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Google Keyword Rankings for : immune system and beta cells
1
Innate Immunity Mediated Inflammation and Beta Cell ...
https://www.frontiersin.org/articles/10.3389/fendo.2020.606332/full
These cells absolve a crucial role in preserving metabolic homeostasis through cross talk with metabolic tissues in the peripheral system.
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https://www.frontiersin.org/articles/10.3389/fendo.2020.606332/full
These cells absolve a crucial role in preserving metabolic homeostasis through cross talk with metabolic tissues in the peripheral system.
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2
Innate Immunity Mediated Inflammation and Beta Cell Function
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897669/
In fact, T cells are not the only players with an active role in beta cell destruction. Macrophages and neutrophils, which physiologically ...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897669/
In fact, T cells are not the only players with an active role in beta cell destruction. Macrophages and neutrophils, which physiologically ...
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3
Penn Study Uncovers How Pancreatic Cells Reprogram ...
https://www.pennmedicine.org/news/news-releases/2022/february/penn-study-uncovers-how-pancreatic-cells-reprogram-themselves-to-limit-the-immune-response
Penn Study Uncovers How Pancreatic Cells Reprogram Themselves to Limit the Immune Response in Patients at Risk for Type 1 Diabetes.
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https://www.pennmedicine.org/news/news-releases/2022/february/penn-study-uncovers-how-pancreatic-cells-reprogram-themselves-to-limit-the-immune-response
Penn Study Uncovers How Pancreatic Cells Reprogram Themselves to Limit the Immune Response in Patients at Risk for Type 1 Diabetes.
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4
β-Cells, Autoimmunity, and the Innate Immune System
https://diabetesjournals.org/diabetes/article/62/6/1821/15818/Cells-Autoimmunity-and-the-Innate-Immune-System-un
Interactions between β-cells, the innate immune system, and the adaptive immune system. Autoreactive T cells and islet autoantibodies can ...
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https://diabetesjournals.org/diabetes/article/62/6/1821/15818/Cells-Autoimmunity-and-the-Innate-Immune-System-un
Interactions between β-cells, the innate immune system, and the adaptive immune system. Autoreactive T cells and islet autoantibodies can ...
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5
Type 1 diabetes mellitus as a disease of the β-cell (do ... - Nature
https://www.nature.com/articles/s41574-020-00443-4
a | In healthy individuals, β-cells are protected from autoimmune β-cell destruction by immune regulation exerted by regulatory T (Treg) cells ...
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https://www.nature.com/articles/s41574-020-00443-4
a | In healthy individuals, β-cells are protected from autoimmune β-cell destruction by immune regulation exerted by regulatory T (Treg) cells ...
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6
Protecting beta cells against type 1 diabetes
https://hsci.harvard.edu/news/protecting-beta-cells-against-type-1-diabetes
The investigators checked to see if the cells that lacked the renalase gene provoked a diminished response from T immune cells, which are responsible for ...
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https://hsci.harvard.edu/news/protecting-beta-cells-against-type-1-diabetes
The investigators checked to see if the cells that lacked the renalase gene provoked a diminished response from T immune cells, which are responsible for ...
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7
Definition: Beta Cells (for Parents) - Nemours KidsHealth
https://kidshealth.org/en/parents/beta-cells.html
Beta cells are found in the pancreas within clusters of cells known as islets. In type 1 diabetes, the body's immune system mistakenly destroys the beta cells.
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https://kidshealth.org/en/parents/beta-cells.html
Beta cells are found in the pancreas within clusters of cells known as islets. In type 1 diabetes, the body's immune system mistakenly destroys the beta cells.
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8
Breaking and restoring immune tolerance to pancreatic beta-c...
https://journals.lww.com/co-endocrinology/fulltext/2021/08000/breaking_and_restoring_immune_tolerance_to.11.aspx
The role of beta-cells and islets themselves in dialogue with their micro- and macro-environment including the immune system and the intestinal microbiome ...
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https://journals.lww.com/co-endocrinology/fulltext/2021/08000/breaking_and_restoring_immune_tolerance_to.11.aspx
The role of beta-cells and islets themselves in dialogue with their micro- and macro-environment including the immune system and the intestinal microbiome ...
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9
Towards effective beta-cell replacement through ...
https://www.sciencedirect.com/science/article/pii/S2468498821000202
Fig. 1. The four main concepts for immune-shielding and immunosuppression following transplantation of beta cells. Micro- and microencapsulation provides a ...
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https://www.sciencedirect.com/science/article/pii/S2468498821000202
Fig. 1. The four main concepts for immune-shielding and immunosuppression following transplantation of beta cells. Micro- and microencapsulation provides a ...
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10
Device Protects Transplanted Pancreatic Cells from the ...
https://health.ucsd.edu/news/2009/pages/4-8-transplanted-pancreatic-cells.aspx
Type 1 diabetes results from an autoimmune response wherein the body attacks and kills insulin-producing beta cells in the pancreas. One of the challenges of ...
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https://health.ucsd.edu/news/2009/pages/4-8-transplanted-pancreatic-cells.aspx
Type 1 diabetes results from an autoimmune response wherein the body attacks and kills insulin-producing beta cells in the pancreas. One of the challenges of ...
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11
Understanding Type 1 Diabetes - Stanford Children's Health
https://www.stanfordchildrens.org/en/topic/default?id=understanding-type-1-diabetes-138-V1042
With type 1 diabetes, your immune system attacks your insulin-producing beta-cells. Without these beta-cells, your body doesn't have enough insulin.
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https://www.stanfordchildrens.org/en/topic/default?id=understanding-type-1-diabetes-138-V1042
With type 1 diabetes, your immune system attacks your insulin-producing beta-cells. Without these beta-cells, your body doesn't have enough insulin.
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12
T cells, B cells and the immune system
https://www.mdanderson.org/cancerwise/t-cells--b-cells-and-the-immune-system.h00-159465579.html
B cells create antibodies. B lymphocytes, also called B cells, create a type of protein called an antibody. These antibodies bind to pathogens ...
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https://www.mdanderson.org/cancerwise/t-cells--b-cells-and-the-immune-system.h00-159465579.html
B cells create antibodies. B lymphocytes, also called B cells, create a type of protein called an antibody. These antibodies bind to pathogens ...
