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1 Herpesvirus DNA polymerases: Structures ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/28153606/
Human herpesviruses are large double-stranded DNA viruses belonging to the Herpesviridae family. These viruses have the ability to establish ...
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2 Structure and inhibition of herpesvirus DNA packaging ... - PNAS
https://www.pnas.org/doi/10.1073/pnas.1007144107
The HCMV genome consists of linear dsDNA of 230 kb with the highest coding capacity among Herpesviridae. HCMV, like all other herpesviruses, replicates its ...
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3 Herpes Simplex Viruses: Mechanisms of DNA Replication
https://cshperspectives.cshlp.org/content/4/9/a013011.full
HSV DNA synthesis is believed to initiate at one of the three viral origins of replication, OriL or one of the two copies of OriS with UL9 and ICP8 acting to ...
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4 Structural understanding of non-nucleoside inhibition in an ...
https://www.nature.com/articles/s41467-021-23312-8
Herpesvirus polymerases belong to the B-family DNA polymerases which include eukaryotic polymerases (α, δ, ε, ζ), amongst other archaeal, ...
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5 Crystal Structure of the Gamma-2 Herpesvirus LANA DNA ...
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003673
The structure reveals an alpha-beta fold that assembles as a dimer, reminiscent of Epstein-Barr virus EBNA1. A predicted DNA binding surface is ...
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6 Herpesviruses and Chromosomal Integration - ASM Journals
https://journals.asm.org/doi/10.1128/JVI.01169-10
The genomic structure of MDV is analogous to that of herpes simplex virus, consisting of a long unique sequence (UL) and a short unique sequence ...
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7 Herpes simplex-1 genome organization - ViralZone
https://viralzone.expasy.org/5756
The genome of HHV-1 is linear, double stranded DNA composed of 152,000 base pairs. It contains two unique regions (UL and US), each flanked by inverted repeats ...
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8 Ancient herpes simplex 1 genomes reveal recent viral ...
https://www.science.org/doi/10.1126/sciadv.abo4435
HSV-1 DNA is detectable in blood during primary infection but not during reactivation from latency (26); however, herpesvirus DNA and ...
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9 HSV-1 DNA Replication—Coordinated Regulation by Viral ...
https://www.mdpi.com/1999-4915/13/10/2015
DNA replication is an integral step in the herpes simplex virus type 1 (HSV-1) life cycle that is coordinated with the cellular DNA damage response, ...
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10 Formation of DNA replication structures in herpes virus ...
https://www.cell.com/abstract/0092-8674(88)90141-9
We demonstrate here that cellular DNA replication sites identified by bromodeoxyuridine labeling are relocated in cells infected with herpes simplex virus such ...
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11 Herpes Virus Replication
https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1080/1521654031000070645
STRUCTURE OF THE VIRAL GENOME. The viral nucleocapsid contains a single copy of a linear duplex DNA. With a few exceptions, all herpesvirus genomes,.
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12 2GV9: Crystal structure of the Herpes Simplex virus type 1 ...
https://www.rcsb.org/structure/2gv9
Crystal structure of the Herpes Simplex virus type 1 DNA polymerase. ... Herpesviruses are the second leading cause of human viral diseases.
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13 Architecture of the herpesvirus genome-packaging complex ...
https://link.springer.com/article/10.1007/s13238-020-00710-0
The architecture of the hexameric terminase assembly reveals structural features necessary for sequential revolution DNA translocation and ...
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14 Herpesvirus overview
http://stdgen.northwestern.edu/stdgen/bacteria/hhv2/herpes.html
Herpesvirus genomes range in length from 120 to 230 kbp with base composition from 31% to 75% G+C content and contain 60 to 120 genes. Because replication takes ...
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15 The three-component helicase/primase complex of herpes ...
https://royalsocietypublishing.org/doi/10.1098/rsob.210011
Among these are the herpes virus DNA helicase and primase that are essential components of its replication machinery. In the HSV-1 replisome ...
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16 Distribution and effects of amino acid changes in drug ...
https://academic.oup.com/nar/article/44/20/9530/2608009
Herpesvirus DNA polymerase (DNApol) is currently the target of ... Structure of the most common nucleos(t)ide analogues used in antiherpesvirus therapy.
