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Google Keyword Rankings for : avastin hypertension mechanism
1
Expert recommendations on the management of hypertension ...
https://www.nature.com/articles/s41416-019-0481-y
Hypertension that develops during bevacizumab therapy typically resolves after the treatment course of bevacizumab is complete. One study in ...
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https://www.nature.com/articles/s41416-019-0481-y
Hypertension that develops during bevacizumab therapy typically resolves after the treatment course of bevacizumab is complete. One study in ...
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2
Management of Antiangiogenic Therapy-Induced Hypertension
https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.112.196774
Clinical studies have reported effective BP control with these antihypertensive agents. ... In a retrospective review of 154 patients treated with ...
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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.112.196774
Clinical studies have reported effective BP control with these antihypertensive agents. ... In a retrospective review of 154 patients treated with ...
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3
Increased Risk of High-Grade Hypertension With ...
https://academic.oup.com/ajh/article/23/5/460/134424
Our study has demonstrated that bevacizumab is associated with a significantly increased risk of high-grade hypertension, with an incidence of ...
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https://academic.oup.com/ajh/article/23/5/460/134424
Our study has demonstrated that bevacizumab is associated with a significantly increased risk of high-grade hypertension, with an incidence of ...
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4
Hypertension in cancer patients treated with anti-angiogenic ...
https://cardiooncologyjournal.biomedcentral.com/articles/10.1186/s40959-015-0009-4
published a consensus statement on the management of hypertension in patients receiving bevacizumab for ovarian and cervical cancer [51]. They ...
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https://cardiooncologyjournal.biomedcentral.com/articles/10.1186/s40959-015-0009-4
published a consensus statement on the management of hypertension in patients receiving bevacizumab for ovarian and cervical cancer [51]. They ...
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5
Bevacizumab-induced hypertension as a predictor of clinical ...
https://www.cancertreatmentreviews.com/article/S0305-7372(21)00174-2/fulltext
Retrospective series suggest that bevacizumab-induced hypertension (HTN) is a prognostic and potentially predictive biomarker of efficacy of ...
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https://www.cancertreatmentreviews.com/article/S0305-7372(21)00174-2/fulltext
Retrospective series suggest that bevacizumab-induced hypertension (HTN) is a prognostic and potentially predictive biomarker of efficacy of ...
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6
Incidence and Risk of Hypertension in Cancer Patients ...
https://www.frontiersin.org/articles/10.3389/fonc.2021.726008/full
According to the drug label information for bevacizumab, there is a higher incidence of severe hypertension in patients who received bevacizumab ...
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https://www.frontiersin.org/articles/10.3389/fonc.2021.726008/full
According to the drug label information for bevacizumab, there is a higher incidence of severe hypertension in patients who received bevacizumab ...
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7
Management of hypertension in angiogenesis inhibitor-treated ...
https://www.sciencedirect.com/science/article/pii/S0923753419408120
In patients on bevacizumab, HTN had an overall incidence of up to 32% [5]; 11%–16% of patients required intensive therapy with multiple drugs (grade 3), but ...
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https://www.sciencedirect.com/science/article/pii/S0923753419408120
In patients on bevacizumab, HTN had an overall incidence of up to 32% [5]; 11%–16% of patients required intensive therapy with multiple drugs (grade 3), but ...
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8
Investigation of drugs affecting hypertension in bevacizumab ...
https://onlinelibrary.wiley.com/doi/10.1002/cam4.3587
Bevacizumab is a humanized monoclonal antibody against the vascular endothelial growth factor (VEGF) that inhibits tumor growth by inhibiting ...
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https://onlinelibrary.wiley.com/doi/10.1002/cam4.3587
Bevacizumab is a humanized monoclonal antibody against the vascular endothelial growth factor (VEGF) that inhibits tumor growth by inhibiting ...
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9
Vascular Endothelial Growth Factor Inhibitor-Induced ...
https://www.hindawi.com/journals/crp/2011/816897/
Also, diagnosis and treatment of hypertension induced by vascular ... Bevacizumab was the first anti-VEGF monoclonal antibody approved for clinical practice ...
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https://www.hindawi.com/journals/crp/2011/816897/
Also, diagnosis and treatment of hypertension induced by vascular ... Bevacizumab was the first anti-VEGF monoclonal antibody approved for clinical practice ...
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10
Bevacizumab-Induced Hypertension | SpringerLink
https://link.springer.com/article/10.2165/11590180-000000000-00000
It is suggested that bevacizumab-induced inhibition of VEGF leads to decreased synthesis of NO.[50] Consequences of this decreased synthesis are ...
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https://link.springer.com/article/10.2165/11590180-000000000-00000
It is suggested that bevacizumab-induced inhibition of VEGF leads to decreased synthesis of NO.[50] Consequences of this decreased synthesis are ...
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11
Clinical management of hypertension induced by treatment ...
https://oncologypro.esmo.org/content/download/22276/368732/1/Clinical-Management-hypertension-Spano-Delamotterouge.pdf
Understand the mechanisms of hypertension (HTN) ... Incidence of hypertension in selected phase III trials of bevacizumab. Disease Author. Regimen. Patient,.
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https://oncologypro.esmo.org/content/download/22276/368732/1/Clinical-Management-hypertension-Spano-Delamotterouge.pdf
Understand the mechanisms of hypertension (HTN) ... Incidence of hypertension in selected phase III trials of bevacizumab. Disease Author. Regimen. Patient,.
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12
Correlation of Hypertension and Proteinuria with Outcome in ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116527
Several studies have suggested a relationship between the development of hypertension, a common side effect of bevacizumab treatment, and ...
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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116527
Several studies have suggested a relationship between the development of hypertension, a common side effect of bevacizumab treatment, and ...
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13
Avastin® (bevacizumab) Proposed MOA | MCRC Treatment
https://www.avastin.com/hcp/mcrc/proposed-moa.html
About Avastin: Proposed Mechanism of Action · As demonstrated in preclinical models: Avastin directly binds vascular endothelial growth factor (VEGF) to inhibit ...
