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1 Specific Targeting of Plasma Kallikrein for ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/34838707/
Hereditary angioedema nl-C1INH is caused by either a known or unknown genetic mutation. The underlying mechanism of HAE-nl-C1INH is less well understood but is ...
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2 What Causes Hereditary Angioedema (HAE)?
https://www.discoverhae.com/hereditary-angioedema-causes
Increased kallikrein activity leads to excess bradykinin production, which causes the swelling of an HAE attack. Decreased C1 esterase inhibitor proteins are ...
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3 A new oral kallikrein inhibitor for long‐term prophylaxis of ...
https://onlinelibrary.wiley.com/doi/10.1111/all.14798
Hereditary angioedema (HAE) is a rare inherited chronic disease characterized by unpredictable recurrent attacks of cutaneous and submucosal ...
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4 Oral plasma kallikrein inhibitor BCX7353 for treatment of ...
https://www.futuremedicine.com/doi/10.2217/imt-2019-0128
Hereditary angioedema (HAE) is rare disorder caused by a SERPING1 gene mutation that triggers severe swelling of the skin and upper airway.
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5 Specific Targeting of Plasma Kallikrein for Treatment of ...
https://www.jaci-inpractice.org/article/S2213-2198(21)01289-7/fulltext
Hereditary angioedema (HAE) is a rare, chronic, genetic disease that ... Plasma kallikrein inhibitors have been developed to inhibit the ...
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6 Specific Targeting of Plasma Kallikrein for Treatment of ...
https://www.sciencedirect.com/science/article/pii/S2213219821012897
Hereditary angioedema (HAE) is a rare, chronic, genetic disease that presents with nonpruritic angioedema of the face, extremities, airway (can be ...
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7 Hereditary angioedema (HAE) prophylaxis with plasma ...
https://www.jacionline.org/article/S0091-6749(19)32333-4/abstract
... Plasma Kallikrein Inhibitor, for the Treatment of Hereditary Angioedema (HAE) ... BCX7353 is a small-molecule human plasma kallikrein inhibitor that is ...
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8 Berotralstat (BCX7353): Structure-Guided Design of a Potent ...
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00511
Hereditary angioedema (HAE) is a rare and potentially ... Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE).
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9 Genetic Variation of Kallikrein-Kinin System and Related ...
https://www.frontiersin.org/articles/10.3389/fmed.2019.00028/full
Hereditary angioedema (HAE) is an autosomal dominant disease caused by C1-INH deficiency due to mutations in SERPING1 (C1-INH-HAE) in most ...
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10 Hereditary Angioedema: A Broad Review for Clinicians
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/649449
Hereditary angioedema (HAE) is an autosomal dominant disease that afflicts ... XIIf, and XIa; and direct inhibition of activated kallikrein.
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11 Full article: Hereditary angioedema: examining the landscape ...
https://www.tandfonline.com/doi/full/10.1080/14728222.2019.1608949
The time since hereditary angioedema (HAE) – a rare or orphan disease – was ... Plasma kallikrein cleaves high-molecular-weight kininogen ...
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12 Medline ® Abstract for Reference 73 of 'Hereditary angioedema
https://www.uptodate.com/contents/hereditary-angioedema-acute-treatment-of-angioedema-attacks/abstract/73
TI: Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the prevention of blood loss in on-pump cardiothoracic ...
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13 Hereditary angioedema | UF Health, University of Florida Health
https://ufhealth.org/hereditary-angioedema
Quincke disease; HAE - Hereditary angioedema; Kallikrein inhibitor - HAE; Bradykinin receptor antagonist - HAE; C1-inhibitors - HAE; ...
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14 ACAAI 2021: Investigational Plasma Kallikrein Inhibitor STAR ...
https://www.practiceupdate.com/content/acaai-2021-investigational-plasma-kallikrein-inhibitor-star-215-shows-promise-in-hereditary-angioedema/127036
News · November 16, 2021. ACAAI 2021: Investigational Plasma Kallikrein Inhibitor STAR-215 Shows Promise in Hereditary Angioedema.
