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1 Pathogenic roles of CXCL10 signaling through CXCR3 and ...
https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-017-1353-6
Arthritic Cxcl10 –/– and Cxcr3 –/– mice showed milder bone destruction, serum cytokines, and cell infiltration into synovium. These results ...
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2 CXCR3 and CCR5 ligands in rheumatoid arthritis ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/11141325/
The pathogenesis of rheumatoid arthritis (RA) may be mediated by Th1-type T cells. Since chemokine receptors CXCR3 and CCR5 are preferentially expressed on ...
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3 Chemokine receptor CXCR3 agonist prevents human ... - PNAS
https://www.pnas.org/doi/10.1073/pnas.1118104109
Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation.
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4 Blockade of Chemokine Receptor CXCR3 Inhibits T Cell ...
https://www.jimmunol.org/content/179/12/8463
These findings provide direct evidence that CXCR3 mediates T cell recruitment from the blood to inflamed joints in arthritis and, hence, has a major role in ...
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5 CXCR3 and CCR5 Ligands in Rheumatoid Arthritis Synovium
https://www.sciencedirect.com/science/article/pii/S152166160094957X
The pathogenesis of rheumatoid arthritis (RA) may be mediated by Th1-type T cells. Since chemokine receptors CXCR3 and CCR5 are preferentially expressed on ...
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6 TLR ligands and cytokines induce CXCR3 ligands in ... - Nature
https://www.nature.com/articles/3700453
Thus, CXCL9 is an important chemokine in autoimmune arthritis. ... The production of CXCR2 and CXCR3 ligands by endothelial cells upon ...
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7 THU0019 Intracellular expression of cxcr3 on rheumatoid ...
https://ard.bmj.com/content/60/Suppl_1/A211.1
Background Inflammatory cell infiltration and synovial activation are important processes in rheumatoid arthritis. Chemotactic gradients of various ...
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8 The production of CXCR3-agonistic ... - Springer Link
https://link.springer.com/article/10.1007/s00296-004-0449-x
The inflamed synovial tissue of rheumatoid arthritis (RA) is characterized by an infiltration with Th1 cells that predominantly express the ...
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9 expression of chemokine receptor CXCR3: relevance to disease ...
https://academic.oup.com/mr/article-abstract/13/2/114/6313756
In this study, we analyzed the expression of CXCR3 on peripheral blood T lymphocytes of patients with rheumatoid arthritis (RA) by FACS analysis using ...
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10 The expression of chemokine receptor CXCR3: relevance to ...
https://www.tandfonline.com/doi/abs/10.3109/s10165-002-0209-2
In this study, we analyzed the expression of CXCR3 on peripheral blood T lymphocytes of patients with rheumatoid arthritis (RA) by FACS analysis using ...
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11 Evaluating the Role of CXCR3 in Pain Modulation
https://www.dovepress.com/evaluating-the-role-of-cxcr3-in-pain-modulation-a-literature-review-peer-reviewed-fulltext-article-JPR
Hence, neutrophils, NK cells and CXCR3/CXL10 axis appear to be involved in the induction and progression of osteoarthritis. Therefore, CXCL10- ...
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12 Medline ® Abstract for Reference 117 of 'Juvenile idiopathic arthritis ...
https://www.uptodate.com/contents/juvenile-idiopathic-arthritis-epidemiology-and-immunopathogenesis/abstract/117
117: PubMed |; TI: Coexpression of chemokine receptors CCR5, CXCR3, and CCR4 and ligands for P- and E-selectin on T lymphocytes of patients with juvenile ...
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13 The production of CXCR3-agonistic chemokines by ... - Read by QxMD
https://read.qxmd.com/read/15004722/the-production-of-cxcr3-agonistic-chemokines-by-synovial-fibroblasts-from-patients-with-rheumatoid-arthritis
The inflamed synovial tissue of rheumatoid arthritis (RA) is characterized by an infiltration with Th1 cells that predominantly express the chemokine ...
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14 The expression of chemokine receptor CXCR3: Relavance to ...
https://tus.elsevierpure.com/en/publications/the-expression-of-chemokine-receptor-cxcr3-relavance-to-disease-a
The expression of chemokine receptor CXCR3: Relavance to disease activity of rheumatoid arthritis. Yumi Motoki, Kenji Tani, Teruki Shimizu, Hiroyuki Tamiya, ...
