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1 Tyrosine kinase inhibitors and modifications of thyroid function ...
https://eje.bioscientifica.com/view/journals/eje/160/3/331.xml
TKI affect thyroid function through different physiopathological mechanisms that can impair the thyroid tissue or the thyroid hormone metabolism.
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2 Hypothyroidism during cancer therapy with tyrosine kinase ...
https://www.thyroid.org/patient-thyroid-information/ct-for-patients/january-2019/vol-12-issue-1-p-9-10/
Hypothyroidism is often seen in patients being treated with TKI drugs for non-thyroidal cancers. Interestingly, the development of hypothyroidism during ...
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3 Hypothyroidism related to tyrosine kinase inhibitors - Nature
https://www.nature.com/articles/nrclinonc.2009.4
Targeted therapies such as tyrosine kinase inhibitors (TKI) have been shown to induce hypothyroidism and thyroid dysfunction. The management of thyroid ...
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4 Cancer patients with TKI-induced hypothyroidism ... - MDedge
https://www.mdedge.com/chestphysician/article/152157/pituitary-thyroid-adrenal-disorders/cancer-patients-tki-induced
VICTORIA, B.C. – When it comes to the adverse effects of tyrosine kinase inhibitors (TKIs), hypothyroidism appears to have a bright side, ...
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5 Frequency and Severity of Hypothyroidism During TKI Therapy...
https://journals.lww.com/jpho-online/Fulltext/2022/10000/Frequency_and_Severity_of_Hypothyroidism_During.18.aspx
AML indicates acute myeloid leukemia; TFT, thyroid function test; VEGFR-TKI, Tyrosine kinase inhibitors that target vascular endothelial growth factor receptor.
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6 Tyrosine kinase inhibitors and immune checkpoint inhibitors ...
https://www.sciencedirect.com/science/article/am/pii/S1040842819301076
symptomatic treatment of hyperthyroidism and/or correcting hypothyroidism. ... Thus, TKI-induced thyroid toxicity involves mainly compounds targeting ...
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7 Risk Factors for New Hypothyroidism During Tyrosine Kinase ...
https://www.liebertpub.com/doi/10.1089/thy.2017.0579
Background: Thyroid dysfunction during tyrosine kinase inhibitor (TKI) cancer treatment is common, but predisposing risk factors have not ...
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8 Continued Discontinuation of TKI Treatment in Medullary ...
https://www.frontiersin.org/articles/10.3389/fendo.2021.718418/full
BackgroundThe tyrosine kinase inhibitors (TKI) vandetanib and cabozantinib are approved as targeted therapies in advanced medullary thyroid ...
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9 Hypothyroidism related to tyrosine kinase inhibitors
https://www.endocrine-abstracts.org/ea/0022/ea0022p835
Thyroid function tests (TFT) were assessed prior to treatment with TKI in 6 patients (all euthyroid) and during or after treatment with TKI in 13 patients ...
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10 Thyroid autoimmunity and hypothyroidism are associated with ...
https://link.springer.com/article/10.1007/s40618-021-01613-5
Discussion · After the introduction of TKI therapy, hypothyroidism induced by imatinib has been frequently reported in patients with solid tumors ...
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11 Auto-immune thyroid dysfunction induced by ... - BMC Cancer
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2705-3
We report here a case of hyperthyroidism with positive anti-TSH receptor antibodies after treatment with two different successive TKI, sorafenib ...
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12 P49-5 Tyrosine kinase inhibitor-induced thyroid dysfunction in ...
https://www.annalsofoncology.org/article/S0923-7534(21)01971-2/fulltext
Tyrosine kinase inhibitors (TKIs) are molecular targeted therapies used in the treatment of various malignancies. Thyroid dysfunction is an increasingly ...
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13 Medline ® Abstract for Reference 161 of 'Toxicity ... - UpToDate
https://www.uptodate.com/contents/toxicity-of-molecularly-targeted-antiangiogenic-agents-non-cardiovascular-effects/abstract/161
RESULTS Scholars have studied the clinical relationship between hypothyroidism and TKI treatment and its molecular biology mechanism.
