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1 Causes of Restless Legs Syndrome (RLS)
https://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/restless-legs-syndrome/what-is-rls/causes.html
Marked improvement in RLS symptoms seen with drugs that stimulate the dopamine system and RLS-like symptoms produced with drug that block the dopamine system ...
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2 Peripheral Dopamine in Restless Legs Syndrome - PMC - NCBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862810/
Dopamine is needed to produce smooth, purposeful muscle activity and movement. Disruption of these pathways frequently results in involuntary movements.
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3 Restless legs syndrome - Illnesses & conditions - NHS inform
https://www.nhsinform.scot/illnesses-and-conditions/brain-nerves-and-spinal-cord/restless-legs-syndrome
If nerve cells become damaged, the amount of dopamine in the brain is reduced, which causes muscle spasms and involuntary movements. Dopamine levels naturally ...
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4 How credible are the proposed theories of Restless leg ...
https://www.entvoicesnoring.com/articles/2019/11/15/how-credible-are-the-proposed-theories-of-restless-leg-syndrome-pathophysiology-discuss-and-critically-evaluate-the-evidence
Although a baseline hyperdopaminergic state exists, there is a circadian pattern to dopaminergic activity in restless leg syndrome, with a ...
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5 Restless legs syndrome: An overview of pathophysiology ...
https://www.spandidos-publications.com/10.3892/etm.2021.11108
Administering a low dose of dopamine at night may be an apparent relief for the patient but it goes in a slippery-slope mechanism of increasing ...
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6 Restless Legs Syndrome: From Pathophysiology to Clinical ...
https://www.frontiersin.org/articles/10.3389/fnagi.2017.00171/full
Iron deficiency in end-stage renal disease patients may lead to anemia and affect the dopamine metabolism, contributing to RLS (Nikic et al., ...
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7 Restless legs syndrome - Pulmonology Advisor
https://www.pulmonologyadvisor.com/home/decision-support-in-medicine/pulmonary-medicine/restless-legs-syndrome/
RLS patients have brain iron deficiency despite a normal systemic iron status, which leads to dopamine dysfunction that produces the RLS ...
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8 Management of restless legs syndrome and periodic limb ...
https://www.uptodate.com/contents/management-of-restless-legs-syndrome-and-periodic-limb-movement-disorder-in-adults
Dopamine agonists — The non-ergot dopamine agonists, pramipexole, ropinirole, and rotigotine, are effective in the treatment of RLS at low doses ...
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9 Support for dopaminergic hypoactivity in restless legs syndrome
https://academic.oup.com/brain/article/129/8/2017/334696
Clinical observations support a central role of the dopamine system in restless legs syndrome (RLS) but previous imaging studies of striatal dopamine D2- ...
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10 Possible Sites of Therapeutic Action in Restless Legs ...
https://www.karger.com/Article/Fulltext/328431
Dopaminergic drugs have shown efficacy as an RLS treatment in numerous large-scale clinical studies [17], and dopamine agonists improve RLS ...
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11 Restless legs syndrome and related disorders - Mount Sinai
https://www.mountsinai.org/health-library/report/restless-legs-syndrome-and-related-disorders
Several studies support the theory that an imbalance in neurotransmitters (chemical messengers in the brain), notably dopamine, may play a part in RLS. Dopamine ...
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12 The night time hustle: managing restless legs syndrome in ...
https://bpac.org.nz/bpj/2012/december/restlesslegs.aspx
Dopaminergic dysfunction and iron deficiency are both thought to have a role in restless legs syndrome. ... The syndrome is also strongly associated with ...
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13 Restless Legs Syndrome Treatments & Medications - WebMD
https://www.webmd.com/brain/restless-legs-syndrome/restless-leg-syndrome-treatment
Dopaminergic agents: These drugs, including Sinemet -- a combination of levodopa and carbidopa -- increase the level of dopamine in the brain and may improve ...