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15 CXCR3 + CCR5 + T cells and autoimmune diseases: guilty as ...
https://www.jci.org/articles/view/77837
In animal models of inflammatory arthritis and the experimental autoimmune encephalomyelitis (EAE) model of MS, chemokine and receptor inhibitors ameliorate ...
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16 CXCL10 and Its Receptor CXCR3 Regulate Synovial ...
https://www.researchgate.net/publication/51542954_CXCL10_and_Its_Receptor_CXCR3_Regulate_Synovial_Fibroblast_Invasion_in_Rheumatoid_Arthritis
Request PDF | CXCL10 and Its Receptor CXCR3 Regulate Synovial Fibroblast Invasion in Rheumatoid Arthritis | CXCL10 is expressed in increased ...
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17 Targeting the Chemokine System in Rheumatoid Arthritis and ...
https://www.jmaj.jp/detail.php?id=10.31662%2Fjmaj.2020-0019
In addition, chemokine receptors control the recruitment of neutrophils (CXCR1 and CXCR2), T helper type 1 (TH1) cell (CXCR3), lymphocyte (CXCR4) ...
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18 Chemokine receptor CXCR3 agonist prevents human T-cell ...
https://eprints.ncl.ac.uk/185216
The recruitment of T lymphocytes during diseases such as rheumatoid arthritis is regulated by stimulation of the chemokine receptors expressed ...
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19 Chemokine receptor CXCR3 agonist prevents human T ... - jstor
https://www.jstor.org/stable/41585538
Chemokine receptor CXCR3 agonist prevents human. T-cell migration in a humanized model of arthritic inflammation. Graeme O'Boyle3,1, Christopher R. J. Fox8, ...
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20 PRIME PubMed | CXCR3 and CCR5 ligands in rheumatoid arthritis ...
https://neuro.unboundmedicine.com/medline/citation/11141325/CXCR3_and_CCR5_ligands_in_rheumatoid_arthritis_synovium_
The pathogenesis of rheumatoid arthritis (RA) may be mediated by Th1-type T cells. Since chemokine receptors CXCR3 and CCR5 are preferentially expressed on ...
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21 Efficacy of potential rheumatoid arthritis therapy demonstrated ...
https://www.jax.org/news-and-insights/2012/april/efficacy-of-potential-rheumatoid-arthritis-therapy-demonstrated-in-humanize
PS372424, a CXCR3 agonist, shows anti-inflammatory activity both in vitro and in vivo in a humanized NSG mouse model of rheumatoid ...
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22 TNF-α and IL-6 Induced Upregulation of CCR5 and CXCR3 ...
https://acrabstracts.org/abstract/tnf-%CE%B1-and-il-6-induced-upregulation-of-ccr5-and-cxcr3-participate-in-v%CE%B42-chemotaxis-in-ra/
Keywords: inflammatory cytokines and rheumatoid arthritis (RA) ... The chemokine receptor CCR5 and CXCR3 expressed on Vδ2T cells in RA were ...
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23 Evolution, Expression and Functional Analysis of CXCR3 in ...
https://www.frontiersin.org/articles/10.3389/fcell.2022.882017/full
CXC chemokine receptor 3 (CXCR3) is a transmembrane G ... rheumatoid arthritis also showed increased CXCR3 expression (Nanki et al., 2009).
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24 Intermediate monocytes correlate with CXCR3+ Th17 cells but ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0249205
Intermediate monocytes correlate with CXCR3+ Th17 cells but not with bone characteristics in untreated early rheumatoid arthritis.
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25 CCL25, CXCL10 and XCL1 recrui - Osteoarthritis and Cartilage
https://www.oarsijournal.com/article/S1063-4584(10)00273-6/pdf
receptor CXCR3 showing the highest expression level. Conclusion: These results suggest that SF contains chemokines that may contribute to ...
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26 Pathogenic roles of CXCL10 signaling through CXCR3 and ...
https://s-space.snu.ac.kr/handle/10371/138313
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by uncontrolled joint inflammation and destruction of bone and cartilage. We previously ...
