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1 Biotin - Wikipedia
https://en.wikipedia.org/wiki/Biotin
Biotin (or vitamin B7) is one of the B vitamins. It is involved in a wide range of metabolic ... For biotin labeling purposes 100% of the daily value was 300 μg/day, ...
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2 Biotin (YMDB00282) - Yeast Metabolome Database
http://www.ymdb.ca/compounds/YMDB00282
Biotin is an extremely weak basic (essentially neutral) compound (based on its pKa) ... Property, Value, Reference ... pKa (Strongest Acidic), 4.4, ChemAxon.
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3 D-Biotin | 58-85-5 - ChemicalBook
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB3271542.htm
D-Biotin Properties ; powder · 4.74±0.10(Predicted) · White crystalline powder or fine long needles · 4.5 (0.1g/l, H2O) · [α]20/D +91±2°, c = 1% in 0.1 M NaOH.
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4 Biotin: Uses, Interactions, Mechanism of Action - DrugBank
https://go.drugbank.com/drugs/DB00121
Biotin is a B-complex vitamin found in many multivitamin products. ... Harvest Of Values All B Complex Tab, Biotin (30 mcg) + Choline bitartrate (200 mg) + ...
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5 Showing Compound Biotin (FDB014510) - FooDB
https://foodb.ca/compounds/FDB014510
Biotin is used in cell growth, the production of fatty acids, ... Property, Value, Source ... pKa (Strongest Acidic), -3.4, ChemAxon.
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6 Showing metabocard for Biotin (HMDB0000030)
https://hmdb.ca/metabolites/HMDB0000030
Biotin is also known as coenzyme R and vitamin H or B7. It occurs mainly bound to proteins or ... Adduct Type, Data Source, CCS Value (Å2), Reference ...
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7 47868 - D-Biotin analytical standard - Sigma-Aldrich
https://www.sigmaaldrich.com/IN/en/product/supelco/47868
No rating value. Be the first to write a review . This action will open a modal dialog. Filter by Rating. Rating, 1 ...
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8 Solved please show me how to solve this equation. biotin pka
https://www.chegg.com/homework-help/questions-and-answers/please-show-solve-equation-biotin-pka-value-45-biotin-found-someones-urine-ph-63-would-cha-q91479355
please show me how to solve this equation. biotin pka value 4.5. if biotin was found in someones urine at pH 6.3, which would there be more of, the charge or ...
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9 2RTG: STREPTAVIDIN-BIOTIN COMPLEX, PH 2.40, SPACE ...
https://www.rcsb.org/structure/2rtg
Method: X-RAY DIFFRACTION; Resolution: 1.39 Å; R-Value Free: 0.223; R-Value Work: ... Binding of biotin to streptavidin stabilizes intersubunit salt bridges ...
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10 Crystal Structure of Biotin Carboxylase in Complex with ...
https://www.jbc.org/article/S0021-9258(20)76962-0/fulltext
These enzymes share a conserved biotin carboxylase (BC) component, which catalyzes the ... 1E), which should reduce its apparent pKa value.
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11 Biotin-Labelled Clavulanic Acid to Identify Proteins Target for ...
https://www.frontiersin.org/articles/10.3389/fphar.2020.594755/full
From these residues, we assume lysine as the residue with the highest reactivity toward this compound, due to its lower pka and previous ...
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12 Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New ...
https://pubs.acs.org/doi/pdf/10.1021/acschembio.9b00463
base or a means for decreasing the pKa of biotin. Second, the ... solution was treated with a small amount of activated charcoal, filtered,.
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13 ANALYSES OF MULTIVITAMINS IN NUTRACEUTICALS BY ...
https://tigerprints.clemson.edu/cgi/viewcontent.cgi?article=2736&context=all_theses
previously mentioned, some B group vitamins (e.g. biotin, folic acid, ... 0.01% aqueous solution of biotin has a pH of 4.5 with the pKa value of 4.51.
