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1 Fasting Intact Proinsulin Is a Highly Specific Predictor of ...
https://diabetesjournals.org/care/article/27/3/682/23055/Fasting-Intact-Proinsulin-Is-a-Highly-Specific
CONCLUSIONS—Elevated intact proinsulin seems to indicate an advanced stage of β-cell exhaustion and is a highly specific marker for insulin ...
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2 Proinsulin, Intact | ARUP Laboratories Test Directory
https://ltd.aruplab.com/Tests/Pub/0070112
Fasting intact proinsulin values above the reference interval indicate a possible insulin secreting pancreatic tumor (insulinoma) in patients with ...
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3 Insulin, C-peptide and proinsulin for the biochemical ...
https://eje.bioscientifica.com/view/journals/eje/157/1/1570075.xml
When fasting blood glucose levels reached 2.5–3.3 mmol/l, proinsulin was <22 pmol/l in all the controls and >22 pmol/l in 74% of the patients.
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4 Intact Proinsulin (TECO®) - Diabetes & Obesity - TECOmedical
https://www.tecomedical.com/en/Diagnostic-Assays-Reagents/Diabetes-Obesity/Intact-Proinsulin-TECO/
In clinical practice, fasting morning intact proinsulin can be used as highly specific indicator of clinically relevant insulin resistance, to serve as the ...
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5 Fasting Proinsulin Independently Predicts Incident Type 2 ...
https://www.mdpi.com/2075-4426/12/7/1131/htm
Fasting proinsulin levels may serve as a marker of β-cell dysfunction and predict type 2 diabetes (T2D) development. Kidneys have been found to be a major ...
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6 Both Fasting and Glucose-Stimulated Proinsulin Levels ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124028
Fasting proinsulin, proinsulin at 30 min and proinsulin AUC during the first 30 min of an oral glucose tolerance test significantly predicted ...
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7 Proinsulin-to-C-peptide ratio versus proinsulin-to-insulin ratio ...
https://link.springer.com/article/10.1007/s00125-011-2322-2
The objective of this paper was to compare fasting intact and split proinsulin-to-insulin ratios (PI/I, SPI/I) with intact and split ...
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8 Insulin, Intact and Split Proinsulin, and Coronary Artery ...
https://www.ahajournals.org/doi/full/10.1161/01.cir.92.6.1422
Methods and Results Specific two-site immunoradiometric assays were used to distinguish intact proinsulin, (des 31,32)proinsulin, and “true” insulin in fasting ...
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9 Role of Intact Proinsulin in Diagnosis and Treatment of Type 2 ...
https://www.liebertpub.com/doi/10.1089/152091504774198124
Therefore, patients with increased fasting intact proinsulin values should be treated with a therapy focusing on insulin resistance. Assessment of β-cell ...
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10 Diagnosis of Fasting Hypoglycemia Due to an Islet-Cell Tumor ...
https://academic.oup.com/jcem/article/88/4/1464/2845129
Because proinsulin cross-reacts with insulin in older insulin assays, C-peptide or proinsulin should be measured to rule out a proinsulin-secreting islet-cell ...
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11 Correlation between fasting intact proinsulin values and the ...
https://www.researchgate.net/figure/Correlation-between-fasting-intact-proinsulin-values-and-the-insulin-sensitivity-index_fig1_6602170
Elevation of fasting proinsulin, as a clinical biomarker of insulin resistance, is very closely correlated to insulin resistance, assessed by ...
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12 Proinsulin, Plasma - Mayo Clinic Laboratories
https://pediatric.testcatalog.org/show/PINS
Normal individuals will have proinsulin concentrations below the upper limit of the normal fasting reference range (22 pmol/L) when hypoglycemic (blood glucose ...
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13 Proinsulin (Blood) - Health Encyclopedia - URMC
https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=proinsulin_blood
You may need to fast overnight before you take the test, although the fasting time period before the test varies. Your healthcare provider will give you ...
