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Google Keyword Rankings for : multiplicity issues in clinical trials
1
committee for proprietary medicinal products (cpmp) points to ...
https://www.ema.europa.eu/en/documents/scientific-guideline/points-consider-multiplicity-issues-clinical-trials_en.pdf
The usual concern with multiplicity is that, if it is not properly handled, unsubstantiated claims for the effectiveness of a drug may be made as a consequence ...
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https://www.ema.europa.eu/en/documents/scientific-guideline/points-consider-multiplicity-issues-clinical-trials_en.pdf
The usual concern with multiplicity is that, if it is not properly handled, unsubstantiated claims for the effectiveness of a drug may be made as a consequence ...
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2
An introduction to multiplicity issues in clinical trials: the what ...
https://pubmed.ncbi.nlm.nih.gov/28025257/
In clinical trials it is not uncommon to face a multiple testing problem which can have an impact on both type I and type II error rates, ...
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https://pubmed.ncbi.nlm.nih.gov/28025257/
In clinical trials it is not uncommon to face a multiple testing problem which can have an impact on both type I and type II error rates, ...
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3
Multiplicity Considerations in Clinical Trials
https://www.nejm.org/doi/pdf/10.1056/NEJMra1709701
Multiplicity, or the use of many comparisons in a clinical trial, increases the likelihood that a chance association could be deemed causal.
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https://www.nejm.org/doi/pdf/10.1056/NEJMra1709701
Multiplicity, or the use of many comparisons in a clinical trial, increases the likelihood that a chance association could be deemed causal.
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4
Multiplicity – What is it, and why is it important?
https://www.quantics.co.uk/blog/multiplicity-what-is-it-and-why-is-it-important/
Multiplicity is an issue that should be controlled for in clinical studies which: Assess the primary endpoint in more than one way.
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https://www.quantics.co.uk/blog/multiplicity-what-is-it-and-why-is-it-important/
Multiplicity is an issue that should be controlled for in clinical studies which: Assess the primary endpoint in more than one way.
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5
Prevalence of Multiplicity and Appropriate Adjustments Among ...
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2764653
Multiplicity refers to the “potential inflation of type I error rate as a result of multiple testing, for example because of multiple subgroup ...
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https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2764653
Multiplicity refers to the “potential inflation of type I error rate as a result of multiple testing, for example because of multiple subgroup ...
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6
Editorial: Multiplicity issues in clinical trials - Wiley Online Library
https://onlinelibrary.wiley.com/doi/full/10.1002/sim.7506
Examples of trials with a single multiplicity component include trials with one primary end point evaluated in two or more patient populations, ...
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https://onlinelibrary.wiley.com/doi/full/10.1002/sim.7506
Examples of trials with a single multiplicity component include trials with one primary end point evaluated in two or more patient populations, ...
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7
Problems of multiplicity in clinical trials - ScienceDirect
https://www.sciencedirect.com/science/article/pii/037837589490197X
Most of the uncertainties in the conclusions of randomized clinical trials results either from inadequate sample size or from problems of multiplicity.
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https://www.sciencedirect.com/science/article/pii/037837589490197X
Most of the uncertainties in the conclusions of randomized clinical trials results either from inadequate sample size or from problems of multiplicity.
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8
Quick Guide to Biostatistics in Clinical Research: Multiplicity
https://www.enago.com/academy/quick-guide-to-biostatistics-in-clinical-research-multiplicity/
Clinical trials very often involve performing multiple comparisons on the clinical data. This leads to multiplicity problem.
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https://www.enago.com/academy/quick-guide-to-biostatistics-in-clinical-research-multiplicity/
Clinical trials very often involve performing multiple comparisons on the clinical data. This leads to multiplicity problem.
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9
a survey of clinical trials units and a rapid review of published ...
https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-022-01525-9
An open-ended question “What do you think are the common problem areas for multiplicity? Where is research needed?” gave responses summarised in ...
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https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-022-01525-9
An open-ended question “What do you think are the common problem areas for multiplicity? Where is research needed?” gave responses summarised in ...
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10
Key Multiplicity Issues in Clinical Trials I (Module A) - YouTube
https://www.youtube.com/watch?v=eWQJ3gYb_sY
ASA Biopharmaceutical Section
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https://www.youtube.com/watch?v=eWQJ3gYb_sY
ASA Biopharmaceutical Section
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11
Multiplicity Problem in Clinical Trials and Some ... - YouTube
https://www.youtube.com/watch?v=n-cx_rFT64M
Nov 20, 2019
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https://www.youtube.com/watch?v=n-cx_rFT64M
Nov 20, 2019
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12
Multiplicity in clinical trial: An ignored concept
https://ijdvl.com/multiplicity-in-clinical-trial-an-ignored-concept/
Multiplicity is an inevitable issue in the interpretation of clinical trial data. It is defined as the potential inflation of type-I error ...
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https://ijdvl.com/multiplicity-in-clinical-trial-an-ignored-concept/
Multiplicity is an inevitable issue in the interpretation of clinical trial data. It is defined as the potential inflation of type-I error ...
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13
An introduction to multiplicity issues in clinical trials
https://www.researchgate.net/publication/311947626_An_introduction_to_multiplicity_issues_in_clinical_trials_the_what_why_when_and_how
In clinical trials it is not uncommon to face a multiple testing problem which can have an impact on both type I and type II error rates, leading to ...
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https://www.researchgate.net/publication/311947626_An_introduction_to_multiplicity_issues_in_clinical_trials_the_what_why_when_and_how
In clinical trials it is not uncommon to face a multiple testing problem which can have an impact on both type I and type II error rates, leading to ...
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14
Multiplicity Issues in Clinical Trials With Multiple Objectives
https://www.tandfonline.com/doi/full/10.1080/19466315.2013.807749
Multiplicity refers to situations in a trial in which multiple statistical comparisons or analyses on endpoints create multiple ways to “win” for treatment ...
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https://www.tandfonline.com/doi/full/10.1080/19466315.2013.807749
Multiplicity refers to situations in a trial in which multiple statistical comparisons or analyses on endpoints create multiple ways to “win” for treatment ...
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15
Adjustment for multiplicity - On Biostatistics and Clinical Trials
http://onbiostatistics.blogspot.com/2009/05/adjustment-for-multiplicity.html
› 2009/05 › adjustm...
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http://onbiostatistics.blogspot.com/2009/05/adjustment-for-multiplicity.html
› 2009/05 › adjustm...