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14 BCR‐ABL1 tyrosine kinase inhibitor‐associated thyroid ...
https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.25997
Among the BCR-ABL TKIs, hypothyroidism, hyperthyroidism, and thyroiditis ... The exact mechanism underlying BCR-ABL1 TKI-induced thyroid ...
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15 Overt Hypothyroidism Induced by Prolonged Therapy With ...
https://academic.oup.com/jes/article-abstract/5/Supplement_1/A945/6241050
Abstract. Background: Imatinib, a tyrosine kinase inhibitor (TKI), is commonly used to treat chronic myelogenous leukemia (CML) and ...
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16 Adaptive Tyrosine Kinase Inhibitor (TKI) Therapy In Patients ...
https://clinicaltrials.gov/ct2/show/NCT03630120
Participants will have been diagnosed with advanced progressive thyroid cancer and are about to start treatment with a tyrosine kinase inhibitor (TKI).
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17 Frequency and Severity of Hypothyroidism During TKI ...
https://www.ingentaconnect.com/content/wk/jpho/2022/00000044/00000007/art00018
These results suggest moderate risk of developing thyroid dysfunction during VEGFR-TKI therapy in pediatric and young adult patients. Baseline thyroid hormone ...
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18 Hypothyroidism Side Effect in Patients Treated with Sunitinib ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147048
TKI-induced hypothyroidism is a highly complicated issue, because of not only the unrealized toxicological mechanisms, but also different ...
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19 Association between new onset hypothyroidism and clinical ...
https://aacrjournals.org/cancerres/article/74/19_Supplement/2827/594776/Abstract-2827-Association-between-new-onset
TKI-induced thyroid dysfunction has been identified as an important but potentially manageable toxicity of targeted therapy. Relationship ...
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20 Thyroid Function Abnormalities in Patients Receiving VEGF ...
https://www.hematologyandoncology.net/archives/april-2011/thyroid-function-abnormalities-in-patients-receiving-vegf-targeted-therapy/
... initiating any TKI therapy for cancer treatment should undergo TSH evaluation prior to each cycle of therapy.12 Clearly, thyroid axis surveillance is ...
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21 Expert opinion on thyroid complications of new anti-cancer ...
https://www.sfendocrino.org/_images/mediatheque/articles/pdf/recommandations/2018_Immunotherapies%20/7_drui2018.pdf
Thyroid pathology is the most frequent form of endocrinopathy during tyrosine kinase inhibitor (TKI) treatment. Dysthyroidism occurs in 10% to.
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22 TKI-induced hypothyroidism common, but exact causes ...
https://www.healio.com/hematology-oncology/head-neck-cancer/news/print/endocrine-today/%7B942916d3-6b6e-4a81-9d29-3cc62c92c794%7D/tki-induced-hypothyroidism-common-but-exact-causes-remain-unclear
TKI-induced hypothyroidism is commonly seen with some TKI due to either increased T4 metabolism or changes on the vascular supply to the thyroid ...
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23 Management of hypothyroidism secondary to tyrosine kinase ...
https://www.elsevier.es/index.php?p=revista&pRevista=pdf-simple&pii=S2173509311700174&r=412
made in standard clinical practice and on retrospective studies. three different clinical scenarios of tKi-induced hypothyroidism assessed in our outpatient ...
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24 A Case Report of Severe Hypocalcemia and Hypothyroidism ...
https://www.ijthyroid.org/journal/view.html?uid=310&&vmd=Full
Division of Endocrinology, Center for Thyroid Cancer, ... TKI-related hypothyroidism is related to the metabolic rate of thyroid hormones.
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25 Hypothyroidism Related to Cancer Treatment Linked to ...
https://www.medscape.com/viewarticle/887367
Thyroid dysfunction is known to occur with TKI treatment, and while there have been some reports of potential survival benefits with ...
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26 Axitinib-Induced Hypothyroidism as a Predictor of Long-Term ...
https://www.karger.com/Article/Fulltext/499089
Keywords: Metastatic renal cell carcinomaAxitinibHypothyroidism ... Even with the same TKI, the frequency of hypothyroidism may show racial ...
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27 Increased Thyroid-Hormone Requirements Consistent With ...
https://www.aaceclinicalcasereports.com/article/S2376-0605(20)31026-9/abstract
We present the first case to link these findings to the TKI ibrutinib. Methods. Serial thyroid-stimulating hormone (TSH), free-thyroxine (FT4), ...
