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1 Age-dependent deterioration of nuclear pore complexes ...
https://pubmed.ncbi.nlm.nih.gov/19167330/
The finding that nuclear pore structure and function deteriorates with age suggests that the presence of the same nucleoporins during the entire life span of ...
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2 Nuclear pore complex maintenance and ... - Cell Press
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(21)00202-6
Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell. 2009; 136: 284-295. View in ...
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3 Age-dependent deterioration of nuclear pore assembly in ...
https://elifesciences.org/articles/48186
The presence of herniations at the nuclear envelope of aged cells suggests that misassembled NPCs are accumulated in aged cells. Aged cells show ...
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4 Poor old pores—The challenge of making and ... - FEBS Press
https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15205
In baker's yeast, the nuclear pore complex (NPC; Box 1) is among the most substoichiometric complexes in replicative aging cells [2].
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5 Altering nuclear pore complex function impacts longevity and ...
https://rupress.org/jcb/article/208/6/729/38098/Altering-nuclear-pore-complex-function-impacts
Aging is a degenerative process caused by an accumulation of damage that leads to reduced viability or survival. · NPCs maintain a selective ...
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6 Nuclear pore complexes in development and tissue ...
https://journals.biologists.com/dev/article/147/23/dev183442/225943/Nuclear-pore-complexes-in-development-and-tissue
Nuclear pore complexes are multiprotein channels that span the nuclear envelope, which connects the nucleus to the cytoplasm.
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7 Modulation of Cell Identity by Modification of Nuclear Pore ...
https://www.frontiersin.org/articles/10.3389/fgene.2019.01301/full
Nuclear pore complexes (NPCs) are multi-protein assemblies that forms channels in the nuclear envelope thus connecting the nucleus and cytoplasm ...
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8 Specialization of chromatin-bound nuclear pore ... - bioRxiv
https://www.biorxiv.org/content/10.1101/2021.06.28.450139v1
We show that in replicatively aging yeast cells attachment of DNA circles to NPCs drives the displacement of the NPCs' nuclear basket and ...
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9 Nuclear Envelope and Nuclear Pore Complexes in ...
https://link.springer.com/article/10.1007/s12035-020-02168-x
by N Hachiya · 2021 · Cited by 10 —
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10 The Nuclear Pore Complex: Birth, Life, and Death of a Cellular ...
https://www.mdpi.com/2073-4409/11/9/1456
Entire NPCs can be degraded by the autophagy machinery. NPCs can accumulate damage in old age or disease, such as oxidative damage, loss of NUPs or phase- ...
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11 Gating neural development and aging via nuclear pores - Nature
https://www.nature.com/articles/cr201235
Emerging evidence suggests an involvement of nuclear pore components in the regulation of neural differentiation and aging.
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12 The role of the nuclear pore complex in aging of post-mitotic ...
https://www.researchgate.net/publication/42768444_The_role_of_the_nuclear_pore_complex_in_aging_of_post-mitotic_cells
... In post-mitotic cells, nuclear pores do not reassemble and hence some of the proteins that comprise nuclear pore complex have exceptionally ...
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13 Stress and aging in the Nuclear Pore Complex and associated ...
https://www.findaphd.com/phds/project/stress-and-aging-in-the-nuclear-pore-complex-and-associated-cytoskeleton-a-3d-super-resolution-light-and-electron-microscopy-study/?p150436
NPCs are thought to be critical during aging because many nucleoporins are “extremely long-lived proteins” which in post-mitotic tissue (e.g. nerves) have no ...
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14 Specialization of chromatin-bound nuclear ... - Semantic Scholar
https://www.semanticscholar.org/paper/Specialization-of-chromatin-bound-nuclear-pore-Meinema-Aspert/adf7c244f6f0a1fd76c931a8b2ea1ec8b0d27d78
The data indicate that DNA circles accumulating in the mother cell drive aging at least in part by triggering NPC specialization, ...
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15 Martin Hetzer, PhD - Salk Institute
https://www.salk.edu/scientist/martin-hetzer/publications/
The total number of nuclear pore complexes (NPCs) per nucleus varies greatly between different cell types and is known to change during cell differentiation and ...