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16
Multiple testing: when should we adjust for multiplicity?
https://www.statsimprove.com/en/multiple-testing-when-should-we-adjust-for-multiplicity/
The problem of multiplicity is a problem that concerns almost all scientific ... study designs of a clinical trial are potentially infinite.
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https://www.statsimprove.com/en/multiple-testing-when-should-we-adjust-for-multiplicity/
The problem of multiplicity is a problem that concerns almost all scientific ... study designs of a clinical trial are potentially infinite.
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17
Introduction to Multiplicity in Clinical Trials
https://www2.cscc.unc.edu/impact7/system/files/Bretz_Slides.pdf
Multiple test problems in clinical trials are very diverse and many different methods are available. Sources of Multiplicity. Overview.
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https://www2.cscc.unc.edu/impact7/system/files/Bretz_Slides.pdf
Multiple test problems in clinical trials are very diverse and many different methods are available. Sources of Multiplicity. Overview.
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18
Multiple Endpoints in Clinical Trials Guidance for Industry - FDA
https://www.fda.gov/regulatory-information/search-fda-guidance-documents/multiple-endpoints-clinical-trials-guidance-industry
As the number of endpoints analyzed in a single trial increases, the likelihood of making false conclusions about a drug's effects with respect ...
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https://www.fda.gov/regulatory-information/search-fda-guidance-documents/multiple-endpoints-clinical-trials-guidance-industry
As the number of endpoints analyzed in a single trial increases, the likelihood of making false conclusions about a drug's effects with respect ...
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19
Key Multiplicity Issues in Clinical Trials - online donation form
https://higherlogicdownload.s3.amazonaws.com/AMSTAT/fa4dd52c-8429-41d0-abdf-0011047bfa19/UploadedImages/Webinars/2017/2017-06_Dmitrienko.pdf
Multiplicity issues in clinical trials. Biopharmaceutical Section's webinar series. Alex Dmitrienko (Mediana Inc). Slide 6. FDA guidance.
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https://higherlogicdownload.s3.amazonaws.com/AMSTAT/fa4dd52c-8429-41d0-abdf-0011047bfa19/UploadedImages/Webinars/2017/2017-06_Dmitrienko.pdf
Multiplicity issues in clinical trials. Biopharmaceutical Section's webinar series. Alex Dmitrienko (Mediana Inc). Slide 6. FDA guidance.
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20
Multiplicity Problem in Clinical Trials and Some ... - Statswork
https://statswork.medium.com/multiplicity-problem-in-clinical-trials-and-some-statistical-approaches-b9a7fcc4245f?source=post_internal_links---------4----------------------------
In conclusion, multiplicity problem is not uncommon in the clinical trials if we have one or more treatment in the study. Thus, more appropriate statistical ...
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https://statswork.medium.com/multiplicity-problem-in-clinical-trials-and-some-statistical-approaches-b9a7fcc4245f?source=post_internal_links---------4----------------------------
In conclusion, multiplicity problem is not uncommon in the clinical trials if we have one or more treatment in the study. Thus, more appropriate statistical ...
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21
Multiplicity Considerations in the Design and Analysis of ... - jstor
https://www.jstor.org/stable/2983471
surrounding multiplicity in clinical trials. It is most common to address multiplicity concerns by attempting to formulate statistical tests of significance ...
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https://www.jstor.org/stable/2983471
surrounding multiplicity in clinical trials. It is most common to address multiplicity concerns by attempting to formulate statistical tests of significance ...
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22
Multiplicity issues in clinical trials for multiple groups
https://stats.stackexchange.com/questions/584257/multiplicity-issues-in-clinical-trials-for-multiple-groups
Given the conversation in the comments, I gather this is a study to examine if a new procedure will reduce bleeding following hip replacement ...
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https://stats.stackexchange.com/questions/584257/multiplicity-issues-in-clinical-trials-for-multiple-groups
Given the conversation in the comments, I gather this is a study to examine if a new procedure will reduce bleeding following hip replacement ...
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23
Multiplicity Problems in Clinical Trials: A Regulatory Perspective
https://www.taylorfrancis.com/chapters/edit/10.1201/9781584889854-6/multiplicity-problems-clinical-trials-regulatory-perspective-mohammad-huque-joachim-ro%C2%A8hmel
Confirmatory controlled clinical trials, also known as Phase III clinical trials, when successful, are significant achievements in medical research as they.
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https://www.taylorfrancis.com/chapters/edit/10.1201/9781584889854-6/multiplicity-problems-clinical-trials-regulatory-perspective-mohammad-huque-joachim-ro%C2%A8hmel
Confirmatory controlled clinical trials, also known as Phase III clinical trials, when successful, are significant achievements in medical research as they.
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24
On the need to adjust for multiplicity in ... - Annals of Oncology
https://www.annalsofoncology.org/article/S0923-7534(19)31123-8/fulltext
] use this term for a trial in which patients with a common mutation are recruited from populations with different tumor types. The effect of the experimental ...
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https://www.annalsofoncology.org/article/S0923-7534(19)31123-8/fulltext
] use this term for a trial in which patients with a common mutation are recruited from populations with different tumor types. The effect of the experimental ...
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25
ASA Biopharmaceutical Section Statistics Workshop
https://ww2.amstat.org/meetings/fdaworkshop/index.cfm?fuseaction=AbstractDetails&AbstractID=301581
The last decade has witnessed a surge of research in the development of principles and methods for addressing multiplicity issues of clinical trials for ...
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https://ww2.amstat.org/meetings/fdaworkshop/index.cfm?fuseaction=AbstractDetails&AbstractID=301581
The last decade has witnessed a surge of research in the development of principles and methods for addressing multiplicity issues of clinical trials for ...
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26
Chapter 1 - Multiplicity Problems in Clinical Trials - NJIT
https://web.njit.edu/~wguo/Math654_2012/DTB_Chapter1.pdf
A trial can also fail because of poor planning or disregarding multiplicity issues with respect to multiple endpoints and multiple comparisons. Clinical trials ...
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https://web.njit.edu/~wguo/Math654_2012/DTB_Chapter1.pdf
A trial can also fail because of poor planning or disregarding multiplicity issues with respect to multiple endpoints and multiple comparisons. Clinical trials ...
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27
Multiplicity Problems in the Clinical Trial and Some Statistical ...
https://link.springer.com/chapter/10.1007/978-4-431-68544-9_1
In a clinical trial there arise a variety of multiplicity problems which might cause the bias and need to be considered carefully in analyzing and ...
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https://link.springer.com/chapter/10.1007/978-4-431-68544-9_1
In a clinical trial there arise a variety of multiplicity problems which might cause the bias and need to be considered carefully in analyzing and ...