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28 Hyperlipidemia and Hypothyroidism and TKI Response in ...
https://www.practiceupdate.com/content/hyperlipidemia-and-hypothyroidism-and-tki-response-in-metastatic-renal-cell-carcinoma/37228/26/0/1
Hyperlipidemia and Hypothyroidism and TKI Response in Metastatic Renal Cell Carcinoma. Asia-Pacific Journal of Clinical Oncology.
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29 (PDF) Hypothyroidism related to tyrosine kinase inhibitors
https://www.researchgate.net/publication/24245506_Hypothyroidism_related_to_tyrosine_kinase_inhibitors_An_emerging_toxic_effect_of_targeted_therapy
The safety and efficacy, and optimal dosing and timing of starting replacement therapy in patients affected by TKI-related hypothyroidism need ...
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30 Acquired Hypothyroidism in Patients with Metastatic Renal ...
https://www.dovepress.com/acquired-hypothyroidism-in-patients-with-metastatic-renal-cell-carcino-peer-reviewed-fulltext-article-DDDT
Most studies hold that hypothyroidism occurring during TKI therapy may serve as potential biomarkers of response and efficacy of treatment, but ...
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31 Medscape - Overt hypothyroidism TKI treatment for cancer...
https://www.facebook.com/medscape/posts/10156444904289189
Overt hypothyroidism TKI treatment for cancer is associated with a significant survival benefit: http://ms.spr.ly/6181rF4RX.
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32 Current evidence on thyroid related adverse events in patients ...
https://www.tandfonline.com/doi/abs/10.1080/03602532.2019.1687512
Tyrosine kinase inhibitors (TKI) are gaining more ground in oncology, they are widely used in the treatment of multiple types of cancers; still important ...
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33 Tyrosine kinase inhibitor-induced hypothyroidism - ProQuest
https://search.proquest.com/openview/cd5ddd036f283651c108ad0c5fb0368a/1?pq-origsite=gscholar&cbl=1486337
In addition, TKI-induced thyroid dysfunction is now recognized as a common toxicity that is associated with some TKI inhibitors. Detection of TKI-induced ...
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34 Tyrosine kinase inhibitors–induced hypothyroidism as a ...
https://www.researchsquare.com/article/rs-36842/v2.pdf
with tyrosine kinase inhibitors-induced (TKI-induced) hypothyroidism. we aimed to evaluate the predictive value of TKI-induced.
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35 is tyrosine kinase inhibitors the cause of thyroid stimulating ...
https://apm.amegroups.com/article/view/101926/html
Tumor progression with thyrotoxicosis on differentiated thyroid ... between TKI administration and appearance of thyroid stimulating hormone ...
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36 Cancer patients with TKI-induced hypothyroidism ... - PM360
https://www.pm360online.com/cancer-patients-with-tki-induced-hypothyroidism-had-better-survival-rates/
During TKI therapy, 26.7% of patients developed overt hypothyroidism, and another 13.2% developed subclinical hypothyroidism. “For a given drug, ...
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37 Management of VEGFR-Targeted TKI for Thyroid Cancer - MDPI
https://www.mdpi.com/2072-6694/13/21/5536/htm
Thyroid cancer patients generally undergo such loco-regional procedures before TKI therapy, thus increasing the risk of fistula. Delayed wound healing due to ...
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38 About targeted cancer drugs for thyroid cancer
https://www.cancerresearchuk.org/about-cancer/thyroid-cancer/treatment/targeted-cancer-drugs-thyroid
The targeted cancer drugs that are used in thyroid cancer are called tyrosine kinase inhibitors (TKIs). TKI's block a cancer cell chemical messenger called ...
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39 Thyroid Damage from Tyrosine Kinase Inhibitors
https://www.gistsupport.org/ask-the-professional/thyroid-damage-from-tyrosine-kinase-inhibitors/
After how short or long a time in treatment may this show up, and should monitoring go on as long as patients remain on TKI therapy? Thyroid function ...
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40 8 Medications That Can Cause Hypothyroidism - GoodRx
https://www.goodrx.com/drugs/side-effects/medications-that-can-cause-hypothyroidism
The longer you take a TKI, the higher your risk of developing hypothyroidism. But about half of people who develop hypothyroidism while ...
