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1 Causes of Restless Legs Syndrome (RLS)
https://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/restless-legs-syndrome/what-is-rls/causes.html
Marked improvement in RLS symptoms seen with drugs that stimulate the dopamine system and RLS-like symptoms produced with drug that block the dopamine system ...
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2 Restless Legs Syndrome Fact Sheet
https://www.ninds.nih.gov/restless-legs-syndrome-fact-sheet
Dopamine is needed to produce smooth, purposeful muscle activity and movement. Disruption of these pathways frequently results in involuntary movements.
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3 Restless legs syndrome - Illnesses & conditions - NHS inform
https://www.nhsinform.scot/illnesses-and-conditions/brain-nerves-and-spinal-cord/restless-legs-syndrome
If nerve cells become damaged, the amount of dopamine in the brain is reduced, which causes muscle spasms and involuntary movements. Dopamine levels naturally ...
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4 Restless legs syndrome - Symptoms and causes - Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/restless-legs-syndrome/symptoms-causes/syc-20377168
Often, there's no known cause for RLS . Researchers suspect the condition may be caused by an imbalance of the brain chemical dopamine, which ...
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5 Restless legs syndrome and related disorders - Mount Sinai
https://www.mountsinai.org/health-library/report/restless-legs-syndrome-and-related-disorders
Several studies support the theory that an imbalance in neurotransmitters (chemical messengers in the brain), notably dopamine, may play a part in RLS. Dopamine ...
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6 How credible are the proposed theories of Restless leg ...
https://www.entvoicesnoring.com/articles/2019/11/15/how-credible-are-the-proposed-theories-of-restless-leg-syndrome-pathophysiology-discuss-and-critically-evaluate-the-evidence
Although a baseline hyperdopaminergic state exists, there is a circadian pattern to dopaminergic activity in restless leg syndrome, with a ...
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7 The night time hustle: managing restless legs syndrome in ...
https://bpac.org.nz/bpj/2012/december/restlesslegs.aspx
Dopaminergic dysfunction and iron deficiency are both thought to have a role in restless legs syndrome. ... The syndrome is also strongly associated with ...
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8 Restless legs syndrome: An overview of pathophysiology ...
https://www.spandidos-publications.com/10.3892/etm.2021.11108
Administering a low dose of dopamine at night may be an apparent relief for the patient but it goes in a slippery-slope mechanism of increasing ...
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9 Restless Legs Syndrome
https://rarediseases.org/rare-diseases/restless-legs-syndrome/
The exact underlying cause of RLS symptoms is unknown. However, many researchers suggest that abnormalities in a certain neurotransmitter (dopamine) in the ...
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10 Restless legs syndrome - Pulmonology Advisor
https://www.pulmonologyadvisor.com/home/decision-support-in-medicine/pulmonary-medicine/restless-legs-syndrome/
RLS patients have brain iron deficiency despite a normal systemic iron status, which leads to dopamine dysfunction that produces the RLS ...
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11 Restless Legs Syndrome Treatments & Medications - WebMD
https://www.webmd.com/brain/restless-legs-syndrome/restless-leg-syndrome-treatment
Dopaminergic agents: These drugs, including Sinemet -- a combination of levodopa and carbidopa -- increase the level of dopamine in the brain and may improve ...
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12 Restless Legs Syndrome - AAFP
https://www.aafp.org/pubs/afp/issues/2008/0715/p235.html
If medications are needed, dopamine agonists are the primary medications for moderate to severe restless legs syndrome.
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13 Restless Legs Syndrome: From Pathophysiology to Clinical ...
https://www.frontiersin.org/articles/10.3389/fnagi.2017.00171/full
Iron deficiency in end-stage renal disease patients may lead to anemia and affect the dopamine metabolism, contributing to RLS (Nikic et al., ...
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14 Management of restless legs syndrome and periodic limb ...
https://www.uptodate.com/contents/management-of-restless-legs-syndrome-and-periodic-limb-movement-disorder-in-adults
Dopamine agonists — The non-ergot dopamine agonists, pramipexole, ropinirole, and rotigotine, are effective in the treatment of RLS at low doses ...
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15 The Management of Restless Legs Syndrome: An Updated ...
https://www.mayoclinicproceedings.org/article/S0025-6196(20)31489-0/fulltext
The choice of an alpha2-delta ligand as first-line therapy for chronic persistent RLS with dopamine agonists as a second-line option is ...