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28
Some Thoughts on Clinical Trials, Especially Problems of ...
https://www.science.org/doi/10.1126/science.333584
by JW Tukey · 1977 · Cited by 551 —
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https://www.science.org/doi/10.1126/science.333584
by JW Tukey · 1977 · Cited by 551 —
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29
Multiplicity Issues in Clinical Trials-Look at it with a magnifying ...
https://www.lexjansen.com/phuse/2016/sp/SP04.pdf
Multiplicity arises when a trial departs from simple design to complex design because of multiple tests, when one considers a set of statistical inferences.
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https://www.lexjansen.com/phuse/2016/sp/SP04.pdf
Multiplicity arises when a trial departs from simple design to complex design because of multiple tests, when one considers a set of statistical inferences.
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30
Points to consider on multiplicity issues in clinical trials
https://www.tga.gov.au/resources/resource/international-scientific-guidelines/international-scientific-guideline-points-consider-multiplicity-issues-clinical-trials
International scientific guideline: Points to consider on multiplicity issues in clinical trials · Print · Share ...
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https://www.tga.gov.au/resources/resource/international-scientific-guidelines/international-scientific-guideline-points-consider-multiplicity-issues-clinical-trials
International scientific guideline: Points to consider on multiplicity issues in clinical trials · Print · Share ...
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31
Multiplicity Guidelines
https://www.niss.org/sites/default/files/event_attachments/Alex%20Dmitrienko%27s%20slides.pdf
Multiplicity Guidelines. Slide 3. FDA guideline. Draft guidance on multiplicity issues in clinical trials (2017). EMA guideline.
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https://www.niss.org/sites/default/files/event_attachments/Alex%20Dmitrienko%27s%20slides.pdf
Multiplicity Guidelines. Slide 3. FDA guideline. Draft guidance on multiplicity issues in clinical trials (2017). EMA guideline.
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32
EU regulatory guidance on multiplicity issues and missing data
http://www.diaglobal.org/productfiles/14562/armin.koch.pdf
Two guidelines refer to the topics discussed in this meeting: Points to consider on multiplicity issues in clinical trials. (CPMP/EWP/908/99).
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http://www.diaglobal.org/productfiles/14562/armin.koch.pdf
Two guidelines refer to the topics discussed in this meeting: Points to consider on multiplicity issues in clinical trials. (CPMP/EWP/908/99).
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33
(Draft) Guideline on multiplicity issues in clinical trials
http://benjaminhofner.de/downloads/2017/talks/Hofner_2017_Multiplicity.pdf
(Draft) Guideline on multiplicity issues in clinical trials. Dr. Benjamin Hofner. Section Biostatistics. Forum Biomedizinische Arzneimittel.
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http://benjaminhofner.de/downloads/2017/talks/Hofner_2017_Multiplicity.pdf
(Draft) Guideline on multiplicity issues in clinical trials. Dr. Benjamin Hofner. Section Biostatistics. Forum Biomedizinische Arzneimittel.
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34
Submission of comments on ' Guideline on multiplicity issues ...
http://www.acrohealth.org/wp-content/uploads/2018/01/EMA-Draft-Guidline-on-Multiplicity.pdf
issues in clinical trials' (EMA/CHMP/44762/2017). Comments from: ... the guidance on multiplicity concerns, acknowledging this important issue in both the ...
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http://www.acrohealth.org/wp-content/uploads/2018/01/EMA-Draft-Guidline-on-Multiplicity.pdf
issues in clinical trials' (EMA/CHMP/44762/2017). Comments from: ... the guidance on multiplicity concerns, acknowledging this important issue in both the ...
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35
Multiplicity Problems in Clinical Trials – A Regulatory ...
https://www.bassconference.org/tutorials/BASS%202014%20Huque_Fritsch.pdf
addressing multiplicity issues in clinical trials. Statistics in. Medicine 2013. •. Dmitrienko A, D'Agostino RB, and Huque MF. Key.
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https://www.bassconference.org/tutorials/BASS%202014%20Huque_Fritsch.pdf
addressing multiplicity issues in clinical trials. Statistics in. Medicine 2013. •. Dmitrienko A, D'Agostino RB, and Huque MF. Key.
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36
FDA explains how to use secondary endpoints in clinical trials ...
https://www.engage.hoganlovells.com/knowledgeservices/news/fda-explains-how-to-use-secondary-endpoints-in-clinical-trials-to-show-efficacy
When a single statistical test is performed on the composite endpoint, there is no multiplicity problem. · For these endpoints, choice of (and ...
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https://www.engage.hoganlovells.com/knowledgeservices/news/fda-explains-how-to-use-secondary-endpoints-in-clinical-trials-to-show-efficacy
When a single statistical test is performed on the composite endpoint, there is no multiplicity problem. · For these endpoints, choice of (and ...
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37
CONTROLLING MULTIPLICITY IN CONFIRMATORY ... - CORE
https://core.ac.uk/download/pdf/210601413.pdf
complex multiplicity problem, we propose a strategy based on multi-way averages in Chapter 3. We apply this strategy to a cardiovascular clinical trial, ...
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https://core.ac.uk/download/pdf/210601413.pdf
complex multiplicity problem, we propose a strategy based on multi-way averages in Chapter 3. We apply this strategy to a cardiovascular clinical trial, ...
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38
Multiplicity Problem in Clinical Trials and Some ... - Issuu
https://issuu.com/statswork/docs/multiplicity_problem_in_clinical_trials_and_some_s
› statswork › docs › multiplicity_prob...
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https://issuu.com/statswork/docs/multiplicity_problem_in_clinical_trials_and_some_s
› statswork › docs › multiplicity_prob...
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39
Multiple Endpoints in Clinical Trials; Guidance for Industry
https://www.federalregister.gov/documents/2022/10/21/2022-22882/multiple-endpoints-in-clinical-trials-guidance-for-industry-availability
Failure to account for multiplicity when there are several clinical endpoints evaluated in a clinical trial can lead to false positive ...
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https://www.federalregister.gov/documents/2022/10/21/2022-22882/multiple-endpoints-in-clinical-trials-guidance-for-industry-availability
Failure to account for multiplicity when there are several clinical endpoints evaluated in a clinical trial can lead to false positive ...
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40
1 EMA Workshop on Multiplicity Issues in Clinical Trials - EFSPI
https://www.efspi.org/documents/activities/ema_workshop_on_multiplicity_issues_in_clinical_trials_nov_2012.pdf
standards and strategies to address multiplicity in clinical trials and to identify issues where guidance is missing so far.
