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1 Genetic aspects of restless legs syndrome - PMC - NCBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653903/
Conclusions: The present family tree indicates that familial RLS can exhibit a heredity pattern which shows autosomal dominant inheritance. The present family ...
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2 Family Study of Restless Legs Syndrome in Quebec, Canada
https://jamanetwork.com/journals/jamaneurology/fullarticle/800139
Familial RLS is a chronic disorder with a mean (SD) disease duration of 24 (16) years and a wide range of age of onset (mean [SD], 28 [15] years), with most ...
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3 Treatment for Restless Legs Syndrome Focuses on Relieving ...
https://newsnetwork.mayoclinic.org/discussion/treatment-for-restless-legs-syndrome-focuses-on-relieving-the-symptoms/
Restless legs syndrome, or RLS, is not always hereditary. But it does run in some families, and several genetic links have been found for ...
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4 Restless Legs Syndrome
https://rarediseases.org/rare-diseases/restless-legs-syndrome/
In primary RLS, the disorder is often genetic in origin or occurs for unknown reasons (idiopathic). Secondary RLS may occur in association with certain ...
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5 Restless Legs Syndrome: From Pathophysiology to Clinical ...
https://www.frontiersin.org/articles/10.3389/fnagi.2017.00171/full
Restless legs syndrome (RLS), a common neurological sensorimotor disorder in western countries, has gained more and more attention in Asian ...
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6 MEIS1 p.R272H IN FAMILIAL RESTLESS LEGS SYNDROME
https://n.neurology.org/content/73/3/243
Restless legs syndrome (RLS, OMIM 102300) is a neurologic condition characterized by a distressing urge to move the legs, ...
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7 Latest Perspectives in Genetic Risk Factors for Restless Legs ...
https://touchneurology.com/movement-disorders/journal-articles/latest-perspectives-in-genetic-risk-factors-for-restless-legs-syndrome/
A recent family study of RLS involving 671 cases showed familial aggregation with a rate of 77.1 %.8 It has been reported that patients with ...
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8 Childhood restless legs syndrome: A longitudinal study of ...
https://onlinelibrary.wiley.com/doi/abs/10.1111/jsr.13161
The prevalence was higher when there was at least one parent affected with RLS (13.0%) compared to children without a parental history (6.9%).
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9 A direct interaction between two Restless Legs Syndrome ...
https://www.nature.com/articles/s41598-018-30665-6
Restless Legs syndrome (RLS) is a common sleep disorder for which the genetic contribution remains poorly explained.
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10 Genetics of restless legs syndrome | SpringerLink
https://link.springer.com/article/10.1007/s11910-008-0033-y
Restless legs syndrome (RLS) is a highly familial trait with heritability estimates of about 50%. It is a polygenetic disorder in which a ...
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11 Clinical features and diagnosis of restless legs syndrome and ...
https://www.uptodate.com/contents/clinical-features-and-diagnosis-of-restless-legs-syndrome-and-periodic-limb-movement-disorder-in-adults
Restless legs syndrome (RLS), also called Willis-Ekbom disease (WED), is a common sleep-related movement disorder characterized by an often ...
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12 Restless Legs Syndrome Appears to Occur Within Families
https://www.disabled-world.com/health/neurology/sleepdisorders/restlesslegsyndrome/rls-families.php
"Familial restless legs syndrome is a chronic disorder with a mean [average] disease duration of 24 years and a wide range of age of onset ...
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13 Causes and Risk Factors of Restless Legs Syndrome
https://www.verywellhealth.com/restless-legs-syndrome-causes-5069908
The most common cause of restless legs syndrome (RLS) is familial RLS, also known as primary RLS. Primary RLS is heritable and almost ...
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14 Restless Legs Syndrome - Medscape Reference
https://emedicine.medscape.com/article/1188327-overview
Restless legs syndrome (RLS) can be either primary or secondary. In most cases, RLS is a primary, idiopathic central nervous system (CNS) ...
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15 0825 A Case of Familial Restless Legs Syndrome and ...
https://academic.oup.com/sleep/article/45/Supplement_1/A356/6593090
Restless legs syndrome (RLS) is a common sensory-motor disorder that frequently leads to sleep disturbances and reduced quality of life.
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16 Restless Legs Syndrome Article - StatPearls
https://www.statpearls.com/ArticleLibrary/viewarticle/28429
[1] Commonly, RLS is a primary central nervous system (CNS) disorder. This idiopathic disease may be familial in 25-75% of patients. In familial ...
