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1 The Latest in Animal Models of Pulmonary Hypertension and ...
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.319971
Although often used to draw conclusions in group 1 PH, exposure to animals to chronic hypoxia is largely considered as a model recapitulating ...
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2 the evolution of animal models in pulmonary hypertension ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070827/
Animals with pulmonary hypertension show a pattern consistent with decreased pulmonary artery acceleration time (PAAT) with or without midsystolic notching ( ...
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3 Animal models of pulmonary hypertension: Getting to the heart ...
https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15444
Several small animal models are used in the study of PH, including the classic models of exposure to either hypoxia or monocrotaline, newer ...
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4 Animal models of pulmonary arterial hypertension
https://journals.physiology.org/doi/10.1152/ajplung.00217.2009
The most commonly used animal models of PH are the chronic hypoxic model and the monocrotaline injury model. These animal models have been used for quite some ...
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5 Animal models of pulmonary hypertension - ScienceDirect.com
https://www.sciencedirect.com/science/article/pii/S1740675711000041
The monocrotaline model is a, if not the, classical model for pulmonary hypertension (PH) and widely used as such. The preferred species for the study of ...
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6 Animal Models with Pulmonary Hypertension | SpringerLink
https://link.springer.com/chapter/10.1007/978-981-287-840-3_7
3 Other Animal Models with Pulmonary Hypertension · 3.1 Fawn-Hooded Rats · 3.2 Mice Overexpressing S100A4/Mts1 · 3.3 Mice Overexpressing IL-6 · 3.4 ...
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7 Mouse model of experimental pulmonary hypertension: Lung ...
https://journals.sagepub.com/doi/full/10.1177/20458940211041512
Chronically hypoxic mice exhibit significant increases in pulmonary artery (PA) pressure with minimal vascular remodeling compared to rats. ... The most common ...
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8 Altered TGFβ/SMAD Signaling in Human and Rat Models of ...
https://www.mdpi.com/2073-4409/10/1/84
Pulmonary arterial hypertension (PAH) is a fatal disease characterized by elevated ... In the two animal models, pulmonary vascular remodeling and right ...
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9 Animal Models for the Study of Pulmonary Hypertension
https://www.fortunejournals.com/articles/panimal-models-for-the-study-of-pulmonary-hypertension-potential-and-limitationsp.html
The chronic hypoxia model is one of the most used to study PH pathogenesis and treatment. Its pathological features of pulmonary vasoconstriction and vascular ...
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10 A Novel Murine Model of Severe Pulmonary Arterial ...
https://www.atsjournals.org/doi/10.1164/rccm.201103-0412OC
Mice developed severe pulmonary hypertension and vascular remodeling characterized by smooth muscle cell neointima and precapillary EC ...
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11 A Process-Based Review of Mouse Models of Pulmonary ...
https://pvrinstitute.org/en/pc-journal/explore-the-journal/pulmonary-circulation-vol-2-no-4/a-process-based-review-of-mouse-models-of-pulmonary-hypertension/
Genetically modified mouse models have unparalleled power to determine the mechanisms behind different processes involved in the molecular and physiologic ...
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12 Experimental animal models of pulmonary hypertension
https://search.proquest.com/openview/dca76fe4ecfe91c6ecfeb6792ad8af87/1?pq-origsite=gscholar&cbl=4365297
The chronic hypoxia-induced PH (CHPH) animal model is a classic experimental PH model with good predictability and repeatability. ... Preclinical models of CHPH ...
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13 What Animal Models Tell Us about Treatments for Pulmonary ...
https://ebooks.iospress.nl/volumearticle/23153
Animal models of pulmonary hypertension are used to evaluate new therapies, both their efficacy and the mechanism of their effect.
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14 (R)-Crizotinib Predisposes To and Exacerbates Pulmonary ...
https://erj.ersjournals.com/content/early/2021/01/08/13993003.03271-2020
(R)-Crizotinib Predisposes To and Exacerbates Pulmonary Arterial Hypertension in Animal Models ; Charifa Awada ; Yann Grobs ; Wen-Hui Wu ; Karima Habbout ; Charlotte ...
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15 A Large Animal Model of Right Ventricular Failure due to ...
https://www.frontiersin.org/articles/10.3389/fcvm.2018.00189/full
Chronic thromboembolic pulmonary hypertension (CTEPH) is a debilitating disease that progresses to right ventricular (RV) failure and death if ...
