www.khanacademy.org/science/biology/dna-as-the-genetic-material/dna-replication/a/telomeres-telomerase
Telomerase is an RNA-dependent DNA polymerase, meaning an enzyme that can make DNA using RNA as a template. How does telomerase work? The enzyme binds to a ...
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28
A Novel Small Molecule That Alters Shelterin Integrity and ...
https://pubs.acs.org/doi/10.1021/ja805615w
Dysfunctional telomeres that are no longer protected by shelterin have been shown to activate the DNA-damage response machinery, which can ...
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https://pubs.acs.org/doi/10.1021/ja805615w
Dysfunctional telomeres that are no longer protected by shelterin have been shown to activate the DNA-damage response machinery, which can ...
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29
DNA damage - Inhibition of telomerase activity and cellular ...
https://commerce.bio-rad.com/en-cn/prime-pcr-assays/pathway/dna-damage-inhibition-telomerase-activity-cellular-senescence
During the proliferation of mammalian cells, the telomere shortens after every round of DNA replication. Critical telomere shortening or uncapping of telomere ...
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https://commerce.bio-rad.com/en-cn/prime-pcr-assays/pathway/dna-damage-inhibition-telomerase-activity-cellular-senescence
During the proliferation of mammalian cells, the telomere shortens after every round of DNA replication. Critical telomere shortening or uncapping of telomere ...
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30
Telomeres and Cancer: Resolving the Paradox
https://www.annualreviews.org/doi/pdf/10.1146/annurev-cancerbio-050420-023410
function of telomeres relies on their ability to initiate DNA damage ... DNA repair activities, leading to chromosome fusions and widespread cell death.
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https://www.annualreviews.org/doi/pdf/10.1146/annurev-cancerbio-050420-023410
function of telomeres relies on their ability to initiate DNA damage ... DNA repair activities, leading to chromosome fusions and widespread cell death.
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31
The rise of Apollo, protector of telomeres - ASH Publications
https://ashpublications.org/blood/article/139/16/2415/484906/The-rise-of-Apollo-protector-of-telomeres
Using a series of biochemical and genetic experiments, they showed that mutations affect both the DNA repair and telomere biology function of ...
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https://ashpublications.org/blood/article/139/16/2415/484906/The-rise-of-Apollo-protector-of-telomeres
Using a series of biochemical and genetic experiments, they showed that mutations affect both the DNA repair and telomere biology function of ...
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32
Challenging endings: How telomeres prevent fragility - Glousker
https://onlinelibrary.wiley.com/doi/full/10.1002/bies.202100157
Incomplete DNA synthesis at repair sites or partial chromatin condensation may become apparent as telomere fragility. Fragility and DNA repair ...
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https://onlinelibrary.wiley.com/doi/full/10.1002/bies.202100157
Incomplete DNA synthesis at repair sites or partial chromatin condensation may become apparent as telomere fragility. Fragility and DNA repair ...
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33
DNA Damage and Repair in Telomeres: Relation to Aging - jstor
https://www.jstor.org/stable/2366539
measured telomeric length, telomeric DNA damage, and its repair in relation to the progression of aging. Telomeres are shorter in fibroblasts from an old ...
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https://www.jstor.org/stable/2366539
measured telomeric length, telomeric DNA damage, and its repair in relation to the progression of aging. Telomeres are shorter in fibroblasts from an old ...
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34
Telomere shortening and DNA damage in culprit cells of ...
https://openres.ersjournals.com/content/7/2/00691-2020
Telomeres are DNA–protein complexes at the end of chromosomes which act as a buffer in cell cycle-dependent DNA shortening, thereby protecting the genetic ...
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https://openres.ersjournals.com/content/7/2/00691-2020
Telomeres are DNA–protein complexes at the end of chromosomes which act as a buffer in cell cycle-dependent DNA shortening, thereby protecting the genetic ...
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35
DNA replication and repair - Knowledge @ AMBOSS
https://www.amboss.com/us/knowledge/DNA_replication_and_repair/
Remove supercoils that develop during DNA elongation as parent DNA is separated by helicase. ; Remove supercoils that develop during DNA ...
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https://www.amboss.com/us/knowledge/DNA_replication_and_repair/
Remove supercoils that develop during DNA elongation as parent DNA is separated by helicase. ; Remove supercoils that develop during DNA ...
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36
Laboratory of Genomic Instability and Cancer Therapeutics
https://www.bumc.bu.edu/busm-pm/training-program/laboratories/laboratory-of-genome-instability-and-cancer-therapeutics/
These eroded telomeres are then recognized as substrates for DNA damage repair, stimulating the genomic instability that drives cancer progression.
