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Google Keyword Rankings for : pyruvate kinase diabetes
1
Pyruvate kinase M2 activation may protect against the ... - Nature
https://www.nature.com/articles/nm.4328
In conclusion, these findings suggest that PKM2 is a novel therapeutic target identified in glomeruli isolated from individuals with diabetes, ...
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https://www.nature.com/articles/nm.4328
In conclusion, these findings suggest that PKM2 is a novel therapeutic target identified in glomeruli isolated from individuals with diabetes, ...
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2
Characterization of Glycolytic Enzymes and Pyruvate Kinase ...
https://diabetesjournals.org/care/article/42/7/1263/36231/Characterization-of-Glycolytic-Enzymes-and
Insulin binding varied significantly depending upon the RBC population tested and was closely correlated to the activity of pyruvate kinase (r2 = 0.86), a well- ...
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https://diabetesjournals.org/care/article/42/7/1263/36231/Characterization-of-Glycolytic-Enzymes-and
Insulin binding varied significantly depending upon the RBC population tested and was closely correlated to the activity of pyruvate kinase (r2 = 0.86), a well- ...
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3
Regeneration of glomerular metabolism and function by ...
https://insight.jci.org/articles/view/155260
Pyruvate kinase (PK) activity in the glomeruli of PPKM2Tg mice was elevated by 35% (Figure 1E), indicating that the increase of PK activity was ...
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https://insight.jci.org/articles/view/155260
Pyruvate kinase (PK) activity in the glomeruli of PPKM2Tg mice was elevated by 35% (Figure 1E), indicating that the increase of PK activity was ...
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4
The Role of Pyruvate Kinase Regulation in Diabetic Retinopathy
https://iovs.arvojournals.org/article.aspx?articleid=2742713
PKM2 activation has recently been shown to protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. In this study, we ...
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https://iovs.arvojournals.org/article.aspx?articleid=2742713
PKM2 activation has recently been shown to protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. In this study, we ...
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5
Article Pyruvate Kinase Controls Signal Strength in the Insulin ...
https://www.sciencedirect.com/science/article/pii/S1550413120305404
Pancreatic β cells couple nutrient metabolism with appropriate insulin secretion. Here, we show that pyruvate kinase (PK), which converts ADP ...
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https://www.sciencedirect.com/science/article/pii/S1550413120305404
Pancreatic β cells couple nutrient metabolism with appropriate insulin secretion. Here, we show that pyruvate kinase (PK), which converts ADP ...
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6
Metabolic Functions of Pyruvate Kinase M2 in Pancreatic Beta ...
https://professional.diabetes.org/rdb/metabolic-functions-pyruvate-kinase-m2-pancreatic-beta-cells
By understanding how pyruvate kinase M2 regulates insulin secretion, we hope to develop drugs that would increase insulin secretion and prevent type 2 diabetes.
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https://professional.diabetes.org/rdb/metabolic-functions-pyruvate-kinase-m2-pancreatic-beta-cells
By understanding how pyruvate kinase M2 regulates insulin secretion, we hope to develop drugs that would increase insulin secretion and prevent type 2 diabetes.
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7
Pyruvate kinase isoenzyme M2 shows increased expression ...
https://www.easd.org/virtualmeeting/home.html#!resources/pyruvate-kinase-isoenzyme-m2-shows-increased-expression-in-diabetes
Pyruvate kinase isoenzyme M2 shows increased expression in diabetes. Abstract # 1314. Session: PS 119 Metabolism and complications. Vienna 2014. Poster Hall.
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https://www.easd.org/virtualmeeting/home.html#!resources/pyruvate-kinase-isoenzyme-m2-shows-increased-expression-in-diabetes
Pyruvate kinase isoenzyme M2 shows increased expression in diabetes. Abstract # 1314. Session: PS 119 Metabolism and complications. Vienna 2014. Poster Hall.
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8
The pivotal role of pyruvate dehydrogenase kinases in ...
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-11-10
Under diabetic conditions, expression of the PDK genes, particularly PDK4, are significantly elevated in the liver, which could help explain the ...
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https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-11-10
Under diabetic conditions, expression of the PDK genes, particularly PDK4, are significantly elevated in the liver, which could help explain the ...
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9
Pyruvate kinase blood test Information | Mount Sinai - New York
https://www.mountsinai.org/health-library/tests/pyruvate-kinase-blood-test
› health-library › tests › py...
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https://www.mountsinai.org/health-library/tests/pyruvate-kinase-blood-test
› health-library › tests › py...
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10
Starvation and diabetes increase the amount of pyruvate ...
https://portlandpress.com/biochemj/article/329/1/197/33533/Starvation-and-diabetes-increase-the-amount-of
Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart · Split-Screen · Views Icon Views. Article ...
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https://portlandpress.com/biochemj/article/329/1/197/33533/Starvation-and-diabetes-increase-the-amount-of
Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart · Split-Screen · Views Icon Views. Article ...
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11
β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate ...
https://elifesciences.org/articles/79422
Local ATP production by the plasma membrane-associated glycolytic enzyme pyruvate kinase is essential for the nutrient-dependent closure of ...
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https://elifesciences.org/articles/79422
Local ATP production by the plasma membrane-associated glycolytic enzyme pyruvate kinase is essential for the nutrient-dependent closure of ...
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12
Pyruvate kinase - Wikipedia
https://en.wikipedia.org/wiki/Pyruvate_kinase
Pyruvate kinase is the enzyme involved in the last step of glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ...
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https://en.wikipedia.org/wiki/Pyruvate_kinase
Pyruvate kinase is the enzyme involved in the last step of glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ...
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13
Pyruvate kinase M2 levels and activation as protective factors ...
https://grantome.com/grant/NIH/DP3-DK112192-01
Therefore, activating the key regulatory allosteric glycolytic enzyme, pyruvate kinase (PK), especially the M2 isoform, may increase flux via glycolysis and the ...
