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1 The Role of Histone Deacetylases in Autism Spectrum Disorder
https://advances.massgeneral.org/neuro/journal.aspx?id=2265
This review reports what is known about associations between autism spectrum disorder (ASD) and histone deacetylases (HDACs), enzymes that ...
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2 High-throughput screening identifies histone deacetylase ...
https://molecularautism.biomedcentral.com/articles/10.1186/s13229-020-00387-6
High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum ...
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3 Valproic Acid Induces Autism-Like Synaptic and Behavioral ...
https://www.frontiersin.org/articles/10.3389/fnins.2021.641284/full
This effect suggests that HDAC activity and the level of histone acetylation may be dysregulated in the VPA-induced autism model.
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4 Social deficits in Shank3-deficient mouse models of ... - Nature
https://www.nature.com/articles/s41593-018-0110-8
Here we found that brief treatment with romidepsin, a highly potent class I histone deacetylase (HDAC) inhibitor, alleviated social deficits in ...
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5 An epigenetic target for autism | Science Translational Medicine
https://www.science.org/doi/10.1126/scitranslmed.aat4476
Qin et al. show that romidepsin, a histone deacetylase (HDAC) inhibitor, rescued social behavioral deficits in Shank3-deficient mice by inhibiting excessive ...
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6 Autism-Like Social Deficits Reversed by Epigenetic Drug
https://www.genengnews.com/topics/omics/autism-like-social-deficits-reversed-by-epigenetic-drug/
“The HDAC inhibitor loosens up the densely packed chromatin so that the transcriptional machinery gains access to the promoter area of the genes ...
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7 Autism's link to chromatin remodeling, explained | Spectrum
https://www.spectrumnews.org/news/autisms-link-to-chromatin-remodeling-explained/
Many of the genes strongly linked to autism are involved in the ... Mice lacking SHANK3 have too much of a specific HDAC protein and fewer ...
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8 Histone Acetylome-wide Association Study of Autism ...
https://www.cell.com/cell/pdf/S0092-8674(16)31451-9.pdf
autism spectrum disorder (ASD) has not been sys- tematically examined. ... digestive tract morphogenesis, chemokine signaling, HDAC ac-.
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9 Epigenetics of Autism Spectrum Disorder: Histone Deacetylases
https://www.biologicalpsychiatryjournal.com/article/S0006-3223(21)01832-1/fulltext
HDAC alterations have been found in preclinical and human studies of ASD-associated disorders. AS, Angelman syndrome; CdLS, ...
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10 Study suggests new way to treat rare autism disorder
https://news.vumc.org/2016/08/25/study-suggests-new-way-to-treat-rare-autism-disorder/
The impairments were “normalized” when the mice were given small-molecule drugs called HDAC inhibitors, which alter Tcf4-associated gene ...
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11 HDAC9 structural variants disrupting TWIST1 ... - Genome Res
https://genome.cshlp.org/content/32/7/1242.short
Based on SVs within the HDAC9‐TWIST1 locus, we defined the 3′-HDAC9 sequence as a critical TWIST1 regulatory region, encompassing craniofacial ...
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12 HDAC inhibitor improves social symptoms of autism spectrum ...
https://www.bioworld.com/articles/371978-hdac-inhibitor-improves-social-symptoms-of-autism-spectrum-disorder
Romidepsin, a histone deacetylase (HDAC) inhibitor and FDA-approved lymphoma drug, reversed the social deficits of autism spectrum disorder ...
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13 Convergence of genes and cellular pathways dysregulated in ...
https://scholars.duke.edu/display/pub1028593
Convergence of genes and cellular pathways dysregulated in autism spectrum ... as well as other genes such as SETD5, MIR137, and HDAC9.
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14 Histone Deacetylase 9 - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/medicine-and-dentistry/histone-deacetylase-9
Deletion of HDAC9 in these mice improved adipogenic differentiation and systemic metabolic state, ... learning deficits, and autism-like behaviors in mice.