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14 Medline ® Abstract for Reference 21 of 'Pathogenesis of type ...
https://www.uptodate.com/contents/pathogenesis-of-type-2-diabetes-mellitus/abstract/21
23 +/- 2%, and OD versus OC: 28 +/- 4 vs. 16 +/- 2%, both P<0.01. In obese normal subjects, intact proinsulin/PIM was lower both in the fasting state and after ...
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15 Insulin, Intact, LC/MS/MS | Test Summary | Quest Diagnostics
https://testdirectory.questdiagnostics.com/test/test-guides/TS_Insulin_Intact/insulin-intact-lcmsms
Elevated fasting intact insulin levels (>16 μIU/mL) may be seen in patients with insulinoma, exogenous insulin, or type 2 DM (Table).
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16 Proinsulin to insulin ratio is associated with incident type 2 ...
https://drc.bmj.com/content/8/1/e001425
PIR was associated with fasting glucose (β per SD: 0.11±0.02; ... Fasting intact proinsulin is a highly specific predictor of insulin resistance in type 2 ...
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17 Fasting Intact Proinsulin Is a Highly Specific ... - EBSCO
https://search.ebscohost.com/login.aspx?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=01495992&AN=12420717&h=GC61VFKm4J521NftWBDAj%2BZ3vnYOVf0dGIJBZlgOhevO50fR9EV%2F8vsRkPzDaUYQjaF4RFSH7cuXkM43zMzNeQ%3D%3D&crl=f
tolerance test and determination of fasting values of intact proinsulin, insulin, resistin, adiponec- tin, and glucose. Insulin resistance was determined by ...
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18 140533: Proinsulin - Labcorp
https://www.labcorp.com/tests/140533/proinsulin
Baseline proinsulin levels should be collected after a 12-hour fast. Causes for Rejection. Nonfrozen specimen; nonserum specimen; gross hemolysis; gross lipemia ...
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19 [PDF] Fasting intact proinsulin is a highly specific predictor of insulin ...
https://www.semanticscholar.org/paper/Fasting-intact-proinsulin-is-a-highly-specific-of-2-Pf%C3%BCtzner-Kunt/22b2278d611f435fec6dcb39d5e293949cc76fc8
Elevation of fasting intact proinsulin seems to be the more specific marker for insulin resistance and increased cardiovascular risk than suppression of ...
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20 The effect of different volumes of high-intensity interval training ...
https://paulogentil.com/pdf/The%20effect%20of%20different%20volumes%20of%20high-intensity%20interval%20training%20on%20proinsulin%20in%20participants%20with%20the%20metabolic%20syndrome%20-%20a%20randomised%20trial.pdf
Fasting intact proinsulin concentration was also expressed relative to insulin and C-peptide concentrations. Results Following the exercise training, ...
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21 Intact proinsulin level is associated with insulin resistance but ...
https://www.endocrine-abstracts.org/ea/0041/ea0041gp75
Glucose (0, 30, 60, 90, 120 min), insulin (0, 30, 60, 90, 120 min), C-peptide (0, 30 min), and fasting intact proinsulin were measured and insulin ...
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22 Proinsulin - UI Health Care
https://www.healthcare.uiowa.edu/path_handbook/handbook/test2382.html
Normal individuals will have proinsulin concentrations below the upper limit of the normal fasting reference range (22 pmol/L) when ...
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23 TECO® Intact Proinsulin ELISA - Diapharma
https://diapharma.com/product/biomarkers/liver_biomarkers/nafld-livbio/insulin-nafld-livbio/teco-intact-proinsulin-elisa/
Proinsulin is produced in the pancreatic ß-cells and is normally further processed to insulin and C-peptide. It is only seen in low concentrations in the plasma ...
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24 Elevated Intact Proinsulin Levels During an Oral Glucose ...
https://www.invitron.com/elevated-intact-proinsulin-levels/
Elevated fasting intact proinsulin is a biomarker of late-stage ß-cell-dysfunction associated with clinically relevant insulin resistance.