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14 Restless Legs Syndrome - AAFP
https://www.aafp.org/pubs/afp/issues/2008/0715/p235.html
If medications are needed, dopamine agonists are the primary medications for moderate to severe restless legs syndrome.
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15 New Research Identifies Adenosine Role in RLS
http://rlsfoundation.blogspot.com/2018/07/new-research-identifies-adenosine-role.html
It has long been believed that RLS is related to a malfunction in the way the brain uses dopamine. Dopamine is a neurotransmitter (a brain ...
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16 The Management of Restless Legs Syndrome: An Updated ...
https://www.mayoclinicproceedings.org/article/S0025-6196(20)31489-0/fulltext
The choice of an alpha2-delta ligand as first-line therapy for chronic persistent RLS with dopamine agonists as a second-line option is ...
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17 Long-term Treatment of Restless Legs Syndrome With ...
https://jamanetwork.com/journals/jamaneurology/fullarticle/786586
Conclusions Dopamine agonists continued to effectively treat RLS without long-term adverse events but often required adjustments across time. The higher rate of ...
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18 Restless Leg Syndrome and Parkinson's Disease | APDA
https://www.apdaparkinson.org/article/restless-leg-syndrome/
Restless Legs Syndrome (RLS) is a neurologic and sleep-related condition characterized by an irresistible urge to move the legs. The symptoms respond to ...
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19 Restless legs syndrome - Diagnosis and treatment - Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/restless-legs-syndrome/diagnosis-treatment/drc-20377174
Sometimes dopamine medications that have worked for a while to relieve your RLS become ineffective, or you notice your symptoms returning ...
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20 The Link Between Iron Deficiency and Restless Leg Syndrome
https://veincenterelpaso.com/post/the-link-between-iron-deficiency-and-restless-leg-syndrome
Research shows that RLS symptoms are directly related to how well your brain produces and uses dopamine. When iron levels are low, the brain can ...
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21 Dopamine Agonists to Treat Restless Legs Syndrome
https://restlesslegssyndrome.sleep-disorders.net/dopamine-agonists
Dopamine agonists are a group of drugs that imitate the brain chemical dopamine. This makes the brain think it is getting enough dopamine. Low ...
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22 Restless Legs Syndrome
https://rarediseases.org/rare-diseases/restless-legs-syndrome/
The exact underlying cause of RLS symptoms is unknown. However, many researchers suggest that abnormalities in a certain neurotransmitter (dopamine) in the ...
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23 Remedies for Restless Legs Syndrome - Dr Wholeness
https://drwholeness.com/blog/remedies-for-restless-leg-syndrome/
One study actually demonstrated a 4x difference between daytime dopamine and night time dopamine levels in people with restless leg syndrome. In ...
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24 Effect of exercise training and dopamine agonists in patients ...
https://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-14-194
A 6-month exercise training regime was as effective as a 6-month low dosage dopamine agonist treatment in reducing restless legs syndrome ...
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25 Dopamine and Iron in Restless Legs Syndrome - Grantome
https://grantome.com/grant/NIH/R01-NS042857-01A1
Like Parkinson's disease, restless legs syndrome is exquisitely sensitive to dopamine agents and aggravated or precipitated by dopamine antagonists.
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26 Dopamine Deficiency: Symptoms, Causes & Treatment
https://my.clevelandclinic.org/health/articles/22588-dopamine-deficiency
Low levels of dopamine have been linked to Parkinson's disease, restless legs syndrome and depression. Low levels of dopamine can make you ...
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27 The Adenosine Hypothesis of Restless Legs Syndrome
https://www.liebertpub.com/doi/10.1089/caff.2019.0001
Counterintuitively, in the frame of a presynaptic hyperdopaminergic state, dopamine agonists, such as pramipexole and ropinirole, are clinically ...
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28 Neurochemistry of Idiopathic Restless Legs Syndrome
https://touchneurology.com/movement-disorders/journal-articles/neurochemistry-of-idiopathic-restless-legs-syndrome/
The excellent therapeutic response of RLS to dopaminergic drugs, together with some neuropathological, neuroimaging, biochemical and ...