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15 Recognition and Management of Hereditary Angioedema
https://link.springer.com/article/10.1007/s13555-021-00593-x
Pathway-specific HAE treatments include C1INH replacement, kallikrein inhibitors, and bradykinin receptor antagonists. Treatment options for ...
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16 PRO7 A NETWORK META-ANALYSIS COMPARING C1 AND ...
https://www.valueinhealthjournal.com/article/S1098-3015(19)31833-9/fulltext
... KALLIKREIN INHIBITORS APPROVED FOR PROPHYLAXIS OF HEREDITARY ANGIOEDEMA IN ... Hereditary angioedema (HAE) is a rare autosomal dominant genetic disorder ...
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17 A review of oral kallikrein inhibitor berotralstat for hereditary ...
https://pennstate.pure.elsevier.com/en/publications/a-review-of-oral-kallikrein-inhibitor-berotralstat-for-hereditary
Preclinical and phase I studies showed promising efficacy and safety, and several multicenter international Angioedema Prophylaxis (APeX) phase ...
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18 Hereditary Angioedema Medication - Medscape Reference
https://emedicine.medscape.com/article/135604-medication
In August 2018, the FDA approved lanadelumab, a monoclonal antibody that targets kallikrein, for prophylaxis of HAE. Approval was based on the ...
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19 Inhibiting Plasma Kallikrein for Hereditary ... - YouTube
https://www.youtube.com/watch?v=JtVeZk1hiUM
Feb 23, 2017
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20 STAR-0215, a Kallikrein Inhibitor for HAE, Has Lasting Effect ...
https://angioedemanews.com/news/star-0215-kallikrein-inhibitor-hae-has-lasting-effect-monkeys/
Astria Therapeutics' STAR-0215 is designed to inhibit the activity of kallikrein, which is abnormally active in hereditary angioedema.
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21 CRISPR treatment slows swelling in hereditary angioedema ...
https://www.sciencedaily.com/releases/2022/11/221110101802.htm
Prophylactic treatments targeting kallikrein significantly reduced frequency of attacks. Date: November 10, 2022; Source: American College of Allergy, ...
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22 A novel murine in vivo model for acute hereditary angioedema ...
https://www.nature.com/articles/s41598-021-95125-0.pdf?proof=t
Hereditary Angioedema (HAE) is a rare genetic disease generally caused by ... The plasma kallikrein inhibitor ecallantide inhibits SiNP‑induced blood ...
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23 Publications | KalVista Pharmaceuticals, Inc
https://www.kalvista.com/healthcare-providers/publications
Impact of Hereditary Angioedema (HAE) Attacks on Quality of Life and Activities ... Efficacy and Safety of the Oral Plasma Kallikrein Inhibitor Sebetralstat ...
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24 5.01.587 Hereditary Angioedema - Premera Blue Cross
https://www.premera.com/medicalpolicies/5.01.587.pdf
Inhibiting plasma kallikrein for hereditary angioedema prophylaxis. N Engl J Med. 2017;376(8):717-728. 3. Johnston DT, Anderson JT, Schranz ...
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25 Oral Plasma Kallikrein Inhibitor Significantly Reduces Attacks ...
https://www.hcplive.com/view/oral-plasma-kallikrein-inhibitor-significantly-reduces-attacks-of-hereditary-angioedema
Hereditary angioedema (HAE) can be treated with a new drug called BCX7353, according to a paper published in The New England Journal of ...
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26 Hereditary Angioedema (HAE) - Therapies
https://www.rarediseaseadvisor.com/therapies/hereditary-angioedema-experimental-therapies/
ATN-249, developed by Attune Pharmaceuticals, is a potent, selective, and orally-administered plasma kallikrein inhibitor under investigation ...
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27 Hereditary angioedema | British Society for Immunology
https://www.immunology.org/public-information/bitesized-immunology/immune-dysfunction/hereditary-angioedema
Potential disease modifying genes or pathways have been suggested to include BK2R, kallikrein, factor XII, ACE and oestrogen. The role of bradykinin in other ...
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28 What is Hereditary Angioedema? - GoodRx
https://www.goodrx.com/hereditary-angioedema
Treatment for hereditary angiodema includes medication. C1 inhibitors, plasma kallikrein inhibitors, and bradykinin receptor antagonists are commonly used drug ...