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16 Full article: The ESCRT-III complex is required for nuclear ...
https://www.tandfonline.com/doi/full/10.1080/19491034.2020.1812872
Cellular aging occurs as a cell loses its ability to maintain homeostasis. Aging cells eliminate damaged cellular compartments and other ...
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17 Nucleo–cytoplasmic transport defects and protein aggregates ...
https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-020-00205-2
Several pieces of evidence suggest a link between neuronal protein inclusions and nuclear pore complex (NPC) damage.
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18 Nuclear Pore Complexes Built to Last, But Not Forever
https://www.alzforum.org/news/research-news/nuclear-pore-complexes-built-last-not-forever
Instead, those proteins have extremely long half-lives, leaving them susceptible to oxidative damage and age-related wear and tear that ...
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19 The role of the nuclear pore complex in aging of post-mitotic ...
https://www.aging-us.com/article/100125/pdf
nuclear pore complexes (NPCs), essential multiprotein ... Age-dependent nuclear pore deterioration is associated with a loss of.
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20 Specialization of chromatin-bound ... - Archive ouverte HAL
https://hal.archives-ouvertes.fr/hal-03451302
Specialization of chromatin-bound nuclear pore complexes promotes yeast aging ... Abstract : The nuclear pore complex (NPC) mediates nearly all exchanges between ...
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21 Poor old pores—The challenge of making and maintaining ...
https://agris.fao.org/agris-search/search.do?recordID=US202100073411
Poor old pores—The challenge of making and maintaining nuclear pore complexes in aging [2020]. Rempel, Irina L.; Steen, Anton; Veenhoff, Liesbeth M.; ...
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22 Wente Lab | Vanderbilt University
https://lab.vanderbilt.edu/wente-lab/
Welcome The nucleus is the soul of the cell, entrusted with protecting the cell's ... Nuclear pore complex proteins affect cell differentiation and aging ...
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23 Article showing that Nuclear Pore Complexes are ...
https://umcgresearch.org/w/article-showing-that-nuclear-pore-complexes-are-compromised-in-ageing-yeast-cells
The NPC is a long-lived and exceptionally large structure. We asked whether NPC quality control is compromised in aging mitotic cells. Our ...
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24 The Nuclear Pore Hypothesis of Neurodegeneration
https://jscholarship.library.jhu.edu/handle/1774.2/61418
... Hypothesis of Neurodegeneration: Dysfunction in the nuclear pore complex ... specific NUPs and may represent the “weakest link” in the aging proteome.
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25 Nuclear Pore Complex Proteins in Alzheimer Disease
https://academic.oup.com/jnen/article/65/1/45/2645242
by LG Sheffield · 2006 · Cited by 103 —
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26 Nuclear Pore Complexes | Max Planck Institute of Biophysics
https://www.biophys.mpg.de/molecular-sociology/nuclear_pores
Nuclear pore complexes (NPCs) are fundamental components of all eukaryotic cells. They are giant channels that perforate the nuclear envelope and mediate ...
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27 Nucleus–cytoplasm cross‐talk in the aging brain - Digital CSIC
https://digital.csic.es/bitstream/10261/215103/1/Benvegn%C3%BBS_Nucleus%E2%80%93cytoplasm.pdf
toplasm and the nucleus is mainly governed by the nuclear pore complexes (NPCs), large protein complexes that span the nuclear.
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28 DNA circles promote yeast ageing in part through stimulating ...
https://biol.ethz.ch/en/news-and-events/d-biol-news/2022/04/dna-circles-promote-yeast-ageing-in-part-through-stimulating-the-reorganization-of-nuclear-pore-complexes.html
Changes in the composition of the Nuclear Pore Complex (NPCs), the gateway between the nucleus and cytoplasm of eukaryotic cells, is a hallmark ...
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29 Nuclear pore proteins and the control of genome functions
http://genesdev.cshlp.org/content/29/4/337.full.html
Nuclear pore complexes (NPCs) are composed of several copies of ∼30 different proteins called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) ...
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30 Analysis of Nuclear Pore Complex Permeability in Mammalian ...
https://experiments.springernature.com/articles/10.1007/978-1-0716-2337-4_4
Accumulating evidence indicate that the permeability barrier of the nucleus can vary in different cellular conditions, during aging and in disease. Here we ...