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https://www.bumc.bu.edu/busm-pm/training-program/laboratories/laboratory-of-genome-instability-and-cancer-therapeutics/
These eroded telomeres are then recognized as substrates for DNA damage repair, stimulating the genomic instability that drives cancer progression.
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37
Telomere Dysfunction and DNA Damage Checkpoints in ...
https://www.gastrojournal.org/article/S0016-5085(09)01197-4/fulltext
Initiated tumors require telomerase activation in order to prevent high levels of chromosomal instability that induce genetic chaos and tumor ...
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https://www.gastrojournal.org/article/S0016-5085(09)01197-4/fulltext
Initiated tumors require telomerase activation in order to prevent high levels of chromosomal instability that induce genetic chaos and tumor ...
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38
Aging-US: DNA- and telomere-damage does not l - EurekAlert!
https://www.eurekalert.org/pub_releases/2021-03/ijl-ada030221.php
Aging-US: DNA- and telomere-damage does not limit lifespan: evidence from rapamycin ... Dr. Mikhail V. Blagosklonny said, "As a provocative title ...
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https://www.eurekalert.org/pub_releases/2021-03/ijl-ada030221.php
Aging-US: DNA- and telomere-damage does not limit lifespan: evidence from rapamycin ... Dr. Mikhail V. Blagosklonny said, "As a provocative title ...
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39
The Role of RAD4 in DNA Repair and Its Interplay with ...
https://bearworks.missouristate.edu/cgi/viewcontent.cgi?article=4315&context=theses
KEYWORDS: DNA repair, telomeres, RAD4, XPC, NER, Tetrahymena thermophila, ... stranded end of the telomere invades the upstream DNA duplex, base-pairing ...
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https://bearworks.missouristate.edu/cgi/viewcontent.cgi?article=4315&context=theses
KEYWORDS: DNA repair, telomeres, RAD4, XPC, NER, Tetrahymena thermophila, ... stranded end of the telomere invades the upstream DNA duplex, base-pairing ...
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40
Telomeres, Genomic Instability, DNA Repair and Breast Cancer
http://www.eurekaselect.com/article/35464
This review describes our current understanding of telomere length polymorphism and organization in breast cancer cells. The key roles of the telomeric DNA ...
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http://www.eurekaselect.com/article/35464
This review describes our current understanding of telomere length polymorphism and organization in breast cancer cells. The key roles of the telomeric DNA ...
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41
Telomere - Wikipedia
https://en.wikipedia.org/wiki/Telomere
A telomere is a region of repetitive nucleotide sequences associated with specialized proteins at the ends of linear chromosomes.
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https://en.wikipedia.org/wiki/Telomere
A telomere is a region of repetitive nucleotide sequences associated with specialized proteins at the ends of linear chromosomes.
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42
Determination of DNA damage and telomerase activity in ...
https://www.spandidos-publications.com/10.3892/etm.2016.3974
After 28 days, the animals were sacrificed, and DNA damage evaluation (comet assay) and telomerase activity assays were then performed using ...
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https://www.spandidos-publications.com/10.3892/etm.2016.3974
After 28 days, the animals were sacrificed, and DNA damage evaluation (comet assay) and telomerase activity assays were then performed using ...
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43
Dyskerin, telomerase and the DNA damage response
https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?referer=&httpsredir=1&article=4018&context=open_access_pubs
Here we discuss these results in terms of the role of dyskerin in telomere maintenance and the possible role that the DNA damage response plays ...
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https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?referer=&httpsredir=1&article=4018&context=open_access_pubs
Here we discuss these results in terms of the role of dyskerin in telomere maintenance and the possible role that the DNA damage response plays ...
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44
Regulation of Telomere Length by Checkpoint Genes ...
https://www.molbiolcell.org/doi/10.1091/mbc.9.3.611
We have studied telomere length in Schizosaccharomyces pombe strains carrying mutations affecting cell cycle checkpoints, DNA repair, ...
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https://www.molbiolcell.org/doi/10.1091/mbc.9.3.611
We have studied telomere length in Schizosaccharomyces pombe strains carrying mutations affecting cell cycle checkpoints, DNA repair, ...
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45
Investigating the links between telomerase and the DNA ...
https://www.findaphd.com/phds/project/investigating-the-links-between-telomerase-and-the-dna-damage-response-in-cancer-cells/?p146848
The ribonucleoprotein enzyme telomerase counteracts telomere shortening in a majority of cancers, allowing for unlimited cell division. Most normal cells do not ...
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https://www.findaphd.com/phds/project/investigating-the-links-between-telomerase-and-the-dna-damage-response-in-cancer-cells/?p146848
The ribonucleoprotein enzyme telomerase counteracts telomere shortening in a majority of cancers, allowing for unlimited cell division. Most normal cells do not ...
