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1
Major Clinical Trials of Hypertension - AHA Journals
https://www.ahajournals.org/doi/10.1161/01.HYP.0000168924.37091.58
The National Heart, Lung, and Blood Institute assembled an ad hoc working group to evaluate opportunities for new major clinical trials in the field of ...
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https://www.ahajournals.org/doi/10.1161/01.HYP.0000168924.37091.58
The National Heart, Lung, and Blood Institute assembled an ad hoc working group to evaluate opportunities for new major clinical trials in the field of ...
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2
Hypertension trials update | Journal of Human ... - Nature
https://www.nature.com/articles/s41371-020-00477-1
The Hygia study represents the largest study that tested night-time antihypertensive treatment. In this trial, chronotherapy was associated with ...
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https://www.nature.com/articles/s41371-020-00477-1
The Hygia study represents the largest study that tested night-time antihypertensive treatment. In this trial, chronotherapy was associated with ...
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3
Trial of Intensive Blood-Pressure Control in Older Patients with ...
https://www.nejm.org/doi/full/10.1056/NEJMoa2111437
Several large trials have shown a beneficial effect of intensive blood-pressure control on cardiovascular outcomes in older patients, but the ...
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https://www.nejm.org/doi/full/10.1056/NEJMoa2111437
Several large trials have shown a beneficial effect of intensive blood-pressure control on cardiovascular outcomes in older patients, but the ...
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4
Arterial hypertension – Clinical trials update 2021 - PMC - NCBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444354/
The trials included in this review are related to hypertension onset age and risk for future cardiovascular disease, reliability of ...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444354/
The trials included in this review are related to hypertension onset age and risk for future cardiovascular disease, reliability of ...
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5
Systolic Blood Pressure Intervention Trial - Full Text View
https://clinicaltrials.gov/ct2/show/NCT01206062
The Systolic Blood Pressure Intervention Trial (SPRINT) is a 2-arm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at ...
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https://clinicaltrials.gov/ct2/show/NCT01206062
The Systolic Blood Pressure Intervention Trial (SPRINT) is a 2-arm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at ...
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6
Cardiovascular outcomes in adults with hypertension with ...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01786-X/fulltext
and the subsequent larger study from the same research group, the Hygia Chronotherapy Trial. Hermida RC; Crespo JJ; Domínguez-Sardiña M ...
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https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01786-X/fulltext
and the subsequent larger study from the same research group, the Hygia Chronotherapy Trial. Hermida RC; Crespo JJ; Domínguez-Sardiña M ...
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7
Antihypertensive drug effects on long-term blood pressure
https://heart.bmj.com/content/108/16/1281
Methods We conducted an individual patient-level data meta-analysis of 52 large-scale randomised clinical trials in the Blood Pressure Lowering Treatment ...
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https://heart.bmj.com/content/108/16/1281
Methods We conducted an individual patient-level data meta-analysis of 52 large-scale randomised clinical trials in the Blood Pressure Lowering Treatment ...
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8
Recent hypertension trials: Implications and controversies
https://www.sciencedirect.com/science/article/pii/S0735109704024866
Updated large-scale epidemiologic studies and the meta-analysis of clinical trial data have better informed this debate and emphasized that the main driver of ...
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https://www.sciencedirect.com/science/article/pii/S0735109704024866
Updated large-scale epidemiologic studies and the meta-analysis of clinical trial data have better informed this debate and emphasized that the main driver of ...
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9
Fewer Mega-Trials and More Clinically Oriented Studies in ...
https://jasn.asnjournals.org/content/17/4_suppl_2/S36
In interpreting the results of a mega-trial in hypertension and transferring the conclusions to daily practice, it must be considered that the potential benefit ...
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https://jasn.asnjournals.org/content/17/4_suppl_2/S36
In interpreting the results of a mega-trial in hypertension and transferring the conclusions to daily practice, it must be considered that the potential benefit ...
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10
Large multicentre hypertension trials - Lippincott
https://journals.lww.com/co-nephrolhypertens/fulltext/2000/05000/large_multicentre_hypertension_trials.13.aspx
The earlier large multicentre trials in hypertensive patients addressed questions of whether mild to moderate hypertension should be treated and whether ...
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https://journals.lww.com/co-nephrolhypertens/fulltext/2000/05000/large_multicentre_hypertension_trials.13.aspx
The earlier large multicentre trials in hypertensive patients addressed questions of whether mild to moderate hypertension should be treated and whether ...
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11
Fixed Low-Dose Triple Combination Antihypertensive ...
https://jamanetwork.com/journals/jama/fullarticle/2697010
Recent trials of triple therapy have demonstrated benefits among patients with severe hypertension not controlled by dual therapy, and ...
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https://jamanetwork.com/journals/jama/fullarticle/2697010
Recent trials of triple therapy have demonstrated benefits among patients with severe hypertension not controlled by dual therapy, and ...
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12
Dementia and Disability Outcomes in Large Hypertension ...
https://academic.oup.com/aje/article/153/1/72/107808
In the Systolic Hypertension in the Elderly Program (SHEP) trial (1985–1990), active treatment reduced the incidence of cardiovascular events, but not that of ...
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https://academic.oup.com/aje/article/153/1/72/107808
In the Systolic Hypertension in the Elderly Program (SHEP) trial (1985–1990), active treatment reduced the incidence of cardiovascular events, but not that of ...
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13
Hypertension and Outcomes Research
https://dlin.web.unc.edu/wp-content/uploads/sites/1568/2013/04/PsatyEA96.pdf
blood pressure or extent of carotid atherosclerosis, ... in large clinical trials. ... ized clinical trials and the use of major disease end.
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https://dlin.web.unc.edu/wp-content/uploads/sites/1568/2013/04/PsatyEA96.pdf
blood pressure or extent of carotid atherosclerosis, ... in large clinical trials. ... ized clinical trials and the use of major disease end.
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14
Home blood pressure monitors owned by participants in a ...
https://discovery.dundee.ac.uk/en/publications/home-blood-pressure-monitors-owned-by-participants-in-a-large-dec
The TIME study is a decentralised randomised trial investigating the effect of antihypertensive medication dosing time on cardiovascular outcomes in adults with ...