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29 Restless Legs Syndrome across the Lifespan - MDPI
https://www.mdpi.com/1660-4601/17/10/3658/htm
The dopamine pathophysiology of RLS finds its fundamentals in the discovery of the dramatic response to dopaminergic agents (first levodopa, in the early 1980s, ...
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30 An Updated Algorithm - Restless Legs Syndrome Foundation
https://www.rls.org/21Algorithm
for treatment of chronic persistent RLS, with dopamine agonists second-line drugs. d Low-dose opioid therapy is indicated for the management of.
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31 Restless Legs Syndrome: clinical features, diagnosis and a ...
https://pn.bmj.com/content/practneurol/17/6/444.full.pdf
RLS symptoms. Dopamine agonists can still be used as first-line therapy, but the dose should be kept as low as possible.
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32 Restless Legs Syndrome | Diagnosis & Treatment - UCHealth
https://www.uchealth.org/diseases-conditions/restless-legs-syndrome/
Dopamine agonist. A dopamine agonist is a drug that mimics the effects of dopamine to relieve restless legs symptoms. Drugs like pramipexole are often the first ...
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33 2-Minute Neuroscience: Restless Legs Syndrome - YouTube
https://www.youtube.com/watch?v=D6WmNTQTAfc
Neuroscientifically Challenged
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34 Symptom Persistence after Iron Normalization in Women with ...
https://www.psychiatryinvestigation.org/m/journal/view.php?number=847
Among possible pathophysiology of primary RLS, brain iron deficiency and central dopamine dysfunction have been suggested. Serum ferritin level ...
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35 Imbalance between thyroid hormones and the dopaminergic ...
https://www.scielo.br/j/clin/a/T8HQX8qrm4t7RCwc6tB36kP/?lang=en
Dopamine (DA), when diminished, plays an important role in the pathophysiology of Restless Legs Syndrome (RLS) when decreased DA levels are a primary condition, ...
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36 Restless Legs Syndrome: Current Concepts about Disease ...
https://tremorjournal.org/article/10.5334/tohm.322/
Pathologically, the most consistent finding is striatal iron deficiency in RLS patients. A host of other biological systems are also altered in ...
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37 Restless Legs Syndrome: A Disorder of Dopamine ...
https://www.reliasmedia.com/articles/122157-restless-legs-syndrome-a-disorder-of-dopamine-neurotransmission
The present study re-investigates the controversial question of whether there exist dopamine neurotransmission abnormalities in RLS and, in contrast to previous ...
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38 Neuroscience for Kids - Restless Legs Syndrome (RLS)
https://faculty.washington.edu/chudler/rls.html
Dopamine deficiency: medications that increase levels of the neurotransmitter dopamine may relieve RLS symptoms. Diagnosis of RLS. There is no blood test or ...
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39 Restless legs syndrome - RCP Journals
https://www.rcpjournals.org/content/clinmedicine/16/4/379
Restless legs syndrome (RLS) is a common neurological movement disorder, ... Despite the lower doses of dopaminergic medication used, the incidence of ICDs ...
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40 The ABCs of RLS: Restless Legs Syndrome - tl;dr pharmacy
https://www.tldrpharmacy.com/content/the-abcs-of-rls-restless-legs-syndrome
Iron and RLS · Low iron concentrations in the substantia nigra (remember, this is a major site for dopamine production) · Decreased ferritin ...
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41 Restless Legs Syndrome and Mood Disorders - Psychiatrist.com
https://www.psychiatrist.com/jcp/bipolar/mood-disorders/mood-disorders-restless-legs-syndrome-willis-ekbom/
59,80 Given the purported involvement of dopamine deficiency in the etiology of RLS, it is logical to presume that medications that decrease or ...
