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1 NF-κB in Aging and Disease - PubMed
https://pubmed.ncbi.nlm.nih.gov/22396894/
The IKK/NF-κB signaling pathway has been proposed to be one of the key mediators of aging. It is activated by genotoxic, oxidative, and inflammatory stresses ...
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2 Role of NF-κB in Ageing and Age-Related Diseases - MDPI
https://www.mdpi.com/2073-4409/10/8/1906
NF-κB is the key transcription factor found on the axis of the ageing inflammatory network: it is activated by different factors, such as mitochondrial ...
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3 Systems approaches to investigate the role of NF-κB signaling ...
https://portlandpress.com/biochemj/article/479/2/161/230718/Systems-approaches-to-investigate-the-role-of-NF-B
NF-κB is linked not only to diseases such as cancer but also to the aging process [2]. Aging is an unavoidable time-dependent decline in physiological organ ...
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4 NF-κB in Innate Neuroprotection and Age-Related ... - Frontiers
https://www.frontiersin.org/articles/10.3389/fneur.2015.00098/full
NF-κB in innate neuroprotection and age-related neurodegenerative diseases · Introduction · RelA and c-Rel: Two Opposing Regulators of Neuronal Resilience to ...
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5 NF-kappa B in Aging and Disease | Request PDF
https://www.researchgate.net/publication/297555057_NF-kappa_B_in_Aging_and_Disease
The IKK/NF-kappa B signaling pathway has been proposed to be one of the key mediators of aging. It is activated by genotoxic, oxidative, and ...
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6 NF‐κB as the mediator of metformin's effect on ageing and ...
https://onlinelibrary.wiley.com/doi/10.1111/1440-1681.13073
The nuclear factor-kappa B (NF-kB) pathway is one of the key mediators of ageing and this pathway is activated by genotoxic, oxidative and ...
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7 The role of NF-kB signaling in Aging - Jeremy Tilstra - Grantome
https://grantome.com/grant/NIH/F30-AG032816-01A2
Thus I hypothesize that NF-KB activation due to the accumulation of cellular damage has a causal role in the aging process and age-associated diseases.
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8 Inhibition of IKKβ/NF-κB signaling facilitates tendinopathy ...
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(21)00329-2
We found that AuNC-siRNA prevented inflamm-aging-induced TSPC senescence and dysfunction in a degenerative RCT aged rat model. Together, these ...
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9 New NF-κB Targeting Drug Improves Healthspan in Mice
https://www.lifespan.io/news/new-nf-%CE%BAb-targeting-drug-improves-healthspan-in-mice/
NF-κB in aging and disease · NF-κB as a therapeutic target · Anti-aging benefits in vitro, in premature aging models, and in naturally aged mice.
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10 Diseases » NF-kB Transcription Factors | Boston University
https://www.bu.edu/nf-kb/physiological-mediators/diseases/
On this page are listed several diseases in which activation of NF-kB has been implicated. For general reviews on the role of NF-kB in disease, see Aradhya & ...
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11 Age-associated changes in basal NF-κB function in human ...
https://www.aging-us.com/article/100705/text
by A Bektas · 2014 · Cited by 42 —
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12 NF-κB in Aging and Disease. - ebsco
http://search.ebscohost.com/login.aspx?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=21525250&AN=69883026&h=Kv8y6AU15iiiVLHBQzWCk2BJiB1AFnidPlkiLi8zEZUW7xvGuRozu2j9hKiOsIvlTcDGJAyoFSSyXGlvLjZQ7Q%3D%3D&crl=c
NF-κB. Senescence. Abstract: Stochastic damage to cellular macromolecules and ... with numerous age-related degenerative diseases including Alzheimer's, ...
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13 IKKβ–NF-κB signaling in adult chondrocytes promotes the ...
https://www.science.org/doi/abs/10.1126/scisignal.abf3535
Proinflammatory signaling mediated by the transcription factor NF-κB is implicated in osteoarthritis (OA) induced by joint injury.
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14 SS31 Ameliorates age-related activation of NF-κB signaling in ...
https://www.oncotarget.com/article/14077/text/
Our data showed that aging could activate both NF-κB and Nrf2-ARE signaling pathways, which could be suppressed and activated by SS31 treatment ...