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29 Bradykinin's Role In HAE Attacks - Firazyr
https://www.firazyr.com/hcp/what-is-firazyr/bradykinin
... of hereditary angioedema (HAE) in adults 18 years of age and older. ... in plasma kallikrein activity, triggering an overproduction of bradykinin.
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30 Management of acute attacks of hereditary angioedema
https://www.dovepress.com/management-of-acute-attacks-of-hereditary-angioedema-role-of-ecallanti-peer-reviewed-fulltext-article-JBM
Keywords: idiopathic angioedema, ACE-Inhibitor induced angioedema, nonhistaminergic angioedema, bradykinin, acquired angioedema, Kallikrein, ...
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31 Inhibiting Plasma Kallikrein for Hereditary Angioedema ...
https://www.medscape.org/medline/abstract/28225674
Lanadelumab (DX-2930) is a new kallikrein inhibitor with the potential for prophylactic treatment of hereditary angioedema with C1 inhibitor deficiency.
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32 Hereditary Angioedema (HAE), Treatment and Prophylaxis
https://www.uhcprovider.com/content/dam/provider/docs/public/policies/comm-medical-drug/hereditary-angioedema-treatment-prophylaxis.pdf
Suppression of contact system activation by C1 inhibitor through the inactivation of plasma kallikrein and factor XIIa is thought to modulate ...
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33 How Do Kallikrein Inhibitors Work? - Uses, Side Effects, Drug ...
https://www.rxlist.com/how_do_kallikrein_inhibitors_work/drug-class.htm
Kallikrein inhibitors are a class of drugs used to prevent and treat attacks due to an inherited immune disease “hereditary angioedema” ...
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34 an inhibitory regulatory role for the factor XII heavy chain | Blood
https://ashpublications.org/blood/article-abstract/133/10/1152/272753/A-mechanism-for-hereditary-angioedema-with-normal
Patients with hereditary angioedema (HAE) experience episodes of soft tissue swelling as a consequence of unregulated kallikrein activity or increased ...
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35 Hereditary Angioedema - Medical Clinical Policy Bulletins
https://www.aetna.com/cpb/medical/data/700_799/0782.html
Aetna considers plasma kallikrein inhibitor, lanadelumab-flyo (Takhzyro) medically necessary for prevention of hereditary angioedema (HAE) attacks when the ...
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36 Use of recombinant plasma kallikrein inhibitor in hereditary ...
https://www.joms.org/article/S0278-2391(04)01173-5/fulltext
Hereditary angioedema (HAE) is a disease characterized by a rapid onset of nonpitting edema affecting the face, extremities, and mucosal surfaces of the ...
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37 Hereditary Angioedema (HAE) Therapy - Cigna
https://static.cigna.com/assets/chcp/pdf/coveragePolicies/pharmacy/ph_1019_coveragepositioncriteria_hereditary_angioedema.pdf
indicated for routine prophylaxis to prevent Hereditary Angioedema (HAE) attacks in adolescent and adult patients. Kalbitor. Kalbitor is a plasma kallikrein ...
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38 Mechanism of Action | ORLADEYO® (berotralstat) HCP
https://orladeyohcp.com/clinical-info/mechanism-of-action/
Targeted inhibition of plasma kallikrein has long been known to help prevent hereditary angioedema (HAE) attacks2. HAE is primarily caused by uncontrolled ...
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39 Ecallantide for the Treatment of Hereditary Angiodema in Adults
https://journals.sagepub.com/doi/pdf/10.4137/CMC.S4434
Kallikrein inhibitor. 1–4 h. SC. FDA approved for the treatment of acute HAE attacks. Abbreviations: HAE, hereditary angioedema; IV, intravenous; SC, ...
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40 Hereditary Angioedema and Gastrointestinal Complications
https://www.hindawi.com/journals/crii/2015/925861/
Hereditary Angioedema (HAE) is a rare autosomal dominant (AD) disease ... The angioedema is caused by the activation of the kallikrein-kinin system that ...
