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Google Keyword Rankings for : hdac aging
1
Inactivating histone deacetylase HDA promotes longevity by ...
https://www.nature.com/articles/s41467-021-22257-2
Silencing the HDA homologs in C. elegans and Drosophila increases their lifespan and delays aging-associated physical declines in adult flies.
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https://www.nature.com/articles/s41467-021-22257-2
Silencing the HDA homologs in C. elegans and Drosophila increases their lifespan and delays aging-associated physical declines in adult flies.
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2
HDAC inhibitors: A new promising drug class in anti ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/28843433/
Inhibition of HDACs may benefit aging at all three steps of proteostasis. For instance, the first step to facilitate biogenesis of ribosomes is transcription of ...
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https://pubmed.ncbi.nlm.nih.gov/28843433/
Inhibition of HDACs may benefit aging at all three steps of proteostasis. For instance, the first step to facilitate biogenesis of ribosomes is transcription of ...
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3
HDAC Inhibitors Linked to Cellular Senescence - Lifespan.io
https://www.lifespan.io/news/hdac-inhibitors-linked-to-cellular-senescence/
A study published in Aging has shown that inhibiting histone deacetylases (HDACs), an approach used for treating cancer and other diseases, ...
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https://www.lifespan.io/news/hdac-inhibitors-linked-to-cellular-senescence/
A study published in Aging has shown that inhibiting histone deacetylases (HDACs), an approach used for treating cancer and other diseases, ...
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4
Class I HDAC Inhibitor Improves Synaptic Proteins and ...
https://www.frontiersin.org/articles/10.3389/fnagi.2020.619866/full
In this study, we examined the relationship between HDAC activity and synapse-related ... Cellular and Molecular Mechanisms of Brain-aging
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https://www.frontiersin.org/articles/10.3389/fnagi.2020.619866/full
In this study, we examined the relationship between HDAC activity and synapse-related ... Cellular and Molecular Mechanisms of Brain-aging
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5
A Review of HDAC Inhibitors as a Category of Drugs that ...
https://www.fightaging.org/archives/2019/08/a-review-of-hdac-inhibitors-as-a-category-of-drugs-that-modestly-slow-aging/
HDAC inhibitors are a comparatively poorly understood category of drugs that act to modestly slow aging in short-lived laboratory species.
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https://www.fightaging.org/archives/2019/08/a-review-of-hdac-inhibitors-as-a-category-of-drugs-that-modestly-slow-aging/
HDAC inhibitors are a comparatively poorly understood category of drugs that act to modestly slow aging in short-lived laboratory species.
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6
Histone deacetylase 4 reverses cellular senescence via ...
https://www.aging-us.com/article/204118/text
Histone deacetylases (HDACs) remove acetyl groups from lysine chains on histones and other proteins and play a crucial role in epigenetic regulation and aging.
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https://www.aging-us.com/article/204118/text
Histone deacetylases (HDACs) remove acetyl groups from lysine chains on histones and other proteins and play a crucial role in epigenetic regulation and aging.
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7
Emerging Role of HDACs in Regeneration and Ageing ... - MDPI
https://www.mdpi.com/1422-0067/23/6/2996/htm
One of these epigenetic regulations is histone acetylation by histone acetyl transferases (HATs) or histone deacetylation by histone deacetylases (HDACs). In ...
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https://www.mdpi.com/1422-0067/23/6/2996/htm
One of these epigenetic regulations is histone acetylation by histone acetyl transferases (HATs) or histone deacetylation by histone deacetylases (HDACs). In ...
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8
Influence of HDAC inhibition on the hallmarks of aging.
https://www.researchgate.net/figure/Influence-of-HDAC-inhibition-on-the-hallmarks-of-aging_fig1_334847205
... For example, histone deacetylase (HDAC) inhibitors have been shown to enhance healthy aging [10]. Though the exact process through which they extend ...
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https://www.researchgate.net/figure/Influence-of-HDAC-inhibition-on-the-hallmarks-of-aging_fig1_334847205
... For example, histone deacetylase (HDAC) inhibitors have been shown to enhance healthy aging [10]. Though the exact process through which they extend ...
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9
Histone Deacetylases (HDACs) and Associated Proteins
https://www.rndsystems.com/research-area/histone-deacetylases--hdacs--and-associated-proteins
Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer.
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https://www.rndsystems.com/research-area/histone-deacetylases--hdacs--and-associated-proteins
Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer.
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10
Study finds that aging neurons accumulate DNA damage
https://news.mit.edu/2020/aging-neurons-dna-damage-0518
DNA repair and aging. There are several members of the HDAC family of enzymes, and their primary function is to modify histones — proteins ...
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https://news.mit.edu/2020/aging-neurons-dna-damage-0518
DNA repair and aging. There are several members of the HDAC family of enzymes, and their primary function is to modify histones — proteins ...
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11
HDAC inhibitors: a new promise for anti-aging - Atlas of Science
https://atlasofscience.org/hdac-inhibitors-a-new-promise-for-anti-aging/
HDAC inhibitors: a new promise for anti-aging. Epigenetic modifications provide a mechanism of heritable but reversible changes in gene ...
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https://atlasofscience.org/hdac-inhibitors-a-new-promise-for-anti-aging/
HDAC inhibitors: a new promise for anti-aging. Epigenetic modifications provide a mechanism of heritable but reversible changes in gene ...
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12
Histone deacetylase expression and acetylation in the aging ...
https://iovs.arvojournals.org/article.aspx?articleid=2336526
Oxidative stress has similar effect on HDAC expression in primary human RPE isolates. Elevated histone acetylation could be due to reduced HDAC expression, ...
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https://iovs.arvojournals.org/article.aspx?articleid=2336526
Oxidative stress has similar effect on HDAC expression in primary human RPE isolates. Elevated histone acetylation could be due to reduced HDAC expression, ...
