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1 A systematic review of CXCL13 as a biomarker of disease and ...
https://bmcrheumatol.biomedcentral.com/articles/10.1186/s41927-020-00154-3
The B cell chemoattractant CXCL13 is a promising biomarker in rheumatoid arthritis (RA), with a plausible role in supporting diagnosis, ...
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2 CXCL13 predicts long-term radiographic status in ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/34636880/
In early RA, one single measurement of plasma CXCL13 at baseline is superior ... long-term radiographic status in early rheumatoid arthritis.
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3 CXCL13/CXCR5 axis facilitates endothelial progenitor cell ...
https://www.nature.com/articles/s41419-021-04136-2
We report significantly higher levels of CXCL13 expression in collagen-induced arthritis (CIA) mice compared with controls and also in ...
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4 RETRACTED ARTICLE: Does serum B lymphocyte ...
https://erar.springeropen.com/articles/10.1186/s43166-020-00041-2
Rheumatoid arthritis (RA) affects about 1–3% of the population making ... Serum CXCL13 is correlated with clinical disease activity and MSUS ...
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5 CXCL13 predicts long-term radiographic status in early ...
https://academic.oup.com/rheumatology/article/61/6/2590/6390825
Identification of RA patients at a high risk of joint destruction remains challenging. The C-X-C motif chemokine 13 (CXCL13) has previously been suggested ...
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6 Role of the CXCL13/CXCR5 Axis in Autoimmune Diseases
https://www.frontiersin.org/articles/10.3389/fimmu.2022.850998/full
Recent studies have found that CXCL13 and its receptor CXCR5 are implicated in the pathogenesis of several autoimmune diseases, such as rheumatoid arthritis ...
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7 CXCL13 Serum Levels and Circulating Follicular Helper T ...
https://acrabstracts.org/abstract/cxcl13-serum-levels-and-circulating-follicular-helper-t-cells-decrease-after-co-stimulation-blockade-with-abatacept-in-rheumatoid-arthritis/
CXCL13 Serum Levels and Circulating Follicular Helper T-Cells Decrease After Co-stimulation Blockade with Abatacept in Rheumatoid Arthritis.
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8 THU0546 Serum CXCL13 as A Biomarker of Disease Activity ...
https://ard.bmj.com/content/73/Suppl_2/371.2
THU0546 Serum CXCL13 as A Biomarker of Disease Activity and Severity in IN Rheumatoid Arthritis. Comparison with Acute Phase Reactants and the Autoantibody ...
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9 Correlations between CXCL13, IL-24 genes and wrist arthritis
https://www.europeanreview.org/article/14096
OBJECTIVE: To investigate the relationship between B lymphocyte chemokine 1 (CXCL13) and interleukin-24 (IL-24) gene and wrist arthritis. PATIENTS AND.
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10 A Distinct Human CD4+ T Cell Subset That Secretes CXCL13 ...
https://onlinelibrary.wiley.com/doi/10.1002/art.38173
Objective A subset of CD4+ T cells in the synovium of patients with rheumatoid arthritis (RA) produce CXCL13, a chemokine that is crucial ...
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11 CXCL13-producing PD-1hiCXCR5− helper T cells in chronic ...
https://www.tandfonline.com/doi/full/10.1080/25785826.2020.1781998
CXCL13-producing PD-1hiCXCR5−CD4+ T cells were discovered in synovial tissues of rheumatoid arthritis (RA). Further intensive analysis of ...
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12 Levels of CXCL13 and sICAM-1 correlate with disease activity ...
https://www.scielo.br/j/adr/a/CxMy9W3DWpmhNJ3wJs7Xd5v/?lang=en
Rheumatoid arthritis (RA) is a pathologically heterogeneous disease, with variability between patients in the number of affected joints, antibody titers, serum ...
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13 Clinical significance of serum B cell chemokine (CXCL13) in ...
https://www.sciencedirect.com/science/article/pii/S1110116418300590
Background. The diagnosis of early rheumatoid arthritis (RA) is challenging. B-cell chemokine (CXCL13) plays a critical role in the disease pathogenesis.
