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Google Keyword Rankings for : hdac4 diabetes
1
HDAC4 mutations cause diabetes and induce β-cell FoxO1 ...
https://pubmed.ncbi.nlm.nih.gov/30968599/
Mutations in HDAC4 disrupt the deacetylation of FoxO1, subsequently decrease the β-cell function including insulin secretion, resulting in diabetes.
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https://pubmed.ncbi.nlm.nih.gov/30968599/
Mutations in HDAC4 disrupt the deacetylation of FoxO1, subsequently decrease the β-cell function including insulin secretion, resulting in diabetes.
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2
HDAC4 mutations cause diabetes and ... - Wiley Online Library
https://onlinelibrary.wiley.com/doi/full/10.1002/mgg3.602
HDAC4 mutations cause diabetes and induce β-cell FoxO1 nuclear exclusion ... About 3% of diabetic patients involve single-gene mutations ...
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https://onlinelibrary.wiley.com/doi/full/10.1002/mgg3.602
HDAC4 mutations cause diabetes and induce β-cell FoxO1 nuclear exclusion ... About 3% of diabetic patients involve single-gene mutations ...
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3
O-GlcNAcylation of Histone Deacetylase 4 Protects the ...
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.031942
In this study, we found that O-GlcNAcylation of HDAC4 at Ser-642 is cardio-protective in diabetes mellitus and counteracts pathological Ca2+/ ...
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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.031942
In this study, we found that O-GlcNAcylation of HDAC4 at Ser-642 is cardio-protective in diabetes mellitus and counteracts pathological Ca2+/ ...
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4
Specific Control of Pancreatic Endocrine β- and δ-Cell Mass ...
https://diabetesjournals.org/diabetes/article/60/11/2861/33446/Specific-Control-of-Pancreatic-Endocrine-and-Cell
Diabetes 2011;60(11):2861–2871 ... We show that class IIa HDAC4, -5, and -9 have an unexpected restricted expression in the endocrine β- and ...
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https://diabetesjournals.org/diabetes/article/60/11/2861/33446/Specific-Control-of-Pancreatic-Endocrine-and-Cell
Diabetes 2011;60(11):2861–2871 ... We show that class IIa HDAC4, -5, and -9 have an unexpected restricted expression in the endocrine β- and ...
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5
Histone deacetylase (HDAC) inhibition improves myocardial ...
https://cardiab.biomedcentral.com/articles/10.1186/s12933-015-0262-8
Both common forms of diabetes have an inflammatory pathogenesis in which immune and metabolic factors converge on interleukin-1β as a key ...
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https://cardiab.biomedcentral.com/articles/10.1186/s12933-015-0262-8
Both common forms of diabetes have an inflammatory pathogenesis in which immune and metabolic factors converge on interleukin-1β as a key ...
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6
Histone deacetylase 4 selectively contributes to podocyte ...
https://www.kidney-international.org/article/S0085-2538(15)30372-0/fulltext
Inhibitors of HDAC are a novel class of therapeutic agents in diabetic nephropathy, ... Thus, HDAC4 contributes to podocyte injury and is one of critical ...
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https://www.kidney-international.org/article/S0085-2538(15)30372-0/fulltext
Inhibitors of HDAC are a novel class of therapeutic agents in diabetic nephropathy, ... Thus, HDAC4 contributes to podocyte injury and is one of critical ...
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7
Histone deacetylase regulates insulin signaling via two ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184435
The involvement of epigenetic control in the onset of diabetes has also been ... HDAC4, 5, and 9 were reported to be involved in the ...
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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184435
The involvement of epigenetic control in the onset of diabetes has also been ... HDAC4, 5, and 9 were reported to be involved in the ...
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8
Histone Deacetylases in the Pathogenesis of Diabetic ...
https://www.frontiersin.org/articles/10.3389/fendo.2021.679655/full
HDAC inhibitors (HDACIs) are chemical compounds that block Zn2+-dependent HDAC enzymes involved in epigenetic modifications which regulate ...
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https://www.frontiersin.org/articles/10.3389/fendo.2021.679655/full
HDAC inhibitors (HDACIs) are chemical compounds that block Zn2+-dependent HDAC enzymes involved in epigenetic modifications which regulate ...
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9
HDAC4 mutations cause diabetes and induce β-cell FoxO1 nuclear ...
https://vivo.weill.cornell.edu/display/pubid30968599
METHODS: We performed exome sequencing in one adolescent nonautoimmune diabetic patient and detected one de novo predicted disease-causing HDAC4 variant (p.
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https://vivo.weill.cornell.edu/display/pubid30968599
METHODS: We performed exome sequencing in one adolescent nonautoimmune diabetic patient and detected one de novo predicted disease-causing HDAC4 variant (p.
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10
Role of histone deacetylase inhibitors in diabetic ...
https://www.spandidos-publications.com/10.3892/mi.2022.51/download
various combinations, such as HDaCIs, HDaC, diabetes, cardiomyopathy, heart failure and ischemia/reperfusion injury, were used.
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https://www.spandidos-publications.com/10.3892/mi.2022.51/download
various combinations, such as HDaCIs, HDaC, diabetes, cardiomyopathy, heart failure and ischemia/reperfusion injury, were used.
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11
Histone Deacetylase 9 - Diabetes & Metabolism Journal
https://www.e-dmj.org/journal/view.php?number=724
Based on the role of HDAC in chromatin remodeling, HDAC9 is generally considered as a negative regulator of gene transcription. It was shown ...