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25 The Korean Journal of Internal Medicine
https://www.kjim.org/journal/view.php?number=8007
Proinsulin/insulin ratio was positively correlated with fasting C-peptide (r = 0.236, p = 0.031), fasting blood glucose (r = 0.264, p = 0.015), ...
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26 K 7821 - Intact Proinsulin ELISA - Immundiagnostik
https://www.immundiagnostik.com/en/testkits/k-7821
The joint determination of fasting insulin and fasting intact proinsulin allows a pathophysiological staging of type 2 diabetes based on β-cell secretion.
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27 (PDF) Fasting Intact Proinsulin Is a Highly ... - Academia.edu
https://www.academia.edu/14413169/Fasting_Intact_Proinsulin_Is_a_Highly_Specific_Predictor_of_Insulin_Resistance_in_Type_2_Diabetes?from_sitemaps=true
Fasting Intact Proinsulin Is a Highly Specific Predictor of Insulin Resistance in Type 2 Diabetes.
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28 The proinsulin/insulin (PI/I) ratio is reduced by postprandial ...
https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-6-453
Plasma glucose and insulin were measured at 0 (fasting), 30, 60, 120, and 180 min. ... Gama et al. reported that fasting intact proinsulin ...
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29 Specific insulin and proinsulin in normal glucose tolerant first ...
https://www.scielo.br/j/bjmbr/a/8LjJYRbyxvDLptn3KwNK4Km/?lang=en
When these groups were stratified according to BMI, the obese FDR (N = 8) showed higher fasting and post-glucose insulin levels than the obese NGT (N = 9) ( ...
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30 Genome-wide association study of fasting proinsulin, fasting ...
https://journals.viamedica.pl/endokrynologia_polska/article/view/EP.a2022.0054
Pfützner A, Kunt T, Hohberg C, et al. Fasting intact proinsulin is a highly specific predictor of insulin resistance in type 2 diabetes.
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31 Marker for the diagnosis of an insulin resistance | Bioscientia
https://www.bioscientia.info/en/files/2011/10/Marker-for-the-diagnosis-of-an-insulin-resistance.pdf
HOMA Index and intact proinsulin ... In doing so the determination of fasting insulin. (= control variable) and fasting blood sugar val-.
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32 TECO® Proinsulin - Quidel
https://www.quidel.com/sites/default/files/product/documents/teco_proinsulin.pdf
Fasting intact proinsulin is a highly specific indicator of insulin resistance in type 2 Diabetes. Diabetes Care 27: 682-687, 2004.
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33 Specific insulin and proinsulin concentrations in nondiabetic ...
https://www.sciencedirect.com/science/article/pii/S0026049598902268
Plasma SI and PI levels were measured in fasting and 30-minute and 120-minute samples of a glucose tolerance test (World Health Organization criteria) using ...
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34 IV2-102E Invitron Intact Proinsulin ELISA Kit - IBL-America
https://www.ibl-america.com/content/elisa/IV2-102E.pdf
The Invitron Intact Proinsulin ELISA kit is an immunometric assay for the ... Determinations of fasting values of intact proinsulin, insulin, resistin,.
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35 Proinsulin-to-C-Peptide Ratio Versus Proinsulin-to-Insulin ...
https://professional.diabetes.org/abstract/proinsulin-c-peptide-ratio-versus-proinsulin-insulin-ratio-prediction-incident-type-2
Our objective, therefore, was to compare fasting intact and split PI-to-insulin ratios (PI/I, SPI/I) with intact and split PI-to-C-peptide ratios (PI/C-pep, ...
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36 Improvement in the proinsulin/C-peptide ratio during treatment ...
https://www.tandfonline.com/doi/full/10.1080/14656566.2018.1459258
In this study, fasting insulin, C-peptide, and proinsulin levels ... Pfützner A, Forst T. Elevated intact proinsulin levels are indicative ...