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https://grantome.com/grant/NIH/DP3-DK112192-01
Therefore, activating the key regulatory allosteric glycolytic enzyme, pyruvate kinase (PK), especially the M2 isoform, may increase flux via glycolysis and the ...
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14
Hypermethylation of Hepatic Glucokinase and L-Type ...
https://academic.oup.com/endo/article/152/4/1284/2457588
Obesity-dependent insulin resistance and type 2 diabetes mellitus are closely ... Hypermethylation of Hepatic Glucokinase and L-Type Pyruvate Kinase ...
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https://academic.oup.com/endo/article/152/4/1284/2457588
Obesity-dependent insulin resistance and type 2 diabetes mellitus are closely ... Hypermethylation of Hepatic Glucokinase and L-Type Pyruvate Kinase ...
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15
Insulin regulation of pyruvate kinase activity in isolated ...
https://www.jbc.org/article/S0021-9258(19)50150-8/pdf
pyruvate kinase represents another enzyme regulated ... RR05-5423 and a Research Grant from the American Diabetes As- sociation.
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https://www.jbc.org/article/S0021-9258(19)50150-8/pdf
pyruvate kinase represents another enzyme regulated ... RR05-5423 and a Research Grant from the American Diabetes As- sociation.
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16
Genetic Inactivation of Pyruvate Dehydrogenase Kinases ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071997
Under diabetic conditions, the Pdk genes, particularly Pdk4, are often induced, and the elevation of the Pdk4 gene expression has been ...
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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071997
Under diabetic conditions, the Pdk genes, particularly Pdk4, are often induced, and the elevation of the Pdk4 gene expression has been ...
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17
The role of PKM2 in diabetic microangiopathy | DMSO
https://www.dovepress.com/the-role-of-pkm2-in-diabetic-microangiopathy-peer-reviewed-fulltext-article-DMSO
As a glycolytic rate-limiting enzyme, pyruvate kinase can increase aerobic glycolysis rates by catalyzing phosphoenolpyruvate (PEP) conversion ...
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https://www.dovepress.com/the-role-of-pkm2-in-diabetic-microangiopathy-peer-reviewed-fulltext-article-DMSO
As a glycolytic rate-limiting enzyme, pyruvate kinase can increase aerobic glycolysis rates by catalyzing phosphoenolpyruvate (PEP) conversion ...
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18
Pyruvate kinase isoenzyme M2 is increased in experimental ...
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0035-1549780
Pyruvate kinase isoenzyme M2 is increased in experimental diabetes and correlates with diabetic neuropathy in patients ... Introduction: Pyruvate kinase (PK) ...
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https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0035-1549780
Pyruvate kinase isoenzyme M2 is increased in experimental diabetes and correlates with diabetic neuropathy in patients ... Introduction: Pyruvate kinase (PK) ...
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19
Pyruvate dehydrogenase kinase regulatory mechanisms and ...
https://link.springer.com/article/10.1007/s00018-007-6380-z
Activation of PDC by synthetic PDK inhibitors binding at the pyruvate or lipoyl binding sites decreased damage during heart ischemia and lowered ...
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https://link.springer.com/article/10.1007/s00018-007-6380-z
Activation of PDC by synthetic PDK inhibitors binding at the pyruvate or lipoyl binding sites decreased damage during heart ischemia and lowered ...
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20
Changes in Phosphofructokinase and Pyruvate Kinase in Rat ...
https://www.karger.com/Article/Abstract/469455
Insulin administration to the diabetic animals restored the activity of the enzymes. The results indicate a regionally variable effect of ...
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https://www.karger.com/Article/Abstract/469455
Insulin administration to the diabetic animals restored the activity of the enzymes. The results indicate a regionally variable effect of ...
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21
[PDF] Pyruvate kinase M2 activation may protect against the ...
https://www.researchgate.net/publication/316447914_Pyruvate_kinase_M2_activation_may_protect_against_the_progression_of_diabetic_glomerular_pathology_and_mitochondrial_dysfunction
Pyruvate kinase M2 activation may protect against diabetic nephropathy by increasing glucose metabolic flux, inhibiting the production of toxic ...
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https://www.researchgate.net/publication/316447914_Pyruvate_kinase_M2_activation_may_protect_against_the_progression_of_diabetic_glomerular_pathology_and_mitochondrial_dysfunction
Pyruvate kinase M2 activation may protect against diabetic nephropathy by increasing glucose metabolic flux, inhibiting the production of toxic ...
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22
glycolysis
https://www.ttuhsc.edu/medicine/academic-affairs/documents/sakai-files/bct/7_Glycolysis_Ganapathy.pdf
product of glycolysis, and the pyruvate gets oxidized in mitochondria ... diabetes, cAMP levels go up in liver; this activates protein kinase A, which then ...
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https://www.ttuhsc.edu/medicine/academic-affairs/documents/sakai-files/bct/7_Glycolysis_Ganapathy.pdf
product of glycolysis, and the pyruvate gets oxidized in mitochondria ... diabetes, cAMP levels go up in liver; this activates protein kinase A, which then ...
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23
The Warburg Effect in Diabetic Kidney Disease
https://www.seminarsinnephrology.org/article/S0270-9295(18)30002-0/fulltext
reported that enhanced pyruvate kinase II (PKM2) activity may preserve mitochondrial function by increasing glucose flux through glycolysis in podocytes and ...
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https://www.seminarsinnephrology.org/article/S0270-9295(18)30002-0/fulltext
reported that enhanced pyruvate kinase II (PKM2) activity may preserve mitochondrial function by increasing glucose flux through glycolysis in podocytes and ...
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24
Regulation of Rat Liver L‐Type Pyruvate Kinase mRNA by ...
https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1432-1033.1982.tb07004.x
The effects have been studied of streptozotocin-induced diabetes and subsequent insulin administration or feeding of a high fructose diet on the amount of ...