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https://www.e-dmj.org/journal/view.php?number=724
Based on the role of HDAC in chromatin remodeling, HDAC9 is generally considered as a negative regulator of gene transcription. It was shown ...
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12
HDAC4 mutations cause diabetes and induce β‐cell FoxO1 ...
https://edoc.mdc-berlin.de/18155/1/18155oa.pdf
About 3% of diabetic patients involve single‐gene mutations ... KEYWORDS diabetes, FoxO1, HDAC4 mutations, pancreatic β‐cells ...
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https://edoc.mdc-berlin.de/18155/1/18155oa.pdf
About 3% of diabetic patients involve single‐gene mutations ... KEYWORDS diabetes, FoxO1, HDAC4 mutations, pancreatic β‐cells ...
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13
Cyclo-RGD Truncated Polymeric Nanoconstruct with ...
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.0c00094
Diabetic nephropathy (DN), a chronic progressive kidney disease, ... for Targeted HDAC4 Gene Silencing in a Diabetic Nephropathy Mouse Model.
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https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.0c00094
Diabetic nephropathy (DN), a chronic progressive kidney disease, ... for Targeted HDAC4 Gene Silencing in a Diabetic Nephropathy Mouse Model.
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14
The Emerging Role of HDACs: Pathology and Therapeutic ...
https://www.mdpi.com/2073-4409/10/6/1340/htm
HDAC-Mediated Therapeutic Options in Diabetic Cardiomyopathy. High glucose-induced oxidative stress, AGEs accumulation, inflammation, ER stress, apoptosis and a ...
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https://www.mdpi.com/2073-4409/10/6/1340/htm
HDAC-Mediated Therapeutic Options in Diabetic Cardiomyopathy. High glucose-induced oxidative stress, AGEs accumulation, inflammation, ER stress, apoptosis and a ...
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15
Class IIa HDACs do not influence beta-cell function under ...
https://www.tandfonline.com/doi/full/10.1080/19382014.2019.1617621
Inhibiting Class IIa Histone Deacetylase (HDAC) function is a ... One area of research within type 2 diabetes, specifically insulin ...
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https://www.tandfonline.com/doi/full/10.1080/19382014.2019.1617621
Inhibiting Class IIa Histone Deacetylase (HDAC) function is a ... One area of research within type 2 diabetes, specifically insulin ...
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16
Role of HDAC inhibitors in diabetes mellitus - Read by QxMD
https://read.qxmd.com/read/31477543/role-of-hdac-inhibitors-in-diabetes-mellitus
KEY FINDINGS: Through recent studies and reports the role of various epigenetic markers in treatment of diabetes mellitus has been revealed. HDAC enzyme ...
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https://read.qxmd.com/read/31477543/role-of-hdac-inhibitors-in-diabetes-mellitus
KEY FINDINGS: Through recent studies and reports the role of various epigenetic markers in treatment of diabetes mellitus has been revealed. HDAC enzyme ...
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17
Histone deacetylases 1 and 3 but not 2 mediate cytokine ...
https://link.springer.com/article/10.1007/s00125-012-2615-0
Beta cell function in type 1 diabetes of recent onset can be ... HDAC expression in pancreatic islets from non-diabetic subjects and ...
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https://link.springer.com/article/10.1007/s00125-012-2615-0
Beta cell function in type 1 diabetes of recent onset can be ... HDAC expression in pancreatic islets from non-diabetic subjects and ...
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18
HDAC4 Mutations Cause Diabetes and Induce β ... - ESPE Abstracts
https://abstracts.eurospe.org/hrp/0092/hrp0092fc15.2
HDAC4 Mutations Cause Diabetes and Induce β-Cell FoxO1 Nuclear Exclusion ... sequencing in one adolescent boy with non-autoimmune diabetes and his parents.
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https://abstracts.eurospe.org/hrp/0092/hrp0092fc15.2
HDAC4 Mutations Cause Diabetes and Induce β-Cell FoxO1 Nuclear Exclusion ... sequencing in one adolescent boy with non-autoimmune diabetes and his parents.
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19
Histone deacetylase-2 is a key regulator of diabetes
https://journals.physiology.org/doi/full/10.1152/ajprenal.00086.2009
This study examined the effect of HDAC inhibition on renal fibrosis induced by diabetes or transforming growth factor (TGF)-β1 and determined the role of ...
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https://journals.physiology.org/doi/full/10.1152/ajprenal.00086.2009
This study examined the effect of HDAC inhibition on renal fibrosis induced by diabetes or transforming growth factor (TGF)-β1 and determined the role of ...
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20
[PDF] HDAC4 mutations cause diabetes and induce β‐cell ...
https://www.researchgate.net/publication/332324911_HDAC4_mutations_cause_diabetes_and_induce_b-cell_FoxO1_nuclear_exclusion
Methods We performed exome sequencing in one adolescent nonautoimmune diabetic patient and detected one de novo predicted disease‐causing HDAC4 variant (p.
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https://www.researchgate.net/publication/332324911_HDAC4_mutations_cause_diabetes_and_induce_b-cell_FoxO1_nuclear_exclusion
Methods We performed exome sequencing in one adolescent nonautoimmune diabetic patient and detected one de novo predicted disease‐causing HDAC4 variant (p.
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21
(PDF) HDAC4 mutations cause diabetes and induce β-cell FoxO1 ...
https://typeset.io/papers/hdac4-mutations-cause-diabetes-and-induce-b-cell-foxo1-ibhigb5jif
Methods We performed exome sequencing in one adolescent nonautoimmune diabetic patient and detected one de novo predicted disease-causing HDAC4 variant (p.