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https://www.avastin.com/hcp/mcrc/proposed-moa.html
About Avastin: Proposed Mechanism of Action · As demonstrated in preclinical models: Avastin directly binds vascular endothelial growth factor (VEGF) to inhibit ...
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14
Bevacizumab-induced hypertension: pathogenesis and ... - Gale
https://go.gale.com/ps/i.do?id=GALE%7CA258538272&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=11738804&p=AONE&sw=w
The incidence of grade 3-4 hypertension differs among the various malignancies in which bevacizumab is administered, possibly because of drug interactions with ...
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https://go.gale.com/ps/i.do?id=GALE%7CA258538272&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=11738804&p=AONE&sw=w
The incidence of grade 3-4 hypertension differs among the various malignancies in which bevacizumab is administered, possibly because of drug interactions with ...
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15
Bevacizumab-Induced Hypertension as a Potential ... - Cureus
https://www.cureus.com/articles/112173-bevacizumab-induced-hypertension-as-a-potential-physiological-clinical-biomarker-for-improved-outcomes-in-patients-with-recurrent-glioblastoma-multiforme-a-systematic-review
› articles › 112173-bevacizum...
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https://www.cureus.com/articles/112173-bevacizumab-induced-hypertension-as-a-potential-physiological-clinical-biomarker-for-improved-outcomes-in-patients-with-recurrent-glioblastoma-multiforme-a-systematic-review
› articles › 112173-bevacizum...
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16
Hypertension and Neuroimaging Changes After Bevacizumab ...
https://publications.aap.org/pediatrics/article/145/1/e20191814/36998/Hypertension-and-Neuroimaging-Changes-After
Although the specific mechanism for the development of bevacizumab-induced hypertension is not well understood, it is thought to involve ...
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https://publications.aap.org/pediatrics/article/145/1/e20191814/36998/Hypertension-and-Neuroimaging-Changes-After
Although the specific mechanism for the development of bevacizumab-induced hypertension is not well understood, it is thought to involve ...
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17
Bevacizumab significantly increases the risks of hypertension ...
https://www.oncotarget.com/article/18190/text/
Hypertension induced by bevacizumab may involve multiple reasons. Firstly, appropriate VEGF produced by podocytes could activate VEGF receptor ...
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https://www.oncotarget.com/article/18190/text/
Hypertension induced by bevacizumab may involve multiple reasons. Firstly, appropriate VEGF produced by podocytes could activate VEGF receptor ...
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18
Hypertensive Profile of Metastatic Colorectal Carcinoma ...
https://www.scirp.org/journal/paperinformation.aspx?paperid=63903
The blood pressure peaked on 6th day of bevacizumab administration. ... Several mechanisms are proposed for bevacizumab induced hypertension.
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https://www.scirp.org/journal/paperinformation.aspx?paperid=63903
The blood pressure peaked on 6th day of bevacizumab administration. ... Several mechanisms are proposed for bevacizumab induced hypertension.
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19
Hypertension Secondary to Anti-angiogenic Therapy
https://ar.iiarjournals.org/content/anticanres/27/5B/3465.full.pdf
Its incidence, treatment and complications are undefined. Patients and Methods: Retrospective review of patients treated with bevacizumab (BV) from 2003-5.
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https://ar.iiarjournals.org/content/anticanres/27/5B/3465.full.pdf
Its incidence, treatment and complications are undefined. Patients and Methods: Retrospective review of patients treated with bevacizumab (BV) from 2003-5.
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20
review - Management of hypertension in angiogenesis ...
https://www.annalsofoncology.org/article/S0923-7534(19)40812-0/pdf
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003; 349: 427 ...
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https://www.annalsofoncology.org/article/S0923-7534(19)40812-0/pdf
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003; 349: 427 ...
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21
(PDF) Bevacizumab-Induced Hypertension Pathogenesis and ...
https://www.researchgate.net/publication/51179233_Bevacizumab-Induced_Hypertension_Pathogenesis_and_Management
Although the underlying pathophysiological mechanism for antineoplastic related hypertension remains unknown, increase in vascular tone due to inhibition of ...
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https://www.researchgate.net/publication/51179233_Bevacizumab-Induced_Hypertension_Pathogenesis_and_Management
Although the underlying pathophysiological mechanism for antineoplastic related hypertension remains unknown, increase in vascular tone due to inhibition of ...
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22
Hypertension Caused by VEGF-Signaling Pathway Inhibitors
https://jhoponline.com/jhop-issue-archive/2017-issues/jhop-december-2017-vol-7-no-4/17337-hypertension-caused-by-vegf-signaling-pathway-inhibitors
Through this mechanism, VEGF plays a role in nitric oxide production and vasodilation. It has been proposed that when the VEGF-signaling pathway is inhibited, ...
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https://jhoponline.com/jhop-issue-archive/2017-issues/jhop-december-2017-vol-7-no-4/17337-hypertension-caused-by-vegf-signaling-pathway-inhibitors
Through this mechanism, VEGF plays a role in nitric oxide production and vasodilation. It has been proposed that when the VEGF-signaling pathway is inhibited, ...
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23
THE EFFECT OF INTRAVITREAL AVASTIN ON SYSTEMIC ...
https://jag.journalagent.com/ias/pdfs/IAS_21_2_77_80.pdf
avastin treatment is hypertension (6). The mechanism by which the anti-VEGF drugs increase the systemic blood pressure is incompletely understood, but it is.
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https://jag.journalagent.com/ias/pdfs/IAS_21_2_77_80.pdf
avastin treatment is hypertension (6). The mechanism by which the anti-VEGF drugs increase the systemic blood pressure is incompletely understood, but it is.
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24
Guidelines for Bevacizumab Induced Hypertension
http://www.kmcc.nhs.uk/EasySiteWeb/GatewayLink.aspx?alId=467619
Bevacizumab may cause hypertension in patients that are treated with the drug. This is due to the mechanism of action of bevacizumab and its ...
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http://www.kmcc.nhs.uk/EasySiteWeb/GatewayLink.aspx?alId=467619
Bevacizumab may cause hypertension in patients that are treated with the drug. This is due to the mechanism of action of bevacizumab and its ...