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https://www.efspi.org/documents/activities/ema_workshop_on_multiplicity_issues_in_clinical_trials_nov_2012.pdf
standards and strategies to address multiplicity in clinical trials and to identify issues where guidance is missing so far.
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41
Multiplicity in clinical trial: An ignored concept
https://www.semanticscholar.org/paper/Multiplicity-in-clinical-trial%3A-An-ignored-concept-Thakur-Lahiry/1333693ab1a0942584947ee093b813fd4f9f4fb8
Frequentist evaluation of group sequential clinical trial designs. ... An introduction to multiplicity issues in clinical trials: the what, why, ...
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https://www.semanticscholar.org/paper/Multiplicity-in-clinical-trial%3A-An-ignored-concept-Thakur-Lahiry/1333693ab1a0942584947ee093b813fd4f9f4fb8
Frequentist evaluation of group sequential clinical trial designs. ... An introduction to multiplicity issues in clinical trials: the what, why, ...
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42
EMA Can Do More With Its Guidance On Multiplicity Issues In ...
https://pink.pharmaintelligence.informa.com/PS121138/EMA-Can-Do-More-With-Its-Guidance-On-Multiplicity-Issues-In-Clinical-Trials-Says-EFPIA
An addendum to the International Council for Harmonisation's guideline on statistical principles for clinical trials proposes a new framework on ...
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https://pink.pharmaintelligence.informa.com/PS121138/EMA-Can-Do-More-With-Its-Guidance-On-Multiplicity-Issues-In-Clinical-Trials-Says-EFPIA
An addendum to the International Council for Harmonisation's guideline on statistical principles for clinical trials proposes a new framework on ...
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43
Guideline on Multiplicity Issues in Clinical Trials - ISCTM
https://isctm.org/public_access/170629-SUBMITTED-ISCTM-Comments-EMA-Guideline-on-Multiplicity-Issues-in-Clinical-Trials.pdf
The International Society for CNS Clinical Trials and Methodology, ISCTM, ... proposal on managing multiplicity issues in clinical trials.
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https://isctm.org/public_access/170629-SUBMITTED-ISCTM-Comments-EMA-Guideline-on-Multiplicity-Issues-in-Clinical-Trials.pdf
The International Society for CNS Clinical Trials and Methodology, ISCTM, ... proposal on managing multiplicity issues in clinical trials.
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44
FDA Draft Guidance on Multiplicity | 2017 Duke Industry ...
https://sites.duke.edu/diss2017/program/fda-draft-guidance-on-multiplicity/
Despite recent advance in methods for handling multiple endpoints in clinical trials, some challenges remain. In this presentation I will discuss some of these ...
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https://sites.duke.edu/diss2017/program/fda-draft-guidance-on-multiplicity/
Despite recent advance in methods for handling multiple endpoints in clinical trials, some challenges remain. In this presentation I will discuss some of these ...
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45
Non-adjustment for multiple testing in multi-arm trials of ...
https://journals.sagepub.com/doi/10.1177/1740774520941419
8. Li, G, Taljaard, M, Van den Heuvel, ER, et al. An introduction to multiplicity issues in clinical trials: the what, why, when and how. Int J ...
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https://journals.sagepub.com/doi/10.1177/1740774520941419
8. Li, G, Taljaard, M, Van den Heuvel, ER, et al. An introduction to multiplicity issues in clinical trials: the what, why, when and how. Int J ...
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46
Multiple testing problems in classical clinical trial and adaptive ...
https://open.bu.edu/handle/2144/33080
Abstract. Multiplicity issues arise prevalently in a variety of situations in clinical trials and statistical methods for multiple testing have gradually gained ...
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https://open.bu.edu/handle/2144/33080
Abstract. Multiplicity issues arise prevalently in a variety of situations in clinical trials and statistical methods for multiple testing have gradually gained ...
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47
MULTIPLE COMPARISONS IN CLINICAL TRIALS
https://www.cdnetwork.org/wp-content/uploads/2018/05/The-Multiple-Comparisons-Problem-in-Clinical-Trials.pdf
THE PROBLEM OF MULTIPLICITY. • Multiplicity refers to the multiple judgments and inferences we make from data. – hypothesis tests.
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https://www.cdnetwork.org/wp-content/uploads/2018/05/The-Multiple-Comparisons-Problem-in-Clinical-Trials.pdf
THE PROBLEM OF MULTIPLICITY. • Multiplicity refers to the multiple judgments and inferences we make from data. – hypothesis tests.
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48
Multiple Endpoints in Clinical Trials: FDA Issues Draft Guidance
https://www.raps.org/regulatory-focus%E2%84%A2/news-articles/2017/1/multiple-endpoints-in-clinical-trials-fda-issues-draft-guidance
“As the number of endpoints analyzed in a single trial increases, the likelihood of making false conclusions about a drug's effects with respect ...
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https://www.raps.org/regulatory-focus%E2%84%A2/news-articles/2017/1/multiple-endpoints-in-clinical-trials-fda-issues-draft-guidance
“As the number of endpoints analyzed in a single trial increases, the likelihood of making false conclusions about a drug's effects with respect ...
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49
Multiplicity Issues in Adaptive Designs - Cytel
https://www.cytel.com/hubfs/0-library-0/pdfs/2013_Basel_Koenig_final.pdf
Multiplicity issues and type I error inflation. Adaptive graph-based multiple testing ... 1 address multiplicity in complex clinical trials ...
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https://www.cytel.com/hubfs/0-library-0/pdfs/2013_Basel_Koenig_final.pdf
Multiplicity issues and type I error inflation. Adaptive graph-based multiple testing ... 1 address multiplicity in complex clinical trials ...
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50
Multiplicity Expert for Clinical Trials - MultXpert
http://multxpert.com/wiki/MultXpert_package
Presentations on multiplicity issues and subgroup analysis in clinical trials were given at the Joint Statistical Meetings in Montreal, ...
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http://multxpert.com/wiki/MultXpert_package
Presentations on multiplicity issues and subgroup analysis in clinical trials were given at the Joint Statistical Meetings in Montreal, ...
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51
Understand and master multiplicity in practical situations
https://theeffectivestatistician.com/understand-and-master-multiplicity-in-practical-situations-interview-with-alex-dmitrienko/
378, 2115-2122. European Medicines Agency. Guideline on multiplicity issues in clinical trials. 2017. U.S. Food and Drug Administration. Multiple endpoints in ...