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https://discovery.dundee.ac.uk/en/publications/home-blood-pressure-monitors-owned-by-participants-in-a-large-dec
The TIME study is a decentralised randomised trial investigating the effect of antihypertensive medication dosing time on cardiovascular outcomes in adults with ...
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15
Physician (investigator) inertia in apparent treatment-resistant ...
https://www.tandfonline.com/doi/full/10.3109/08037051.2014.946787
Treatment of resistant hypertension has attained much attention during the past few years ... hypertension – Insights from large randomized clinical trials.
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https://www.tandfonline.com/doi/full/10.3109/08037051.2014.946787
Treatment of resistant hypertension has attained much attention during the past few years ... hypertension – Insights from large randomized clinical trials.
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16
Will the recent hypertension trials change the guidelines?
https://journals.sagepub.com/doi/10.1177/1470320317710891
The first of these trials, PATHWAY 1, was designed to test the hypothesis that hypertensive patients initially randomised to monotherapy, with subsequent ...
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https://journals.sagepub.com/doi/10.1177/1470320317710891
The first of these trials, PATHWAY 1, was designed to test the hypothesis that hypertensive patients initially randomised to monotherapy, with subsequent ...
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17
Clinical trial design and new therapies for pulmonary arterial ...
https://erj.ersjournals.com/content/53/1/1801908
Main recent clinical trials in pulmonary arterial hypertension with either ... Morbidity and mortality event trials require large numbers of subjects ...
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https://erj.ersjournals.com/content/53/1/1801908
Main recent clinical trials in pulmonary arterial hypertension with either ... Morbidity and mortality event trials require large numbers of subjects ...
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18
Impact of recent landmark clinical trials on hypertension ...
https://www.openaccessjournals.com/articles/impact-of-recent-landmark-clinical-trials-on-hypertension-treatment.pdf
mendations for hypertension treatment from guidelines are based on consensus, most are dependent on evidence from large clinical drug trials or ...
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https://www.openaccessjournals.com/articles/impact-of-recent-landmark-clinical-trials-on-hypertension-treatment.pdf
mendations for hypertension treatment from guidelines are based on consensus, most are dependent on evidence from large clinical drug trials or ...
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19
High Blood Pressure (Hypertension) Clinical Trials
https://www.mayo.edu/research/clinical-trials/diseases-conditions/high-blood-pressure-(hypertension)
› research › diseases-conditions
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https://www.mayo.edu/research/clinical-trials/diseases-conditions/high-blood-pressure-(hypertension)
› research › diseases-conditions
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20
Intensive versus Standard Therapy for Hypertension
https://clinmedjournals.org/articles/jhm/journal-of-hypertension-and-management-jhm-2-019.php?jid=jhm
The primary hypothesis for the Systolic Blood Pressure Intervention Trial (SPRINT) is that treating to a systolic blood pressure target of < 120 mmHg (the ...
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https://clinmedjournals.org/articles/jhm/journal-of-hypertension-and-management-jhm-2-019.php?jid=jhm
The primary hypothesis for the Systolic Blood Pressure Intervention Trial (SPRINT) is that treating to a systolic blood pressure target of < 120 mmHg (the ...
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21
The First Hypertension Trial Comparing the Effects of Two ...
https://onlinelibrary.wiley.com/doi/10.1111/j.1524-6175.2003.02676.x
It is time to look at a new paradigm in hypertension trials. The ACCOMPLISH trial is the first large, randomized hypertension clinical trial to ...
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https://onlinelibrary.wiley.com/doi/10.1111/j.1524-6175.2003.02676.x
It is time to look at a new paradigm in hypertension trials. The ACCOMPLISH trial is the first large, randomized hypertension clinical trial to ...
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22
The Results of the Clinical Trials in Hypertension - MedCrave
https://medcraveonline.com/JCCR/the-results-of-the-clinical-trials-in-hypertension-unquestionable-benefits-and-limits.html
Lowering blood pressure is the main target to achieve for reducing cardiovascular complications in hypertensive patients. Large-scale trials ...
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https://medcraveonline.com/JCCR/the-results-of-the-clinical-trials-in-hypertension-unquestionable-benefits-and-limits.html
Lowering blood pressure is the main target to achieve for reducing cardiovascular complications in hypertensive patients. Large-scale trials ...
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23
Systolic Blood Pressure Intervention Trial (SPRINT) Protocol ...
https://www.sprinttrial.org/public/Protocol_Current.pdf
Memory and cognition IN Decreased hypertension (SPRINT MIND study) will test ... previous trials, ACCORD did find a large reduction in the incidence of ...
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https://www.sprinttrial.org/public/Protocol_Current.pdf
Memory and cognition IN Decreased hypertension (SPRINT MIND study) will test ... previous trials, ACCORD did find a large reduction in the incidence of ...
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24
Hypertension guidelines, meta-analyses and clinical trials
https://www.mja.com.au/journal/2005/182/2/hypertension-guidelines-meta-analyses-and-clinical-trials-do-we-assume-too-much
by RE Peverill · 2005 · Cited by 10 —
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https://www.mja.com.au/journal/2005/182/2/hypertension-guidelines-meta-analyses-and-clinical-trials-do-we-assume-too-much
by RE Peverill · 2005 · Cited by 10 —
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25
Dementia and disability outcomes in large hypertension trials
https://research.tilburguniversity.edu/en/publications/dementia-and-disability-outcomes-in-large-hypertension-trials-les
Dementia and disability outcomes in large hypertension trials: Lessons learned from the systolic hypertension in the elderly program (SHEP) trial.
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https://research.tilburguniversity.edu/en/publications/dementia-and-disability-outcomes-in-large-hypertension-trials-les
Dementia and disability outcomes in large hypertension trials: Lessons learned from the systolic hypertension in the elderly program (SHEP) trial.
