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Google Keyword Rankings for : vitiligo hsp70i
1
HSP70I IS A CRITICAL COMPONENT OF THE IMMUNE ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662798/
Vitiligo is a T cell mediated autoimmune disease of the skin. ... Next, a vitiligo-prone model was used to analyze whether HSP70i alone is ...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662798/
Vitiligo is a T cell mediated autoimmune disease of the skin. ... Next, a vitiligo-prone model was used to analyze whether HSP70i alone is ...
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2
HSP70i Accelerates Depigmentation in a Mouse Model of ...
https://www.sciencedirect.com/science/article/pii/S0022202X15340008
Figure 1. HSP70i is a stress-inducible protein that contributes to vitiligo by activating innate immunity. Mutant HSP70i treats vitiligo by reducing dendritic ...
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https://www.sciencedirect.com/science/article/pii/S0022202X15340008
Figure 1. HSP70i is a stress-inducible protein that contributes to vitiligo by activating innate immunity. Mutant HSP70i treats vitiligo by reducing dendritic ...
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3
HSP70i is back to spotlight as potential therapy for vitiligo
https://vrfoundation.org/news_items/hsp70i-is-back-to-spotlight-as-potential-therapy-for-vitiligo
HSP70i-based therapy for vitiligo is now being developed by Temprian Therapeutics Inc. from Chicago, IL. The company is seeking regulatory approval and funding ...
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https://vrfoundation.org/news_items/hsp70i-is-back-to-spotlight-as-potential-therapy-for-vitiligo
HSP70i-based therapy for vitiligo is now being developed by Temprian Therapeutics Inc. from Chicago, IL. The company is seeking regulatory approval and funding ...
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4
About Temprian
https://tempriantherapeutics.com/about-temprian/
Why does vitiligo occur? When subject to stress, cells in the skin start producing the heat shock protein HSP70i. This protein acts as a messenger that is ...
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https://tempriantherapeutics.com/about-temprian/
Why does vitiligo occur? When subject to stress, cells in the skin start producing the heat shock protein HSP70i. This protein acts as a messenger that is ...
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5
Mutant HSP70 Reverses Autoimmune Depigmentation in Vitiligo
https://www.science.org/doi/abs/10.1126/scitranslmed.3005127?sid=c053657a-926e-427d-92ed-bd8c7f7cfec3
Now, Mosenson et al. suggest that mutant HSP70 could be a potential treatment for autoimmune vitiligo. The authors noticed that mutant inducible HSP70 (HSP70i) ...
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https://www.science.org/doi/abs/10.1126/scitranslmed.3005127?sid=c053657a-926e-427d-92ed-bd8c7f7cfec3
Now, Mosenson et al. suggest that mutant HSP70 could be a potential treatment for autoimmune vitiligo. The authors noticed that mutant inducible HSP70 (HSP70i) ...
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6
A central role for inducible heat‐shock protein 70 in ...
https://onlinelibrary.wiley.com/doi/10.1111/exd.12183
Taken together, targeting HSP70i is a promising approach towards the treatment of vitiligo. Mutant HSP70iQ435A both prevented and reversed the ...
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https://onlinelibrary.wiley.com/doi/10.1111/exd.12183
Taken together, targeting HSP70i is a promising approach towards the treatment of vitiligo. Mutant HSP70iQ435A both prevented and reversed the ...
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7
HSP70i is a critical component of the immune ... - ResearchGate
https://www.researchgate.net/publication/51705061_HSP70i_is_a_critical_component_of_the_immune_response_leading_to_vitiligo
... It has been reported that stressed melanocytes in vitiligo releases heat shock protein, HSP70i, thereby stimulating an innate inflammatory ...
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https://www.researchgate.net/publication/51705061_HSP70i_is_a_critical_component_of_the_immune_response_leading_to_vitiligo
... It has been reported that stressed melanocytes in vitiligo releases heat shock protein, HSP70i, thereby stimulating an innate inflammatory ...
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8
Targeting HSP70 in autoimmune vitiligo - Isabelle Le Poole
https://grantome.com/grant/NIH/R56-AR054749-06A1
Moreover, mutant HSP70i may impact the development of autoimmune disease beyond vitiligo. We propose to generate a manageable peptide of use for patient ...
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https://grantome.com/grant/NIH/R56-AR054749-06A1
Moreover, mutant HSP70i may impact the development of autoimmune disease beyond vitiligo. We propose to generate a manageable peptide of use for patient ...
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9
Modified protein could become first effective treatment for ...
https://www.sciencedaily.com/releases/2013/02/130227150908.htm
Previous studies have found that a protein called HSP70i plays a vital role in the autoimmune response that causes vitiligo. (HSP70i stands ...
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https://www.sciencedaily.com/releases/2013/02/130227150908.htm
Previous studies have found that a protein called HSP70i plays a vital role in the autoimmune response that causes vitiligo. (HSP70i stands ...
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10
Defining a Role for Inducible Heat Shock ... - Loyola eCommons
https://ecommons.luc.edu/cgi/viewcontent.cgi?article=1728&context=luc_diss
Vitiligo melanocytes secrete more HSP70i in response to MBEH. 41. Figure 9. Inducible Hsp70 knockout mice are resistant to depigmentation after.
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https://ecommons.luc.edu/cgi/viewcontent.cgi?article=1728&context=luc_diss
Vitiligo melanocytes secrete more HSP70i in response to MBEH. 41. Figure 9. Inducible Hsp70 knockout mice are resistant to depigmentation after.
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11
Advances in vitiligo: Update on therapeutic targets - Frontiers
https://www.frontiersin.org/articles/10.3389/fimmu.2022.986918/full
4 Cytokine-targeted therapies. Multiple monoclonal antibodies are available for vitiligo treatment, targeting IFN-γ, CXCL10, CXCR3, HSP70i, IL- ...
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https://www.frontiersin.org/articles/10.3389/fimmu.2022.986918/full
4 Cytokine-targeted therapies. Multiple monoclonal antibodies are available for vitiligo treatment, targeting IFN-γ, CXCL10, CXCR3, HSP70i, IL- ...
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12
Evaluating perceived stress and electronic medical record data
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227909
Previous work from our lab showed a critical role of HSP70i from the melanocytes in accelerating autoimmune vitiligo [28, 29].