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41 The hereditary angioedema syndromes - JCI
https://www.jci.org/articles/view/125378
Hereditary angioedema (HAE) is a rare genetic disorder primarily caused by ... factor XIIa (αFXIIa), plasma kallikrein (PKa), C1 esterase, ...
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42 Hereditary Angioedema Agents | AmeriHealth
https://www.amerihealth.com/pdfs/providers/pharmacy_information/pharmacy_policies/hereditary-angioedema-agents.pdf
Orladeyo™ (berotralstat) is a plasma kallikrein inhibitor indicated for prophylaxis to prevent attacks of hereditary angioedema (HAE) in adults and ...
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43 Prophylaxis with anti-activated factor XII for hereditary ...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02436-3/fulltext
Hereditary angioedema is a rare autosomal dominant genetic disorder characterised by ... consisting of factor XII (FXII), plasma kallikrein, ...
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44 Hereditary angioedema | DermNet
https://dermnetnz.org/topics/hereditary-angioedema
C1-INH also regulates the contact (kallikrein-kinin) system, which is responsible for inflammation and blood coagulation. It involves factor XII, factor XIIa, ...
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45 Study of BCX7353 as a Treatment for Attacks of Hereditary ...
https://clinicaltrials.gov/ct2/show/NCT03240133
Time to use of conventional attack treatment [ Time Frame: 12 hours ]. Secondary Outcome Measures : Proportion of hereditary angioedema (HAE) attacks that (1) ...
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46 Hereditary angioedema: an update on causes, manifestations ...
https://www.magonlinelibrary.com/doi/10.12968/hmed.2019.80.7.391
Hereditary angioedema is a rare genetic disorder caused by deficiency of ... Activated FXII (FXIIa) converts prekallikrein into kallikrein, ...
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47 Hereditary Angioedema Symptoms, Doctors, Treatments ...
https://www.medifind.com/conditions/hereditary-angioedema/2425
Quincke disease; HAE - Hereditary angioedema; Kallikrein inhibitor - HAE; Bradykinin receptor antagonist - HAE; C1-inhibitors - HAE; Hives - HAE.
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48 Advances in the Pharmacotherapy of Hereditary Angioedema
https://www.uspharmacist.com/article/advances-in-the-pharmacotherapy-of-hereditary-angioedema
Factor XII activates kallikrein, leading to a similar end result of types I and II HAE bradykinin overproduction.13. General Principles of ...
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49 Kallikrein Inhibitor Lanadelumab Prevents Hereditary ...
https://rheumnow.com/content/kallikrein-inhibitor-lanadelumab-prevents-hereditary-angioedema-attacks
Hereditary angioedema is a rare autosomal dominant disorder due to C1 inhibitor deficiency (type I) or dysfunction (type II) that leads to ...
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50 FDA Fast-Tracks Plasma Kallikrein Inhibitor for Angioedema ...
https://www.empr.com/home/news/drugs-in-the-pipeline/fda-fast-tracks-plasma-kallikrein-inhibitor-for-angioedema-attacks-in-hae/
BCX7353 (BioCryst), a novel treatment being developed to treat and prevent angioedema attacks in patients with hereditary angioedema (HAE), ...
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51 Antisense Drug Slashed Hereditary Angioedema Attacks in ...
https://www.medpagetoday.com/allergyimmunology/allergy/97702
Patients with hereditary angioedema who were treated with an antisense ... the mRNA of plasma prekallikrein, a precursor to kallikrein.
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52 Astria Therapeutics Announces Initiation of Phase 1a Trial of ...
https://www.yahoo.com/now/astria-therapeutics-announces-initiation-phase-120000093.html
STAR-0215 is a monoclonal antibody inhibitor of plasma kallikrein designed ... of Plasma Kallikrein for Treatment of Hereditary Angioedema.
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53 CRISPR Treatment Slows Swelling in Hereditary Angioedema ...
https://acaai.org/news/crispr-treatment-slows-swelling-in-hereditary-angioedema-patients/
Hereditary angioedema is a rare, genetic disorder characterized by severe, ... Prophylactic treatments targeting kallikrein significantly ...
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54 Ongoing Contact Activation in Patients with Hereditary ... - PLOS
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074043
Hereditary angioedema (HAE) is predominantly caused by a deficiency in C1 ... Hence, in vivo, activation of the kallikrein system without ...