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37 Disproportionately Elevated Fasting Proinsulin Levels in ...
https://www.karger.com/Article/Abstract/68572
Results: Fasting proinsulin (p < 0.002) and proinsulin-to-insulin ratio (p < 0.02) were significantly increased in patients with thalassemia irrespective of the ...
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38 Evolution of Relationship between Increased Demand of ...
https://www.texilajournal.com/medicine/article/256-evolution-of-relationship
Elevated intact proinsulin seems to indicate an advanced stage of β-cell exhaustion and is a highly specific marker for insulin resistance. It might be used as ...
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39 Importance of Validation of Immunoassays for Intact Proinsulin
https://www.degruyter.com/document/doi/10.1515/CCLM.2001.102/html
The aim of this study was to compare results obtained from two commercially available immunoassay kits for intact proinsulin. Fasting and ...
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40 The effect of different volumes of high-intensity ... - UQ eSpace
https://espace.library.uq.edu.au/view/UQ:400946
Fasting intact proinsulin concentration was also expressed relative to insulin and C-peptide concentrations. ... There were no significant (p > ...
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41 Fasting Intact Proinsulin Is a Highly Specific Predictor of ...
https://pub.h-brs.de/frontdoor/index/index/year/2018/docId/3685
Fasting Intact Proinsulin Is a Highly Specific Predictor of Insulin Resistance in Type 2 Diabetes ... OBJECTIVE—In later stages of type 2 diabetes, proinsulin and ...
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42 Determinants of Plasminogen Activator Inhibitor-1 Activity in ...
https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0038-1653762.pdf
RIA, fasting plasma insulin (EIMA) by specific two site immuno- enzymometric assay, and intact proinsulin and des-31,32-proinsulin by.
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43 Proinsulin - Wikipedia
https://en.wikipedia.org/wiki/Proinsulin
There are higher concentrations of proinsulin after meals and lower levels when a person is fasting. ... Additionally, while proinsulin and insulin have ...
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44 Diabetes & Obesity Protein Biomarkers - ALPCO
https://www.alpco.com/wp-content/uploads/2022/04/DO-Biomarker-Brochure_26APR22.pdf
Proinsulin is a precursor molecule produced by pancreatic ß-cells, ... Further, they suggest measurement of fasting intact proinsulin may ...
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45 Technical Note The cross reaction of Proinsulin metabolites in ...
https://fnkprddata.blob.core.windows.net/domestic/download/pdf/TN34-0115_The_cross_reaction_of_Proinsulin_metabolites_in_the_Mercodia_Proinsulin2.pdf
Intact proinsulin was 2.3±0.3 pM and split (32-33) proinsulin was 2.1±0.7 pM in the fasting state of the eight normal subjects and 9.9±1.4 pM and.
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46 The proinsulin/insulin (PI/I) ratio is reduced by postprandial ...
https://cyberleninka.org/article/n/1190307
Pfützner A, Kunt T, Hohberg C, Mondok A, Pahler S, Konrad T, Lübben G, Forst T: Fasting intact proinsulin is a highly specific predictor of insulin resistance ...
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47 Pro-insulin, C Peptide, Glucagon, Adiponectin, TNFa, AMPK
https://www.japi.org/s2b4a454/pro-insulin-c-peptide-glucagon-adiponectin-tnfa-ampk-neglected-players-in-type-2-diabetes-mellitus
Studies with I-123 labeled human proinsulin (HPI) have shown that intact HPI is ... C Peptide is a measure of endogenous insulin secretion, Normal fasting ...
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48 Effect of vildagliptin compared to glimepiride on postprandial ...
https://www.medscape.org/medline/abstract/23384119
This study compared the effect of Glimepiride versus Vildagliptin on β-cell function and the release of intact proinsulin (PI) in patients with type 2 ...