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17 Replication of Herpes Simplex Virus DNA*
https://www.jbc.org/article/S0021-9258(19)52015-4/pdf
Structure of the herpes simplex virus type 1 genome. A diagrammatic representation of the HSV-1 genome is shown. The positions of the a, b, and c repeats within ...
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18 Herpesvirus latency - JCI
https://www.jci.org/articles/view/136225
Herpesvirus latency requires the virus to establish a persistent infection in cells without destruction by the immune system. Viral DNA is ...
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19 packaging terminase nuclease domain - JSTOR
https://www.jstor.org/stable/20779619
Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain ... During viral replication, herpesviruses package their DNA into the.
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20 Herpes Virus Genome, The Pressure Is On - ACS Publications
https://pubs.acs.org/doi/10.1021/ja404008r
(1) Herpesviruses consist of a double-stranded DNA (dsDNA) molecule contained within a rigid protein shell, termed the capsid. HSV-1 is a ...
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21 Herpes simplex virus - Wikipedia
https://en.wikipedia.org/wiki/Herpes_simplex_virus
Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known by their taxonomical names Human alphaherpesvirus 1 and Human alphaherpesvirus 2, are two members of ...
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22 Insights into herpesvirus assembly from the structure of ... - eLife
https://elifesciences.org/articles/53789
Herpesviruses acquire their membrane envelopes in the cytoplasm of infected cells via a molecular mechanism that remains unclear.
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23 REPLICATION OF dsDNA GENOME VIRUSES A. Herpesviruses
https://www.lehigh.edu/~jas0/V04a.html
HSV-1 DNA replication occurs via a rolling circle process that produces concatemeric (i.e. multiple length) copies of the genome. This process is carried out by ...
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24 Replication Compartments of Eukaryotic and Bacterial DNA ...
https://www.annualreviews.org/doi/pdf/10.1146/annurev-virology-012822-125828
cells. 2. REPLICATION COMPARTMENTS IN EUKARYOTIC. NUCLEAR-REPLICATING DNA VIRUSES. 2.1. Herpes Simplex Virus. HSV undergoes a lytic, productive infection of ...
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25 Herpesvirus DNA Polymerases: Structures ... - ResearchGate
https://www.researchgate.net/publication/313112322_Herpesvirus_DNA_Polymerases_Structures_Functions_and_Inhibitors
... The Herpes virus polymerases range in size from 1012 to 1242 amino acids and display about 34-90% primary sequence identity. Herpes Simplex 1 DNA polymerase ...
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26 DNA polymerase catalytic subunit | UniProtKB - UniProt
https://www.uniprot.org/uniprot/P04293
The replication complex is composed of six viral proteins: the DNA polymerase, ... Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
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27 Herpesvirus DNA polymerases: Structures ... - Europe PMC
https://europepmc.org/article/med/28153606
Human herpesviruses are large double-stranded DNA viruses belonging to the Herpesviridae family. These viruses have the ability to establish lifelong ...
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28 [PDF] Crystal Structure of the Herpes Simplex Virus 1 DNA ...
https://www.semanticscholar.org/paper/Crystal-Structure-of-the-Herpes-Simplex-Virus-1-DNA-Liu-Knafels/56eb6721fcc424c207e9977bbe4f0e84391dc2dc
The first crystal structure of a herpesvirus polymerase is presented, the Herpes Simplex Virus type 1 DNA polymerase, at 2.7 Å resolution ...
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29 Herpesvirus Late Gene Expression: A Viral-Specific ... - Frontiers
https://www.frontiersin.org/articles/10.3389/fmicb.2016.00869/full
Following viral DNA replication, late (L or γ) viral genes – that mainly encode structural proteins – start to be transcribed, ultimately ...
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30 Assessing the contribution of the herpes simplex virus DNA ...
https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-2-7
Additionally, plasmid DNA containing the HSV-2 tk gene, but not type 1 ... and (b) the localized secondary structure of the viral genome may ...