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13
Trichostatin A Extends the Lifespan of Drosophila ...
https://academic.oup.com/abbs/article-pdf/36/9/618/28997371/36-9-618.pdf
histone acetylation; histone deacetylase inhibitor; ... Factors influencing the aging process would change the ... studied by using HDAC inhibitors.
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https://academic.oup.com/abbs/article-pdf/36/9/618/28997371/36-9-618.pdf
histone acetylation; histone deacetylase inhibitor; ... Factors influencing the aging process would change the ... studied by using HDAC inhibitors.
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14
HDAC Inhibitors - Biochemicals - Aging - Products - BioVision
https://www.biovision.com/products/aging/aging-biochemicals/aging-biochemicals-hdac-inhibitors.html
› ... › Aging › Biochemicals
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https://www.biovision.com/products/aging/aging-biochemicals/aging-biochemicals-hdac-inhibitors.html
› ... › Aging › Biochemicals
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15
The histone deacetylase inhibitor butyrate improves ...
https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12387
Summary Sarcopenia, the loss of skeletal muscle mass and function during aging, is a major contributor to disability and frailty in the ...
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https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12387
Summary Sarcopenia, the loss of skeletal muscle mass and function during aging, is a major contributor to disability and frailty in the ...
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16
Histone deacetylase inhibitors for cardiovascular conditions ...
https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00061-1/fulltext
Histone deacetylase inhibitors (HDACi) regulate gene expression via ... The interplay between epigenetic alterations and ageing can ...
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00061-1/fulltext
Histone deacetylase inhibitors (HDACi) regulate gene expression via ... The interplay between epigenetic alterations and ageing can ...
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17
82583889.pdf - CORE
https://core.ac.uk/download/pdf/82583889.pdf
Aging process. Hippocampus. Frontal cortices. HDAC activity. Wistar rats. a b s t r a c t. It has been described that histone acetylation levels are ...
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https://core.ac.uk/download/pdf/82583889.pdf
Aging process. Hippocampus. Frontal cortices. HDAC activity. Wistar rats. a b s t r a c t. It has been described that histone acetylation levels are ...
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18
Impaired autophagy triggered by HDAC9 in mesenchymal ...
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-01785-6
Bone mass loss in aging is linked with imbalanced lineage ... Recent studies have proved that histone deacetylases (HDACs) are regarded as ...
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https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-01785-6
Bone mass loss in aging is linked with imbalanced lineage ... Recent studies have proved that histone deacetylases (HDACs) are regarded as ...
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19
Histone deacetylase 1 expression is inversely correlated with ...
https://link.springer.com/article/10.1007/s00418-018-1687-4
Aging is associated with profound changes in the epigenome, ... Class I Histone deacetylases (HDACs), consisting of HDAC1, HDAC2, HDAC3, ...
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https://link.springer.com/article/10.1007/s00418-018-1687-4
Aging is associated with profound changes in the epigenome, ... Class I Histone deacetylases (HDACs), consisting of HDAC1, HDAC2, HDAC3, ...
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20
Characterization and Classifcation of HDACs in Aging ...
https://conservancy.umn.edu/handle/11299/241249
Several studies have demonstrated that loss of HDAC expression enhances osteoclast activity. There are 18 currently identified HDACs which are divided in 3 ...
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https://conservancy.umn.edu/handle/11299/241249
Several studies have demonstrated that loss of HDAC expression enhances osteoclast activity. There are 18 currently identified HDACs which are divided in 3 ...
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21
Histone Deacetylase 3: A Potential Therapeutic Target for ...
http://www.aginganddisease.org/EN/10.14336/AD.2021.1116
Non-sirtuin histone deacetylases in the control of cardiac aging. J Mol Cell Cardiol, 83:14-20. [10]. Jung SB ...
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http://www.aginganddisease.org/EN/10.14336/AD.2021.1116
Non-sirtuin histone deacetylases in the control of cardiac aging. J Mol Cell Cardiol, 83:14-20. [10]. Jung SB ...
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22
Experience Modulates the Effects of Histone Deacetylase ...
https://www.jneurosci.org/content/35/33/11729
... Modulates the Effects of Histone Deacetylase Inhibitors on Gene and Protein Expression in the Hippocampus: Impaired Plasticity in Aging.
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https://www.jneurosci.org/content/35/33/11729
... Modulates the Effects of Histone Deacetylase Inhibitors on Gene and Protein Expression in the Hippocampus: Impaired Plasticity in Aging.
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23
Lifespan extension and elevated hsp gene expression in ...
https://journals.biologists.com/jeb/article-pdf/208/4/697/1254148/697.pdf
HDAC-dependent changes in aging and lifespan remain unclear. The aim of this study was to investigate the roles of histone hyperacetylation in expression of ...
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https://journals.biologists.com/jeb/article-pdf/208/4/697/1254148/697.pdf
HDAC-dependent changes in aging and lifespan remain unclear. The aim of this study was to investigate the roles of histone hyperacetylation in expression of ...
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24
HDAC Inhibitor Review & List - Selleck Chemicals
https://www.selleckchem.com/HDAC.html
HDAC inhibitors (inhibiting targets of signaling pathways) used for various assays, ... HDAC Signaling Pathway Map ... Front Aging Neurosci, 2020, 12:619866.
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https://www.selleckchem.com/HDAC.html
HDAC inhibitors (inhibiting targets of signaling pathways) used for various assays, ... HDAC Signaling Pathway Map ... Front Aging Neurosci, 2020, 12:619866.
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25
The Epigenetics of Aging: Understanding neurodegeneration ...
https://www.martinos.org/the-epigenetics-of-aging-understanding-neurodegeneration-at-the-gene-transcription-level/
“Animals models suggest that histone deacetylases (HDACs), enzymes that directly regulate gene transcription, may tip the balance from healthy ...
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https://www.martinos.org/the-epigenetics-of-aging-understanding-neurodegeneration-at-the-gene-transcription-level/
“Animals models suggest that histone deacetylases (HDACs), enzymes that directly regulate gene transcription, may tip the balance from healthy ...