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13
Interactions between islets and regulatory immune cells in ...
https://link.springer.com/article/10.1007/s00125-021-05565-6
Type 1 diabetes results from defects in immune self-tolerance that lead to inflammatory infiltrate in pancreatic islets, beta cell ...
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https://link.springer.com/article/10.1007/s00125-021-05565-6
Type 1 diabetes results from defects in immune self-tolerance that lead to inflammatory infiltrate in pancreatic islets, beta cell ...
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14
Intervening in Beta Cell-Immune System Dialogue Could ...
https://www.genengnews.com/topics/drug-discovery/intervening-in-beta-cell-immune-system-dialogue-could-prevent-diabetes-study-suggests/
More recently, it's been suggested that it might be the beta cells that represent the “center of a dialogue with immune cells,” such that ...
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https://www.genengnews.com/topics/drug-discovery/intervening-in-beta-cell-immune-system-dialogue-could-prevent-diabetes-study-suggests/
More recently, it's been suggested that it might be the beta cells that represent the “center of a dialogue with immune cells,” such that ...
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15
Type 1 diabetes and the immune system: scientists uncover ...
https://www.diamond.ac.uk/Home/News/LatestNews/2016/17-05-16.html
“During type 1 diabetes, killer T-cells are thought to attack pancreatic beta cells. These cells make the insulin that is essential for control of blood sugar ...
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https://www.diamond.ac.uk/Home/News/LatestNews/2016/17-05-16.html
“During type 1 diabetes, killer T-cells are thought to attack pancreatic beta cells. These cells make the insulin that is essential for control of blood sugar ...
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16
Autoimmunity - Diabetes Education Online
https://dtc.ucsf.edu/types-of-diabetes/type1/understanding-type-1-diabetes/autoimmunity/
If the immune system mistakenly identifies beta cells, the resulting absence of insulin leads to a diagnosis of diabetes. Type 1a diabetes develops because ...
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https://dtc.ucsf.edu/types-of-diabetes/type1/understanding-type-1-diabetes/autoimmunity/
If the immune system mistakenly identifies beta cells, the resulting absence of insulin leads to a diagnosis of diabetes. Type 1a diabetes develops because ...
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17
Beta Cells - What They Do, Role in Insulin - Diabetes UK
https://www.diabetes.co.uk/body/beta-cells.html
In type 1 diabetes, beta cells die from a misguided attack by the body's immune system How and why that happens is not clear, but the results of a study ...
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https://www.diabetes.co.uk/body/beta-cells.html
In type 1 diabetes, beta cells die from a misguided attack by the body's immune system How and why that happens is not clear, but the results of a study ...
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18
Retraining the immune system may hold key to diabetes ...
https://ec.europa.eu/research-and-innovation/en/horizon-magazine/retraining-immune-system-may-hold-key-diabetes-prevention
Type 1 diabetes is an autoimmune disease, meaning the body's defence mechanisms mistakenly attack its own cells and organs. In this case, the immune system ...
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https://ec.europa.eu/research-and-innovation/en/horizon-magazine/retraining-immune-system-may-hold-key-diabetes-prevention
Type 1 diabetes is an autoimmune disease, meaning the body's defence mechanisms mistakenly attack its own cells and organs. In this case, the immune system ...
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19
Immune interventions to preserve β cell function in type 1 ...
https://jim.bmj.com/content/64/1/7
Type 1 diabetes immunopathology and targets for immune intervention. Type 1 diabetes is a T-cell–mediated autoimmune process in which islet antigens are ...
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https://jim.bmj.com/content/64/1/7
Type 1 diabetes immunopathology and targets for immune intervention. Type 1 diabetes is a T-cell–mediated autoimmune process in which islet antigens are ...
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20
Type 1 diabetes | WEHI
https://www.wehi.edu.au/research-diseases/immune-health-and-infection/type-1-diabetes
Type 1 diabetes occurs when the immune system attacks and destroys the beta cells in the pancreas that produce the hormone insulin.
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https://www.wehi.edu.au/research-diseases/immune-health-and-infection/type-1-diabetes
Type 1 diabetes occurs when the immune system attacks and destroys the beta cells in the pancreas that produce the hormone insulin.
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21
Keeping immune cells in check to ward off diabetes
https://www.advancedsciencenews.com/keeping-immune-cells-in-check-to-ward-off-diabetes/
Researchers have shown they can avert the immune destruction of pancreatic beta cells and potentially halt the progression of type 1 ...
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https://www.advancedsciencenews.com/keeping-immune-cells-in-check-to-ward-off-diabetes/
Researchers have shown they can avert the immune destruction of pancreatic beta cells and potentially halt the progression of type 1 ...
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22
Immune cells drive beta cell loss in Type 2 diabetes
https://news.vumc.org/2022/09/08/immune-cells-beta-cell-loss-type2diabetes/
Wenbiao Chen, PhD, and colleagues previously have shown that overnutrition stressed the endoplasmic reticulum, the part of the beta cell ...
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https://news.vumc.org/2022/09/08/immune-cells-beta-cell-loss-type2diabetes/
Wenbiao Chen, PhD, and colleagues previously have shown that overnutrition stressed the endoplasmic reticulum, the part of the beta cell ...
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23
B Cells | British Society for Immunology
https://www.immunology.org/public-information/bitesized-immunology/cells/b-cells
B cells are at the centre of the adaptive humoral immune system and are responsible for mediating the production of antigen-specific immunoglobulin (Ig) ...
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https://www.immunology.org/public-information/bitesized-immunology/cells/b-cells
B cells are at the centre of the adaptive humoral immune system and are responsible for mediating the production of antigen-specific immunoglobulin (Ig) ...
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24
B cell - Wikipedia
https://en.wikipedia.org/wiki/B_cell
They function in the humoral immunity component of the adaptive immune system. ... B cells produce antibody molecules which may be either secreted or inserted ...
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https://en.wikipedia.org/wiki/B_cell
They function in the humoral immunity component of the adaptive immune system. ... B cells produce antibody molecules which may be either secreted or inserted ...
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25
Resetting the immune system to cure diabetes and rheumatism
https://www.universiteitleiden.nl/en/research-dossiers/immunity-infection-and-tolerance/resetting-the-immune-system-to-cure-diabetes-and-rheumatism
With diabetes the immune system destroys the insulin-producing beta cells in the pancreas. 'To date treatment is only about managing the symptoms.