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31 Scientists reveal DNA packaging mechanism of HSV-1, the ...
https://newsroom.ucla.edu/releases/dna-mechanism-hsv1-virus-cold-sores
For example, the researchers identified a portal cap structure that “corks” the viral genome in the high-pressurized capsid, along with ...
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32 Structure of Replicating Herpes Simplex Virus DNA
https://cdr.lib.unc.edu/downloads/r781wq05d
significance to possible models of herpes simplex virus DNA replication. Herpes simplex virus type 1 (HSV-1) has a linear double-stranded DNA genome with a ...
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33 Herpesviridae - microbewiki - Kenyon College
https://microbewiki.kenyon.edu/index.php/Herpesviridae
Herpesviridae · 1 Baltimore Classification. 1.1 Higher order taxa; 1.2 Genera · 2 Description and Significance · 3 Genome Structure · 4 Virion ...
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34 HSV-1 Hijacks the Host DNA Damage Response in Corneal ...
https://iovs.arvojournals.org/article.aspx?articleid=2770144
Purpose: Herpes simplex virus type I (HSV-1) infection of corneal epithelial cells activates ataxia telangiectasia mutated (ATM), an apical kinase in the ...
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35 Herpes Simplex Virus Latency: The DNA Repair-Centered ...
https://www.hindawi.com/journals/av/2017/7028194/
Like all herpesviruses, herpes simplex virus 1 (HSV1) is able to produce lytic or latent infections depending on the host cell type. Lytic infections occur in a ...
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36 DNA processing by the Kaposi's sarcoma-associated ... - bioRxiv
https://www.biorxiv.org/content/10.1101/2022.09.19.508573v1.full
In HSV-1, the AE (UL12) interacts with the viral single stranded DNA binding protein ICP8 to promote strand exchange (15, 50), like a Redα/Redβ ...
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37 Structure of a herpesvirus - YouTube
https://www.youtube.com/watch?v=VDfa5vCc6B0
Sep 17, 2019
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38 Nucleocapsid Structure, Assembly and DNA Packaging of ...
https://www.caister.com/hsp/abstracts/alphaherpesviruses/10.html
The capsid shell consists of four major structural proteins VP5, VP19C, VP23 and VP26 which are the products of the HSV UL19, UL38, UL18 and UL35 genes. In ...
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39 Herpesviruses Overview: Structure, Classification ... - Cusabio
https://www.cusabio.com/infectious-diseases/herpesviruses.html
The herpesvirus genome consists of a non-segmented, linear, double-stranded DNA molecule. Genome lengths range from approximately 120 to 250 kbp and encode for ...
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40 Virology, pathogenesis, and epidemiology of human ...
https://www.uptodate.com/contents/virology-pathogenesis-and-epidemiology-of-human-herpesvirus-6-infection
As with other herpes viruses, mature HHV-6 virions are double-stranded deoxyribonucleic acid (DNA) viruses, approximately 200 nm in diameter and ...
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41 9.11C: Double-Stranded DNA Viruses - Herpesviruses
https://bio.libretexts.org/Bookshelves/Microbiology/Book%3A_Microbiology_(Boundless)/9%3A_Viruses/9._11%3A_DNA_Viruses_in_Eukaryotes/9.11C%3A_Double-Stranded_DNA_Viruses_-_Herpesviruses
The structure of herpes viruses consists of a relatively large double-stranded, linear DNA genome encased within an icosahedral protein cage ...
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42 Analysis of Herpesvirus DNA Substructure by means of ...
https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-30-2-243?crawler=true
DNA isolated from herpes simplex type 1 (HSV-I) and herpes simplex virus type 2 (HSV-2) consists of linear duplex molecules with mol. wt. of 95 to 100 × 10 6 ( ...
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43 Structure of Simian Virus 40 DNA Replicated by Herpes ...
https://core.ac.uk/download/pdf/82342420.pdf
Replicating herpes simplex virus type 1 (HSV-1) DNA is known to form large branched structures. The aim of this study was to define whether HSV-1-specific ...
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44 Tetranucleotide Profile of Herpesvirus DNA - Filatov
https://microbiol.crie.ru/jour/article/view/825
Results. Minimum CTAG concentration in DNA of herpes viruses is mainly characteristic of two- and singlesegment genomes with direct or inverted terminal repeats ...