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17 Gene Linked to Restless Leg Syndrome Found - ABC News
https://abcnews.go.com/Health/Healthday/story?id=4507985&page=1
"There is a strong familial and genetic basis to restless legs syndrome," said the author of an accompanying editorial, Dr. John Winkelman, medical director ...
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18 Entry - %612853 - RESTLESS LEGS SYNDROME ... - OMIM
https://www.omim.org/entry/612853
Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, ...
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19 KEGG DISEASE: Restless legs syndrome
https://www.genome.jp/entry/H01597
RLS has a high familial aggregation. To date, several loci and genetic risk factors have been identified, but no causative gene mutation has been found.
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20 Restless legs syndrome
https://jnnp.bmj.com/content/jnnp/71/2/143.full.pdf
EDITORIAL. Restless legs syndrome. The term restless legs syndrome (RLS) was first intro- ... in a patient with familial RLS.16 A high resolution fMRI.
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21 Association of Familial Ataxia and Restless Legs Syndrome
https://neuro.psychiatryonline.org/doi/full/10.1176/jnp.2007.19.2.204
SIR: Restless legs syndrome (RLS), characterized by an intense urge to move the lower extremities especially during the night, is associated ...
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22 Restless legs syndrome - Wikipedia
https://en.wikipedia.org/wiki/Restless_legs_syndrome
Restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED), is generally a long-term disorder that causes a strong urge to move one's legs.
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23 Restless Legs Syndrome (RLS) - DynaMed
https://www.dynamed.com/condition/restless-legs-syndrome-rls
no known underlying cause or condition · often familial and usually presents in patients < 30 years old · typically slow development over time and chronic course ...
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24 Variable expressivity in familial restless legs syndrome.
http://psycnet.apa.org/record/1991-13120-001
Presents an unusual restless legs syndrome (RLS) family in which a 62-yr-old male obligate carrier for the RLS gene gave no history suggestive of motor ...
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25 Restless Legs Syndrome (RLS): Causes, Symptoms, Diagnosis
https://my.clevelandclinic.org/health/diseases/9497-restless-legs-syndrome
Restless legs syndrome (RLS) has been found to be a genetic syndrome in some cases, meaning that parents with RLS can pass it down to their ...
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26 Restless Legs Syndrome: A Clinical Study of 55 Patients
https://www.karger.com/Article/Abstract/52098
Early-onset RLS was more commonly familial (p = 0.01) and associated with 'growing pains' (p = 0.005) than late-onset RLS. Patients with RLS and ...
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27 The Impact of Restless Legs Syndrome: A Familial Case Study
https://www.nursingcenter.com/journalarticle?Article_ID=1628076&Journal_ID=828525&Issue_ID=1627662
RLS has a general population incidence of between 5% and 10% and a familial rate as high as 77%. This case study examines the pathophysiology, diagnosis, and ...
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28 Restless legs syndrome - RCP Journals
https://www.rcpjournals.org/content/clinmedicine/16/4/379
There are several reports of RLS occurring in families, which suggest an autosomal dominant mode of inheritance with variable expression and possible ...
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29 Familial RLS with Nocturnal Eating
https://www.anncaserep.com/open-access/familial-rls-with-nocturnal-eating-case-report-and-review-8355.pdf
Restless Leg Syndrome (RLS) is a common neurological disorder, which disrupts life and sleep considerably for those who have it.
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30 Familial Restless Legs Syndrome - Archives of Iranian Medicine
http://www.aimjournal.ir/PDF/82_feb017_009.pdf
Background: Restless legs syndrome (RLS) is a chronic condition ... Conclusions: The present family tree indicates that familial RLS can exhibit a heredity ...
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31 Severity and frequency of restless legs syndrome in patients ...
https://journals.sagepub.com/doi/pdf/10.1177/0300060517704789
Familial Mediterranean fever (FMF) is an inherited inflammatory disease characterized ... Familial Mediterranean fever, restless legs syndrome, association.
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32 Restless legs syndrome: is it all in the genes? - The Lancet
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30330-7/fulltext
Familial aggregation of restless legs syndrome has long been recognised, particularly in patients in whom the disorder manifests before age 40 ...
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33 How credible are the proposed theories of Restless leg ...
https://www.entvoicesnoring.com/articles/2019/11/15/how-credible-are-the-proposed-theories-of-restless-leg-syndrome-pathophysiology-discuss-and-critically-evaluate-the-evidence
The first is a familial, early-onset or primary restless leg syndrome with a peak incidence of 20-40 years. The second is a late-onset ...