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https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1432-1033.1982.tb07004.x
The effects have been studied of streptozotocin-induced diabetes and subsequent insulin administration or feeding of a high fructose diet on the amount of ...
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25
Pyruvate dehydrogenase kinase-4 deficiency lowers blood ...
https://journals.physiology.org/doi/full/10.1152/ajpendo.00536.2007
The effect of pyruvate dehydrogenase kinase-4 (PDK4) deficiency on glucose homeostasis was studied in mice fed a high-fat diet.
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https://journals.physiology.org/doi/full/10.1152/ajpendo.00536.2007
The effect of pyruvate dehydrogenase kinase-4 (PDK4) deficiency on glucose homeostasis was studied in mice fed a high-fat diet.
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26
Pyruvate kinase, muscle isoform 2 promotes proliferation and ...
https://e-century.us/files/ijcep/8/11/ijcep0016565.pdf
Abstract: Failure of pancreatic β-cells is closely associated with type 2 diabetes mellitus (T2DM), an intractable disease affecting numerous patients.
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https://e-century.us/files/ijcep/8/11/ijcep0016565.pdf
Abstract: Failure of pancreatic β-cells is closely associated with type 2 diabetes mellitus (T2DM), an intractable disease affecting numerous patients.
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27
Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint ...
https://www.frontiersin.org/articles/10.3389/fimmu.2019.00944/full
In contrast, among the four PDK isozymes, PDK2 and PDK4 are the most strongly associated with metabolic diseases, especially type 2-diabetes (10) ...
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https://www.frontiersin.org/articles/10.3389/fimmu.2019.00944/full
In contrast, among the four PDK isozymes, PDK2 and PDK4 are the most strongly associated with metabolic diseases, especially type 2-diabetes (10) ...
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28
Pyruvate Dehydrogenase Kinases: Therapeutic Targets for ...
https://europepmc.org/articles/PMC4483603/
Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases including obesity, type 2 diabetes, and cancers.
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https://europepmc.org/articles/PMC4483603/
Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases including obesity, type 2 diabetes, and cancers.
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29
Management of pyruvate kinase deficiency in children and ...
https://ashpublications.org/blood/article/136/11/1241/461550/Management-of-pyruvate-kinase-deficiency-in
Pyruvate kinase deficiency (PKD) is an autosomal-recessive enzyme defect of the glycolytic pathway that causes congenital nonspherocytic ...
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https://ashpublications.org/blood/article/136/11/1241/461550/Management-of-pyruvate-kinase-deficiency-in
Pyruvate kinase deficiency (PKD) is an autosomal-recessive enzyme defect of the glycolytic pathway that causes congenital nonspherocytic ...
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30
In vivo effect of Trigonella foenum graecum on the expression ...
https://cdnsciencepub.com/doi/10.1139/y05-164
Liver pyruvate kinase (PK) and phosphoenolpyruvate carboxykinase (PEPCK), 2 key enzymes of glycolysis and gluconeogenesis, respectively, play a crucial role ...
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https://cdnsciencepub.com/doi/10.1139/y05-164
Liver pyruvate kinase (PK) and phosphoenolpyruvate carboxykinase (PEPCK), 2 key enzymes of glycolysis and gluconeogenesis, respectively, play a crucial role ...
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31
Pyruvate kinase M2 activation may protect against ... - BruKnow
https://bruknow.library.brown.edu/discovery/fulldisplay?docid=cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5575773&context=PC&vid=01BU_INST:BROWN&lang=en&search_scope=MyInst_and_CI&adaptor=Primo%20Central&tab=Everything&query=sub%2Cexact%2C%20Nitric%20Oxide%20Synthase%20Type%20III%20-%20genetics%20%2CAND&mode=advanced
Mechanistically, we showed that hyperglycemia and diabetes decreased PKM2 tetramer formation and activity by sulfenylation in mouse glomeruli and cultured ...
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https://bruknow.library.brown.edu/discovery/fulldisplay?docid=cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5575773&context=PC&vid=01BU_INST:BROWN&lang=en&search_scope=MyInst_and_CI&adaptor=Primo%20Central&tab=Everything&query=sub%2Cexact%2C%20Nitric%20Oxide%20Synthase%20Type%20III%20-%20genetics%20%2CAND&mode=advanced
Mechanistically, we showed that hyperglycemia and diabetes decreased PKM2 tetramer formation and activity by sulfenylation in mouse glomeruli and cultured ...
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32
Effects of bovine enterovirus and type 1 diabetes on ... - Redalyc
https://www.redalyc.org/journal/1871/187160125023/html/
Figure 2. Effect of streptozotocin-induced diabetes and bovine enterovirus on kidney pyruvate kinase activity in Wistar rats. Results are expressed as nmol of ...
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https://www.redalyc.org/journal/1871/187160125023/html/
Figure 2. Effect of streptozotocin-induced diabetes and bovine enterovirus on kidney pyruvate kinase activity in Wistar rats. Results are expressed as nmol of ...
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33
Aminoguanidine partially prevents the reduction in liver ...
https://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=260;epage=260;aulast=Majd
This modification changes the function of the proteins. The present study aimed to survey the effect of diabetes on rat liver pyruvate kinase ...
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https://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=260;epage=260;aulast=Majd
This modification changes the function of the proteins. The present study aimed to survey the effect of diabetes on rat liver pyruvate kinase ...
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34
Insulin Regulates Glucose Consumption and Lactate ...
https://www.hindawi.com/journals/omcl/2014/504953/
We found that insulin increased pyruvate kinase M2 (PKM2) expression through reactive oxygen species (ROS) for regulating glucose consumption and lactate ...
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https://www.hindawi.com/journals/omcl/2014/504953/
We found that insulin increased pyruvate kinase M2 (PKM2) expression through reactive oxygen species (ROS) for regulating glucose consumption and lactate ...