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15 Context-Dependent Regulation of Autophagy by IKK-NF-κB ...
https://www.hindawi.com/journals/ijcb/2012/849541/
Several studies have indicated that NF-κB signaling is enhanced both during aging and cellular senescence, inducing a proinflammatory phenotype.
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16 Pivotal role of NF-κB in cellular senescence of experimental ...
https://joe.bioscientifica.com/view/journals/joe/245/2/JOE-19-0506.xml
The balance between cell proliferation and senescence mechanisms, which is linked to NF-κB activation, finally defines the tumour growth. Having demonstrated ...
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17 Cohesin-mediated NF-κB signaling limits hematopoietic stem ...
https://rupress.org/jem/article/216/1/152/42448/Cohesin-mediated-NF-B-signaling-limits
During aging, an increase in NF-κB activation has been reported in HSCs (Chambers et al., 2007), but mechanisms and consequences of NF-κB activation on the ...
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18 NF-κB inhibition delays DNA damage–induced senescence ...
https://www.jci.org/articles/view/45785
XFE progeroid syndrome is a disease of accelerated aging caused by a defect in DNA repair. NF-κB, a transcription factor activated by cellular damage and ...
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19 NF-κB signaling in inflammation - Nature
https://www.nature.com/articles/sigtrans201723
Consequently, deregulated NF-κB activation contributes to the pathogenic processes of various inflammatory diseases. In this review, we will ...
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20 Epigenetic upregulation of FKBP5 by aging and stress ... - PNAS
https://www.pnas.org/doi/10.1073/pnas.1816847116
Accordingly, experiments in immune cells showed that higher FKBP5 promotes inflammation by strengthening the interactions of NF-κB regulatory ...
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21 Canonical NF-κB signaling maintains corneal epithelial ... - eLife
https://elifesciences.org/articles/67315
Our findings indicate that NF-κB signaling plays an anti-aging role in mouse cornea. On the other hand, NF-κB activation can increase the ...
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22 Inhibition of NF-κB improves the stress resistance and ... - PLOS
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179270
Furthermore, in a mouse model of accelerated aging, blockade of NF-κB reduced oxidative stress-induced DNA damage [14]. Based on our data, NF-κB ...
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23 Methods to Quantify the NF-κB Pathway During Senescence
https://experiments.springernature.com/articles/10.1007/978-1-4939-8931-7_18
NF-κB activity goes up with age in multiple tissues. The two subunits RelA/p65 and p50 have been implicated in senescence and aging with genetic deletion of p65 ...
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24 Role of Nuclear Factor Kappa B (NF-κB) Signalling in ...
http://www.eurekaselect.com/179127/article
The recent research implicated the intensive role of nuclear factor kappa B (NF-κB) in diseases like autoimmune disorder, inflammatory, cardiovascular and ...
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25 The Nuclear Factor NF-κB Pathway in Inflammation
https://cshperspectives.cshlp.org/content/1/6/a001651
The nuclear factor NF-κB pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of ...
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26 NF-κB signaling in skeletal muscle: prospects for intervention ...
https://link.springer.com/article/10.1007/s00109-008-0308-4
In one study, NF-κB protein concentrations were found to be fourfold higher in elderly human muscles compared to those of young people [76].
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27 Role of NF-κB in Ageing and Age-Related Diseases - ProQuest
https://search.proquest.com/openview/ca46bebf02a6b1a6f5aa246886369f19/1?pq-origsite=gscholar&cbl=2032536
Chronic inflammation is a major mechanism that promotes the biological ageing process and comorbidity, with the transcription factor NF-κB (nuclear factor kappa ...
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28 The effects of aging on muscle loss and tissue-specific levels ...
https://www.scirp.org/journal/paperinformation.aspx?paperid=27862
The transcription factor, Nuclear Factor Kappa-B (NF-κB), is associated with both catabolic and anabolic pathways of muscle metabolism and may be involved in ...