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https://theeffectivestatistician.com/understand-and-master-multiplicity-in-practical-situations-interview-with-alex-dmitrienko/
378, 2115-2122. European Medicines Agency. Guideline on multiplicity issues in clinical trials. 2017. U.S. Food and Drug Administration. Multiple endpoints in ...
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52
Staburo commented on EMA 'Guideline on multiplicity issues ...
https://staburo.com/staburo-commented-guideline-multiplicity-issues-clinical-trials/
Staburo submitted comments on EMA's draft guideline on multiplicity issues in clinical trials. Multiplicity issues arise in many areas of ...
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https://staburo.com/staburo-commented-guideline-multiplicity-issues-clinical-trials/
Staburo submitted comments on EMA's draft guideline on multiplicity issues in clinical trials. Multiplicity issues arise in many areas of ...
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53
Submission of comments form - EFPIA
https://www.efpia.eu/media/219866/efpia-comments_draft-guideline-on-multiplicity-issues-300617final-1.docx
... EMA Draft “Guideline on multiplicity issues in clinical trials” ... than one question in a single clinical trial, multiplicity issues ...
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https://www.efpia.eu/media/219866/efpia-comments_draft-guideline-on-multiplicity-issues-300617final-1.docx
... EMA Draft “Guideline on multiplicity issues in clinical trials” ... than one question in a single clinical trial, multiplicity issues ...
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54
Why, when and how to adjust for multiplicity in clinical trials
https://www.sismec.info/rivista/bmsce/category/24-bmsce-iv?download=157:why-when-and-how-to-adjust-for-multiplicity-in-clinical-trials-a-perspective-on-regulatory-activities
Over the past decade, the multiplicity issue has been of increasing concern in the clinical trials area both from a statistical and regulatory perspective.
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https://www.sismec.info/rivista/bmsce/category/24-bmsce-iv?download=157:why-when-and-how-to-adjust-for-multiplicity-in-clinical-trials-a-perspective-on-regulatory-activities
Over the past decade, the multiplicity issue has been of increasing concern in the clinical trials area both from a statistical and regulatory perspective.
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55
a survey of clinical trials units and a ra
https://research-information.bris.ac.uk/files/311326411/s12874_022_01525_9.pdf
multiplicity in publicly funded pragmatic randomised controlled trials: a ... Background: Opinions and practices vary around the issue of performing ...
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https://research-information.bris.ac.uk/files/311326411/s12874_022_01525_9.pdf
multiplicity in publicly funded pragmatic randomised controlled trials: a ... Background: Opinions and practices vary around the issue of performing ...
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56
Award DRF-2017-10-126 - NIHR Funding and Awards
https://fundingawards.nihr.ac.uk/award/DRF-2017-10-126
Although the issue of multiplicity is generally well-documented, ... In addition, a survey of UK registered clinical trials units (CTUs) will be undertaken ...
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https://fundingawards.nihr.ac.uk/award/DRF-2017-10-126
Although the issue of multiplicity is generally well-documented, ... In addition, a survey of UK registered clinical trials units (CTUs) will be undertaken ...
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57
On the need to adjust for multiplicity in confirmatory ... - CentAUR
http://centaur.reading.ac.uk/81732/8/mdz038.pdf
confirmatory clinical trials with master protocols. Annals of ... Multiplicity issues may arise when multiple hypothesis tests are.
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http://centaur.reading.ac.uk/81732/8/mdz038.pdf
confirmatory clinical trials with master protocols. Annals of ... Multiplicity issues may arise when multiple hypothesis tests are.
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58
Multiplicity Framework - EU-PEARL
https://eu-pearl.eu/wp-content/uploads/2020/12/EU-PEARL_SWS_Multiplicity.pdf
What are the main sources of multiplicity in complex trial designs? ... (2020b). Points to consider on multiplicity issues in clinical trials, EMA (2002) ...
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https://eu-pearl.eu/wp-content/uploads/2020/12/EU-PEARL_SWS_Multiplicity.pdf
What are the main sources of multiplicity in complex trial designs? ... (2020b). Points to consider on multiplicity issues in clinical trials, EMA (2002) ...
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59
Statistical Issues Multiplicity Missing data - ERIQA
http://www.eriqa-project.com/_upload/conferences_25.pdf
What is multiplicity? 1. Subgroups ... Subgroup analysis and other (mis)uses of baseline data in clinical trials ... multiplicity issues in clinical trials.
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http://www.eriqa-project.com/_upload/conferences_25.pdf
What is multiplicity? 1. Subgroups ... Subgroup analysis and other (mis)uses of baseline data in clinical trials ... multiplicity issues in clinical trials.
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60
Multiplicity adjustment in clinical trials with multiple correlated ...
https://content.iospress.com/articles/model-assisted-statistics-and-applications/mas375
Statistical analyses of commonly occurring clinical trials that have correlated primary endpoints are often complex because multiple ...
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https://content.iospress.com/articles/model-assisted-statistics-and-applications/mas375
Statistical analyses of commonly occurring clinical trials that have correlated primary endpoints are often complex because multiple ...
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61
Statistical Controversies in Reporting of Clinical Trials: Part 2 ...
https://www.jacc.org/doi/abs/10.1016/j.jacc.2015.10.023
This paper tackles several statistical controversies that are commonly faced when reporting a major clinical trial. Topics covered include: multiplicity of ...
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https://www.jacc.org/doi/abs/10.1016/j.jacc.2015.10.023
This paper tackles several statistical controversies that are commonly faced when reporting a major clinical trial. Topics covered include: multiplicity of ...
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62
On controversial statistical issues in clinical research | OAJCT
https://www.dovepress.com/on-controversial-statistical-issues-in-clinical-research-peer-reviewed-fulltext-article-OAJCT
Abstract: In clinical development of a test treatment under investigation, clinical trials are often conducted for evaluation of safety and ...
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https://www.dovepress.com/on-controversial-statistical-issues-in-clinical-research-peer-reviewed-fulltext-article-OAJCT
Abstract: In clinical development of a test treatment under investigation, clinical trials are often conducted for evaluation of safety and ...
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63
Contemporary Clinical Trials - UCL Discovery
https://discovery.ucl.ac.uk/id/eprint/10141136/1/Multiciplicity%20adjustment%20CCT%202021.pdf
Multiplicity adjustments in parallel-group multi-arm trials sharing a ... deline/draft-guideline-multiplicity-issues-clinical-trials_en.pdf, ...