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26
Epigenetics and aging | Science Advances
https://www.science.org/doi/10.1126/sciadv.1600584
Gene silencing requires the absence of histone acetylation within heterochromatin regions. Accordingly, treatment with histone deacetylase (HDAC) inhibitors or ...
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https://www.science.org/doi/10.1126/sciadv.1600584
Gene silencing requires the absence of histone acetylation within heterochromatin regions. Accordingly, treatment with histone deacetylase (HDAC) inhibitors or ...
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27
Development of Brain-Penetrant Histone Deacetylase ...
https://uwm.edu/drug-discovery/projects/development-of-brain-penetrant-histone-deacetylase-inhibitors-to-enhances-memory-formation/
... called histone deacetylase inhibitors (HDACi), are promising therapeutics to treat memory loss associated with aging and neurodegenerative disease.
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https://uwm.edu/drug-discovery/projects/development-of-brain-penetrant-histone-deacetylase-inhibitors-to-enhances-memory-formation/
... called histone deacetylase inhibitors (HDACi), are promising therapeutics to treat memory loss associated with aging and neurodegenerative disease.
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28
HDAC inhibitors: A new promising drug class in anti-aging ...
https://www.semanticscholar.org/paper/HDAC-inhibitors%3A-A-new-promising-drug-class-in-Pasyukova-Vaiserman/7fb8c053814f64aa139b3e9a4c308cd4d6cb98a4
Semantic Scholar extracted view of "HDAC inhibitors: A new promising drug class in anti-aging research" by E. Pasyukova et al.
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https://www.semanticscholar.org/paper/HDAC-inhibitors%3A-A-new-promising-drug-class-in-Pasyukova-Vaiserman/7fb8c053814f64aa139b3e9a4c308cd4d6cb98a4
Semantic Scholar extracted view of "HDAC inhibitors: A new promising drug class in anti-aging research" by E. Pasyukova et al.
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29
HDAC4 controls senescence and aging by safeguarding the ...
http://biorxiv.org/cgi/reprint/2020.06.04.132787v1
HDAC4 expression is silenced during cellular senescence and aging. ... ageing, we compared the protein levels of class IIa HDACs in the ...
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http://biorxiv.org/cgi/reprint/2020.06.04.132787v1
HDAC4 expression is silenced during cellular senescence and aging. ... ageing, we compared the protein levels of class IIa HDACs in the ...
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30
Emerging roles for histone deacetylases in age-related ...
https://content.iospress.com/articles/nutrition-and-healthy-aging/nha160005
BACKGROUND: Skeletal muscle atrophy during aging, a process known as ... HDAC inhibitors are already in use in the clinic, and there is ...
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https://content.iospress.com/articles/nutrition-and-healthy-aging/nha160005
BACKGROUND: Skeletal muscle atrophy during aging, a process known as ... HDAC inhibitors are already in use in the clinic, and there is ...
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31
HDAC inhibitors in the race for healthy aging drugs - ProQuest
https://search.proquest.com/openview/fbb40068a4074166a2fb0fc8aa793f88/1?pq-origsite=gscholar&cbl=866378
While targeting sirtuins for healthy aging has been extensively reviewed elsewhere, this review focuses on pharmacologically inhibiting the classical HDACs ...
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https://search.proquest.com/openview/fbb40068a4074166a2fb0fc8aa793f88/1?pq-origsite=gscholar&cbl=866378
While targeting sirtuins for healthy aging has been extensively reviewed elsewhere, this review focuses on pharmacologically inhibiting the classical HDACs ...
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32
Erasers of Histone Acetylation - CSH Perspectives
https://cshperspectives.cshlp.org/content/6/4/a018713
Erasers of Histone Acetylation: The Histone Deacetylase Enzymes ... Zinc Metabolic Defect of Aging Alveolar Progenitors in Progressive Pulmonary Fibrosis ...
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https://cshperspectives.cshlp.org/content/6/4/a018713
Erasers of Histone Acetylation: The Histone Deacetylase Enzymes ... Zinc Metabolic Defect of Aging Alveolar Progenitors in Progressive Pulmonary Fibrosis ...
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33
Analyze Histone Deacetylases (HDACs) - Active Motif
https://www.activemotif.com/catalog/451/histone-deacetylase-activity-hdac
Choose an HDAC assays that fits your workflow, from simple ELISAs to high throughput HDACi analysis & HDAC interacting protein screening.
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https://www.activemotif.com/catalog/451/histone-deacetylase-activity-hdac
Choose an HDAC assays that fits your workflow, from simple ELISAs to high throughput HDACi analysis & HDAC interacting protein screening.
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34
POWERDRESS interacts with HISTONE ... - eLife
https://elifesciences.org/articles/17214
Certain aging-related genes tightly control when and how leaves age. Like in many other organisms, plant DNA is packaged around proteins called ...
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https://elifesciences.org/articles/17214
Certain aging-related genes tightly control when and how leaves age. Like in many other organisms, plant DNA is packaged around proteins called ...
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35
Papers of the Conference on Genetics of Aging and Longevity 2012
https://books.google.com/books?id=OFk6BgAAQBAJ&pg=PA120&lpg=PA120&dq=hdac+aging&source=bl&ots=L3J_hrjacB&sig=ACfU3U0PL9wLkhMLvl51eu_BqG0Xwx1lcQ&hl=en&sa=X&ved=2ahUKEwiYgd6Ok9r7AhXVAzQIHQ-OCgAQ6AF6BQjHAhAD
Consequently, it is believed that the development of specific drugs which target HDAC activity could be a highly promising anti-aging strategy.
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https://books.google.com/books?id=OFk6BgAAQBAJ&pg=PA120&lpg=PA120&dq=hdac+aging&source=bl&ots=L3J_hrjacB&sig=ACfU3U0PL9wLkhMLvl51eu_BqG0Xwx1lcQ&hl=en&sa=X&ved=2ahUKEwiYgd6Ok9r7AhXVAzQIHQ-OCgAQ6AF6BQjHAhAD
Consequently, it is believed that the development of specific drugs which target HDAC activity could be a highly promising anti-aging strategy.