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https://www.universiteitleiden.nl/en/research-dossiers/immunity-infection-and-tolerance/resetting-the-immune-system-to-cure-diabetes-and-rheumatism
With diabetes the immune system destroys the insulin-producing beta cells in the pancreas. 'To date treatment is only about managing the symptoms.
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26
Immune Interventions to Preserve Beta Cell Function in Type 1 ...
https://www.immunetolerance.org/sites/default/files/Ehlers%20-%20J%20Investig%20Med%202016.pdf
Type 1 diabetes (T1D) is a chronic autoimmune disease that leads to destruction of pancreatic beta cells, lifelong dependence on insulin, and increased ...
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https://www.immunetolerance.org/sites/default/files/Ehlers%20-%20J%20Investig%20Med%202016.pdf
Type 1 diabetes (T1D) is a chronic autoimmune disease that leads to destruction of pancreatic beta cells, lifelong dependence on insulin, and increased ...
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27
Immune Modulation - City of Hope
https://www.cityofhope.org/research/riggs-institute/wanek-project/wanek-project-research/immune-modulation
Our innovative approaches aim to restore a balanced immune system in order to stop its attack on insulin-producing beta cells. We are also endeavoring to ...
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https://www.cityofhope.org/research/riggs-institute/wanek-project/wanek-project-research/immune-modulation
Our innovative approaches aim to restore a balanced immune system in order to stop its attack on insulin-producing beta cells. We are also endeavoring to ...
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28
“Why the Immune System Kills Beta but not Alpha Cells” - HIRN
https://hirnetwork.org/news/webinar-may2022
Webinar: “Why the Immune System Kills Beta but not Alpha Cells” · Alpha-cells are dysfunctional but not killed in type 1 diabetes · Are there ...
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https://hirnetwork.org/news/webinar-may2022
Webinar: “Why the Immune System Kills Beta but not Alpha Cells” · Alpha-cells are dysfunctional but not killed in type 1 diabetes · Are there ...
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29
Webinar: Why the Immune System Kills Beta but not Alpha Cells
https://www.youtube.com/watch?v=rMxlv3TlMzs
Human Islet Research Network
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https://www.youtube.com/watch?v=rMxlv3TlMzs
Human Islet Research Network
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30
Mechanisms of Beta-Cell Death in Type 1 Diabetes
https://www.mines.edu/undergraduate-research/mechanisms-of-beta-cell-death-in-type-1-diabetes/
Type 1 diabetes (T1D) is characterized by a progressive loss of insulin-producing β-cells in pancreatic islets. The immune destruction of β-cells is partly ...
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https://www.mines.edu/undergraduate-research/mechanisms-of-beta-cell-death-in-type-1-diabetes/
Type 1 diabetes (T1D) is characterized by a progressive loss of insulin-producing β-cells in pancreatic islets. The immune destruction of β-cells is partly ...
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31
Novel Immune Strategies to Enhance Beta Cell Replacement ...
https://grantcenter.jdrf.org/rfa/novel-immune-strategies-to-enhance-beta-cell-replacement-therapies-for-t1d/
The reliance on systemic administration of immunosuppressive drugs to protect the cell graft from the recipient's immune response is one key limitation ...
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https://grantcenter.jdrf.org/rfa/novel-immune-strategies-to-enhance-beta-cell-replacement-therapies-for-t1d/
The reliance on systemic administration of immunosuppressive drugs to protect the cell graft from the recipient's immune response is one key limitation ...
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32
Why does type 1 diabetes kill some cells but not others?
https://www.medicalnewstoday.com/articles/315735
Type 1 diabetes is an autoimmune disease. The body does not recognize its own insulin-producing beta cellsTrusted Source , so the immune system ...
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https://www.medicalnewstoday.com/articles/315735
Type 1 diabetes is an autoimmune disease. The body does not recognize its own insulin-producing beta cellsTrusted Source , so the immune system ...
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33
Our research finds new players in the type 1 diabetes immune ...
https://www.diabetes.org.uk/about_us/news/research-finds-new-players-type-1-diabetes-immune-attack
The immune system's A B Cs ... One type of immune cell involved in the immune attack on the pancreas is called a B cell. In type 1 diabetes, B ...
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https://www.diabetes.org.uk/about_us/news/research-finds-new-players-type-1-diabetes-immune-attack
The immune system's A B Cs ... One type of immune cell involved in the immune attack on the pancreas is called a B cell. In type 1 diabetes, B ...
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34
Type 1 diabetes from a beta cell's perspective
https://wi.mit.edu/news/type-1-diabetes-beta-cell-s-perspective
Type 1 diabetes is an autoimmune disease that occurs when T-cells in the immune system attack the body's own insulin-producing cells, ...
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https://wi.mit.edu/news/type-1-diabetes-beta-cell-s-perspective
Type 1 diabetes is an autoimmune disease that occurs when T-cells in the immune system attack the body's own insulin-producing cells, ...
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35
B-Cells vs T-Cells: Learn the Difference & Types of T-Cells
https://www.cancercenter.com/what-are-b-cells-vs-t-cells
B-cells are the type of cells that produce antibodies to fight bacteria and viruses. These antibodies are Y-shaped proteins that are specific to each pathogen ...
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https://www.cancercenter.com/what-are-b-cells-vs-t-cells
B-cells are the type of cells that produce antibodies to fight bacteria and viruses. These antibodies are Y-shaped proteins that are specific to each pathogen ...
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36
Autoimmune Destruction of Pancreatic b Cells
http://www.columbia.edu/itc/hs/medical/pathophys/immunology/readings/IsetCellDestructionReview.pdf
system. These autoreactive CD4+ T cells are activated and secrete cytokines, which can ... Pancreatic b cell autoantigens are the targets of immune-.
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http://www.columbia.edu/itc/hs/medical/pathophys/immunology/readings/IsetCellDestructionReview.pdf
system. These autoreactive CD4+ T cells are activated and secrete cytokines, which can ... Pancreatic b cell autoantigens are the targets of immune-.