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15 Treatment with the HDAC inhibitor MS-275 rescues autism ...
https://www.researchgate.net/figure/Treatment-with-the-HDAC-inhibitor-MS-275-rescues-autism-like-social-deficits-in_fig1_324616540
Treatment with the HDAC inhibitor MS-275 rescues autism-like social deficits in Shank3-deficient mice. a Immunoblots and quantification analysis of the ...
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16 Contiguous gene deletion neighboring TWIST1 identified in a ...
https://ern-ithaca.eu/wp-content/uploads/2020/12/Shimbo_SaetChot_molecular_CongAnom2018.pdf
HDAC9 were identified in autism spectrum disorder, developmental delay, and schizophrenia (Pinto et al. 2014). Among the genes.
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17 Human gut bacteria as potent class I histone deacetylase ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201073
Overexpression of histone deacetylase (HDAC) isoforms has been ... New evidences on the altered gut microbiota in autism spectrum disorders.
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18 Regulation of class IIa HDAC activities: it is not only matter of ...
https://www.futuremedicine.com/doi/10.2217/epi.15.106
To the subclass IIa belong HDAC4, HDAC5, HDAC7 and HDAC9 (for an excellent review on HDACs see [2]). These proteins share specific and ...
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19 An Epigenetic Approach to Autism - NEJM Journal Watch
https://www.jwatch.org/na46569/2018/05/03/epigenetic-approach-autism
In Shank3-deficient mice, but not wild-type mice, the histone deacetylase (HDAC) inhibitor romidepsin increased H3 acetylation, social ...
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20 Association of genes with phenotype in autism spectrum ...
https://www.aging-us.com/article/102473
The considerable significance of the genetics associated with autism has led to the ... HDAC: histone deacetylase 4; HDAC9: histone deacetylase 9; ...
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21 Recent ultra-rare inherited mutations identify novel autism ...
https://www.biorxiv.org/content/10.1101/2020.02.10.932327v1.full.pdf
Here, we show that craniosynostosis patients with SVs containing the Histone deacetylase 9 (HDAC9) protein-coding sequence are associated with ...
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22 Food Bioactive HDAC Inhibitors in the Epigenetic Regulation ...
https://www.mdpi.com/2072-6643/10/8/1120
It has been reported that histone deacetylase (HDAC) activity is elevated in models of cardiac remodeling [9,10,11,12]. However, its activity in human heart ...
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23 Age and Alzheimer's Related Brain Decline Linked to Little ...
https://neurosciencenews.com/hdac-age-alzheimers-20408/
The HDAC9 enzyme appears to play a critical role in learning and neural communication. Decreased expression of HDAC9 in the hippocampus and ...
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24 Isotype-Specific Inhibition of Histone Deacetylases
https://www.e-crt.org/journal/view.php?number=2513
Histone deacetylase (HDAC) inhibitors radiosensitize tumor cells. To elucidate mechanisms underlying radiosensitization by HDAC inhibition, ...
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25 New study implicates role of HDAC9 gene in calcification of ...
https://www.news-medical.net/news/20191029/New-study-implicates-role-of-HDAC9-gene-in-calcification-of-the-human-aorta.aspx
This high-risk variant of HDAC9 is present in about 25 percent of the ... Gene mutation associated with autism causes an overstimulation of ...
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26 Cancer Drug Reverses Social Defects of Autism in Model
https://www.labroots.com/trending/genetics-and-genomics/8266/cancer-drug-reverses-social-defects-autism-model
Histone deacetylases (HDAC) are histone modifiers that are critical to chromatin structure remodeling and the transcriptional regulation of ...
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27 Search Human Diseases - [ge] HDAC9 - MalaCards
http://www.malacards.org/search/results?query=[ge]%20HDAC9
Translate this page
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28 Trichostatin A (TSA) | ≥99%(HPLC) | Selleck | HDAC inhibitor
https://www.selleckchem.com/products/Trichostatin-A.html
Trichostatin A (TSA) is a histone deacetylase (HDAC) inhibitor with IC50 of ~1.8 nM. ... Device: e-GOLIAH|Behavioral: Usual care, Autism Spectrum Disorder ...