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16 Reversal of MicroRNA Dysregulation in an Animal Model of ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147827
Animals models have played an important role in enhancing our understanding of the pathogenesis of pulmonary arterial hypertension (PAH).
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17 Animal models of pulmonary hypertension: Rho kinase ...
https://www.cirm.ca.gov/printpdf/about-cirm/publications/animal-models-pulmonary-hypertension-rho-kinase-inhibition
Animal models of pulmonary hypertension: Rho kinase inhibition. ... common is that termed pulmonary arterial hypertension or PAH; a rare but often fatal ...
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18 Animal models of right heart failure - Andersen
https://cdt.amegroups.com/article/view/44665/html
Keywords: Pulmonary hypertension (PH); animal models; pulmonary heart disease; congenital heart defects; pulmonary embolism (PE) ...
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19 The Sugen 5416/Hypoxia Mouse Model of Pulmonary Arterial ...
https://experiments.springernature.com/articles/10.1007/978-1-4939-8597-5_19
PAH pathobiology involves a remodeling process in pulmonary arteries that plays a critical role in elevating pulmonary arterial and right ventricle pressures.
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20 Mouse Model Developed to Study Right Ventricular Recovery ...
https://med.stanford.edu/cvi/mission/news_center/articles_announcements/mouse-model-developed-to-study-right-ventricular-recovery-in-pul.html
To study the capability of the RV to adapt to an increased, animal models mimicking right ventricular afterload have been developed. One method ...
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21 The Latest in Animal Models of Pulmonary ... - ResearchGate
https://www.researchgate.net/publication/360262201_The_Latest_in_Animal_Models_of_Pulmonary_Hypertension_and_Right_Ventricular_Failure
... Animal models do not fully reproduce the features of human PAH, which is a key obstacle to drug development 8, 9 . Organs-onchips have ...
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22 Animal Models of Human Severe PAH - Allen Press
https://meridian.allenpress.com/aph/article/7/3/346/432098/Animal-Models-of-Human-Severe-PAH
Pulmonary arterial hypertension (PAH) · PH with left-sided heart disease · PH associated with respiratory disorders and/or hypoxemia · PH caused by ...
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23 Challenges in the development of chronic pulmonary ...
https://vascularbiosciences.com/wp-content/uploads/2013/10/Challenges-in-the-development-of-chronic-pulmonary-hypertension-models-in-large-animals-1.pdf
Pulmonary hypertension (PH) results in significant morbidity and mortality. Chronic PH animal models may advance the study of.
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24 Chronic hypoxia aggravates monocrotaline-induced ...
https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-017-0533-x
Pulmonary arterial hypertension (PAH) is a severe form of ... Multiple-pathological-insult animal models, developed to more closely mimic ...
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25 [Animal models of pulmonary arterial hypertension]. - Abstract
https://europepmc.org/article/med/17468705
BACKGROUND:Experimental animal models of PAH rely on hypoxic or monocrotaline injected rodents, the creation of left to right shunts in lambs or piglets, ...
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26 Introduction to animal models of pulmonary hypertension
https://pesquisa.bvsalud.org/portal/resource/pt/wpr-789066
Animal models of PAH act as effective methods to study the pathogenesis,pathophysiology,development,prognosis and treatment of PAH.Classic PAH models include ...
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27 Animal Models of Pulmonary Hypertension
https://jabps.journals.ekb.eg/article_257919_86dcc87fbf96ebb07b0a387b4b901266.pdf
Pulmonary hypertension (PH) is a life threatening pulmonary vascular disease, characterized by elevated pulmonary arterial pressure.
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28 Large Animal Studies in Pulmonary Hypertension-What ...
https://www.journalofsurgicalresearch.com/article/S0022-4804(11)00606-8/pdf
Pulmonary arterial hypertension (PAH) is a devastating cardiopulmonary disease characterized by vasoconstriction and progressive remodeling ...
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29 evidence from animal models to man - Scholars@UAB
https://scholars.uab.edu/display/pub2317463
Pulmonary vascular remodeling in pulmonary hypertension: evidence from animal models to man. Chapter. Overview; Identity ...
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30 A new animal model for pulmonary hypertension based on the ...
https://www.annalsthoracicsurgery.org/article/S0003-4975(03)01350-X/fulltext
Overexpression of angiopoietin-1 using an adeno-associated virus vector causes pulmonary hypertension in rats. These data provide a novel physiologic animal ...