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37
Researchers discover how pancreatic cells remodel ...
https://www.azolifesciences.com/news/20220302/Researchers-discover-how-pancreatic-cells-remodel-themselves-to-reduce-the-immune-response-in-patients-at-risk-for-T1D.aspx
T lymphocytes target and damage insulin-secreting pancreatic beta cells in T1D, resulting in the pancreas ceasing to produce insulin—the hormone ...
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https://www.azolifesciences.com/news/20220302/Researchers-discover-how-pancreatic-cells-remodel-themselves-to-reduce-the-immune-response-in-patients-at-risk-for-T1D.aspx
T lymphocytes target and damage insulin-secreting pancreatic beta cells in T1D, resulting in the pancreas ceasing to produce insulin—the hormone ...
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38
B-Cells in Your Immune System Help Fight Off Infections
https://www.verywellhealth.com/b-cells-2252132
The primary responsibility of B-cells involves the body's response to foreign invaders through what is known as humoral immunity.
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https://www.verywellhealth.com/b-cells-2252132
The primary responsibility of B-cells involves the body's response to foreign invaders through what is known as humoral immunity.
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39
Protecting beta cells from the immune system - JDRF UK
https://jdrf.org.uk/research_projects/protecting-beta-cells-from-the-immune-system/
In type 1 diabetes, the immune system mistakenly attacks and destroys beta cells, which produce insulin. Dr Bewick is exploring ways to improve the health, ...
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https://jdrf.org.uk/research_projects/protecting-beta-cells-from-the-immune-system/
In type 1 diabetes, the immune system mistakenly attacks and destroys beta cells, which produce insulin. Dr Bewick is exploring ways to improve the health, ...
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40
Islet–immune interactions in type 1 ... - Wiley Online Library
https://onlinelibrary.wiley.com/doi/full/10.1111/cei.13349
GABA receptors are also expressed on immune cells 100, and GABA was recently demonstrated to function in an immunoregulatory capacity, ...
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https://onlinelibrary.wiley.com/doi/full/10.1111/cei.13349
GABA receptors are also expressed on immune cells 100, and GABA was recently demonstrated to function in an immunoregulatory capacity, ...
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41
Islet Regeneration - Center for Regenerative Biotherapeutics
https://www.mayo.edu/research/centers-programs/center-regenerative-biotherapeutics/focus-areas/islet-regeneration
Glucose-responsive, insulin-secreting cells in the islets (beta cells) are dysfunctional in both type 1 and type 2 diabetes. In type 1 diabetes, beta cells are ...
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https://www.mayo.edu/research/centers-programs/center-regenerative-biotherapeutics/focus-areas/islet-regeneration
Glucose-responsive, insulin-secreting cells in the islets (beta cells) are dysfunctional in both type 1 and type 2 diabetes. In type 1 diabetes, beta cells are ...
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42
Type 1 diabetes: MedlinePlus Medical Encyclopedia
https://medlineplus.gov/ency/article/000305.htm
With type 1 diabetes, an infection or another trigger causes the body to mistakenly attack the beta cells in the pancreas that make insulin. The ...
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https://medlineplus.gov/ency/article/000305.htm
With type 1 diabetes, an infection or another trigger causes the body to mistakenly attack the beta cells in the pancreas that make insulin. The ...
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43
Could beta cells be the source of Type 1 diabetes after all?
https://www.fiercebiotech.com/biotech/new-study-adds-growing-evidence-immune-system-may-not-be-source-type-1-diabetes-after-all
A new study suggests the source of Type 1 diabetes may not in fact be the immune system, but rather beta cells themselves.
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https://www.fiercebiotech.com/biotech/new-study-adds-growing-evidence-immune-system-may-not-be-source-type-1-diabetes-after-all
A new study suggests the source of Type 1 diabetes may not in fact be the immune system, but rather beta cells themselves.
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44
T1D Facts | TRIALNET Type 1 Diabetes TrialNet
https://www.trialnet.org/t1d-facts
During the immune activation and immune response involved in T1D, the immune system mistakenly attacks cells in the pancreas (immune activation), leading to the ...
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https://www.trialnet.org/t1d-facts
During the immune activation and immune response involved in T1D, the immune system mistakenly attacks cells in the pancreas (immune activation), leading to the ...
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45
Beta Cell-Immune Cell Crosstalk — EnginLab
https://www.enginlab.org/beta-cell-immune-cell-crosstalk-in-type-1-diabetes
β-cell endoplasmic reticulum (ER) stress may influence immune cell activation and function in the pancreas through a multitude of mechanisms.
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https://www.enginlab.org/beta-cell-immune-cell-crosstalk-in-type-1-diabetes
β-cell endoplasmic reticulum (ER) stress may influence immune cell activation and function in the pancreas through a multitude of mechanisms.
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46
Exploring Why the Immune System May Attack Insulin ...
https://diabetesresearchconnection.org/exploring-why-the-immune-system-may-attack-insulin-producing-beta-cells/
Insulin-producing beta cells are essential for effective blood sugar control. However, in individuals with type 1 diabetes, these cells are ...
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https://diabetesresearchconnection.org/exploring-why-the-immune-system-may-attack-insulin-producing-beta-cells/
Insulin-producing beta cells are essential for effective blood sugar control. However, in individuals with type 1 diabetes, these cells are ...
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47
Sustain - DRIF - Diabetes Research Institute
https://diabetesresearch.org/sustain/
Promote beta-cell health: strengthening the beta cell. Regulating the Immune System. Traditional immunosuppressive drugs deliberately reduce the activation of ...
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https://diabetesresearch.org/sustain/
Promote beta-cell health: strengthening the beta cell. Regulating the Immune System. Traditional immunosuppressive drugs deliberately reduce the activation of ...
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48
Inflammatory Beta-cell Destruction in Diabetes - Part 2, by ...
https://www.coursera.org/lecture/diabetes/inflammatory-beta-cell-destruction-in-diabetes-part-2-by-professor-thomas-oqQg4
[MUSIC] Let us now first consider how inflammatory beta cell destruction comes about in Type 1 diabetes. To understand how the immune system accomplishes ...
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https://www.coursera.org/lecture/diabetes/inflammatory-beta-cell-destruction-in-diabetes-part-2-by-professor-thomas-oqQg4
[MUSIC] Let us now first consider how inflammatory beta cell destruction comes about in Type 1 diabetes. To understand how the immune system accomplishes ...