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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227909
Previous work from our lab showed a critical role of HSP70i from the melanocytes in accelerating autoimmune vitiligo [28, 29].
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13
Targeting HSP70 in autoimmune vitiligo - app.dimension.ai
https://app.dimensions.ai/details/grant/grant.3805109
DESCRIPTION (provided by applicant): We have generated a mutant version of inducible HSP70i with treatment potential for vitiligo.
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https://app.dimensions.ai/details/grant/grant.3805109
DESCRIPTION (provided by applicant): We have generated a mutant version of inducible HSP70i with treatment potential for vitiligo.
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14
HSP70i accelerates depigmentation ... - Northwestern Scholars
https://www.scholars.northwestern.edu/en/publications/hsp70i-accelerates-depigmentation-in-a-mouse-model-of-autoimmune-
Vitiligo is a T-cell-mediated autoimmune disease of the skin. Progressive depigmentation accelerates in response to stress. Personal trauma, contact with ...
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https://www.scholars.northwestern.edu/en/publications/hsp70i-accelerates-depigmentation-in-a-mouse-model-of-autoimmune-
Vitiligo is a T-cell-mediated autoimmune disease of the skin. Progressive depigmentation accelerates in response to stress. Personal trauma, contact with ...
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15
MUTANT HSP70i TO PREVENT AUTOIMMUNE DISEASE
https://patents.google.com/patent/WO2013033395A1/en
Under stressful conditions, secreted, HSP70i is believed to serve as an adjuvant in Vitiligo, binding melanocytic antigens to be processed by antigen presenting ...
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https://patents.google.com/patent/WO2013033395A1/en
Under stressful conditions, secreted, HSP70i is believed to serve as an adjuvant in Vitiligo, binding melanocytic antigens to be processed by antigen presenting ...
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16
Update on the pathogenesis of vitiligo
http://www.anaisdedermatologia.org.br/en-update-on-pathogenesis-vitiligo-articulo-S0365059622000654
Vitiligo is a complex disease whose pathogenesis results from the interaction ... HSP70i is a critical component of the immune response leading to vitiligo.
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http://www.anaisdedermatologia.org.br/en-update-on-pathogenesis-vitiligo-articulo-S0365059622000654
Vitiligo is a complex disease whose pathogenesis results from the interaction ... HSP70i is a critical component of the immune response leading to vitiligo.
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17
Temprian Therapeutics - Twitter
https://twitter.com/temprian?lang=en
Temprian Therapeutics is developing a new way to treat vitiligo by injecting DNA coding for a modified heat shock protein HSP70i to stop the autoimmune ...
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https://twitter.com/temprian?lang=en
Temprian Therapeutics is developing a new way to treat vitiligo by injecting DNA coding for a modified heat shock protein HSP70i to stop the autoimmune ...
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18
Pathogenesis and the emerging Therapy of ... - Fortune Journals
https://www.fortunejournals.com/articles/pathogenesis-and-the-emerging-therapy-of-vitiligo.html
HSP70i - group reported the role of heat shock protein HSP70i in the pathogenesis of vitiligo, suggesting that heat shock protein HSP70i is released by ...
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https://www.fortunejournals.com/articles/pathogenesis-and-the-emerging-therapy-of-vitiligo.html
HSP70i - group reported the role of heat shock protein HSP70i in the pathogenesis of vitiligo, suggesting that heat shock protein HSP70i is released by ...
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19
HSP70i | New Drug Approvals
https://newdrugapprovals.org/tag/hsp70i/
WEDNESDAY Feb. 27, 2013 — A genetically modified protein could provide the first effective treatment for the skin condition vitiligo, a new study in mice ...
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https://newdrugapprovals.org/tag/hsp70i/
WEDNESDAY Feb. 27, 2013 — A genetically modified protein could provide the first effective treatment for the skin condition vitiligo, a new study in mice ...
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20
I. Caroline Le Poole Inventions, Patents and Patent Applications
https://patents.justia.com/inventor/i-caroline-le-poole
MUTANT HSP70i TO PREVENT AUTOIMMUNE DISEASE. Publication number: 20210024599. Abstract: Methods of treating autoimmune diseases, such as vitiligo, ...
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https://patents.justia.com/inventor/i-caroline-le-poole
MUTANT HSP70i TO PREVENT AUTOIMMUNE DISEASE. Publication number: 20210024599. Abstract: Methods of treating autoimmune diseases, such as vitiligo, ...
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21
Vitiligo, From Physiopathology to Emerging Treatments
https://link.springer.com/article/10.1007/s13555-020-00447-y
To date, HSP70i seems to be a critical component in the initiation of the disease. HSP70i is overexpressed in vitiliginous skin compared to ...
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https://link.springer.com/article/10.1007/s13555-020-00447-y
To date, HSP70i seems to be a critical component in the initiation of the disease. HSP70i is overexpressed in vitiliginous skin compared to ...
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22
Northwestern University Licenses Promising Autoimmune ...
https://www.prweb.com/releases/northwestern_university_licenses_promising_autoimmune_technology_to_temprian_therapeutics/prweb16731402.htm
Vitiligo is a familial disease typically triggered by stress. The stress causes affected cells to express HSP70i, a heat shock protein that ...
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https://www.prweb.com/releases/northwestern_university_licenses_promising_autoimmune_technology_to_temprian_therapeutics/prweb16731402.htm
Vitiligo is a familial disease typically triggered by stress. The stress causes affected cells to express HSP70i, a heat shock protein that ...
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23
Vitiligo's Emerging Drug Pipeline - Dermatology Times
https://www.dermatologytimes.com/view/vitiligo-s-emerging-drug-pipeline
Ruxolitinib cream 1.5% may soon be the first FDA-approved treatment for repigmentation of vitiligo. Experts share what dermatologists need ...
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https://www.dermatologytimes.com/view/vitiligo-s-emerging-drug-pipeline
Ruxolitinib cream 1.5% may soon be the first FDA-approved treatment for repigmentation of vitiligo. Experts share what dermatologists need ...
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24
Protein HSP70i - Vitiligo Zone
https://www.vitiligozone.com/research-studies/hsp70i-protein
The mutant HSP70i protein supplants HSP70i proteins, reversing the autoimmune response in vitiligo. When administered to mice, HSP70i protein ...