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27 Biased agonists of the chemokine receptor CXCR3 ... - Science
https://www.science.org/doi/10.1126/scisignal.aaq1075
The chemokine receptor CXCR3 plays a central role in inflammation by mediating effector/memory T cell migration in various diseases; however, ...
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28 CXCR3 Antagonist NBI-74330 Attenuates Atherosclerotic ...
https://www.ahajournals.org/doi/abs/10.1161/ATVBAHA.107.147827
Objective— The chemokine receptor CXCR3 is implicated in migration of ... B cells from patients with rheumatoid arthritis and systemic lupus erythematosus.
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29 Citrullination of CXCL10 and CXCL11 by peptidylarginine ...
https://ashpublications.org/blood/article-abstract/112/7/2648/24718/Citrullination-of-CXCL10-and-CXCL11-by
PAD was also able to convert CXCL11, causing an impairment of CXCR3 signaling and ... and citrullinated protein in synovial tissue of rheumatoid arthritis.
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30 ChemiBrite™ CXCR3 Chemokine Receptor Stable Cell Line -
https://www.discoverx.com/Products/Cell-Line/Stable-Cell-Line/HTS003L
... in inflamed tissues in rheumatoid arthritis and multiple sclerosis (Balashoy et al., 1999; Qin et al., 1998). In vivo, neutralization of CXCR3 inhibits ...
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31 T cells and chemokines in rheumatoid arthritis - GUPEA
https://gupea.ub.gu.se/handle/2077/68317
Baseline chemokine levels did not predict remission in eRA. TPh, Th1 and CXCR3+Th2 were the most abundant CD4+ T cell subsets in RA synovial ...
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32 Chemokine Receptor CXCR3 Mediates T Cell Recruitment ...
https://jasn.asnjournals.org/content/18/7/2071
The chemokine receptor CXCR3 is highly expressed on Th1 polarized T cells and has been ... glomerulonephritis, rheumatoid arthritis, and multiple sclerosis.
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33 its relation to disease activity and joint destruction - e-Marefa
https://search.emarefa.net/detail/BIM-381114
Aim of the work The aim of this study was to investigate the role of CXCR3 in rheumatoid arthritis (RA) and its relation to disease activity, synovitis, ...
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34 Desigining small molecule CXCR3 ACCEPTED - Spiral
https://spiral.imperial.ac.uk/bitstream/10044/1/43512/2/Desigining%20small%20molecule%20CXCR3%20ACCEPTED.pdf
The chemokine receptor CXCR3 is expressed by several different leukocytes, ... its ligands implicated in rheumatoid arthritis (RA) [3], multiple sclerosis ...
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35 CXCL10/CXCR3 signaling contributes to an inflammatory ...
https://elifesciences.org/articles/60646
Blockage of CXCL10/CXCR3 signaling between murine pancreatic ... through CXCR3 and TLR4 in macrophages and T cells: relevance for arthritis.
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36 Human Gene CXCR3 (ENST00000373693.4) from ...
https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CXCR3
Description: Homo sapiens C-X-C motif chemokine receptor 3 (CXCR3), ... extrinsic allergic alveolitis (6), septic arthritis (6), sarcoidosis 1 (6), ...
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37 Chemokine and chemokine receptor blockade in arthritis, a ...
https://www.njmonline.nl/getpdf.php?id=1093
Rheumatoid arthritis, chemokines, chemokine receptors, targeting. introdUCtion ... chemokines described above.4,5,83 CXCR3 may be the most.
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38 CXCR3 mediates chondrocyte injury through regulating nitric ...
https://www.europeanreview.org/wp/wp-content/uploads/2454-2460.pdf
in osteoarthritis patients (2.66 ± 0.25 vs. 1.00 ± 0.05, p<0.05). CXCR3 siRNA significant- ly reduced nitrate level in chondrocytes induced by IL-β ...
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39 Chemokines in arthritis: key molecules in pathogenesis and ...
https://www.openaccessjournals.com/articles/chemokines-in-arthritis-key-molecules-in-pathogenesis-and-potential-therapeutic-targets.pdf
Chemokines in arthritis: key molecules in ... Rheumatoid arthritis (RA) is the most common ... CXCR3 (CXCL9, CXCL10 receptor) and CCR5.