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34 Restless legs syndrome: French-Canadian families at higher risk
https://www.sciencedaily.com/releases/2010/05/100510161302.htm
Restless legs syndrome, which causes an irresistible desire to move legs, appears to be a hereditary condition that's more prominent among ...
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35 Restless Legs Syndrome: A Common, Underdiagnosed ...
https://www.uspharmacist.com/article/restless-legs-syndrome-a-common-underdiagnosed-disorder
The cause of RLS remains unclear, but research suggests that impaired dopamine activity in the brain due to iron insufficiency may induce RLS in ...
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36 Familial and single cases of restless leg syndrome¶
https://cms.gulhanemedj.org/Uploads/Article_34458/GMJ-53-77-En.pdf
of the family. In addition to familial cases presented above a single case with restless leg syndrome is presented. A 26-year-old male complained.
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37 Linking restless legs syndrome with Parkinson's disease
https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/2047-9158-1-6
There is a single report of a PD patient with a PINK1 mutation presenting with RLS symptoms [40]. A family with hereditary PD, essential tremor ...
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38 Restless Legs Syndrome: Detection and Management ... - AAFP
https://www.aafp.org/pubs/afp/issues/2000/0701/p108.html
Restless legs syndrome (RLS) is a neurologic movement disorder that is often associated with a sleep complaint. Patients with RLS have an ...
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39 Restless Legs Syndrome (RLS) - News Medical
https://www.news-medical.net/health/Restless-Legs-Syndrome-(RLS).aspx
There is no clear identifiable cause for most individuals with restless legs syndrome. It can have a familial link in some cases, but many individuals with ...
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40 Restless Legs Syndrome: A Review | CNS Spectrums
https://www.cambridge.org/core/journals/cns-spectrums/article/restless-legs-syndrome-a-review/48A25984332DCC1C772600E9F96D8C2B
RLS is common and most severe among females and the elderly. It may be primary or secondary to other conditions and may be familial. Linkage to several ...
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41 Prevalence and associated comorbidities of restless legs ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172593
Restless legs syndrome (RLS), also known as Willis–Ekbom disease, is a common sensorimotor neurological syndrome which is clinically ...
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42 Evaluation of Restless Legs syndrome and growing pains in ...
https://www.researchgate.net/publication/328308514_Evaluation_of_Restless_Legs_syndrome_and_growing_pains_in_children_with_familial_Mediterranean_f
These two pain syndromes -GP and RLS- may be confused with exertional leg pain (ELP) of familial Mediterranean fever (FMF). The aim of this ...
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43 Analysis of familial and sporadic restless legs syndrome in ...
https://search.proquest.com/openview/0b4f05b8d86e68327ef6dc1b885d3076/1.pdf?pq-origsite=gscholar&cbl=47196
Analysis of familial and sporadic restless legs syndrome in age of onset, gender, and severity features only 3 % of the polled participants diagnosed by a ...
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44 Restless legs syndrome | Hirslanden Switzerland
https://www.hirslanden.com/en/international/disease-patterns/restless-legs-syndrome.html
Familial predisposition is common in the case of this disease, so genetic factors seem to play a part. Restless legs syndrome is quite common.
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45 Restless Leg Syndrome and Periodic Limb Movement Disorders
https://www.cincinnatichildrens.org/health/r/restless-leg-syndrome-periodic-limb-movement-disorders
One study suggests that almost half of adults with restless leg syndrome have their first symptoms during childhood. Children with ADHD or children with iron ...
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46 Restless legs syndrome: Causes, treatments, and home ...
https://www.medicalnewstoday.com/articles/7882
Fast facts on restless legs syndrome: · RLS can is classed as either primary or secondary. · Many people can treat the issues at home. · The condition is often ...
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47 Epidemiology of Restless Legs Symptoms in Adults
https://sleepcohort.wisc.edu/wp-content/uploads/sites/1452/2020/10/rls_barb.pdf
Background: Restless legs syndrome (RLS) is a disorder characterizedbysleep-disruptingunpleasantlegsensations, often accompanied by daytime behavioral ...
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48 Frequency, severity and risk factors for restless legs syndrome ...
https://nsj.org.sa/content/nsj/17/3/230.full.pdf
Conclusions: Restless leg syndrome is a treatable disorder; however, it is still widely ... during sleep (PLMS).5,6 Restless legs syndrome familial.