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31 On the nuclear pore complex and its emerging role in cellular ...
https://aip.scitation.org/doi/10.1063/5.0080480
Moreover, recent studies have suggested a new role for the NPC as a mechanosensor, where the NPC changes its channel diameter depending on the nuclear envelope ...
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32 Caenorhabditis elegans Nucleoporins Nup93 and Nup205 ...
https://www.molbiolcell.org/doi/10.1091/mbc.e03-04-0237
Nuclear pore complexes (NPCs) span the nuclear envelope and mediate communication between the nucleus and the cytoplasm. To obtain insight into the ...
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33 Using nuclear envelope mutations to explore age-related ...
https://portlandpress.com/clinsci/article/134/16/2177/226196/Using-nuclear-envelope-mutations-to-explore-age
Accelerated ageing syndromes such as Hutchinson–Gilford Progerin Syndrome, caused by mutations in genes encoding nuclear envelope proteins, ...
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34 Nuclear Envelope and Aging - diff
http://flipper.diff.org/app/pathways/info/4981
The nuclear envelope (NE) becomes transiently ruptured and repaired during interphase in various human cancer cells. This partial breakdown ...
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35 Leaky membranes: Another sign of old age - EurekAlert!
https://www.eurekalert.org/news-releases/659722
In those cells, the nuclear pore complexes deteriorate with time, eventually losing nucleoporins that are critical for maintaining the pore ...
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36 Discovery of Extremely Long-Lived Proteins May Provide ...
https://www.scripps.edu/newsandviews/e_20120213/savas.html
One of the big mysteries in biology is why cells age. ... of a year in age in the core of the nuclear pore complex,” said Jeffrey Savas, ...
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37 The Structure and Physiology of the Nuclear Pore Complex ...
https://jyi.squarespace.com/s/June-The-structure-and-physiology-of-the-nuclear-pore-complex-and-its-role-in-gene-expression-and-hu.pdf
The Nuclear Pore Complex (NPC) is a protein channel that communicates and transports molecules ... as aging, neurodegenerative diseases and extrapyramidal.
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38 Slide 5. Nuclear Pore Complex
https://web.indstate.edu/thcme/mmmoga/histology/slide05.html
The nuclear pore complex is composed of a double iris diaphragm with eightfold symmetry (inset). When the double diaphragm is "closed", a 9 nm pore remains, ...
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39 Quantitative analysis of nuclear pore complex organization in ...
https://www.life-science-alliance.org/content/5/7/e202201423
The number, distribution, and composition of nuclear pore complexes (NPCs) in the nuclear envelope varies between cell types and changes ...
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40 Structural Plasticity of the Cardiac Nuclear Pore Complex in ...
https://www.ahajournals.org/doi/10.1161/01.RES.84.11.1292
In response to the depletion of Ca2+ stores or ATP/GTP pools, the cardiac nuclear pore complex adopted 2 distinct conformations that led to different ...
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41 The ESCRT-III complex is required for nuclear ... - NSF PAR
https://par.nsf.gov/servlets/purl/10208322
protein; nuclear pore complex; nuclear envelope; meiosis; replicative lifespan; cellular aging. Introduction. Cellular aging occurs as a ...
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42 Maximiliano D'Angelo, Ph.D. | Sanford Burnham Prebys
https://www.sbpdiscovery.org/our-scientists/maximiliano-dangelo-phd
Nuclear pore complexes (NPCs) are multiprotein channels that penetrate the nuclear envelope and act as the gatekeepers of the genome.
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43 Gating neural development and aging via nuclear pores
http://public-files.prbb.org/publicacions/46d809d0-50c4-012f-25ff-263316c03650.pdf
Embedded in the nuclear envelope, nuclear pore complexes (NPCs) are multiprotein channels, whose primary function is exchanging molecules be ...
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44 The Role of Nuclear Pore Complexes in Cell Identity and Aging
https://ouci.dntb.gov.ua/en/works/4vwepgRl/
Nuclear Periphery Takes Center Stage: The Role of Nuclear Pore Complexes in Cell Identity and Aging · List of references · Publications that cite this publication.