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40 Exploring the cxcr3 chemokine receptor with small-molecule ...
https://research.vu.nl/en/publications/exploring-the-cxcr3-chemokine-receptor-with-small-molecule-antago
... inflammatory bowel disease (IBD), rheumatoid arthritis, multiple sclerosis, and atherosclerosis, CXCR3 and/or its ligands are found to be overexpressed, ...
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41 C-X-C Chemokine Receptor-3 as a Diagnostic Biomarker in ...
https://jampr.journals.ekb.eg/article_157454.html
CXCR3 is a seven-transmembrane G-protein-coupled chemokine receptor that has been ... as a Diagnostic Biomarker in Patients with Rheumatoid Arthritis.
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42 Small Molecule CXCR3 Antagonists - ACS Publications
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5b01337
The chemokine receptor CXCR3 was identified in 1996, and nearly 20 ... CXCR3 antagonist AMG487 suppresses rheumatoid arthritis pathogenesis ...
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43 Chemokine receptor CXCR3 agonist prevents ... - Sigma-Aldrich
https://www.sigmaaldrich.com/BR/en/tech-docs/paper/1258876
Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. by Graeme O'Boyle, Christopher R J Fox, ...
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44 Deficiency of CXCR2, but not other chemokine receptors ...
https://cbdm.hms.harvard.edu/assets/Publications/2010/JacobsAR.pdf
CCR2, CXCR2, or CXCR3 (2,11–14). Antigen-induced arthritis was dampened by blockade of CXCR2 or genetic deficiency of CCR7 or CXCR5 (15,16). These.
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45 Effect of Low Level Laser Irradiation on CXCR3 Gene ...
https://www.jstage.jst.go.jp/article/jhtb/19/3/19_3_141/_pdf
Abstract: Rheumatoid arthritis (RA) is characterized by the infiltration of leukocytes into the synovial tissue and synovial fluid of joints, ...
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46 Pathogenic roles of CXCL10 signaling through ... - ProQuest
https://search.proquest.com/openview/0017982aaeec1d54995865689ff91458/1?pq-origsite=gscholar&cbl=42876
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by uncontrolled joint inflammation and destruction of bone and cartilage. We previously ...
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47 Elevation of the Chemokine Pair CXCL10/CXCR3 Initiates ...
https://www.karger.com/Article/Fulltext/493825
The effects of CXCL10/CXCR3 on glial interactions were explored by ... CXCR3 and TLR4 in macrophages and T cells: relevance for arthritis.
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48 Study on the mechanism for the production of CXCR3 ... - KAKEN
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570413/
Study on the mechanism for the production of CXCR3-agonisitic chemokines by synovial fibroblasts from patients with rheumatoid arthritis. Research Project.
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49 CXCR3 ligands in disease and therapy Katrien Van ... - CORE
https://core.ac.uk/download/pdf/34626404.pdf
Inflammatory arthritis. Over the years, CXCR3 ligands and their function in autoimmune diseases such as rheumatoid arthritis.
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50 Chemokine Receptors as Drug Targets
https://books.google.com/books?id=yfeR1msDzG4C&pg=PA303&lpg=PA303&dq=cxcr3+arthritis&source=bl&ots=O__-HHUJrD&sig=ACfU3U0koA1DJL1URo1x9bbe0pbV2AHQNA&hl=en&sa=X&ved=2ahUKEwie1quq2uD7AhXqhHIEHTNrDhkQ6AF6BQiEAhAD
Interestingly, three recent papers have shown that CXCR3-KO mice are ... In a mouse arthritis model, a CXCR3-antibody reduced T cell recruitment to inflamed ...
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51 CXC Chemokines—Advances in Research and Application: 2012 ...
https://books.google.com/books?id=qn7uSkGftiAC&pg=PA9&lpg=PA9&dq=cxcr3+arthritis&source=bl&ots=ABG565z__H&sig=ACfU3U2BJXszMm4NZIHEEr8HbkXSMjUPAA&hl=en&sa=X&ved=2ahUKEwie1quq2uD7AhXqhHIEHTNrDhkQ6AF6BQiCAhAD
CXCR3. Regulate. Synovial. Fibroblast Invasion in Rheumatoid Arthritis “CXCL10 ... from arthritic DA rats and from patients with rheumatoid arthritis (RA).