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45 Disruption of the interactions between the subunits of ...
https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(14)62273-4/pdf
their importance for virus replication, several interactions between virus proteins have been proposed ... cidofovir, all of which inhibit herpesvirus DNA.
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46 The Genome of Herpes Simplex Virus: Structure, Replication ...
https://journals.biologists.com/jcs/article/1987/Supplement_7/67/58062/The-Genome-of-Herpes-Simplex-Virus-Structure
We are in the late stages of determining the complete sequence of the DNA of HSV-1, which contains about 155 000 base pairs, and thus the ...
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47 Formation of a DNA triple helical structure at BOLF1 gene of ...
https://www.tandfonline.com/doi/abs/10.1080/07391102.2020.1764390
Journal of Biomolecular Structure and Dynamics · Formation of a DNA triple helical structure at BOLF1 gene of human herpesvirus 4 (HH4) genome · Formation of a ...
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48 Alphaherpesvirus DNA replication (Chapter 10) - Human ...
https://www.cambridge.org/core/books/human-herpesviruses/alphaherpesvirus-dna-replication/F568FC33BE3E2F545FE086DA634B8DD6
All alphaherpesvirus genomes contain four general structural components: unique long and short (UL, US) sequences that encode single-copy genes and inverted ...
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49 HERPESVIRUS GENES: MOLECULAR BASIS OF VIRAL ...
https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5934/NJ590303107.pdf
HSV DNA. TRL. UL. IRL IRs. Us. TRs. L component (82%). S component (18%) I. Fig. 1. Structure of Herpes Simplex Virus DNA virion envelope with the plasma ...
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50 virion | viral structure - Encyclopedia Britannica
https://www.britannica.com/science/virion
The capsid itself is surrounded by a lipid envelope containing glycoprotein spikes. Herpesviruses have genomes consisting of linear double-stranded DNA, which ...
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51 High resolution structure of hexameric herpesvirus DNA ...
https://d-nb.info/1213626382/34
when the full-length of the herpesvirus genome is packaged. STRUCTURAL EVIDENCE ... Elucidation of the structure-of the DNA packaging motor of herpesvirus.
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52 Genetics of HSV DNA Replication - Sandra Weller - Grantome
https://grantome.com/grant/NIH/R01-AI021747-35
Several lines of evidence suggest that HSV promotes a unique form of DNA replication that utilizes a recombination-dependent mechanism to produce concatemers.
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53 Herpesvirus DNA polymerases: Structures, functions and ...
https://agris.fao.org/agris-search/search.do?recordID=US201700149293
Human herpesviruses are large double-stranded DNA viruses belonging to the Herpesviridae family. These viruses have the ability to establish lifelong ...
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54 Architecture of the herpesvirus genomepackaging complex ...
http://www.protein-cell.org/en/article/doi/10.1007/s13238-020-00710-0
We report atomic structures of a herpesvirus hexameric terminase complex in both the apo and ADP·BeF3-bound states. Each subunit of the hexameric ring comprises ...
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55 Herpesvirus Replication
https://web.stanford.edu/group/virus/1999/inesicle/replication.html
The linear genome enters the nucleus and circularizes. (4) Once in the nucleus, the viral DNA is transcribed into mRNA by cellular RNA ...
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56 Herpes Simplex Virus | Herpesvirus Classification | HSV-1
https://www.sqadia.com/programs/herpes-simplex-virus
A herpesvirus is a double-stranded DNA virus with icosahedral core and a lipoprotein envelope. Herpesvirus replicates within the host cell nucleus. The ...
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57 Replication of Herpes Simplex Virus - Sumanas, Inc.
https://www.sumanasinc.com/webcontent/animations/content/herpessimplex.html
Microbial Life is available from Oxford University Press. Animation © 2002 Sinauer Associates and Sumanas, Inc. KEYWORDS: Herpes virus, HSV type I, DNA virus ...
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58 Herpes simplex virus replication Steps | Pearson+ Channels
https://www.pearson.com/channels/biology/asset/b8c5dd1a/herpes-simplex-virus-replication-steps-microbiology-animations
Herpes simplex virus replication Steps - Microbiology Animations. ... Virology 2014 lecture #7 - Viral DNA replication. by Vincent Racaniello. 21 views.