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31 Characterization and Development of a New Animal Model of ...
https://www.sbir.gov/content/characterization-and-development-new-animal-model-pulmonary-hypertension-0
At the present time, a major obstacle facing basic pulmonary hypertension (PH) and right ventricular (RV) dysfunction/failure research is the lack of good, ...
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32 Bone marrow transplantation prevents right ventricle disease ...
https://ashpublications.org/bloodadvances/article/1/9/526/15607/Bone-marrow-transplantation-prevents-right
... in the caveolin-1–deficient mouse model of pulmonary hypertension ... animal models further support the essential role for CAV-1 in PH.
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33 [PDF] Animal models of pulmonary arterial hypertension
https://www.semanticscholar.org/paper/Animal-models-of-pulmonary-arterial-hypertension%3A-Stenmark-Meyrick/699aafb1ee57e4419389ecfd8cf99363ba7923f3
Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure. · K. Stenmark, B. Meyrick, +2 ...
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34 Mechanisms of disease: pulmonary arterial hypertension
https://www.nature.com/articles/nrcardio.2011.87
Notably, although the existing animal models inform on certain aspects of PAH, no animal model of pulmonary hypertension recapitulates the human ...
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35 Plexiform Arteriopathy in Rodent Models of Pulmonary Arterial ...
https://ajp.amjpathol.org/article/S0002-9440(18)31156-8/fulltext
Much of the advancements that aid in understanding disease mechanics are based on animal studies. Unfortunately, animal models often fail to ...
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36 Hypoxia-inducible factor signaling in pulmonary hypertension
https://www.jci.org/articles/view/137558
Furthermore, PPARα agonist–mediated transcription of miR-199a2 attenuates ET-1 expression and HIF-1α level, ameliorating PH in a mouse model of SCD (48–50).
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37 Development and Characterization of an Animal Model of ...
https://www.karger.com/Article/Fulltext/329594
Pulmonary arterial hypertension (PAH) is a serious pathological phenomenon with poor prognosis, which is associated with morphological as ...
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38 Large Animal Model of Chronic Pulmonary Hypertension
https://journals.lww.com/asaiojournal/Fulltext/2008/07000/Large_Animal_Model_of_Chronic_Pulmonary.10.aspx
A large animal model is needed to study artificial lung attachment in a setting simulating chronic lung disease with significant pulmonary hypertension (PH) ...
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39 Macitentan treatment retards the progression of established ...
https://www.internationaljournalofcardiology.com/article/S0167-5273(14)01707-0/abstract
... of established pulmonary arterial hypertension in an animal model ... Treatment of established pulmonary hypertension with macitentan ...
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40 Comparison of hypoxia-induced pulmonary hypertension rat ...
https://www.tandfonline.com/doi/full/10.1080/01902148.2022.2148016?src=
The hypoxia-induced pulmonary hypertension (HPH) rat model is commonly used in this field. While the HPH rat model has strong predictability ...
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41 Animal Models of Pulmonary Hypertension: Matching Disease ...
https://www.hilarispublisher.com/open-access/animal-models-of-pulmonary-hypertension-matching-disease-mechanisms-to-etiology-of-the-human-disease-2161-105X.1000198.pdf
Animal Models of Pulmonary Hypertension: Matching Disease Mechanisms to. Etiology of the Human Disease. Kelley L. Colvin1,2,3,4 and Michael ...
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42 Rat Model of Pulmonary Arterial Hypertension” in volume 48 ...
https://e-kcj.org/DOIx.php?id=10.4070/kcj.2017.0394
Macitentan; Pulmonary hypertension; Hemodynamics; Pathology ... Although no animal model fully reflects the pathophysiology of human PAH, ...
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43 Reactive Oxygen Species Signaling in Animal Models of ...
https://www.taylorfrancis.com/chapters/edit/10.1201/9780367494018-18/reactive-oxygen-species-signaling-animal-models-pulmonary-hypertension-stephen-wedgwood-satyan-lakshminrusimha-robin-steinhorn
Persistent pulmonary hypertension of the newborn (PPHN) occurs when the pulmonary circulation fails to adapt to postnatal life. PPHN.
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44 Animal Models of Pulmonary Hypertension - OUCI
https://ouci.dntb.gov.ua/en/works/7qOwwmwl/
Stenmark KR, Meyrick B, Galie N, Mooi WJ, McMurtry IF. Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological ...