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https://discovery.ucl.ac.uk/id/eprint/10141136/1/Multiciplicity%20adjustment%20CCT%202021.pdf
Multiplicity adjustments in parallel-group multi-arm trials sharing a ... deline/draft-guideline-multiplicity-issues-clinical-trials_en.pdf, ...
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64
Multiplicity and flexibility in clinical trials - MedUni Wien
http://www.meduniwien.ac.at/fwf_adaptive/papers/Brannath_2007_11.pdf
Multiplicity and flexibility issues are among the major topics in the current discussion on clinical trial designs for pharmaceutical ...
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http://www.meduniwien.ac.at/fwf_adaptive/papers/Brannath_2007_11.pdf
Multiplicity and flexibility issues are among the major topics in the current discussion on clinical trial designs for pharmaceutical ...
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65
Review Looks at Statistical Controversies in Clinical Trials
https://www.acc.org/latest-in-cardiology/articles/2015/12/07/15/42/review-looks-at-statistical-controversies-in-clinical-trials-multiplicity-of-data-and-more
Multiplicity of data, i.e., the large number of variables collected at baseline and during follow-up, presents a challenge to objectivity when ...
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https://www.acc.org/latest-in-cardiology/articles/2015/12/07/15/42/review-looks-at-statistical-controversies-in-clinical-trials-multiplicity-of-data-and-more
Multiplicity of data, i.e., the large number of variables collected at baseline and during follow-up, presents a challenge to objectivity when ...
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66
CLRES 2810 Statistical Methods and Issues in Clinical Trials
https://www.icre.pitt.edu/coursecatalog/syllabus/103.pdf
We will use manuscripts on clinical trials to facilitate learning of concepts discussed in class. ... Describe some solutions to multiplicity issues.
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https://www.icre.pitt.edu/coursecatalog/syllabus/103.pdf
We will use manuscripts on clinical trials to facilitate learning of concepts discussed in class. ... Describe some solutions to multiplicity issues.
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67
EMA issues draft guidance on multiplicity issues in clinical ...
https://uk.practicallaw.thomsonreuters.com/w-007-3942?transitionType=Default&contextData=(sc.Default)
The EMA is consulting on a draft guideline on multiplicity issues in clinical trials. ... To access this resource, sign up for a free trial of ...
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https://uk.practicallaw.thomsonreuters.com/w-007-3942?transitionType=Default&contextData=(sc.Default)
The EMA is consulting on a draft guideline on multiplicity issues in clinical trials. ... To access this resource, sign up for a free trial of ...
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68
How to Handle Multiplicity in Clinical Trial Data - Dummies.com
https://www.dummies.com/article/academics-the-arts/science/biology/how-to-handle-multiplicity-in-clinical-trial-data-150011/
Don't control for multiplicity and accept the likelihood that some of your "significant" findings will be falsely significant. This strategy is ...
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https://www.dummies.com/article/academics-the-arts/science/biology/how-to-handle-multiplicity-in-clinical-trial-data-150011/
Don't control for multiplicity and accept the likelihood that some of your "significant" findings will be falsely significant. This strategy is ...
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69
Multiple Testing Problems in Pharmaceutical Statistics
https://www.routledge.com/Multiple-Testing-Problems-in-Pharmaceutical-Statistics/Dmitrienko-Tamhane-Bretz/p/book/9781584889847
Multiplicity Problems in Clinical Trials: A Regulatory Perspective. Multiple Testing Methodology. Multiple Testing in Dose Response Problems. Analysis of ...
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https://www.routledge.com/Multiple-Testing-Problems-in-Pharmaceutical-Statistics/Dmitrienko-Tamhane-Bretz/p/book/9781584889847
Multiplicity Problems in Clinical Trials: A Regulatory Perspective. Multiple Testing Methodology. Multiple Testing in Dose Response Problems. Analysis of ...
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70
Multiplicity adjustments in parallel-group multi-arm trials ...
https://researchonline.lshtm.ac.uk/id/eprint/4666407/7/Molloy_etal_2021_Multiplicity-adjustments-in-parallel-group.pdf
Multi-arm, parallel-group clinical trials are an efficient way of ... The key issue in determining whether to control for multiplicity is.
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https://researchonline.lshtm.ac.uk/id/eprint/4666407/7/Molloy_etal_2021_Multiplicity-adjustments-in-parallel-group.pdf
Multi-arm, parallel-group clinical trials are an efficient way of ... The key issue in determining whether to control for multiplicity is.
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71
Multiple Endpoints in Confirmatory Clinical Trials
https://nursing.wayne.edu/ohr/2021-01-19-testing_specific_hypotheses_in_regression.pdf
Multiple Endpoints in. Confirmatory Clinical. Trials: Multiplicity. Issues. Thomas N Templin, Ph D. Office of Health Research.
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https://nursing.wayne.edu/ohr/2021-01-19-testing_specific_hypotheses_in_regression.pdf
Multiple Endpoints in. Confirmatory Clinical. Trials: Multiplicity. Issues. Thomas N Templin, Ph D. Office of Health Research.
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72
Subgroup analysis in clinical trials
https://www.mja.com.au/system/files/issues/180_06_150304/coo10086_fm.pdf
document Points to consider on multiplicity issues in clinical trials3) strongly encourage appropriate subgroup analyses.
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https://www.mja.com.au/system/files/issues/180_06_150304/coo10086_fm.pdf
document Points to consider on multiplicity issues in clinical trials3) strongly encourage appropriate subgroup analyses.
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73
Clinical Trial Optimization in drug development
https://gpaux.github.io/2021-04-17-book-release/
This book presents CSE-based clinical trial optimization approaches through a variety of common drug development challenges arising during the ...
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https://gpaux.github.io/2021-04-17-book-release/
This book presents CSE-based clinical trial optimization approaches through a variety of common drug development challenges arising during the ...
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74
Multiple Testing Problems in Pharmaceutical Statistics ...
https://www.amazon.com/Multiple-Problems-Pharmaceutical-Statistics-Biostatistics/dp/1584889845
In each chapter, the expert contributors describe important multiplicity problems encountered in pre-clinical and clinical trial settings.
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https://www.amazon.com/Multiple-Problems-Pharmaceutical-Statistics-Biostatistics/dp/1584889845
In each chapter, the expert contributors describe important multiplicity problems encountered in pre-clinical and clinical trial settings.
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75
Advanced multiplicity adjustment methods in clinical trials
https://www.deepdyve.com/lp/wiley/advanced-multiplicity-adjustment-methods-in-clinical-trials-AVTjEpbF1x
During the last decade, many novel approaches for addressing multiplicity problems arising in clinical trials have been introduced in the ...