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25
Hypertension
https://www.oncology.tv/SymptomManagement/Hypertension
Patients receiving bevacizumab are at increased risk of developing HTN · Bevacizumab-associated hypertension should be treated according to published guidelines ...
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https://www.oncology.tv/SymptomManagement/Hypertension
Patients receiving bevacizumab are at increased risk of developing HTN · Bevacizumab-associated hypertension should be treated according to published guidelines ...
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26
Toxicity of molecularly targeted antiangiogenic agents
https://www.uptodate.com/contents/toxicity-of-molecularly-targeted-antiangiogenic-agents-cardiovascular-effects
Thus, the pathophysiology of the cardiovascular toxicities of vascular endothelial ... Arterial hypertension and bevacizumab treatment in glioblastoma: no ...
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https://www.uptodate.com/contents/toxicity-of-molecularly-targeted-antiangiogenic-agents-cardiovascular-effects
Thus, the pathophysiology of the cardiovascular toxicities of vascular endothelial ... Arterial hypertension and bevacizumab treatment in glioblastoma: no ...
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27
Hypertension and Antiangiogenesis: The Janus Face of VEGF ...
https://www.jacc.org/doi/10.1016/j.jaccao.2019.08.010
Unless gaps in knowledge are addressed and underlying mechanisms better understood, the clinical burden of cardiovascular toxicities in VEGFI- ...
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https://www.jacc.org/doi/10.1016/j.jaccao.2019.08.010
Unless gaps in knowledge are addressed and underlying mechanisms better understood, the clinical burden of cardiovascular toxicities in VEGFI- ...
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28
Drug induced hypertension – An unappreciated cause of ...
https://www.eshonline.org/esh-content/uploads/2019/07/1.-Drug-induced-hypertension-An-unappreciated-cause-of-secondary-hypertension-main1.pdf
Bevacizumab (Avastin) is used to treat metastatic cancers of var- ious origins. ... The mechanism of elevated blood pressure in patients treated.
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https://www.eshonline.org/esh-content/uploads/2019/07/1.-Drug-induced-hypertension-An-unappreciated-cause-of-secondary-hypertension-main1.pdf
Bevacizumab (Avastin) is used to treat metastatic cancers of var- ious origins. ... The mechanism of elevated blood pressure in patients treated.
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29
Drug-induced Hypertension: An Unappreciated Cause of ...
https://www.amjmed.com/article/S0002-9343(11)00476-1/abstract
Therefore, the impact of poorly controlled HTN on cardiovascular morbidity and mortality may become a major issue. Bevacizumab (Avastin) is used to treat ...
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https://www.amjmed.com/article/S0002-9343(11)00476-1/abstract
Therefore, the impact of poorly controlled HTN on cardiovascular morbidity and mortality may become a major issue. Bevacizumab (Avastin) is used to treat ...
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30
Combination Targeted Therapy With Sorafenib and ...
https://ascopubs.org/doi/10.1200/jco.2007.10.8332
Neither thrombocytopenia nor proteinuria recurred after bevacizumab dose reduction. DL1 is the dose level onto which patients in cohort 2 were ...
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https://ascopubs.org/doi/10.1200/jco.2007.10.8332
Neither thrombocytopenia nor proteinuria recurred after bevacizumab dose reduction. DL1 is the dose level onto which patients in cohort 2 were ...
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31
A mechanism of arterial hypertension induced by anti-VEGF ...
https://aacrjournals.org/cancerres/article/67/9_Supplement/1624/535872/A-mechanism-of-arterial-hypertension-induced-by
Background: Bevacizumab (Bv) has demonstrated a survival advantage in combination with chemotherapy for patients with metastatic colorectal ...
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https://aacrjournals.org/cancerres/article/67/9_Supplement/1624/535872/A-mechanism-of-arterial-hypertension-induced-by
Background: Bevacizumab (Bv) has demonstrated a survival advantage in combination with chemotherapy for patients with metastatic colorectal ...
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32
Cancer therapy and cardiovascular risk: focus on bevacizumab
https://www.dovepress.com/cancer-therapy-and-cardiovascular-risk-focus-on-bevacizumab-peer-reviewed-fulltext-article-CMAR
Keywords: bevacizumab, cardiovascular toxicity, hypertension. ... The mechanism of bevacizumab therapy-related HTN is not fully understood.
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https://www.dovepress.com/cancer-therapy-and-cardiovascular-risk-focus-on-bevacizumab-peer-reviewed-fulltext-article-CMAR
Keywords: bevacizumab, cardiovascular toxicity, hypertension. ... The mechanism of bevacizumab therapy-related HTN is not fully understood.
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33
Successful rechallenge of bevacizumab after grade 4 ...
https://gsconlinepress.com/journals/gscbps/sites/default/files/GSCBPS-2021-0161.pdf
Treatment of multi-resistant ovarian cancer is palliative. ... bevacizumab and patient did not had any hypertensive episode and is doing ...
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https://gsconlinepress.com/journals/gscbps/sites/default/files/GSCBPS-2021-0161.pdf
Treatment of multi-resistant ovarian cancer is palliative. ... bevacizumab and patient did not had any hypertensive episode and is doing ...
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34
AVASTIN® (bevacizumab) Label - Accessdata.fda.gov
https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/125085s0169lbl.pdf
Proteinuria [See Dosage and Administration (2.4), Warnings and Precautions (5.8).] The most common adverse reactions observed in Avastin patients at a rate > 10 ...
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https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/125085s0169lbl.pdf
Proteinuria [See Dosage and Administration (2.4), Warnings and Precautions (5.8).] The most common adverse reactions observed in Avastin patients at a rate > 10 ...
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35
Bevacizumab (Intravenous Route) Side Effects - Mayo Clinic
https://www.mayoclinic.org/drugs-supplements/bevacizumab-intravenous-route/side-effects/drg-20068373?p=1
Your blood pressure might get too high while you are receiving this medicine. This may cause headaches, dizziness, or blurred vision. You might ...