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46
The End Game: Targeting Telomere Processing in Cancer
https://www.aacr.org/blog/2022/09/16/the-end-game-targeting-telomere-processing-in-cancer/
Our DNA is also at risk of damage at its ends, but fortunately, DNA segments called telomeres, from the Greek root “telo” for end, ...
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https://www.aacr.org/blog/2022/09/16/the-end-game-targeting-telomere-processing-in-cancer/
Our DNA is also at risk of damage at its ends, but fortunately, DNA segments called telomeres, from the Greek root “telo” for end, ...
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47
Titia de Lange, Ph.D. - The Rockefeller University
https://www.rockefeller.edu/our-scientists/heads-of-laboratories/871-titia-de-lange/
In addition to protecting telomeres, shelterin plays a major role in the maintenance of telomeric DNA. Shelterin recruits telomerase, regulates telomere ...
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https://www.rockefeller.edu/our-scientists/heads-of-laboratories/871-titia-de-lange/
In addition to protecting telomeres, shelterin plays a major role in the maintenance of telomeric DNA. Shelterin recruits telomerase, regulates telomere ...
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48
Heart-Breaking Telomeres | Circulation Research
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.312202
In fact, telomere shortening can occur as a consequence of oxidative stress and inflammation that cause DNA damage and breaks with potential ...
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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.312202
In fact, telomere shortening can occur as a consequence of oxidative stress and inflammation that cause DNA damage and breaks with potential ...
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49
telomere maintenance Gene Ontology Term (GO:0000723)
http://www.informatics.jax.org/vocab/gene_ontology/GO:0000723
telomere maintenance · regulation of telomere length · Any process that contributes to the maintenance of proper telomeric length and structure by affecting and ...
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http://www.informatics.jax.org/vocab/gene_ontology/GO:0000723
telomere maintenance · regulation of telomere length · Any process that contributes to the maintenance of proper telomeric length and structure by affecting and ...
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50
Telomeres: The Role of Shortening in Cancer and Aging, How ...
https://www.healthline.com/health/telomeres
When you're stressed, your body releases hormones that can cause oxidative stress. This could result in more DNA damage and telomere shortening. Based on this ...
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https://www.healthline.com/health/telomeres
When you're stressed, your body releases hormones that can cause oxidative stress. This could result in more DNA damage and telomere shortening. Based on this ...
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51
Telomere extension turns back aging clock in cultured human ...
https://med.stanford.edu/news/all-news/2015/01/telomere-extension-turns-back-aging-clock-in-cultured-cells.html
Telomeres are the protective caps on the ends of the strands of DNA called chromosomes, which house our genomes. In young humans, telomeres ...
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https://med.stanford.edu/news/all-news/2015/01/telomere-extension-turns-back-aging-clock-in-cultured-cells.html
Telomeres are the protective caps on the ends of the strands of DNA called chromosomes, which house our genomes. In young humans, telomeres ...
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52
Telomerase - DNA Damage/DNA Repair - Signaling Pathways
https://www.apexbt.com/signaling-pathways/dna-damage-dna-repair/telomerase.html
Telomerase is a ribonucleoprotein polymerase that adds telomere repeat TTAGGG to maintain telomere ends. It plays roles in senescence, oncogenesis, ...
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https://www.apexbt.com/signaling-pathways/dna-damage-dna-repair/telomerase.html
Telomerase is a ribonucleoprotein polymerase that adds telomere repeat TTAGGG to maintain telomere ends. It plays roles in senescence, oncogenesis, ...
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53
DNA damage—how and why we age? - eLife
https://elifesciences.org/articles/62852
Many cells undergo senescence independently of telomere shorting due to replicative, mitochondrial, oxidative, metabolic, or genotoxic stress ( ...
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https://elifesciences.org/articles/62852
Many cells undergo senescence independently of telomere shorting due to replicative, mitochondrial, oxidative, metabolic, or genotoxic stress ( ...
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54
14.3D: Telomere Replication - Biology LibreTexts
https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Book%3A_General_Biology_(Boundless)/14%3A_DNA_Structure_and_Function/14.03%3A_DNA_Replication/14.3D%3A_Telomere_Replication
DNA polymerase cannot replicate and repair DNA molecules at the ends of linear chromosomes. · The ends of linear chromosomes, called telomeres, ...
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https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Book%3A_General_Biology_(Boundless)/14%3A_DNA_Structure_and_Function/14.03%3A_DNA_Replication/14.3D%3A_Telomere_Replication
DNA polymerase cannot replicate and repair DNA molecules at the ends of linear chromosomes. · The ends of linear chromosomes, called telomeres, ...