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16 Restless Leg Syndrome and Parkinson's Disease | APDA
https://www.apdaparkinson.org/article/restless-leg-syndrome/
Restless Legs Syndrome (RLS) is a neurologic and sleep-related condition characterized by an irresistible urge to move the legs. The symptoms respond to ...
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17 Possible Sites of Therapeutic Action in Restless Legs ...
https://www.karger.com/Article/Fulltext/328431
Dopaminergic drugs have shown efficacy as an RLS treatment in numerous large-scale clinical studies [17], and dopamine agonists improve RLS ...
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18 Long-term Treatment of Restless Legs Syndrome With ...
https://jamanetwork.com/journals/jamaneurology/fullarticle/786586
Conclusions Dopamine agonists continued to effectively treat RLS without long-term adverse events but often required adjustments across time. The higher rate of ...
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19 Restless Legs Syndrome - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/nursing-and-health-professions/restless-legs-syndrome
RLS has been linked to deficient iron stores and dopaminergic neurotransmission in the brain and is more common in patients with parkinsonism, multiple ...
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20 Restless Legs Syndrome | Diagnosis & Treatment - UCHealth
https://www.uchealth.org/diseases-conditions/restless-legs-syndrome/
Iron deficiency. Low levels of iron in the blood or brain can lead to lower dopamine levels, which can cause RLS. People with heavy menstrual periods or who ...
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21 2-Minute Neuroscience: Restless Legs Syndrome - YouTube
https://www.youtube.com/watch?v=D6WmNTQTAfc
Neuroscientifically Challenged
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22 Dopamine Transporter is Decreased in the Striatum of ...
https://academic.oup.com/sleep/article/34/3/341/2433831
Prior studies, all using SPECT techniques, failed to find any differences for dopamine transporter (DAT) in restless legs syndrome (RLS) subjects.
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23 Imbalance between thyroid hormones and the dopaminergic ...
https://www.scielo.br/j/clin/a/T8HQX8qrm4t7RCwc6tB36kP/?lang=en
Dopamine (DA), when diminished, plays an important role in the pathophysiology of Restless Legs Syndrome (RLS) when decreased DA levels are a primary condition, ...
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24 The 11 Best Treatments for Restless Legs Syndrome
https://www.healthline.com/health/restless-leg-syndrome/treatments
Because of the effects RLS can have on your life, treatment is important. Methods of treatment are varied, as the root cause of RLS isn't truly known. For ...
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25 Restless Legs Syndrome (RLS): Causes, Symptoms, Diagnosis
https://my.clevelandclinic.org/health/diseases/9497-restless-legs-syndrome
Dopamine agonists control the urge to move, sensory symptoms in the legs, and reduce involuntary leg jerks in sleep. · Anti-seizure medications ...
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26 The Adenosine Hypothesis of Restless Legs Syndrome
https://www.liebertpub.com/doi/10.1089/caff.2019.0001
Counterintuitively, in the frame of a presynaptic hyperdopaminergic state, dopamine agonists, such as pramipexole and ropinirole, are clinically ...
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27 Restless Legs Syndrome and Mood Disorders - Psychiatrist.com
https://www.psychiatrist.com/jcp/bipolar/mood-disorders/mood-disorders-restless-legs-syndrome-willis-ekbom/
As previously mentioned, dopaminergic treatment may have beneficial effects on comorbid mood disorders in addition to improving symptoms of RLS.
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28 New Research Identifies Adenosine Role in RLS
http://rlsfoundation.blogspot.com/2018/07/new-research-identifies-adenosine-role.html
It has long been believed that RLS is related to a malfunction in the way the brain uses dopamine. Dopamine is a neurotransmitter (a brain ...
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29 Restless legs syndrome - RCP Journals
https://www.rcpjournals.org/content/clinmedicine/16/4/379
In general, the dosage should be kept as low as possible and should be administered as a single evening dose. If the patient shows intolerance to one dopamine ...
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30 8 Restless Legs Syndrome Triggers | Everyday Health
https://www.everydayhealth.com/sleep-disorders/restless-leg-syndrome/8-restless-legs-syndrome-triggers/
It transmits brain messages, helps control body movements and alters central nervous system function.“Dopamine levels are lower at night, which ...
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31 Restless Leg Syndrome - Symptoms and Causes
https://www.pennmedicine.org/for-patients-and-visitors/patient-information/conditions-treated-a-to-z/restless-leg-syndrome
No one knows exactly what causes RLS. It may be due to a problem with the way brain cells use dopamine. Dopamine is a brain chemical that helps with muscle ...