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42 The 11 Best Treatments for Restless Legs Syndrome
https://www.healthline.com/health/restless-leg-syndrome/treatments
Because of the effects RLS can have on your life, treatment is important. Methods of treatment are varied, as the root cause of RLS isn't truly known. For ...
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43 New Insights into the Neurobiology of Restless Legs Syndrome
https://journals.sagepub.com/doi/10.1177/1073858418791763
The dopaminergic profile in RLS patients includes abnormally high cerebrospinal fluid levels of the dopamine metabolite 3-OMD, interpreted to indicate increased ...
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44 Restless Leg Syndrome Medication Treatment Options - Health
https://www.health.com/condition/sleep/medication-for-rls-the-pros-and-cons-of-dopamine-agonists-and-other-treatments
Because RLS seems to be caused by a dopamine shortage in the brain, Requip and Mirapex—taken an hour or two before bed—improve nighttime ...
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45 Restless legs syndrome - Ekbom - 2009 - Wiley Online Library
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2796.2009.02159.x
Dopamine. According to a commonly held view RLS may be due to dysfunction of dopamine cells in the nigro-striatal areas of the brain.
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46 8 Restless Legs Syndrome Triggers | Everyday Health
https://www.everydayhealth.com/sleep-disorders/restless-leg-syndrome/8-restless-legs-syndrome-triggers/
It transmits brain messages, helps control body movements and alters central nervous system function.“Dopamine levels are lower at night, which ...
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47 Nocturnal Restless Arms and Face Improved by Dopamine ...
https://www.e-jsm.org/journal/view.php?number=224
Restless legs syndrome (RLS) is a sensorimotor disease characterized by abnormal sensation in legs and motor restlessness that often has a ...
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48 Restless Legs Syndrome in Children - Stanford Health Care
https://stanfordhealthcare.org/medical-conditions/sleep/pediatric-sleep-disorders/types/restless-legs-syndrome.html
The cause of RLS also likely involved abnormal Dopamine. Dopamine is an important neurochemical in the brain that is involved in sleep, movements (for example ...
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49 RESTLESS LEGS SYNDROME AND PARKINSON'S
https://davisphinneyfoundation.org/restless-legs-syndrome-parkinsons/
As we stated above, many people with RLS have difficulty falling asleep due to their legs' tingling sensations and restlessness. In these cases, ...
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50 Restless Legs Syndrome: How to Fight a Condition That's ...
https://www.muhealth.org/our-stories/restless-legs-syndrome-how-fight-condition-thats-stealing-your-sleep
If iron deficiency is not the cause, there are treatments to lessen the symptoms of restless legs syndrome. Dopamine agonist drugs such as ropinirole and ...
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51 Restless legs syndrome - Australian Prescriber
https://www.nps.org.au/australian-prescriber/articles/restless-legs-syndrome-1
Restless legs syndrome is a common but under-recognised disorder. For patients with mild symptoms, no drug treatment may be necessary. For patients with severe ...
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52 Are Dopamine Agonists Harming RLS Patients? - Sleep Review
https://sleepreviewmag.com/sleep-treatments/pharmaceuticals/prescription-drugs/dopamine-agonists-harm-restless-legs-syndrome-patients/
A new study finds that about 20% of restless legs syndrome patients are prescribed doses of dopamine agonists above the recommended maximum.
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53 Restless legs syndrome, insomnia and brain chemistry
https://www.sciencedaily.com/releases/2013/05/130507134600.htm
Dopamine-related drugs currently used in RLS do work, but many patients eventually lose the drug benefit and require ever higher doses. When the ...
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54 Understanding and Relieving Restless Legs Syndrome
https://www.uspharmacist.com/article/understanding-and-relieving-restless-legs-syndrome
Dopamine is necessary for the successful use of muscles to produce purposeful movement. As in Parkinson's disease, the brain's ability to use ...
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55 Restless legs syndrome - Wikipedia
https://en.wikipedia.org/wiki/Restless_legs_syndrome
Restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED), is generally a long-term disorder that causes a strong urge to move one's legs.