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29 Augmented Expression of Inducible NO Synthase in Vascular ...
https://www.ahajournals.org/doi/10.1161/01.ATV.19.12.2854
Our data demonstrate an intense transactivation of NF-κB in old SMCs on tumor necrosis factor-α stimulation but only a weak one in newborn SMCs. The difference ...
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30 Klotho Prevents NFκB Translocation and Protects Endothelial ...
https://academic.oup.com/biomedgerontology/article/70/10/1198/2605456
Abstract. In patients with renal disease, uremia raises oxidative stress and senescence in endothelial cells, which can lead to endothelial ...
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31 Paper - ALZFORUM | NETWORKING FOR A CURE
https://www.alzforum.org/papers/nf-kb-aging-and-disease
Tilstra JS, Clauson CL, Niedernhofer LJ, Robbins PD. NF-κB in Aging and Disease. Aging Dis. 2011 Dec;2(6):449-65. PubMed. Recommends.
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32 Fight Inflammation by Inhibiting NF-KB - Life Extension
https://www.lifeextension.com/magazine/2019/7/fighting-inflammation-by-inhibiting-nf-kb
Inhibiting a cellular protein complex called nuclear factor kappa B (NF-kB) helps prevent inflammation-driven aging as well as insulin resistance and ...
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33 Redox Regulation of NF-κB Activation - Mary Ann Liebert, Inc.
https://www.liebertpub.com/doi/10.1089/ars.2005.7.395
NF-κB plays a central role in immune responses and inflammation, through regulation of the gene expression of a large number of cytokines and other immune ...
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34 Role of NF-kB in Alzheimer's Disease | Encyclopedia MDPI
https://encyclopedia.pub/entry/26367
In the AD brain, Toll-like Receptors (TLRs) are overexpressed on microglia and neurons. TLRs mainly activate the canonical NF-κB signaling ...
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35 NF-κB - Wikipedia
https://en.wikipedia.org/wiki/NF-%CE%BAB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a protein complex that controls transcription of DNA, cytokine production and cell ...
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36 NF-kB: THE PATHWAY OF INFLAMMATION. Good cop, bad cop
https://stcell.com/blogs/193/nf-kb-the-pathway
NF-κB then acts to promote aging related changes by contributing to cellular senescence, SASP, apoptotic signals and inflammatory responses. The ...
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37 NF-kB and Inflammation - Finding the Longevity Balance
https://youthandearth.com/blogs/blog/nfkb-inflammation-longevity
The NF-kB longevity pathway regulates the inflammatory response in our bodies as well as many other critical processes. But when levels become out of ...
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38 NF-κB and Inflammation - Sigma-Aldrich
https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/protein-biology/protein-expression/nf-b-and-inflammation
Altered regulation of NF-κB activity is observed in many genetically- linked diseases and chronic diseases of aging, including cancer. ... NF-κB activation has ...
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39 Icariin modulates the sirtuin/NF‑κB pathway and exerts anti ...
https://www.spandidos-publications.com/10.3892/mmr.2020.11458
Taken together, the results of the present study suggest that the anti‑aging molecular mechanisms of ICA may be associated with the regulation ...
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40 Anti-Inflamm-Aging Effects of Long-Term Caloric Restriction ...
https://www.karger.com/Article/FullText/430248
Conclusions: The inflammatory response might be alleviated by SIGIRR via blockade of the TLR4/NF-κB signaling pathway. Therefore, CR can ...
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41 Epigenetic derepression of FKBP5 by aging and stress ...
https://www.biorxiv.org/content/10.1101/484709v1
These findings suggest that FKBP5-NF-κB signaling mediates inflammation associated with aging and stress, potentially contributing to ...
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42 The Role of APOE and NF-κB in Alzheimer's Disease - MDPI
https://mdpi-res.com/d_attachment/immuno/immuno-01-00027/article_deploy/immuno-01-00027.pdf?version=1635405875
Cognitively normal APOE4 carriers received PiB PET imaging that indicated fibrillar aggregates of Aβ at approximately 56 years of age, compared ...
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43 Calorie restriction-induced SIRT6 activation delays aging by ...
https://www.tandfonline.com/doi/pdf/10.1080/15384101.2016.1152427
aging; calorie restriction; inflammation; kidney; NF-kB; p16; SIRT6. Introduction. Aging is the major risk factor for multiple diseases, ...