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49
Immune Overhaul for Diabetes - MIT Technology Review
https://www.technologyreview.com/2009/04/14/214246/immune-overhaul-for-diabetes/
A stem-cell transplant would only be effective in newly diagnosed patients who still have some beta cells left to preserve. Some patients have ...
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https://www.technologyreview.com/2009/04/14/214246/immune-overhaul-for-diabetes/
A stem-cell transplant would only be effective in newly diagnosed patients who still have some beta cells left to preserve. Some patients have ...
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50
GABA exerts protective and regenerative effects on islet beta ...
https://www.pnas.org/doi/10.1073/pnas.1102715108
We report here that GABA exerts antidiabetic effects by acting on both the islet β-cells and immune system. Unlike in adult brain or islet ...
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https://www.pnas.org/doi/10.1073/pnas.1102715108
We report here that GABA exerts antidiabetic effects by acting on both the islet β-cells and immune system. Unlike in adult brain or islet ...
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51
New research gets to the roots of type 1 diabetes
https://www.lji.org/blog/new-research-gets-to-the-roots-of-type-1-diabetes/
Healthy beta cells in the pancreas can talk to the immune system by displaying special markers—little molecular flags—to tell other cells ...
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https://www.lji.org/blog/new-research-gets-to-the-roots-of-type-1-diabetes/
Healthy beta cells in the pancreas can talk to the immune system by displaying special markers—little molecular flags—to tell other cells ...
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52
Mediators and Mechanisms of Pancreatic Beta-cell ... - SciELO
https://www.scielo.br/j/abem/a/3yJDQ8KBFnyxX4rB94jqBTj/?lang=en&format=pdf
resulting from chronic and progressive destruction of pancreatic beta-cells by the immune system. the triggering of autoimmunity against the beta-cells is.
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https://www.scielo.br/j/abem/a/3yJDQ8KBFnyxX4rB94jqBTj/?lang=en&format=pdf
resulting from chronic and progressive destruction of pancreatic beta-cells by the immune system. the triggering of autoimmunity against the beta-cells is.
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53
Immune Checkpoint Inhibitor-Induced Diabetes Mellitus - MDPI
https://www.mdpi.com/1422-0067/22/4/2093/htm
This could be explained by the fact that the upregulation of PD-L1 expression in insulin-producing β cells may be a protective response to limit ...
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https://www.mdpi.com/1422-0067/22/4/2093/htm
This could be explained by the fact that the upregulation of PD-L1 expression in insulin-producing β cells may be a protective response to limit ...
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54
The Impact of Inflammation on Pancreatic β-Cell Metabolism ...
https://www.intechopen.com/chapters/43296
4. Immune-like characteristics of β-cells and response to cytokines. The pathophysiology of pancreatic islets in T1 and T2DM is characterised by an inflammatory ...
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https://www.intechopen.com/chapters/43296
4. Immune-like characteristics of β-cells and response to cytokines. The pathophysiology of pancreatic islets in T1 and T2DM is characterised by an inflammatory ...
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55
First immune-evading cells created to treat type 1 diabetes
https://www.salk.edu/news-release/first-immune-evading-cells-created-to-treat-type-1-diabetes/
Using stem cell technology, Salk researchers generated the first human insulin-producing pancreatic cell clusters able to evade the immune ...
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https://www.salk.edu/news-release/first-immune-evading-cells-created-to-treat-type-1-diabetes/
Using stem cell technology, Salk researchers generated the first human insulin-producing pancreatic cell clusters able to evade the immune ...
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56
Beta Cells - Diabetes Resources & Information
https://www.diabetesselfmanagement.com/diabetes-resources/definitions/beta-cells/
The cells located within the islets of Langerhans of the pancreas that secrete insulin. The process leading to Type 1 (insulin-dependent) ...
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https://www.diabetesselfmanagement.com/diabetes-resources/definitions/beta-cells/
The cells located within the islets of Langerhans of the pancreas that secrete insulin. The process leading to Type 1 (insulin-dependent) ...
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57
Swapping alpha cells for beta cells to treat diabetes
https://www.utsouthwestern.edu/newsroom/articles/year-2021/beta-cells-diabetes.html
In Type 2 diabetes, the body's tissues develop insulin resistance, prompting beta cells to die from exhaustion from secreting excess insulin to ...
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https://www.utsouthwestern.edu/newsroom/articles/year-2021/beta-cells-diabetes.html
In Type 2 diabetes, the body's tissues develop insulin resistance, prompting beta cells to die from exhaustion from secreting excess insulin to ...
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58
Effect of AC2993 With or Without Immunosuppression on Beta ...
https://clinicaltrials.gov/ct2/show/NCT00064714
Type I diabetes is an autoimmune disease, in which the immune system attacks the beta cells of the pancreas. These cells produce insulin, which regulates ...
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https://clinicaltrials.gov/ct2/show/NCT00064714
Type I diabetes is an autoimmune disease, in which the immune system attacks the beta cells of the pancreas. These cells produce insulin, which regulates ...
→ Check Latest Keyword Rankings ←
59
How Immunotherapy Could Stop and Prevent Type 1 Diabetes
https://www.labiotech.eu/in-depth/immunotherapy-type-1-diabetes/
“In type 1 diabetes, cells in the immune system wrongly recognize the insulin-producing cells in the pancreas as foreign and dangerous,” said ...
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https://www.labiotech.eu/in-depth/immunotherapy-type-1-diabetes/
“In type 1 diabetes, cells in the immune system wrongly recognize the insulin-producing cells in the pancreas as foreign and dangerous,” said ...
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60
Long-Sought 'Attack' Signal in Type 1 Diabetes Identified
https://www.livescience.com/57323-autoimmune-trigger-in-type-1-diabetes-identified.html
It's possible that inflammation, such as the response to an infection or other assault, stresses the beta cells and causes them to release ...
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https://www.livescience.com/57323-autoimmune-trigger-in-type-1-diabetes-identified.html
It's possible that inflammation, such as the response to an infection or other assault, stresses the beta cells and causes them to release ...