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41 Definition of tyrosine kinase inhibitor - National Cancer Institute
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/tyrosine-kinase-inhibitor
Prostate Cancer · Skin Cancer · Thyroid Cancer · Uterine Cancer · All Cancer Types · A to Z List of Cancers · Cancers by Body Location · Childhood Cancers ...
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42 Tyrosine Kinase Inhibitors (TKIs) - Thyroid Cancer Canada
https://www.thyroidcancercanada.org/en/treatments/tyrosine-kinase-inhibitors
A small percentage of patients with metastatic (cancerous cells that have spread) differentiated thyroid cancer do not respond to radioactive iodine (RAI) ...
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43 Thyroid Diseases - Page 481 - Google Books Result
https://books.google.com/books?id=t_jRBQAAQBAJ&pg=PA481&lpg=PA481&dq=hypothyroidism+tki&source=bl&ots=eZOQ2Uvw_5&sig=ACfU3U27FVNJe-10EELglZ3I1I0NRC__DQ&hl=en&sa=X&ved=2ahUKEwiJ0uL-3tr7AhW4kIkEHXV6BzkQ6AF6BQiYAhAD
Sorabefin) or (2) by causing primary hypothyroidism in previously euthyroid ... Sunitinib, a multitargeted TKI approved to treat metastatic renal cell ...
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44 Expert opinion on thyroid complications of ... - Read by QxMD
https://read.qxmd.com/read/30126626/expert-opinion-on-thyroid-complications-of-new-anti-cancer-therapies-tyrosine-kinase-inhibitors
Thyroid pathology is the most frequent form of endocrinopathy during tyrosine kinase inhibitor (TKI) treatment. Dysthyroidism occurs in 10% to 80% of cases, ...
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45 How to manage CML patients with comorbidities | Blood
https://ashpublications.org/blood/article/136/22/2507/474218/How-to-manage-CML-patients-with-comorbidities
Suggestions for TKI selection for frontline therapy based on selected ... Assess together with thyroid assessment; hypothyroidism should be ...
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46 [PDF] Tyrosine Kinase Inhibitors: A Foe for the Thyroid?
https://www.semanticscholar.org/paper/Tyrosine-Kinase-Inhibitors%3A-A-Foe-for-the-Thyroid-Kaltsas/f61f05f393899b474566fd43b1c50e4e8c33a0f7
The observation that TKI-induced thyroid dysfunction may actually be protective as it was shown to improve overall survival, ...
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47 Hypothyroidism with Sunitinib Therapy and its Correlation with ...
https://www.ejmi.org/pdf/Hypothyroidism%20with%20Sunitinib%20Therapy%20and%20its%20Correlation%20with%20Survival%20Outcomes%20in%20Advanced%20Renal%20Cell%20Carcinoma%20Patients-19385.pdf
Keywords: Hypothyroidism, progression free survival, renal cell carcinoma, sunitinib ... The molecular mechanisms of TKI-induced hypothyroidism.
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48 Thyroid Dysfunction as an Unintended Side Effect of ...
https://art.torvergata.it/retrieve/handle/2108/101154/206128/Torino%20et%20al.%20Thyroid2013.pdf
The worsening of appropriately treated hypothyroidism in thyroidectomized patients under imatinib, a TKI mainly tar- geting c-KIT, was the first thyroid hormone ...
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49 The Role of the Kinase Inhibitors in Thyroid Cancers - MDPI
https://mdpi-res.com/d_attachment/pharmaceutics/pharmaceutics-14-01040/article_deploy/pharmaceutics-14-01040-v2.pdf?version=1652331454
Keywords: cancer; thyroid; TKI therapy; chemoresistance; trials. 1. Introduction. 1.1. Differentiated Thyroid Cancer. Differentiated thyroid ...
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50 Problem Solving in Acute Oncology: Second Edition
https://books.google.com/books?id=DEO4DwAAQBAJ&pg=PA85&lpg=PA85&dq=hypothyroidism+tki&source=bl&ots=rK1MZcvOoU&sig=ACfU3U3fqHDhBTOmUsYPHbcPAg3yXm5GlA&hl=en&sa=X&ved=2ahUKEwiJ0uL-3tr7AhW4kIkEHXV6BzkQ6AF6BQiUAhAD
Most thyroid dysfunction associated with TKI use is asymptomatic biochemical subclinical hypothyroidism (raised TSH, with thyroid hormones within the ...