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14 PKA Activity as Measured Using a 96-Well Biotin-Capture Plate
https://www.researchgate.net/figure/PKA-Activity-as-Measured-Using-a-96-Well-Biotin-Capture-Plate_tbl1_11067168
Furthermore, there seems to be no bias towards finding compounds within a particular range of logP values, even though compounds are solubilized from a dry ...
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15 Organelle pH studies using targeted avidin and fluorescein ...
https://www.sciencedirect.com/science/article/pii/S1074552100000880
A pH-sensitive, membrane-permeable fluorescein–biotin was targeted ... not only ratiometric but also have a broad range of pKa values (4–7).
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16 D-Biotin D-sulfoxide (ECMDB20288) (M2MDB001127) - ECMDB
https://ecmdb.ca/compounds/M2MDB001127
logP, -2, ChemAxon ; logS, -1.6, ALOGPS ; pKa (Strongest Acidic), 3.58, ChemAxon ; pKa (Strongest Basic), 6.07, ChemAxon.
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17 conjugated anticancer thiosemicarbazones and their iron(III ...
https://core.ac.uk/download/pdf/162167752.pdf
synthesized the first biotin-functionalized thiosemicarbazone derivatives in ... Comparison of pKa values and lipophilicity of Triapine and BioTriapine.
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18 Biotin-tagged fluorescent sensor to visualize 'mobile' Zn
http://www.rsc.org/suppdata/c8/cc/c8cc05425h/c8cc05425h1.pdf
determine the apparent pKa values of 7. Fig. S5 Fluorescence emission spectra of sensor (a) 7 (50 µM) and (b) 7 + Zn2+ (50 µM) at different pH.
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19 12 Biotin - Springer Link
https://link.springer.com/content/pdf/10.1007%2F978-1-4899-3414-7_12.pdf
Biotin functions as the prosthetic group in carboxylase enzymes, which ... pH of a 0.01% aqueous solution of biotin is 4.5; the pKa value is 4.5l.
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20 Amino acid pKa and pKi values - Isca Biochemicals
https://www.iscabiochemicals.com/page/32/amino-acid-pka-and-pki-values
Amino acid pKa and pKi values ; Aspartic acid, D · 1.88, 9.60, 3.65 ; Glutamic acid, E · 2.19, 9.67, 4.25 ; Lysine, K · 2.18, 8.95, 10.53 ...
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21 Biotin Enhances Testosterone Production in Mice and Their ...
https://www.mdpi.com/2072-6643/14/22/4761/htm
However, in the presence of biotin (4 µM or 40 µM), H-89 abolished the enhancement of testosterone levels by biotin. As PKA is a protein kinase activated by ...
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22 Biotin (carboxylated biotin derivatives) - INTERCHIM
https://www.interchim.fr/ft/1/10685A.pdf
(Ka>10-11 Mol –1) specific binding characteristics of biotin whereas at acidic pH values the salt form of the analog interacts poorly with avidin.
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23 Crystal Structure of Biotin Carboxylase in Complex with ...
http://tonglab.biology.columbia.edu/Research/bc_substrate.pdf
The amount of carboxybiotin produced by BC was deter- ... the active site of BC is expected to reduce this pKa value, which should facilitate the extraction ...
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24 Nonenzymatic biotinylation of a biotin carboxyl carrier protein
https://onlinelibrary.wiley.com/doi/pdf/10.1110/ps.062187306
Recently certain mutants of the Escherichia coli biotin protein ligase have been shown to ... terized by masses close to the predicted values (Table 1).
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25 Effect of biotin and pantothenic acid on performance and ...
https://www.journalofdairyscience.org/article/S0022-0302(15)00437-3/pdf
These observations suggest that pantothenic acid did not affect the absorption of biotin. Weak acids would be best absorbed at pH values below their pKa ( ...
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26 Metabolism of Biotin and Analogues of Biotin by Microorganisms
http://jb.asm.org/content/92/4/913.full.pdf
Further Studies on the Conversion of D-Biotin to Biotin Vitamers by. Lactobacillus plantarum ... L-sulfoxide), the assay values obtained with this or-.