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26
High Blood Pressure (Hypertension) Clinical Research Trials
https://www.centerwatch.com/clinical-trials/listings/condition/85/high-blood-pressure-hypertension/
A listing of High Blood Pressure (Hypertension) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed ...
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https://www.centerwatch.com/clinical-trials/listings/condition/85/high-blood-pressure-hypertension/
A listing of High Blood Pressure (Hypertension) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed ...
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27
Choice of drug therapy in primary (essential) hypertension
https://www.uptodate.com/contents/choice-of-drug-therapy-in-primary-essential-hypertension
However, three subsequent, large trials performed in patients with a history of atrial fibrillation found that these drugs do not prevent ...
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https://www.uptodate.com/contents/choice-of-drug-therapy-in-primary-essential-hypertension
However, three subsequent, large trials performed in patients with a history of atrial fibrillation found that these drugs do not prevent ...
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28
Antihypertensives: Landmark & Recent Trials - RxFiles
https://www.rxfiles.ca/rxfiles/uploads/documents/HTNLandmarkHypertensionTrials.pdf
Combination therapy with perindopril & indapamide produced larger blood pressure reductions & larger risk reductions than did single drug therapy with ...
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https://www.rxfiles.ca/rxfiles/uploads/documents/HTNLandmarkHypertensionTrials.pdf
Combination therapy with perindopril & indapamide produced larger blood pressure reductions & larger risk reductions than did single drug therapy with ...
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29
UCSF High Blood Pressure Clinical Trials for 2022
https://clinicaltrials.ucsf.edu/high-blood-pressure
Patients are being asked to be in this research study because medical researchers hope that by gathering information about a large number of ...
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https://clinicaltrials.ucsf.edu/high-blood-pressure
Patients are being asked to be in this research study because medical researchers hope that by gathering information about a large number of ...
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30
Hypertension Control During Pregnancy Validated in Large Trial
https://www.medscape.com/viewarticle/971486
In this trial, 2,408 pregnant women with chronic mild hypertension defined as a blood pressure of 160/90 mm Hg were randomized to treatment ...
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https://www.medscape.com/viewarticle/971486
In this trial, 2,408 pregnant women with chronic mild hypertension defined as a blood pressure of 160/90 mm Hg were randomized to treatment ...
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31
guideline-clinical-investigation-medicinal-products-treatment ...
https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-clinical-investigation-medicinal-products-treatment-hypertension-revision-4_en.pdf
In many hypertensive patients the treatment goals for BP cannot be achieved by one drug alone. This has been shown in several large trials, ...
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https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-clinical-investigation-medicinal-products-treatment-hypertension-revision-4_en.pdf
In many hypertensive patients the treatment goals for BP cannot be achieved by one drug alone. This has been shown in several large trials, ...
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32
Transcutaneous electrical acupoint stimulation for stage 1 ...
https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04493-x
The study will be a two-arm parallel, randomized controlled trial. Sixty patients with stage 1 hypertension will be randomly assigned to the ...
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https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04493-x
The study will be a two-arm parallel, randomized controlled trial. Sixty patients with stage 1 hypertension will be randomly assigned to the ...
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33
Chronic Hypertension and Pregnancy - CHAP
https://www.acc.org/Latest-in-Cardiology/Clinical-Trials/2022/04/01/03/19/CHAP
The CHAP trial showed that antihypertensive therapy improves ... A large proportion of non-Hispanic blacks were enrolled in this trial.
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https://www.acc.org/Latest-in-Cardiology/Clinical-Trials/2022/04/01/03/19/CHAP
The CHAP trial showed that antihypertensive therapy improves ... A large proportion of non-Hispanic blacks were enrolled in this trial.
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34
BPLTTC
http://www.bplttc.org/
The Blood Pressure Lowering Treatment Trialists' Collaboration (BPLTTC). ... of some of the largest trials included in the BPLTTC and chaired by Dr Kazem ...
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http://www.bplttc.org/
The Blood Pressure Lowering Treatment Trialists' Collaboration (BPLTTC). ... of some of the largest trials included in the BPLTTC and chaired by Dr Kazem ...
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35
The First Hypertension Trial Comparing the Effects of Two ...
http://deepblue.lib.umich.edu/bitstream/handle/2027.42/73430/j.1524-6175.2003.02676.x.pdf?sequence=1
trial, Avoiding Cardiovascular Events through. Combination Therapy in Patients Living with. Systolic Hypertension (ACCOMPLISH), is the first large clinical ...
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http://deepblue.lib.umich.edu/bitstream/handle/2027.42/73430/j.1524-6175.2003.02676.x.pdf?sequence=1
trial, Avoiding Cardiovascular Events through. Combination Therapy in Patients Living with. Systolic Hypertension (ACCOMPLISH), is the first large clinical ...
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36
UTSW algorithm identifies hypertensive patients who will ...
https://www.utsouthwestern.edu/newsroom/articles/year-2018/hypertension-algorithm.html
Using data from large clinical trials, UT Southwestern researchers developed a way to predict which patients will benefit most from ...
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https://www.utsouthwestern.edu/newsroom/articles/year-2018/hypertension-algorithm.html
Using data from large clinical trials, UT Southwestern researchers developed a way to predict which patients will benefit most from ...
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37
Clinical Trial on Hypertension: Amlodipine - ICH GCP
https://ichgcp.net/clinical-trials-registry/NCT04559074
This trial is focusing on blood pressure control for patients with high blood pressure (hypertension) during the COVID-19 pandemic when seeing a doctor for ...
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https://ichgcp.net/clinical-trials-registry/NCT04559074
This trial is focusing on blood pressure control for patients with high blood pressure (hypertension) during the COVID-19 pandemic when seeing a doctor for ...
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38
Practice Implications of Recent Hypertension and Lipid Trials
https://www.medscape.org/viewarticle/457696_7
This activity will provide practitioners with an overview of recent hypertension and lipid trials. The Antihypertensive and Lipid-Lowering Treatment to Prevent ...
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https://www.medscape.org/viewarticle/457696_7
This activity will provide practitioners with an overview of recent hypertension and lipid trials. The Antihypertensive and Lipid-Lowering Treatment to Prevent ...