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51 Tyrosine kinase inhibitors and modifications of ... - Europe PMC
https://europepmc.org/article/med/19103722
Tyrosine kinase inhibitors (TKI) belong to new molecular multi-targeted therapies that are approved for the treatment of haematological and solid tumours.
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52 Tyrosine Kinase Inhibitors and the Thyroid as Both an ...
https://www.endocrinepractice.org/article/S1530-891X(20)41101-2/abstract
TKI. tyrosine kinase inhibitor. TKs. tyrosine kinases. TSH. thyroid-stimulating hormone (thyrotropin). VEGF. vascular endothelial growth factor.
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53 Anticancer Drug-induced Thyroid Dysfunction
https://www.touchendocrinology.com/wp-content/uploads/sites/5/2020/02/touchENDO_EU_16.1_p32-39.pdf
The TKI most frequently associated with development of new onset hypothyroidism is sunitinib.21–6 It is approved for the treatment of RCC.
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54 GILTERITINIB MEDIATED HYPOTHYROIDISM PRESENTING ...
https://www.jacc.org/doi/10.1016/S0735-1097%2820%2933539-7
Tyrosine Kinase Inhibitors (TKI) have become an important modality for targeted cancer therapy. These novel agents have improved survivorship ...
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55 Sunitinib-induced Thyrotoxicosis – A not so Rare Entity
https://ar.iiarjournals.org/content/anticanres/35/1/481.full.pdf
Table I. Comparison of incidence of thyroid dysfunction in our and similar studies. Tumor type. TKI. Patients (N). Thyrotoxicosis. Hypothyroidism.
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56 Hypothyroidism in patients with colorectal carcinoma treated ...
https://www.spandidos-publications.com/10.3892/or.2013.2644
Thyroid function in colorectal cancer patients receiving ... of the pathogenesis of TKI-induced hypothyroidism have been considered.
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57 Is hypothyroidism a clinically relevant toxicity of tyrosine ... - Gale
https://go.gale.com/ps/i.do?id=GALE%7CA199990681&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=10507256&p=HRCA&sw=w
sub.4]-Rx) has been reported in hypothyroid patients during treatment with imatinib, another tyrosine kinase inhibitor (TKI) (5), and possibly also during ...
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58 Therapy with tyrosine kinase inhibitor lenvatinib in radioactive ...
https://www.futuremedicine.com/doi/10.2217/ije-2019-0007
Lenvatinib is a tyrosine kinase inhibitor (TKI) approved for the management of radioactive iodine (RAI) refractory differentiated thyroid ...
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59 Immunotherapy and TKI Combinations Are Emerging as ...
https://www.targetedonc.com/view/immunotherapy-and-tki-combinations-are-emerging-as-standard-of-care-in-advanced-rcc
› view › immunotherapy-...
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60 Acquired Hypothyroidism as a Predictive Marker of Outcome ...
https://www.clinical-genitourinary-cancer.com/article/S1558-7673(14)00232-8/pdf
Hypothyroidism in patients with metastatic renal cell carcinoma (mRCC) ... The development of hypothyroidism during TKI therapy is not clearly shown to be ...
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61 Alteration of thyroid functions in patients with renal cell ...
https://dergipark.org.tr/tr/download/article-file/265225
In this study we investigated thyroid stimulant hormone change with TKI therapy and relation between the oncologic outcomes in Turkish patient population.
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62 Endocrinological Side Effects of Ibrutinib
https://wmjonline.org/wp-content/uploads/2020/119/4/293.pdf
as adrenal insufficiency, thyroid dysfunction, hyperparathyroidism, and gonadal failure in some tyrosine kinase inhibitors (TKI).
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63 Thyroid Function Abnormalities in Patients Receiving ...
https://www.intechopen.com/chapters/37926
Alternatively, an interference of sunitinib with thyroid hormone action at the pituitary level has been suggested [122]. TKI-induced hypothyroidism ( de novo ...