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27 Computational Characterization of Carboxyphosphate
https://dsc.duq.edu/cgi/viewcontent.cgi?article=1074&context=etd
by biotin carboxylase. However, it is questionable whether this mechanism is plausible for this enzyme. Bicarbonate has a pKa value of 10.3103 requiring a ...
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28 calculated pka values: Topics by Science.gov
https://www.science.gov/topicpages/c/calculated+pka+values
The revised intrinsic pKa value helps explains why arginine side chains in proteins are ... Immunocytochemistry revealed TG2-mediated biotin-X-cadaverine ...
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29 Phosphorylation of CFTR by PKA promotes binding of the ...
https://www.embopress.org/doi/10.1038/sj.emboj.7600747
SplitΔR was not co-precipitated if biotin was omitted from the reaction mix ... in the presence of MgATP+PKA (Figure 4B), similar to the value obtained when ...
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30 EPAC2 Polyclonal Antibody, Biotin - Thermo Fisher Scientific
https://www.thermofisher.com/order/catalog/product/EPAC2-BIOTIN
Fabgennix Anti-EPAC2 Polyclonal, Catalog # EPAC2-BIOTIN. ... Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.
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31 Direct molecular level measurements of the electrostatic ...
https://www.pnas.org/doi/10.1073/pnas.95.22.12961
Independent measurements showed that the charge density of the biotin-lipid membrane is pH-independent, within experimental error, at the pH values investigated ...
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32 Anti-PRKACG Rabbit Polyclonal Antibody (Biotin) - VWR
https://ca.vwr.com/store/product/en/17129566/anti-prkacg-rabbit-polyclonal-antibody-biotin
PKA (or cAPK) is a cyclic AMP dependent protein kinase. When activated by the second messenger cAMP, PKA mediates diverse cellular mechanisms, ...
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33 Novel Insights into the Biotin Carboxylase Domain Reactions ...
https://epublications.marquette.edu/cgi/viewcontent.cgi?article=1106&context=bio_fac
Biotin Carboxylase Domain Reactions of Pyruvate Carboxylase from Rhizobium etli" ... While the E218Q mutant retained a small amount of.
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34 Microarray analysis of pancreatic gene expression during ...
https://cdnsciencepub.com/doi/10.1139/cjpp-2014-0517
In humans, biotin deficiency is relatively rare but can cause dermatitis, ... DAVID employs a modified Fisher exact P-value (the EASE score) to assess ...
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35 Compound Report Card - CHEMBL857 - EMBL-EBI
https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL857/
Biotin BIOTIN D-BIOTIN MD-1003 NSC-63865 RITATIN ... The value returned can also be 'empty' if the model was not able to predict the compound or 'both' if ...
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36 Site-directed mutagenesis studies of E. coli biotin carboxylase
https://digitalcommons.lsu.edu/cgi/viewcontent.cgi?article=2560&context=gradschool_dissertations
the pKa of Lys 238 was found to be 9.4 or higher, making it an unlikely ... amount of carboxybiotin produced by biotin carboxylase was determined using a.
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37 Biotin receptor-targeting nanogels loaded with methotrexate ...
https://doi.org/10.1016/j.ijpharm.2022.122049
It has pH-dependent solubility (about 0.01 mg/ml in distilled water at 20 °C) and pKa values of 3.8, 4.8, and 5.6 (Vaidyanathan et al., ...
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38 The Development Of Chemical Methods To Discover Kinase ...
https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=2697&context=oa_dissertations
3.2.5 K-BILDS identified previously known PKA substrates . ... dividing the value with ATP by the ATP-biotin value.
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39 Effects of different levels of dietary biotin on the performance ...
https://www.tandfonline.com/doi/pdf/10.4081/ijas.2007.5
Some significant differences (P<0.05) were observed between groups, but the values of all the parameters appeared randomly distributed around those of the ...