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39
University of California Health High Blood Pressure Clinical ...
https://clinicaltrials.ucbraid.org/high-blood-pressure
High Blood Pressure clinical trials at University of California Health ... Comparing Ascites Relief In Two Standard Treatments: Large Volume ...
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https://clinicaltrials.ucbraid.org/high-blood-pressure
High Blood Pressure clinical trials at University of California Health ... Comparing Ascites Relief In Two Standard Treatments: Large Volume ...
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40
George Medicines initiates two Phase III trials of triple
https://www.globenewswire.com/en/news-release/2021/07/01/2256368/0/en/George-Medicines-initiates-two-Phase-III-trials-of-triple-combination-candidate-to-treat-hypertension.html
Recent hypertension guidelines recommend combination therapy as initial treatment for many or most patients1 and a previous trial indicated ...
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https://www.globenewswire.com/en/news-release/2021/07/01/2256368/0/en/George-Medicines-initiates-two-Phase-III-trials-of-triple-combination-candidate-to-treat-hypertension.html
Recent hypertension guidelines recommend combination therapy as initial treatment for many or most patients1 and a previous trial indicated ...
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41
Studies that changed clinical practice Evidence for the ...
https://www.pcdsociety.org/resources/details/studies-that-changed-clinical-practice-evidence-for-the-management-of-hypertension-in-diabetes-the-key-studies
Trial evidence for the management of hypertension. Epidemiologic analyses show that BP greater than 115/75 mmHg is associated with increased ...
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https://www.pcdsociety.org/resources/details/studies-that-changed-clinical-practice-evidence-for-the-management-of-hypertension-in-diabetes-the-key-studies
Trial evidence for the management of hypertension. Epidemiologic analyses show that BP greater than 115/75 mmHg is associated with increased ...
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42
A Randomized, Double Blind, Placebo-Controlled, Multicenter ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117560
Allisartan Isoproxil 240mg was effective and safe for essential hypertension patients at low-medium risk. Trial Registration. http://www.chictr.
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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117560
Allisartan Isoproxil 240mg was effective and safe for essential hypertension patients at low-medium risk. Trial Registration. http://www.chictr.
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43
After the ALLHAT Trial, What Do we Know About Treatment for ...
https://www.revespcardiol.org/en-after-allhat-trial-what-do-articulo-13049667
This conclusion has been refined in a number of ways. For example, because a large proportion of patients registered high blood pressure throughout follow-up in ...
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https://www.revespcardiol.org/en-after-allhat-trial-what-do-articulo-13049667
This conclusion has been refined in a number of ways. For example, because a large proportion of patients registered high blood pressure throughout follow-up in ...
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44
Methods of Blood Pressure Assessment Used in Milestone ...
https://www.karger.com/Article/Fulltext/489855
In the present review, we summarized the blood pressure (BP) measurement protocols of contemporary outcome trials in hypertension.
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https://www.karger.com/Article/Fulltext/489855
In the present review, we summarized the blood pressure (BP) measurement protocols of contemporary outcome trials in hypertension.
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45
High blood pressure: Trial questions current standards | Heart
https://utswmed.org/medblog/hypertension-systolic-trial/
The findings from this trial called into question our national standard for safe blood pressure levels for high-risk hypertension patients – ...
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https://utswmed.org/medblog/hypertension-systolic-trial/
The findings from this trial called into question our national standard for safe blood pressure levels for high-risk hypertension patients – ...
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46
Taking Hypertension Medication at Bedtime Improves CVD Risk
https://www.aafp.org/news/health-of-the-public/20191106bedtimehbpmeds.html
The Hygia Chronotherapy Trial found bedtime hypertension therapy better reduced the risk of cardiovascular disease than taking blood pressure ...
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https://www.aafp.org/news/health-of-the-public/20191106bedtimehbpmeds.html
The Hygia Chronotherapy Trial found bedtime hypertension therapy better reduced the risk of cardiovascular disease than taking blood pressure ...
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47
Chronic Hypertension and Pregnancy (CHAP) Project
https://clinicaltrials.ucsd.edu/trial/NCT02299414
Therefore, our multicenter consortium proposes the Chronic Hypertension and Pregnancy (CHAP) Project, a large pragmatic randomized trial with a primary aim to ...
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https://clinicaltrials.ucsd.edu/trial/NCT02299414
Therefore, our multicenter consortium proposes the Chronic Hypertension and Pregnancy (CHAP) Project, a large pragmatic randomized trial with a primary aim to ...
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48
Evaluating Recent Therapeutic Trials in Pulmonary Arterial ...
https://meridian.allenpress.com/aph/article/8/1/24/432086/Evaluating-Recent-Therapeutic-Trials-in-Pulmonary
Advances in Pulmonary Hypertension (2009) 8 (1): 24–31. ... clinical trial, which reports the mean change in a large group of patients with ...
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https://meridian.allenpress.com/aph/article/8/1/24/432086/Evaluating-Recent-Therapeutic-Trials-in-Pulmonary
Advances in Pulmonary Hypertension (2009) 8 (1): 24–31. ... clinical trial, which reports the mean change in a large group of patients with ...
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49
Patients with Pulmonary Arterial Hypertension in Clinical Trials
https://www.atsjournals.org/doi/full/10.1513/pats.200803-032SK
The largest bosentan RCT, BREATHE 1 (Bosentan Randomized Trial of Endothelin Receptor Antagonist Therapy for Pulmonary Hypertension), ...
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https://www.atsjournals.org/doi/full/10.1513/pats.200803-032SK
The largest bosentan RCT, BREATHE 1 (Bosentan Randomized Trial of Endothelin Receptor Antagonist Therapy for Pulmonary Hypertension), ...
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50
A Big Hypertension Study, and Its Minimal Impact
https://www.nytimes.com/2008/11/28/business/28govtest.html
Critics said the rules of the trial had favored the diuretics. If the first drug did not adequately lower blood pressure — as happened in ...
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https://www.nytimes.com/2008/11/28/business/28govtest.html
Critics said the rules of the trial had favored the diuretics. If the first drug did not adequately lower blood pressure — as happened in ...