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32 Restless Leg Syndrome | Michigan Medicine
https://www.uofmhealth.org/conditions-treatments/brain-neurological-conditions/restless-leg-syndrome
All medications have potential side effects and should be used only under the supervision of a physician trained in the treatment of this disorder. Some ...
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33 An Updated Algorithm - Restless Legs Syndrome Foundation
https://www.rls.org/21Algorithm
for treatment of chronic persistent RLS, with dopamine agonists second-line drugs. d Low-dose opioid therapy is indicated for the management of.
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34 The Link Between Iron Deficiency and Restless Leg Syndrome
https://veincenterelpaso.com/post/the-link-between-iron-deficiency-and-restless-leg-syndrome
Research shows that RLS symptoms are directly related to how well your brain produces and uses dopamine. When iron levels are low, the brain can ...
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35 Restless Legs Syndrome - Baylor College of Medicine
https://www.bcm.edu/healthcare/specialties/neurology/parkinsons-disease-and-movement-disorders/restless-legs-syndrome
A series of other dopamine drugs called agonists (dopamine mimickers) have since been shown to markedly improve RLS symptoms, often more than Sinemet. These ...
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36 Surprising Cause of the Restless Legs Syndrome (RLS)
https://www.healthaid.co.uk/blogs/news/surprising-cause-of-the-restless-legs-syndrome-rls
Deficiency of dopamine is regarded as the most frequent cause of RLS. There is a clear link between RLS and low levels of dopamine in the ...
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37 Dopamine Agonists to Treat Restless Legs Syndrome
https://restlesslegssyndrome.sleep-disorders.net/dopamine-agonists
Dopamine agonists are a group of drugs that imitate the brain chemical dopamine. This makes the brain think it is getting enough dopamine. Low ...
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38 Restless legs syndrome: MedlinePlus Medical Encyclopedia
https://medlineplus.gov/ency/article/000807.htm
No one knows exactly what causes RLS. It may be due to a problem with the way brain cells use dopamine. Dopamine is a brain chemical that helps ...
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39 Remedies for Restless Legs Syndrome - Dr Wholeness
https://drwholeness.com/blog/remedies-for-restless-leg-syndrome/
One study actually demonstrated a 4x difference between daytime dopamine and night time dopamine levels in people with restless leg syndrome. In ...
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40 Restless Legs Syndrome: A Disorder of Dopamine ...
https://www.reliasmedia.com/articles/122157-restless-legs-syndrome-a-disorder-of-dopamine-neurotransmission
The present study re-investigates the controversial question of whether there exist dopamine neurotransmission abnormalities in RLS and, in contrast to previous ...
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41 Restless Legs Syndrome across the Lifespan - MDPI
https://www.mdpi.com/1660-4601/17/10/3658/htm
The dopamine pathophysiology of RLS finds its fundamentals in the discovery of the dramatic response to dopaminergic agents (first levodopa, in the early 1980s, ...
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42 Neurochemistry of Idiopathic Restless Legs Syndrome
https://touchneurology.com/movement-disorders/journal-articles/neurochemistry-of-idiopathic-restless-legs-syndrome/
The excellent therapeutic response of RLS to dopaminergic drugs, together with some neuropathological, neuroimaging, biochemical and ...
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43 Restless legs syndrome: Causes, treatments, and home ...
https://www.medicalnewstoday.com/articles/7882
Restless legs syndrome (RLS) may happen because of mental or physical problems, or it may be an adverse effect of some medications. It is also known as Willis- ...
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44 Restless legs syndrome - Wikipedia
https://en.wikipedia.org/wiki/Restless_legs_syndrome
Restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED), is generally a long-term disorder that causes a strong urge to move one's legs.
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45 Effect of exercise training and dopamine agonists in patients ...
https://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-14-194
A 6-month exercise training regime was as effective as a 6-month low dosage dopamine agonist treatment in reducing restless legs syndrome ...
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46 Restless legs syndrome - Ekbom - 2009 - Wiley Online Library
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2796.2009.02159.x
Dopamine. According to a commonly held view RLS may be due to dysfunction of dopamine cells in the nigro-striatal areas of the brain.
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47 Restless legs syndrome - Australian Prescriber
https://www.nps.org.au/australian-prescriber/articles/restless-legs-syndrome-1
Restless legs syndrome is a common but under-recognised disorder. For patients with mild symptoms, no drug treatment may be necessary. For patients with severe ...