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36
HDAC1 Gene - Histone Deacetylase 1 - GeneCards
https://www.genecards.org/cgi-bin/carddisp.pl?gene=HDAC1
HDAC1 (Histone Deacetylase 1) is a Protein Coding gene. ... mortality/aging · limbs/digits/tail phenotype · cardiovascular system phenotype ...
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https://www.genecards.org/cgi-bin/carddisp.pl?gene=HDAC1
HDAC1 (Histone Deacetylase 1) is a Protein Coding gene. ... mortality/aging · limbs/digits/tail phenotype · cardiovascular system phenotype ...
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37
HDAC inhibitor–dependent transcriptome and memory ... - JCI
https://www.jci.org/articles/view/79942
Amyloid pathology impaired histone acetylation and decreased expression of plasticity genes, while aging altered H4K12 acetylation–linked ...
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https://www.jci.org/articles/view/79942
Amyloid pathology impaired histone acetylation and decreased expression of plasticity genes, while aging altered H4K12 acetylation–linked ...
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38
CoREST Complex-Selective Histone Deacetylase Inhibitors ...
https://www.reachbio.com/hubfs/CoREST%20complex-selective%20histone%20deacetylase%20inhibitors%20show%20prosynaptic%20effects%20and%20an%20improved%20safety%20profile%20to%20enable%20treatment%20of%20synapt.pdf
Many studies with HDAC inhibitors (HDACi) have shown ... normal aging in Alzheimer's disease. Nat. Neurosci. 21, 497−505.
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https://www.reachbio.com/hubfs/CoREST%20complex-selective%20histone%20deacetylase%20inhibitors%20show%20prosynaptic%20effects%20and%20an%20improved%20safety%20profile%20to%20enable%20treatment%20of%20synapt.pdf
Many studies with HDAC inhibitors (HDACi) have shown ... normal aging in Alzheimer's disease. Nat. Neurosci. 21, 497−505.
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39
Rapid reversion of aging phenotypes by nicotinamide through ...
https://www.rutchem.rutgers.edu/images/images/faculty/chen/sub-site/pubs/1998-2001/last_in_2001.pdf
Cell aging; human diploid fibroblast; nicotinamide; histone acetylation; rejuvenation. ... involvement of N-HDAC in the aging of mammalian.
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https://www.rutchem.rutgers.edu/images/images/faculty/chen/sub-site/pubs/1998-2001/last_in_2001.pdf
Cell aging; human diploid fibroblast; nicotinamide; histone acetylation; rejuvenation. ... involvement of N-HDAC in the aging of mammalian.
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40
Time-dependent modulation of FoxO activity by HDAC ...
https://www.aimspress.com/article/id/1825
The characteristic ROS increase during aging may be responsible for the decreased HDAC activity, which facilitates the senescent-like phenotype.
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https://www.aimspress.com/article/id/1825
The characteristic ROS increase during aging may be responsible for the decreased HDAC activity, which facilitates the senescent-like phenotype.
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41
The Enigmatic Role of Sir2 in Aging - Cell Press
https://www.cell.com/fulltext/S0092-8674(05)01160-8
) examine the role of Sir2, a histone deacetylase, in chronological aging in yeast by measuring the long-term survival of nondividing cells. In contrast to ...
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https://www.cell.com/fulltext/S0092-8674(05)01160-8
) examine the role of Sir2, a histone deacetylase, in chronological aging in yeast by measuring the long-term survival of nondividing cells. In contrast to ...
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42
Epigenetics of Aging - Page 413 - Google Books Result
https://books.google.com/books?id=9aE1-ODR90kC&pg=PA413&lpg=PA413&dq=hdac+aging&source=bl&ots=tXOHuv16y0&sig=ACfU3U2m-3pCPKjRYnRRGl_7xrFyj0TgPQ&hl=en&sa=X&ved=2ahUKEwiYgd6Ok9r7AhXVAzQIHQ-OCgAQ6AF6BQjIAhAD
that dietary compounds such as butyrate, diallyl disulfide (DADS), and sulforaphane (SFN) act as weak ligands for HDACs and exhibit HDAC inhibitory activity ...
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https://books.google.com/books?id=9aE1-ODR90kC&pg=PA413&lpg=PA413&dq=hdac+aging&source=bl&ots=tXOHuv16y0&sig=ACfU3U2m-3pCPKjRYnRRGl_7xrFyj0TgPQ&hl=en&sa=X&ved=2ahUKEwiYgd6Ok9r7AhXVAzQIHQ-OCgAQ6AF6BQjIAhAD
that dietary compounds such as butyrate, diallyl disulfide (DADS), and sulforaphane (SFN) act as weak ligands for HDACs and exhibit HDAC inhibitory activity ...
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43
HDAC Inhibition Reverses Preexisting Diastolic Dysfunction ...
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.046462
HDAC inhibition blocks extracellular matrix remodeling and increases left ... to prevent DD in Dahl salt-sensitive rats and aging mice; ...
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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.046462
HDAC inhibition blocks extracellular matrix remodeling and increases left ... to prevent DD in Dahl salt-sensitive rats and aging mice; ...
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44
Histone deacetylase controls adult stem cell aging by ...
https://europepmc.org/article/pmc/pmc2835723
Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3. · Author information · Abstract ...
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https://europepmc.org/article/pmc/pmc2835723
Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3. · Author information · Abstract ...
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45
Histone deacetylase signaling plays a critical role in age ...
https://unthsc-ir.tdl.org/handle/20.500.12503/27960
Aging is associated with a striking increase in the incidence of stroke and neurodegenerative diseases, both of which are major causes of ...
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https://unthsc-ir.tdl.org/handle/20.500.12503/27960
Aging is associated with a striking increase in the incidence of stroke and neurodegenerative diseases, both of which are major causes of ...