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https://typeset.io/papers/hdac4-mutations-cause-diabetes-and-induce-b-cell-foxo1-ibhigb5jif
Methods We performed exome sequencing in one adolescent nonautoimmune diabetic patient and detected one de novo predicted disease-causing HDAC4 variant (p.
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22
MicroRNA-29a Promotion of Nephrin Acetylation Ameliorates ...
https://jasn.asnjournals.org/content/25/8/1698
HDAC4, via epigenetic H3K9 hypoacetylation, reduces miR-29a transcription. The renoprotective effects of miR-29a in diabetes-induced loss of podocyte integrity ...
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https://jasn.asnjournals.org/content/25/8/1698
HDAC4, via epigenetic H3K9 hypoacetylation, reduces miR-29a transcription. The renoprotective effects of miR-29a in diabetes-induced loss of podocyte integrity ...
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23
Suppression of HDAC by sodium acetate rectifies cardiac ...
https://journals.sagepub.com/doi/full/10.1177/1535370220913847
Diabetes mellitus, particularly type 2 occurs at global epidemic proportions and leads to cardiovascular diseases.
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https://journals.sagepub.com/doi/full/10.1177/1535370220913847
Diabetes mellitus, particularly type 2 occurs at global epidemic proportions and leads to cardiovascular diseases.
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24
Search Human Diseases - [el] HDAC4 - MalaCards
https://www.malacards.org/search/eliteGene/HDAC4
Search results for [el] HDAC4. 2 hits were found for [el] HDAC4. #, Family, MCID, Name, MIFTS, Score. 1. CHR543, Chromosome 2q37 Deletion Syndrome, 45 ...
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https://www.malacards.org/search/eliteGene/HDAC4
Search results for [el] HDAC4. 2 hits were found for [el] HDAC4. #, Family, MCID, Name, MIFTS, Score. 1. CHR543, Chromosome 2q37 Deletion Syndrome, 45 ...
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25
642 determine whether diabetes harms or protects the heart
https://dgk.org/kongress_programme/jt2019/aV1381.html
This “diabetic paradox” raises the question whether and how glucose mediates protective versus maladaptive effects. Histone deacetylase 4 (HDAC4) and its ...
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https://dgk.org/kongress_programme/jt2019/aV1381.html
This “diabetic paradox” raises the question whether and how glucose mediates protective versus maladaptive effects. Histone deacetylase 4 (HDAC4) and its ...
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26
Cell Signaling - UCSD School of Medicine
https://medschool.ucsd.edu/som/medicine/divisions/endocrinology/research/diabetes-research-center/research/Pages/Cell-Signaling.aspx
Diabetes Research Center ... catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4, by DRC members Montminy, Shaw, ...
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https://medschool.ucsd.edu/som/medicine/divisions/endocrinology/research/diabetes-research-center/research/Pages/Cell-Signaling.aspx
Diabetes Research Center ... catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4, by DRC members Montminy, Shaw, ...
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27
P2841Cardiac-selective targeting of histone deacetylase 4 to ...
https://academic.oup.com/eurheartj/article/39/suppl_1/ehy565.P2841/5084290
Purpose: To investigate the impact of inhibiting HDAC4 via a cardiac-targeted gene therapeutic approach on the progression of diabetic ...
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https://academic.oup.com/eurheartj/article/39/suppl_1/ehy565.P2841/5084290
Purpose: To investigate the impact of inhibiting HDAC4 via a cardiac-targeted gene therapeutic approach on the progression of diabetic ...
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28
Cyclo-RGD Truncated Polymeric Nanoconstruct with ...
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3454943
Diabetic Nephropathy (DN), a chronic progressive kidney disease, ... for Targeted HDAC4 Gene Silencing in Diabetic Nephropathy Mouse Model.
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https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3454943
Diabetic Nephropathy (DN), a chronic progressive kidney disease, ... for Targeted HDAC4 Gene Silencing in Diabetic Nephropathy Mouse Model.
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29
Histone deacetylase 4 interacts with 53BP1 to mediate the ...
https://rupress.org/jcb/article-abstract/160/7/1017/33202
HDAC4 foci gradually disappeared in repair-proficient cells but persisted in repair-deficient cell lines or cells irradiated with a lethal dose, suggesting that ...
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https://rupress.org/jcb/article-abstract/160/7/1017/33202
HDAC4 foci gradually disappeared in repair-proficient cells but persisted in repair-deficient cell lines or cells irradiated with a lethal dose, suggesting that ...
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30
Researchers Identify HDACs as Potential Targets for Type 2 ...
https://www.genengnews.com/news/researchers-identify-hdacs-as-potential-targets-for-type-2-diabetes/
Team showed that blocking HDACs in diabetic mice restored normal glucose ... When they then simultaneously blocked the production of HDAC4, ...
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https://www.genengnews.com/news/researchers-identify-hdacs-as-potential-targets-for-type-2-diabetes/
Team showed that blocking HDACs in diabetic mice restored normal glucose ... When they then simultaneously blocked the production of HDAC4, ...
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31
From molecular promise to preclinical results: HDAC inhibitors ...
https://www.embopress.org/doi/10.15252/emmm.201809854
We describe the theories of how classical HDAC inhibitors may ... diabetes to sarcopenia, which show improvement upon HDAC inhibition.
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https://www.embopress.org/doi/10.15252/emmm.201809854
We describe the theories of how classical HDAC inhibitors may ... diabetes to sarcopenia, which show improvement upon HDAC inhibition.