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61
β Cell in Diabetes: Integrating Biomarkers With Functional ...
https://academic.oup.com/edrv/article/42/5/528/6310678
In type 1 diabetes, β-cell loss through autoimmune attack is an important contributor to the secretory function defect. On the other hand, in type 2 diabetes, ...
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https://academic.oup.com/edrv/article/42/5/528/6310678
In type 1 diabetes, β-cell loss through autoimmune attack is an important contributor to the secretory function defect. On the other hand, in type 2 diabetes, ...
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62
'Retraining' the immune system - News - Cardiff University
https://www.cardiff.ac.uk/news/view/881109-retraining-the-immune-system
Type 1 diabetes develops when a patient's immune system mistakenly attacks the insulin producing beta cells in the pancreas.
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https://www.cardiff.ac.uk/news/view/881109-retraining-the-immune-system
Type 1 diabetes develops when a patient's immune system mistakenly attacks the insulin producing beta cells in the pancreas.
→ Check Latest Keyword Rankings ←
63
Development of immune invisible beta cells as a cell therapy ...
https://www.cirm.ca.gov/our-progress/awards/development-immune-invisible-beta-cells-cell-therapy-type-1-diabetes-through
To reconstitute immunodeficient mice with human immune system, denoted Hu-mice. To test whether CTLA4-Ig/PD-L1(CP)-expressing pancreatic β-cell precursors ...
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https://www.cirm.ca.gov/our-progress/awards/development-immune-invisible-beta-cells-cell-therapy-type-1-diabetes-through
To reconstitute immunodeficient mice with human immune system, denoted Hu-mice. To test whether CTLA4-Ig/PD-L1(CP)-expressing pancreatic β-cell precursors ...
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64
Type 1 Diabetes not to be blamed on the immune system
https://www.lumc.nl/over-het-lumc/nieuws/2017/februari/diabetes-type-1-is-niet-een-vergissing-van-het-afweersysteem/?setlanguage=English
LUMC researchers have now discovered that the immune system often responds to an incorrect protein that beta cells sometimes produce instead of ...
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https://www.lumc.nl/over-het-lumc/nieuws/2017/februari/diabetes-type-1-is-niet-een-vergissing-van-het-afweersysteem/?setlanguage=English
LUMC researchers have now discovered that the immune system often responds to an incorrect protein that beta cells sometimes produce instead of ...
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65
Vitamin D supplementation induces CatG-mediated CD4 + T ...
https://journals.physiology.org/doi/full/10.1152/ajpendo.00066.2021
Type 1 diabetes (T1D) is a chronic autoimmune disease accompanied by the immune-mediated destruction of pancreatic β-cells.
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https://journals.physiology.org/doi/full/10.1152/ajpendo.00066.2021
Type 1 diabetes (T1D) is a chronic autoimmune disease accompanied by the immune-mediated destruction of pancreatic β-cells.
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66
Virus-like infection induces human β cell dedifferentiation
https://insight.jci.org/articles/view/97732
Furthermore, mechanisms involved in the alteration of human β cell function following viral infection are unknown. For example, recent data ...
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https://insight.jci.org/articles/view/97732
Furthermore, mechanisms involved in the alteration of human β cell function following viral infection are unknown. For example, recent data ...
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67
Coronavirus takes aim at insulin-producing cells in the pancreas
https://scopeblog.stanford.edu/2021/06/15/coronavirus-takes-aim-at-insulin-producing-cells-in-the-pancreas/
The loss of these pancreatic cells, known as beta cells, is the defining feature of type 1 diabetes, understood to be triggered when the body's ...
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https://scopeblog.stanford.edu/2021/06/15/coronavirus-takes-aim-at-insulin-producing-cells-in-the-pancreas/
The loss of these pancreatic cells, known as beta cells, is the defining feature of type 1 diabetes, understood to be triggered when the body's ...
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68
A Nanovaccine That Stops Autoimmune Disease by Boosting ...
https://www.scientificamerican.com/article/nanovaccine-for-autoimmune-disease/
Therapies that suppress the immune system carry the risk of letting ... other cells (like invaders or, in the case of diabetes, beta cells), ...
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https://www.scientificamerican.com/article/nanovaccine-for-autoimmune-disease/
Therapies that suppress the immune system carry the risk of letting ... other cells (like invaders or, in the case of diabetes, beta cells), ...
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69
Artificial intelligence identifies a new drug for beta cell ... - IGTP
https://www.germanstrias.org/en/news/207/artificial-intelligence-identifies-a-new-drug-for-beta-cell-regeneration-in-type-1-diabetes
In T1D, the immune system destroys the insulin-producing beta cells in the islets of the pancreas. Insulin is a hormone that controls blood ...
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https://www.germanstrias.org/en/news/207/artificial-intelligence-identifies-a-new-drug-for-beta-cell-regeneration-in-type-1-diabetes
In T1D, the immune system destroys the insulin-producing beta cells in the islets of the pancreas. Insulin is a hormone that controls blood ...
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70
Innate Immunity, Toll-Like Receptors, and Diabetes
https://www.utoledo.edu/med/depts/medicine/endocrinology/research/ceder/pdfs/Mclnerney%20AlexanderInnate%20immunity%20TLR%20and%20Diabetes.pdf
Type 1 diabetes (T1D) is an autoimmune disease wherein the immune system specifically targets the destruction of pancreatic insulin producing -cells.
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https://www.utoledo.edu/med/depts/medicine/endocrinology/research/ceder/pdfs/Mclnerney%20AlexanderInnate%20immunity%20TLR%20and%20Diabetes.pdf
Type 1 diabetes (T1D) is an autoimmune disease wherein the immune system specifically targets the destruction of pancreatic insulin producing -cells.
→ Check Latest Keyword Rankings ←
71
The Role of Inflammation in Diabetes: Current Concepts and ...
https://www.ecrjournal.com/articles/role-inflammation-diabetes-current-concepts-and-future-perspectives
The role of obesity, adipose tissue, gut microbiota and pancreatic beta cell function in diabetes are under intensive scrutiny with several ...
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https://www.ecrjournal.com/articles/role-inflammation-diabetes-current-concepts-and-future-perspectives
The role of obesity, adipose tissue, gut microbiota and pancreatic beta cell function in diabetes are under intensive scrutiny with several ...