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44 NFκB Promotes Inflammation, Coagulation, and Fibrosis in the ...
https://jasn.asnjournals.org/content/21/4/587
Under the filter “anatomy,” high Z scores indicated that gene expression changes with age occurred in epithelial and endothelial cells and ...
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45 Exploration of a novel NF-kB-Nucleolar stress response ...
https://www.ed.ac.uk/mrc-human-genetics-unit/graduate-research-and-training/eastbio-phd-projects/dr-lesley-stark-dr-tamir-chandra-project
Exploration of a novel NF-kB-Nucleolar stress response pathway that has relevance to ... Given the role of SASP in aging and disease, ...
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46 What is NF-κB pathway? - MBInfo
https://www.mechanobio.info/what-is-mechanosignaling/signaling-pathways/what-is-the-nf-%CE%BAb-pathway/
NF-κB (nuclear factor kappa light chain enhancer of activated B cells) is a family of highly conserved transcription factors that regulate many important ...
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47 Growing old with NF-kB - Scientific American Blog Network
https://blogs.scientificamerican.com/scicurious-brain/growing-old-with-nf-kb/
NF-kB (which stands for nuclear factor kappa-light-chain-enhancer of activated B cells, which is why we use NF-kB) is a protein complex that has ...
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48 Inflammation and endothelial dysfunction during aging: role of ...
https://journals.physiology.org/doi/10.1152/japplphysiol.90470.2008
Our study demonstrates that oxidative stress-mediated NF-κB activation increases monocyte adhesiveness to endothelial cells of aged arteries via induction of ...
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49 Role of NF-κB in Ageing and Age-Related Diseases: Lessons from ...
https://www.researcher-app.com/paper/8309294
Chronic inflammation is a major mechanism that promotes the biological ageing process and comorbidity, with the transcription factor NF-κB (nuclear factor kappa ...
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50 Roles of NF-κB in Cancer and Their Therapeutic Approaches
https://books.google.com/books?id=E-6RDwAAQBAJ&pg=PA297&lpg=PA297&dq=nf+%CE%BAb+in+aging+and+disease&source=bl&ots=OoTKygoVaV&sig=ACfU3U1GFfU2SpT84lVbUrrJj4ciT5HdQw&hl=en&sa=X&ved=2ahUKEwif2sSx6-D7AhVZCKYKHT5ECWkQ6AF6BQj4ARAD
Inflamm. Res. 1998, 47,440–445. [CrossRef][PubMed] 7. Tilstra, J.S.; Clauson, C.L.; Niedernhofer, L.J.; Robbins, P.D. NF-κB in aging and disease. Aging Dis.
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51 10 Proven Health Benefits of Turmeric and Curcumin
https://www.healthline.com/nutrition/top-10-evidence-based-health-benefits-of-turmeric
By doing this, it may be effective in delaying or even reversing many brain diseases and age-related decreases in brain function. Still, since these studies ...
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52 KEGG PATHWAY Database
https://www.genome.jp/kegg/pathway.html
1. Metabolism · 2. Genetic Information Processing · 3. Environmental Information Processing · 4. Cellular Processes · 5. Organismal Systems · 6. Human Diseases · 7.
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53 NF-κB Pathway | Cell Survival Pathway - YouTube
https://www.youtube.com/watch?v=8HWVhdSRvng
Hussain Biology
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54 #02 - Rhonda Patrick, Ph.D.: the performance and longevity ...
https://peterattiamd.com/rhondapatrick/
Can saunas lower the risk of heart disease, dementia, and all-cause ... She has done extensive research on aging, cancer, and nutrition.
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55 bims-mitmed 2022-12-04 papers - Biomed News
http://biomed.news/bims-mitmed/2022-12-04
Mitochondrial copper in human genetic disorders. ... increased senescence-associated β-galactosidase activity, augmented NF-κB activity, ...
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56 TURMERIC - Uses, Side Effects, and More - WebMD
https://www.webmd.com/vitamins/ai/ingredientmono-662/turmeric
People commonly use turmeric for osteoarthritis. It is also used for hay fever, depression, high cholesterol, a type of liver disease, and itching, but there is ...