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56 Restless legs syndrome: MedlinePlus Medical Encyclopedia
https://medlineplus.gov/ency/article/000807.htm
No one knows exactly what causes RLS. It may be due to a problem with the way brain cells use dopamine. Dopamine is a brain chemical that helps ...
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57 Restless Legs Syndrome - Baylor College of Medicine
https://www.bcm.edu/healthcare/specialties/neurology/parkinsons-disease-and-movement-disorders/restless-legs-syndrome
A series of other dopamine drugs called agonists (dopamine mimickers) have since been shown to markedly improve RLS symptoms, often more than Sinemet. These ...
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58 Restless leg syndrome - NHS 111 Wales
https://111.wales.nhs.uk/encyclopaedia/r/article/restlesslegsyndrome/
Dopamine levels naturally fall towards the end of the day, which may explain why the symptoms of restless legs syndrome are often worse in the ...
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59 The Treatment and Management of Restless Legs Syndrome
https://www.medscape.org/viewarticle/522010_6
Piribedil, a nonergot D2 and D3 dopamine agonist, is effective even at a low dose of 25 mg/day. ... Cabergoline, a long-acting ergot dopamine agonist, can provide ...
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60 Restless Legs Syndrome - MDPI
https://mdpi-res.com/d_attachment/brainsci/brainsci-12-00118/article_deploy/brainsci-12-00118.pdf?version=1642332928
Keywords: restless legs syndrome; sleep-related movement disorder; ... in low dopaminergic signaling when dopamine levels are ...
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61 Differential Diagnosis and Treatment of Restless Legs ...
https://www.cureus.com/articles/13971-differential-diagnosis-and-treatment-of-restless-legs-syndrome-a-literature-review
Restless legs syndrome (RLS) is a chronic neurological disorder ... severe RLS symptoms that may require a low-dose dopamine agonist to ...
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62 Full article: Restless legs syndrome: differential diagnosis and ...
https://www.tandfonline.com/doi/full/10.2147/cia.s4143
In particular, dopamine dysfunction plays a central role, as suggested by the early observation that dopaminergic drugs are highly effective in ...
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63 Consensus Guidelines on Rodent Models of Restless Legs ...
https://www.semel.ucla.edu/sites/default/files/publications/21_rls_rodent_guidelines_manconi.pdf
International Restless Legs Syndrome Study Group (IRLSSG) ... of dopamine receptor agonists or levodopa ... Low-dose dopamine agonists generally improve.
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64 Restless legs syndrome in Parkinson disease - Nature
https://www.nature.com/articles/s41598-017-10593-7
PD-RLS was common and severer in motor and some non-motor symptoms. Iron deficiency induced by its metabolism dysfunctions in peripheral and ...
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65 Dopamine Agonists and Levodopa in Restless Legs Syndrome
https://www.medscape.com/viewarticle/576144
Background: Dopaminergic agents are the mainstay therapy for the management of restless legs syndrome (RLS). There are no clear guidelines on RLS management ...
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66 Glutamate, Hyperarousal and Restless Legs Syndrome
https://clinicaltrials.gov/ct2/show/NCT01675323
This hyperarousal produces RLS symptoms by overwhelming the normal inhibitory processes needed to decrease sensory and motor cortical ...
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67 Restless Leg Syndrome - Life Extension
https://www.lifeextension.com/protocols/neurological/restless-leg-syndrome
RLS can be classified as primary or secondary; the exact cause of primary RLS is not known, although altered dopamine signaling is thought to play a part, while ...
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68 Restless legs syndrome: Causes, treatments, and home ...
https://www.medicalnewstoday.com/articles/7882
Restless legs syndrome (RLS) may happen because of mental or physical problems, or it may be an adverse effect of some medications. It is also known as Willis- ...
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69 Restless Legs Syndrome | FX Medicine
https://www.fxmedicine.com.au/blog-post/restless-legs-syndrome
Treatment strategies for RLS include correcting iron deficiency, supporting dopamine synthesis and improving relaxation and quality of sleep ...