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48 Restless Legs Syndrome: A Common, Underdiagnosed ...
https://www.uspharmacist.com/article/restless-legs-syndrome-a-common-underdiagnosed-disorder
The cause of RLS remains unclear, but research suggests that impaired dopamine activity in the brain due to iron insufficiency may induce RLS in ...
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49 Neuroscience for Kids - Restless Legs Syndrome (RLS)
https://faculty.washington.edu/chudler/rls.html
Dopamine deficiency: medications that increase levels of the neurotransmitter dopamine may relieve RLS symptoms. Diagnosis of RLS. There is no blood test or ...
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50 What Causes Restless Legs Syndrome? - Sleep Foundation
https://www.sleepfoundation.org/restless-legs-syndrome/what-causes-restless-legs-syndrome
Although studies continue to suggest that both low iron levels in the brain and problems with dopamine transmission play roles in RLS, ...
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51 Differential Diagnosis and Treatment of Restless Legs ...
https://www.cureus.com/articles/13971-differential-diagnosis-and-treatment-of-restless-legs-syndrome-a-literature-review
Restless legs syndrome (RLS) is a chronic neurological disorder ... severe RLS symptoms that may require a low-dose dopamine agonist to ...
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52 Restless Legs Syndrome: Symptoms, Causes, and Treatments
https://sleepopolis.com/education/restless-leg-syndrome/
Dopamine dysfunction. There is strong evidence to suggest that RLS may result from an imbalance of dopamine, a brain chemical involved in ...
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53 Nocturnal Restless Arms and Face Improved by Dopamine ...
https://www.e-jsm.org/journal/view.php?number=224
Restless legs syndrome (RLS) is a sensorimotor disease characterized by abnormal sensation in legs and motor restlessness that often has a ...
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54 Dopamine and Iron in Restless Legs Syndrome - Grantome
https://grantome.com/grant/NIH/R01-NS042857-01A1
Like Parkinson's disease, restless legs syndrome is exquisitely sensitive to dopamine agents and aggravated or precipitated by dopamine antagonists.
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55 Restless Legs Syndrome - Brain Disorders A-Z
https://brainfoundation.org.au/disorders/restless-legs-syndrome/
The major class of medication that helps in restless legs syndrome are those that increase dopamine transmission in the central nervous system. These include ...
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56 Restless Legs Syndrome (RLS) - HelpGuide.org
https://www.helpguide.org/articles/sleep/restless-leg-syndrome-rls.htm
Experts believe that low levels of iron in the brain may be responsible for RLS. An imbalance of dopamine is also believed to contribute.
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57 Restless legs syndrome
https://aasm.org/resources/factsheets/rls.pdf
Restless legs syndrome (RLS) is a sleep-related movement disorder that ... Iron deficiency and all conditions that produce it increase the risk of RLS, ...
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58 Restless Legs Syndrome: How to Fight a Condition That's ...
https://www.muhealth.org/our-stories/restless-legs-syndrome-how-fight-condition-thats-stealing-your-sleep
If iron deficiency is not the cause, there are treatments to lessen the symptoms of restless legs syndrome. Dopamine agonist drugs such as ropinirole and ...
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59 Restless Legs Syndrome: Current Concepts about Disease ...
https://tremorjournal.org/article/10.5334/tohm.322/
Pathologically, the most consistent finding is striatal iron deficiency in RLS patients. A host of other biological systems are also altered in ...
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60 How to Identify and Treat Restless Leg Syndrome - GoodRx
https://www.goodrx.com/conditions/restless-leg-syndrome/restless-legs-syndrome
The exact cause of RLS is unknown. It tends to run in families, suggesting it could be inherited, but it has also been linked to iron deficiency ...
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61 Restless Legs Syndrome - Medscape Reference
https://emedicine.medscape.com/article/1188327-overview
Results of single-photon emission computed tomography (SPECT) have suggested a deficiency of dopamine D2 receptors. Iron homeostasis ...
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62 Restless Legs Syndrome: clinical features, diagnosis and a ...
https://pn.bmj.com/content/practneurol/17/6/444.full.pdf
RLS symptoms. Dopamine agonists can still be used as first-line therapy, but the dose should be kept as low as possible.
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63 Signs of restless legs syndrome - Ada Health
https://ada.com/conditions/restless-legs-syndrome/
Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a chronic condition that causes strong, unpleasant feelings in the legs, ...