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57 Post-inflammatory hyperpigmentation in dark skin | CCID
https://www.dovepress.com/post-inflammatory-hyperpigmentation-in-dark-skin-molecular-mechanism-a-peer-reviewed-fulltext-article-CCID
Hyperpigmentation can affect any person, regardless of age and gender. ... nuclear factor kappa B (NF-κB) activity in the keratinocytes.
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58 Soumen Basak (@Systems_Immunol) / Twitter
https://twitter.com/systems_immunol?lang=en
The paper offers a wonderful tool to study NF-kB, without genetic silencing or ... Double knockin mice show NF-κB trajectories in immune signaling and aging.
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59 Download Free Adipose Derived Stem Cells Methods ... - Alessa
https://new.alessa.bg/reader/satu?e=Q6F6A7&FileName=Adipose%20Derived%20Stem%20Cells%20Methods%20And%20Protocols%20Methods%20In%20Molecular%20Biology
Theranostics NF-kappa B Chromatin Proteoform Identification ... could be expected to rise dramatically in the future owing to an aging.
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60 cysteine deficiency causes
https://casablu.cl/7dowczr/cysteine-deficiency-causes
Rasmussen JB, Glennow C. Reduction in days of illness after long-term treatment ... Sastre J, Pallardo FV, Vina J. Glutathione, oxidative stress and aging.
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61 Renal NF-κB activation impairs uric acid homeostasis ... - 科研通
https://www.ablesci.com/assist/detail?id=2yy75j
免疫系统 平衡 医学 生物 IκB激酶 内科学 内分泌学 促炎细胞因子 免疫学 癌症研究 肠道菌群 炎症 失调 NF-κB 浪费的 尿酸.
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62 The Proteasomal System in Aging and Disease
https://books.google.com/books?id=dp_9KV8GzvAC&pg=PA365&lpg=PA365&dq=nf+%CE%BAb+in+aging+and+disease&source=bl&ots=wygBUno3lU&sig=ACfU3U3QYo1dWKOs57y-XT0Q0VI4dIH6ZA&hl=en&sa=X&ved=2ahUKEwif2sSx6-D7AhVZCKYKHT5ECWkQ6AF6BQj3ARAD
The UPP activity is also required to regulate the noncanonical pathway of NF-kB. The MAP 3 kinase MAP3K14, also known as NF-kB-inducing kinase (NIK), ...
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63 triose phosphate isomerase function - 智研有限公司
https://zhiyan.com.tw/frtsaw/triose-phosphate-isomerase-function
Also, NF-kB controls the expression of almost 100 proinflammatory genes encoding ... Fructose and glucose differentially affect aging and carbonyl/oxidative ...
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64 Aging Mechanisms II: Longevity, Metabolism, and Brain Aging
https://books.google.com/books?id=lWNtEAAAQBAJ&pg=PA180&lpg=PA180&dq=nf+%CE%BAb+in+aging+and+disease&source=bl&ots=A71lXXHZwV&sig=ACfU3U2e4wZoSTmNeT8oNRqnbch9zviMcA&hl=en&sa=X&ved=2ahUKEwif2sSx6-D7AhVZCKYKHT5ECWkQ6AF6BQj1ARAD
... particularly the nuclear factor-kappa B (NF-κB) pathway, in the development of aging-related metabolic disorders (Candore et al. 2010; Mendes et al.
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65 Inflammation, Advancing Age and Nutrition: Research and ...
https://books.google.com/books?id=fTkTAAAAQBAJ&pg=PA7&lpg=PA7&dq=nf+%CE%BAb+in+aging+and+disease&source=bl&ots=jPL1dixsoq&sig=ACfU3U1i2PySvkU34d9cXXQdYCqOoOtEOQ&hl=en&sa=X&ved=2ahUKEwif2sSx6-D7AhVZCKYKHT5ECWkQ6AF6BQjwARAD
Components of the NF-κB pathway are the targets of several post-translation ... biomarkers of both biological aging and disease onset and progression [53].