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45 Inflammatory Basis of Pulmonary Arterial Hypertension
https://pubs.asahq.org/anesthesiology/article/131/4/898/921/Inflammatory-Basis-of-Pulmonary-Arterial
The Fifth World Symposium on Pulmonary Hypertension proposed a ... of elafin in animal models reverses pulmonary arterial hypertension.64 As such, ...
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46 TNF Receptor 1 May Drive Pulmonary Arterial Hypertension ...
https://www.medpagetoday.com/meetingcoverage/acrvideopearls/101851
... for TNF-mediated pulmonary endothelial and stromal pathology that causes pulmonary arterial hypertension (PAH), in a mouse model of ...
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47 Canine pulmonary hypertension assessment with ultrasound
https://www.animalultrasoundassociation.org/canine-pulmonary-hypertension-assessment-ultrasound/
Pulmonary hypertension frequently accompanies respiratory disorders, heartworm disease and chronic degenerative mitral valve disease in dogs (Tai and Huang, ...
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48 Pulmonary Hypertension: The Present and Future
https://books.google.com/books?id=YBwco7qgj-4C&pg=PA163&lpg=PA163&dq=animal+models+pulmonary+hypertension&source=bl&ots=89dfeA1E7o&sig=ACfU3U3Abcvv8VYz7nVXMviSSIMESTzxAw&hl=en&sa=X&ved=2ahUKEwjtxtO4ytj7AhVgl3IEHRxIAtAQ6AF6BQjXAhAD
... and interventions in the MCT Rat Model of Pulmonary Hypertension Granulocyte ... Unfortunately , and surprisingly , all efforts , using different animal ...
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49 Types of Pulmonary Hypertension: The WHO Groups
https://phassociation.org/types-pulmonary-hypertension-groups/
Not all pulmonary hypertension (PH) is the same. PH is a general term used to describe high blood pressure in the lungs from any cause.
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50 New target in the fight against heart disease - Jagwire – Augusta
https://jagwire.augusta.edu/new-target-in-the-fight-against-heart-disease/
“Our model demonstrates that this ATIC is important and targetable,” says Ma. ... pathways for purine production in pulmonary hypertension, ...
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51 How to lower your heart rate: 11 ways - Medical News Today
https://www.medicalnewstoday.com/articles/321310
Preclinical animal studies have shown that stem cell therapy could potentially help to treat pulmonary hypertension and PAH.
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52 Pulmonary hypertension: Presentation, Diagnosis ... - YouTube
https://www.youtube.com/watch?v=5FkwmDeWQNE
The causes of pulmonary hypertension in dogs are many, ... Animal Emergency & Referral Center of Minnesota (AERC) locations: OAKDALE 1163 ...
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53 Scientists report new target to combat coronary artery disease
https://www.news-medical.net/news/20221129/Scientists-report-new-target-to-combat-coronary-artery-disease.aspx
"Our model demonstrates that this ATIC is important and targetable," says Ma. ... pathways for purine production in pulmonary hypertension, ...
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54 New target in the fight against heart disease - ScienceDaily
https://www.sciencedaily.com/releases/2022/11/221129112851.htm
"Our model demonstrates that this ATIC is important and targetable," says Ma. ... pathways for purine production in pulmonary hypertension, ...
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55 Preclinical Mouse Models of Pulmonary Disease: Acute Lung ...
https://www.biomodels.com/webinars/preclinical-mouse-models-of-pulmonary-disease-acute-lung-injury-acute-severe-asthma
Preclinical Mouse Models of Pulmonary Disease: Acute Lung Injury, Acute & Severe Asthma, & Pulmonary Fibrosis ... Overview: Pulmonary disease is the third leading ...
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56 Lung Disease News
https://lungdiseasenews.com/
Home · News · COPD · Lung Cancer · Asthma · Cystic Fibrosis · Pulmonary Hypertension · Idiopathic Pulmonary Fibrosis · Bronchiectasis · About Lung Disease.
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57 Definition of areola - NCI Dictionary of Cancer Terms
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/areola
› cancer-terms › def › areola
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58 ClinicalKey - Lead with Answers
https://www.clinicalkey.com/

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59 Hematopoietic Stem Cell Gene Therapy May Be Beneficial in ...
https://www.rarediseaseadvisor.com/news/pompe-news-briefs/hematopoietic-stem-cell-gene-therapy-may-be-beneficial-in-pd-management/
HSPC gene therapy may lead to increased GAA levels in animal models, showing its therapeutic potential in PD, a study found.