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51
George Medicines provides single-pill triple combination ...
https://brandonbiocatalyst.com/2022/09/08/george-medicines-provides-single-pill-triple-combination-candidate-for-hypertension-to-veronica-nigeria-trial/
Two Phase III trials are underway investigating the efficacy and safety of GMRx2 as a first-line treatment for hypertension: An international, ...
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https://brandonbiocatalyst.com/2022/09/08/george-medicines-provides-single-pill-triple-combination-candidate-for-hypertension-to-veronica-nigeria-trial/
Two Phase III trials are underway investigating the efficacy and safety of GMRx2 as a first-line treatment for hypertension: An international, ...
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52
COVID-19 Study Paves the Way for an Innovative Virtual ...
https://www.unitedhealthgroup.com/newsroom/posts/2020-05-18-yale-study-hypertension-medication.html
The large-scale research trial led by UnitedHealth Group and Yale ... trials on ACEs to inform appropriate hypertension treatments for ...
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https://www.unitedhealthgroup.com/newsroom/posts/2020-05-18-yale-study-hypertension-medication.html
The large-scale research trial led by UnitedHealth Group and Yale ... trials on ACEs to inform appropriate hypertension treatments for ...
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53
Dementia and Disability Outcomes in Large Hypertension Trials
https://search.ebscohost.com/login.aspx?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=00029262&AN=45264219&h=f5KtiX8KHlvTjMcV8ZdaLCGZxN2NWlhnMKTHC5oIuKdCfrQ%2BRO6B4Cu%2BmIvcg9bT0S1hmr3cur5TRrosi8AKlA%3D%3D&crl=f
In the Systolic Hypertension in the Elderly Program (SHEP) trial (1985–1990), active treatment reduced the incidence of cardiovascular events, ...
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https://search.ebscohost.com/login.aspx?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=00029262&AN=45264219&h=f5KtiX8KHlvTjMcV8ZdaLCGZxN2NWlhnMKTHC5oIuKdCfrQ%2BRO6B4Cu%2BmIvcg9bT0S1hmr3cur5TRrosi8AKlA%3D%3D&crl=f
In the Systolic Hypertension in the Elderly Program (SHEP) trial (1985–1990), active treatment reduced the incidence of cardiovascular events, ...
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54
Pilot Results of a Digital Hypertension Self-management ...
https://formative.jmir.org/2022/3/e33057
Methods: A single-arm, nonrandomized trial was performed to evaluate a digital HTN self-management program that combines comprehensive lifestyle ...
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https://formative.jmir.org/2022/3/e33057
Methods: A single-arm, nonrandomized trial was performed to evaluate a digital HTN self-management program that combines comprehensive lifestyle ...
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55
Prognostic value of improvement endpoints in pulmonary ...
https://www.jhltonline.org/article/S1053-2498(22)01856-3/fulltext
... in pulmonary arterial hypertension trials: A COMPERA analysis ... larger sample sizes and longer follow-up periods than the trials ...
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https://www.jhltonline.org/article/S1053-2498(22)01856-3/fulltext
... in pulmonary arterial hypertension trials: A COMPERA analysis ... larger sample sizes and longer follow-up periods than the trials ...
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56
Alnylam takes biannual hypertension prospect into phase 2 trial
https://www.fiercepharma.com/drug-delivery/alnylam-takes-biannual-hypertension-prospect-into-phase-2-trial
Alnylam has started a phase 2 clinical trial of quarterly and biannual subcutaneous doses of potential hypertension drug zilebesiran.
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https://www.fiercepharma.com/drug-delivery/alnylam-takes-biannual-hypertension-prospect-into-phase-2-trial
Alnylam has started a phase 2 clinical trial of quarterly and biannual subcutaneous doses of potential hypertension drug zilebesiran.
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57
(PDF) Home blood pressure monitors owned by participants in ...
https://www.researchgate.net/publication/349337518_Home_blood_pressure_monitors_owned_by_participants_in_a_large_decentralised_clinical_trial_in_hypertension_the_Treatment_In_Morning_versus_Evening_TIME_study
The TIME study is a decentralised randomised trial investigating the effect of antihypertensive medication dosing time on cardiovascular ...
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https://www.researchgate.net/publication/349337518_Home_blood_pressure_monitors_owned_by_participants_in_a_large_decentralised_clinical_trial_in_hypertension_the_Treatment_In_Morning_versus_Evening_TIME_study
The TIME study is a decentralised randomised trial investigating the effect of antihypertensive medication dosing time on cardiovascular ...
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58
Lancet Paper Shows Most Popular Hypertension Drug Isn't ...
https://www.dbmi.columbia.edu/lancet-legend-hypertension-study/
First-line thiazide new-users experienced three major medical outcomes (heart attack, hospitalization for heart failure, and stroke) at an ...
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https://www.dbmi.columbia.edu/lancet-legend-hypertension-study/
First-line thiazide new-users experienced three major medical outcomes (heart attack, hospitalization for heart failure, and stroke) at an ...
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59
Key Learnings from Recent Hypertension Clinical Trials: What Do ...
http://www.newswise.com/articles/key-learnings-from-recent-hypertension-clinical-trials-what-do-we-know-now?section=latest&previous_id=552071
Initial Drugs for Coronary Heart Disease Prevention in Hypertensive PatientsAll types of initial antihypertensive drug therapy were significantly better at ...
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http://www.newswise.com/articles/key-learnings-from-recent-hypertension-clinical-trials-what-do-we-know-now?section=latest&previous_id=552071
Initial Drugs for Coronary Heart Disease Prevention in Hypertensive PatientsAll types of initial antihypertensive drug therapy were significantly better at ...
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60
Randomized Controlled Trials - Medtronic
https://europe.medtronic.com/xd-en/healthcare-professionals/therapies-procedures/cardiovascular/renal-denervation/clinical-data/randomized-controlled-trials.html
The SPYRAL HTN-OFF MED Pivotal Trial showed that the Symplicity blood pressure procedure had superior blood pressure reductions compared to control at three ...