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35
17468529(pyruvate kinase)
https://bioinformatics.cs.vt.edu/connectingthedots/STORIES_CS3_SIG_FILT_HTML/17468529_17546295.html
In kidney medulla of rabbits with alloxan diabetes the pyruvate kinase activity was increased by 39 % as compared with control animals.
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https://bioinformatics.cs.vt.edu/connectingthedots/STORIES_CS3_SIG_FILT_HTML/17468529_17546295.html
In kidney medulla of rabbits with alloxan diabetes the pyruvate kinase activity was increased by 39 % as compared with control animals.
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36
Joshua Krämer Dr. med. Pyruvate Kinase Expression and ...
https://archiv.ub.uni-heidelberg.de/volltextserver/22750/1/Kr%C3%A4mer%2C%20Joshua.pdf
Pyruvate Kinase Expression and Activity in Hearts, Kidneys and Livers of Mice with. Streptozotocin-Induced Diabetes. Fach/Einrichtung: Innere Medizin.
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https://archiv.ub.uni-heidelberg.de/volltextserver/22750/1/Kr%C3%A4mer%2C%20Joshua.pdf
Pyruvate Kinase Expression and Activity in Hearts, Kidneys and Livers of Mice with. Streptozotocin-Induced Diabetes. Fach/Einrichtung: Innere Medizin.
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37
Health & Environmental Research Online (HERO) | US EPA
https://hero.epa.gov/hero/index.cfm/reference/details/reference_id/3697651
... on transcriptional regulation of pyruvate kinase, phosphoenolpyruvate carboxykinase, and GLUT4 translocation in experimental diabetic rats. Author(s).
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https://hero.epa.gov/hero/index.cfm/reference/details/reference_id/3697651
... on transcriptional regulation of pyruvate kinase, phosphoenolpyruvate carboxykinase, and GLUT4 translocation in experimental diabetic rats. Author(s).
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38
Aminoguanidine partially prevents the reduction in liver ...
https://agris.fao.org/agris-search/search.do?recordID=DJ20210501878
Aminoguanidine partially prevents the reduction in liver pyruvate kinase activity in diabetic rats [2014]. Alimohammad Amiri Majd; Mohammad Taghi Goodarzi; ...
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https://agris.fao.org/agris-search/search.do?recordID=DJ20210501878
Aminoguanidine partially prevents the reduction in liver pyruvate kinase activity in diabetic rats [2014]. Alimohammad Amiri Majd; Mohammad Taghi Goodarzi; ...
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39
Liver pyruvate kinase polymorphisms are ... - ProQuest
https://search.proquest.com/openview/f587a742673d3e56df09c7c732457f59/1?pq-origsite=gscholar&cbl=34443
Pyruvate kinase is a key glycolytic enzyme. Isoforms that are expressed in the red cell, liver, pancreatic beta-cells, small intestine, and proximal renal ...
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https://search.proquest.com/openview/f587a742673d3e56df09c7c732457f59/1?pq-origsite=gscholar&cbl=34443
Pyruvate kinase is a key glycolytic enzyme. Isoforms that are expressed in the red cell, liver, pancreatic beta-cells, small intestine, and proximal renal ...
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40
Cardiac Insulin Signaling Regulates Glycolysis Through ...
https://www.ahajournals.org/doi/10.1161/JAHA.117.007159
Diabetes mellitus disrupts this metabolic flexibility and promotes ... In contrast, pyruvate dehydrogenase kinase 4, a protein known to be ...
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https://www.ahajournals.org/doi/10.1161/JAHA.117.007159
Diabetes mellitus disrupts this metabolic flexibility and promotes ... In contrast, pyruvate dehydrogenase kinase 4, a protein known to be ...
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41
Role of M2 isoform of pyruvate kinase in diabetic retinopathy
https://pesquisa.bvsalud.org/portal/resource/pt/wpr-913032
Pyruvate kinase(PK)M2(M2 isoform of pyruvate kinase)is a key enzyme of glycolysis and is widely expressed in most tissues. As major cellular components in the ...
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https://pesquisa.bvsalud.org/portal/resource/pt/wpr-913032
Pyruvate kinase(PK)M2(M2 isoform of pyruvate kinase)is a key enzyme of glycolysis and is widely expressed in most tissues. As major cellular components in the ...
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42
Molecule of the Month: Pyruvate Kinase M2 - PDB-101
https://pdb101.rcsb.org/motm/270
Pyruvate kinases are the paradoxical gatekeepers for cancer cell metabolism and growth. This article was written and illustrated by Faiza Ahmed, Jonathan Ash, ...
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https://pdb101.rcsb.org/motm/270
Pyruvate kinases are the paradoxical gatekeepers for cancer cell metabolism and growth. This article was written and illustrated by Faiza Ahmed, Jonathan Ash, ...
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43
New Discoveries About Glucose Metabolism Could Improve ...
https://medicine.yale.edu/news-article/new-discoveries-about-glucose-metabolism-could-improve-diabetes-treatment/
The research suggests that in addition to improving insulin secretion, a potential therapeutic approach that activates pyruvate kinase also ...
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https://medicine.yale.edu/news-article/new-discoveries-about-glucose-metabolism-could-improve-diabetes-treatment/
The research suggests that in addition to improving insulin secretion, a potential therapeutic approach that activates pyruvate kinase also ...
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44
Pyruvate kinase M2 activation may protect against the ... - CiteAb
https://www.citeab.com/publication/2584025-28436957-pyruvate-kinase-m2-activation-may-protect-against-t
Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Abstract.
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https://www.citeab.com/publication/2584025-28436957-pyruvate-kinase-m2-activation-may-protect-against-t
Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Abstract.
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45
How we manage patients with pyruvate kinase deficiency
https://www.thalassaemia.org.cy/wp-content/uploads/2020/10/2019_How-we-manage-patients-with-pyruvate-kinase-deficiency.pdf
dysfunction, sex hormone abnormalities and diabetes. Note that a haemoglobin A1C will not be accurate in the setting of haemolytic anaemia; ...