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64 Tyrosine kinase inhibitors–induced hypothyroidism as a ...
https://www.researcher-app.com/paper/5412344
we aimed to evaluate the predictive value of TKI-induced hypothyroidism for progression-free survival (PFS) in patients with mRCC. Methods: PubMed, Web of ...
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65 Nektar and Bristol Myers Squibb Announce Update on Clinical ...
https://news.bms.com/news/details/2022/Nektar-and-Bristol-Myers-Squibb-Announce-Update-on-Clinical-Development-Program-for-Bempegaldesleukin-BEMPEG-in-Combination-with-Opdivo-nivolumab/default.aspx
... in the doublet therapy arm compared to the TKI arm, the companies ... In patients receiving OPDIVO monotherapy, hypothyroidism occurred ...
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66 Auto-immune thyroid dysfunction induced by tyrosine kinase ...
https://d-nb.info/1114353086/34
Keywords: Auto-immune thyroid dysfunction, Tyrosine kinase inhibitors, Chordoma. Abbreviations: fT3, Free triiodothyronine; fT4, Free thyroxine; TKI, ...
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67 Treatment for Advanced Thyroid Cancer
https://www.butterfly.org.uk/about-thyroid-cancer/treatment-advanced-thyroid-cancer/
Use of TKI drugs in the UK for advanced Thyroid Cancer. There are new anticancer drugs called 'tyrosine kinase inhibitors' (TKIs) which are becoming ...
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68 External Beam Radiation Therapy for Thyroid Cancer
https://www.cancer.org/cancer/thyroid-cancer/treating/external-beam-radiation.html
External beam radiation therapy is a treatment that uses high-energy rays or particles to destroy thyroid cancer cells. Learn more here.
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69 Tyrosine Kinase Inhibitors - TMedWeb
https://tmedweb.tulane.edu/pharmwiki/doku.php/tyrosine_kinase_inhibitors
intracellular kinases: c-CRAF, BRAF & mutant BRAF. Indications: Hepatocellular Carcinoma. Renal Cell Carcinoma. Differentiated Thyroid Carcinoma ...
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70 Targeted treatment for advanced thyroid cancer FAQs
https://www.btf-thyroid.org/targeted-treatment-for-advanced-thyroid-cancer-faqs
› targeted-treatment-for-ad...
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71 Read Online The History Of Endocrine Surgery Read Pdf Free
https://partylikeadeejay.deejay.it/reader/particle?i=F9N3R9&FileName=The+History+Of+Endocrine+Surgery
and Parathyroid Glands Atlas of Thyroid Surgery Surgical Endocrinology Atlas of Thyroid Disorders and ... New chapters cover medical oncology and TKI.
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72 ThyCa: Thyroid Cancer Survivors' Association, Inc.
https://www.thyca.org/
ThyCa: Thyroid Cancer Survivors' Association, Inc. is a nonprofit 501(c)(3) organization (tax ID #52-2169434) of thyroid cancer survivors, family members, ...
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73 Drug-Induced Hypothyroidism - Cancer Therapy Advisor
https://www.cancertherapyadvisor.com/home/decision-support-in-medicine/labmed/drug-induced-hypothyroidism/
Drug-induced hypothyroidism is an under active thyroid gland caused by certain medications. The medications that can cause hypothyroidism may be drugs normally ...
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74 Hypothyroidism - Physiopedia
https://www.physio-pedia.com/Hypothyroidism
Hypothyroidism is caused by an insufficient amount of the thyroid hormone in the body resulting in an overall slowing of metabolism.
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75 Subclinical Hypothyroidism - What You Need to Know | RHR
https://chriskresser.com/subclinical-hypothyroidism-what-you-need-to-know/
In this podcast Dr. Amy Nett and I will discuss the thyroid physiology behind subclinical hypothyroidism and its clinical consequences.
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76 Why doctors now warn against routinely treating mild thyroid ...
https://www.cbc.ca/news/health/hypothyroidism-subclinical-1.5138719
They compared the effects of thyroid hormone treatment with no treatment or placebo among adults with subclinical hypothyroidism. Synthroid was ...
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77 Ask the Experts - Thyroid Cancer - YouTube
https://www.youtube.com/watch?v=hVkrh7yRVfk
Moffitt Cancer Center
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