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https://europe.medtronic.com/xd-en/healthcare-professionals/therapies-procedures/cardiovascular/renal-denervation/clinical-data/randomized-controlled-trials.html
The SPYRAL HTN-OFF MED Pivotal Trial showed that the Symplicity blood pressure procedure had superior blood pressure reductions compared to control at three ...
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61
CinCor Pharma Announces Topline Data for ... - Yahoo Finance
https://www.yahoo.com/now/cincor-pharma-announces-topline-data-123000488.html
Primary endpoint in Intention to Treat (ITT) was not met despite large absolute reductions in Systolic Blood Pressure (SBP) 12.6 mmHg ...
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https://www.yahoo.com/now/cincor-pharma-announces-topline-data-123000488.html
Primary endpoint in Intention to Treat (ITT) was not met despite large absolute reductions in Systolic Blood Pressure (SBP) 12.6 mmHg ...
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62
LECANEMAB CONFIRMATORY PHASE 3 CLARITY AD ...
https://investors.biogen.com/news-releases/news-release-details/lecanemab-confirmatory-phase-3-clarity-ad-study-met-primary
... large global Phase 3 confirmatory Clarity AD clinical trial of ... with a broad range of comorbidities/comedications: hypertension, ...
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https://investors.biogen.com/news-releases/news-release-details/lecanemab-confirmatory-phase-3-clarity-ad-study-met-primary
... large global Phase 3 confirmatory Clarity AD clinical trial of ... with a broad range of comorbidities/comedications: hypertension, ...
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63
Definition of cohort - NCI Dictionary of Cancer Terms
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/cohort
... a common trait, such as birth year. In medicine, a cohort is a group that is part of a clinical trial or study and is observed over a period of time.
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https://www.cancer.gov/publications/dictionaries/cancer-terms/def/cohort
... a common trait, such as birth year. In medicine, a cohort is a group that is part of a clinical trial or study and is observed over a period of time.
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64
CinCor shares dive after blood pressure drug fails key trial
https://www.biopharmadive.com/news/cincor-hypertension-blood-pressure-drug-trial-results/637406/
Investors instead got a surprise, as what Ding described as a “huge placebo effect” caused baxdrostat to miss the main study goal. In a press ...
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https://www.biopharmadive.com/news/cincor-hypertension-blood-pressure-drug-trial-results/637406/
Investors instead got a surprise, as what Ding described as a “huge placebo effect” caused baxdrostat to miss the main study goal. In a press ...
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65
Clinical trial - Wikipedia
https://en.wikipedia.org/wiki/Clinical_trial
Clinical trials are prospective biomedical or behavioral research studies on human ... and subsequently conduct progressively larger scale comparative studies.
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https://en.wikipedia.org/wiki/Clinical_trial
Clinical trials are prospective biomedical or behavioral research studies on human ... and subsequently conduct progressively larger scale comparative studies.
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66
LECANEMAB CONFIRMATORY PHASE 3 CLARITY ... - Eisai
https://www.eisai.com/news/2022/news202271.html
... Eisai's large global Phase 3 confirmatory Clarity AD clinical trial of ... range of comorbidities/comedications: hypertension, diabetes, ...
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https://www.eisai.com/news/2022/news202271.html
... Eisai's large global Phase 3 confirmatory Clarity AD clinical trial of ... range of comorbidities/comedications: hypertension, diabetes, ...
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67
CinCor Pharma Announces Topline Data for ... - BioSpace
https://www.biospace.com/article/releases/cincor-pharma-announces-topline-data-for-phase-2-halo-trial-evaluating-selective-aldosterone-synthase-inhibitor-baxdrostat-in-uncontrolled-hypertension/
CinCor Pharma Announces Topline Data for Phase 2 HALO Trial ... not met despite large absolute reductions in Systolic Blood Pressure (SBP).
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https://www.biospace.com/article/releases/cincor-pharma-announces-topline-data-for-phase-2-halo-trial-evaluating-selective-aldosterone-synthase-inhibitor-baxdrostat-in-uncontrolled-hypertension/
CinCor Pharma Announces Topline Data for Phase 2 HALO Trial ... not met despite large absolute reductions in Systolic Blood Pressure (SBP).
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68
CinCor's hypertension drug loses halo after phase 2 fail
https://www.fiercebiotech.com/biotech/cincors-hypertension-drug-loses-its-halo-after-phase-2-fail-plunging-stock-44
The phase 2 HALO trial was evaluating the efficacy and safety of a highly selective aldosterone synthase inhibitor called baxdrostat in 249 patients with ...
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https://www.fiercebiotech.com/biotech/cincors-hypertension-drug-loses-its-halo-after-phase-2-fail-plunging-stock-44
The phase 2 HALO trial was evaluating the efficacy and safety of a highly selective aldosterone synthase inhibitor called baxdrostat in 249 patients with ...
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69
NIH hypertension study makes a stronger case for aiming for ...
https://hscweb3.hsc.usf.edu/blog/2015/10/02/nih-hypertension-study-makes-a-stronger-case-for-aiming-for-even-lower-blood-pressure/
The Systolic Blood Pressure Intervention Trial, nicknamed SPRINT study, aimed to see if using multiple targeted medications to reduce the ...
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https://hscweb3.hsc.usf.edu/blog/2015/10/02/nih-hypertension-study-makes-a-stronger-case-for-aiming-for-even-lower-blood-pressure/
The Systolic Blood Pressure Intervention Trial, nicknamed SPRINT study, aimed to see if using multiple targeted medications to reduce the ...
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70
Finding a New Treatment for High Blood Pressure
https://www.rwjbh.org/blog/2019/june/finding-a-new-treatment-for-high-blood-pressure/
Torre and his team expressed interest in joining the trial, and were selected because the hospital treats a large number of hypertension ...
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https://www.rwjbh.org/blog/2019/june/finding-a-new-treatment-for-high-blood-pressure/
Torre and his team expressed interest in joining the trial, and were selected because the hospital treats a large number of hypertension ...