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55
Potential Leads from Ayurvedic Rasayana (Anti-Ageing) Drugs
https://repositorio-aberto.up.pt/bitstream/10216/135650/2/488420.pdf
in human cells, and thus, low telomerase activity, leads to the imminent appearance of short telomeres and to a low rate of DNA repair, ...
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https://repositorio-aberto.up.pt/bitstream/10216/135650/2/488420.pdf
in human cells, and thus, low telomerase activity, leads to the imminent appearance of short telomeres and to a low rate of DNA repair, ...
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56
Best DNA Repair Cream with Telomerase & Crushed Pearl
https://jenniferbradley.com/products/best-dna-repair-cream-w-telomerase-crushed-pearl
"Telomeres are the caps at the ends of chromosomes that protect DNA from damage. As we age, they get shorter. ... It's important to maintain our telomeres, so ...
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https://jenniferbradley.com/products/best-dna-repair-cream-w-telomerase-crushed-pearl
"Telomeres are the caps at the ends of chromosomes that protect DNA from damage. As we age, they get shorter. ... It's important to maintain our telomeres, so ...
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57
Investigating the links between telomerase and the DNA ...
https://www.sydney.edu.au/research/opportunities/111.html
The ribonucleoprotein enzyme telomerase counteracts telomere shortening in a majority of cancers, allowing for unlimited cell division.
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https://www.sydney.edu.au/research/opportunities/111.html
The ribonucleoprotein enzyme telomerase counteracts telomere shortening in a majority of cancers, allowing for unlimited cell division.
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58
CoV-2 receptor ACE2 during aging - bioRxiv
https://www.biorxiv.org/content/10.1101/2021.06.09.447484v1.full.pdf
DNA damage response at telomeres boosts the transcription of SARS- ... Aging is associated with telomere shortening and damage in several ...
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https://www.biorxiv.org/content/10.1101/2021.06.09.447484v1.full.pdf
DNA damage response at telomeres boosts the transcription of SARS- ... Aging is associated with telomere shortening and damage in several ...
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59
Shorter Telomeres on Chromosomes, DNA Damage May ...
https://sclerodermanews.com/news/shorter-telomeres-dna-damage-contribute-ssc/
The results together suggest that telomere shortening and DNA damage may be involved in SSc-related fibrosis, and targeting these processes ...
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https://sclerodermanews.com/news/shorter-telomeres-dna-damage-contribute-ssc/
The results together suggest that telomere shortening and DNA damage may be involved in SSc-related fibrosis, and targeting these processes ...
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60
[PDF] The DNA damage response at dysfunctional telomeres ...
https://www.semanticscholar.org/paper/The-DNA-damage-response-at-dysfunctional-telomeres%2C-Muraki-Murnane/d940c064d7703732d61185a482519e9988ce430d
When DNA double-strand breaks occur near telomeres in normal cells, the cells stop proliferating, while in cancer cells, subtelomeric DSBs induce ...
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https://www.semanticscholar.org/paper/The-DNA-damage-response-at-dysfunctional-telomeres%2C-Muraki-Murnane/d940c064d7703732d61185a482519e9988ce430d
When DNA double-strand breaks occur near telomeres in normal cells, the cells stop proliferating, while in cancer cells, subtelomeric DSBs induce ...
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61
DNA Repair and Telomeres — An Intriguing Relationship - OpenAIRE
https://www.openaire.eu/search/publication?articleId=intech______::99e2cbfc357aa6098b65b4814217a26d
Recent advances in DNA repair and telomere biology further establish an intimate interrela‐ tionship between these cellular attributes, in the maintenance ...
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https://www.openaire.eu/search/publication?articleId=intech______::99e2cbfc357aa6098b65b4814217a26d
Recent advances in DNA repair and telomere biology further establish an intimate interrela‐ tionship between these cellular attributes, in the maintenance ...
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62
Telomere maintenance and disease - The Lancet
https://www.thelancet.com/pb-assets/Lancet/extras/02art7027web.pdf
Telomere biology. Telomeres are found at the ends of linear chromosomes. In most eukaryotes, functional telomeres are constituted by short, tandem DNA ...
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https://www.thelancet.com/pb-assets/Lancet/extras/02art7027web.pdf
Telomere biology. Telomeres are found at the ends of linear chromosomes. In most eukaryotes, functional telomeres are constituted by short, tandem DNA ...
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63
Study finds telomeres can set damage thresholds for cancer ...
https://www.news-medical.net/news/20220921/Study-finds-telomeres-can-set-damage-thresholds-for-cancer-cells-above-which-they-cannot-continue-to-divide.aspx
Telomers represent the region that constitutes the end of chromosomes and is protected by telomere-binding proteins.
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https://www.news-medical.net/news/20220921/Study-finds-telomeres-can-set-damage-thresholds-for-cancer-cells-above-which-they-cannot-continue-to-divide.aspx
Telomers represent the region that constitutes the end of chromosomes and is protected by telomere-binding proteins.