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46
Therapeutic Targeting of Histone Deacetylation to Prevent ...
https://emrespublisher.com/open-access-pdf/therapeutic-targeting-of-histone-deacetylation-to-prevent-alzheimers-disease-100020.pdf
HDAC inhibitors target several pathways associated with aging and AD neuropathology including loss of synaptic.
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https://emrespublisher.com/open-access-pdf/therapeutic-targeting-of-histone-deacetylation-to-prevent-alzheimers-disease-100020.pdf
HDAC inhibitors target several pathways associated with aging and AD neuropathology including loss of synaptic.
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47
Expression of histone deacetylase (HDAC) family members in ...
https://cdrjournal.com/article/view/4316
Cumulatively our findings highlight distinct roles for HDAC6 and HDAC7 in regulating cell death in the context of bortezomib resistance. Keywords. Histone ...
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https://cdrjournal.com/article/view/4316
Cumulatively our findings highlight distinct roles for HDAC6 and HDAC7 in regulating cell death in the context of bortezomib resistance. Keywords. Histone ...
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48
A deep dive into cellular aging | Sanford Burnham Prebys
https://sbpdiscovery.org/news/a-deep-dive-into-cellular-aging
Treating senescent cells with an FDA-approved HDAC inhibitor (HDACi) decreased cytoplasmic chromatin (white arrows)—a mix of DNA and protein ...
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https://sbpdiscovery.org/news/a-deep-dive-into-cellular-aging
Treating senescent cells with an FDA-approved HDAC inhibitor (HDACi) decreased cytoplasmic chromatin (white arrows)—a mix of DNA and protein ...
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49
Age, Alzheimer's-related brain decline linked to little-studied ...
https://jagwire.augusta.edu/age-alzheimers-related-brain-decline-linked-to-little-studied-enzyme/
HDAC, or histone deacetylase, levels overall are associated with normal brain aging as well as neurodegenerative diseases like Alzheimer's.
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https://jagwire.augusta.edu/age-alzheimers-related-brain-decline-linked-to-little-studied-enzyme/
HDAC, or histone deacetylase, levels overall are associated with normal brain aging as well as neurodegenerative diseases like Alzheimer's.
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50
Anti-aging pharmacology - SCRX Life Force
https://www.scrxlifeforce.com/img/pdfs/MESENCHYME/Article-%20Anti-aging.pdf
aging pharmacology is a rapidly developing discipline. It is a preventive field of health ... aging drug candidates (Vaiserman and Pasyukova, 2012). HDAC.
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https://www.scrxlifeforce.com/img/pdfs/MESENCHYME/Article-%20Anti-aging.pdf
aging pharmacology is a rapidly developing discipline. It is a preventive field of health ... aging drug candidates (Vaiserman and Pasyukova, 2012). HDAC.
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51
Anti-aging Drugs: From Basic Research to Clinical Practice
https://books.google.com/books?id=7msoDwAAQBAJ&pg=PA517&lpg=PA517&dq=hdac+aging&source=bl&ots=XPL3eOhaEM&sig=ACfU3U2xJfDr-u-zglcRC24y0OzROJpMdg&hl=en&sa=X&ved=2ahUKEwiYgd6Ok9r7AhXVAzQIHQ-OCgAQ6AF6BQjJAhAD
HDACs, on the contrary, catalyze the removal of acetyl groups from lysine residues of histone tails, resulting in a more condensed, transcriptionally ...
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https://books.google.com/books?id=7msoDwAAQBAJ&pg=PA517&lpg=PA517&dq=hdac+aging&source=bl&ots=XPL3eOhaEM&sig=ACfU3U2xJfDr-u-zglcRC24y0OzROJpMdg&hl=en&sa=X&ved=2ahUKEwiYgd6Ok9r7AhXVAzQIHQ-OCgAQ6AF6BQjJAhAD
HDACs, on the contrary, catalyze the removal of acetyl groups from lysine residues of histone tails, resulting in a more condensed, transcriptionally ...
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52
Uncovering Robust Delactoylase and Depyruvoylase ...
https://pubs.acs.org/doi/10.1021/acschembio.1c00863
Zinc-dependent histone deacetylases (HDACs) and sirtuins (SIRT) represent ... (12) enriched in aging mice liver tissue and liver cirrhosis.
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https://pubs.acs.org/doi/10.1021/acschembio.1c00863
Zinc-dependent histone deacetylases (HDACs) and sirtuins (SIRT) represent ... (12) enriched in aging mice liver tissue and liver cirrhosis.
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53
Epigenetic regulation of cell fate reprogramming in aging and ...
https://journals.plos.org/ploscompbiol/article/figures?id=10.1371/journal.pcbi.1006052
A stochastic model of aging metabolism-regulated cell fate. ... We examine the stability properties of the QSSA as when eHDM and eHDAC are varied.
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https://journals.plos.org/ploscompbiol/article/figures?id=10.1371/journal.pcbi.1006052
A stochastic model of aging metabolism-regulated cell fate. ... We examine the stability properties of the QSSA as when eHDM and eHDAC are varied.
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54
Aging neurons accumulate DNA damage - ScienceDaily
https://www.sciencedaily.com/releases/2020/05/200518090030.htm
DNA repair and aging. There are several members of the HDAC family of enzymes, and their primary function is to modify histones -- proteins ...
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https://www.sciencedaily.com/releases/2020/05/200518090030.htm
DNA repair and aging. There are several members of the HDAC family of enzymes, and their primary function is to modify histones -- proteins ...
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55
Surprise: HDAC Goes Down, Not Up, in Alzheimer's Disease
https://www.alzforum.org/news/conference-coverage/surprise-hdac-goes-down-not-alzheimers-disease
... accumulate while HDAC levels (right) wane in posterior cingulate cortices (arrow), compared with healthy elderly control brains.
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https://www.alzforum.org/news/conference-coverage/surprise-hdac-goes-down-not-alzheimers-disease
... accumulate while HDAC levels (right) wane in posterior cingulate cortices (arrow), compared with healthy elderly control brains.