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49 Restless legs syndrome: French-Canadian families at higher risk
https://www.eurekalert.org/pub_releases/2010-05/uom-rls051010.php
"Our findings indicate that familial restless legs syndrome is more prominent among female relatives, particularly those who also have anemia or ...
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50 Restless Leg Syndrome - FamilyDoctor.org
https://familydoctor.org/condition/restless-legs-syndrome/
Doctors don't know what causes RLS. Some cases are related to other conditions, such as pregnancy, iron deficiency anemia, or kidney failure.
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51 Restless leg syndrome: is it a real problem? | TCRM
https://www.dovepress.com/restless-leg-syndrome-is-it-a-real-problem-peer-reviewed-fulltext-article-TCRM
Primary RLS is familial in up to two thirds of patients. RLS may also be secondary to a number of conditions including iron deficiency, ...
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52 Treatment for restless legs syndrome focuses on relieving the ...
https://www.chicagotribune.com/nation-world/ct-xpm-2013-03-04-chi-tms-mayo-restless-legs-story.html
ANSWER: Restless legs syndrome, or RLS, is not always hereditary. But it does run in some families, and several genetic links have been ...
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53 Restless leg syndrome, periodic limb movements, febrile ...
https://annalsofian.org/article.asp?issn=0972-2327;year=2012;volume=15;issue=1;spage=39;epage=43;aulast=Gupta;type=3
It can be idiopathic or associated with various medical and other neurological disorders. Idiopathic RLS can be sporadic or may have a familial inheritance, ...
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54 Restless Legs Syndrome
https://portsmouth.tricare.mil/Portals/130/RLSPatientInfo.pdf
For example, the disorder has the fol- lowing characteristics: • It often runs in families, when it is called primary or familial RLS. • It can appear as the ...
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55 The restless legs syndrome
https://www.tandfonline.com/doi/pdf/10.1163/156856900750228033
The 'restless legs syndrome' is characterized by a complex sensory and motor ... cents.2 Also, familial cases are described.3 It is 30% more frequent in ...
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56 Restless Legs Syndrome across the Lifespan - MDPI
https://www.mdpi.com/1660-4601/17/10/3658/htm
Restless legs syndrome (RLS), also known as Willis–Ekbom disease, is a frequent neurological disorder whose recognition among neurologists is still low, despite ...
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57 A Genetic Risk Factor for Periodic Limb Movements in Sleep
https://www.nejm.org/doi/full/10.1056/NEJMoa072743
The restless legs syndrome (RLS) is a common neurologic disorder characterized by an irresistible urge to move the legs.
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58 A peripheral pathway to restless legs syndrome? Clues from ...
https://www.mdsabstracts.org/abstract/a-peripheral-pathway-to-restless-legs-syndrome-clues-from-familial-amyloid-polyneuropathy/
Conclusions: RLS frequency is increased in TTR-FAP, thus supporting an association between RLS and neuropathy. This may represent a peripheral ...
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59 Willis-Ekbom disease - LITFL.com
https://litfl.com/willis-ekbom-disease/
Restless legs syndrome (RLS)/Willis-Ekbom disease (WED) is characterized by an urge to move the legs, usually associated with limb discomfort.
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60 Neurology, do you know what is restless leg syndrome?
https://www.humanitas.net/health/health-a-z/neurology/2262-neurology-know-restless-leg-syndrome/
The diagnosis of restless leg syndrome is made through a classical neurological examination. This disorder can be primary or secondary. In the ...
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61 Restless legs syndrome: Treatment overview - Allen Press
https://meridian.allenpress.com/mhc/article/2/2/37/36883/Restless-legs-syndrome-Treatment-overview
There is a high frequency of familial cases of RLS consistent with a genetic origin in primary RLS. RLS seems to have a complex genetic basis, ...
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62 The Management of Restless Legs Syndrome: An Updated ...
https://www.mayoclinicproceedings.org/article/S0025-6196(20)31489-0/fulltext
Restless legs syndrome (RLS) is a common disorder. The population prevalence is 1.5% to 2.7% in a subgroup of patients having more severe ...
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63 Restless legs syndrome - Knowledge @ AMBOSS
https://www.amboss.com/us/knowledge/Restless_legs_syndrome/
Restless legs syndrome (RLS), also referred to as Willis-Ekbom disease (WED), is a relatively common, neurological sleep disorder ...