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https://www.mayoclinic.org/drugs-supplements/bevacizumab-intravenous-route/side-effects/drg-20068373?p=1
Your blood pressure might get too high while you are receiving this medicine. This may cause headaches, dizziness, or blurred vision. You might ...
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36
Bevacizumab‐induced hypertension: Clinical presentation ...
https://www.semanticscholar.org/paper/Bevacizumab%E2%80%90induced-hypertension%3A-Clinical-and-Li-Kroetz/50bfa444e5617f3adb9102ce18f48e362e7e2e56
Findings suggest that hypertension occurring secondary to bevacizumab treatment in rats may be associated with mechanisms involving renal ...
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https://www.semanticscholar.org/paper/Bevacizumab%E2%80%90induced-hypertension%3A-Clinical-and-Li-Kroetz/50bfa444e5617f3adb9102ce18f48e362e7e2e56
Findings suggest that hypertension occurring secondary to bevacizumab treatment in rats may be associated with mechanisms involving renal ...
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37
Avastin Side Effects: What They Are and How to Manage Them
https://www.healthline.com/health/drugs/avastin-side-effects
High blood pressure. Avastin can increase your blood pressure. If you already have high blood pressure, Avastin could make this worse. Your ...
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https://www.healthline.com/health/drugs/avastin-side-effects
High blood pressure. Avastin can increase your blood pressure. If you already have high blood pressure, Avastin could make this worse. Your ...
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38
Kidney and Blood Pressure Changes in Patients Receiving ...
https://clinicaltrials.gov/ct2/show/NCT00691730
Physiological mechanism behind proteinuria and hypertension induced by ... Patients who are going to start treatment with bevacizumab, VEGF Trap, ...
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https://clinicaltrials.gov/ct2/show/NCT00691730
Physiological mechanism behind proteinuria and hypertension induced by ... Patients who are going to start treatment with bevacizumab, VEGF Trap, ...
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39
Nephrotic Syndrome After Bevacizumab
https://www.ajkd.org/article/S0272-6386(06)01692-1/pdf
phrotic syndrome and hypertension resolved after discontinuation of bevacizumab therapy. The mechanism of bevacizumab-induced glomerulonephritis and ...
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https://www.ajkd.org/article/S0272-6386(06)01692-1/pdf
phrotic syndrome and hypertension resolved after discontinuation of bevacizumab therapy. The mechanism of bevacizumab-induced glomerulonephritis and ...
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40
avastin-epar-scientific-discussion_en.pdf
https://www.ema.europa.eu/en/documents/scientific-discussion/avastin-epar-scientific-discussion_en.pdf
Irinotecan was approved for use in first-line treatment of metastatic CRC in ... hypertension was relatively consistent across all bevacizumab studies, ...
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https://www.ema.europa.eu/en/documents/scientific-discussion/avastin-epar-scientific-discussion_en.pdf
Irinotecan was approved for use in first-line treatment of metastatic CRC in ... hypertension was relatively consistent across all bevacizumab studies, ...
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41
Bevacizumab Increases Risk for Severe Proteinuria in Cancer ...
https://jasn.asnjournals.org/content/21/8/1381
Treatment with the chemotherapeutic agent bevacizumab, a humanized mAb that neutralizes vascular endothelial growth factor, can lead to ...
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https://jasn.asnjournals.org/content/21/8/1381
Treatment with the chemotherapeutic agent bevacizumab, a humanized mAb that neutralizes vascular endothelial growth factor, can lead to ...
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42
Avastin (bevacizumab): Side effects, uses, alternatives, and ...
https://www.medicalnewstoday.com/articles/avastin
At the start of treatment, Avastin is used with two chemotherapy drugs ... who took Avastin with chemotherapy had high blood pressure during treatment.
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https://www.medicalnewstoday.com/articles/avastin
At the start of treatment, Avastin is used with two chemotherapy drugs ... who took Avastin with chemotherapy had high blood pressure during treatment.
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43
Avastin (Bevacizumab): Uses, Dosage, Side Effects ... - RxList
https://www.rxlist.com/avastin-drug.htm
Renal Injury and Proteinuria [see WARNINGS AND PRECAUTIONS]. Nephrotic syndrome. Discontinue Avastin. Proteinuria greater than or equal to 2 grams per 24 hours ...
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https://www.rxlist.com/avastin-drug.htm
Renal Injury and Proteinuria [see WARNINGS AND PRECAUTIONS]. Nephrotic syndrome. Discontinue Avastin. Proteinuria greater than or equal to 2 grams per 24 hours ...
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44
Association of hypertension and treatment outcomes in ...
https://journals.sagepub.com/doi/full/10.1177/1078155217690921
While the mechanism of bevacizumab-induced hypertension is not clearly understood, studies have found that the pharmacological blockage of VEGF ...
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https://journals.sagepub.com/doi/full/10.1177/1078155217690921
While the mechanism of bevacizumab-induced hypertension is not clearly understood, studies have found that the pharmacological blockage of VEGF ...
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45
Investigation of the Pathogenesis and Treatment Efficiency of ...
https://ejurnal-analiskesehatan.web.id/index.php/JAK/article/view/209
Hypertension is a frequent adverse effect of bevacizumab, although its mechanism(s) remain unclear. In this study, our aim was to examine ...
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https://ejurnal-analiskesehatan.web.id/index.php/JAK/article/view/209
Hypertension is a frequent adverse effect of bevacizumab, although its mechanism(s) remain unclear. In this study, our aim was to examine ...
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46
Endostatin lowers blood pressure via nitric oxide and prevents ...
https://www.pnas.org/doi/10.1073/pnas.1203275109
Hypertension is a dose-limiting toxicity for VEGF inhibitors. ... events of bevacizumab and other antiangiogenesis agents have been treatment limiting.
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https://www.pnas.org/doi/10.1073/pnas.1203275109
Hypertension is a dose-limiting toxicity for VEGF inhibitors. ... events of bevacizumab and other antiangiogenesis agents have been treatment limiting.
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47
avastin_prescribing.pdf - Genentech
https://www.gene.com/download/pdf/avastin_prescribing.pdf
Severe hypertension occurred at a higher incidence in patients receiving Avastin as compared to patients receiving chemotherapy alone. Across clinical studies, ...