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59 Herpes: Symptoms, Causes, Treatment, and More - Healthline
https://www.healthline.com/health/herpes-simplex
The herpes simplex virus, also known as HSV, is a viral infection that causes genital ... The two different types of HSV share similar DNA.
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60 DNA Virus: Replication & Examples - Video & Lesson Transcript
https://study.com/learn/lesson/dna-virus-examples-viral-replication.html
These viral proteins help build the virus. After the viral genome is replicated, assembly occurs. This is when the viral DNA and structural ...
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61 Replay launches big DNA HSV gene therapy company ...
https://www.yahoo.com/now/replay-launches-big-dna-hsv-120000144.html
Replay's distinctive corporate structure separates technology development from product development within disease therapeutic area-focused ...
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62 HSV-1 interactome - Polygenic Pathways
http://www.polygenicpathways.co.uk/herpeshost.html
Dr Wagner's Animations of steps of HSV Infection and Replication ... Unphosphorylated BAF inhibits viral DNA replication and gene expression ...
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63 DNA-VIRUSES. ADENOVIRUSES. HERPESVIRUSES.
https://slideplayer.com/slide/6828289/
38 All herpesviruses have a core of double-stranded DNA surrounded by a protein coat that exhibits icosahedral symmetry and has 162 capsomeres. The nucleocapsid ...
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64 KEGG PATHWAY Database
https://www.genome.jp/kegg/pathway.html
03230: Viral genome structure; 03240: Viral replication; 03250: Viral life cycle - HIV-1 ... 05167 N: Kaposi sarcoma-associated herpesvirus infection ...
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65 DNA replication, disease & medicine - The Scientist
https://www.the-scientist.com/tag/dna-replication,disease-medicine
The latest news and opinions in DNA replication, disease & medicine from The ... with an adeno-associated virus and a helper adeno- or herpesvirus, ...
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66 Replay launches gene therapy company Telaria for skin ...
https://www.labiotech.eu/trends-news/hsv-gene-therapy-company-telaria-skin-diseases/
New Replay HSV gene therapy company Telaria to focus on skin diseases ... Replay's distinctive corporate structure separates technology ...
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67 BioRender
https://biorender.com/
Figure: During HSV infection, memory CD4-T-cells respond to antigens in neural tissue by secreting IFN-γ and loosening tight junctions between endothelial ...
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68 Definition of mucosa - NCI Dictionary of Cancer Terms
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/mucosa
› cancer-terms › def › mucosa
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69 Replay Launches First 'Spoke' Companies
https://www.sdbj.com/biotech/replay-launches-first-spoke-companies/
BIOTECH: Eudora, Telaria Utilize Next-Gen HSV Delivery ... Replay's distinctive hub-and-spoke corporate structure separates technology ...
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70 similarities between dna polymerase 1 and 3
https://thepedlarcafe.com/dpprcyk/similarities-between-dna-polymerase-1-and-3
The replication of DNA viruses occurs inside the hosts nucleus while ... viruses included herpesviruses, papillomaviruses, polyomaviruses, ...
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71 Viruses News - ScienceDaily
https://www.sciencedaily.com/news/health_medicine/viruses/
Read the latest medical research on virology, from herpes virus to ebola virus and ... replication-defective DNA virus vaccine that uses a compound known as ...
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72 Herpesvirus DNA: Recent Studies on the Organization of Viral ...
https://books.google.com/books?id=SuERIYGCEQQC&pg=PA30&lpg=PA30&dq=herpesvirus+dna+structure&source=bl&ots=0GL6HefG_t&sig=ACfU3U1aCUs1U5xsXkvIdACx7VwmPtL14w&hl=en&sa=X&ved=2ahUKEwil3c2W39T7AhXfTaQEHXcKCHwQ6AF6BAgtEAM
Recent Studies on the Organization of Viral Genomes, MRNA Transcription, DNA Replication, Defective DNA, and Viral DNA Sequences in Transformed Cells and ...