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71
Guideline-Driven Management of Hypertension - YouTube
https://www.youtube.com/watch?v=zsHIvtbBxzM
American Heart Association
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https://www.youtube.com/watch?v=zsHIvtbBxzM
American Heart Association
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72
Step 3: Clinical Research - FDA
https://www.fda.gov/patients/drug-development-process/step-3-clinical-research
Clinical trials follow a typical series from early, small-scale, Phase 1 studies to late-stage, large scale, Phase 3 studies.
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https://www.fda.gov/patients/drug-development-process/step-3-clinical-research
Clinical trials follow a typical series from early, small-scale, Phase 1 studies to late-stage, large scale, Phase 3 studies.
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73
Merck | Home
https://www.merck.com/
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https://www.merck.com/
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74
High blood pressure (hypertension) - Diagnosis and treatment
https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/diagnosis-treatment/drc-20373417
Clinical trials. Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage ...
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https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/diagnosis-treatment/drc-20373417
Clinical trials. Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage ...
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75
Top 10 Hypertension Clinical Trials [2022 Studies] - Power
https://www.withpower.com/clinical-trials/hypertension
Clinical trials for hypertension help those at risk of developing hypertension and those diagnosed with hypertension. In addition, these clinical trials will ...
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https://www.withpower.com/clinical-trials/hypertension
Clinical trials for hypertension help those at risk of developing hypertension and those diagnosed with hypertension. In addition, these clinical trials will ...
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76
Taking blood pressure meds may reduce risk of dementia - CNN
https://www.cnn.com/2022/10/28/health/blood-pressure-dementia-wellness
The study, published this week in the European Heart Journal, combined data from five large randomized, double-blinded clinical trials of more ...
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https://www.cnn.com/2022/10/28/health/blood-pressure-dementia-wellness
The study, published this week in the European Heart Journal, combined data from five large randomized, double-blinded clinical trials of more ...
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77
Novartis
https://www.novartis.com/
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https://www.novartis.com/
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78
AbbVie | Pharmaceutical Research & Development
https://www.abbvie.com/
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https://www.abbvie.com/
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79
CinCor Pharma Announces Topline Data for ... - MarketScreener
https://www.marketscreener.com/quote/stock/CINCOR-PHARMA-INC-131369220/news/CinCor-Pharma-Announces-Topline-Data-for-Phase-2-HALO-Trial-Evaluating-Selective-Aldosterone-Synthas-42418915/
“The results of the two Phase 2 trials, involving over 500 patients ... options for the large numbers of patients whose hypertension remains ...
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https://www.marketscreener.com/quote/stock/CINCOR-PHARMA-INC-131369220/news/CinCor-Pharma-Announces-Topline-Data-for-Phase-2-HALO-Trial-Evaluating-Selective-Aldosterone-Synthas-42418915/
“The results of the two Phase 2 trials, involving over 500 patients ... options for the large numbers of patients whose hypertension remains ...
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80
Cereno Scientific participates at the 19th Global CVCT Forum ...
https://news.cision.com/cereno-scientific/r/cereno-scientific-participates-at-the-19th-global-cvct-forum-2022-discussing-clinical-trials-in-card,c3675999
Pulmonary arterial hypertension trials (part 1): New pathways and new ... leaders and top executives of large pharmaceutical companies, ...
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https://news.cision.com/cereno-scientific/r/cereno-scientific-participates-at-the-19th-global-cvct-forum-2022-discussing-clinical-trials-in-card,c3675999
Pulmonary arterial hypertension trials (part 1): New pathways and new ... leaders and top executives of large pharmaceutical companies, ...
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81
CinCor Plans Baxdrostat Phase III Despite Phase II Miss In ...
https://scrip.pharmaintelligence.informa.com/SC147440/CinCor-Plans-Baxdrostat-Phase-III-Despite-Phase-II-Miss-In-Uncontrolled-Hypertension
With subgroup analysis that it claims shows efficacy in non-Hispanics and success in a previous Phase II in treatment-resistant hypertension ...
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https://scrip.pharmaintelligence.informa.com/SC147440/CinCor-Plans-Baxdrostat-Phase-III-Despite-Phase-II-Miss-In-Uncontrolled-Hypertension
With subgroup analysis that it claims shows efficacy in non-Hispanics and success in a previous Phase II in treatment-resistant hypertension ...
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82
When targeting high BP, draw on this evidence-based ...
https://www.ama-assn.org/delivering-care/hypertension/when-targeting-high-bp-draw-evidence-based-framework
A recent article in The Journal of Clinical Hypertension provides a ... shown in randomized controlled trials to lower blood pressure as ...
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https://www.ama-assn.org/delivering-care/hypertension/when-targeting-high-bp-draw-evidence-based-framework
A recent article in The Journal of Clinical Hypertension provides a ... shown in randomized controlled trials to lower blood pressure as ...
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83
Few clinical studies examine high blood pressure treatments ...
https://www.heart.org/en/news/2020/12/07/few-clinical-studies-examine-high-blood-pressure-treatments-for-black-americans
The analysis, published Monday in the Journal of the American Heart Association, found that of the 956 U.S.-based clinical trials investigating ...
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https://www.heart.org/en/news/2020/12/07/few-clinical-studies-examine-high-blood-pressure-treatments-for-black-americans
The analysis, published Monday in the Journal of the American Heart Association, found that of the 956 U.S.-based clinical trials investigating ...
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84
Teasing Out the Nuance in Hypertension Guidelines
https://www.medpagetoday.com/podcasts/ap-cardiology/82821
The hypertension blood pressure threshold is 130/80 mm Hg, right? ... Many of the large, randomized clinical trials that showed benefit to ...
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https://www.medpagetoday.com/podcasts/ap-cardiology/82821
The hypertension blood pressure threshold is 130/80 mm Hg, right? ... Many of the large, randomized clinical trials that showed benefit to ...
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85
Causes Of High Diastolic Blood Pressure And What You Can ...
https://healthmatch.io/high-blood-pressure/what-causes-high-diastolic-blood-pressure
Have you considered clinical trials for High blood pressure? ... with as large a reduction as 5–7mm Hg in systolic and diastolic blood pressure in people ...