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https://www.gene.com/download/pdf/avastin_prescribing.pdf
Severe hypertension occurred at a higher incidence in patients receiving Avastin as compared to patients receiving chemotherapy alone. Across clinical studies, ...
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48
Investigation of drugs affecting hypertension in bevacizumab
https://repo.lib.tokushima-u.ac.jp/files/public/11/116288/20210909143811412831/cam_10_1_164.pdf
To investigate the mechanism of effect of bevacizumab in patients using omeprazole, we analyzed a GEO-deposited toxicogenomics microarray ...
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https://repo.lib.tokushima-u.ac.jp/files/public/11/116288/20210909143811412831/cam_10_1_164.pdf
To investigate the mechanism of effect of bevacizumab in patients using omeprazole, we analyzed a GEO-deposited toxicogenomics microarray ...
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49
Avastin, Mvasi (bevacizumab) dosing, indications, interactions ...
https://reference.medscape.com/drug/avastin-mvasi-bevacizumab-342257
This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Your doctor may control your ...
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https://reference.medscape.com/drug/avastin-mvasi-bevacizumab-342257
This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Your doctor may control your ...
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50
Clinical significance of hypertension in patients with different ...
https://www.spandidos-publications.com/10.3892/ol.2021.12576/download
Possible mechanism of hypertension induced by antiangiogenic drugs. ... developed severe hypertension receive bevacizumab treatment.
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https://www.spandidos-publications.com/10.3892/ol.2021.12576/download
Possible mechanism of hypertension induced by antiangiogenic drugs. ... developed severe hypertension receive bevacizumab treatment.
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51
Bevacizumab (Avastin) - Cancer Research UK
https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/bevacizumab
Bevacizumab blocks this protein and stops the cancer from growing blood vessels, so it is starved and can't grow. Treatments that interfere with the development ...
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https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/bevacizumab
Bevacizumab blocks this protein and stops the cancer from growing blood vessels, so it is starved and can't grow. Treatments that interfere with the development ...
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52
Hypertensive Cardiotoxicity in Cancer Treatment—Systematic ...
https://www.mdpi.com/2077-0383/9/10/3346/htm
Outline of the pathophysiology of cancer therapies leading to hypertension. Cancer therapies can have various impacts on the systemic vascular resistance and ...
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https://www.mdpi.com/2077-0383/9/10/3346/htm
Outline of the pathophysiology of cancer therapies leading to hypertension. Cancer therapies can have various impacts on the systemic vascular resistance and ...
→ Check Latest Keyword Rankings ←
53
Treatment-Related Mortality With Bevacizumab in Cancer ...
https://jamanetwork.com/journals/jama/fullarticle/645368
We previously have shown that the risks of gastrointestinal tract perforation, hypertension, and proteinuria with bevacizumab may be dose- ...
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https://jamanetwork.com/journals/jama/fullarticle/645368
We previously have shown that the risks of gastrointestinal tract perforation, hypertension, and proteinuria with bevacizumab may be dose- ...
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54
Influence of Intravitreal Injection of Bevacizumab on Systemic ...
https://www.hellenicjcardiol.org/archive/full_text/2013/6/2013_6_435.pdf
Introduction: The aim of our study was to examine blood pressure (BP) changes in hypertensive and non- hypertensive patients after intravitreal bevacizumab ...
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https://www.hellenicjcardiol.org/archive/full_text/2013/6/2013_6_435.pdf
Introduction: The aim of our study was to examine blood pressure (BP) changes in hypertensive and non- hypertensive patients after intravitreal bevacizumab ...
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55
DRUG NAME: Bevacizumab - BC Cancer
http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Bevacizumab_monograph.pdf
5 Animal studies suggest that the mechanism may be a reduction in glomerular endothelial cell proliferation.34 Patients with a history of hypertension may be at ...
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http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Bevacizumab_monograph.pdf
5 Animal studies suggest that the mechanism may be a reduction in glomerular endothelial cell proliferation.34 Patients with a history of hypertension may be at ...
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56
Vascular Toxicities of Novel Cancer Therapies
https://www.acc.org/latest-in-cardiology/articles/2022/05/23/13/25/vascular-toxicities-of-novel-cancer-therapies
Systemic hypertension is a common vascular toxicity due to vascular ... various mechanisms of action: VEGF antibodies (e.g., bevacizumab), ...
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https://www.acc.org/latest-in-cardiology/articles/2022/05/23/13/25/vascular-toxicities-of-novel-cancer-therapies
Systemic hypertension is a common vascular toxicity due to vascular ... various mechanisms of action: VEGF antibodies (e.g., bevacizumab), ...
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57
The Role of Vascular Endothelial Growth Factor in Pulmonary ...
https://www.atsjournals.org/doi/pdf/10.1165/rcmb.2014-0045TR
Pulmonary arterial hypertension (PAH) is characterized by dysfunctional angiogenesis leading to ... our understanding of the mechanisms of.
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https://www.atsjournals.org/doi/pdf/10.1165/rcmb.2014-0045TR
Pulmonary arterial hypertension (PAH) is characterized by dysfunctional angiogenesis leading to ... our understanding of the mechanisms of.
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58
Hypertension Management in the Era of Targeted Therapies ...
https://www.cancernetwork.com/view/hypertension-management-era-targeted-therapies-cancer
Three such FDA-approved agents are bevacizumab (Avastin), sorafenib (Nexavar), and sunitinib (Sutent). Additional ones that are in clinical ...
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https://www.cancernetwork.com/view/hypertension-management-era-targeted-therapies-cancer
Three such FDA-approved agents are bevacizumab (Avastin), sorafenib (Nexavar), and sunitinib (Sutent). Additional ones that are in clinical ...
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59
Hypertension in Patients with Cancer - SciELO
https://www.scielo.br/j/abc/a/RP5S59w6bvxRdSrJ7ZjMsHd/?lang=en
The mechanism by which these drugs induce hypertension is not completely understood, but can be directly related to the inhibition of vascular endothelial ...