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14 CXCL13 is a plasma biomarker of germinal center activity
https://www.pnas.org/doi/10.1073/pnas.1520112113
The CXCL13–CXCR5 [chemokine (C-X-C motif) receptor 5] chemokine axis plays a central ... In rheumatoid arthritis, CXCL13 was not only followed as a plasma ...
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15 Role of CXCL13 and CCL20 in the recruitment of B cells to ...
https://d-nb.info/1164353241/34
Background: B cells exert their pathogenic action in rheumatoid arthritis (RA) locally ... In Transwell experiments, CCL20 and CXCL13, ligands of CCR6 and.
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16 (PDF) A systematic review of CXCL13 as a biomarker of ...
https://www.researchgate.net/publication/345979724_A_systematic_review_of_CXCL13_as_a_biomarker_of_disease_and_treatment_response_in_rheumatoid_arthritis
PDF | Background The B cell chemoattractant CXCL13 is a promising biomarker in rheumatoid arthritis (RA), with a plausible role in supporting diagnosis,.
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17 650.full.pdf - The Journal of Immunology
https://www.jimmunol.org/content/jimmunol/166/1/650.full.pdf
Lymphoid Chemokine B Cell-Attracting Chemokine-1 (CXCL13). Is Expressed in Germinal Center ... Follicles Within the Synovium of Chronic Arthritis Patients.
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18 CXCL13
https://link.springer.com/content/pdf/10.1186/s43166-020-00041-2.pdf
Conclusion: Serum CXCL13 is correlated with clinical disease activity and MSUS ... Keywords: Rheumatoid arthritis, CXCL13 chemokine, Disease activity, ...
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19 Research & Development Programs - Vaccinex
https://www.vaccinex.com/pipeline/research-development-programs/
VX5/5261 neutralizes CXCL13 activity and has been shown to provide therapeutic benefit in mouse models of human autoimmune diseases (e.g. rheumatoid arthritis ...
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20 The correlational research among serum CXCL13 levels, circul...
https://journals.lww.com/md-journal/fulltext/2017/12010/the_correlational_research_among_serum_cxcl13.21.aspx
Differential expression of chemokine receptors on peripheral blood B cells from patients with rheumatoid arthritis and systemic lupus erythematosus.
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21 Targeting the Chemokine System in Rheumatoid Arthritis and ...
https://www.jmaj.jp/detail.php?id=10.31662%2Fjmaj.2020-0019
In addition, CXCL8, CXCL12 and CXCL16 induce angiogenesis in synovial tissue in RA, and CXCL8, CXCL10 and CXCL13 are promising biomarkers of RA ...
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22 CXCR5/CXCL13 pathway, a key driver for migration of ...
https://hal.archives-ouvertes.fr/hal-03326805
The preferential migration of RA B10+ cells toward CXCL13-rich SF was lost ... of regulatory B10 cells, is defective in patients with rheumatoid arthritis.
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23 Monocyte-like and mature macrophages produce CXCL13 (B ...
https://ashpublications.org/blood/article/104/10/3021/18742/Monocyte-like-and-mature-macrophages-produce
The homeostatic chemokine CXCL13 (also called B cell-attracting chemokine 1 ... that most CXCL13-expressing cells in rheumatoid arthritis and ulcerative ...
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24 Association of CXCL10 and CXCL13 levels with disease ...
http://repository.ajou.ac.kr/bitstream/201003/13456/1/26385705.pdf
CXCL13 levels were also determined using an. ELISA kit (R & D Systems) according to the manufacturer's instructions. Han et al. Arthritis Research & Therapy ...
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25 Recombinant Mouse CXCL13 carrier-free - BioLegend
https://www.biolegend.com/en-ie/products/recombinant-mouse-cxcl13-carrier-free-8395?GroupID=GROUP574
CXCL13, CCL19, and CCL21 take part in the formation of tertiary lymphoid tissues in chronic antigen-induced arthritis. High expression of CXCL13 has been linked ...