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https://healthmatch.io/high-blood-pressure/what-causes-high-diastolic-blood-pressure
Have you considered clinical trials for High blood pressure? ... with as large a reduction as 5–7mm Hg in systolic and diastolic blood pressure in people ...
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86
2022-11-28 | NDAQ:CINC | Press Release | CinCor Pharma Inc.
https://stockhouse.com/news/press-releases/2022/11/28/cincor-pharma-announces-topline-data-for-phase-2-halo-trial-evaluating-selective
CinCor Pharma Announces Topline Data for Phase 2 HALO Trial ... options for the large numbers of patients whose hypertension remains ...
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https://stockhouse.com/news/press-releases/2022/11/28/cincor-pharma-announces-topline-data-for-phase-2-halo-trial-evaluating-selective
CinCor Pharma Announces Topline Data for Phase 2 HALO Trial ... options for the large numbers of patients whose hypertension remains ...
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87
18 foods that help lower blood pressure - Medical News Today
https://www.medicalnewstoday.com/articles/322284
People with kidney disease should consult a doctor before increasing their intake of potassium, as too much can be harmful. A serving would be 1 large banana, 1 ...
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https://www.medicalnewstoday.com/articles/322284
People with kidney disease should consult a doctor before increasing their intake of potassium, as too much can be harmful. A serving would be 1 large banana, 1 ...
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88
The 5 Known Side Effects of Paxlovid (the COVID-19 Pill)
https://www.goodrx.com/paxlovid/known-side-effects
Around 1% of people who took Paxlovid in clinical trials reported this side effect. Your blood pressure should return to normal after ...
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https://www.goodrx.com/paxlovid/known-side-effects
Around 1% of people who took Paxlovid in clinical trials reported this side effect. Your blood pressure should return to normal after ...
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89
CinCor Pharma Announces Toplin - GuruFocus.com
https://www.gurufocus.com/news/1899995/cincor-pharma-announces-topline-data-for-phase-2-halo-trial-evaluating-selective-aldosterone-synthase-inhibitor-baxdrostat-in-uncontrolled-hypertension
CinCor Pharma Announces Topline Data for Phase 2 HALO Trial ... not met despite large absolute reductions in Systolic Blood Pressure (SBP).
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https://www.gurufocus.com/news/1899995/cincor-pharma-announces-topline-data-for-phase-2-halo-trial-evaluating-selective-aldosterone-synthase-inhibitor-baxdrostat-in-uncontrolled-hypertension
CinCor Pharma Announces Topline Data for Phase 2 HALO Trial ... not met despite large absolute reductions in Systolic Blood Pressure (SBP).
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90
Confidence Intervals - SPH - Boston University
https://sphweb.bumc.bu.edu/otlt/mph-modules/bs/bs704_confidence_intervals/bs704_confidence_intervals_print.html
Because the sample is large, we can generate a 95% confidence interval for systolic blood pressure using the following formula:.
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https://sphweb.bumc.bu.edu/otlt/mph-modules/bs/bs704_confidence_intervals/bs704_confidence_intervals_print.html
Because the sample is large, we can generate a 95% confidence interval for systolic blood pressure using the following formula:.
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91
Diet can lower risk of cardiovascular disease - EurekAlert!
https://www.eurekalert.org/news-releases/972813
First published in 1997, the DASH trial demonstrated that, among adults with elevated blood pressure and hypertension, the DASH diet not ...
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https://www.eurekalert.org/news-releases/972813
First published in 1997, the DASH trial demonstrated that, among adults with elevated blood pressure and hypertension, the DASH diet not ...
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92
EISAI PRESENTS FULL RESULTS OF LECANEMAB PHASE ...
https://www.prnewswire.com/news-releases/eisai-presents-full-results-of-lecanemab-phase-3-confirmatory-clarity-ad-study-for-early-alzheimers-disease-at-clinical-trials-on-alzheimers-disease-ctad-conference-301689627.html
Modeling simulations based on the phase 2 trial data suggest that ... of full results or results from later stage or larger scale clinical ...
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https://www.prnewswire.com/news-releases/eisai-presents-full-results-of-lecanemab-phase-3-confirmatory-clarity-ad-study-for-early-alzheimers-disease-at-clinical-trials-on-alzheimers-disease-ctad-conference-301689627.html
Modeling simulations based on the phase 2 trial data suggest that ... of full results or results from later stage or larger scale clinical ...
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93
DASH diet offers even more benefits for Black adults and women
https://news.harvard.edu/gazette/story/2022/11/dash-diet-offers-even-more-benefits-for-black-adults-and-women/
First published in 1997, the DASH trial demonstrated that, among adults with elevated blood pressure and hypertension, the DASH diet not ...
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https://news.harvard.edu/gazette/story/2022/11/dash-diet-offers-even-more-benefits-for-black-adults-and-women/
First published in 1997, the DASH trial demonstrated that, among adults with elevated blood pressure and hypertension, the DASH diet not ...
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94
Invex Therapeutics to begin recruiting IIH patients in NZ for ...
https://smallcaps.com.au/invex-therapeutics-recruiting-iih-patients-nz-clinical-trial-regulatory-approvals/
... clinical trial into New Zealand, where it will evaluate its drug Presendin in patients with idiopathic intracranial hypertension (IIH).
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https://smallcaps.com.au/invex-therapeutics-recruiting-iih-patients-nz-clinical-trial-regulatory-approvals/
... clinical trial into New Zealand, where it will evaluate its drug Presendin in patients with idiopathic intracranial hypertension (IIH).
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95
"Controlling High Blood Pressure: An Evidence-Based ...
https://jdc.jefferson.edu/phlspoptalk/29/
He initiated the clinical trials center, the biomedical ethics center, the humanities in medicine program, the generalist medicine program, the ...
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https://jdc.jefferson.edu/phlspoptalk/29/
He initiated the clinical trials center, the biomedical ethics center, the humanities in medicine program, the generalist medicine program, the ...
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