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https://www.deepdyve.com/lp/wiley/advanced-multiplicity-adjustment-methods-in-clinical-trials-AVTjEpbF1x
During the last decade, many novel approaches for addressing multiplicity problems arising in clinical trials have been introduced in the ...
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76
Interventional Study Randomized controlled trial (RCT)
https://www.escardio.org/static_file/Escardio/Subspecialty/Working%20Groups/Cardiovascular%20Pharmacotherapy/education/resources%20&%20logo/01.Ceconi_Overview-of-clinical-trials.ppt
An overview of the different aspects of clinical trials. Claudio Ceconi ... Hunting expedition vs. fishing expedition; Multiplicity Issues.
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https://www.escardio.org/static_file/Escardio/Subspecialty/Working%20Groups/Cardiovascular%20Pharmacotherapy/education/resources%20&%20logo/01.Ceconi_Overview-of-clinical-trials.ppt
An overview of the different aspects of clinical trials. Claudio Ceconi ... Hunting expedition vs. fishing expedition; Multiplicity Issues.
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77
Composite Endpoints: Proceed with Caution
https://www.appliedclinicaltrialsonline.com/view/composite-endpoints-proceed-caution
The use of a composite endpoint in a clinical trial is usually justified ... "Points to Consider on Multiplicity Issues in Clinical Trials," ...
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https://www.appliedclinicaltrialsonline.com/view/composite-endpoints-proceed-caution
The use of a composite endpoint in a clinical trial is usually justified ... "Points to Consider on Multiplicity Issues in Clinical Trials," ...
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78
Analysis of Clinical Trials Using SAS: A Practical Guide, ...
https://books.google.com/books?id=nFsvDwAAQBAJ&pg=PA180&lpg=PA180&dq=multiplicity+issues+in+clinical+trials&source=bl&ots=pviimL0U65&sig=ACfU3U0lxVJUvrTDWp9iq_bdlwk1zPQKlA&hl=en&sa=X&ved=2ahUKEwjZuqel5NH7AhXGpVYBHQAWAJMQ6AF6BQi2AhAD
It is commonly accepted that multiplicity issues in the primary analysis must be addressed in all confirmatory clinical trials. In modern clinical trials, ...
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https://books.google.com/books?id=nFsvDwAAQBAJ&pg=PA180&lpg=PA180&dq=multiplicity+issues+in+clinical+trials&source=bl&ots=pviimL0U65&sig=ACfU3U0lxVJUvrTDWp9iq_bdlwk1zPQKlA&hl=en&sa=X&ved=2ahUKEwjZuqel5NH7AhXGpVYBHQAWAJMQ6AF6BQi2AhAD
It is commonly accepted that multiplicity issues in the primary analysis must be addressed in all confirmatory clinical trials. In modern clinical trials, ...
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79
Synthetic engineering and biological containment of ... - PNAS
https://www.pnas.org/doi/10.1073/pnas.2206739119
In recent years, with the global spread of drug-resistant bacterial infections, phage-based therapy (or “phage therapy”) has gained attention. Clinical trials ...
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https://www.pnas.org/doi/10.1073/pnas.2206739119
In recent years, with the global spread of drug-resistant bacterial infections, phage-based therapy (or “phage therapy”) has gained attention. Clinical trials ...
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80
Advances and Challenges in Adult ADHD - Psychiatric Times
https://www.psychiatrictimes.com/view/advances-and-challenges-in-adult-adhd
It's got a chronic and rather unremitting impact on functioning, and we need to approach it in a multiplicity of ways,'” Rostain said.
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https://www.psychiatrictimes.com/view/advances-and-challenges-in-adult-adhd
It's got a chronic and rather unremitting impact on functioning, and we need to approach it in a multiplicity of ways,'” Rostain said.
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81
Campbell And Farrell Biochemistry 7th Edition - Camusat
https://efms-myanmar.camusat.com/uploads/vampire?f=B8B8E3&FileName=Campbell_And_Farrell_Biochemistry_7th_Edition
These topics were first introduced in section I within a natural ... Biotechnology is a dynamic field with changes across R&D, clinical trials, ...
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https://efms-myanmar.camusat.com/uploads/vampire?f=B8B8E3&FileName=Campbell_And_Farrell_Biochemistry_7th_Edition
These topics were first introduced in section I within a natural ... Biotechnology is a dynamic field with changes across R&D, clinical trials, ...
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82
What works to promote research-policy engagement? in
https://bristoluniversitypressdigital.com/view/journals/evp/18/4/article-p691.xml
This multiplicity is for a number of reasons. ... in may be looking to understand a policy problem through reading across different narratives and framings.
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https://bristoluniversitypressdigital.com/view/journals/evp/18/4/article-p691.xml
This multiplicity is for a number of reasons. ... in may be looking to understand a policy problem through reading across different narratives and framings.
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83
Ayurveda - Wikipedia
https://en.wikipedia.org/wiki/Ayurveda
... well-designed clinical trials and systematic research reviews suggest that Ayurvedic approaches are effective". The NCCIH warned against the issue of ...
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https://en.wikipedia.org/wiki/Ayurveda
... well-designed clinical trials and systematic research reviews suggest that Ayurvedic approaches are effective". The NCCIH warned against the issue of ...
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84
Principles and Practice of Clinical Trials
https://books.google.com/books?id=1cB8EAAAQBAJ&pg=PA736&lpg=PA736&dq=multiplicity+issues+in+clinical+trials&source=bl&ots=TTeAkA8XrJ&sig=ACfU3U28SX8D-S-vyIjChK0Q1YbTqLZuJg&hl=en&sa=X&ved=2ahUKEwjZuqel5NH7AhXGpVYBHQAWAJMQ6AF6BQi3AhAD
Key Facts • Awareness is increasing for the need to identify and address multiplicity issues in confirmatory clinical trials. • There are many procedures ...
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https://books.google.com/books?id=1cB8EAAAQBAJ&pg=PA736&lpg=PA736&dq=multiplicity+issues+in+clinical+trials&source=bl&ots=TTeAkA8XrJ&sig=ACfU3U28SX8D-S-vyIjChK0Q1YbTqLZuJg&hl=en&sa=X&ved=2ahUKEwjZuqel5NH7AhXGpVYBHQAWAJMQ6AF6BQi3AhAD
Key Facts • Awareness is increasing for the need to identify and address multiplicity issues in confirmatory clinical trials. • There are many procedures ...