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26 The CXCL13/CXCR5 Immune Axis in Health and Disease ...
https://www.mdpi.com/2073-4409/11/17/2649/pdf
Abstract: The chemokine C-X-C- ligand 13 (CXCL13) is a major B cell chemoattractant to B ... rheumatoid arthritis (RA), Sjögren's syndrome.
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27 Medline ® Abstract for Reference 81 of 'Pathogenesis of ...
https://www.uptodate.com/contents/pathogenesis-of-sjogrens-syndrome/abstract/81
... Ainsworth J, Mathews J, Salmon M, Bowman SJ, Buckley CD; SO: Arthritis Rheum. ... High levels of BCA-1 (CXCL13) were also found on endothelial cells in ...
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28 Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit DCX130
https://www.rndsystems.com/products/human-cxcl13-blc-bca-1-quantikine-elisa-kit_dcx130
43 References. Quantikine Human CXCL13/BLC/BCA-1 ELISA Kit(DCX130). Sensitivity: 3.97 pg/mL. Validated for Cell Culture Supernates, Serum, EDTA Plasma, ...
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29 Tertiary lymphoid structures induced by CXCL13-producing ...
https://www.biorxiv.org/content/10.1101/2021.12.01.470493.full
Results CXCL13 gene expression correlated with TLS formation and the ... In autoimmune diseases such as rheumatoid arthritis (RA), ...
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30 CXCL13 predicts disease activity in early rheumatoid arthritis ...
https://go.gale.com/ps/i.do?id=GALE%7CA540833600&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=14786354&p=HRCA&sw=w
Baseline CXCL13 plasma levels were increased in early rheumatoid arthritis patients in comparison with healthy volunteers. Also, plasma CXCL13 correlated ...
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31 CXCL13 predicts disease activity in early rheumatoid ... - Pure
https://pure.au.dk/portal/da/publications/cxcl13-predicts-disease-activity-in-early-rheumatoid-arthritis-and-could-be-an-indicator-of-the-therapeutic-window-of-opportunity(10ff30f6-6471-49f5-a57e-f31ba9fa549d).html
C-X-C motif chemokine 13 (CXCL13) is central in this process as it attracts C-X-C chemokine receptor type 5 (CXCR5)-expressing B cells and T follicular helper ...
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32 Type I interferon induces CXCL13 to support ectopic germinal ...
https://rupress.org/jem/article/216/3/621/120349/Type-I-interferon-induces-CXCL13-to-support
CXCR5–CXCL13 signaling drives B cell recruitment to the lung after infection ... insulin-dependent diabetes mellitus, rheumatoid arthritis, ...
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33 Novel Regulators of CXCL13 in Human CD4+ T Cells
https://dash.harvard.edu/handle/1/37365274
Patients with rheumatoid arthritis (RA) may develop T and B cell aggregates capable of generating antibodies locally. CXCL13 levels in RA synovium are ...
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34 Rheumatoid Arthritis: New Insights for the Healthcare ...
https://books.google.com/books?id=HLmGG9ubU78C&pg=PA126&lpg=PA126&dq=cxcl13+arthritis&source=bl&ots=aQ1C4zs5fF&sig=ACfU3U2VmdrAyfRrmzD4RxHWJMzx8BL4VA&hl=en&sa=X&ved=2ahUKEwienbmevdv7AhW9GFkFHS2WB_IQ6AF6BQjNARAD
... La Jolla: CXCL13 - a novel biomarker of B-cell return following rituximab treatment and synovitis in patients with rheumatoid arthritis “Serum ...
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35 CXCL13 | Ligand page
https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=refs&ligandId=3645
CXCL13 expression can be regulated by the lymphotoxin β receptor (LTBR) pathway, ... pathway regulates the interferon signature in rheumatoid arthritis.