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64 Segregation Analysis of Restless Legs Syndrome - JSTOR
https://www.jstor.org/stable/48506769
with significant residual familial effects and the lack of evi- dence for a major gene controlling age of onset, indicates that non-genetic causes of RLS ...
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65 Genetics of Early Onset Restless Legs Syndrome
https://www.pediatricneurologybriefs.com/article/10.15844/pedneurbriefs-22-3-4/
To date, no gene mutation has been found. RLS is primary or secondary. The primary form is highly familial; secondary RLS is often associated ...
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66 Restless legs syndrome causes - wikidoc
https://www.wikidoc.org/index.php/Restless_legs_syndrome_causes
40% of cases of RLS are familial and are inherited in an autosomal dominant fashion with variable penetrance.
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67 Genetics and Pathogenesis of Restless Legs Syndrome
https://www.medscape.org/viewarticle/572098
Restless legs syndrome (RLS) is a prevalent disorder that has a significant impact on patient quality of life. Recent studies have identified gene variants ...
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68 Restless Legs Syndrome (RLS) - Plano, TX & McKinney, TX
https://www.dallas-sleep.com/contents/services/rls
RLS (Restless Legs Syndrome) is a disruptive neurological disorder that affects approximately 10% of the population. RLS is characterized by uncomfortable and ...
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69 Treating restless legs syndrome - Albuquerque Journal
https://www.abqjournal.com/1228163/treating-restless-legs-syndrome-ex-medication-can-help-as-can-exercise-and-massage.html
In many cases of RLS, the cause is unknown, but RLS appears to be hereditary in about half the people who have it. Familial RLS symptoms often ...
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70 Restless legs syndrome - bionity.com
https://www.bionity.com/en/encyclopedia/Restless_legs_syndrome.html
40% of cases of RLS are familial and are inherited in an autosomal dominant fashion with variable penetrance. No one knows the exact cause of RLS at present.
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71 Restless Legs Syndrome
http://turkishfamilyphysician.com/articles/review/restless-legs-syndrome/
Although primary RLS has a familial component, the underlying mechanism is still not fully understoood. It may be secondary to iron deficiency, ...
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72 An Updated Algorithm - Restless Legs Syndrome Foundation
https://www.rls.org/21Algorithm
cide.6,7 RLS is familial in about 50% of pa- tients8 but may be related to acquired conditions, especially iron deficiency, preg-.
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73 Restless Legs Syndrome: How to Fight a Condition That's ...
https://www.muhealth.org/our-stories/restless-legs-syndrome-how-fight-condition-thats-stealing-your-sleep
There are two types of restless legs syndrome. Primary RLS is commonly hereditary, but the cause is unknown. Treatment focuses on managing the symptoms.
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74 Restless Leg Syndrome | Village Sleep Lab | The Villages, FL
https://www.villagesleeplab.com/restless-leg-syndrome
Restless Legs Syndrome can be familial and usually arises before age 30, often in childhood, where it can be confused with ADHD (Attention Deficit ...
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75 Restless legs syndrome - RACGP
https://www.racgp.org.au/getattachment/87576673-c695-48f6-a806-065da7e5fcc7/Restless-legs-syndrome.aspx
Restless legs syndrome (Rls) is a common, distressing movement disorder, yet many sufferers are not diagnosed or managed adequately. Restless legs syndrome ...
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76 Restless Legs Syndrome as the Initial Presentation of Multiple ...
https://www.hindawi.com/journals/crim/2013/290719/
The restless legs syndrome (RLS) is a common central nervous system disorder. It is characterized by complaints of unpleasant sensation in the legs ...
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77 Sleep Disorder : Restless Legs Syndrome - Medindia
https://www.medindia.net/patients/patientinfo/sleep/restlesslegssyndrome_causes.htm
Genetics: An Icelandic study, in 2005, confirmed the presence of an RLS susceptibility gene. 40% of cases of RLS are familial and are inherited in an autosomal ...
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78 Familial restless leg syndrome in a Filipino family.
https://www.herdin.ph/index.php/herdin-journals?view=research&cid=19305
Familial restless leg syndrome in a Filipino family. Acta Medica Philippina, 24(3), 93-94. Ragrag-Borrinaga , Jane , and Rogelio L. Libarnes .
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79 Restless Legs Syndrome: Causes, Symptoms, Treatment DSM ...
https://thriveboston.com/counseling/restless-legs-syndrome/
RLS also has a strong familial component, so if you know of a relative or two who suffer from RLS, you may have genetic susceptibility. Course ...