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32
Hepatocyte DACH1 Is Increased in Obesity via Nuclear ...
https://diabetescenters.org/bibcite/reference/140
Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 ... Defective insulin signaling in hepatocytes is a key factor in type 2 diabetes.
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https://diabetescenters.org/bibcite/reference/140
Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 ... Defective insulin signaling in hepatocytes is a key factor in type 2 diabetes.
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33
contribution of histone deacetylases and ER stress inhibition
https://tahomaclinic.com/Private/Articles4/PhenylbutyricAcid/Khan%202017%20-%20Phenylbutyrate%20and%20Beta-cell%20function.pdf
Keywords: β-cell • diabetes • ER stress • HDAC inhibition • phenylbutyrate. Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia ...
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https://tahomaclinic.com/Private/Articles4/PhenylbutyricAcid/Khan%202017%20-%20Phenylbutyrate%20and%20Beta-cell%20function.pdf
Keywords: β-cell • diabetes • ER stress • HDAC inhibition • phenylbutyrate. Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia ...
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34
The Role of Histone Deacetylases in GlucoseMetabolism: a Mini
https://www.sciforschenonline.org/journals/endocrinology/article-data/IJEMD-1-113/IJEMD-1-113.pdf
cells, which play a significant role in diabetes. HDAC II (HDAC4, HDAC5 and HDAC9) regulates differentiation and development of the ...
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https://www.sciforschenonline.org/journals/endocrinology/article-data/IJEMD-1-113/IJEMD-1-113.pdf
cells, which play a significant role in diabetes. HDAC II (HDAC4, HDAC5 and HDAC9) regulates differentiation and development of the ...
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35
Hdac4 (histone deacetylase 4) - Rat Genome Database
https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=619979
... Diabetic Nephropathies; Experimental Diabetes Mellitus; FOUND IN A band; cytoplasm; cytosol; ... Gene: Hdac4 (histone deacetylase 4) Rattus norvegicus.
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https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=619979
... Diabetic Nephropathies; Experimental Diabetes Mellitus; FOUND IN A band; cytoplasm; cytosol; ... Gene: Hdac4 (histone deacetylase 4) Rattus norvegicus.
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36
HDAC4 mutations cause diabetes and induce β‐cell FoxO1 nuclear ...
https://www.researcher-app.com/paper/2653895
We performed exome sequencing in one adolescent nonautoimmune diabetic patient and detected one de novo predicted disease‐causing HDAC4 variant (p.His227Arg).
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https://www.researcher-app.com/paper/2653895
We performed exome sequencing in one adolescent nonautoimmune diabetic patient and detected one de novo predicted disease‐causing HDAC4 variant (p.His227Arg).
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37
SIK2 regulates CRTCs, HDAC4 and glucose uptake in ...
https://www.ludc.lu.se/karin-stenkula/publication/603ddd36-db24-40ac-8288-bde125fb5ec6
Protein Phosphorylation · EXODIAB: Excellence of Diabetes Research in Sweden · Glucose Transport and Protein Trafficking · Surgery (Lund) · Insulin Signal ...
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https://www.ludc.lu.se/karin-stenkula/publication/603ddd36-db24-40ac-8288-bde125fb5ec6
Protein Phosphorylation · EXODIAB: Excellence of Diabetes Research in Sweden · Glucose Transport and Protein Trafficking · Surgery (Lund) · Insulin Signal ...
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38
SP1 Promotes HDAC4 Expression and Inhibits HMGB1 ...
https://www.karger.com/Article/FullText/518277
HDAC4, a class IIa histone deacetylase, is implicated in the regulation of gene ... of human lens epithelial cells via p38MAPK pathway in diabetic cataract.
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https://www.karger.com/Article/FullText/518277
HDAC4, a class IIa histone deacetylase, is implicated in the regulation of gene ... of human lens epithelial cells via p38MAPK pathway in diabetic cataract.
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39
Diabetic Nephropathy: Pathophysiology and Clinical Aspects
https://books.google.com/books?id=joB1DwAAQBAJ&pg=PA177&lpg=PA177&dq=hdac4+diabetes&source=bl&ots=JUV3yPHOL4&sig=ACfU3U0RsPA5zJGzaBlgsnPWsZYa3Po5rg&hl=en&sa=X&ved=2ahUKEwip7rrDtNL7AhW6jIkEHYg2DMIQ6AF6BQj4ARAD
HDAC proteins have been shown to also have non-epigenetic roles in regulating ... HDAC4 expression is upregulated in streptozotocin-induced diabetic rats, ...
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https://books.google.com/books?id=joB1DwAAQBAJ&pg=PA177&lpg=PA177&dq=hdac4+diabetes&source=bl&ots=JUV3yPHOL4&sig=ACfU3U0RsPA5zJGzaBlgsnPWsZYa3Po5rg&hl=en&sa=X&ved=2ahUKEwip7rrDtNL7AhW6jIkEHYg2DMIQ6AF6BQj4ARAD
HDAC proteins have been shown to also have non-epigenetic roles in regulating ... HDAC4 expression is upregulated in streptozotocin-induced diabetic rats, ...
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40
Pathology and Therapeutic targets in Diabetes Mellitus
https://www.preprints.org/manuscript/202104.0742/v1/download
Functionally, most of the HDAC isoforms can regulate β cell fate, insulin release, insulin expression and signaling, and glucose metabolism.
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https://www.preprints.org/manuscript/202104.0742/v1/download
Functionally, most of the HDAC isoforms can regulate β cell fate, insulin release, insulin expression and signaling, and glucose metabolism.