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29 Entry - %209850 - AUTISM - OMIM
https://www.omim.org/entry/209850
209850 - AUTISM - AUTISTIC DISORDER - AUTISM, SUSCEPTIBILITY TO, 1, INCLUDED; AUTS1, INCLUDED;; AUTISM SPECTRUM DISORDER, INCLUDED; ASD, INCLUDED.
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30 Convergence of genes and cellular pathways dysregulated in ...
https://miami.elsevierpure.com/en/publications/convergence-of-genes-and-cellular-pathways-dysregulated-in-autism
Convergence of genes and cellular pathways dysregulated in autism spectrum disorders ... as well as other genes such as SETD5, MIR137, and HDAC9.
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31 Autism Database - Search - AutDB
http://autism.mindspec.org/GeneDetail/HDAC6
› GeneDetail › HDAC6
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32 HDAC9 Polymorphism Alters Blood Gene Expression in ...
https://europepmc.org/article/pmc/pmc6186202
The histone deacetylase 9 (HDAC9) polymorphism rs2107595 is associated with an increased risk for large vessel atherosclerotic stroke ... Molecular Autism.
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33 The emerging role of epigenetics in pulmonary hypertension
https://erj.ersjournals.com/content/erj/early/2016/08/04/13993003.01714-2015.full.pdf
In line with these findings, several compounds with HDAC inhibitory ... Aberrant expression of long noncoding RNAs in autistic brain.
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34 HDAC Inhibitors for which Cancer/Autism? - Epiphany
https://www.epiphanyasd.com/2018/04/hdac-inhibitors-for-which-cancerautism.html
“In the autism model, HDAC2 is abnormally high, which makes the chromatin in the nucleus very tight, preventing genetic material from accessing ...
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35 The histone deacetylase 9 gene encodes multiple protein isoforms ...
https://www.uniprot.org/citations/12590135
We have now fully characterized a new member of the Class II HDAC family, HDAC9. The enzyme contains a conserved deacetylase domain, represses reporter ...
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36 Nuclear receptor corepressors in intellectual disability ... - Gale
https://go.gale.com/ps/i.do?id=GALE%7CA636481401&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=13594184&p=AONE&sw=w
Autism spectrum disorder (ASD) is characterized by neurocognitive ... Class IIa HDACs (HDAC4, HDAC5, HDAC7, and HDAC9) are also associated with the NCOR ...
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37 HDAC inhibition imparts beneficial transgenerational effects in ...
https://www.pnas.org/doi/10.1073/pnas.1415195112
SignificanceWe demonstrate that histone deacetylase (HDAC) ... in genes encoding histone demethylase enzymes have been identified in autism, ...
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38 Convergence of Genes and Cellular Pathways ... - Columbia CEER
https://braingenethics.cumc.columbia.edu/convergence-of-genes-and-cellular-pathways-dysregulated-in-autism-spectrum-disorders/
Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders ... as well as other genes such as SETD5, MIR137, and HDAC9.
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39 Genome-wide disruption of 5-hydroxymethylcytosine in a ...
https://academic.oup.com/hmg/article/24/24/7121/2384876
The autism spectrum disorders (ASD) comprise a broad group of behaviorally ... to function in epigenetic pathways, including Tet3, Dnmt3a, Hdac7 and Hdac9.
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40 Genome-wide prediction of autism-associated genes - ASD
https://asd.princeton.edu/contexts/integration/prediction/3?gene=HDAC9
HDAC9, histone deacetylase 9, Entrez:9734 HGNC: 14065 Ensembl: ENSG00000048052 HPRD: 05944 ... HDAC9, HDAC9, histone deacetylase 9 ...
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41 Convergence of Genes and Cellular Pathways Dysregulated in ...
https://scholarship.miami.edu/esploro/outputs/journalArticle/Convergence-of-Genes-and-Cellular-Pathways-Dysregulated-in-Autism-Spectrum-Disorders/991031560959702976
Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders ... as well as other genes such as SETD5, MIR137, and HDAC9.