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56
Relapsed/Refractory Hodgkin Lymphoma | News Releases
https://www.aacr.org/about-the-aacr/newsroom/news-releases/combined-inhibition-of-hdac-and-mtor-may-improve-outcomes-in-patients-with-relapsed-refractory-hodgkin-lymphoma/
he histone deacetylase (HDAC) inhibitor vorinostat (Zolinza) in combination with the mTOR inhibitor sirolimus (Rapamune) or everolimus ...
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https://www.aacr.org/about-the-aacr/newsroom/news-releases/combined-inhibition-of-hdac-and-mtor-may-improve-outcomes-in-patients-with-relapsed-refractory-hodgkin-lymphoma/
he histone deacetylase (HDAC) inhibitor vorinostat (Zolinza) in combination with the mTOR inhibitor sirolimus (Rapamune) or everolimus ...
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57
The quality control theory of aging
https://www.tandfonline.com/doi/pdf/10.3402/pba.v4.24835
chemical chaperone that enhances ER function and is also an HDAC inhibitor, ... A critical aspect of the QC theory, then, is that aging is.
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https://www.tandfonline.com/doi/pdf/10.3402/pba.v4.24835
chemical chaperone that enhances ER function and is also an HDAC inhibitor, ... A critical aspect of the QC theory, then, is that aging is.
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58
Verdin Lab - Buck Institute for Research on Aging
https://www.buckinstitute.org/lab/verdin-lab/
Dr. Verdin studies how metabolism, diet, and small molecules regulate the activity of HDACs and sirtuins, and thereby the aging process and its associated ...
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https://www.buckinstitute.org/lab/verdin-lab/
Dr. Verdin studies how metabolism, diet, and small molecules regulate the activity of HDACs and sirtuins, and thereby the aging process and its associated ...
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59
Decreased Histone Deacetylase Activity in Chronic ...
https://www.nejm.org/doi/full/10.1056/nejmoa041892
by K Ito · 2005 · Cited by 1173 —
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https://www.nejm.org/doi/full/10.1056/nejmoa041892
by K Ito · 2005 · Cited by 1173 —
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60
Modulation of Life-span by Histone Deacetylase Genes ...
https://www.molbiolcell.org/doi/10.1091/mbc.10.10.3125
... time that is observed during yeast aging. Deletion of HDA1, another histone deacetylase gene, did not result in life-span extension, ...
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https://www.molbiolcell.org/doi/10.1091/mbc.10.10.3125
... time that is observed during yeast aging. Deletion of HDA1, another histone deacetylase gene, did not result in life-span extension, ...
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61
Hsiao-Ying Wey, PhD - American Federation for Aging Research
https://www.afar.org/grantee-profiles/hsiao-ying-wey
Histone deacetylases (HDACs) are a family of epigenetic enzymes that dynamically regulate gene transcription by chemically modifying the DNA base and ...
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https://www.afar.org/grantee-profiles/hsiao-ying-wey
Histone deacetylases (HDACs) are a family of epigenetic enzymes that dynamically regulate gene transcription by chemically modifying the DNA base and ...
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62
An Attractive Therapeutic Strategy Against Breast Cancer
https://ar.iiarjournals.org/content/37/1/35
The aforementioned data are just an example of using HDACs as an anticancer target. HDAC inhibitors, enhance the acetylation of cellular proteins by blocking ...
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https://ar.iiarjournals.org/content/37/1/35
The aforementioned data are just an example of using HDACs as an anticancer target. HDAC inhibitors, enhance the acetylation of cellular proteins by blocking ...
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63
The Ability of Carnitine to Act as a Type 1 Histone Deacetylase ...
https://esmed.org/MRA/mra/article/download/2055/193545524/
those in muscle, decline during aging; carnitine supplementation restores higher, ... functions as an inhibitor of type 1 histone deacetylases (HDACs).
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https://esmed.org/MRA/mra/article/download/2055/193545524/
those in muscle, decline during aging; carnitine supplementation restores higher, ... functions as an inhibitor of type 1 histone deacetylases (HDACs).
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64
Dr. Eric Verdin on Ketogenic Diet Longevity, Beta ... - YouTube
https://www.youtube.com/watch?v=9qOQGBVedAQ
FoundMyFitness
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https://www.youtube.com/watch?v=9qOQGBVedAQ
FoundMyFitness
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65
HDAC9, Aging and Alzheimer's Disease - Xin-Yun Lu
https://grantome.com/grant/NIH/R56-AG064895-01
We found that aging increases expression of histone deacetylase 9 (HDAC9), an endogenous repressor of adipogenic differentiation, in human and mouse adipose ...
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https://grantome.com/grant/NIH/R56-AG064895-01
We found that aging increases expression of histone deacetylase 9 (HDAC9), an endogenous repressor of adipogenic differentiation, in human and mouse adipose ...
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66
Dietary natural products as epigenetic modifiers in aging
https://pubs.rsc.org/en/content/getauthorversionpdf/c9np00057g
Over time, however, as observed in aging, the inflammatory ... inflammation and the HDAC inhibitor, valproic acid, was the first of its kind ...
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https://pubs.rsc.org/en/content/getauthorversionpdf/c9np00057g
Over time, however, as observed in aging, the inflammatory ... inflammation and the HDAC inhibitor, valproic acid, was the first of its kind ...
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67
Butyrate Histone Deacetylase Inhibitors - Mary Ann Liebert, Inc.
https://www.liebertpub.com/doi/10.1089/biores.2012.0223
1) is a potent and specific inhibitor of mammalian histone deacetylase (HDAC) activity in vivo, and that this inhibition strongly induced tumor ...
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https://www.liebertpub.com/doi/10.1089/biores.2012.0223
1) is a potent and specific inhibitor of mammalian histone deacetylase (HDAC) activity in vivo, and that this inhibition strongly induced tumor ...