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64
Telomere Maintenance - Chromatin Networks
https://malone.bioquant.uni-heidelberg.de/research/TelomereMaintenance/index.html
Therefore, maintaining telomere length is a crucial feature of cancers. To elongate their telomeres, most cancer cells reactivate telomerase, an enzyme which is ...
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https://malone.bioquant.uni-heidelberg.de/research/TelomereMaintenance/index.html
Therefore, maintaining telomere length is a crucial feature of cancers. To elongate their telomeres, most cancer cells reactivate telomerase, an enzyme which is ...
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65
Video: How telomere shortening affects aging - RepeatDx
https://repeatdx.com/video-telomere-shortening-aging/
Telomeres are unique structures of proteins and DNA, found on the ends of our chromosomes. Each time cells replicate, the number of DNA repeats ...
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https://repeatdx.com/video-telomere-shortening-aging/
Telomeres are unique structures of proteins and DNA, found on the ends of our chromosomes. Each time cells replicate, the number of DNA repeats ...
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66
Telomere shortening is associated with poor prognosis and ...
https://www.lungcancerjournal.info/article/S0169-5002(07)00664-2/fulltext
Telomere function and DNA damage response pathways are frequently inactivated in cancer. Moreover, some telomere-binding proteins have been ...
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https://www.lungcancerjournal.info/article/S0169-5002(07)00664-2/fulltext
Telomere function and DNA damage response pathways are frequently inactivated in cancer. Moreover, some telomere-binding proteins have been ...
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67
Telomere DNA Repair Cream - Cosmetic Solutions
https://naturalskincare.com/product/telomere-dna-repair-cream/
Telomere DNA Repair Cream ... This powerful corrective cream targets multiple signs of aging to renew and rejuvenate the skin while you sleep. It acts on specific ...
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https://naturalskincare.com/product/telomere-dna-repair-cream/
Telomere DNA Repair Cream ... This powerful corrective cream targets multiple signs of aging to renew and rejuvenate the skin while you sleep. It acts on specific ...
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68
Embryonic stem cells have their own strategy for protecting ...
https://ccr.cancer.gov/news/article/embryonic-stem-cells-have-their-own-strategy-for-protecting-chromosome-ends
D., an NIH Stadtman investigator in CCR's Laboratory of Genomic Integrity, has found that rather than treating exposed telomeres as damaged DNA ...
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https://ccr.cancer.gov/news/article/embryonic-stem-cells-have-their-own-strategy-for-protecting-chromosome-ends
D., an NIH Stadtman investigator in CCR's Laboratory of Genomic Integrity, has found that rather than treating exposed telomeres as damaged DNA ...
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69
Investigation of DNA damage response at interstitial telomeric ...
https://bura.brunel.ac.uk/handle/2438/22985
Two telomere maintenance mechanisms are known to exist. Telomerase, an enzyme that synthesises new tandem repeats onto the end of linear chromosome and ALT ( ...
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https://bura.brunel.ac.uk/handle/2438/22985
Two telomere maintenance mechanisms are known to exist. Telomerase, an enzyme that synthesises new tandem repeats onto the end of linear chromosome and ALT ( ...
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70
Telomere dysfunction threatens the integrity of the genome
https://www.mskcc.org/research/ski/labs/john-maciejowski/telomere-dysfunction-threatens-integrity-genome
Nuclear envelope rupturing promotes DNA damage and genome instability, potentially acting as a potent mutagen during cancer cell metastasis.
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https://www.mskcc.org/research/ski/labs/john-maciejowski/telomere-dysfunction-threatens-integrity-genome
Nuclear envelope rupturing promotes DNA damage and genome instability, potentially acting as a potent mutagen during cancer cell metastasis.
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71
The DNA damage response at dysfunctional telomeres, and at ...
https://www.jstage.jst.go.jp/article/ggs/92/3/92_17-00014/_html/-char/en
These pathways are tightly regulated to maintain chromosome integrity. The ends of chromosomes, called telomeres, contain telomeric DNA that forms a cap ...
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https://www.jstage.jst.go.jp/article/ggs/92/3/92_17-00014/_html/-char/en
These pathways are tightly regulated to maintain chromosome integrity. The ends of chromosomes, called telomeres, contain telomeric DNA that forms a cap ...
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72
What are telomeres? - MBInfo
https://www.mechanobio.info/genome-regulation/what-are-telomeres/
Telomeres are short nucleotide sequences found at the end of linear chromosomes which protect the genetic information. · During DNA replication, the double ...
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https://www.mechanobio.info/genome-regulation/what-are-telomeres/
Telomeres are short nucleotide sequences found at the end of linear chromosomes which protect the genetic information. · During DNA replication, the double ...