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60 New target in the fight against heart disease - EurekAlert
https://www.eurekalert.org/news-releases/972557
... of scar tissue in animal models of both atherosclerosis and restenosis, ... pathways for purine production in pulmonary hypertension, ...
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61 Blood pressure - Wikipedia
https://en.wikipedia.org/wiki/Blood_pressure
In animalsEdit · Blood pressure levels in non-human mammals may vary depending on the species. · Hypertension in cats and dogs is generally diagnosed if the blood ...
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62 Ana Sarkar (@AnaSarkar3) / Twitter
https://twitter.com/anasarkar3
to study RNA signaling in pulmonary hypertension. ... In order to develop safe and effective vaccines, suitable animal models must be established.
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63 Pulmonology Program Led by Tampa General Hospital and ...
https://www.prnewswire.com/news-releases/pulmonology-program-led-by-tampa-general-hospital-and-usf-health-joins-two-global-organizations-with-a-shared-purpose-to-empower-patients-301689219.html
The USF Health and Tampa General Hospital pulmonary and critical care ... lung disease, pulmonary hypertension, and pulmonary infections.
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64 Health Topics - CDC
https://www.cdc.gov/health-topics.html
by H Living · Cited by 10 —
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65 New goal in fight against heart disease | Mirage News
https://www.miragenews.com/new-goal-in-fight-against-heart-disease-904929/
... of scar tissue in animal models of both atherosclerosis and restenosis, ... pathways for purine production in pulmonary hypertension, ...
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66 TrueQuant SmallRNA Seq Kit- Ultra Low Input Single Tube
https://genxpro.net/truequant-smallrna-seq-kit/
TrueQuant SmallRNA Seq Kit for Ultra Low Input, GEL FREE, Single Tube Protocol · Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using ...
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67 LITFL • Life in the Fast Lane
https://litfl.com/

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68 Columns - Nanotechnology Now
https://www.nanotech-now.com/columns/
... billion generated last year alone from this new investment model (1)(2). ... status asthmaticus, pulmonary hypertension, lung cancer and complications ...
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69 New Genetic Cause of Pulmonary Hypertension Identified
https://www.cuimc.columbia.edu/news/new-genetic-cause-pulmonary-hypertension-identified
Cell culture studies showed that the mutations' effects could be reversed with a drug compound known as a phospholipase inhibitor. The study was ...
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70 Bayer – Global Home | Bayer global
https://www.bayer.com/en/
With our distinctive knowledge of people, animals and plants, we focus on the areas of health care and nutrition. ... Pulmonary Hypertension. Rice Seed.
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71 FDA Clears Parky App, Device to Monitor Motor Symptoms
https://parkinsonsnewstoday.com/news/fda-clears-parky-app-device-monitor-parkinsons-symptoms/
From 2013, she has held a fellowship working with Pulmonary Hypertension ... Hallmarks of Parkinson's Disease in Animal Model November 29, ...
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72 Association of Prenatal Exposure to Benzodiazepines With ...
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2798872
Moreover, although few studies have examined how different trimesters ... through associations with germline epigenome in the animal model, ...
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73 Heart | Structure, Function, Diagram, Anatomy, & Facts
https://www.britannica.com/science/heart
In animals with lungs—amphibians, reptiles, birds, and mammals—the heart ... Oxygenated blood is returned to the left atrium through the pulmonary veins.
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74 Read Online Chapter 11 Cardiovascular System Pdf File Free
https://www.museumkebaharian.jakarta-tourism.go.id/data/blackhole?l=I5G3T8&FileName=Chapter_11_Cardiovascular_System
Key chapters address animal models for cardiac research, cardiac ... also features: An additional chapter on pulmonary hypertension Even ...
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75 Download Free Nutrition Therapy And Pathophysiology Free ...
https://new.alessa.bg/reader/svg?l=Y6B6L5&FileName=Nutrition%20Therapy%20And%20Pathophysiology
Luteal Phase Pulmonary Hypertension Hematology. ... The face validity, predictability and usefulness of animal models in the.