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70 Restless Legs Syndrome & Periodic Limb Movements During ...
https://www.utmedicalcenter.org/medical-care/medical-services/procedures-treatments/restless-legs-syndrome-periodic-limb-movements-during-sleep/
The cause of RLS may also involve abnormal dopamine metabolism. Dopamine is an important neurochemical in the brain that is involved in sleep and movements (for ...
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71 Dopamine agonists for restless legs syndrome - Cochrane
https://www.cochrane.org/CD006009/MOVEMENT_dopamine-agonists-for-restless-legs-syndrome
Dopamine agonists lead to a larger improvement on the International RLS Severity Rating Scale (IRLS) compared to placebo. Clinicians rated RLS ...
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72 Restless Legs Syndrome - Hormones Matter
http://www.hormonesmatter.com/restless-legs-syndrome/
Levodopa is converted into dopamine in the body, and therefore it was thought that RLS resulted from a deficiency of dopamine, and thus was ...
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73 Restless legs syndrome
https://aasm.org/resources/factsheets/rls.pdf
Restless legs syndrome (RLS) is a sleep-related movement disorder that ... Iron deficiency and all conditions that produce it increase the risk of RLS, ...
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74 Restless Legs Syndrome - Brain Disorders A-Z
https://brainfoundation.org.au/disorders/restless-legs-syndrome/
The major class of medication that helps in restless legs syndrome are those that increase dopamine transmission in the central nervous system. These include ...
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75 Restless Legs Syndrome as the Initial Presentation of Multiple ...
https://www.hindawi.com/journals/crim/2013/290719/
It is associated with several pathological or physiological conditions. Iron metabolism and dysfunctions of the dopaminergic system are the most important ...
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76 Treating Severe Refractory and Augmented Restless Legs ...
https://journal.chestnet.org/article/S0012-3692(22)01008-X/fulltext
Restless legs syndrome (RLS) is a sensory-motor neurologic ... Mild dopaminergic augmentation of RLS symptoms in patients on low doses of ...
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77 Restless Legs Syndrome - 4 Less-Known Causes
https://chriskresser.com/4-little-known-causes-of-restless-legs-syndrome/
Pinpointing the cause of RLS has been an active research topic for years, but the condition is still not fully understood. The symptoms have been convincingly ...
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78 The Real Causes of Restless Legs Syndrome - Dave Asprey
https://daveasprey.com/restless-leg-syndrome-natural-remedies-10-04-19/
The good news is, you can increase your dopamine levels naturally, with the help of certain supplements and foods. Get a daily dose of L-tyrosine, an amino acid ...
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79 Restless legs syndrome - RACGP
https://www.racgp.org.au/getattachment/87576673-c695-48f6-a806-065da7e5fcc7/Restless-legs-syndrome.aspx
to pharmacotherapy (eg. dopamine agonists, levodopa, opioids,. Background. Restless legs syndrome (RLS) is a common, but frequently.
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80 Do I Have Restless Legs Syndrome?
https://www.thensf.org/do-i-have-restless-legs-syndrome/
This part of the brain relies on a chemical called dopamine to signal to the muscles that it's time to act. In normal circumstances, dopamine ...
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81 Restless legs syndrome: Treatment overview - Allen Press
https://meridian.allenpress.com/mhc/article/2/2/37/36883/Restless-legs-syndrome-Treatment-overview
RLS has been linked to iron deficiency in the body, particularly within dopamine containing neurons. ... Magnetic resonance imaging, studies of ...
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82 Restless Legs Syndrome: Symptoms and Treatment
https://www.livescience.com/34791-restless-legs-syndrome-symptoms-treatment.html
In many cases, the cause of RLS is unknown. However, research points to three factors: iron deficiency, lower dopamine production and heredity, ...