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https://www.thalassaemia.org.cy/wp-content/uploads/2020/10/2019_How-we-manage-patients-with-pyruvate-kinase-deficiency.pdf
dysfunction, sex hormone abnormalities and diabetes. Note that a haemoglobin A1C will not be accurate in the setting of haemolytic anaemia; ...
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46
Effects of bovine enterovirus and type 1 diabetes on liver and ...
https://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43765
Effects of bovine enterovirus and type 1 diabetes on liver and kidney pyruvate kinase activity in an animal model.
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https://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43765
Effects of bovine enterovirus and type 1 diabetes on liver and kidney pyruvate kinase activity in an animal model.
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47
Diabetes and PKM2 affect prognosis in patients with ...
https://www.spandidos-publications.com/10.3892/ol.2020.12128
Diabetes mellitus (DM) is a common disease, but its effect on the ... with hepatectomy and to clarify the role of pyruvate kinase M2 (PKM2).
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https://www.spandidos-publications.com/10.3892/ol.2020.12128
Diabetes mellitus (DM) is a common disease, but its effect on the ... with hepatectomy and to clarify the role of pyruvate kinase M2 (PKM2).
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48
Liver pyruvate kinase polymorphisms are associated ... - Gale
https://go.gale.com/ps/i.do?id=GALE%7CA91202452&sid=googleScholar&v=2.1&it=r&linkaccess=fulltext&issn=00121797&p=AONE&sw=w
Genome-wide scans from a number of laboratories suggest that multiple genes are likely to contribute to diabetes susceptibility. A type 2 diabetes locus on ...
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https://go.gale.com/ps/i.do?id=GALE%7CA91202452&sid=googleScholar&v=2.1&it=r&linkaccess=fulltext&issn=00121797&p=AONE&sw=w
Genome-wide scans from a number of laboratories suggest that multiple genes are likely to contribute to diabetes susceptibility. A type 2 diabetes locus on ...
→ Check Latest Keyword Rankings ←
49
The Role of Pyruvate Dehydrogenase Kinase in Diabetes and ...
https://www.semanticscholar.org/paper/The-Role-of-Pyruvate-Dehydrogenase-Kinase-in-and-Lee/9f1150b9d2bc566b5a73da98d639178cd5940fda
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome and is a key intermediate of glucose ...
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https://www.semanticscholar.org/paper/The-Role-of-Pyruvate-Dehydrogenase-Kinase-in-and-Lee/9f1150b9d2bc566b5a73da98d639178cd5940fda
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome and is a key intermediate of glucose ...
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50
Role of the Pyruvate Dehydrogenase Complex in Metabolic ...
https://synapse.koreamed.org/articles/1142299
PDK isoforms are increased in metabolic diseases including obesity, diabetes, heart failure, and cancer, and upregulated PDK2 is a potential ...
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https://synapse.koreamed.org/articles/1142299
PDK isoforms are increased in metabolic diseases including obesity, diabetes, heart failure, and cancer, and upregulated PDK2 is a potential ...
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51
Insulinotropic effect of cinnamaldehyde on transcriptional ...
https://www.academia.edu/5870574/Insulinotropic_effect_of_cinnamaldehyde_on_transcriptional_regulation_of_pyruvate_kinase_phosphoenolpyruvate_carboxykinase_and_GLUT4_translocation_in_experimental_diabetic_rats
... on transcriptional regulation of pyruvate kinase, phosphoenolpyruvate carboxykinase, and GLUT4 translocation in experimental diabetic rats.
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https://www.academia.edu/5870574/Insulinotropic_effect_of_cinnamaldehyde_on_transcriptional_regulation_of_pyruvate_kinase_phosphoenolpyruvate_carboxykinase_and_GLUT4_translocation_in_experimental_diabetic_rats
... on transcriptional regulation of pyruvate kinase, phosphoenolpyruvate carboxykinase, and GLUT4 translocation in experimental diabetic rats.
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52
Pyruvate Kinase Inactive When Blood Sugar Is High - ANGONO
https://angono.gov.ph/blood-sugar/pyruvate-kinase-inactive-when-blood-sugar-is-high
... sugar between meals Some might help with weight loss or cholesterol, in Pyruvate Kinase Inactive When Blood Sugar Is High addition to your diabetes.
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https://angono.gov.ph/blood-sugar/pyruvate-kinase-inactive-when-blood-sugar-is-high
... sugar between meals Some might help with weight loss or cholesterol, in Pyruvate Kinase Inactive When Blood Sugar Is High addition to your diabetes.
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53
Showing Protein Pyruvate kinase isozymes R/L (HMDBP00765)
https://hmdb.ca/proteins/HMDBP00765
Pyruvate kinase 1; R-type/L-type pyruvate kinase; Red cell/liver pyruvate kinase ... Maturity onset diabetes of the young; Primary hyperoxaluria II, PH2 ...
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https://hmdb.ca/proteins/HMDBP00765
Pyruvate kinase 1; R-type/L-type pyruvate kinase; Red cell/liver pyruvate kinase ... Maturity onset diabetes of the young; Primary hyperoxaluria II, PH2 ...
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54
Pyruvate Kinase Deficiency - Medscape Reference
https://emedicine.medscape.com/article/2196589-overview
Pyruvate kinase deficiency is one of the most common enzymatic defects of the erythrocyte. This disorder manifests clinically as a hemolytic ...
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https://emedicine.medscape.com/article/2196589-overview
Pyruvate kinase deficiency is one of the most common enzymatic defects of the erythrocyte. This disorder manifests clinically as a hemolytic ...
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55
Pyruvate Kinase Inactive When Blood Sugar Is High - Mary Kay
https://marykay.sv/type-2-diabetes/pyruvate-kinase-CmQ-inactive-when-blood-sugar-is-high/
you may have prediabetes or diabetes contact a health pyruvate kinase inactive when blood sugar is high care professional. In rare circumstances of uncontrolled ...