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41
Histone deacetylases in cardiovascular and metabolic diseases
https://www.jmcc-online.com/article/S0022-2828(18)31232-X/fulltext
... HDAC inhibitors may prove to be powerful therapeutic agents for the treatment of cardiovascular diseases, obesity and diabetes.
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https://www.jmcc-online.com/article/S0022-2828(18)31232-X/fulltext
... HDAC inhibitors may prove to be powerful therapeutic agents for the treatment of cardiovascular diseases, obesity and diabetes.
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42
Histone deacetylase HDAC4 participates in the pathological ...
https://www.nature.com/articles/s41420-021-00601-1
Meanwhile, HDAC4 silencing promoted the expression of miR-206, ... Platelets, diabetes and myocardial ischemia/reperfusion injury.
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https://www.nature.com/articles/s41420-021-00601-1
Meanwhile, HDAC4 silencing promoted the expression of miR-206, ... Platelets, diabetes and myocardial ischemia/reperfusion injury.
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43
In Vivo Chromatin Remodeling Events Leading to ...
https://www.jbc.org/article/S0021-9258(19)75647-6/pdf
tions mimicking diabetes can activate the transcription of NF- B-regulated inflammatory genes. ... HDAC1, HDAC4, HDAC5, and HDAC6 were from Dr. S. Schreiber.
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https://www.jbc.org/article/S0021-9258(19)75647-6/pdf
tions mimicking diabetes can activate the transcription of NF- B-regulated inflammatory genes. ... HDAC1, HDAC4, HDAC5, and HDAC6 were from Dr. S. Schreiber.
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44
Specific Control of Pancreatic Endocrine β- and δ-Cell Mass ...
https://hal.archives-ouvertes.fr/hal-03832421/
Analyses of the pancreas of class IIa HDAC mutant mice revealed an increased pool ... Conversely, HDAC4 and HDAC5 overexpression showed a decreased pool of ...
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https://hal.archives-ouvertes.fr/hal-03832421/
Analyses of the pancreas of class IIa HDAC mutant mice revealed an increased pool ... Conversely, HDAC4 and HDAC5 overexpression showed a decreased pool of ...
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45
The dark side of HDAC inhibition in ALS - The Lancet
https://www.thelancet.com/article/S2352-3964(19)30117-3/fulltext
In this article of EBioMedicine, Viviana Moresi and colleagues provide genetic evidence that skeletal muscle HDAC4 exerts a protective role ...
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https://www.thelancet.com/article/S2352-3964(19)30117-3/fulltext
In this article of EBioMedicine, Viviana Moresi and colleagues provide genetic evidence that skeletal muscle HDAC4 exerts a protective role ...
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46
WO2017075192A1 - Hdac inhibitors for the treatment of ...
https://patents.google.com/patent/WO2017075192A1/en
The invention relates to HDAC inhibitors for use in the treatment of diabetic peripheral neuropathy in a subject in need thereof. Also provided herein are ...
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https://patents.google.com/patent/WO2017075192A1/en
The invention relates to HDAC inhibitors for use in the treatment of diabetic peripheral neuropathy in a subject in need thereof. Also provided herein are ...
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47
Resveratrol affects hepatic gluconeogenesis via histone ...
https://www.dovepress.com/resveratrol-affects-hepatic-gluconeogenesis-via-histone-deacetylase-4-peer-reviewed-fulltext-article-DMSO
Thus, the control level of diabetes or insulin resistance is low. ... Effects of resveratrol on the gluconeogenesis pathway and HDAC4 ...
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https://www.dovepress.com/resveratrol-affects-hepatic-gluconeogenesis-via-histone-deacetylase-4-peer-reviewed-fulltext-article-DMSO
Thus, the control level of diabetes or insulin resistance is low. ... Effects of resveratrol on the gluconeogenesis pathway and HDAC4 ...
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48
HDAC4 controls histone methylation in response to elevated ...
https://www.jci.org/articles/view/61084
Using human LV myocardium, we found that, despite nuclear export of histone deacetylase 4 (HDAC4), upregulation of ANP and BNP in failing ...
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https://www.jci.org/articles/view/61084
Using human LV myocardium, we found that, despite nuclear export of histone deacetylase 4 (HDAC4), upregulation of ANP and BNP in failing ...
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49
Anti-HDAC4 antibody (ab12172) - Abcam
https://www.abcam.com/hdac4-antibody-ab12172.html
Rabbit polyclonal HDAC4 antibody. Validated in WB, IP, ICC/IF and tested in Mouse, Rat, Human. Cited in 21 publication(s). Independently reviewed in 7 ...
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https://www.abcam.com/hdac4-antibody-ab12172.html
Rabbit polyclonal HDAC4 antibody. Validated in WB, IP, ICC/IF and tested in Mouse, Rat, Human. Cited in 21 publication(s). Independently reviewed in 7 ...
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50
Metabolic homeostasis: regulation of FOXO by class IIa HDACs
https://www.qiagen.com/us/spotlight-pages/newsletters-and-magazines/articles/reviews-online-metabolic-homeostasis/
Recent discovery of the role of class IIa HDAC activity in regulation of glucose ... a strategy for treatment of metabolic disorders such as type 2 diabetes.
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https://www.qiagen.com/us/spotlight-pages/newsletters-and-magazines/articles/reviews-online-metabolic-homeostasis/
Recent discovery of the role of class IIa HDAC activity in regulation of glucose ... a strategy for treatment of metabolic disorders such as type 2 diabetes.