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68
Histone H4 lysine 16 hypoacetylation is associated ... - PNAS
https://www.pnas.org/doi/pdf/10.1073/pnas.1102789108
histone deacetylase inhibition promoted repair protein recruit- ment to DNA damage sites and substantially ameliorated aging-.
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https://www.pnas.org/doi/pdf/10.1073/pnas.1102789108
histone deacetylase inhibition promoted repair protein recruit- ment to DNA damage sites and substantially ameliorated aging-.
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69
Histone deacetylase enzymes and ... - OAE Publishing Inc.
https://www.oaepublish.com/neurosciences/article/view/2897
Histone deacetylases (HDACs) play important roles in epigenetic changes and HDAC inhibitors as immunomodulatory agents have been useful in the preclinical arena ...
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https://www.oaepublish.com/neurosciences/article/view/2897
Histone deacetylases (HDACs) play important roles in epigenetic changes and HDAC inhibitors as immunomodulatory agents have been useful in the preclinical arena ...
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70
HDAC Inhibitors as Epigenetic Regulators of the Immune ...
https://www.hindawi.com/journals/bmri/2016/8797206/
Histone deacetylase (HDAC) inhibitors are powerful epigenetic regulators that ... functions such as oxidative stress, DNA repair, metabolism, and aging [.
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https://www.hindawi.com/journals/bmri/2016/8797206/
Histone deacetylase (HDAC) inhibitors are powerful epigenetic regulators that ... functions such as oxidative stress, DNA repair, metabolism, and aging [.
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71
POWERDRESS interacts with HISTONE DEACETYLASE 9 to ...
https://smith.chem.wisc.edu/content/powerdress-interacts-histone-deacetylase-9-promote-aging-arabidopsis
POWERDRESS interacts with HISTONE DEACETYLASE 9 to promote aging in Arabidopsis. Posted on: 6 March 2017; By: admin ...
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https://smith.chem.wisc.edu/content/powerdress-interacts-histone-deacetylase-9-promote-aging-arabidopsis
POWERDRESS interacts with HISTONE DEACETYLASE 9 to promote aging in Arabidopsis. Posted on: 6 March 2017; By: admin ...
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72
Effect of the Histone Deacetylase Inhibitor FRM-0334 on ...
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2784478
Ljubenkov, MD, Memory and Aging Center, Department of Neurology, University of California at San Francisco, Weill Institute for Neurosciences, ...
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https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2784478
Ljubenkov, MD, Memory and Aging Center, Department of Neurology, University of California at San Francisco, Weill Institute for Neurosciences, ...
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73
GenAge entry for HDAC2 (Homo sapiens)
https://genomics.senescence.info/genes/entry.php?hgnc=HDAC2
HGNC symbol: HDAC2; Aliases: RPD3; YAF1; Common name: histone deacetylase 2 ... Whether HDAC2 is involved in human ageing, however, is not known.
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https://genomics.senescence.info/genes/entry.php?hgnc=HDAC2
HGNC symbol: HDAC2; Aliases: RPD3; YAF1; Common name: histone deacetylase 2 ... Whether HDAC2 is involved in human ageing, however, is not known.
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74
The onset and development of age-related osteoarthritis | JIR
https://www.dovepress.com/the-level-of-histone-deacetylase-4-is-associated-with-aging-cartilage--peer-reviewed-fulltext-article-JIR
The Level of Histone Deacetylase 4 is Associated with Aging Cartilage Degeneration and Chondrocyte Hypertrophy.
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https://www.dovepress.com/the-level-of-histone-deacetylase-4-is-associated-with-aging-cartilage--peer-reviewed-fulltext-article-JIR
The Level of Histone Deacetylase 4 is Associated with Aging Cartilage Degeneration and Chondrocyte Hypertrophy.
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75
Targeting Histone Deacetylases for Cancer Therapy
https://www.ijbs.com/v10p0757.htm
Biological functions of HDACs. Cellular functions regulated by HDACs, including apoptosis, DNA damage repair, cell cycle control, autophagy, metabolism, ageing ...
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https://www.ijbs.com/v10p0757.htm
Biological functions of HDACs. Cellular functions regulated by HDACs, including apoptosis, DNA damage repair, cell cycle control, autophagy, metabolism, ageing ...
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76
Role of histone deacetylase 2 in epigenetics and cellular ...
https://journals.physiology.org/doi/full/10.1152/ajplung.00175.2012
the inflammaging refers to chronic low-grade inflammation with aging, which occurs in chronic inflammatory diseases, such as chronic obstructive pulmonary ...
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https://journals.physiology.org/doi/full/10.1152/ajplung.00175.2012
the inflammaging refers to chronic low-grade inflammation with aging, which occurs in chronic inflammatory diseases, such as chronic obstructive pulmonary ...
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77
Dietary Histone Deacetylase Inhibitors (HDAC) - Full Text View
https://clinicaltrials.gov/show/NCT01543074
› show › NCT01543074
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https://clinicaltrials.gov/show/NCT01543074
› show › NCT01543074
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78
040 Dr. Eric Verdin on Ketogenic Diet Longevity, Beta ...
https://foundmyfitness.libsyn.com/dr-eric-verdin-on-ketogenic-diet-longevity-beta-hydroxybutyrate-hdac-inhibitors
10:42 - The role of insulin pathways in aging; 16:25 - HDAC inhibition by ketones; 27:52 - Protein activates mTOR & IGF-1; 30:28 - PPAR-alpha ...
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https://foundmyfitness.libsyn.com/dr-eric-verdin-on-ketogenic-diet-longevity-beta-hydroxybutyrate-hdac-inhibitors
10:42 - The role of insulin pathways in aging; 16:25 - HDAC inhibition by ketones; 27:52 - Protein activates mTOR & IGF-1; 30:28 - PPAR-alpha ...