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52 Characterisation of the Chemokine Receptor CXCR3 and its ...
https://researchportal.bath.ac.uk/en/studentTheses/characterisation-of-the-chemokine-receptor-cxcr3-and-its-atypical
The chemokine receptor CXCR3 and its agonists CXCL9/Mig, CXCL10/IP-10 and ... including multiple sclerosis, rheumatoid arthritis, psoriasis and sarcoidosis.
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53 Researchers dicover novel targets for rheumatoid arthritis ...
https://www.drugtargetreview.com/news/76173/researchers-dicover-novel-targets-for-rheumatoid-arthritis-therapies/
The team also found these RA B cells expressed a protein called CXCR3 which Dr Floudas said “seems to be responsible for attracting [B cells] to ...
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54 Association of the CXCL9-CXCR3 and CXCL13-CXCR5 axes ...
https://research.rug.nl/files/175609252/Graver_J_Autoimm_2021.pdf
Boots,. E. Brouwer, Disturbed B cell homeostasis in newly diagnosed giant cell arteritis and polymyalgia rheumatica, Arthritis Rheum. 66 (2014) 1927–1938, https ...
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55 Pathogenic roles of CXCL10 signaling through CXCR3 ... - Gale
https://link.gale.com/apps/doc/A511292150/HRCA?u=googlescholar&sid=googleScholar&xid=b47ea363
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by uncontrolled joint inflammation and destruction of bone and cartilage.
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56 New potential target for rheumatoid arthritis - EurekAlert!
https://www.eurekalert.org/news-releases/521867
Newcastle University scientists, in work funded by Arthritis Research ... CXCR3 they are not directed to migrate towards rheumatoid sites.
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57 Rheumatoid arthritis and the alpha-chemokine IP-10 Review
https://www.clinicaterapeutica.it/download/370/fascicolo-6/7906/165-06-24_rassegna_di_domenicantonio_completo.pdf
Abstract. Interferon(IFN)-gamma-induced protein 10 (IP-10) and its recep- tor, CXCR3, appear to contribute to the pathogenesis of rheumatoid arthritis (RA).
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58 The Distinct Roles of CXCR3 Variants and Their Ligands in ...
https://www.mdpi.com/2073-4409/8/6/613/htm
The two chemokine receptor 3 variants CXCR3-A and CXCR3-B, together with ... with elevated levels of CXCR3 ligands in septic arthritis synovial fluids.
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59 CCR6(+) Th cell populations distinguish ACPA positive from ACPA ...
https://pure.eur.nl/en/publications/ccr6-th-cell-populations-distinguish-acpa-positive-from-acpa-nega
Introduction: Patients with rheumatoid arthritis (RA) can be separated into two major ... of Th cells expressing the chemokine receptors CCR6 and CXCR3.
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60 Juvenile Rheumatoid Arthritis: New Insights for the ...
https://books.google.com/books?id=rHTPp6zufBQC&pg=PA3&lpg=PA3&dq=cxcr3+arthritis&source=bl&ots=QXRJCxT11R&sig=ACfU3U2RUbwp6p0yiChQhlkt0nw2_0F0RA&hl=en&sa=X&ved=2ahUKEwie1quq2uD7AhXqhHIEHTNrDhkQ6AF6BQiDAhAD
Issekutz and colleagues published their study in Arthritis and Rheumatism (Coexpression of Chemokine Receptors CCR5, CXCR3, and CCR4 and Ligands for P- and ...
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61 Contemporary Challenges in Autoimmunity, Volume 1173
https://books.google.com/books?id=0jP8TlUNpMkC&pg=PA316&lpg=PA316&dq=cxcr3+arthritis&source=bl&ots=GPaTijDhep&sig=ACfU3U25aozDrlwHlHj00vm3gIzU3dPVvQ&hl=en&sa=X&ved=2ahUKEwie1quq2uD7AhXqhHIEHTNrDhkQ6AF6BQiFAhAD
expectations linked to the CXCR3 chemokine receptor, nor patients' hopes. ... CXCR3 in the synovial sublining regions of early rheumatoid arthritis in ...