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64 Restless legs syndrome - RACGP
https://www.racgp.org.au/getattachment/87576673-c695-48f6-a806-065da7e5fcc7/Restless-legs-syndrome.aspx
to pharmacotherapy (eg. dopamine agonists, levodopa, opioids,. Background. Restless legs syndrome (RLS) is a common, but frequently.
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65 The ABCs of RLS: Restless Legs Syndrome - tl;dr pharmacy
https://www.tldrpharmacy.com/content/the-abcs-of-rls-restless-legs-syndrome
If symptoms are reduced by at least 50%, then the patient is determined to have RLS. Due to this responsiveness, the dopaminergic pathway ...
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66 Restless Legs Syndrome: Contemporary Diagnosis and ...
https://link.springer.com/article/10.1007/s13311-021-01019-4
Since dopamine agonists relieve RLS symptoms, it may be reasonably anticipated that brain dopamine levels should be low in RLS patients. However ...
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67 Restless Legs Syndrome in Children - Stanford Health Care
https://stanfordhealthcare.org/medical-conditions/sleep/pediatric-sleep-disorders/types/restless-legs-syndrome.html
The cause of RLS also likely involved abnormal Dopamine. Dopamine is an important neurochemical in the brain that is involved in sleep, movements (for example ...
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68 Restless Leg Syndrome - Life Extension
https://www.lifeextension.com/protocols/neurological/restless-leg-syndrome
RLS can be classified as primary or secondary; the exact cause of primary RLS is not known, although altered dopamine signaling is thought to play a part, while ...
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69 Restless Legs Syndrome | FX Medicine
https://www.fxmedicine.com.au/blog-post/restless-legs-syndrome
Treatment strategies for RLS include correcting iron deficiency, supporting dopamine synthesis and improving relaxation and quality of sleep ...
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70 Controversies and Challenges in Defining the Etiology and ...
https://www.amjmed.com/article/S0002-9343(06)01294-0/abstract
Restless legs syndrome (RLS) can occur as a primary disorder, ... RLS is associated with decreased dopaminergic neurotransmission includes the observation ...
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71 Restless Legs Syndrome & Periodic Limb Movements During ...
https://www.utmedicalcenter.org/medical-care/medical-services/procedures-treatments/restless-legs-syndrome-periodic-limb-movements-during-sleep/
The cause of RLS may also involve abnormal dopamine metabolism. Dopamine is an important neurochemical in the brain that is involved in sleep and movements (for ...
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72 Understanding Restless Legs Syndrome | Franciscan Health
https://www.franciscanhealth.org/community/blog/restless-leg-syndrome
“There is no known, definitive cause for restless legs syndrome, though researchers believe it may be linked to dopamine imbalances in the brain ...
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73 Restless legs syndrome - Sparrow Health System
https://www.sparrow.org/departments-conditions/conditions/restless-legs-syndrome
Sometimes dopamine medications that have worked for a while to relieve your RLS become ineffective, or you notice your symptoms returning ...
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74 Restless Legs Got You Up All Night? - Align Healing Center
https://www.alignhealingcenter.com/blog/restless-legs-got-you-up-all-night
RLS has been linked to low levels of dopamine. The neurotransmitter Dopamine is an important messenger in the brain helping to regulate much of our body's ...
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75 Symptom Persistence after Iron Normalization in Women with ...
https://www.psychiatryinvestigation.org/m/journal/view.php?number=847
Among possible pathophysiology of primary RLS, brain iron deficiency and central dopamine dysfunction have been suggested. Serum ferritin level ...
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76 The Treatment and Management of Restless Legs Syndrome
https://www.medscape.org/viewarticle/522010_6
Piribedil, a nonergot D2 and D3 dopamine agonist, is effective even at a low dose of 25 mg/day. ... Cabergoline, a long-acting ergot dopamine agonist, can provide ...
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77 Do I Have Restless Legs Syndrome?
https://www.thensf.org/do-i-have-restless-legs-syndrome/
This part of the brain relies on a chemical called dopamine to signal to the muscles that it's time to act. In normal circumstances, dopamine ...
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78 Restless Legs Syndrome - 4 Less-Known Causes
https://chriskresser.com/4-little-known-causes-of-restless-legs-syndrome/
3. Vitamin D Deficiency ... As I mentioned in the introduction, one of the most-researched theories about the cause of restless legs syndrome is impaired dopamine ...