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51
Epigenetic modulation of selected immune response genes ...
https://www.biorxiv.org/content/10.1101/2021.07.15.452572v2.full.pdf
HDAC, histone deacetylase; qRT-PCR, quantitative reverse transcriptase-mediated polymerase chain reaction; T1D, type 1 diabetes; Th, ...
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https://www.biorxiv.org/content/10.1101/2021.07.15.452572v2.full.pdf
HDAC, histone deacetylase; qRT-PCR, quantitative reverse transcriptase-mediated polymerase chain reaction; T1D, type 1 diabetes; Th, ...
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52
Post-translational Modifications Regulate Class IIa Histone ...
https://www.mcponline.org/article/S1535-9476(20)33214-X/pdf
vascular hypertrophy, atherosclerosis, cancer, and diabetes. With several HDAC inhibitors in phase I and II clinical trials,.
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https://www.mcponline.org/article/S1535-9476(20)33214-X/pdf
vascular hypertrophy, atherosclerosis, cancer, and diabetes. With several HDAC inhibitors in phase I and II clinical trials,.
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53
Role of Phosphorylated HDAC4 in Stroke-Induced Angiogenesis
https://www.hindawi.com/journals/bmri/2017/2957538/
Phosphorylation of HDAC4 was also increased in endothelial cells hypoxia model and ... G. E. H. M. Rutten, and L. J. Kappelle, “Diabetes, hyperglycaemia, ...
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https://www.hindawi.com/journals/bmri/2017/2957538/
Phosphorylation of HDAC4 was also increased in endothelial cells hypoxia model and ... G. E. H. M. Rutten, and L. J. Kappelle, “Diabetes, hyperglycaemia, ...
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54
SIK2 regulates CRTCs, HDAC4 and glucose uptake in ...
https://journals.biologists.com/jcs/article/128/3/472/55359/SIK2-regulates-CRTCs-HDAC4-and-glucose-uptake-in
We also describe a SIK2–CRTC2–HDAC4 pathway and its regulation in human adipocytes ... The Swedish Diabetes Association; Thuring Foundation; Magnus Bergvall ...
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https://journals.biologists.com/jcs/article/128/3/472/55359/SIK2-regulates-CRTCs-HDAC4-and-glucose-uptake-in
We also describe a SIK2–CRTC2–HDAC4 pathway and its regulation in human adipocytes ... The Swedish Diabetes Association; Thuring Foundation; Magnus Bergvall ...
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55
Epigenetic modification and therapeutic targets of diabetes ...
https://portlandpress.com/bioscirep/article/40/9/BSR20202160/226148/Epigenetic-modification-and-therapeutic-targets-of
This complex can be dissociated by applying HDAC inhibitor (Trichostatin) reversal the Pdx1 silencing [72]. DNA methylation. The important mechanism involved in ...
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https://portlandpress.com/bioscirep/article/40/9/BSR20202160/226148/Epigenetic-modification-and-therapeutic-targets-of
This complex can be dissociated by applying HDAC inhibitor (Trichostatin) reversal the Pdx1 silencing [72]. DNA methylation. The important mechanism involved in ...
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56
HDAC1 Human Histone Deacetylase (HDAC) Enzymatic ...
https://www.eurofinsdiscoveryservices.com/catalogmanagement/viewitem/HDAC1-Human-Histone-Deacetylase-HDAC-Enzymatic-Assay-Cerep/2491
The human HDAC proteins are organized into classes based on their similarity to yeast HDAC proteins. Class I HDACs include HDAC1, HDAC2, HDAC3, and HDAC8, which ...
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https://www.eurofinsdiscoveryservices.com/catalogmanagement/viewitem/HDAC1-Human-Histone-Deacetylase-HDAC-Enzymatic-Assay-Cerep/2491
The human HDAC proteins are organized into classes based on their similarity to yeast HDAC proteins. Class I HDACs include HDAC1, HDAC2, HDAC3, and HDAC8, which ...
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57
The HDAC Inhibitor Butyrate Impairs β Cell Function ... - MDPI
https://mdpi-res.com/d_attachment/ijms/ijms-22-13330/article_deploy/ijms-22-13330.pdf?version=1639214915
diabetes risk and protect insulin-secreting pancreatic β cells in ... Keywords: HDAC inhibitors; butyrate; diabetes; insulin secretion; ...
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https://mdpi-res.com/d_attachment/ijms/ijms-22-13330/article_deploy/ijms-22-13330.pdf?version=1639214915
diabetes risk and protect insulin-secreting pancreatic β cells in ... Keywords: HDAC inhibitors; butyrate; diabetes; insulin secretion; ...
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58
Epigenetics in Human Disease - Page 500 - Google Books Result
https://books.google.com/books?id=QSxHDwAAQBAJ&pg=PA500&lpg=PA500&dq=hdac4+diabetes&source=bl&ots=GdzuCDZF2k&sig=ACfU3U3enKh8bbbFyoDiQqHqUC0o9DCOgg&hl=en&sa=X&ved=2ahUKEwip7rrDtNL7AhW6jIkEHYg2DMIQ6AF6BQj5ARAD
HDAC Isoform HDAC2 HDAC3 HDAC4 HDAC9 Sirt1 Sirt2 ... Evidence to Support a Role for This HDAC in Diabetes Pathogenesis HDAC2 activity was significantly ...
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https://books.google.com/books?id=QSxHDwAAQBAJ&pg=PA500&lpg=PA500&dq=hdac4+diabetes&source=bl&ots=GdzuCDZF2k&sig=ACfU3U3enKh8bbbFyoDiQqHqUC0o9DCOgg&hl=en&sa=X&ved=2ahUKEwip7rrDtNL7AhW6jIkEHYg2DMIQ6AF6BQj5ARAD
HDAC Isoform HDAC2 HDAC3 HDAC4 HDAC9 Sirt1 Sirt2 ... Evidence to Support a Role for This HDAC in Diabetes Pathogenesis HDAC2 activity was significantly ...