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40 Detecting Protein#Ligand Binding on Supported Bilayers by ...
https://cpb-us-e1.wpmucdn.com/sites.psu.edu/dist/e/3050/files/2013/04/84-hyunsook.pdf
This method was used to detect antibiotin/biotin binding interactions as well as ... locate the pKA value of ortho-Texas Red DHPE. The pH could be.
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41 ATP-polyamine-biotin | CS-5373 | Universal Biologicals
https://www.universalbiologicals.com/atp-polyamine-biotin-cs-5373
ATP-polyamine-biotin promotes biotin labeling of kinase substrates in live cells. In Vitro: ATP-polyamine-biotin (APB) is incubated with PKA kinase and full- ...
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42 Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase ...
https://jpet.aspetjournals.org/content/jpet/363/2/240.full.pdf
This may help to minimize inhibition of off- target cysteine kinases that exhibit higher cysteine pKa values than that for Cys481 in BTK. Indeed, acalabrutinib.
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43 simulation of a silicon nanowire fet biosensor for detecting
http://d-scholarship.pitt.edu/8622/1/Yucai_Wang_ETD2010_2.pdf
The pKa value of biotin is 4.66 [62], so at. pH=7, each biotin molecule carry net charge of α=1/(1+104.66-7)≈-1q. This result coincides with.
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44 Biotin - MarkerDB
https://markerdb.ca/chemicals/MDB00000015
Abnormal Levels - Diagnostic ; General Condition(s):, Others ; Biofluid: Cerebrospinal_Fluid ; Disease concentration: 0.023 (0.022-0.023) uM ; P-value: 0.0.
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45 Fluorescence modulation sensing of positively and negatively ...
https://avs.scitation.org/doi/pdf/10.1186/1559-4106-8-1
form, were utilized as sensor platforms for biotin-avidin and biotin-streptavidin ... pKa of the ortho-rhodamine B dye to more basic values.
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46 Vitamins: Water and Fat Soluble
https://themedicalbiochemistrypage.org/vitamins-water-and-fat-soluble/
However, it is thought that biotin may lead to increased expression of SLC19A3 gene. Activation of Thiamine. Thiamine is rapidly converted to ...
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47 Critical Review—Electrochemical Properties of 13 Vitamins
https://iopscience.iop.org/article/10.1149/2.1471714jes/pdf
and six protonations characterized by pKa values.7 ... (b) The water soluble B vitamins all contain nitrogen. Biotin also contains sulfur.
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48 Molecular mechanism of the intestinal biotin transport process
https://journals.physiology.org/doi/pdf/10.1152/ajpcell.1999.277.4.C605
rat small intestine that appears to be involved in biotin transport. The open reading frame of ... diaminobiotin with inhibition constant (Ki) values (de-.
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49 Fluorescence modulation sensing of ... - Biointerphases
https://biointerphases.springeropen.com/articles/10.1186/1559-4106-8-1
The membranes contained 5 mol% biotin-PE (1 ... sensitivity and shift the apparent pKa of the ortho-rhodamine B dye to more basic values.
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50 Molecular Recognition of Biotin Derivatives
https://digital.library.adelaide.edu.au/dspace/bitstream/2440/19678/2/02whole.pdf
3.2.3 Relationship between intra-molecular hydrogen bonding and pKc value 27. 3.2. 4 Chiral aminolysis of biotin esters with arylmethylamines and amino acid ...
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51 Label-Free Detection of Low Protein Concentration in - ERA
https://era.library.ualberta.ca/items/79cff866-491c-4ed4-bdea-ebe76be7b4e3/view/e35b02dd-680a-4c05-9cce-45dfe8bebac6/BAB_49_133.pdf
The pKa value of acrylic acid is ~4.25, i.e., increasing the pH of a ... carbodiimide hydrochloride), Biotin-modified magnetic particles (average diameter ...
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52 HHS Public Access - OSTI.gov
https://www.osti.gov/servlets/purl/1186930
Product Binding in Haemophilus influenzae Biotin Carboxylase ... with respect to carbamoyl phosphate with a Ki value of 2.2 ± 0.2 mM. Thus, the kinetic data.