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https://marykay.sv/type-2-diabetes/pyruvate-kinase-CmQ-inactive-when-blood-sugar-is-high/
you may have prediabetes or diabetes contact a health pyruvate kinase inactive when blood sugar is high care professional. In rare circumstances of uncontrolled ...
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56
Long-running Joslin study leads to potential therapeutic target ...
https://www.joslin.org/about/news-media/long-running-joslin-study-leads-potential-therapeutic-target-people-type-1
Persistent hyperglycemia puts people with diabetes at increased risk for ... such as pyruvate kinase M2 (PKM2) – may play a protective role, ...
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https://www.joslin.org/about/news-media/long-running-joslin-study-leads-potential-therapeutic-target-people-type-1
Persistent hyperglycemia puts people with diabetes at increased risk for ... such as pyruvate kinase M2 (PKM2) – may play a protective role, ...
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57
SUN-308 PYRUVATE KINASE MUSCLE TYPE 2 (PKM2) AS A ...
https://www.kireports.org/article/S2468-0249(19)30910-6/pdf
PYRUVATE KINASE MUSCLE TYPE 2 (PKM2) AS. A URINARY BIOMARKER OF DIABETIC KIDNEY. DISEASE. TOSHIYUKI, I*1, Kawaguchi, T1, Hiroshi, K2, Motonobu, N1.
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https://www.kireports.org/article/S2468-0249(19)30910-6/pdf
PYRUVATE KINASE MUSCLE TYPE 2 (PKM2) AS. A URINARY BIOMARKER OF DIABETIC KIDNEY. DISEASE. TOSHIYUKI, I*1, Kawaguchi, T1, Hiroshi, K2, Motonobu, N1.
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58
Pyruvate kinase M2 regulates adipocyte differentiation and the ...
https://aacrjournals.org/cancerpreventionresearch/article/8/10_Supplement/B36/31031/Abstract-B36-Pyruvate-kinase-M2-regulates
Pyruvate kinase (PK) mediates the rate-limiting step of glycolysis. The M2 isoform of PK (PKM2) is expressed in adipocytes but its role in ...
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https://aacrjournals.org/cancerpreventionresearch/article/8/10_Supplement/B36/31031/Abstract-B36-Pyruvate-kinase-M2-regulates
Pyruvate kinase (PK) mediates the rate-limiting step of glycolysis. The M2 isoform of PK (PKM2) is expressed in adipocytes but its role in ...
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59
New study gives hope to those with Type 2 diabetes - The Week
https://www.theweek.in/news/health/2020/11/15/new-study-gives-hope-to-those-with-type-2-diabetes.html
The findings suggest that activating pyruvate kinase could be a new way to increase insulin secretion to counter Type 2 diabetes, ...
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https://www.theweek.in/news/health/2020/11/15/new-study-gives-hope-to-those-with-type-2-diabetes.html
The findings suggest that activating pyruvate kinase could be a new way to increase insulin secretion to counter Type 2 diabetes, ...
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60
Effect of water and saline overload on the pyruvate kinase and ...
https://journals.indexcopernicus.com/api/file/viewByFileId/550704.pdf
Keywords: water and saline overload, pyruvate kinase, glucose-6-phosphatase, liver, diabetic rats. Introduction. Type 1 Diabetes Mellitus (T1DM) is a.
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https://journals.indexcopernicus.com/api/file/viewByFileId/550704.pdf
Keywords: water and saline overload, pyruvate kinase, glucose-6-phosphatase, liver, diabetic rats. Introduction. Type 1 Diabetes Mellitus (T1DM) is a.
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61
Anti-diabetic effect of the polyphenol-rich extract from ...
https://www.ajol.info/index.php/tjpr/article/view/195841
HC treatment markedly elevated liver glycogen content and activity of hepatic glucokinase and pyruvate kinase (p < 0.05).
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https://www.ajol.info/index.php/tjpr/article/view/195841
HC treatment markedly elevated liver glycogen content and activity of hepatic glucokinase and pyruvate kinase (p < 0.05).
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62
Glycolytic enzyme expression and pyruvate kinase activity in ...
https://www.madforcancer.lu.se/peter-james/publication/f6778439-3a7c-4ef9-9d14-059a81494012
Since type 1 diabetes mellitus (T1DM) patients with nephropathy (DN+) are insulin-resistant, we aimed to identify (new) potential molecular sites involved in ...
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https://www.madforcancer.lu.se/peter-james/publication/f6778439-3a7c-4ef9-9d14-059a81494012
Since type 1 diabetes mellitus (T1DM) patients with nephropathy (DN+) are insulin-resistant, we aimed to identify (new) potential molecular sites involved in ...
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63
Rapid Regulation of L-Type Pyruvate Kinase mRNA ... - J-Stage
https://www.jstage.jst.go.jp/article/biochemistry1922/96/5/96_5_1457/_pdf
The effect of fructose on the induction of L-type pyruvate kinase mRNA in diabetic rat liver was studied by using a cloned cDNA probe.
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https://www.jstage.jst.go.jp/article/biochemistry1922/96/5/96_5_1457/_pdf
The effect of fructose on the induction of L-type pyruvate kinase mRNA in diabetic rat liver was studied by using a cloned cDNA probe.
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64
Pyruvate Kinase Deficiency - NORD (National Organization for ...
https://rarediseases.org/rare-diseases/pyruvate-kinase-deficiency/
Pyruvate kinase is an enzyme that helps cells turn sugar (glucose) into energy (called adenosine triphosphate, ATP) in a process called glycolysis. Red cells ...
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https://rarediseases.org/rare-diseases/pyruvate-kinase-deficiency/
Pyruvate kinase is an enzyme that helps cells turn sugar (glucose) into energy (called adenosine triphosphate, ATP) in a process called glycolysis. Red cells ...