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59
Proteomic analysis of human obesity reveals differential expression ...
https://www.iomcworld.com/proceedings/proteomic-analysis-of-human-obesity-reveals-differential-expression-of-the-epigenetic-factor-hdac4-and-role-of-physical-exercise-in-correcting-its-exp-23339.html
... expression of the epigenetic factor HDAC4 and role of physical exercise in correcting its expression. 4th World Congress on Diabetes & Metabolism
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https://www.iomcworld.com/proceedings/proteomic-analysis-of-human-obesity-reveals-differential-expression-of-the-epigenetic-factor-hdac4-and-role-of-physical-exercise-in-correcting-its-exp-23339.html
... expression of the epigenetic factor HDAC4 and role of physical exercise in correcting its expression. 4th World Congress on Diabetes & Metabolism
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60
Class IIa HDACs do not influence beta-cell function under ...
https://dro.deakin.edu.au/ndownloader/files/36993631
Histone deacetylase; diabetes; HDAC-4; HDAC-5; glucotoxicity; beta cells. Introduction. Diabetes is characterised by two defects based.
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https://dro.deakin.edu.au/ndownloader/files/36993631
Histone deacetylase; diabetes; HDAC-4; HDAC-5; glucotoxicity; beta cells. Introduction. Diabetes is characterised by two defects based.
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61
HDAC7 is overexpressed in human diabetic islets and impairs ...
https://d-nb.info/1120128080/34
drial functional analyses, microarray techniques, and HDAC ... expression in human pancreatic islets from type 2 diabetic com-.
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https://d-nb.info/1120128080/34
drial functional analyses, microarray techniques, and HDAC ... expression in human pancreatic islets from type 2 diabetic com-.
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62
Phase I of Histone Deacetylase (HDAC) Inhibitor Panobinostat ...
https://clinicaltrials.gov/ct2/show/NCT02032810
Diabetes mellitus uncontrolled by medication; Known drug or alcohol abuse; Presence of underlying medical condition that in the opinion of the Investigator or ...
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https://clinicaltrials.gov/ct2/show/NCT02032810
Diabetes mellitus uncontrolled by medication; Known drug or alcohol abuse; Presence of underlying medical condition that in the opinion of the Investigator or ...
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63
Mechanisms of Vascular Defects in Diabetes Mellitus
https://books.google.com/books?id=i1ovDwAAQBAJ&pg=PA331&lpg=PA331&dq=hdac4+diabetes&source=bl&ots=Q5j8mDbl9c&sig=ACfU3U24TNsoaKci2ngDAewdwXA8-33KCQ&hl=en&sa=X&ved=2ahUKEwip7rrDtNL7AhW6jIkEHYg2DMIQ6AF6BQiHAhAD
14.3.3.5 Class IV HDACs The Class IV HDAC (HDAC11) has sequence similarity to Class I and II HDACs. Aside from this, little is known of its function and ...
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https://books.google.com/books?id=i1ovDwAAQBAJ&pg=PA331&lpg=PA331&dq=hdac4+diabetes&source=bl&ots=Q5j8mDbl9c&sig=ACfU3U24TNsoaKci2ngDAewdwXA8-33KCQ&hl=en&sa=X&ved=2ahUKEwip7rrDtNL7AhW6jIkEHYg2DMIQ6AF6BQiHAhAD
14.3.3.5 Class IV HDACs The Class IV HDAC (HDAC11) has sequence similarity to Class I and II HDACs. Aside from this, little is known of its function and ...
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64
Brachydactyly mental retardation syndrome with growth ...
https://edm.bioscientifica.com/view/journals/edm/2018/1/EDM18-0068.xml
Citation: Endocrinology, Diabetes & Metabolism Case Reports 2018, 1; 10.1530/EDM-18- ... Haploinsufficiency of HDAC4 causes brachydactyly mental retardation ...
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https://edm.bioscientifica.com/view/journals/edm/2018/1/EDM18-0068.xml
Citation: Endocrinology, Diabetes & Metabolism Case Reports 2018, 1; 10.1530/EDM-18- ... Haploinsufficiency of HDAC4 causes brachydactyly mental retardation ...
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65
Skeletal muscle denervation causes skeletal muscle atrophy ...
https://iro.uiowa.edu/discovery/fulldisplay?docid=alma9984025569202771&context=L&vid=01IOWA_INST:ResearchRepository&lang=en&search_scope=Research&adaptor=Local%20Search%20Engine&tab=Research&query=sub%2Cexact%2Chistone%20deacetylase%2CAND&mode=advanced
Conversely, forced expression of HDAC4 is sufficient to increase skeletal muscle ... and Biophysics and Fraternal Order of Eagles Diabetes Research Center, ...
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https://iro.uiowa.edu/discovery/fulldisplay?docid=alma9984025569202771&context=L&vid=01IOWA_INST:ResearchRepository&lang=en&search_scope=Research&adaptor=Local%20Search%20Engine&tab=Research&query=sub%2Cexact%2Chistone%20deacetylase%2CAND&mode=advanced
Conversely, forced expression of HDAC4 is sufficient to increase skeletal muscle ... and Biophysics and Fraternal Order of Eagles Diabetes Research Center, ...