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https://www.scielo.br/j/abc/a/RP5S59w6bvxRdSrJ7ZjMsHd/?lang=en
The mechanism by which these drugs induce hypertension is not completely understood, but can be directly related to the inhibition of vascular endothelial ...
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60
The Effect of Bevacizumab-Related Hypertension on the ...
https://www.ijpsonline.com/articles/the-effect-of-bevacizumabrelated-hypertension-on-the-prognosis-of-patients-with-colorectal-cancer-and-nonsmall-cell-lung-cancer-4529.html
We often use oral antihypertensive drugs to treat hypertension 1 to 2 in clinic [3]. Studies have indicated that the mechanism of bevacizumab concerns with ...
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https://www.ijpsonline.com/articles/the-effect-of-bevacizumabrelated-hypertension-on-the-prognosis-of-patients-with-colorectal-cancer-and-nonsmall-cell-lung-cancer-4529.html
We often use oral antihypertensive drugs to treat hypertension 1 to 2 in clinic [3]. Studies have indicated that the mechanism of bevacizumab concerns with ...
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61
Cardiovascular complications of metastatic colorectal cancer ...
https://jgo.amegroups.com/article/view/27744/html
The underlying mechanism has not been clarified, but hypertension induced by bevacizumab and the effect of blockade of VEGF to the repair of myocardial ...
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https://jgo.amegroups.com/article/view/27744/html
The underlying mechanism has not been clarified, but hypertension induced by bevacizumab and the effect of blockade of VEGF to the repair of myocardial ...
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62
Attachment 1. Product Information for bevacizumab
https://www.tga.gov.au/sites/default/files/auspar-bevacizumab-091214-pi.docx
patients discontinued chemotherapy prematurely, treatment with AVASTIN as a ... The risk of AVASTIN-associated hypertension did not correlate with the ...
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https://www.tga.gov.au/sites/default/files/auspar-bevacizumab-091214-pi.docx
patients discontinued chemotherapy prematurely, treatment with AVASTIN as a ... The risk of AVASTIN-associated hypertension did not correlate with the ...
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63
Bevacizumab: Uses, Interactions, Mechanism of Action
https://go.drugbank.com/drugs/DB00112
› drugs
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https://go.drugbank.com/drugs/DB00112
› drugs
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64
Acute vascular effects of vascular endothelial growth factor...
https://journals.lww.com/jhypertension/Fulltext/2020/02000/Acute_vascular_effects_of_vascular_endothelial.14.aspx
Acute exposure to bevacizumab does not directly cause endothelial vasomotor ... Current anti-hypertensive therapies used for the treatment of patients with ...
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https://journals.lww.com/jhypertension/Fulltext/2020/02000/Acute_vascular_effects_of_vascular_endothelial.14.aspx
Acute exposure to bevacizumab does not directly cause endothelial vasomotor ... Current anti-hypertensive therapies used for the treatment of patients with ...
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65
Managing Hypertension Associated With VEGF Inhibitors
https://www.onclive.com/view/obtn_may_2010_vegf
Panel members, all experts in managing cardiovascular toxicities, determined that hypertension is a “mechanism-based toxic effect” of VEGF ...
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https://www.onclive.com/view/obtn_may_2010_vegf
Panel members, all experts in managing cardiovascular toxicities, determined that hypertension is a “mechanism-based toxic effect” of VEGF ...
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66
Bevacizumab-Induced Hypertension - ProQuest
http://search.proquest.com/openview/b16b7a4e65f0a004d531abe0fdcd9432/1?pq-origsite=gscholar&cbl=28924
Bevacizumab may affect tumor growth through two principal mechanisms. ... Hypertension requiring treatment was more frequent in the bevacizumab arm (0.5% vs ...
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http://search.proquest.com/openview/b16b7a4e65f0a004d531abe0fdcd9432/1?pq-origsite=gscholar&cbl=28924
Bevacizumab may affect tumor growth through two principal mechanisms. ... Hypertension requiring treatment was more frequent in the bevacizumab arm (0.5% vs ...
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67
Hypertension associated with VEGF inhibitors must ... - Healio
https://www.healio.com/news/hematology-oncology/20120427/hypertension-associated-with-vegf-inhibitors-must-be-detected-treated
These agents include bevacizumab (Avastin, Genentech), sorafenib (Nexavar, ... The precise mechanism of this hypertension is not known, ...
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https://www.healio.com/news/hematology-oncology/20120427/hypertension-associated-with-vegf-inhibitors-must-be-detected-treated
These agents include bevacizumab (Avastin, Genentech), sorafenib (Nexavar, ... The precise mechanism of this hypertension is not known, ...
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68
Bevacizumab - EyeWiki - American Academy of Ophthalmology
https://eyewiki.aao.org/Bevacizumab
Bevacizumab (Avastin; manufactured in the United States by Genentech/Roche) is a recombinant humanized monoclonal IgG1 antibody that binds to and inhibits ...
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https://eyewiki.aao.org/Bevacizumab
Bevacizumab (Avastin; manufactured in the United States by Genentech/Roche) is a recombinant humanized monoclonal IgG1 antibody that binds to and inhibits ...
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69
Bevacizumab - Wikipedia
https://en.wikipedia.org/wiki/Bevacizumab
Bevacizumab, sold under the brand name Avastin among others, is a medication used to treat a number of types of cancers and a specific eye disease.
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https://en.wikipedia.org/wiki/Bevacizumab
Bevacizumab, sold under the brand name Avastin among others, is a medication used to treat a number of types of cancers and a specific eye disease.
→ Check Latest Keyword Rankings ←
70
Avastin® Biosimilar | MVASI® (bevacizumab)
https://www.mvasi.com/hcp
Across studies, the most common adverse reactions observed in bevacizumab patients at a rate >10% were: Epistaxis; Headache; Hypertension; Rhinitis; Proteinuria ...
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https://www.mvasi.com/hcp
Across studies, the most common adverse reactions observed in bevacizumab patients at a rate >10% were: Epistaxis; Headache; Hypertension; Rhinitis; Proteinuria ...