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55 Evaluation of avoralstat, an oral kallikrein inhibitor, in a Phase ...
https://profiles.wustl.edu/en/publications/evaluation-of-avoralstat-an-oral-kallikrein-inhibitor-in-a-phase-
Background: Effective inhibition of plasma kallikrein may have significant benefits for patients with hereditary angioedema due to deficiency of C1 inhibitor ( ...
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56 A020 A PHASE 2 STUDY EVALUATING AN ANTISENSE ...
https://www.annallergy.org/article/S1081-1206(21)00597-4/fulltext
Hereditary angioedema (HAE) is a rare genetic disease characterized by a ... The kallikrein-kinin system has been demonstrated to play a central role in the ...
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57 Hereditary Angioedema
https://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/allergy/hereditary-angioedema/
Hereditary angioedema (HAE) is an inherited condition characterized by recurrent ... Hageman factor, kallikrein, and plasmin, as illustrated in (Figure 1).
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58 Current and Emerging Therapies to Prevent Hereditary ...
https://www.ajmc.com/view/current-and-emerging-therapies-to-prevent-hae-attacks
Prior to 2008, treatment options for hereditary angioedema (HAE) in the ... Kallikrein is formed through activation of prekallikrein by ...
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59 Hereditary Angioedema Treatments Therapeutic Class ...
https://www.hhs.texas.gov/sites/default/files/documents/about-hhs/communications-events/meetings-events/dur/apr-2021-durb-agenda-item3s.pdf
In HAE, normal regulation of plasma kallikrein activity and the classical complement cascade is not present; thus, during HAE attacks, ...
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60 Oral Plasma Kallikrein Inhibitor for ... - ResearchGate
https://www.researchgate.net/publication/326633737_Oral_Plasma_Kallikrein_Inhibitor_for_Prophylaxis_in_Hereditary_Angioedema
Background Hereditary angioedema is a life-threatening illness caused by mutations in the gene encoding C1 inhibitor (also called C1 ...
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61 plasma kallikrein inhibitors and uses thereof for treating ...
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020047352
Provided herein are methods of treating and preventing hereditary angioedema attack in certain human patient subpopulations using antibodies ...
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62 Hereditary Angioedema
http://www.uky.edu/~achan2/pics/med/hae-clinical-case.pdf
Attacks of hereditary angioedema usually follow a predictable course. Many ... proteases (plasma kallikrein and coagulation fac-.
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63 Hereditary Angioedema - BINASSS
https://www.binasss.sa.cr/feb22/31.pdf
Targeted treatment for acute HAE attacks focuses on decreasing the production of bra- dykinin through inhibition of kallikrein, and replacement of C1-INH, or by ...
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64 Hereditary angioedema: Long-term prophylactic treatment
https://www.ingentaconnect.com/content/ocean/aap/2020/00000041/a00106s1/art00009
Additional options, such as oral kallikrein inhibitor, antisense RNA/plasma kallikrein, anti-Factor 12a, bradykinin receptor blocker or future ...
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65 Drugs Used in Hereditary Angioedema | DrugBank Online
https://go.drugbank.com/categories/DBCAT002563
Drug, Drug Description. Ecallantide, A kallikrein inhibitor used to prevent and treat acute attacks caused by Hereditary Angioedema (HAE).
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66 BioCryst Advances Second Generation Oral Plasma Kallikrein ...
https://ir.biocryst.com/news-releases/news-release-details/biocryst-advances-second-generation-oral-plasma-kallikrein
... Oral Plasma Kallikrein Inhibitors for Hereditary Angioedema into ... oral treatments for the prevention of hereditary angioedema (HAE) ...
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67 Intellia Therapeutics Announces Positive Interim Clinical Data ...
https://ir.intelliatx.com/news-releases/news-release-details/intellia-therapeutics-announces-positive-interim-clinical-data
... NTLA-2002 for the Treatment of Hereditary Angioedema (HAE) ... a 65% and 92% mean plasma kallikrein reduction at 25 mg and 75 mg doses, ...