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73
Hidden secret of immortality enzyme telomerase - ScienceDaily
https://www.sciencedaily.com/releases/2018/02/180227142114.htm
Telomerase lengthens telomeres by repeatedly synthesizing very short DNA repeats of six nucleotides -- the building blocks of DNA -- with the ...
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https://www.sciencedaily.com/releases/2018/02/180227142114.htm
Telomerase lengthens telomeres by repeatedly synthesizing very short DNA repeats of six nucleotides -- the building blocks of DNA -- with the ...
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74
Regrowing Their Tails Prevents DNA Repair And Can Shorten ...
https://www.iflscience.com/regrowing-their-tails-prevents-dna-repair-and-shortens-lizards-lives-53056
The ends of chromosomes are capped by telomeres, which provide protection against various sorts of damage. With rare exceptions, most of our ...
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https://www.iflscience.com/regrowing-their-tails-prevents-dna-repair-and-shortens-lizards-lives-53056
The ends of chromosomes are capped by telomeres, which provide protection against various sorts of damage. With rare exceptions, most of our ...
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75
Telomere - National Human Genome Research Institute
https://www.genome.gov/genetics-glossary/Telomere
A telomere is a region of repetitive DNA sequences at the end of a chromosome. Telomeres protect the ends of chromosomes from becoming ...
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https://www.genome.gov/genetics-glossary/Telomere
A telomere is a region of repetitive DNA sequences at the end of a chromosome. Telomeres protect the ends of chromosomes from becoming ...
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76
Telomeres and Telomerase - iBiology
https://www.ibiology.org/genetics-and-gene-regulation/telomerase/
Telomerase adds DNA to telomeres at the end of chromosomes. Dr. Blackburn explains that without telomerase, telomeres shorten with each cell division ...
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https://www.ibiology.org/genetics-and-gene-regulation/telomerase/
Telomerase adds DNA to telomeres at the end of chromosomes. Dr. Blackburn explains that without telomerase, telomeres shorten with each cell division ...
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77
Telomeres and Lobsters: A Story About Aging
https://geneticdirection.com/2018/09/26/telomeres-and-lobsters-a-story-about-aging/
That's upwards of a billion chances for something to go wrong, but because the mechanisms involved in DNA repair and cell division are so ...
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https://geneticdirection.com/2018/09/26/telomeres-and-lobsters-a-story-about-aging/
That's upwards of a billion chances for something to go wrong, but because the mechanisms involved in DNA repair and cell division are so ...
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78
Why We Age: Telomere Attrition - Lifespan.io
https://www.lifespan.io/topic/telomere-attrition/
All the cell needs to do in this instance is to have the repair enzyme look to see if the damage is near the end of the chromosome; if a damaged ...
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https://www.lifespan.io/topic/telomere-attrition/
All the cell needs to do in this instance is to have the repair enzyme look to see if the damage is near the end of the chromosome; if a damaged ...
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79
Why telomeres shorten and restoration strategies in aging
https://www.youtube.com/watch?v=EZ4haz4LR-M
The Sheekey Science Show
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https://www.youtube.com/watch?v=EZ4haz4LR-M
The Sheekey Science Show
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80
End of ageing and cancer? Scientists unveil structure of the ...
https://theconversation.com/end-of-ageing-and-cancer-scientists-unveil-structure-of-the-immortality-enzyme-telomerase-95591
Enter telomerase, a specialised telomere repair enzyme in two parts – able to add DNA to the chromosome tips. The first part is a protein ...
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https://theconversation.com/end-of-ageing-and-cancer-scientists-unveil-structure-of-the-immortality-enzyme-telomerase-95591
Enter telomerase, a specialised telomere repair enzyme in two parts – able to add DNA to the chromosome tips. The first part is a protein ...
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81
Targeting telomeres, the timekeepers of cells, could improve ...
https://www.salk.edu/news-release/targeting-telomeres-the-timekeepers-of-cells-could-improve-chemotherapy/
Typically, telomeres have a protein protecting them from being identified as damaged DNA by the cell and thus prevented them from proceeding ...
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https://www.salk.edu/news-release/targeting-telomeres-the-timekeepers-of-cells-could-improve-chemotherapy/
Typically, telomeres have a protein protecting them from being identified as damaged DNA by the cell and thus prevented them from proceeding ...
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82
Benefits of Telomeres in Reversing Age & Gene Therapy
https://stemcellthailand.org/telomere-function-replication/
Telomeres are essentially the “butts” of single cell chromosomes. They are the tail end of a repetitive DNA structure that is highly related ...
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https://stemcellthailand.org/telomere-function-replication/
Telomeres are essentially the “butts” of single cell chromosomes. They are the tail end of a repetitive DNA structure that is highly related ...