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65
Insulin & Role of Liver - Blood Glucose Regulation Part 2
https://www.youtube.com/watch?v=OF0UPWIVQC8
Dr. Najeeb Lectures
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https://www.youtube.com/watch?v=OF0UPWIVQC8
Dr. Najeeb Lectures
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66
Best Type 2 Diabetes Medication High Sugar Medicine
https://moviebill.com/high-sugar-medicine-m4zJszx.html
Symptoms including the American Diabetes Association - type 2 diabetes current ... diabetes drug pyruvate dehydrogenase kinase and patients who are ...
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https://moviebill.com/high-sugar-medicine-m4zJszx.html
Symptoms including the American Diabetes Association - type 2 diabetes current ... diabetes drug pyruvate dehydrogenase kinase and patients who are ...
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67
Diabetes - Symptoms and causes - Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/diabetes/symptoms-causes/syc-20371444
Diabetes mellitus refers to a group of diseases that affect how the body uses blood sugar (glucose). Glucose is an important source of ...
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https://www.mayoclinic.org/diseases-conditions/diabetes/symptoms-causes/syc-20371444
Diabetes mellitus refers to a group of diseases that affect how the body uses blood sugar (glucose). Glucose is an important source of ...
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68
Pyruvate kinase deficiency: MedlinePlus Medical Encyclopedia
https://medlineplus.gov/ency/article/001197.htm
Pyruvate kinase deficiency is an inherited lack of the enzyme pyruvate kinase, which is used by red blood cells.
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https://medlineplus.gov/ency/article/001197.htm
Pyruvate kinase deficiency is an inherited lack of the enzyme pyruvate kinase, which is used by red blood cells.
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69
KEGG PATHWAY Database
https://www.genome.jp/kegg/pathway.html
... 00520 M N: Amino sugar and nucleotide sugar metabolism; 00620 M: Pyruvate metabolism ... 04933: AGE-RAGE signaling pathway in diabetic complications ...
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https://www.genome.jp/kegg/pathway.html
... 00520 M N: Amino sugar and nucleotide sugar metabolism; 00620 M: Pyruvate metabolism ... 04933: AGE-RAGE signaling pathway in diabetic complications ...
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70
長谷川一宏先生論文内容：糖尿病性腎症ーPKM2とWaruburg ...
https://keio-emn.jp/photo/20190208-2/
Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Nat Med.
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https://keio-emn.jp/photo/20190208-2/
Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Nat Med.
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71
DOACs in Review - How did we get here?
https://www.emjreviews.com/hematology/webinars/doacs-in-review-how-did-we-get-here/
Diabetes · Flagship Journal ... Diabetes · Flagship Journal ... Exploring a Role for Mitapivat in Children with Pyruvate Kinase Deficiency.
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https://www.emjreviews.com/hematology/webinars/doacs-in-review-how-did-we-get-here/
Diabetes · Flagship Journal ... Diabetes · Flagship Journal ... Exploring a Role for Mitapivat in Children with Pyruvate Kinase Deficiency.
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72
ACS Central Science | Vol 7, No 12
https://pubs.acs.org/toc/acscii/7/12
Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19. John A. McIntosh *; ,; Tamas Benkovics ...
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https://pubs.acs.org/toc/acscii/7/12
Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19. John A. McIntosh *; ,; Tamas Benkovics ...
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73
14 Signs of Iron Deficiency Anemia - Healthline
https://www.healthline.com/nutrition/iron-deficiency-signs-symptoms
... use of certain drugs, including chemotherapy, diabetes, and antimicrobial drugs, ... dehydrogenase (G6PD) deficiency and pyruvate kinase (PK) deficiency ...
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https://www.healthline.com/nutrition/iron-deficiency-signs-symptoms
... use of certain drugs, including chemotherapy, diabetes, and antimicrobial drugs, ... dehydrogenase (G6PD) deficiency and pyruvate kinase (PK) deficiency ...
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74
How Does 23andMe Work: DNA Test Instructions & Reporting
https://www.23andme.com/howitworks/
Type 2 Diabetes ( Powered by 23andMe Research ) ... Dihydrolipoamide Dehydrogenase Deficiency. 1 variant in the DLD gene; ... Pyruvate Kinase Deficiency.
→ Check Latest Keyword Rankings ←
https://www.23andme.com/howitworks/
Type 2 Diabetes ( Powered by 23andMe Research ) ... Dihydrolipoamide Dehydrogenase Deficiency. 1 variant in the DLD gene; ... Pyruvate Kinase Deficiency.
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75
Answered: 4. Consider the different types of SNPs… | bartleby
https://www.bartleby.com/questions-and-answers/4.-consider-the-different-types-of-snps-shown-in-figure-3-associated-unassociated-and-causative-incl/d1709a32-c1fa-45e6-9197-03623b8525e4
"We think this approach will help pinpoint multiple genes involved in complex human conditions, such as cancer, heart disease, diabetes and obesity." www.
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https://www.bartleby.com/questions-and-answers/4.-consider-the-different-types-of-snps-shown-in-figure-3-associated-unassociated-and-causative-incl/d1709a32-c1fa-45e6-9197-03623b8525e4
"We think this approach will help pinpoint multiple genes involved in complex human conditions, such as cancer, heart disease, diabetes and obesity." www.
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76
oxidation of ketone produces - Império – Soluções em EPS
https://imperiosolucoeseps.com.br/lyjx5/page.php?id=oxidation-of-ketone-produces
[1] It is theorized to play a role in explaining type 2 diabetes and insulin resistance. ... These both serve to inhibit pyruvate dehydrogenase activity.
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https://imperiosolucoeseps.com.br/lyjx5/page.php?id=oxidation-of-ketone-produces
[1] It is theorized to play a role in explaining type 2 diabetes and insulin resistance. ... These both serve to inhibit pyruvate dehydrogenase activity.