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71
Methods of identifying risk of vascular endothelial growth ...
https://patents.justia.com/patent/11028448
The underlying mechanisms of how bevacizumab induces hypertension and ... whether the occurrence of proteinuria shares the same mechanism ...
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https://patents.justia.com/patent/11028448
The underlying mechanisms of how bevacizumab induces hypertension and ... whether the occurrence of proteinuria shares the same mechanism ...
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72
Bevacizumab (Avastin) - American Journal of Neuroradiology
http://www.ajnr.org/content/31/2/235
Proposed Mechanism of Action. Bevacizumab is a humanized monoclonal antibody (initially it came from the mouse) that targets VEGF-A, an isoform ...
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http://www.ajnr.org/content/31/2/235
Proposed Mechanism of Action. Bevacizumab is a humanized monoclonal antibody (initially it came from the mouse) that targets VEGF-A, an isoform ...
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73
Definition of portal hypertension - NCI Dictionary of Cancer ...
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/portal-hypertension
High blood pressure in the vein that carries blood to the liver from the stomach, small and large intestines, spleen, pancreas, and gallbladder.
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https://www.cancer.gov/publications/dictionaries/cancer-terms/def/portal-hypertension
High blood pressure in the vein that carries blood to the liver from the stomach, small and large intestines, spleen, pancreas, and gallbladder.
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74
Correlation of bevacizumab-induced hypertension and ...
https://cyberleninka.org/article/n/1137990
Bevacizumab is commonly used in combination with chemotherapy in the treatment of metastatic colorectal cancer. However, there are currently no predictive or ...
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https://cyberleninka.org/article/n/1137990
Bevacizumab is commonly used in combination with chemotherapy in the treatment of metastatic colorectal cancer. However, there are currently no predictive or ...
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75
bevacizumab - Drug Formulary - Cancer Care Ontario
https://www.cancercareontario.ca/en/drugformulary/drugs/monograph/44071
Patients with a history of hypertension may be at increased risk for the development of proteinuria. This is likely dose-related and may not completely resolve ...
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https://www.cancercareontario.ca/en/drugformulary/drugs/monograph/44071
Patients with a history of hypertension may be at increased risk for the development of proteinuria. This is likely dose-related and may not completely resolve ...
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76
Bevacizumab in clinical practice
http://www.gffcc.org/journal/docs/issue19/ISS19_33-37%20Majid.pdf
Proteinuria: Proteinuria is an established side effect of bevacizumab therapy. It is usually asymptomatic and grade 3 and 4 are rare (1-3%). (8,9) The mechanism ...
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http://www.gffcc.org/journal/docs/issue19/ISS19_33-37%20Majid.pdf
Proteinuria: Proteinuria is an established side effect of bevacizumab therapy. It is usually asymptomatic and grade 3 and 4 are rare (1-3%). (8,9) The mechanism ...
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77
Avastin intravenous: Uses, Side Effects, Interactions ... - WebMD
https://www.webmd.com/drugs/2/drug-78649/avastin-intravenous/details
› avastin-intravenous › details
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https://www.webmd.com/drugs/2/drug-78649/avastin-intravenous/details
› avastin-intravenous › details
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78
Avastin 25mg/ml concentrate for solution for infusion - (emc)
https://www.medicines.org.uk/emc/product/3885/smpc
Patients with a history of hypertension may be at increased risk for the development of proteinuria when treated with Avastin. There is evidence suggesting that ...
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https://www.medicines.org.uk/emc/product/3885/smpc
Patients with a history of hypertension may be at increased risk for the development of proteinuria when treated with Avastin. There is evidence suggesting that ...
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79
A Fatal Brain Stroke in Patient with Advanced Breast Cancer ...
https://www.wjon.org/index.php/wjon/article/view/265
... with bevacizumab who developed hypertension had similar clinical presentations and biologic features, leading us to propose a unique mechanism for the ...
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https://www.wjon.org/index.php/wjon/article/view/265
... with bevacizumab who developed hypertension had similar clinical presentations and biologic features, leading us to propose a unique mechanism for the ...
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80
Sunitinib and Hypertension - GIST Support International
https://www.gistsupport.org/ask-the-professional/sunitinib-and-hypertension/
Many patients taking sunitinib (Sutent ®) experience hypertension (high blood ... It is seen with bevacizumab (Avastin ®), sorafenib (Nexavar ®) and ...
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https://www.gistsupport.org/ask-the-professional/sunitinib-and-hypertension/
Many patients taking sunitinib (Sutent ®) experience hypertension (high blood ... It is seen with bevacizumab (Avastin ®), sorafenib (Nexavar ®) and ...
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81
incidence and risk of hypertension with bevacizumab in non ...
https://www.scienceopen.com/document_file/0e992884-9f2d-44ac-a757-c5d93934e6c5/PubMedCentral/0e992884-9f2d-44ac-a757-c5d93934e6c5.pdf
on the occurrence of hypertension in patients receiving bevacizumab treatment may offer additional insights into the underlying mechanisms, risk factors, ...
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https://www.scienceopen.com/document_file/0e992884-9f2d-44ac-a757-c5d93934e6c5/PubMedCentral/0e992884-9f2d-44ac-a757-c5d93934e6c5.pdf
on the occurrence of hypertension in patients receiving bevacizumab treatment may offer additional insights into the underlying mechanisms, risk factors, ...
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82
Bevacizumab Article - StatPearls
https://www.statpearls.com/ArticleLibrary/viewarticle/18246
Summarize the mechanism of action of bevacizumab. ... Severe hypertension: Hypertension occurs as anti-VEGF therapy causes enhanced ...
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https://www.statpearls.com/ArticleLibrary/viewarticle/18246
Summarize the mechanism of action of bevacizumab. ... Severe hypertension: Hypertension occurs as anti-VEGF therapy causes enhanced ...
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83
Cancer therapy and cardiovascular risk: focus on bevacizumab
https://www.tandfonline.com/doi/pdf/10.2147/CMAR.S77400
clinical spectrum, risk factors, and responsible mechanisms. Keywords: bevacizumab, cardiovascular toxicity, hypertension. Introduction.