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https://www.vitiligozone.com/research-studies/hsp70i-protein
The mutant HSP70i protein supplants HSP70i proteins, reversing the autoimmune response in vitiligo. When administered to mice, HSP70i protein ...
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25
The Promising Role of Chemokines in Vitiligo: From Oxidative ...
https://www.hindawi.com/journals/omcl/2022/8796735/
Vitiligo is a common chronic autoimmune skin disorder featured with depigmented ... The interplay between inducible HSP70i and plasmacytoid dendritic cells ...
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https://www.hindawi.com/journals/omcl/2022/8796735/
Vitiligo is a common chronic autoimmune skin disorder featured with depigmented ... The interplay between inducible HSP70i and plasmacytoid dendritic cells ...
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26
Recent Progress and Future Directions: The Nano-Drug ...
https://www.dovepress.com/recent-progress-and-future-directions-the-nano-drug-delivery-system-fo-peer-reviewed-fulltext-article-IJN
Keywords: vitiligo, nano-drug delivery system, ... HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo.
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https://www.dovepress.com/recent-progress-and-future-directions-the-nano-drug-delivery-system-fo-peer-reviewed-fulltext-article-IJN
Keywords: vitiligo, nano-drug delivery system, ... HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo.
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27
Update on the pathogenesis of vitiligo - SciELO
https://www.scielo.br/j/abd/a/rGFjzRRxSLpMJ7y8Cxdz9HD/
Vitiligo is a complex disease whose pathogenesis results from the interaction ... HSP70i is a critical component of the immune response leading to vitiligo.
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https://www.scielo.br/j/abd/a/rGFjzRRxSLpMJ7y8Cxdz9HD/
Vitiligo is a complex disease whose pathogenesis results from the interaction ... HSP70i is a critical component of the immune response leading to vitiligo.
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28
MUTANT HSP70i TO PREVENT AUTOIMMUNE DISEASE
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2013033395
A vaccine and method of treatment suitable for treating autoimmune diseases, such as Vitiligo, by using variant peptides representing a sequence of amino ...
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https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2013033395
A vaccine and method of treatment suitable for treating autoimmune diseases, such as Vitiligo, by using variant peptides representing a sequence of amino ...
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29
HSP70i is a critical component of the immune ... - OA.mg
https://oa.mg/work/10.4016/39524.01
Read and download HSP70i is a critical component of the immune response leading to vitiligo by Jeffrey Mosenson, Andrew Zloza, Jared Klarquist, ...
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https://oa.mg/work/10.4016/39524.01
Read and download HSP70i is a critical component of the immune response leading to vitiligo by Jeffrey Mosenson, Andrew Zloza, Jared Klarquist, ...
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30
Pathogenesis and the emerging Therapy of ... - Fortune Journals
http://fortunepublish.com/articles/10.26502.acbr.50170080.pdf
that vitiligo is also an autoimmune disease [6]. These ... HSP70i in the pathogenesis of vitiligo, suggesting that heat shock protein HSP70i ...
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http://fortunepublish.com/articles/10.26502.acbr.50170080.pdf
that vitiligo is also an autoimmune disease [6]. These ... HSP70i in the pathogenesis of vitiligo, suggesting that heat shock protein HSP70i ...
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31
Summary of the vitiligo patient meeting in Orange, CA on 09 ...
https://www.umassmed.edu/vitiligo/blog/blog-posts1/2015/10/summary-of-the-vitiligo-patient-meeting-in-orange-ca-on-september-27th-2015/
She found that the stress protein HSP70i is increased in affected skin from vitiligo patients, and that mice without that protein were ...
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https://www.umassmed.edu/vitiligo/blog/blog-posts1/2015/10/summary-of-the-vitiligo-patient-meeting-in-orange-ca-on-september-27th-2015/
She found that the stress protein HSP70i is increased in affected skin from vitiligo patients, and that mice without that protein were ...
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32
COVID‐19 and autoimmune phenomena: Vitiligo after ...
https://www.vipoc.org/covid%E2%80%9019-and-autoimmune-phenomena-vitiligo-after-astrazeneca-vaccine/
Various studies have proven the central role that HSP70i plays in the pathogenesis of vitiligo, since its overexpression is associated with ...
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https://www.vipoc.org/covid%E2%80%9019-and-autoimmune-phenomena-vitiligo-after-astrazeneca-vaccine/
Various studies have proven the central role that HSP70i plays in the pathogenesis of vitiligo, since its overexpression is associated with ...
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33
Defining a Role for Inducible Heat Shock Protein 70 (HSP70i ...
https://www.semanticscholar.org/paper/Defining-a-role-for-inducible-heat-shock-protein-70-Mosenson/1dd4dbcc37887c41dad1846681c1329532cd2ccb/figure/7
... of optimized TRP-1 and HSP70i and imaged 4 weeks after the final vaccination. ... Inducible Heat Shock Protein 70 (HSP70i) In Mediating Autoimmune Vitiligo"
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https://www.semanticscholar.org/paper/Defining-a-role-for-inducible-heat-shock-protein-70-Mosenson/1dd4dbcc37887c41dad1846681c1329532cd2ccb/figure/7
... of optimized TRP-1 and HSP70i and imaged 4 weeks after the final vaccination. ... Inducible Heat Shock Protein 70 (HSP70i) In Mediating Autoimmune Vitiligo"
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34
Synthetic drugs for the treatment of vitiligo: a patent review ...
https://www.tandfonline.com/doi/abs/10.1080/13543776.2016.1215434
Introduction: Vitiligo is one of the most important acquired ... and their patent treatment for vitiligo with a mutant HSP70i that works like an ...
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https://www.tandfonline.com/doi/abs/10.1080/13543776.2016.1215434
Introduction: Vitiligo is one of the most important acquired ... and their patent treatment for vitiligo with a mutant HSP70i that works like an ...
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35
Vitiligo Drugs Market Is Expected Significant Growth, Forecast ...
https://www.medgadget.com/2022/05/according-to-the-latest-report-vitiligo-drugs-market-is-expected-significant-growth-forecast-from-2022-to-2028-dermavant-sciences-inc-incyte-corporation-aclaris-therapeutics-inc-dr-reddy.html
... and market-concerned with therapy for vitiligo. The HSP70i-founded medicine is modified to strike gut, obstructs the expansion of the ...