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85
Methods and Applications of Statistics in Clinical Trials, ...
https://books.google.com/books?id=QTEKAwAAQBAJ&pg=PT567&lpg=PT567&dq=multiplicity+issues+in+clinical+trials&source=bl&ots=_Abyn7uvQI&sig=ACfU3U0hiRT9PKXkAM-h70a-lhA1XbPdGA&hl=en&sa=X&ved=2ahUKEwjZuqel5NH7AhXGpVYBHQAWAJMQ6AF6BQi5AhAD
Multiplicity problems caused by multiple analyses performed on the same dataset occur frequently in a clinical trial setting. The following are examples of ...
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https://books.google.com/books?id=QTEKAwAAQBAJ&pg=PT567&lpg=PT567&dq=multiplicity+issues+in+clinical+trials&source=bl&ots=_Abyn7uvQI&sig=ACfU3U0hiRT9PKXkAM-h70a-lhA1XbPdGA&hl=en&sa=X&ved=2ahUKEwjZuqel5NH7AhXGpVYBHQAWAJMQ6AF6BQi5AhAD
Multiplicity problems caused by multiple analyses performed on the same dataset occur frequently in a clinical trial setting. The following are examples of ...
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86
Cancer Clinical Trials: Current and Controversial Issues in ...
https://books.google.com/books?id=qcLBDAAAQBAJ&pg=PA70&lpg=PA70&dq=multiplicity+issues+in+clinical+trials&source=bl&ots=q3sOCaVzGG&sig=ACfU3U09FfDyJhBQFZd1PmNq6dB58xOnqA&hl=en&sa=X&ved=2ahUKEwjZuqel5NH7AhXGpVYBHQAWAJMQ6AF6BQi4AhAD
This chapter describes statistical methods for addressing multiplicity issues faced in cancer clinical trials, with a focus on confirmatory phase III ...
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https://books.google.com/books?id=qcLBDAAAQBAJ&pg=PA70&lpg=PA70&dq=multiplicity+issues+in+clinical+trials&source=bl&ots=q3sOCaVzGG&sig=ACfU3U09FfDyJhBQFZd1PmNq6dB58xOnqA&hl=en&sa=X&ved=2ahUKEwjZuqel5NH7AhXGpVYBHQAWAJMQ6AF6BQi4AhAD
This chapter describes statistical methods for addressing multiplicity issues faced in cancer clinical trials, with a focus on confirmatory phase III ...
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87
Smith and Marx on Work - DiVA Portal
https://www.diva-portal.org/smash/get/diva2:1481671/FULLTEXT01.pdf
The problem is how Smith and Marx are set against each other on the traditional ... Smith's thought can be seen effected by multiplicity and combination of.
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https://www.diva-portal.org/smash/get/diva2:1481671/FULLTEXT01.pdf
The problem is how Smith and Marx are set against each other on the traditional ... Smith's thought can be seen effected by multiplicity and combination of.
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88
Interface between Regulation and Statistics in Drug Development
https://books.google.com/books?id=VB__DwAAQBAJ&pg=PT70&lpg=PT70&dq=multiplicity+issues+in+clinical+trials&source=bl&ots=Mf0VebMSja&sig=ACfU3U2JrMesKq2iYh8YNc6G5ndmO0SEBA&hl=en&sa=X&ved=2ahUKEwjZuqel5NH7AhXGpVYBHQAWAJMQ6AF6BQjIAhAD
... Traditional multiplicity adjustment methods in clinical trials . ... Medicines Agency ( 2017b ) Guideline on multiplicity issues in clinical trials .
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https://books.google.com/books?id=VB__DwAAQBAJ&pg=PT70&lpg=PT70&dq=multiplicity+issues+in+clinical+trials&source=bl&ots=Mf0VebMSja&sig=ACfU3U2JrMesKq2iYh8YNc6G5ndmO0SEBA&hl=en&sa=X&ved=2ahUKEwjZuqel5NH7AhXGpVYBHQAWAJMQ6AF6BQjIAhAD
... Traditional multiplicity adjustment methods in clinical trials . ... Medicines Agency ( 2017b ) Guideline on multiplicity issues in clinical trials .
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89
Multiple Testing Problems in Pharmaceutical Statistics
https://books.google.com/books?id=I_OA3tnnWqsC&pg=PA2&lpg=PA2&dq=multiplicity+issues+in+clinical+trials&source=bl&ots=bjpaFlOg3V&sig=ACfU3U3pyWg_siZpE0b-I_C9dcuHN5b_5g&hl=en&sa=X&ved=2ahUKEwjZuqel5NH7AhXGpVYBHQAWAJMQ6AF6BQirAhAD
This introductory chapter discusses multiplicity problems that commonly arise in confirmatory controlled clinical trials, and also briefly reviews new more ...
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https://books.google.com/books?id=I_OA3tnnWqsC&pg=PA2&lpg=PA2&dq=multiplicity+issues+in+clinical+trials&source=bl&ots=bjpaFlOg3V&sig=ACfU3U3pyWg_siZpE0b-I_C9dcuHN5b_5g&hl=en&sa=X&ved=2ahUKEwjZuqel5NH7AhXGpVYBHQAWAJMQ6AF6BQirAhAD
This introductory chapter discusses multiplicity problems that commonly arise in confirmatory controlled clinical trials, and also briefly reviews new more ...
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90
Group-Sequential Clinical Trials with Multiple Co-Objectives
https://books.google.com/books?id=S6ZPDAAAQBAJ&pg=PA13&lpg=PA13&dq=multiplicity+issues+in+clinical+trials&source=bl&ots=lmNW1ZQPr7&sig=ACfU3U0zZdbYku80zNmRVjTMWiuYDTVwdQ&hl=en&sa=X&ved=2ahUKEwjZuqel5NH7AhXGpVYBHQAWAJMQ6AF6BQi9AhAD
ContrClin Trials 21:313–329 Halperin M, DeMets DL, Ware JH (1990) Early ... R (2013) Multiplicity issues in clinical trials with multiple objectives.
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https://books.google.com/books?id=S6ZPDAAAQBAJ&pg=PA13&lpg=PA13&dq=multiplicity+issues+in+clinical+trials&source=bl&ots=lmNW1ZQPr7&sig=ACfU3U0zZdbYku80zNmRVjTMWiuYDTVwdQ&hl=en&sa=X&ved=2ahUKEwjZuqel5NH7AhXGpVYBHQAWAJMQ6AF6BQi9AhAD
ContrClin Trials 21:313–329 Halperin M, DeMets DL, Ware JH (1990) Early ... R (2013) Multiplicity issues in clinical trials with multiple objectives.
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