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45 Nuclear pore complex in genome organization and gene ...
https://www.scholars.northwestern.edu/en/publications/nuclear-pore-complex-in-genome-organization-and-gene-expression-i
The nuclear pore complexes (NPCs) are large, evolutionarily conserved multiprotein channels embedded in the nuclear envelope of all ...
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46 Poor old pores: The cell's challenge to make and maintain ...
https://research.rug.nl/en/publications/poor-old-pores-the-cells-challenge-to-make-and-maintain-nuclear-p
Nuclear pore complexes (NPCs) are among the largest protein complexes in the eukaryotic cell and are evolutionary conserved.
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47 The nucleoporin ELYS regulates nuclear size by controlling ...
https://www.embopress.org/doi/10.15252/embr.201847283
Using a high-throughput imaging RNAi screen, we identify and mechanistically characterize ELYS, a nucleoporin required for post-mitotic nuclear pore complex ...
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48 Breakdown of Barriers in Cells Clue to Aging Process
https://www.disabled-world.com/health/aging/cell-barriers.php
Like guards controlling access to a gated community, nuclear pore complexes are communication channels that regulate the passage of proteins ...
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49 Nuclear Pore Complex and Nucleo-cytoplasmic transport
https://www.sdbonline.org/sites/fly/aignfam/nucleartransport.htm
Nuclear pore complexes (NPCs) span the nuclear envelope (NE) and mediate nucleocytoplasmic transport. In metazoan oocytes and early embryos, NPCs reside not ...
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50 The Role of Nuclear Pore Complexes in Cell Identity and Aging
https://www.researcher-app.com/paper/5242327
In recent years, the nuclear pore complex (NPC) has emerged as a key player in genome regulation and cellular homeostasis. New discoveries have revealed ...
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51 Revealing structure of nuclear pore's inner ring | EMBL
https://www.embl.org/news/science/1604-nuclear-pore/
The nuclear pore is the biggest, most complicated protein complex in ... to nuclear pores in cancer, during ageing, and in other conditions.
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52 The Nuclear Pore Complex: Nuclear Import, Export, & RAN
https://www.youtube.com/watch?v=sYMoP_dAXsI
Catalyst University
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53 Ageing of the Nuclear Pore Complex - NARCIS.nl
https://www.narcis.nl/research/RecordID/OND1353634/Language/en
Ageing of the Nuclear Pore Complex: relating structure and function ; Period, 10 / 2013 - 10 / 2017 ; Status, Completed ; Research number, OND1353634 ; Data ...
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54 Nuclear pore complexes. Design, or evolution ? - catsboard.com
https://reasonandscience.catsboard.com/t2117-nuclear-pore-complexes-design-or-evolution
For RNA, the gateway to a productive life outside the nucleus is the nuclear pore complex, an amalgamation of 30 kinds of proteins that regulates all traffic ...
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55 One of the Biggest Problems in Biology Has Finally Been Solved
https://www.scientificamerican.com/article/one-of-the-biggest-problems-in-biology-has-finally-been-solved/
There's an age-old adage in biology: structure determines ... There was a whole special issue in Science on the nuclear pore complex.
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56 Nuclear Pore Complexes in Genome Organization, Function and ...
https://books.google.com/books?id=1kFKDwAAQBAJ&pg=PA155&lpg=PA155&dq=nuclear+pore+complex+aging&source=bl&ots=ohhWyYUg-r&sig=ACfU3U1wCvq_8VL0P2MWeAKcwQbzT3qwYw&hl=en&sa=X&ved=2ahUKEwi6gMr7m9n7AhXMCewKHYEBC-oQ6AF6BQijAhAD
... Wet al (2005) Nup155 regulates nuclear envelope and nuclear pore complex ... P (2014b) C. elegans epigenetic regulation in development and aging.
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57 Molecular, Cellular, and Metabolic Fundamentals of Human Aging
https://books.google.com/books?id=3GJjEAAAQBAJ&pg=PA81&lpg=PA81&dq=nuclear+pore+complex+aging&source=bl&ots=9BUeofHBEl&sig=ACfU3U0tLD32tD12GXxcGaagnS9_F7C0Xw&hl=en&sa=X&ved=2ahUKEwi6gMr7m9n7AhXMCewKHYEBC-oQ6AF6BQikAhAD
... in aging-associated dysregulation, because these include central gatekeepers of cellular homeostasis and longevity (e.g., nuclear pore complexes, ...