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79 Challenges in the Treatment of Restless Legs Syndrome
https://journals.sagepub.com/doi/10.1177/21501327211019590
The dopaminergic profile in RLS patients includes abnormally high cerebrospinal fluid levels of the dopamine metabolite 3-OMD, interpreted to indicate increased ...
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80 Comparison of Pregabalin with Pramipexole for Restless Legs ...
https://www.nejm.org/doi/full/10.1056/nejmoa1303646
Dopaminergic medications relieve symptoms of the restless legs syndrome (RLS) but have the potential to cause iatrogenic worsening ...
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81 Restless Legs Syndrome, the Pitfall: Hardly Diagnosed and ...
https://austinpublishinggroup.com/clinical-neurology/fulltext/ajcn-v4-id1118.php
Relations to the lower cerebral ferric and Dopamine levels are probably reported as the cause for Restlessness like, although genetic biomarkers have been ...
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82 Restless Legs Syndrome - Hormones Matter
http://www.hormonesmatter.com/restless-legs-syndrome/
Levodopa is converted into dopamine in the body, and therefore it was thought that RLS resulted from a deficiency of dopamine, and thus was ...
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83 Restless legs syndrome: Treatment overview - Allen Press
https://meridian.allenpress.com/mhc/article/2/2/37/36883/Restless-legs-syndrome-Treatment-overview
RLS has been linked to iron deficiency in the body, particularly within dopamine containing neurons. ... Magnetic resonance imaging, studies of ...
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84 RESTLESS LEGS SYNDROME AND PARKINSON'S
https://davisphinneyfoundation.org/restless-legs-syndrome-parkinsons/
As we stated above, many people with RLS have difficulty falling asleep due to their legs' tingling sensations and restlessness. In these cases, ...
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85 Restless legs syndrome, insomnia and brain chemistry
https://www.sciencedaily.com/releases/2013/05/130507134600.htm
Dopamine-related drugs currently used in RLS do work, but many patients eventually lose the drug benefit and require ever higher doses. When the ...
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86 Treating Severe Refractory and Augmented Restless Legs ...
https://journal.chestnet.org/article/S0012-3692(22)01008-X/fulltext
Restless legs syndrome (RLS) is a sensory-motor neurologic ... Mild dopaminergic augmentation of RLS symptoms in patients on low doses of ...
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87 Restless legs syndrome in Parkinson disease - Nature
https://www.nature.com/articles/s41598-017-10593-7
PD-RLS was common and severer in motor and some non-motor symptoms. Iron deficiency induced by its metabolism dysfunctions in peripheral and ...
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88 Glutamate, Hyperarousal and Restless Legs Syndrome
https://clinicaltrials.gov/ct2/show/NCT01675323
It is well known that dopamine deficiency leads to the manifestations of restless legs syndrome (RLS). Studies have shown dopamine agonists ...
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89 Restless Leg Syndrome: Essential Facts for Patients
https://www.movementdisorders.org/MDS/Resources/Patient-Education/Restless-Leg-Syndrome.htm
For example, if a patient has low iron storage levels, iron replacement may help. The following medications may also help the symptoms of RLS: 'Dopamine' ...
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90 What are the causes of Restless Legs Syndrome? - DR.VEGAN
https://drvegan.com/blogs/articles/restless-legs-syndrome-causes-and-how-to-manage-it
Dopamine is a chemical involved in controlling muscle movement and may be responsible for the involuntary leg movements associated with RLS.
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91 Restless leg syndrome - NHS 111 Wales
https://111.wales.nhs.uk/encyclopaedia/r/article/restlesslegsyndrome/
Dopamine levels naturally fall towards the end of the day, which may explain why the symptoms of restless legs syndrome are often worse in the ...
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92 Dopamine agonists for restless legs syndrome - Cochrane
https://www.cochrane.org/CD006009/MOVEMENT_dopamine-agonists-for-restless-legs-syndrome
Dopamine agonists lead to a larger improvement on the International RLS Severity Rating Scale (IRLS) compared to placebo. Clinicians rated RLS ...
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93 Periodic Limb Movement Disorder (PLMD) and Restless Legs ...
https://www.merckmanuals.com/professional/neurologic-disorders/sleep-and-wakefulness-disorders/periodic-limb-movement-disorder-plmd-and-restless-legs-syndrome-rls
Periodic limb movement disorder is characterized by repetitive (usually every 20 to 40 seconds) twitching or kicking of the lower or upper extremities during ...
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