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53 Selective N-terminal acylation of peptides and proteins with a ...
https://www.nature.com/articles/s41467-018-05695-3.pdf?origin=ppub
to its pKa value that is lower (pKa 7.6-8.0) than for Lys side-chain ... jugation of functional molecules such as biotin. We demonstrate.
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54 Biotin-Decorated PAMAM G4.5 Dendrimer Nanoparticles to ...
https://mdpi-res.com/d_attachment/pharmaceutics/pharmaceutics-12-00443/article_deploy/pharmaceutics-12-00443.pdf
PG4.5-DETA-biotin/GEM nanoparticles selectively targeted cancer cells in vitro. ... The low pKa value of the PAMAM dendrimer reduces.
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55 Preparation of Developing Biotinylated PH-Responsive ...
https://www.fortunejournals.com/articles/preparation-of-developing-biotinylated-phresponsive-glycopolymers-as-delivery-nanocarriers-for-controlling-release-of-bortezomib.html
Assemblies were formed from pH-sensitive glycopolymers Biotin-P(GAMA25-co-PDEA30) and Biotin-P(GAMA25-b-DEA30) in aqueous solution at different pH values. The ...
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56 Quantitative H2S-mediated protein sulfhydration ... - eLife
https://elifesciences.org/articles/10067v1.pdf
pKa values and serve as a major target for oxidative modifications, which can ... binding of the biotin-labeled proteins on an avidin column, (3) elution of ...
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57 Label-free Detection of Low Protein Concentration in Solution ...
https://digitalcommons.chapman.edu/cgi/viewcontent.cgi?article=1231&context=sees_articles
The pKa value of acrylic acid is ~4.25, i.e., increasing the pH of a ... carbodiimide hydrochloride), Biotin-modified magnetic particles ...
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58 Proximity Labeling-assisted Identification of Endogenous ...
https://www.biorxiv.org/content/10.1101/2020.06.09.143370v2.full.pdf
Kinase substrate, BioID (proximity-dependent biotin identification), ... phosphorylation by CK2 or PKA, and thus might alter downstream ...
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59 Intermolecular Forces and Energies Between Ligands and ...
https://www.jstor.org/stable/2884765
biotin, and base, respectively. The initial reaction, corresponding to the deprotona- tion of the guanidine group of iminobiotin. (pKa, where Ka is the acid ...
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60 Supramolecular Assembly of Three-Dimensional Protein ...
https://uwspace.uwaterloo.ca/bitstream/handle/10012/16233/Merza_Fatima.pdf?sequence=3
reactions on in order to display free biotin molecules on the protein's surface ... compounds have a very similar pKa value for the phosphorous atoms of the ...
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61 modified biotin-binding proteins for immobilization
https://patents.justia.com/patent/20200354783
In one class of embodiments, the biotin-binding protein has a calculated net charge of −10 or less at pH 7.4, e.g., −15 or less, −20 or less, ...
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62 Biotin-Linked Polyclonal Antibody to Collagen Type I (COL1)
http://www.cloud-clone.com/products/LAA571Hu71.html
INCREMENT SERVICES ; Advanced Healthcare Materials, Prognostic value of fibrosis-related markers in dilated cardiomyopathy: A link between osteopontin and ...
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63 Men's Sexual Health: Medicine, Toys & More - Hims
https://www.forhims.com/sexual-health
› sexual-health
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64 Biotin CAS 58-85-5 - United States Biological
https://www.usbio.net/biochemicals/B1750/Biotin-DBiotin-Vitamin-H-Coenzyme-R-Bioepiderm
B1750 Biotin (D-Biotin, Vitamin H, Coenzyme R, Bioepiderm) CAS: 58-85-5 ; Ash. ≤0.1% ; Solubility. Biotin is not very soluble (0.02g/100ml of hot dH2O and in 95% ...