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https://www.medgadget.com/2022/05/according-to-the-latest-report-vitiligo-drugs-market-is-expected-significant-growth-forecast-from-2022-to-2028-dermavant-sciences-inc-incyte-corporation-aclaris-therapeutics-inc-dr-reddy.html
... and market-concerned with therapy for vitiligo. The HSP70i-founded medicine is modified to strike gut, obstructs the expansion of the ...
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36
Vitiligo skin disorder and gray hair treatment may improve ...
https://www.belmarrahealth.com/vitiligo-skin-disorder-and-gray-hair-treatment-may-improve-from-modified-protein-study/
Previous studies found that a protein called HSP70i plays a vital role in the autoimmune response that causes vitiligo. HSP70i consists of ...
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https://www.belmarrahealth.com/vitiligo-skin-disorder-and-gray-hair-treatment-may-improve-from-modified-protein-study/
Previous studies found that a protein called HSP70i plays a vital role in the autoimmune response that causes vitiligo. HSP70i consists of ...
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37
Handbook of Vitiligo: Basic Science and Clinical Management
https://books.google.com/books?id=Dm-fCwAAQBAJ&pg=PA28&lpg=PA28&dq=vitiligo+hsp70i&source=bl&ots=QrQGsEs5Fp&sig=ACfU3U1W8fCcA5r3mERQklnvH1o-Lo-HKw&hl=en&sa=X&ved=2ahUKEwiouKOY5Nz7AhUYlWoFHTYQDdsQ6AF6BQi8AhAD
HSP70i was released into the cell culture media and induced the activation of ... its role in activating dendritic cells and contributing to vitiligo ...
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https://books.google.com/books?id=Dm-fCwAAQBAJ&pg=PA28&lpg=PA28&dq=vitiligo+hsp70i&source=bl&ots=QrQGsEs5Fp&sig=ACfU3U1W8fCcA5r3mERQklnvH1o-Lo-HKw&hl=en&sa=X&ved=2ahUKEwiouKOY5Nz7AhUYlWoFHTYQDdsQ6AF6BQi8AhAD
HSP70i was released into the cell culture media and induced the activation of ... its role in activating dendritic cells and contributing to vitiligo ...
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38
Vitiligo - References | BMJ Best Practice US
https://bestpractice.bmj.com/topics/en-us/628/references
HSP70i is a critical component of the immune response leading to vitiligo. Pigment Cell Melanoma Res. 2012 Jan;25(1):88-98.Full text Abstract.
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https://bestpractice.bmj.com/topics/en-us/628/references
HSP70i is a critical component of the immune response leading to vitiligo. Pigment Cell Melanoma Res. 2012 Jan;25(1):88-98.Full text Abstract.
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39
Targeting Innate Immunity to Combat Cutaneous Stress
https://www.cure-vitiligo.com/docs/fimmu-12-613056.pdf
Likewise, modified HSP70i prevented or reversed vitiligo in a mouse and Sinclair Swine models of the disease (21, 22). In.
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https://www.cure-vitiligo.com/docs/fimmu-12-613056.pdf
Likewise, modified HSP70i prevented or reversed vitiligo in a mouse and Sinclair Swine models of the disease (21, 22). In.
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40
Study to Evaluate Adverse Events and Change in Disease ...
https://clinicaltrials.gov/ct2/show/NCT04927975
Adverse effects and change in disease activity will be assessed. Upadacitinib is being evaluated for the treatment of non-segmental vitiligo.
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https://clinicaltrials.gov/ct2/show/NCT04927975
Adverse effects and change in disease activity will be assessed. Upadacitinib is being evaluated for the treatment of non-segmental vitiligo.
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41
(PDF) HSP70i Accelerates Depigmentation in a Mouse Model ...
https://www.academia.edu/8458847/HSP70i_Accelerates_Depigmentation_in_a_Mouse_Model_of_Autoimmune_Vitiligo
Vaccination with a recombinant vaccinia virus encoding a 'self' antigen induces autoimmune vitiligo and tumor cell destruction in mice: Requirement for CD4+ ...
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https://www.academia.edu/8458847/HSP70i_Accelerates_Depigmentation_in_a_Mouse_Model_of_Autoimmune_Vitiligo
Vaccination with a recombinant vaccinia virus encoding a 'self' antigen induces autoimmune vitiligo and tumor cell destruction in mice: Requirement for CD4+ ...
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42
Mutant Heat Shock Protein Vaccine Prevents Vitiligo in Mouse ...
https://www.labmedica.com/bioresearch/articles/294745115/mutant-heat-shock-protein-vaccine-prevents-vitiligo-in-mouse-model.html
Image: Vitiligo mice after vaccination with mutant HSP70i protein (Photo courtesy of Loyola University Chicago Stritch School of Medicine).
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https://www.labmedica.com/bioresearch/articles/294745115/mutant-heat-shock-protein-vaccine-prevents-vitiligo-in-mouse-model.html
Image: Vitiligo mice after vaccination with mutant HSP70i protein (Photo courtesy of Loyola University Chicago Stritch School of Medicine).
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43
Jose Alejandro Guevara, MD, PhD - Moffitt Cancer Center
https://moffitt.org/research-science/researchers/jose-alejandro-guevara/
HSP70i is a critical component of the immune response leading to vitiligo. Pigment Cell Melanoma Res. 2012 Jan.25(1):88-98. Pubmedid: 21978301.
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https://moffitt.org/research-science/researchers/jose-alejandro-guevara/
HSP70i is a critical component of the immune response leading to vitiligo. Pigment Cell Melanoma Res. 2012 Jan.25(1):88-98. Pubmedid: 21978301.
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44
Pathogenesis of vitiligo. Autoimmune theory - Medigraphic
https://www.medigraphic.com/cgi-bin/new/resumenI.cgi?IDARTICULO=99918
Taieb A. Vitiligo as an inflammatory skin disorder: a therapeutic perspective. ... HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo ...
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https://www.medigraphic.com/cgi-bin/new/resumenI.cgi?IDARTICULO=99918
Taieb A. Vitiligo as an inflammatory skin disorder: a therapeutic perspective. ... HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo ...