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66 Dual Role of Microglia in Health and Disease: Pushing the ...
https://books.google.com/books?id=rWtkCgAAQBAJ&pg=PA82&lpg=PA82&dq=nf+%CE%BAb+in+aging+and+disease&source=bl&ots=f_fD7DKe6p&sig=ACfU3U2qJBJ3sOxLrMAXCfdCUfeLWAHbFw&hl=en&sa=X&ved=2ahUKEwif2sSx6-D7AhVZCKYKHT5ECWkQ6AF6BQiBAhAD
The morphological changes of in vitroaging microglia occurred in parallel with a decrease in the transactivation of NF-κB. It is well known that this ...
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67 Defining and Characterizing Respiratory Disease in an Aging ...
https://books.google.com/books?id=rtxmEAAAQBAJ&pg=PA81&lpg=PA81&dq=nf+%CE%BAb+in+aging+and+disease&source=bl&ots=Z9T_JxcXcG&sig=ACfU3U3OcUVNIsaLr_1GFdcU-Q6ZecO87g&hl=en&sa=X&ved=2ahUKEwif2sSx6-D7AhVZCKYKHT5ECWkQ6AF6BQjvARAD
lung collagen AGE-load increases with age and anti-correlates with enzymatic solubility ... This leads predominantly to sustained activation of NF-κB- and ...
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68 Autophagy: Cancer, Other Pathologies, Inflammation, ...
https://books.google.com/books?id=6ROKCgAAQBAJ&pg=PA344&lpg=PA344&dq=nf+%CE%BAb+in+aging+and+disease&source=bl&ots=GV3nxZC3rb&sig=ACfU3U1E4JWUWeYV1qRqIJPv18WUzeyP0g&hl=en&sa=X&ved=2ahUKEwif2sSx6-D7AhVZCKYKHT5ECWkQ6AF6BQj5ARAD
Volume 8- Human Diseases M. A. Hayat ... See Axonophagy Neuronal isoform of protein interaction, 83 NF-κB. See Nuclear factor-κB (NF-κB) NFE2-related factor ...
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69 Handbook of the Biology of Aging - Page 113 - Google Books Result
https://books.google.com/books?id=T9LUBQAAQBAJ&pg=PA113&lpg=PA113&dq=nf+%CE%BAb+in+aging+and+disease&source=bl&ots=cRuV_3X6gX&sig=ACfU3U0LiFrBELAm712qbBFIoLp1l4PkRQ&hl=en&sa=X&ved=2ahUKEwif2sSx6-D7AhVZCKYKHT5ECWkQ6AF6BQj0ARAD
SIRT6 binds to the NF-κB RELA/p65 subunit and interacts with the promoters of ... diseases such as Alzheimer's disease (AD), Huntington's disease (HD), ...
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70 Enfermedad Renal Crónica - Revistas Bolivianas
http://www.revistasbolivianas.ciencia.bo/scielo.php?pid=S2304-37682011000800009&script=sci_arttext&tlng=es
... Globales en Enfermedades Renales (Kidney Disease Improving Global Outcome-KDIGO), ... tubular nuclear kappa B (NF-kB) y la protetna activada 1 (AP-1), ...
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71 Biomarkers and Pathogenesis of Alpha-Synuclein in ...
https://books.google.com/books?id=1JdaEAAAQBAJ&pg=PA171&lpg=PA171&dq=nf+%CE%BAb+in+aging+and+disease&source=bl&ots=JeNtiR24r-&sig=ACfU3U1Pb6MPs_ck6btvewqJJgqsKrCHdA&hl=en&sa=X&ved=2ahUKEwif2sSx6-D7AhVZCKYKHT5ECWkQ6AF6BQj2ARAD
... Parkinson's disease (PD) and osteoporosis are both common aging diseases. ... U-test and Spearman's receptor activator of NF-κB (RANK) correlation.
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72 Increasing Longevity and Quality of Life Through Biohacking
https://krisgethin.libsyn.com/boundless-increasing-longevity-and-quality-of-life-through-biohacking
... Ben's top 10 biohacks, learn ways to increase the effectiveness of these techniques and discover new ways to hack performance and aging.
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