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65 Til4 ionic compound name - Savemi Costruzioni
https://savemicostruzioni.it/til4-ionic-compound-name.html
Jan 02, 2022 · Til4 ionic compound name Y: Property Name Property Value Reference; ... biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin ...
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66 biotin | C10H16N2O3S - ChemSpider
http://www.chemspider.com/Chemical-Structure.149962.html
biotin. Molecular FormulaC10H16N2O3S; Average ...
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67 Biotin - Family Practice Notebook
https://fpnotebook.com/pharm/Vitamins/Btn.htm
This page includes the following topics and synonyms: Biotin, Vitamin B7, Vitamin H, Coenzyme R.
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68 D-Biotin vitamin B7 | C10H16N2O3S - Supreme Pharmatech
https://supremepharmatech.com/en/process/ingredient-database/d-biotin-vitamin-b7.html
D-Biotin vitamin B7 | C10H16N2O3S | Structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, ...
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69 Biotin Vitamin B7 Molecule
https://www.worldofmolecules.com/supplements/biotin.htm
In order to include a fair amount of biotin in the diet, you should consume foods like egg yolks, fish, milk, meat liver, and kidney. Also important is that egg ...
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70 Vitamins In Foods: Analysis, Bioavailability, and Stability
https://books.google.com/books?id=vXnLBQAAQBAJ&pg=PA223&lpg=PA223&dq=biotin+pka+value&source=bl&ots=eHamwU-ZkY&sig=ACfU3U20dCG6lJ0uFFAp8vOLFTxVhrJMpQ&hl=en&sa=X&ved=2ahUKEwju8__rltv7AhV8hXIEHXzRCPMQ6AF6BQi4AhAD
The pH of a 0.01% aqueous solution of biotin is 4.5; the pKa value is 4.51. Biotin salts are significantly more water-soluble than the acid form of biotin.
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71 Modeling and Control for Micro/Nano Devices and Systems
https://books.google.com/books?id=yghEDwAAQBAJ&pg=PA22&lpg=PA22&dq=biotin+pka+value&source=bl&ots=ZNK_x177f5&sig=ACfU3U3vVCDXrm_ssCnO5hmX3IkzCwOKqA&hl=en&sa=X&ved=2ahUKEwju8__rltv7AhV8hXIEHXzRCPMQ6AF6BQi3AhAD
The pKa value of biotin is 4.66 [20], so at pH = 7, each biotin molecule carries a net charge of α = 1/(1+104.66–7) ≈ –1q. This result coincides with the ...
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72 Water-soluble Vitamin Assays in Human Nutrition
https://books.google.com/books?id=kn8eBAAAQBAJ&pg=PA55&lpg=PA55&dq=biotin+pka+value&source=bl&ots=IurnCL8sUa&sig=ACfU3U2pIzC4AhdR4rQvfg3glIBLS32lTQ&hl=en&sa=X&ved=2ahUKEwju8__rltv7AhV8hXIEHXzRCPMQ6AF6BQi6AhAD
2.6.2 STRUCTURE The biotin molecule is a fusion of an imidazolidone ring with ... The pH of a 0.01% aqueous solution of biotin is 4.5; the pKa value is 4.51 ...
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73 Handbook of Targeted Delivery of Imaging Agents
https://books.google.com/books?id=Ep23lkiftwIC&pg=PA308&lpg=PA308&dq=biotin+pka+value&source=bl&ots=dC8QDLTQPO&sig=ACfU3U3Xq6VL8_3Nqen1rpxiYD7LhvUWXQ&hl=en&sa=X&ved=2ahUKEwju8__rltv7AhV8hXIEHXzRCPMQ6AF6BQi5AhAD
avidin can be lowered without changing biotin binding activity by chemical ... The deprotonation ratio can be calculated from the pKa value of each amino ...
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74 Biotin - New World Encyclopedia
https://www.newworldencyclopedia.org/entry/biotin
Biotin ; Systematic name ; Chemical formula, C10H16N2O3S ; Molecular weight, 244.31 g/mol ; Other names. Vitamin B · Vitamin H.
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