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45
Pathogenesis of vitiligo
https://jkma.org/m/journal/view.php?number=3175
Vitiligo is an autoimmune disease in which CD8+ T-cells target and destroy melanocytes, leaving areas of skin without pigment production.
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https://jkma.org/m/journal/view.php?number=3175
Vitiligo is an autoimmune disease in which CD8+ T-cells target and destroy melanocytes, leaving areas of skin without pigment production.
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46
DNA injection could cure vitiligo
https://thevitpro.com/dna-injection-could-cure-vitiligo/
This research stems from the discovery that HSP70i, a protein that results from stressed melanocytes, accelerates depigmentation in vitiligo.
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https://thevitpro.com/dna-injection-could-cure-vitiligo/
This research stems from the discovery that HSP70i, a protein that results from stressed melanocytes, accelerates depigmentation in vitiligo.
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47
Lab Notes: Vitiligo Put on the Spot | MedPage Today
https://www.medpagetoday.com/labnotes/labnotes/37622
The researchers had previously showed that the inducible heat shock protein 70 (HSP70i) plays a central role in the loss of pigment, by ...
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https://www.medpagetoday.com/labnotes/labnotes/37622
The researchers had previously showed that the inducible heat shock protein 70 (HSP70i) plays a central role in the loss of pigment, by ...
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48
Advances in Hypopigmentation Research and Treatment: 2012 ...
https://books.google.com/books?id=HWktLpRjLXgC&pg=PA9&lpg=PA9&dq=vitiligo+hsp70i&source=bl&ots=7tiyWP49_R&sig=ACfU3U1mWH142XiesJQBaLysnVpw9STpnQ&hl=en&sa=X&ved=2ahUKEwiouKOY5Nz7AhUYlWoFHTYQDdsQ6AF6BQizAhAD
vitiligo. “HSP70i and other stress proteins have been used in anti-tumor vaccines. This begs the question whether HSP70i plays a unique role in immune ...
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https://books.google.com/books?id=HWktLpRjLXgC&pg=PA9&lpg=PA9&dq=vitiligo+hsp70i&source=bl&ots=7tiyWP49_R&sig=ACfU3U1mWH142XiesJQBaLysnVpw9STpnQ&hl=en&sa=X&ved=2ahUKEwiouKOY5Nz7AhUYlWoFHTYQDdsQ6AF6BQizAhAD
vitiligo. “HSP70i and other stress proteins have been used in anti-tumor vaccines. This begs the question whether HSP70i plays a unique role in immune ...
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49
Targeting Innate Immunity to Combat Cutaneous Stress - Papers
https://www.readcube.com/articles/10.3389/fimmu.2021.613056
Vitiligo is defined by the loss of epidermal melanocytes, ... Likewise, modified HSP70i prevented or reversed vitiligo in a
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https://www.readcube.com/articles/10.3389/fimmu.2021.613056
Vitiligo is defined by the loss of epidermal melanocytes, ... Likewise, modified HSP70i prevented or reversed vitiligo in a
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50
Effective Treatment for Vitiligo Skin Disorder Identified
https://www.medindia.net/news/effective-treatment-for-vitiligo-skin-disorder-identified-115009-1.htm
Previous studies have found that a protein called HSP70i plays a vital role in the autoimmune response that causes vitiligo.
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https://www.medindia.net/news/effective-treatment-for-vitiligo-skin-disorder-identified-115009-1.htm
Previous studies have found that a protein called HSP70i plays a vital role in the autoimmune response that causes vitiligo.
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51
Caroline Le Poole will be... - Temprian Therapeutics - Facebook
https://www.facebook.com/TemprianTherapeutics/posts/caroline-le-poole-will-be-presenting-hsp70i-based-treatment-of-vitiligo-in-this-/652436835221428/
Caroline Le Poole will be presenting HSP70I, based treatment of #vitiligo in this year's #Science2Startup! This event connects therapeutics ...
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https://www.facebook.com/TemprianTherapeutics/posts/caroline-le-poole-will-be-presenting-hsp70i-based-treatment-of-vitiligo-in-this-/652436835221428/
Caroline Le Poole will be presenting HSP70I, based treatment of #vitiligo in this year's #Science2Startup! This event connects therapeutics ...
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52
T-cell skin trafficking in patients with vitiligo through CXCL16 ...
https://www.jacionline.org/article/S0091-6749%2816%2931277-5/pdf
Vitiligo is an autoimmune skin disease characterized by progres- ... HSP70i is a critical component of the immune response leading to vitiligo.
→ Check Latest Keyword Rankings ←
https://www.jacionline.org/article/S0091-6749%2816%2931277-5/pdf
Vitiligo is an autoimmune skin disease characterized by progres- ... HSP70i is a critical component of the immune response leading to vitiligo.
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53
HSP70i is a critical component of the immune ... - YouTube
https://www.youtube.com/watch?v=-vt_xO2rraQ
author Jeffrey A. Mosenson on the subject of HSp70i is a critical component ... component of the immune response leading to vitiligo | SciV.
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https://www.youtube.com/watch?v=-vt_xO2rraQ
author Jeffrey A. Mosenson on the subject of HSp70i is a critical component ... component of the immune response leading to vitiligo | SciV.
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54
Vitiligo - The Lancet
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60763-7/fulltext
Vitiligo is an acquired chronic depigmenting disorder of the skin ... HSP70i is a critical component of the immune response leading to ...
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https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60763-7/fulltext
Vitiligo is an acquired chronic depigmenting disorder of the skin ... HSP70i is a critical component of the immune response leading to ...
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55
Patho-immunological mechanisms of vitiligo - Authorea
https://d197for5662m48.cloudfront.net/documents/publicationstatus/61036/preprint_pdf/c3ce79be36b9aa5d6ea34839399482ad.pdf
Therefore, delivery of mutant HSP70i may offer a potential treatment for vitiligo by altering the innate immunity.
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https://d197for5662m48.cloudfront.net/documents/publicationstatus/61036/preprint_pdf/c3ce79be36b9aa5d6ea34839399482ad.pdf
Therefore, delivery of mutant HSP70i may offer a potential treatment for vitiligo by altering the innate immunity.