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72
Immunotherapy explained - SVI
https://www.svi.edu.au/news/immunotherapy_explained
“Type 1 diabetes occurs when the immune system mistakenly begins destroying a person's own beta cells in the pancreas, as if they were a ...
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https://www.svi.edu.au/news/immunotherapy_explained
“Type 1 diabetes occurs when the immune system mistakenly begins destroying a person's own beta cells in the pancreas, as if they were a ...
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73
Beta Cell Dysfunction - Diabetes and the Environment
https://www.diabetesandenvironment.org/home/potential-mechanisms/beta-cell-dysfunction
It worked-- the stressed beta cells did cause an increased immune response (Marré et al. 2016). Researchers are now looking into the mechanisms by which beta ...
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https://www.diabetesandenvironment.org/home/potential-mechanisms/beta-cell-dysfunction
It worked-- the stressed beta cells did cause an increased immune response (Marré et al. 2016). Researchers are now looking into the mechanisms by which beta ...
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74
Under the Microscope - Type 1 Diabetes
https://pathology.jhu.edu/type1-diabetes/under-the-microscope
2) These APCs travel to the lymph nodes and other parts of the body where to they involved in priming other parts of the immune system such as B Cells and T ...
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https://pathology.jhu.edu/type1-diabetes/under-the-microscope
2) These APCs travel to the lymph nodes and other parts of the body where to they involved in priming other parts of the immune system such as B Cells and T ...
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75
Tiny implant cures diabetes in mice without triggering immune ...
https://medicine.wustl.edu/news/tiny-implant-cures-diabetes-in-mice-without-triggering-immune-response/
“The problem is that in people with Type 1 diabetes, the immune system attacks those insulin-secreting cells and destroys them. To deliver those ...
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https://medicine.wustl.edu/news/tiny-implant-cures-diabetes-in-mice-without-triggering-immune-response/
“The problem is that in people with Type 1 diabetes, the immune system attacks those insulin-secreting cells and destroys them. To deliver those ...
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76
Type 1 Diabetes Causes - EndocrineWeb
https://www.endocrineweb.com/conditions/type-1-diabetes/type-1-diabetes-causes
The T cell products (antibodies) can destroy the beta cells, and once all the beta cells in your body have been destroyed, you can't produce enough insulin. It ...
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https://www.endocrineweb.com/conditions/type-1-diabetes/type-1-diabetes-causes
The T cell products (antibodies) can destroy the beta cells, and once all the beta cells in your body have been destroyed, you can't produce enough insulin. It ...
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77
Components of the Immune System - Healio
https://www.healio.com/hematology-oncology/learn-immuno-oncology/the-immune-system/components-of-the-immune-system
Natural killer T lymphocytes and B lymphocytes are examples of effector cells. For example, activated T lymphocytes destroy pathogens via cell-mediated response ...
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https://www.healio.com/hematology-oncology/learn-immuno-oncology/the-immune-system/components-of-the-immune-system
Natural killer T lymphocytes and B lymphocytes are examples of effector cells. For example, activated T lymphocytes destroy pathogens via cell-mediated response ...
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78
How Can the Body's Immune Cells Cause Type 1 Diabetes?
https://news.cuanschutz.edu/news-stories/how-can-the-bodys-immune-cells-cause-type-1-diabetes
Why do immune cells target the insulin producing cells in the pancreas in type 1 diabetes? Can you talk about B cell activation and “anergy”?
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https://news.cuanschutz.edu/news-stories/how-can-the-bodys-immune-cells-cause-type-1-diabetes
Why do immune cells target the insulin producing cells in the pancreas in type 1 diabetes? Can you talk about B cell activation and “anergy”?
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79
Islet–immune interactions in type 1 diabetes: the ... - X-MOL
https://www.x-mol.com/paperRedirect/1213063437739036686
Within the pancreatic islets of T1D organ donors, CD8+ T cells comprise a majority of the infiltrating immune cells, with the remainder consisting primarily of ...
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https://www.x-mol.com/paperRedirect/1213063437739036686
Within the pancreatic islets of T1D organ donors, CD8+ T cells comprise a majority of the infiltrating immune cells, with the remainder consisting primarily of ...
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80
Two to Tango: Dialogue between Adaptive and Innate ...
https://www.hindawi.com/journals/jdr/2020/4106518/
Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells.
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https://www.hindawi.com/journals/jdr/2020/4106518/
Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells.
→ Check Latest Keyword Rankings ←
81
U of T researchers tackle type 1 diabetes with regenerative ...
https://www.utoronto.ca/news/u-t-researchers-tackle-type-1-diabetes-regenerative-medicine-technologies
Tricking the faulty immune system into beta cell tolerance ... Type 1 diabetes is, first and foremost, an autoimmune disease in which a person's ...
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https://www.utoronto.ca/news/u-t-researchers-tackle-type-1-diabetes-regenerative-medicine-technologies
Tricking the faulty immune system into beta cell tolerance ... Type 1 diabetes is, first and foremost, an autoimmune disease in which a person's ...
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82
How Lupus Affects the Immune System
https://www.hopkinslupus.org/lupus-info/lupus-affects-body/lupus-immune-system/
A group of white blood cells called lymphocytes plays a key role in the human immune response. Lymphocytes include cells called B-cells and T-cells that are ...
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https://www.hopkinslupus.org/lupus-info/lupus-affects-body/lupus-immune-system/
A group of white blood cells called lymphocytes plays a key role in the human immune response. Lymphocytes include cells called B-cells and T-cells that are ...
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83
Can diabetes be treated by blocking beta cells' destruction?
https://today.uic.edu/can-diabetes-be-treated-by-blocking-beta-cells-destruction/
The immune system produces a broad arsenal of T cells to recognize and destroy all sorts of bacteria and viruses. But some of these cells will ...
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https://today.uic.edu/can-diabetes-be-treated-by-blocking-beta-cells-destruction/
The immune system produces a broad arsenal of T cells to recognize and destroy all sorts of bacteria and viruses. But some of these cells will ...
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84
The Immune System and Primary Immunodeficiency
https://primaryimmune.org/immune-system-and-primary-immunodeficiency
When B cells encounter foreign germs (antigens), they respond by maturing into another cell type called plasma cells. B cells can also mature into memory cells, ...