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83 Understanding restless legs syndrome - Los Angeles Times
https://www.latimes.com/archives/la-xpm-2010-jun-28-la-he-restless-legs-20100628-story.html
The dopamine connection also helps explain why the condition has such a distinct circadian rhythm, says Allen, who consults for companies that ...
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84 Augmentation in restless legs syndrome - SleepHub
https://sleephub.com.au/augmentation/
A 10 day washout period once dopamine drugs are weaned, where people are on no medication can be considered to evaluate symptoms and determine ...
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85 Restless Legs Syndrome: Pathophysiology and the Role of ...
https://chiro.org/Graphics_Box_ALT-MED/FULL/Restless_Legs_Syndrome.pdf
Patients with RLS have lower levels of dopamine in the substantia nigra and respond to iron administration. Iron, as a cofactor in dopamine production, ...
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86 Restless legs syndrome - Cancer Therapy Advisor
https://www.cancertherapyadvisor.com/home/decision-support-in-medicine/hospital-medicine/restless-legs-syndrome/
RLS patients have brain iron deficiency despite a normal systemic iron status, which leads to dopamine dysfunction that produces the RLS symptoms. Some patients ...
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87 Restless Legs Syndrome Treatments & Medications
https://www.singlecare.com/conditions/restless-leg-syndrome-treatment-and-medications
When all else fails, low doses of opioids can manage symptoms. Dopamine agonists. RLS is believed to be primarily caused by a shortage of ...
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88 Comparison of Pregabalin with Pramipexole for Restless Legs ...
https://www.nejm.org/doi/full/10.1056/nejmoa1303646
Dopaminergic medications relieve symptoms of the restless legs syndrome (RLS) but have the potential to cause iatrogenic worsening ...
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89 What Conditions Are Treated With Dopamine Agonists?
https://www.verywellhealth.com/conditions-treated-with-dopamine-agonists-4797915
Restless Legs Syndrome. Restless legs syndrome (RLS) is associated with low dopamine levels and low iron levels in the corpus striatum, a part ...
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90 Restless Leg Syndrome: Symptoms and Causes
https://www.mattressadvisor.com/restless-leg-syndrome/
Dopamine is involved in purposeful muscle movements, and some RLS patients experience symptoms as a result of a dopamine deficiency. Since long- ...
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91 Can Restless Leg Syndrome Be Cured with the Proper Diet?
https://premierneurologycenter.com/blog/can-restless-leg-syndrome-be-cured-with-the-proper-diet/
Although the exact cause of RLS is unknown, researchers have determined that people with an iron deficiency are more likely to be affected by the disorder.
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92 Functional Medicine Naperville: Restless Legs Syndrome Relief
https://www.napervilleintegratedwellness.com/functional-medicine-naperville/restless-legs-syndrome-relief/
It has become apparent that RLS is caused by a lack of dopamine in the brain. So it would make sense that increasing levels of dopamine in the ...
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93 What is Restless-leg Syndrome? - SuperPharmacy
https://www.superpharmacy.com.au/blog/restless-leg-syndrome
Dopamine deficiency or excess ... Dopamine is a feel-good hormone that helps a part of the brain called the basal ganglia to function at its best.
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94 Severe Restless Legs Syndrome in the Setting of Iron ...
https://californiasleepsociety.org/news/severe-restless-legs-syndrome/
Prior to initiating pharmacotherapy with a dopamine agonist or alpha-2-delta ligand, patients with RLS should be screened for iron deficiency ...
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95 A Clinical Primer on Restless Legs Syndrome: What We Know ...
https://www.ajmc.com/view/a09_12aug_rls_sethi
The pathophysiology of RLS is not fully understood. Dopaminergic dysfunction and brain iron deficiency have long been regarded as the key ...
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96 Uncovering Restless Leg Syndrome Root Causes
https://schoolafm.com/ws_clinical_know/uncovering-restless-leg-syndrome-root-causes/
Research generally points to RLS being caused by imbalanced neurotransmitter action, most typically that of adenosine, dopamine, and glutamate, all potentiated ...
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