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56
Kanneganti Murthy, PhD - Lakewood-Amedex, Inc.
https://lakewoodamedex.com/about-lakewood-amedex/kanneganti-murthy/
... programs to treat lung inhalation toxicity (antioxidants), multiple sclerosis (CXCL11), glaucoma (K-ATP channel modulator), and vitiligo (HSP70i).
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https://lakewoodamedex.com/about-lakewood-amedex/kanneganti-murthy/
... programs to treat lung inhalation toxicity (antioxidants), multiple sclerosis (CXCL11), glaucoma (K-ATP channel modulator), and vitiligo (HSP70i).
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57
Pathogenesis and the emerging Therapy of ... - Fortune Journals
https://fortuneonline.org/articles/pathogenesis-and-the-emerging-therapy-of-vitiligo.html
Vitiligo is a common and a disfiguring autoimmune disease, ... Recently, HSP70i has been shown to play an important role in the pathogenesis of vitiligo in ...
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https://fortuneonline.org/articles/pathogenesis-and-the-emerging-therapy-of-vitiligo.html
Vitiligo is a common and a disfiguring autoimmune disease, ... Recently, HSP70i has been shown to play an important role in the pathogenesis of vitiligo in ...
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58
Chicago researchers find cure for Vitiligo skin condition
https://www.firstpost.com/living/chicago-researchers-find-cure-for-vitiligo-skin-condition-641214.html
According to the Mumbai Mirror, the group of researchers have created a 'mutant' version of the HSP70i protein, which previous studies have ...
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https://www.firstpost.com/living/chicago-researchers-find-cure-for-vitiligo-skin-condition-641214.html
According to the Mumbai Mirror, the group of researchers have created a 'mutant' version of the HSP70i protein, which previous studies have ...
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59
Current Concepts of Vitiligo Immunopathogenesis - MDPI
https://www.mdpi.com/2227-9059/10/7/1639/htm
Given its autoimmune background, vitiligo is frequently associated with other ... Following the recognition of DAMPs, such as HSP70i, DCs release high ...
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https://www.mdpi.com/2227-9059/10/7/1639/htm
Given its autoimmune background, vitiligo is frequently associated with other ... Following the recognition of DAMPs, such as HSP70i, DCs release high ...
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60
Temprian Therapeutics - Crowdfunding for Small Businesses
https://www.fundable.com/temprian-therapeutics
By directly injecting into the skin, DNA coding for a modified heat shock protein HSP70i, we stop the autoimmune response and reverse vitiligo.
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https://www.fundable.com/temprian-therapeutics
By directly injecting into the skin, DNA coding for a modified heat shock protein HSP70i, we stop the autoimmune response and reverse vitiligo.
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61
Vitiligo - Page 214 - Google Books Result
https://books.google.com/books?id=vc6kDwAAQBAJ&pg=PA214&lpg=PA214&dq=vitiligo+hsp70i&source=bl&ots=CpehuoYpKq&sig=ACfU3U19C-aq6cyFiruyfEcWwnVbXWeKyA&hl=en&sa=X&ved=2ahUKEwiouKOY5Nz7AhUYlWoFHTYQDdsQ6AF6BQiyAhAD
melanoma where vitiligo was observed as a side effect of immunotherapy. ... Inclusion of HSP70i, independent of origin, was found to accelerate ...
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https://books.google.com/books?id=vc6kDwAAQBAJ&pg=PA214&lpg=PA214&dq=vitiligo+hsp70i&source=bl&ots=CpehuoYpKq&sig=ACfU3U19C-aq6cyFiruyfEcWwnVbXWeKyA&hl=en&sa=X&ved=2ahUKEwiouKOY5Nz7AhUYlWoFHTYQDdsQ6AF6BQiyAhAD
melanoma where vitiligo was observed as a side effect of immunotherapy. ... Inclusion of HSP70i, independent of origin, was found to accelerate ...
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62
Temprian Therapeutics | Tracxn
https://tracxn.com/d/companies/tempriantherapeutics.com
Founded in the year 2019 · Developer of drugs for treating vitiligo. ... The company is using modified heat shock protein HSP70i to treat vitiligo by ...
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https://tracxn.com/d/companies/tempriantherapeutics.com
Founded in the year 2019 · Developer of drugs for treating vitiligo. ... The company is using modified heat shock protein HSP70i to treat vitiligo by ...
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63
WO2013033395A1.pdf
https://patentimages.storage.googleapis.com/07/47/ad/a5ce7b35a56fd3/WO2013033395A1.pdf
for treating autoimmune diseases, such as Vitiligo, by using ... inducing autoimmunity in Vitiligo, in vivo studies have shown that HSP70i.
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https://patentimages.storage.googleapis.com/07/47/ad/a5ce7b35a56fd3/WO2013033395A1.pdf
for treating autoimmune diseases, such as Vitiligo, by using ... inducing autoimmunity in Vitiligo, in vivo studies have shown that HSP70i.
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64
pacientes con vitiligo: Topics by Science.gov
https://www.science.gov/topicpages/p/pacientes+con+vitiligo
Vitiligo is the most common depigmentary disorder of the skin and hair, ... However, vitiligo melanocytes secreted increased amounts of HSP70i in response ...
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https://www.science.gov/topicpages/p/pacientes+con+vitiligo
Vitiligo is the most common depigmentary disorder of the skin and hair, ... However, vitiligo melanocytes secreted increased amounts of HSP70i in response ...
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65
Co-occurrence of Psoriasis, Vitiligo, and Lichen Planus in a...
https://journals.lww.com/ijpd/Fulltext/2018/19020/Co_occurrence_of_Psoriasis,_Vitiligo,_and_Lichen.23.aspx
The disease has an autoimmune and complex genetic background. It may be associated with other autoimmune diseases such as vitiligo, lichen planus, discoid lupus ...
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https://journals.lww.com/ijpd/Fulltext/2018/19020/Co_occurrence_of_Psoriasis,_Vitiligo,_and_Lichen.23.aspx
The disease has an autoimmune and complex genetic background. It may be associated with other autoimmune diseases such as vitiligo, lichen planus, discoid lupus ...
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66
A mouse model of vitiligo based on endogenous auto-reactive ...
https://cellregeneration.springeropen.com/articles/10.1186/s13619-022-00132-9
HSP70i is a critical component of the immune response leading to vitiligo. Pigment Cell Melanoma Res. 2012;25:88–98.