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62 Goat anti-CXCR3 / GPR9 Antibody - Angio-Proteomie
https://www.angioproteomie.com/commerce/ccp17508-goat-anti-cxcr3---gpr9-antibody-dap-1119.htm
Catalogue NO: dAP-1119, Product Name: Goat anti-CXCR3 / GPR9 Antibody, ... expression in the synovium of children with juvenile idiopathic arthritis.
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63 Comparison of the Effects of Chemokine Receptors CXCR2 ...
https://mdpi-res.com/d_attachment/ijms/ijms-22-11074/article_deploy/ijms-22-11074.pdf?version=1634219746
chemokines and comprises ligands of CXCR2 (CXCL1-3) and CXCR3 (CXCL4 and CXCL9- ... joints of patients with rheumatoid arthritis [99].
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64 The Chemokine Receptors - Page 194 - Google Books Result
https://books.google.com/books?id=Zlk1BU1iQPkC&pg=PA194&lpg=PA194&dq=cxcr3+arthritis&source=bl&ots=L2TXnY2O5W&sig=ACfU3U0yWgKb-0S_9lP7JxwqfrRxwakAxA&hl=en&sa=X&ved=2ahUKEwie1quq2uD7AhXqhHIEHTNrDhkQ6AF6BQiHAhAD
Accumulation of plasma cells expressing CXCR3 in the synovial sublining regions of early rheumatoid arthritis in association with production of Mig/CXCL9 by ...
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65 Construction of a T cell receptor signaling range for ...
https://rupress.org/jem/article/220/2/e20220386/213728/Construction-of-a-T-cell-receptor-signaling-range?searchresult=1
SKG mice spontaneously developed autoimmune arthritis in microbially conventional ... IL-17A, and IL-4, and highly expressed CXCR3 and CCR6, ...
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66 Study suggests persistent immune activation and long COVID ...
https://www.news-medical.net/news/20221130/Study-suggests-persistent-immune-activation-and-long-COVID-correlate-independently-with-severe-COVID-19.aspx
The presence of high levels of CD4+ T cells expressing CXCR3 suggested lung-tissue damage. Increased levels of granzyme B expression in CD8+ ...
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67 The chemokine receptor CXCR3 promotes CD8 + T cell ...
https://www.biorxiv.org/content/10.1101/2022.02.14.480379v1
The neutralization of CXCR3 mitigated lung injury without affecting viral clearance. IFN-γ was dispensable to regulate the cytotoxic response of ...
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68 Intestinal permeability - Wikipedia
https://en.wikipedia.org/wiki/Intestinal_permeability
Intestinal permeability is a term describing the control of material passing from inside the ... One way in which intestinal permeability is modulated is via CXCR3 ...
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69 Mast cells crucial to causing osteoarthritis - Stanford Medicine
https://med.stanford.edu/news/all-news/2019/05/mast-cells-crucial-to-causing-osteoarthritis.html
Osteoarthritis, by far the most frequently occurring variety of arthritis, is characterized by cartilage breakdown and inflammation in joints, ...
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70 CXCR3 and CCR5 Ligands in Rheumatoid Arthritis Synovium ...
https://ur.booksc.eu/book/15692360/aa4565?switchLanguage=ur
CXCR3 and CCR5 Ligands in Rheumatoid Arthritis Synovium | Dhavalkumar D. Patel; Jason P. Zachariah; Leona P. Whichard | download | BookSC.
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71 The Great Oxymoron: Inflammatory Osteoarthritis
https://arapc.com/great-oxymoron-inflammatory-osteoarthritis/
Osteoarthritis typically is thought of as a degenerative arthritis in which the joint space is gradually lost with little or no associated ...
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72 Cytokine signalling in rheumatoid arthritis (G-CSF ... - YouTube
https://www.youtube.com/watch?v=yXC-tGlDAiM
WEHI Seminars
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73 New approach could bring closer a cure for a painful form of ...
https://www.ndorms.ox.ac.uk/news/new-approach-could-bring-closer-a-cure-for-a-painful-form-of-arthritis
AS is a painful and progressive form of inflammatory arthritis, affecting around 200,000 people in the UK. The disease causes inflammation ...
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