→ Check Latest Keyword Rankings ←
83
The telomere problem.. how the cells fix this.. - incrediblebiology
https://sites.google.com/site/incrediblebiology/lab-videos/thetelomereproblemhowthecellsfixthis
Like aglets on shoelaces, telomeres protect the tips of the chromosome from 'fraying.' Without them, DNA repair enzymes might recognize the tips ...
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https://sites.google.com/site/incrediblebiology/lab-videos/thetelomereproblemhowthecellsfixthis
Like aglets on shoelaces, telomeres protect the tips of the chromosome from 'fraying.' Without them, DNA repair enzymes might recognize the tips ...
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84
Anti-aging science: In search of eternal youth
https://english.elpais.com/science-tech/2022-11-17/anti-aging-science-in-search-of-eternal-youth.html
To counteract telomere shortening, Blasco advocates the use of telomerase activators. Telomerase is an enzyme that enables telomere DNA to ...
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https://english.elpais.com/science-tech/2022-11-17/anti-aging-science-in-search-of-eternal-youth.html
To counteract telomere shortening, Blasco advocates the use of telomerase activators. Telomerase is an enzyme that enables telomere DNA to ...
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85
Exam 4- Everything cell division Flashcards | Quizlet
https://quizlet.com/748371043/exam-4-everything-cell-division-flash-cards/
A) Telomerase. B) Single Stranded Binding Proteins. C) DNA Helicase. D) Topoisomerase. D. What can occur when DNA damage happens: A) Deamination.
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https://quizlet.com/748371043/exam-4-everything-cell-division-flash-cards/
A) Telomerase. B) Single Stranded Binding Proteins. C) DNA Helicase. D) Topoisomerase. D. What can occur when DNA damage happens: A) Deamination.
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86
New Research Directions in DNA Repair
https://books.google.com/books?id=CXafDwAAQBAJ&pg=PA357&lpg=PA357&dq=dna+repair+telomerase&source=bl&ots=bPEr4Zq9F7&sig=ACfU3U1nCj-JkLj7OZUegvsLUgBpoE1cMw&hl=en&sa=X&ved=2ahUKEwifo8DngdD7AhWslGoFHUYvB5UQ6AF6BQjdAhAD
In this model telomeres from adjacent chromosomes could serve as templates [147,155], resulting in a net increase in telomeric DNA.
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https://books.google.com/books?id=CXafDwAAQBAJ&pg=PA357&lpg=PA357&dq=dna+repair+telomerase&source=bl&ots=bPEr4Zq9F7&sig=ACfU3U1nCj-JkLj7OZUegvsLUgBpoE1cMw&hl=en&sa=X&ved=2ahUKEwifo8DngdD7AhWslGoFHUYvB5UQ6AF6BQjdAhAD
In this model telomeres from adjacent chromosomes could serve as templates [147,155], resulting in a net increase in telomeric DNA.
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87
Overview of senescence and cellular aging (2022) - Rainis
https://rainis.pics/article/overview-of-senescence-and-cellular-aging
Telomere sequences cannot be completely replicated by DNA polymerase, leading to their progressive shortening in most somatic cells. Transformed ...
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https://rainis.pics/article/overview-of-senescence-and-cellular-aging
Telomere sequences cannot be completely replicated by DNA polymerase, leading to their progressive shortening in most somatic cells. Transformed ...
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88
Dr. Rhonda Patrick On Longevity, Epigenetics & The Microbiome
https://www.richroll.com/podcast/rhonda-patrick/
DNA damage and telomerase; the importance of Vitamin D; Rhonda's recommended supplements; gene polymorphisms; nutrition/lifestyle & athletic ...
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https://www.richroll.com/podcast/rhonda-patrick/
DNA damage and telomerase; the importance of Vitamin D; Rhonda's recommended supplements; gene polymorphisms; nutrition/lifestyle & athletic ...
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89
Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response
https://books.google.com/books?id=qUdLDwAAQBAJ&pg=PA8&lpg=PA8&dq=dna+repair+telomerase&source=bl&ots=Jdymo6QJNh&sig=ACfU3U1C7DPFbdGrACOm4s-mhRiVd05ZAQ&hl=en&sa=X&ved=2ahUKEwifo8DngdD7AhWslGoFHUYvB5UQ6AF6BQjfAhAD
Keywords: ubiquitin, SUMO, telomere maintenance, telomere dysfunction, DNA damage, DNA repair, shelterin, telomerase INTRODUCTION Genome stability is ...