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https://cellregeneration.springeropen.com/articles/10.1186/s13619-022-00132-9
HSP70i is a critical component of the immune response leading to vitiligo. Pigment Cell Melanoma Res. 2012;25:88–98.
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67
Research | Mysite - The Le Poole Lab
https://www.lepoolelab.com/research
In the autoimmune condition vitiligo, the goal is to reduce the immune response that affects the livelihood of melanocytes, responsible for generating pigment ...
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https://www.lepoolelab.com/research
In the autoimmune condition vitiligo, the goal is to reduce the immune response that affects the livelihood of melanocytes, responsible for generating pigment ...
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68
Recent advances in understanding vitiligo - F1000Research
https://f1000research.com/articles/5-2234
Vitiligo, an acquired depigmentation disorder, manifests as white macules on the skin and can cause significant psychological stress and stigmatization.
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https://f1000research.com/articles/5-2234
Vitiligo, an acquired depigmentation disorder, manifests as white macules on the skin and can cause significant psychological stress and stigmatization.
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69
HSP70i Q435A- 辛克莱猪中编码DNA色素白癜风的病变 - X-MOL
https://www.x-mol.com/paper/748270
The underlying DNA was used to prevent and treat disease in vitiligo mouse models through reduced dendritic cell activation and diminished ...
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https://www.x-mol.com/paper/748270
The underlying DNA was used to prevent and treat disease in vitiligo mouse models through reduced dendritic cell activation and diminished ...
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70
Vitiligo: Medical and Surgical Management - Google Books Result
https://books.google.com/books?id=I5xODwAAQBAJ&pg=PT81&lpg=PT81&dq=vitiligo+hsp70i&source=bl&ots=VA0qEkyXh9&sig=ACfU3U074TKqh87QjDkuZ0OdKKCVhnrMuQ&hl=en&sa=X&ved=2ahUKEwiouKOY5Nz7AhUYlWoFHTYQDdsQ6AF6BQitAhAD
When HSP70i‐deficient mice were exposed to a vitiligo induction protocol, they failed to develop robust depigmentation, suggesting its presence is required ...
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https://books.google.com/books?id=I5xODwAAQBAJ&pg=PT81&lpg=PT81&dq=vitiligo+hsp70i&source=bl&ots=VA0qEkyXh9&sig=ACfU3U074TKqh87QjDkuZ0OdKKCVhnrMuQ&hl=en&sa=X&ved=2ahUKEwiouKOY5Nz7AhUYlWoFHTYQDdsQ6AF6BQitAhAD
When HSP70i‐deficient mice were exposed to a vitiligo induction protocol, they failed to develop robust depigmentation, suggesting its presence is required ...
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71
Vitiligo Drugs Market Size, Trends And Forecast To 2026
https://www.coherentmarketinsights.com/market-insight/vitiligo-drugs-market-2447
[195] Vitiligo Drugs Market to reach US$ 348.3 Mn by 2027. ... The HSP70i-based drug is designed to slowdown autoimmunity, stops the spread of the disease, ...
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https://www.coherentmarketinsights.com/market-insight/vitiligo-drugs-market-2447
[195] Vitiligo Drugs Market to reach US$ 348.3 Mn by 2027. ... The HSP70i-based drug is designed to slowdown autoimmunity, stops the spread of the disease, ...
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72
Heat shock protein-70 expression in vitiligo and its relation to ...
https://e-ijd.org/article.asp?issn=0019-5154;year=2016;volume=61;issue=4;spage=408;epage=412;aulast=Doss;type=3
Vitiligo patients were divided as regards to the disease activity into highly ... HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo.
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https://e-ijd.org/article.asp?issn=0019-5154;year=2016;volume=61;issue=4;spage=408;epage=412;aulast=Doss;type=3
Vitiligo patients were divided as regards to the disease activity into highly ... HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo.
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73
The relationship between stress and vitiligo - APA PsycNet
https://psycnet.apa.org/record/2021-20490-001
HSP70i is a critical component of the immune response leading to vitiligo. Pigment Cell Melanoma Res. 2012; 25(1):88-98.
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https://psycnet.apa.org/record/2021-20490-001
HSP70i is a critical component of the immune response leading to vitiligo. Pigment Cell Melanoma Res. 2012; 25(1):88-98.
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74
Vitiligo – A Complex Autoimmune Skin Depigmenting Disease
https://www.intechopen.com/chapters/47867
HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo. J Invest Dermatol 2008;128: 2041-2048. 99. Basak PY, Adiloglu AK, ...
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https://www.intechopen.com/chapters/47867
HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo. J Invest Dermatol 2008;128: 2041-2048. 99. Basak PY, Adiloglu AK, ...
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75
definition of HSP70I by Medical dictionary
https://medical-dictionary.thefreedictionary.com/HSP70I
Previous studies have found that a protein called HSP70i plays a vital role in the autoimmune response that causes vitiligo. HSP70i consists of 641 building ...
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https://medical-dictionary.thefreedictionary.com/HSP70I
Previous studies have found that a protein called HSP70i plays a vital role in the autoimmune response that causes vitiligo. HSP70i consists of 641 building ...
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76
Replenishing Regulatory T Cells to Halt Depigmentation in ...
https://www.jidsponline.org/article/S1087-0024(16)30074-0/fulltext
We studied immune cells infiltrating vitiligo skin and found very few ... HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo.
→ Check Latest Keyword Rankings ←
https://www.jidsponline.org/article/S1087-0024(16)30074-0/fulltext
We studied immune cells infiltrating vitiligo skin and found very few ... HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo.
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77
Management of patients with vitiligo | GPonline
https://www.gponline.com/management-patients-vitiligo/dermatology/article/1373737
Psychological support is an important part of managing vitiligo. ... HSP70i accelerates depigmentation in a mouse model of autoimmune ...
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https://www.gponline.com/management-patients-vitiligo/dermatology/article/1373737
Psychological support is an important part of managing vitiligo. ... HSP70i accelerates depigmentation in a mouse model of autoimmune ...