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68 Hereditary Angioedema - Immunology - Medbullets Step 1
https://step1.medbullets.com/immunology/105011/hereditary-angioedema
C1 esterase inhibitor deficiency. C1 esterase inhibitor inhibits kallikrein-kinin pathway. remember kallikrein activates bradykinin; bradykinin.
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69 Hereditary Angioedema: Diagnostic Algorithm and Current ...
https://journals.lww.com/idoj/Fulltext/2021/12060/Hereditary_Angioedema__Diagnostic_Algorithm_and.2.aspx
Hereditary angioedema (HAE) is an uncommon disorder with a global ... kininogen (HMWK) is cleaved by activated factor XII and kallikrein to form bradykinin.
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70 Astria Therapeutics begins Phase Ia hereditary angioedema trial
https://www.clinicaltrialsarena.com/news/astria-phase-ia-hereditary-angioedema/
Astria has began Phase Ia clinical trial of monoclonal antibody inhibitor of plasma kallikrein, STAR-0215, to treat hereditary angioedema.
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71 Ecallantide for the treatment of acute attacks of hereditary ...
https://www.openaccessjournals.com/articles/ecallantide-for-the-treatment-of-acute-attacks-of-hereditary-angioedema-due-to-c1inhibitor-deficiency.pdf
Keywords: angioedema • clinical trials • ecallantide • plasma kallikrein. Hereditary angioedema (HAE) is a disease characterized by unpredictable, non-.
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72 Hereditary and Acquired Angioedema - Merck Manuals
https://www.merckmanuals.com/professional/immunology-allergic-disorders/allergic,-autoimmune,-and-other-hypersensitivity-disorders/hereditary-and-acquired-angioedema
Hereditary angioedema and acquired angioedema (acquired C1 inhibitor ... of bradykinin because C1 inhibitor inhibits activated kallikrein (required for the ...
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73 Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary ...
https://www.zora.uzh.ch/id/eprint/168172/
BACKGROUND: Hereditary angioedema is a life-threatening illness caused by mutations in the gene encoding C1 inhibitor (also called C1 esterase inhibitor) that ...
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74 New medicine for hereditary angioedema, a rare disease ...
https://www.ema.europa.eu/en/news/new-medicine-hereditary-angioedema-rare-disease-causing-swelling-beneath-skin
Takhzyro is the first monoclonal antibody for the prevention of this disease. It has been designed to recognise and attach to kallikrein ...
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75 Review of hereditary angioedema - LymphoSign Journal
https://lymphosign.com/doi/10.14785/lymphosign-2016-0001
One pathway it affects is the kallikrein–kinin pathway, which results in the generation of bradykinin. Bradykinin is an important mediator of edema. Diagnosis ...
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76 hereditary angioedema | The Medical Letter Inc.
https://secure.medicalletter.org/taxonomy/term/15348
The FDA has approved lanadelumab-flyo (Takhzyro – Takeda), a subcutaneously-administered plasma kallikrein inhibitor, for prevention of hereditary ...
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77 Hereditary angioedema - Healthing.ca
https://www.healthing.ca/other/hereditary-angioedema
Quincke disease; HAE – Hereditary angioedema; Kallikrein inhibitor – HAE; Bradykinin receptor antagonist – HAE; C1-inhibitors – HAE; ...
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78 Hereditary Angioedema - IntechOpen
https://www.intechopen.com/chapters/54769
Hereditary angioedema (HAE) is an autosomal dominantly inherited orphan disease ... Acute episodes can be treated with C1‐inh concentrates, a kallikrein ...
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79 The genetics of hereditary angioedema: A review
https://www.rarediseasesjournal.com/articles/the-genetics-of-hereditary-angioedema-a-review.html
While our understanding of hereditary angioedema (HAE) has evolved ... plasma kallikrein, and factor XIa from the contact/coagulation system ...
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80 2017 Lana in HAE.pdf - AIR Unimi
https://air.unimi.it/retrieve/handle/2434/550555/962524/2017%20Lana%20in%20HAE.pdf
treatment of hereditary angioedema with C1 inhibitor deficiency. METHODS ... Inhibiting Plasma Kallikrein for Hereditary Angioedema.