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42 Autism and Nonsense Mediated Decay (NMD)
https://www.itmedicalteam.pl/articles/autism-and-nonsense-mediated-decay-nmd-107357.html
... UPF3b which was associated with neurodevelopmental disorders, eIF4e in autism [15], DISC1 and HDAC9 with schizophrenia (Matsuzaki and Tohyama, 2007).
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43 Convergence of genes and cellular ... - Experts@Minnesota
https://experts.umn.edu/en/publications/convergence-of-genes-and-cellular-pathways-dysregulated-in-autism
... as well as other genes such as SETD5, MIR137, and HDAC9. ... The authors thank the main funders of the Autism Genome Project: Autism ...
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44 HDAC1 Gene - Histone Deacetylase 1 - GeneCards
https://www.genecards.org/cgi-bin/carddisp.pl?gene=HDAC1
Part of the core histone deacetylase (HDAC) complex composed of HDAC1, ... Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome ...
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45 Regulation of Central Nervous System Development by Class ...
https://www.karger.com/Article/Fulltext/505535
Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition. Nat Neurosci. 2018 Apr;21(4):564–75. External ...
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46 WO2018200608A1 - Nrf and hif activators/hdac inhibitors and ...
https://patents.google.com/patent/WO2018200608A1/en
Methods of treating diseases and conditions wherein inhibition of HDAC and/or ... autism, autism spectrum disorders, and inflammation, also are disclosed.
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47 Missense Variants in the Histone Acetyltransferase Complex ...
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02181523/document
TRRAP cause autism and syndromic intellectual disability. ... HDAC6, and HDAC9 and non-syndromic ASD and/or schizophrenia34,47–50.
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48 Association of genes with phenotype in ... - Semantic Scholar
https://pdfs.semanticscholar.org/da73/c07054314605178a337d994a41c6124c86b0.pdf
Autism spectrum disorder (ASD) is a genetic heterogeneous neurodevelopmental disorder that ... [24–26], HDAC4, and GDI1, SETD5, HDAC9, and.
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49 Link between obsessive-compulsive disorder and ...
https://cdn.publisher.gn1.link/bjp.org.br/pdf/v44n2a08.pdf
Twenty-seven single nucleotide polymorphism (SNPs) in six HDAC genes were scanned with the ... psychotic disorder, autism spectrum disorders, bipolar.
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50 Enzymes Protect the Skin by Ignoring Microbes and Viruses
https://health.ucsd.edu/news/releases/Pages/2021-05-21-superficial-relationship-enzymes-protect-the-skin-by-ignoring-microbes-and-viruses.aspx
But in skin cells, the two identified HDAC enzymes, HDAC8 and HDAC9, inhibit the inflammatory response. “This is one of the first ...
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51 GSN Publications 2015
https://www.gsn.uni-muenchen.de/about_us/publications/2015/index.html
... Haffner C and Dichgans M. (2015) Deficiency of the stroke relevant HDAC9 gene ... (2015) Genome Wide Variant Analysis of Simplex Autism Families with an ...
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52 Anti-HDAC4 antibody [HDAC-144] (ab12171) - Abcam
https://www.abcam.com/hdac4-antibody-hdac-144-ab12171.html
Knockout Tested Mouse monoclonal HDAC4 antibody [HDAC-144]. Validated in WB and tested in Mouse, Rat, Human. Cited in 7 publication(s).
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53 autism spectrum disorder Gene Set
https://maayanlab.cloud/Harmonizome/gene_set/autism+spectrum+disorder/DISEASES+Text-mining+Gene-Disease+Assocation+Evidence+Scores
autism spectrum disorder Gene Set ... 995 genes co-occuring with the disease autism spectrum disorder in ... HDAC9, histone deacetylase 9, 0.161331.