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https://primaryimmune.org/immune-system-and-primary-immunodeficiency
When B cells encounter foreign germs (antigens), they respond by maturing into another cell type called plasma cells. B cells can also mature into memory cells, ...
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85
Definition of B cell - NCI Dictionary of Cancer Terms
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/b-cell
A type of white blood cell that makes antibodies. B cells are part of the immune system and develop from stem cells in the bone marrow.
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https://www.cancer.gov/publications/dictionaries/cancer-terms/def/b-cell
A type of white blood cell that makes antibodies. B cells are part of the immune system and develop from stem cells in the bone marrow.
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86
Joslin Researchers focus on beta cells to prevent destruction
https://www.joslin.org/about/news-media/pushing-early-beta-cell-proliferation-can-halt-autoimmune-attack-type-1-diabetes
We are clearly the first to show that if you push the proliferation to continuously generate new insulin producing beta-cells before the immune ...
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https://www.joslin.org/about/news-media/pushing-early-beta-cell-proliferation-can-halt-autoimmune-attack-type-1-diabetes
We are clearly the first to show that if you push the proliferation to continuously generate new insulin producing beta-cells before the immune ...
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87
Newly Discovered Immune Cell Linked to Type 1 Diabetes
https://www.hopkinsmedicine.org/news/newsroom/news-releases/newly-discovered-immune-cell-linked-to-type-1-diabetes
Credits: B and T cell images from the National Institute of Allergy ... long-doubted “X cell,” a “rogue hybrid” immune system cell that may ...
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https://www.hopkinsmedicine.org/news/newsroom/news-releases/newly-discovered-immune-cell-linked-to-type-1-diabetes
Credits: B and T cell images from the National Institute of Allergy ... long-doubted “X cell,” a “rogue hybrid” immune system cell that may ...
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88
Pancreatic beta cell senescence linked to type 1 diabetes onset
https://bionewscentral.com/pancreatic-beta-cell-senescence-linked-to-type-1-diabetes-onset/
The main approach to date has been to dampen the immune system's attack on beta cells, but these data suggest the problem may not be an ...
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https://bionewscentral.com/pancreatic-beta-cell-senescence-linked-to-type-1-diabetes-onset/
The main approach to date has been to dampen the immune system's attack on beta cells, but these data suggest the problem may not be an ...
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89
Can You Regenerate Beta Cells Naturally for Type 1 Diabetes?
https://www.masteringdiabetes.org/beta-cell-regeneration-diet/
However, this response has a side effect: when your immune system flags certain cells as foreign invaders -- like beta cells for example -- then ...
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https://www.masteringdiabetes.org/beta-cell-regeneration-diet/
However, this response has a side effect: when your immune system flags certain cells as foreign invaders -- like beta cells for example -- then ...
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90
Novel Type of Immune Cell Discovered in Type 1 Diabetes ...
https://www.the-scientist.com/news-opinion/novel-type-of-immune-cell-discovered-in-type-1-diabetes-patients-65950
The researchers suggest that these hybrids could play an important role in the disease by encouraging the immune system to attack the body's own ...
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https://www.the-scientist.com/news-opinion/novel-type-of-immune-cell-discovered-in-type-1-diabetes-patients-65950
The researchers suggest that these hybrids could play an important role in the disease by encouraging the immune system to attack the body's own ...
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91
A focus on beta cell mass could help prevent type 2 diabetes
https://researchoutreach.org/articles/focus-beta-cell-mass-could-help-prevent-type-2-diabetes/
Type 1 diabetes (T1DM) is caused by an autoimmune condition where the body's immune system attacks the beta cells, and so without beta cells ...
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https://researchoutreach.org/articles/focus-beta-cell-mass-could-help-prevent-type-2-diabetes/
Type 1 diabetes (T1DM) is caused by an autoimmune condition where the body's immune system attacks the beta cells, and so without beta cells ...
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92
Differential cell autonomous responses determine the ... - eLife
https://elifesciences.org/articles/06990
We next compared the expression of known components of the cell-autonomous immune response in α and β cells under basal conditions (Figures 6, 7) ...
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https://elifesciences.org/articles/06990
We next compared the expression of known components of the cell-autonomous immune response in α and β cells under basal conditions (Figures 6, 7) ...
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93
PDX1, Neurogenin-3, and MAFA: critical transcription ...
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-017-0694-z
Type 1 diabetes mellitus (T1D) is an autoimmune-mediated disease in which pancreatic beta cells are destroyed by the immune system, thus causing ...
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https://stemcellres.biomedcentral.com/articles/10.1186/s13287-017-0694-z
Type 1 diabetes mellitus (T1D) is an autoimmune-mediated disease in which pancreatic beta cells are destroyed by the immune system, thus causing ...
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94
Modifying the body's immune system to help treat Type 1 ...
https://showme.missouri.edu/2022/modifying-the-bodys-immune-system-to-help-treat-type-1-diabetes/
“Type 1 diabetes develops when the immune system misidentifies the insulin-producing cells in the pancreas as infections and destroys them.
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https://showme.missouri.edu/2022/modifying-the-bodys-immune-system-to-help-treat-type-1-diabetes/
“Type 1 diabetes develops when the immune system misidentifies the insulin-producing cells in the pancreas as infections and destroys them.
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95
A new approach to restore insulin production in diabetes
https://sbpdiscovery.org/news/beaker-blog/a-new-approach-to-restore-insulin-production-diabetes
In Type 1 diabetes—an autoimmune disease—beta cells are destroyed by the immune system. In Type 2 diabetes, beta cells gradually lose their ...
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https://sbpdiscovery.org/news/beaker-blog/a-new-approach-to-restore-insulin-production-diabetes
In Type 1 diabetes—an autoimmune disease—beta cells are destroyed by the immune system. In Type 2 diabetes, beta cells gradually lose their ...
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96
Stem-Cell Breakthrough in Treatment of Diabetes
https://www.harvardmagazine.com/2014/10/melton-creates-beta-cells
Beta cells are the sugar-sensing, insulin-secreting cells of the pancreas that are missing in Type 1 diabetics, casualties of the body's own ...
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https://www.harvardmagazine.com/2014/10/melton-creates-beta-cells
Beta cells are the sugar-sensing, insulin-secreting cells of the pancreas that are missing in Type 1 diabetics, casualties of the body's own ...
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