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81 Detection of active kallikrein in induced blister fluids of ...
https://rupress.org/jem/article/152/3/742/49018/Detection-of-active-kallikrein-in-induced-blister
Six suction-induced blister fluids obtained from five patients with hereditary angioedema (HAE) contained active kallikrein, whereas only ...
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82 Lanadelumab reduced hereditary angioedema attacks by 88%
https://www.mdedge.com/pediatrics/article/131946/immunology/lanadelumab-reduced-hereditary-angioedema-attacks-88-100
Lanadelumab, a monoclonal antibody that inhibits kallikrein, reduced attacks of hereditary angioedema with C1 inhibitor deficiency by ...
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83 FDA approves kallikrein inhibitor to treat hereditary angioedema
https://academic.oup.com/ajhp/article/67/2/93/5129884
by CA Thompson · 2010 · Cited by 35 —
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84 Novel Medication for Hereditary Angioedema
https://www.jwatch.org/na43495/2017/02/23/novel-medication-hereditary-angioedema
Lanadelumab, a monoclonal antibody inhibitor of kallikrein, might prevent HAE attacks. In an industry-sponsored, phase 1B study, 28 adults with ...
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85 Kallikrein Inhibition and Bradykinin Receptor Antagonism
https://www.worldallergyorganizationjournal.org/article/S1939-4551(19)30498-3/abstract
Current strategies for the treatment of hereditary angioedema (HAE) include targeted inhibition or antagonism of the contact system, ...
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86 Hereditary angioedema | Health Encyclopedia
https://ufhealthjax.org/encyclopedia/content.aspx?contentID=001456&projectTypeID=1
Quincke disease; HAE- Hereditary angioedema; Kallikrein inhibitor-HAE: bradykinin receptor antagonist-HAE; C1-inhibitors-HAE; Hives-HAE.
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87 Hereditary angioedema - A.D.A.M. Health Solutions Demo
http://ahsdemo.adam.com/content.aspx?productid=617&pid=1&gid=001456
Quincke disease; HAE - Hereditary angioedema; Kallikrein inhibitor - HAE; Bradykinin receptor antagonist - HAE; C1-inhibitors - HAE; Hives - HAE.
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88 Hereditary angioedema - Read by QxMD
https://read.qxmd.com/read/16217168/hereditary-angioedema
PURPOSE OF REVIEW: Hereditary angioedema is an autosomal-dominant deficiency of C1 inhibitor--a serpin inhibitor of kallikrein, C1r, C1s, factor XII, ...
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89 NEJM on Twitter: "Attacks of hereditary angioedema result, in ...
https://twitter.com/nejm/status/1505197407855910913?lang=en
Attacks of hereditary angioedema result, in part, from overactivity of kallikrein. The investigational drug donidalorsen inhibits ...
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90 Hereditary Angioedema: Causes, Symptoms, and Treatment
https://www.ankitparakh.com/hereditary-angioedema-causes-symptoms-and-treatment/
Newer medicines like C1-inhibitor concentrate, bradykinin or kallikrein receptor antagonist are also used. These drugs are quite expensive and ...
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91 Medical Animation: Hereditary Angioedema - Barone Rocks
https://baronerocks.com/index.php/mnemonics/mnemonics-biochemisty/69-medical-animation-hereditary-angioedema
C1-INH is one of the major inhibitors of plasma kallikrein, the protease that cleaves kininogen and releases bradykinin. 3. What peptide is thought to play a ...
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92 BioCryst Says ORLADEYO Approved By Israeli Ministry Of ...
https://www.rttnews.com/3328196/biocryst-says-orladeyo-approved-by-israeli-ministry-of-health-to-prevent-hereditary-angioedema.aspx
... (berotralstat) to prevent attacks of hereditary angioedema (HAE) in ... HAE attacks by decreasing the activity of plasma kallikrein.
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93 Hereditary angioedema, causes, symptoms, diagnosis ...
https://healthjade.net/hereditary-angioedema/
Treatment for acute attacks in hereditary angioedema types 1 and 2 includes replacement with C1 inhibitor concentrates, a kallikrein inhibitor, or fresh-frozen ...
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