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36 Human Sox4 facilitates the development of CXCL13 ...
https://aul.primo.exlibrisgroup.com/discovery/fulldisplay?docid=cdi_doaj_primary_oai_doaj_org_article_dacfc17c85c14dde94e961201bf3b135&context=PC&vid=01AUL_INST:AUL&lang=en&search_scope=MyInst_and_CI&adaptor=Primo%20Central&query=sub%2Cexact%2C%20Interleukin-2%20Receptor%20alpha%20Subunit%20-%20metabolism%20&facet=citedby%2Cexact%2Ccdi_FETCH-LOGICAL-1524t-bd13e52aded012ea9dd4ed30bbb25d75bc65604b32aaf2155db4f806332e433f3&offset=0
... arthritis (RA), and further correlates with ELS formation in RA synovium. Overall, our studies suggest that Sox4 contributes to CXCL13 production and ...
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37 Role of Chemokines and Chemokine Receptors in ...
https://www.dovepress.com/role-of-chemokines-and-chemokine-receptors-in-rheumatoid-arthritis-peer-reviewed-fulltext-article-ITT
Rheumatoid arthritis (RA) is one of the most prevalent autoimmune ... CXCL13 predicts disease activity in early rheumatoid arthritis and ...
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38 Serum CXCL13 Chemokine is Not a Marker for Active Lyme ...
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-1144
The chemokine CXCL13 has been identified as a diagnostic marker for early Lyme ... with antibiotic-responsive and antibiotic-refractory Lyme arthritis.
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39 Changes in expression of serum chemokine CXCL13 and IL-6 ...
https://www.spandidos-publications.com/10.3892/etm.2019.8365/download
CXC ligand 13 (CXCL13) and interleukin-6 (IL-6), and the ... fractures (such as femoral neck fracture), osteoarthritis, bone.
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40 C-X-C Motif Chemokine 13 (CXCL13) Is a Prognostic ...
https://www.atsjournals.org/doi/10.1164/rccm.201309-1592OC
Rationale: C-X-C motif chemokine 13 (CXCL13) mediates B-cell trafficking ... such as systemic lupus erythematosus and rheumatoid arthritis.
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41 To Single Cell Expression Atlas - EMBL-EBI
https://www.ebi.ac.uk/gxa/genes/ENSG00000156234
CXCL13 · 'rheumatoid arthritis' vs 'normal' in 'synovial membrane of synovial joint', cell line, cell type, disease, organism part, stimulus, time ...
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42 Increased circulating CXCL13 levels in systemic lupus ...
https://search.proquest.com/openview/c8db9f20b3e85b729dadfded0e4e0df5/1?pq-origsite=gscholar&cbl=326351
First, CXC ligand 13 (CXCL13) is closely related to the pathogenesis of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), Second, ...
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43 Association of CXCL13 serum level and ultrasonographic ...
https://journals.sagepub.com/doi/abs/10.1177/0961203317753557
In addition, serum level of CXCL13 is associated with disease activity in SLE but does not seem to be a biomarker for arthritis in these patients. Keywords.
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44 CXCL13-producing T FH cells link immune suppression and ...
https://insight.jci.org/articles/view/91487
The phenotype of circulating follicular-helper T cells in patients with rheumatoid arthritis defines CD200 as a potential therapeutic target.
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45 LPA Promotes T Cell Recruitment through Synthesis of CXCL13
https://www.hindawi.com/journals/mi/2015/248492/
Our data highlight that LPA-mediated CXCL13 secretion plays a role in T cell ... Increased CXCL13 production by osteoblasts from osteoarthritis patients in ...
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46 Levels of CXCL13 and sICAM-1 correlate with disease activity ...
https://archive-ouverte.unige.ch/unige:138650
Levels of CXCL13 and sICAM-1 correlate with disease activity score in patients with rheumatoid arthritis treated with tocilizumab. Authors.
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47 Novel CXCL13 transgenic mouse: inflammation drives ...
https://www.oncotarget.com/article/6885/text/
Keywords: chemokine, autoimmunity, thymus, B cells, CXCL13-CXCR5, ... lymphoid follicles within the synovium of chronic arthritis patients.