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66
(PDF) Proteomics Analysis of Human Obesity Reveals the ...
https://www.academia.edu/18002767/Proteomics_Analysis_of_Human_Obesity_Reveals_the_Epigenetic_Factor_HDAC4_as_a_Potential_Target_for_Obesity
Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4 as a ... of insulin resistance, type β diabetes and cardiovascular diseases.
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https://www.academia.edu/18002767/Proteomics_Analysis_of_Human_Obesity_Reveals_the_Epigenetic_Factor_HDAC4_as_a_Potential_Target_for_Obesity
Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4 as a ... of insulin resistance, type β diabetes and cardiovascular diseases.
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67
Abstract 443: Class I Histone Deacetylases Mediate Cardiac I ...
https://oa.mg/work/10.1161/res.119.suppl_1.443
This study emphasizes the importance of exploring class I HDAC inhibitors for ... Mitochondrial Complex I During Ischemia/reperfusion Injury in Diabetes.
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https://oa.mg/work/10.1161/res.119.suppl_1.443
This study emphasizes the importance of exploring class I HDAC inhibitors for ... Mitochondrial Complex I During Ischemia/reperfusion Injury in Diabetes.
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68
Histone deacetylatse (HDAC) inhibitors - YouTube
https://www.youtube.com/watch?v=OBcpk-M5RYE
Apr 4, 2017
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https://www.youtube.com/watch?v=OBcpk-M5RYE
Apr 4, 2017
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69
Diabetes Medications and Support Programs - Eli Lilly
https://www.lilly.com/disease-areas/diabetes
For more than 90 years, Lilly has been committed to diabetes and meeting the needs of people affected by diabetes with treatment options, support programs ...
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https://www.lilly.com/disease-areas/diabetes
For more than 90 years, Lilly has been committed to diabetes and meeting the needs of people affected by diabetes with treatment options, support programs ...
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70
<i>HDAC4</i> mutations cause diabetes and induce β‐cell FoxO1 ...
https://ur.booksc.eu/book/75274137/35dddc
HDAC4 mutations cause diabetes and induce β‐cell FoxO1 nuclear exclusion | Gong, Maolian; Yu, Yong; Liang, Lei; Vuralli, Dogus; Froehler, Sebastian; ...
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https://ur.booksc.eu/book/75274137/35dddc
HDAC4 mutations cause diabetes and induce β‐cell FoxO1 nuclear exclusion | Gong, Maolian; Yu, Yong; Liang, Lei; Vuralli, Dogus; Froehler, Sebastian; ...
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71
Cellular Defect Linked to Diabetes
https://www.cuimc.columbia.edu/news/cellular-defect-linked-diabetes
Cellular Defect Linked to Diabetes. Leaky calcium channels in pancreatic beta cells can lead to high blood sugar. News.
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https://www.cuimc.columbia.edu/news/cellular-defect-linked-diabetes
Cellular Defect Linked to Diabetes. Leaky calcium channels in pancreatic beta cells can lead to high blood sugar. News.
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72
Molecule May Be Key to Pain Relief in Diabetic Neuropathy
https://news.feinberg.northwestern.edu/2018/04/26/molecule-may-be-key-to-pain-relief-in-diabetic-neuropathy/
Painful diabetic neuropathy (PDN) is caused by hyper-excitable nociceptors, and patients suffer severe pain while nerves in the skin degenerate.
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https://news.feinberg.northwestern.edu/2018/04/26/molecule-may-be-key-to-pain-relief-in-diabetic-neuropathy/
Painful diabetic neuropathy (PDN) is caused by hyper-excitable nociceptors, and patients suffer severe pain while nerves in the skin degenerate.
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73
Diabetes study could hold cure to disease | wnep.com
https://www.wnep.com/article/news/local/susquehanna-county/diabetes-study-could-hold-cure-to-disease-type-1/523-fae59b59-7e4e-4dba-a7d7-6537086a9a3e
Doctors say Type 1 Diabetes often develops in childhood. The disease destroys insulin cells in the pancreas, so the body can't convert the ...
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https://www.wnep.com/article/news/local/susquehanna-county/diabetes-study-could-hold-cure-to-disease-type-1/523-fae59b59-7e4e-4dba-a7d7-6537086a9a3e
Doctors say Type 1 Diabetes often develops in childhood. The disease destroys insulin cells in the pancreas, so the body can't convert the ...
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74
4.5: Looking Closely at Diabetes - Medicine LibreTexts
https://med.libretexts.org/Bookshelves/Nutrition/Book%3A_An_Introduction_to_Nutrition_(Zimmerman)/04%3A_Carbohydrates/4.05%3A_Looking_Closely_at_Diabetes
Diabetes is a disease of insulin deficiency and glucose oversufficiency. Like other diseases, genetics, nutrition, environment, ...
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https://med.libretexts.org/Bookshelves/Nutrition/Book%3A_An_Introduction_to_Nutrition_(Zimmerman)/04%3A_Carbohydrates/4.05%3A_Looking_Closely_at_Diabetes
Diabetes is a disease of insulin deficiency and glucose oversufficiency. Like other diseases, genetics, nutrition, environment, ...
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75
Potential new diabetes treatment gets tryout in Vancouver
https://www.med.ubc.ca/news/potential-new-diabetes-treatment-gets-tryout-in-vancouver/
The University of British Columbia and Vancouver Coastal Health are testing a possible diabetes cure that replaces a person's damaged ...
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https://www.med.ubc.ca/news/potential-new-diabetes-treatment-gets-tryout-in-vancouver/
The University of British Columbia and Vancouver Coastal Health are testing a possible diabetes cure that replaces a person's damaged ...
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