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58 Nuclear Pore Complex Comes into Focus | Evolution News
https://evolutionnews.org/2022/02/nuclear-pore-complex-comes-into-focus/
Nuclear pore complexes (NPCs) mediate the nucleocytoplasmic transport of macromolecules. Here we provide a structure of the isolated yeast NPC ...
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59 Cell division - Wikipedia
https://en.wikipedia.org/wiki/Cell_division
Cell division gives rise to genetically identical cells in which the total number of chromosomes is maintained. In general, mitosis (division of the nucleus) is ...
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60 Core Pathways of Aging - LessWrong
https://www.lesswrong.com/posts/ui6mDLdqXkaXiDMJ5/core-pathways-of-aging
There's only a handful of genes on it; most necessary mRNA/protein sequence is supplied by the nuclear DNA. But the mitochondria's little DNA is ...
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61 Scientists Map the Architecture of Nuclear Pore Complex in ...
https://scitechdaily.com/scientists-map-architecture-of-nuclear-pore-complex-in-yeast-cells/
A map showing how the 552 pieces of the pore complex fit together could inform research into numerous diseases. Like an island nation, the ...
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62 Molecular Biology News - ScienceDaily
https://www.sciencedaily.com/news/plants_animals/molecular_biology/
17, 2022 — The gene DDX41 encodes the nuclear enzyme, DEAD-box-type RNA helicase. Mutation of DDX41 leads to hematopoietic cancers.
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63 Physical Biology Of The Cell Rob Phillips Full PDF
https://immunooncology.bms.com/filedownload?article=67109&FileName=Physical%20Biology%20Of%20The%20Cell%20Rob%20Phillips.pdf
and their applications in cell biology, ranging from mitosis, centrioles or nuclear pore complex to plant cell, bacteria, Drosophila or neurons.
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64 Origin T07
https://compass-stg.academia.cl/viewcontent?docid=25816&FileName=Origin%20T07.pdf
nuclear pore complexes and nucleocytoplasmic ... nuclear envelope; and to design in vivo or in vitro ... viral infections, or aging.
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65 Detailed information - CIHR Funding Decisions Database
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=419471&lang=en
› project_details
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66 The Role of AIM2 Inflammasome in Knee Osteoarthritis
https://www.dovepress.com/the-role-of-aim2-inflammasome-in-knee-osteoarthritis-peer-reviewed-fulltext-article-JIR
... in KOA's complex mechanisms in conjunction with the activation of AIM2 ... damaged mitochondria accumulate in the cytoplasm and promote ...
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67 Read Online Ap Biology Chapter 15 Answers Pdf File Free
https://www.museumkesejarahan.jakarta-tourism.go.id/data/space?k=T2F5F9&FileName=Ap_Biology_Chapter_15_Answers
sponsored by the British Society for Research on Ageing, held at the ... mitosis, centrioles or nuclear pore complex to plant cell, bacteria,.
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68 How "Gatekeepers" to a Cell's Nucleus Let Genetic ... - Caltech
https://www.caltech.edu/about/news/how-gatekeepers-cells-nucleus-let-genetic-instructions-pass-through-82466
Researchers have revealed how the human nuclear pore complex is involved in ... protein structures called nuclear pore complexes, or NPCs.
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69 Leica Tcra 1101 Manual Pdf
https://intranet.ulc.edu.pe/IDtrack?docid=77415&FileName=leica%20tcra%201101%20manual.pdf
The volume enables investigators to analyze nuclear pore complex ... aging. The NPC being one of the largest multiprotein complexes in the ...
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70 Click here to download - Computer Science
https://cs.brynmawr.edu/Courses/cs325/fall2013/bigWordList.txt
... east paper single ii age activities club example girls additional password z ... former implementation ten hits zone complex th cat galleries references ...