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79
190703-HDAC | Martinos Center
https://webdev.nmr.mgh.harvard.edu/the-epigenetics-of-aging-understanding-neurodegeneration-at-the-gene-transcription-level/190703-hdac/
July 8, 2019 Gary Boas. Home / The Epigenetics of Aging: Understanding neurodegeneration at the gene transcription level / 190703-HDAC ...
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https://webdev.nmr.mgh.harvard.edu/the-epigenetics-of-aging-understanding-neurodegeneration-at-the-gene-transcription-level/190703-hdac/
July 8, 2019 Gary Boas. Home / The Epigenetics of Aging: Understanding neurodegeneration at the gene transcription level / 190703-HDAC ...
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80
文章详细信息 - 生命的化学
http://www.life.ac.cn/WKD/WebPublication/paperDigest.aspx?paperID=4b33bb28-cc93-4efa-9dcf-8e2e96219b19
Protein and mitochondria quality control mechanisms and cardiac aging. ... Recent developments of HDAC inhibitors:emerging indications and novel molecules.
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http://www.life.ac.cn/WKD/WebPublication/paperDigest.aspx?paperID=4b33bb28-cc93-4efa-9dcf-8e2e96219b19
Protein and mitochondria quality control mechanisms and cardiac aging. ... Recent developments of HDAC inhibitors:emerging indications and novel molecules.
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81
ISG15 Is a Novel Regulator of Lipid Metabolism during ...
https://journals.asm.org/doi/abs/10.1128/spectrum.03893-22?af=R
... autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62. ... in the context of cellular and organismal health and aging.
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https://journals.asm.org/doi/abs/10.1128/spectrum.03893-22?af=R
... autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62. ... in the context of cellular and organismal health and aging.
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82
Scientists can reverse aging in mice. The goal is to do ... - CNN
https://www.cnn.com/2022/06/02/health/reverse-aging-life-itself-scn-wellness/index.html
Using proteins that can turn an adult cell into a stem cell, Sinclair and his team have reset aging cells in mice to earlier versions of ...
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https://www.cnn.com/2022/06/02/health/reverse-aging-life-itself-scn-wellness/index.html
Using proteins that can turn an adult cell into a stem cell, Sinclair and his team have reset aging cells in mice to earlier versions of ...
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83
Identification of HDAC10 Inhibitors that Modulate Autophagy ...
https://chemrxiv.org/engage/chemrxiv/article-details/61e8014c4a603d28203565b6
Abstract. Histone deacetylases (HDACs) are a family of 18 epigenetic modifiers that fall into 4 classes. Histone deacetylase inhibitors (HDACi) ...
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https://chemrxiv.org/engage/chemrxiv/article-details/61e8014c4a603d28203565b6
Abstract. Histone deacetylases (HDACs) are a family of 18 epigenetic modifiers that fall into 4 classes. Histone deacetylase inhibitors (HDACi) ...
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84
Chromatin structure influences the sensitivity of DNA to γ ...
https://developers.lokasi.live/jawaban-https-www.academia.edu/50039181/Chromatin_structure_influences_the_sensitivity_of_DNA_to_%CE%B3_radiation?from_sitemaps=true&version=2
Topoisomerase II and histone deacetylase inhibitors delay the G2/M ... targets of a persistent DNA damage response in ageing and stress-induced senescence.
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https://developers.lokasi.live/jawaban-https-www.academia.edu/50039181/Chromatin_structure_influences_the_sensitivity_of_DNA_to_%CE%B3_radiation?from_sitemaps=true&version=2
Topoisomerase II and histone deacetylase inhibitors delay the G2/M ... targets of a persistent DNA damage response in ageing and stress-induced senescence.
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85
Scientists discover key driver of human aging - Salk Institute
https://www.salk.edu/news-release/scientists-discover-key-driver-of-human-aging/
LA JOLLA–A study tying the aging process to the deterioration of tightly packaged bundles of cellular DNA could lead to methods of preventing ...
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https://www.salk.edu/news-release/scientists-discover-key-driver-of-human-aging/
LA JOLLA–A study tying the aging process to the deterioration of tightly packaged bundles of cellular DNA could lead to methods of preventing ...
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86
Histone deacetylase - Wikipedia
https://en.wikipedia.org/wiki/Histone_deacetylase
Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, ...
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https://en.wikipedia.org/wiki/Histone_deacetylase
Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, ...
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87
Sulforaphane nedir, faydaları ve yan etkileri nelerdir ...
https://yerelhaberler.net.tr/haber/sulforaphane-nedir-faydalari-ve-yan-etkileri-nelerdir-yerelhaberler/
Sülforafan antioksidan, antimikrobiyal, antikanser, antiinflamatuar, anti-aging, ... SFN, şimdiye kadarki en güçlü HDAC (histon deasetilaz) ...
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https://yerelhaberler.net.tr/haber/sulforaphane-nedir-faydalari-ve-yan-etkileri-nelerdir-yerelhaberler/
Sülforafan antioksidan, antimikrobiyal, antikanser, antiinflamatuar, anti-aging, ... SFN, şimdiye kadarki en güçlü HDAC (histon deasetilaz) ...
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88
Scientists Can Reverse DNA Aging in Mice - TIME
https://time.com/4711023/how-to-keep-your-dna-from-aging/
They focused on an intriguing compound with anti-aging properties called NAD+, short for nicotinamide adenine dinucleotide. It's been known that ...
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https://time.com/4711023/how-to-keep-your-dna-from-aging/
They focused on an intriguing compound with anti-aging properties called NAD+, short for nicotinamide adenine dinucleotide. It's been known that ...
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89
Emerging potential for HDACIs in ALS
https://www.als.net/news/dot12-emerging-potential-for-hdacs-in-als/
Now, a growing number of scientists are developing so-called “next-generation” histone deacetylase (HDAC) inhibitors in hopes to create safe and ...
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https://www.als.net/news/dot12-emerging-potential-for-hdacs-in-als/
Now, a growing number of scientists are developing so-called “next-generation” histone deacetylase (HDAC) inhibitors in hopes to create safe and ...
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