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78
Mutant HSP70 Reverses Autoimmune Depigmentation in ...
https://www.lumi-derm.com/vitiligo/vitiligo-investigacion/mutant-hsp70-reverses-autoimmune-depigmentation-in-vitiligo-science-translational-medicine/
We previously showed that HSP70i induces an inflammatory dendritic cell (DC) phenotype and is necessary for depigmentation in vitiligo mouse ...
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https://www.lumi-derm.com/vitiligo/vitiligo-investigacion/mutant-hsp70-reverses-autoimmune-depigmentation-in-vitiligo-science-translational-medicine/
We previously showed that HSP70i induces an inflammatory dendritic cell (DC) phenotype and is necessary for depigmentation in vitiligo mouse ...
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79
Index - Dermatologic Clinics
https://www.derm.theclinics.com/article/S0733-8635(17)30020-7/pdf
and vitiligo in children, 231 ... and segmental vitiligo, 147, 148. Blister graft ... Household products and chemical-induced vitiligo, 155. HSP70i.
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https://www.derm.theclinics.com/article/S0733-8635(17)30020-7/pdf
and vitiligo in children, 231 ... and segmental vitiligo, 147, 148. Blister graft ... Household products and chemical-induced vitiligo, 155. HSP70i.
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80
Jussip Mukhatayev, Ph.D - Postdoctoral Research Fellow
https://www.linkedin.com/in/jussip-mukhatayev-ph-d-819a6b99
-Testing the efficacy of mutant HSP70i DNA vaccine for vitiligo in transgenic vitiligo-prone mouse model. This mutant HSP70i DNA vaccine has been tested on ...
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https://www.linkedin.com/in/jussip-mukhatayev-ph-d-819a6b99
-Testing the efficacy of mutant HSP70i DNA vaccine for vitiligo in transgenic vitiligo-prone mouse model. This mutant HSP70i DNA vaccine has been tested on ...
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81
Vitiligo Treatments: Is There a Cure? - GoodRx
https://www.goodrx.com/conditions/vitiligo/vitiligo-cure
There's no cure for vitiligo, but phototherapy, topical steroids, and even natural supplements can restore pigment.
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https://www.goodrx.com/conditions/vitiligo/vitiligo-cure
There's no cure for vitiligo, but phototherapy, topical steroids, and even natural supplements can restore pigment.
→ Check Latest Keyword Rankings ←
82
Vitiligo'ya protein tedavisi - Medimagazin
https://medimagazin.com.tr/hekim/vitiligoya-protein-tedavisi-49945
Caroline Le Pool ve ekibi, farelere amino asidi değiştirilen HSP70i proteinini enjekte etti. Mutasyona uğramış protein, hastalığın ortaya ...
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https://medimagazin.com.tr/hekim/vitiligoya-protein-tedavisi-49945
Caroline Le Pool ve ekibi, farelere amino asidi değiştirilen HSP70i proteinini enjekte etti. Mutasyona uğramış protein, hastalığın ortaya ...
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83
I. Caroline Le Poole PhD - 2021 Vitiligo Symposium
https://2021.vitiligosymposium.org/speaker/invited-speaker-5/
Indeed, short-term topical treatments did influence vitiligo development. ... on bringing modified HSP70i to patients as a potential treatment for vitiligo.
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https://2021.vitiligosymposium.org/speaker/invited-speaker-5/
Indeed, short-term topical treatments did influence vitiligo development. ... on bringing modified HSP70i to patients as a potential treatment for vitiligo.
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84
Ruxolitinib Cream Shows Improved Efficacy, Sustained Safety ...
https://www.ajmc.com/view/ruxolitinib-cream-shows-improved-efficacy-sustained-safety-in-vitiligo-after-extended-follow-up
Factors such as skin phenotype and disease duration have been indicated to potentially affect treatment efficacy in patients with vitiligo, and ...
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https://www.ajmc.com/view/ruxolitinib-cream-shows-improved-efficacy-sustained-safety-in-vitiligo-after-extended-follow-up
Factors such as skin phenotype and disease duration have been indicated to potentially affect treatment efficacy in patients with vitiligo, and ...
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85
Ruxolitinib Cream Gets Priority Review for Vitiligo Treatment
https://www.empr.com/home/news/drugs-in-the-pipeline/ruxolitinib-cream-gets-priority-review-for-vitiligo-treatment/
The FDA has accepted for Priority Review the sNDA for ruxolitinib cream to treat vitiligo.
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https://www.empr.com/home/news/drugs-in-the-pipeline/ruxolitinib-cream-gets-priority-review-for-vitiligo-treatment/
The FDA has accepted for Priority Review the sNDA for ruxolitinib cream to treat vitiligo.
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86
Vitiligo Clinical Research Trials - CenterWatch
https://www.centerwatch.com/clinical-trials/listings/condition/311/vitiligo/
Vitiligo Clinical Trials. A listing of Vitiligo medical research trials actively recruiting patient volunteers. Search for closest city to find more ...
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https://www.centerwatch.com/clinical-trials/listings/condition/311/vitiligo/
Vitiligo Clinical Trials. A listing of Vitiligo medical research trials actively recruiting patient volunteers. Search for closest city to find more ...
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87
The Promising Future of Vitiligo Treatment - HCPLive
https://www.hcplive.com/view/promising-future-vitiligo-treatment
› view › promising-future-viti...
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https://www.hcplive.com/view/promising-future-vitiligo-treatment
› view › promising-future-viti...
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88
Treatment For Vitiligo - Solarc Systems - USA & International
https://solarcsystems.com/treatment-for-vitiligo/
Vitiligo is a non-contagious autoimmune disease for which there is no known cure. Vitiligo causes localized skin depigmentation resulting in starkly white ...
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https://solarcsystems.com/treatment-for-vitiligo/
Vitiligo is a non-contagious autoimmune disease for which there is no known cure. Vitiligo causes localized skin depigmentation resulting in starkly white ...
→ Check Latest Keyword Rankings ←
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Vitiligo - Osmosis
https://www.osmosis.org/learn/vitiligo
Vitiligo, likely meaning blemish, is a non-contagious skin condition that is defined by patches of discoloration, or depigmentation.
→ Check Latest Keyword Rankings ←
https://www.osmosis.org/learn/vitiligo
Vitiligo, likely meaning blemish, is a non-contagious skin condition that is defined by patches of discoloration, or depigmentation.
→ Check Latest Keyword Rankings ←
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