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77
acylation of alcohol mechanism
http://www.aracnofa.com.br/ibpdeymm/acylation-of-alcohol-mechanism
Metabolism of PEP to pyruvic acid by pyruvate kinase (PK) generates adenosine ... Error bars represent s.d. CYP2D6, and several important diabetes drugs are ...
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http://www.aracnofa.com.br/ibpdeymm/acylation-of-alcohol-mechanism
Metabolism of PEP to pyruvic acid by pyruvate kinase (PK) generates adenosine ... Error bars represent s.d. CYP2D6, and several important diabetes drugs are ...
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78
Joslin's Diabetes Mellitus: Edited by C. Ronald Kahn ... [et ...
https://books.google.com/books?id=ohgjG0qAvfgC&pg=PA253&lpg=PA253&dq=pyruvate+kinase+diabetes&source=bl&ots=yLFs9CO6Ct&sig=ACfU3U39qGaCcyF1MCogtqcneHMKyG9LIw&hl=en&sa=X&ved=2ahUKEwjF7IHf59P7AhWknGoFHcG3COwQ6AF6BQi7AhAD
The other product of this cycle , F - 1,6 - P2 causes feedforward activation of pyruvate kinase , a key component of the downstream substrate cycle .
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https://books.google.com/books?id=ohgjG0qAvfgC&pg=PA253&lpg=PA253&dq=pyruvate+kinase+diabetes&source=bl&ots=yLFs9CO6Ct&sig=ACfU3U39qGaCcyF1MCogtqcneHMKyG9LIw&hl=en&sa=X&ved=2ahUKEwjF7IHf59P7AhWknGoFHcG3COwQ6AF6BQi7AhAD
The other product of this cycle , F - 1,6 - P2 causes feedforward activation of pyruvate kinase , a key component of the downstream substrate cycle .
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79
Cyclic Nucleotides: Part II: Physiology and Pharmacology
https://books.google.com/books?id=UV_wCAAAQBAJ&pg=PA32&lpg=PA32&dq=pyruvate+kinase+diabetes&source=bl&ots=6mX9coYmu9&sig=ACfU3U3HKGifQcXvFbAhGnXp93aWPk69dQ&hl=en&sa=X&ved=2ahUKEwjF7IHf59P7AhWknGoFHcG3COwQ6AF6BQi6AhAD
Thus, the known increases in P-enolpyruvate carboxykinase and glucose-6-phosphatase and decreases in glucokinase and pyruvate kinase in diabetes and ...
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https://books.google.com/books?id=UV_wCAAAQBAJ&pg=PA32&lpg=PA32&dq=pyruvate+kinase+diabetes&source=bl&ots=6mX9coYmu9&sig=ACfU3U3HKGifQcXvFbAhGnXp93aWPk69dQ&hl=en&sa=X&ved=2ahUKEwjF7IHf59P7AhWknGoFHcG3COwQ6AF6BQi6AhAD
Thus, the known increases in P-enolpyruvate carboxykinase and glucose-6-phosphatase and decreases in glucokinase and pyruvate kinase in diabetes and ...
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80
Diabetes Literature Index
https://books.google.com/books?id=fAcBP_gNJ4AC&pg=PA1850&lpg=PA1850&dq=pyruvate+kinase+diabetes&source=bl&ots=lei0nYD4mf&sig=ACfU3U2_wYigaax3jDulP1YaAv3gWNb_dA&hl=en&sa=X&ved=2ahUKEwjF7IHf59P7AhWknGoFHcG3COwQ6AF6BQi4AhAD
CONTROL OF PYRUVATE KINASE ACTIVITY BY GLUCAGON IN ISOLATED HEPATOCYTES . Riou JP , Claus TH , Pilkis SJ Biochem Biophys Res Commun 73 : 591-9 , 6 Dec 76 ...
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https://books.google.com/books?id=fAcBP_gNJ4AC&pg=PA1850&lpg=PA1850&dq=pyruvate+kinase+diabetes&source=bl&ots=lei0nYD4mf&sig=ACfU3U2_wYigaax3jDulP1YaAv3gWNb_dA&hl=en&sa=X&ved=2ahUKEwjF7IHf59P7AhWknGoFHcG3COwQ6AF6BQi4AhAD
CONTROL OF PYRUVATE KINASE ACTIVITY BY GLUCAGON IN ISOLATED HEPATOCYTES . Riou JP , Claus TH , Pilkis SJ Biochem Biophys Res Commun 73 : 591-9 , 6 Dec 76 ...
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81
Pyruvate Kinase - Biochemistry Flashcards - Draw It to Know It
https://www.drawittoknowit.com/course/biochemistry/glossary/biochemical-pathway/pyruvate-kinase
› biochemical-pathway
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https://www.drawittoknowit.com/course/biochemistry/glossary/biochemical-pathway/pyruvate-kinase
› biochemical-pathway
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82
Type 2 Diabetes: Symptoms, Causes, Diagnosis, Diet, and ...
https://www.everydayhealth.com/type-2-diabetes/guide/
Type 2 diabetes is a form of diabetes mellitus caused by insulin resistance that leads to high blood sugar. In this detailed overview, learn how to spot ...
→ Check Latest Keyword Rankings ←
https://www.everydayhealth.com/type-2-diabetes/guide/
Type 2 diabetes is a form of diabetes mellitus caused by insulin resistance that leads to high blood sugar. In this detailed overview, learn how to spot ...
→ Check Latest Keyword Rankings ←
83
What is Pyruvate Kinase Deficiency
https://pyruvatekinasedeficiency.com/mechanism-of-pkd/
As explained in the basics about blood, pyruvate kinase is an enzyme that plays an important role in the energy supply of the red blood cells. When there's a ...
→ Check Latest Keyword Rankings ←
https://pyruvatekinasedeficiency.com/mechanism-of-pkd/
As explained in the basics about blood, pyruvate kinase is an enzyme that plays an important role in the energy supply of the red blood cells. When there's a ...
→ Check Latest Keyword Rankings ←
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