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71 Molecular Basis of Aging - Page 355 - Google Books Result
https://books.google.com/books?id=FEoPEAAAQBAJ&pg=PA355&lpg=PA355&dq=nuclear+pore+complex+aging&source=bl&ots=N1leRLSO2z&sig=ACfU3U3tHaAeh6dW5eceEMEOtlc1xTJl4g&hl=en&sa=X&ved=2ahUKEwi6gMr7m9n7AhXMCewKHYEBC-oQ6AF6BQiUAhAD
INTRODUCTION The exchange of macromolecules between the nucleus and the cytoplasm occurs across the NE pore complexes. The pore complexes have an octagonal ...
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72 메디투어부산(eng)
https://www.bsmeditour.go.kr/eng/index.do
Skin whitening and Pigmentation, Tatoo, Pores and Scar, Anti-aging, Facial Flushing, Telangiectasia. tell+8151-805-1004. 병원 외부 전경 ...
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73 Cell Biology By C B Powar (PDF)
https://intratest.abastible.cl/fulldisplay?redir_esc=21452&FileName=Cell%20Biology%20By%20C%20B%20Powar.pdf
biology, aging, cell growth, cell Injury, and ... ranging from mitosis, centrioles or nuclear pore complex to plant cell, bacteria,. Drosophila or neurons.
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74 Handbook of the Biology of Aging - Page 146 - Google Books Result
https://books.google.com/books?id=CdKWgqJoX_cC&pg=PA146&lpg=PA146&dq=nuclear+pore+complex+aging&source=bl&ots=wHvo3uvVK6&sig=ACfU3U3Zw4O0iNFNe1gAzd5sl8aRtj6FUA&hl=en&sa=X&ved=2ahUKEwi6gMr7m9n7AhXMCewKHYEBC-oQ6AF6BQiWAhAD
For example, roS were shown to have an adverse effect on the integrity of the nuclear pore complex by oxidizing the subunits that form the transport ...
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75 Nuclear Pore | British Society for Cell Biology
https://bscb.org/learning-resources/softcell-e-learning/nuclear-pore/
The pore complex is constructed from more than one hundred different proteins and is a watery channel that can be as small as 9 nm in diameter. Small water- ...
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76 Cancer Biology and the Nuclear Envelope: Recent Advances May ...
https://books.google.com/books?id=MIm4BAAAQBAJ&pg=PA319&lpg=PA319&dq=nuclear+pore+complex+aging&source=bl&ots=iz3MUi0cij&sig=ACfU3U1JJyVeEF5afjw3tiT4EpzOYyEWBw&hl=en&sa=X&ved=2ahUKEwi6gMr7m9n7AhXMCewKHYEBC-oQ6AF6BQiTAhAD
The premature aging phenotypes induced by the accumulation of pre-lamin A ... D (2001) Kinetic analysis of translocation through nuclear pore complexes.
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77 Biology of Aging - Google Books Result
https://books.google.com/books?id=6wSdDwAAQBAJ&pg=PT282&lpg=PT282&dq=nuclear+pore+complex+aging&source=bl&ots=6sTLQgWUFn&sig=ACfU3U10RoKq78YOx3yVkcFMFr0IG8X-pw&hl=en&sa=X&ved=2ahUKEwi6gMr7m9n7AhXMCewKHYEBC-oQ6AF6BQiVAhAD
recognize only the mRNA and then transport only this molecule out of the nucleus? The nuclear envelope contains openings called nuclear pore complexes ...
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78 Role of PLK1 signaling pathway genes in gastrointestinal ...
https://developers.lokasi.live/jawaban-https-www.academia.edu/50003584/Role_of_PLK1_signaling_pathway_genes_in_gastrointestinal_stromal_tumors?from_sitemaps=true&version=2
... mitotic spindle assembly and in the assembly of nuclear envelope at the exit from mitosis. ... The human cumulus–oocyte complex gene-expression profile.
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79 In Its Greatest Biology Feat Yet, AI Unlocks the Complex ...
https://singularityhub.com/2022/06/14/in-its-greatest-biology-feat-yet-ai-decoded-the-protein-complexes-that-house-our-dna/
Only specific molecules are allowed to enter and leave the cell nucleus. Nuclear pore complexes (NPCs) regulate this traffic.
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