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54 Endophenotype-Wide Association Study Reveals Genetic ...
https://assets.researchsquare.com/files/rs-948337/v1_covered.pdf?c=1634050532/
Autism, endophenotype, core symptoms, cognitive function, ADOS, ADI-R ... Autism spectrum disorder (ASD) is a genetic neurodevelopmental ...
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55 Sex-specific Behavioral Features of Rodent Models of Autism ...
https://www.en-journal.org/journal/view.html?uid=421
Keywords: Sex difference, Autism spectrum disorder, Animal model, ... Changes in the expression of genes such as MAP3K11 , HDAC9 , and ...
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56 Vorinostat (SAHA) | HDAC Inhibitor - MedChemExpress
https://www.medchemexpress.com/Vorinostat.html
Customer Review ; NCT04324099, University Hospital, Basel, Switzerland|Swiss National Science Foundation. Autism-Spectrum Disorder|Conduct Disorder ; NCT01339871 ...
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57 HDAC5+16p.pdf
https://www.acsu.buffalo.edu/~zhenyan/HDAC5+16p.pdf
neurons from patients with the autism-linked 7q11.23 duplication revealed that three HDAC inhibitors normalized the expression of a.
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58 SNP rs11984041 - SelfDecode
https://selfdecode.com/app/snp/rs11984041/
[PMID 23449258] Evidence HDAC9 Genetic Variant Associated With Ischemic Stroke Increases Risk via Promoting Carotid Atherosclerosis.
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59 Alkermes Investor Day
https://investor.alkermes.com/static-files/33f8cb48-ccbd-43ee-983f-4b4957b224d9
Selective HDAC Inhibitors — Markus Haeberlein, Ph.D., Senior Vice President, Research ... o Includes certain autism spectrum disorders with.
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60 Histone deacetylases (HDACs) and brain function
https://cyberleninka.org/article/n/197913.pdf
dependent HDAC family members are composed of class I (HDACs 1, ... tients has recently linked the class IIa HDAC9 to increased risk of autism.
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61 Brasil - Link between obsessive-compulsive disorder ... - SciELO
https://www.scielo.br/j/rbp/a/cHpvMgFQfQQCxtjsCzGL8sq/?format=html&lang=en
Twenty-seven single nucleotide polymorphism (SNPs) in six HDAC genes were scanned ... autism spectrum disorders, bipolar disorder, intellectual disability, ...
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62 Next Generation Sequencing of autism genes in the Lebanese ...
https://openmindslebanon.org/sites/default/files/Jihane%20poster%20RD%202018%20autism%20final.pdf
Only a fraction of autism genes have been discovered world-wide. Applying whole exome sequencing (WES) to Lebanese families in order to identify mutations is ...
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63 MEF2C and HDAC9 - Wiki-CORONA - Madhavi Ganapathiraju
https://hagrid.dbmi.pitt.edu/corona/index.php/pair/view/4208/9734
MEF2C and HDAC9 ... anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, ...
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64 HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 ... - CNR
http://www.inmm.cnr.it/tirone/pdfs/Micheli_et_al-2017-J_Cell_Physiol%20PC3-HDACs.pdf
Overexpression of HDAC1, HDAC4, or HDAC9 in fibroblasts and in cerebellar ... Ankrd11 is a chromatin regulator involved in autism that is essential for ...
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65 Mtr | Mus musculus gene - Alliance of Genome Resources
https://www.alliancegenome.org/gene/MGI:894292
... IgA glomerulonephritis; autistic disorder; hematologic cancer (multiple); hyperhomocysteinemia; and methylmalonic aciduria and homocystinuria type cblG.
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66 Gene expression profiling differentiates autism case-controls ...
https://wp.nyu.edu/marasteinberglowe/wp-content/uploads/sites/883/2015/12/Hu-et-al-2009_Gene-Expression-Profiling-Differentiates-Autism-Case-Controls-and-Phenotypic-Variants-of-ASD.pdf
Keywords: autism phenotypes; gene expression profiling; circadian rhythm; novel genes. Introduction. Autism spectrum disorders (ASD) collectively refer to a.