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73 National Cancer Program Research Objective: Working Group ...
https://books.google.com/books?id=xuMmTMfW2wAC&pg=RA2-PA98&lpg=RA2-PA98&dq=herpesvirus+dna+structure&source=bl&ots=NMeHOJ7CHC&sig=ACfU3U17i-d9IQeQFsdHKoh-kHQi1CGGhg&hl=en&sa=X&ved=2ahUKEwil3c2W39T7AhXfTaQEHXcKCHwQ6AF6BAgrEAM
Obtain DNA from herpesviruses in sufficient quantities . ... and nononcogenic herpesvirus , indication of correlates between oncogenesis and DNA structure .
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74 Lecithin and hsv2 - Rügen Sterne Hotels
https://ruegensternehotels.de/lecithin-and-hsv2.html
What is Lecithin And Hsv2. HSV 1 vs HSV 2 The herpes simplex virus is one of the ... sulfated polysaccharides help prevent replication of these viruses.
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75 Biomedical Index to PHS-supported Research
https://books.google.com/books?id=w5NrAAAAMAAJ&pg=PA567&lpg=PA567&dq=herpesvirus+dna+structure&source=bl&ots=paCIougQ3T&sig=ACfU3U0BBX1uFgbT4ijulLJPD2Gby1qUGA&hl=en&sa=X&ved=2ahUKEwil3c2W39T7AhXfTaQEHXcKCHwQ6AF6BAgsEAM
S0000105 DNA transactions and aging - Cloning ** PO1AG - 04727-07 0013 Aging cell and tissues - Structure and regulation of eukaryotic initiation factor .
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76 Subject Index of Current Extramural Research Administered by ...
https://books.google.com/books?id=XP1n-_xs0mIC&pg=PA433&lpg=PA433&dq=herpesvirus+dna+structure&source=bl&ots=zuxM3tAvFy&sig=ACfU3U0ikOzTMjU0Lwgxe_9b5-8C0drieg&hl=en&sa=X&ved=2ahUKEwil3c2W39T7AhXfTaQEHXcKCHwQ6AF6BAgzEAM
... ROICA - 26314-01 Post - replication - repair of DNA in EBV genome ( human ) ... of Chicago cancer research center - Expression of HSV DNA sequences in 4 ...
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77 DNA Structure and Function - Page 167 - Google Books Result
https://books.google.com/books?id=Q6Yd-qYvx9UC&pg=PA167&lpg=PA167&dq=herpesvirus+dna+structure&source=bl&ots=Xk1JZmUifh&sig=ACfU3U1sXHF0v6Gb7OrNrIapI5sFahRRkQ&hl=en&sa=X&ved=2ahUKEwil3c2W39T7AhXfTaQEHXcKCHwQ6AF6BAgxEAM
PT181a HSV - oriLb HSV - orisb EBVd ... Table 4.2 Palindromic Replication Origins Origin ¢ X - 174 G4a SV40 Sequence III ...
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78 Research Awards Index - Volume 1 - Page 968 - Google Books Result
https://books.google.com/books?id=s8sZ5Y9galYC&pg=PA968&lpg=PA968&dq=herpesvirus+dna+structure&source=bl&ots=bZhrBOCDjz&sig=ACfU3U1JH_P3DXynqsEZrdJZHmVPezglew&hl=en&sa=X&ved=2ahUKEwil3c2W39T7AhXfTaQEHXcKCHwQ6AF6BAgyEAM
... RO1A1-11520-02 Gene expression and DNA structure of RROICA - 17128-02 ... Molecular biology of Herpesvirus saimiri ROINS - 13045-01 Pathogenesis of slow ...
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79 Dozens of viruses seem to use a different DNA base
https://arstechnica.com/science/2021/04/lots-of-viruses-have-a-distinct-form-of-dna-with-its-own-base/
Image of two chemical structures. Enlarge / Normal DNA uses adenine (left), while some viruses use diaminopurine instead.
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80 Face dna test free - michaelskibbe.de
https://michaelskibbe.de/face-dna-test-free.htm
Other names: herpes culture, herpes simplex viral culture, HSV-1 antibodies, HSV-2 antibodies, HSV DNA. From Business: Accugen Lab is a network of ...
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