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48 Levels of CXCL13 and sICAM-1 correlate with ... - ScienceOpen
https://www.scienceopen.com/document?vid=7c70c362-1c28-4a01-8e88-96c6c5fc0234
Correlations between CXCL13 and sICAM-1 levels and Disease Activity Score in 28 ... score in patients with rheumatoid arthritis treated with tocilizumab.
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49 Molecular Portraits of Early Rheumatoid Arthritis Identify ...
https://www.cell.com/cell-reports/pdf/S2211-1247(19)31007-1.pdf
early to established disease in rheumatoid arthritis ... microanatomical analysis of CXCL13 and CCL21 in situ production and pro-.
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50 Synovial cellular and molecular signatures stratify clinical ...
http://eprints.gla.ac.uk/183210/1/183210.pdf
rheumatoid arthritis (ra) patients and determine their ... C-X-C motif-chemokine-13 (CXCL13), interleukin-8 (IL-8) and.
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51 Cytokine biomarkers and the promise of personalized therapy ...
https://www.reumatologiaclinica.org/es-cytokine-biomarkers-promise-personalized-therapy-articulo-S1699258X09000540
Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor ...
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52 Increased Lymphocyte Infiltration in Rheumatoid Arthritis Is ...
https://synapse.koreamed.org/articles/1033395
Finally, CXCL13 expression was higher in RA synovial fluid than in tonsils, but CCL21 expression was comparable in synovial fluid from all ...
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53 BCA-1/CXCL13 expression is associated with CXCR5 ...
https://www.kidney-international.org/article/S0085-2538(15)50622-4/pdf
toid arthritis. We therefore investigated the potential role of. CXCL13 and CXCR5 in formation of B-cell clusters in renal transplant rejection. Methods.
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54 Local Blockade of CCL21 and CXCL13 Signaling as a ... - DTIC
https://apps.dtic.mil/sti/citations/AD1051155
Osteoarthritis OA is characterized by progressive cartilage loss, with resultant joint pain that worsens over time. In the present study, we proposed to ...
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55 Single cell sequencing reveals expanded cytotoxic CD4+ T ...
https://www.medrxiv.org/content/10.1101/2021.05.28.21255902v1.full
Rheumatoid arthritis is an autoimmune disease affecting the synovial ... within the cytotoxic and the CXCL13+ TPH CD4+ T-cell populations.
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56 Association of the CXCL9-CXCR3 and CXCL13-CXCR5 axes ...
https://research.rug.nl/files/175609252/Graver_J_Autoimm_2021.pdf
Boots,. E. Brouwer, Disturbed B cell homeostasis in newly diagnosed giant cell arteritis and polymyalgia rheumatica, Arthritis Rheum. 66 (2014) 1927–1938, https ...
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57 New Insights into Rheumatoid Arthritis, An Issue of ...
https://books.google.com/books?id=S-HkqVBw4IEC&pg=PT242&lpg=PT242&dq=cxcl13+arthritis&source=bl&ots=zCCvd775Ax&sig=ACfU3U0zV25yRP_ajngO1aS4jYmvMI8l8A&hl=en&sa=X&ved=2ahUKEwienbmevdv7AhW9GFkFHS2WB_IQ6AF6BQjBARAD
CXCL13 neutralization reduces the severity of collagen-induced arthritis. Arthritis Rheum. 2005;52(2):620-626. Li J, Turner A, Kuzin I, et al.
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58 Role of CXCL13 and CCL20 in the recruitment of B ... - SUSI
https://susi.usi.ch/rerodoc/326703
Chemokines and chemokine receptors. English Background: B cells exert their pathogenic action in rheumatoid arthritis (RA) locally in the synovium. This study ...
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59 AgeTech and Arthritis: How Technology Can Help ... - YouTube
https://www.youtube.com/watch?v=xwZmAiDgjaU
AGE-WELL NCE
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60 Lupus nephritis: current perspectives and moving forward
https://newsachieve.com/2022/12/02/lupus-nephritis-current-perspectives-and-moving-forward/
... of antibody-mediated disruption of the CXCL13 signaling that is the ... These molecules are commonly used to treat arthritis rheumatoid ...
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