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67 The histone deacetylase complex MiDAC regulates a ... - eLife
https://elifesciences.org/articles/57519
While other HDAC complexes have been implicated in neurogenesis, ... noncoding mutations in several MiDAC components among autism patients, ...
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68 Convergence of Genes and Cellular Pathways ... - scanR
https://scanr.enseignementsup-recherche.gouv.fr/publication/doi10.1016%25252fj.ajhg.2014.03.018
Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum ... as well as other genes such as SETD5, MIR137, and HDAC9.
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69 Convergence of Genes and Cellular Pathways Dysregulated ...
https://www.hal.inserm.fr/inserm-00986225
... as well as other genes such as SETD5, MIR137, and HDAC9. ... Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders.
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70 College of Allied Health Sciences - Scholarly Commons
https://augusta.openrepository.com/handle/10675.2/78
Only 58% of children who meet the criteria for a diagnosis of autism spectrum ... Here, we hypothesized that adipose HDAC9 correlate with human obesity ...
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71 Pregnant Women Should Avoid Paracetamol Which Is Linked ...
https://www.thailandmedical.news/news/pregnant-women-should-avoid-paracetamol-which-is-linked-to-adhd-and-autism-
... may be linked to an increased risk of childhood attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD).
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72 Development Of Novel Radiotracers For Pet Imaging Of Hdac ...
https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=2518&context=oa_dissertations
... HDAC Class IIa enzymes in the brain and their involvement with Alzheimer's, stress related disorders, Autism and addiction (Volmar and.
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73 RELATED GENES
https://repositorio-aberto.up.pt/bitstream/10216/107262/2/211861.pdf
Autism spectrum disorder (ASD) is characterized by persistent deficits in ... removed by histone deacetylases (HDAC), DNA methylation (Me) by DNA ...
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74 How MC4R, FTO, PPARG can sabotage Self-Esteem
https://www.potomacpsychiatry.com/blog/dna-emotional-health-fkbp5-pcsk9-smarca4-genes
Unhealthy eating habits and sedentary lifestyles can leave us prone to dyslipidemia and atherosclerosis—but so can our genes… in particular, our HDAC9, ...
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75 Convergence of genes and cellular pathways dysregulated in ...
https://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/year/2014/docId/35397
... variation (CNV) is an important source of risk for autism spectrum disorders (ASDs). ... as well as other genes such as SETD5, MIR137, and HDAC9.
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76 The SCFA butyrate stimulates the epithelial production of ...
https://journals.physiology.org/doi/full/10.1152/ajpgi.00411.2015
Besides its role as a major energy source for intestinal epithelial cells, butyrate affects other cellular processes, including the inhibition of HDAC enzymes ( ...
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77 Autism pathways
http://www.polygenicpathways.co.uk/autismkegg.htm
These maps, etched out by numerous Autism susceptibility gene candidates from the Autism gene database from Mindspec, literature survey and GWAS studies ...
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78 selective hdac inhibitors: Topics by Science.gov
https://www.science.gov/topicpages/s/selective+hdac+inhibitors.html
Histone deacetylase (HDAC) enzymes have emerged as promising targets for the treatment of a ... loss of memory, neurodegeneration and autistic disorders.
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79 Opening a New Time Window for Treatment of Stroke by ...
https://www.jneurosci.org/content/37/28/6712
In this window phase, suppressing HDAC2 in the peri-infarct cortex of rodents by HDAC inhibitors, knockdown or knock-out of Hdac2 promoted ...
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80 Investigação funcional do novo locus candidato, HDAC9 ...
https://www.teses.usp.br/teses/disponiveis/41/41131/tde-25052021-091729/publico/Sofia_Ramos.pdf
Investigação funcional de locus candidato, HDAC9, causativo da Síndrome aurículo-condilar ... autism spectrum disorders. Autism Research, v.