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76 Mri Protocols (PDF) - New Look Time
https://mautic.newlooktime.com.br/viewcontent?ID=75225&FileName=Mri%20Protocols.pdf
animal renal MRI in your laboratory as a ... animal models of disease and the ... pulmonary hypertension and even lung cancer. The diagnostic benefits stem ...
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77 Calendar of Scientific Events
http://calendar.duke.edu/s/Scientific
... Mandel Center for Hypertension and Atherosclerosis, Manuscript Migration Lab, Markets and Management Studies (MMS), Martin Luther King, Jr. Celebration ...
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78 Pulmonary Arterial Hypertension - NORD (National ...
https://rarediseases.org/videos/pulmonary-arterial-hypertension/
Pulmonary arterial hypertension (PAH) is a rare, progressive disorder characterized by high blood pressure (hypertension) in the arteries of the lungs ...
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79 Pulmonary Hypertension - Physiopedia
https://www.physio-pedia.com/Pulmonary_Hypertension
Advances in hemodynamic studies of the right heart side and pulmonary circulations have helped improve our understanding of this condition. This better ...
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80 Pulmonary Hypertension - Page 61 - Google Books Result
https://books.google.com/books?id=_SasCQAAQBAJ&pg=PA61&lpg=PA61&dq=animal+models+pulmonary+hypertension&source=bl&ots=usembbc3-P&sig=ACfU3U2KkYuf8_5YxB0T7U_tRp2BsU8X1Q&hl=en&sa=X&ved=2ahUKEwjtxtO4ytj7AhVgl3IEHRxIAtAQ6AF6BQjiAhAD
A realistic model of pulmonary hypertension is expected to integrate ... by remodeling has been confirmed in a variety of experimental animal models.
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81 Pulmonary Arterial Hypertension: Focusing on a Future : ...
https://books.google.com/books?id=52ySbAcTwEwC&pg=PA80&lpg=PA80&dq=animal+models+pulmonary+hypertension&source=bl&ots=KhD_l4RHJw&sig=ACfU3U2wdgUGgkHsH37UfeQhR8xiJqqT3Q&hl=en&sa=X&ved=2ahUKEwjtxtO4ytj7AhVgl3IEHRxIAtAQ6AF6BQjjAhAD
inhibitors shown to act synergistically in models of pulmonary ... The experimental evidence obtained in the animal studies compiled in sections 3-7, ...
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82 Types of PH - Pulmonary Hypertension Association of Canada
https://phacanada.ca/What-is-PH/Types-of-PH
Not all pulmonary hypertension (PH) is the same. The World Health Organization (WHO) has identified five types of PH based on affects the body and how it is ...
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83 Pulmonary Arterial Hypertension - WebMD
https://www.webmd.com/lung/pulmonary-arterial-hypertension
WebMD explains pulmonary hypertension -- its symptoms, causes, diagnosis, and treatments.
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84 Pulmonary Arterial Hypertension - CheckRare
https://checkrare.com/pulmonary-arterial-hypertension/
Pulmonary arterial hypertension (PAH) is a rare, progressive disorder characterized by high blood pressure (hypertension) in the arteries of ...
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85 Treatment of Pulmonary Hypertension - Page 61 - Google Books Result
https://books.google.com/books?id=Sg1cCgAAQBAJ&pg=PA61&lpg=PA61&dq=animal+models+pulmonary+hypertension&source=bl&ots=mHDeTPZpqQ&sig=ACfU3U1i4VmJJTSOh-kgz6rU64kIQ7AzBA&hl=en&sa=X&ved=2ahUKEwjtxtO4ytj7AhVgl3IEHRxIAtAQ6AF6BQjlAhAD
... and ameliorated established pulmonary hypertension in a chronic hypoxic rat model [164]. ... has also been investigated in animal models of PAH.
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86 Pharmacotherapy of Pulmonary Hypertension
https://books.google.com/books?id=8VonAQAAQBAJ&pg=PA263&lpg=PA263&dq=animal+models+pulmonary+hypertension&source=bl&ots=RJK3-E0cM5&sig=ACfU3U0ZsaYiB1-NWZLgUySUK8jinhprtw&hl=en&sa=X&ved=2ahUKEwjtxtO4ytj7AhVgl3IEHRxIAtAQ6AF6BQjkAhAD
Mechanisms that lead to the failure of PVR to fall at birth have been pursued in diverse animal models, including exposure to acute or chronic hypoxia after ...
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