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https://www.tandfonline.com/doi/pdf/10.2147/CMAR.S77400
clinical spectrum, risk factors, and responsible mechanisms. Keywords: bevacizumab, cardiovascular toxicity, hypertension. Introduction.
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84
Role of renin-angiotensin system antagonists in the ...
https://journals.physiology.org/doi/10.1152/ajpheart.00344.2018
In the evolving field of cardio-oncology, bevacizumab and sunitinib ... an increased understanding of the molecular mechanisms of cancer has ...
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https://journals.physiology.org/doi/10.1152/ajpheart.00344.2018
In the evolving field of cardio-oncology, bevacizumab and sunitinib ... an increased understanding of the molecular mechanisms of cancer has ...
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85
bevacizumab [TUSOM | Pharmwiki] - TMedWeb
https://tmedweb.tulane.edu/pharmwiki/doku.php/bevacizumab
Bevacizumab · Trade Name: Avastin ® · Drug Class: Recombinant Humanized Monoclonal Antibody, Anticancer Drug · Mechanism of Action: Binds to VEGF-A ...
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https://tmedweb.tulane.edu/pharmwiki/doku.php/bevacizumab
Bevacizumab · Trade Name: Avastin ® · Drug Class: Recombinant Humanized Monoclonal Antibody, Anticancer Drug · Mechanism of Action: Binds to VEGF-A ...
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86
Avastin and Malignant Gliomas - Page 46 - Google Books Result
https://books.google.com/books?id=QORUTtb3pk4C&pg=PA46&lpg=PA46&dq=avastin+hypertension+mechanism&source=bl&ots=TaODs6zkIi&sig=ACfU3U2hXLXLvi3cZrIC7alOkRUWfrUUcw&hl=en&sa=X&ved=2ahUKEwj2m8nNy-D7AhWDonIEHQrYAQYQ6AF6BQjSAhAD
The mechanism of elevated blood pressure in patients treated with bevacizumab is likely multifactorial. One of the leading theories is the inhibition of ...
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https://books.google.com/books?id=QORUTtb3pk4C&pg=PA46&lpg=PA46&dq=avastin+hypertension+mechanism&source=bl&ots=TaODs6zkIi&sig=ACfU3U2hXLXLvi3cZrIC7alOkRUWfrUUcw&hl=en&sa=X&ved=2ahUKEwj2m8nNy-D7AhWDonIEHQrYAQYQ6AF6BQjSAhAD
The mechanism of elevated blood pressure in patients treated with bevacizumab is likely multifactorial. One of the leading theories is the inhibition of ...
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87
Principles of Cancer Biotherapy - Page 356 - Google Books Result
https://books.google.com/books?id=emGC_fRJH_IC&pg=PA356&lpg=PA356&dq=avastin+hypertension+mechanism&source=bl&ots=RsXt8kdeF8&sig=ACfU3U1oEEti9cjcjodmZ3Q1dKmS7nIDGQ&hl=en&sa=X&ved=2ahUKEwj2m8nNy-D7AhWDonIEHQrYAQYQ6AF6BQjUAhAD
Bevacizumab probably promotes anti-tumor effects by a number of mechanisms. The original concept for bevacizumab activity was that it would decrease tumor ...
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https://books.google.com/books?id=emGC_fRJH_IC&pg=PA356&lpg=PA356&dq=avastin+hypertension+mechanism&source=bl&ots=RsXt8kdeF8&sig=ACfU3U1oEEti9cjcjodmZ3Q1dKmS7nIDGQ&hl=en&sa=X&ved=2ahUKEwj2m8nNy-D7AhWDonIEHQrYAQYQ6AF6BQjUAhAD
Bevacizumab probably promotes anti-tumor effects by a number of mechanisms. The original concept for bevacizumab activity was that it would decrease tumor ...
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88
Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals
https://books.google.com/books?id=cYBGAAAAQBAJ&pg=PA524&lpg=PA524&dq=avastin+hypertension+mechanism&source=bl&ots=CfgMoMsW2-&sig=ACfU3U1kD8y_Rpo-pbEqQuq759C85EWg3Q&hl=en&sa=X&ved=2ahUKEwj2m8nNy-D7AhWDonIEHQrYAQYQ6AF6BQjWAhAD
Indeed, as far as hepatitis C treatment is concerned, dialysis patients often ... hypertension of 11% in patients receiving bevacizumab and chemotherapy as ...
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https://books.google.com/books?id=cYBGAAAAQBAJ&pg=PA524&lpg=PA524&dq=avastin+hypertension+mechanism&source=bl&ots=CfgMoMsW2-&sig=ACfU3U1kD8y_Rpo-pbEqQuq759C85EWg3Q&hl=en&sa=X&ved=2ahUKEwj2m8nNy-D7AhWDonIEHQrYAQYQ6AF6BQjWAhAD
Indeed, as far as hepatitis C treatment is concerned, dialysis patients often ... hypertension of 11% in patients receiving bevacizumab and chemotherapy as ...
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89
Perry's The Chemotherapy Source Book
https://books.google.com/books?id=3WBxG_vFp4IC&pg=PA665&lpg=PA665&dq=avastin+hypertension+mechanism&source=bl&ots=d9_HAdgI-s&sig=ACfU3U2zZD34ZPQrA4KWchanQdiUvNRGSQ&hl=en&sa=X&ved=2ahUKEwj2m8nNy-D7AhWDonIEHQrYAQYQ6AF6BQjTAhAD
Mechanism of action: Bevacizumab binds to all human forms of VEGF, preventing it from ... with proteinuria (Suspend Avastin administration for 2 g of ...
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https://books.google.com/books?id=3WBxG_vFp4IC&pg=PA665&lpg=PA665&dq=avastin+hypertension+mechanism&source=bl&ots=d9_HAdgI-s&sig=ACfU3U2zZD34ZPQrA4KWchanQdiUvNRGSQ&hl=en&sa=X&ved=2ahUKEwj2m8nNy-D7AhWDonIEHQrYAQYQ6AF6BQjTAhAD
Mechanism of action: Bevacizumab binds to all human forms of VEGF, preventing it from ... with proteinuria (Suspend Avastin administration for 2 g of ...
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