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80 Restless legs syndrome - NHS
https://www.nhs.uk/conditions/restless-legs-syndrome/
Restless legs syndrome, also known as Willis-Ekbom disease, is a common condition of the nervous system that causes an overwhelming irresistible urge to ...
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81 Restless Leg Syndrome - Fort Sanders Regional Medical Center
https://www.fsregional.com/sleepdisorder/restless-leg-syndrome/
Is there a known cause for Restless Leg Syndrome? · RLS often runs in families. · RLS sometimes appears to be a result of another condition, which, when present, ...
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82 Understanding Restless Legs Syndrome and Its Causes
https://riovistawellnesscenter.com/blog/111-understanding-restless-legs-syndrome-and-its-causes.html
However, there does seem to be a familial linkage. Researchers have found that about half of the people who suffer from RLS have someone else in the family that ...
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83 Restless legs syndrome (RLS) - MedLink Neurology
https://www.medlink.com/articles/restless-legs-syndrome
The sensory symptoms of restless legs syndrome are paresthesias and dysesthesias in the calves and legs. Descriptions of these phenomena include words such ...
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84 Reviews Restless Legs Syndrome
https://tremorjournal.org/articles/10.5334/tohm.322/galley/463/download/
Restless Legs Syndrome: Current Concepts about Disease Pathophysiology ... RLS is highly familial with estimates of heritability between 54%.
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85 Restless Leg Syndrome & Periodic Limb Movements of Sleep
https://www.archildrens.org/-/media/Files/for-healthcare-professionals/pediatric-guidelines/Movements_in_Sleep_Restless_Leg_Syndrome_Periodic_Limb_Movements_of_Sleep.pdf
Primary RLS or familial RLS is inherited in an autosomal dominant fashion with variable. Page 2. 2 penetrance. Specifically 4 genes, MEIS1, BTBD ...
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86 Restless Leg Syndrome - Sleep Medicine Centers of WNY
http://www.sleepmedicinecenters.com/SleepDisorders/RestlessLegsSyndrome
RLS often runs in families. Researchers are currently looking for the gene or genes that may be responsible for this form of RLS, known as primarily or familial ...
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87 Restless Legs Syndrome Secondary to Sacral Zona Zoster
https://www.jpsmjournal.com/article/S0885-3924(10)01055-9/fulltext
RLS is classified as either primary/familial, which has a clear genetic component, or secondary/symptomatic. Primary RLS usually has an onset ...
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88 Restless Legs Syndrome Treatments & Medications
https://www.singlecare.com/conditions/restless-leg-syndrome-treatment-and-medications
Many RLS symptoms caused by an underlying condition can be resolved. More severe cases of primary or familial RLS can be managed with ...
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89 Genetics of Restless Legs Syndrome - Clinical Gate
https://clinicalgate.com/genetics-of-restless-legs-syndrome/
RLS is not only prevalent in the general population but also aggregates in families. The familial character of RLS has long been recognized ...
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90 Restless Leg Syndrome: Triggers, Home Remedies and ...
https://www.youtube.com/watch?v=tEtepQRWWXY
Cleveland Clinic
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91 Restless Legs Syndrome Guide: Causes and Symptoms of RLS
https://www.masterclass.com/articles/restless-leg-syndrome-guide
2. Genetics and environmental factors: RLS can be hereditary, especially if it surfaces before 40. Researchers have found that specific gene ...
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92 Restless legs syndrome - Cancer Therapy Advisor
https://www.cancertherapyadvisor.com/home/decision-support-in-medicine/hospital-medicine/restless-legs-syndrome/
RLS can be primary with an early onset or secondary with a late onset (>45 yo). Periodic leg movements in sleep are not necessary to make a diagnosis of RLS.
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93 Causes of Restless Legs Syndrome (RLS)
https://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/restless-legs-syndrome/what-is-rls/causes.html
There are many reasons a person might have restless legs syndrome, including genetics, peripheral neuropathies, dialysis, iron deficiency, and many more.
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94 Restless Legs Syndrome Can Have Family Ties
https://consumer.healthday.com/health-technology-information-18/genetics-news-334/restless-legs-syndrome-can-have-family-ties-638977.html
MONDAY, May 10, 2010 (HealthDay News) -- Siblings and family members of people who have restless legs syndrome are also more likely to ...
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