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81 MACROCEPHALY/AUTISM SYNDROME | MENDELIAN.CO
https://www.mendelian.co/diseases/macrocephaly-autism-syndrome
MACROCEPHALY/AUTISM SYNDROME description, symptoms and related genes. Get the complete information in our medical search engine for phenotype-genotype.
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82 The Genetic and Epigenetic Basis Involved in ... - IntechOpen
https://www.intechopen.com/chapters/53617
The prevalence of autism has increased in an exponential way in the past few years. ... such as histone deacetylases (HDAC) and other chromatin remodeling ...
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83 Valproic Acid Attenuates Blood–Brain Barrier Disruption in a ...
https://journals.sagepub.com/doi/10.1038/jcbfm.2010.195
Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, is known to protect against cerebral ischemia. The effects of VPA on blood–brain barrier (BBB) ...
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84 MEF-2 isoforms' (A-D) roles in development and tumorigenesis
https://www.oncotarget.com/article/26763/text/
Overexpression of HDAC9 has been linked to poor prognosis of oral ... in development of autism, schizophrenia, and epilepsy [10, 202–204].
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85 Missense Variants in the Histone Acetyltransferase Complex ...
https://discovery.dundee.ac.uk/ws/files/41258939/1_s2.0_S0002929719300102_main.pdf
The second spectrum manifested with autism spectrum dis- ... Shen, S. (2011). HDAC9 is implicated in schizophrenia and ex-.
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86 Butyrate Histone Deacetylase Inhibitors - Mary Ann Liebert, Inc.
https://www.liebertpub.com/doi/10.1089/biores.2012.0223
1) became the first HDAC inhibitor to be clinically approved by the Food and Drug Administration for use in the treatment of cutaneous T-cell ...
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87 Link between obsessive-compulsive disorder and polymorphisms in ...
https://www.bjp.org.br/details/2204/en-US/link-between-obsessive-compulsive-disorder-and-polymorphisms-in-hdac-genes
Twenty-seven single nucleotide polymorphism (SNPs) in six HDAC genes were scanned ... autism spectrum disorders, bipolar disorder, intellectual disability, ...
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88 The discovery of integrated gene networks for autism and ...
http://borensteinlab.com/pub/gennet_hormozdiari_gr.pdf
of genes affected by CNVs in autism (Gilman et al. 2011) and ... occur in six genes in M1 (TCF4, SUPT16H, CASK, GPS1, HDAC9,.
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89 brain-region-specific contributions of foxp1 to autism and
https://utswmed-ir.tdl.org/bitstream/handle/2152.5/7209/ARAUJO-DISSERTATION-2017.pdf?sequence=1&isAllowed=y
forms of autism spectrum disorder (ASD) that are often comorbid with ... Hdac9. INO80D. CABLES1. Ccdc151. Hif3a. INPP5A. CACNA1A. Ccdc153.
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90 CRISPR reduces autism symptoms in mice - UC Berkeley News
https://news.berkeley.edu/2018/06/25/crispr-reduces-autism-symptoms-in-mice/
Scientists have used CRISPR-Cas9 gene editing to lessen some autism symptoms in mice with a form of fragile X syndrome, the most common known ...
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91 Histone acetylation and deacetylation - Wikipedia
https://en.wikipedia.org/wiki/Histone_acetylation_and_deacetylation
Thus, acetylation of histones is known to increase the expression of genes through transcription activation. Deacetylation performed by HDAC molecules has the ...
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92 Largest study yet identifies over 200 genes strongly linked to ...
https://thehill.com/changing-america/well-being/prevention-cures/3607873-largest-study-identifies-over-200-genes-strongly-linked-to-autism/
“Some individuals with autism spectrum disorder carry functional mutations rarely observed in the general population,” researchers explained. To ...
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93 Researchers discover HDAC1 as the cause of immune ...
https://globalseopulse.com/researchers-discover-hdac1-as-the-cause-of-immune-abnormalities-in-autistic-mouse-models/
Recent contributions in genetic research have identified autism rescue genes, of which ... Regulation of HDAC activity during the fetal stage ameliorated ...
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