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https://books.google.com/books?id=qUdLDwAAQBAJ&pg=PA8&lpg=PA8&dq=dna+repair+telomerase&source=bl&ots=Jdymo6QJNh&sig=ACfU3U1C7DPFbdGrACOm4s-mhRiVd05ZAQ&hl=en&sa=X&ved=2ahUKEwifo8DngdD7AhWslGoFHUYvB5UQ6AF6BQjfAhAD
Keywords: ubiquitin, SUMO, telomere maintenance, telomere dysfunction, DNA damage, DNA repair, shelterin, telomerase INTRODUCTION Genome stability is ...
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90
Advances in Hematopoietic Stem Cell Research
https://books.google.com/books?id=9JefDwAAQBAJ&pg=PA23&lpg=PA23&dq=dna+repair+telomerase&source=bl&ots=U6uuIWo6Kf&sig=ACfU3U2g3SnzllJToFoym7hrJrnRcxz8TQ&hl=en&sa=X&ved=2ahUKEwifo8DngdD7AhWslGoFHUYvB5UQ6AF6BQjhAhAD
This idea has given rise to the notion that many aspects of normal aging could primarily reflect limitations in DNA repair and telomere-maintenance pathways ...
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https://books.google.com/books?id=9JefDwAAQBAJ&pg=PA23&lpg=PA23&dq=dna+repair+telomerase&source=bl&ots=U6uuIWo6Kf&sig=ACfU3U2g3SnzllJToFoym7hrJrnRcxz8TQ&hl=en&sa=X&ved=2ahUKEwifo8DngdD7AhWslGoFHUYvB5UQ6AF6BQjhAhAD
This idea has given rise to the notion that many aspects of normal aging could primarily reflect limitations in DNA repair and telomere-maintenance pathways ...
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91
Lobsters don't die from old age — they die from exhaustion
https://bigthink.com/thinking/lobsters-jellyfish-foolish-quest-immortality/
We need our cells to divide so that we can grow and repair. ... and so a bit less effective after each subsequent cell division at protecting our DNA.
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https://bigthink.com/thinking/lobsters-jellyfish-foolish-quest-immortality/
We need our cells to divide so that we can grow and repair. ... and so a bit less effective after each subsequent cell division at protecting our DNA.
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92
All Nobel Prizes
https://www.nobelprize.org/prizes/lists/all-nobel-prizes/
“for mechanistic studies of DNA repair” ... “for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase” ...
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https://www.nobelprize.org/prizes/lists/all-nobel-prizes/
“for mechanistic studies of DNA repair” ... “for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase” ...
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93
Targeted Cancer Therapy Recent Developments in Targeted ...
https://askaila.online/60216-targeted-cancer-therapy-recent-developments-in-targeted-cancer-treatment-cancer-genetic-and-epigenetic-changes-ten-hallmarks-of-cancer/
The first antitelomerase is an oligonucleotide-based molecule GRN163L ... (CHKs) mitotic kinases, and abnormal DNA damage repair responses.
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https://askaila.online/60216-targeted-cancer-therapy-recent-developments-in-targeted-cancer-treatment-cancer-genetic-and-epigenetic-changes-ten-hallmarks-of-cancer/
The first antitelomerase is an oligonucleotide-based molecule GRN163L ... (CHKs) mitotic kinases, and abnormal DNA damage repair responses.
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94
Plant Genome Diversity Volume 1: Plant Genomes, their ...
https://books.google.com/books?id=L9qZ4Y2ZSzQC&pg=PA77&lpg=PA77&dq=dna+repair+telomerase&source=bl&ots=xM2pDLACW7&sig=ACfU3U0Pm-KFMZd3uhAHKv6zhhtqGR_zPQ&hl=en&sa=X&ved=2ahUKEwifo8DngdD7AhWslGoFHUYvB5UQ6AF6BQjeAhAD
DNA repair proteins may be present at telomeres as it is thought that chromosome ... This may be important both for telomere extension by telomerase and the ...
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https://books.google.com/books?id=L9qZ4Y2ZSzQC&pg=PA77&lpg=PA77&dq=dna+repair+telomerase&source=bl&ots=xM2pDLACW7&sig=ACfU3U0Pm-KFMZd3uhAHKv6zhhtqGR_zPQ&hl=en&sa=X&ved=2ahUKEwifo8DngdD7AhWslGoFHUYvB5UQ6AF6BQjeAhAD
DNA repair proteins may be present at telomeres as it is thought that chromosome ... This may be important both for telomere extension by telomerase and the ...
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exercise | Lab Land
https://www.emoryhealthsciblog.com/tag/exercise/
 Specifically, the durable DNA modification known as methylation is involved, ... including preventing damage to the heart after a heart attack.
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https://www.emoryhealthsciblog.com/tag/exercise/
 Specifically, the durable DNA modification known as methylation is involved, ... including preventing damage to the heart after a heart attack.
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