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49 Limitations of the fasting proinsulin to insulin ratio as a measure of β ...
https://clic-ctsa.org/publications/limitations-fasting-proinsulin-insulin-ratio-measure-b-cell-health-people-and-without
The fasting proinsulin to insulin ratio is elevated in people with type 2 diabetes and has been suggested as a marker of β-cell health.
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50 Insulin Fasting | Blood Test - Life Extension
https://www.lifeextension.com/lab-testing/itemlc004333/insulin-fasting-blood-test
Fasting insulin levels may be elevated in people with insulin resistance and type 2 diabetes, but they may be abnormally low for those with type 1 diabetes ...
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51 Proinsulin Blood Test | Walk-In Lab
https://www.walkinlab.com/products/view/proinsulin-blood-test
Fasting for 8-10 hours required. Test Results: Description. Proinsulin. Order a proinsulin blood test to help evaluate if your body ...
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52 How to Lower Your Insulin Levels - Healthline
https://www.healthline.com/nutrition/14-ways-to-lower-insulin
The researchers found that consuming ACV significantly decreased fasting blood sugar and HbA1C (a measure of blood sugar over time).
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53 Diabetes and Intermittent Fasting - Verywell Health
https://www.verywellhealth.com/diabetes-and-intermittent-fasting-4844452
Learn what the medical research says about the safety and effectiveness of popular intermittent fasting diets for those with diabetes.
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54 What are normal levels of insulin and why don't we test it more?
https://www.levelshealth.com/blog/what-are-normal-insulin-levels-and-why-dont-we-test-it-more
There isn't a scientific consensus on optimal insulin levels. However, summarized comments from five Levels advisors suggest that fasting ...
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55 Fasting | Peripheral Insulin Resistance- Thomas DeLauer
https://www.youtube.com/watch?v=wFZnZvNiEBo
Thomas DeLauer
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56 Intermittent Fasting with Type 1 Diabetes
https://diabetesstrong.com/intermittent-fasting-type-1-diabetes/
Periodic fast: You suddenly decide to go 24 hours without eating, unrelated to your fasting or eating schedule throughout the rest of week. I ...
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57 Protein Precursors: Advances in Research and Application: ...
https://books.google.com/books?id=AxQObBzTUCwC&pg=PA161&lpg=PA161&dq=fasting+intact+proinsulin&source=bl&ots=KbXPq5xAWF&sig=ACfU3U3VOhy0YhwGqAHTDMtCxM_zl6uEnw&hl=en&sa=X&ved=2ahUKEwiZmdnE09_7AhWPmWoFHXqEDNYQ6AF6BQjkARAD
Fasting concentrations of total and intact proinsulin were similar in patients with normal, impaired (including two cases of impaired fasting glucose) and ...
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58 Endocrine System Diseases: New Insights for the Healthcare ...
https://books.google.com/books?id=JgrJ2In2rYkC&pg=PT101&lpg=PT101&dq=fasting+intact+proinsulin&source=bl&ots=Yl8Jp6wTiV&sig=ACfU3U3hy-oNzP66A75y61lhbDSOPYLTuw&hl=en&sa=X&ved=2ahUKEwiZmdnE09_7AhWPmWoFHXqEDNYQ6AF6BQjrARAD
Blood samples were taken for the measurement of fasting glucose, HbAlC , fasting insulin, intact proinsulin, adiponectin and Hct (haematocrit).
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59 Diabetology of Pregnancy - Page 31 - Google Books Result
https://books.google.com/books?id=JQKb4xG2_ScC&pg=PA31&lpg=PA31&dq=fasting+intact+proinsulin&source=bl&ots=D_SJ9TtnwV&sig=ACfU3U0DS6H57dljRRDIhOND7gv67My8gw&hl=en&sa=X&ved=2ahUKEwiZmdnE09_7AhWPmWoFHXqEDNYQ6AF6BQjzARAD
... increased fasting serum proinsulin concentrations, molar proinsulin/insulin ratios and 32,33 split proinsulin levels as well as higher stimulated intact ...
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