1 Alternative splicing of Wilms tumor suppressor 1 (Wt1) exon 4 ...
https://pubmed.ncbi.nlm.nih.gov/25014653/
Alternative splicing and genomic structure of the Wilms tumor gene WT1. ... The WT1 gene consists of 10 exons, encoding a complex pattern of mRNA species: ...
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2 WT1 interacts with the splicing factor ... - Genes & Development
http://genesdev.cshlp.org/content/12/20/3217.full
WT1 is alternatively spliced and isoforms that include three amino acids, KTS, show stronger interaction with U2AF65 in vitro and better colocalization with ...
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3 RNA Binding by the KTS Splice Variants of Wilms' Tumor ...
https://pubs.acs.org/doi/10.1021/acs.biochem.0c00602
WT1 has two major splice variants, where the Lys-Thr-Ser (KTS) tripeptide is inserted into the linker between the third and fourth zinc fingers.
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4 Alternative splicing and genomic structure of the ... - PNAS
https://www.pnas.org/doi/10.1073/pnas.88.21.9618
The chromosome 11p13 Wilms tumor susceptibility gene WT1 appears to play a crucial role in regulating the proliferation and differentiation of nephroblasts ...
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5 Disruption of WT1 gene expression and exon 5 splicing ...
https://aacrjournals.org/mct/article/3/11/1467/234179/Disruption-of-WT1-gene-expression-and-exon-5
WT1 is subject to alternative splicing involving exon 5 and three amino acids ... 4) and alternative splicing of WT1 mRNA (5) produces multiple WT1 protein ...
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6 Alternative splicing of Wilms tumor suppressor 1 (Wt1) exon 4 ...
https://www.sciencedirect.com/science/article/pii/S0012160614003224
The presence of alternative splicing of wt1a exon 4 in most fish suggests that the resulting protein isoforms might have differential functions.
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7 Two Splice Variants of the Wilms' Tumor 1 Gene Have Distinct ...
https://www.cell.com/abstract/S0092-8674(01)00453-6
Alternative splicing of Wt1 results in the insertion or omission of the three amino acids KTS between zinc fingers 3 and 4. In vitro experiments suggest ...
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8 DEK and WT1 Affect Alternative Splicing of Genes Involved in ...
https://ashpublications.org/blood/article/120/21/2392/112623/DEK-and-WT1-Affect-Alternative-Splicing-of-Genes
DEK and WT1 Affect Alternative Splicing of Genes Involved in Hematopoietic Cell Lineage and Resistance to Chemotherapy in Acute Myeloid Leukemia ...
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9 WT1, a Multiform Protein. Contribution of Genetic Models to ...
https://jasn.asnjournals.org/content/13/8/2192
WT1 is a complex gene that can encode at least 24 isoforms as a result of alternative start sites, alternative splicing (3,4), and RNA ...
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10 Frasier Syndrome is Caused by Defective Alternative Splicing ...
https://academic.oup.com/hmg/article/7/4/709/901100
The presence of alternative splice site mutations in Frasier syndrome highlights the importance of a precisely balanced expression of WT1 isoforms for its ...
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11 Modulation of DNA Binding Specificity by Alternative Splicing ...
https://www.science.org/doi/10.1126/science.1321494
The technique of whole-genome polymerase chain reaction was used to study the DNA binding properties of the product of the wt1 gene.
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12 Alternatively spliced isoforms of WT1 control podocyte-specific ...
https://www.kidney-international.org/article/S2157-1716(15)32169-9/fulltext
Transcriptional profiling of mice lacking the WT1 alternative splice isoform (+KTS) had a more restrictive set of genes whose expression depends on these ...
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13 Differential isoform expression and alternative splicing in sex ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-019-5572-x
Moreover, certain transcription factors important for sex determination in mammals, such as Wt1, Sry and Sox6, control mRNA splicing [8, 9].
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14 WT1 Alternative Splicing: Role of Its Isoforms in Neuroblastoma.
https://europepmc.org/article/med/28534317
WT1 Alternative Splicing: Role of Its Isoforms in Neuroblastoma. ... Wilms tumor 1 (WT1), a tumor suppressor gene, was originally identified in the ...
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15 Identification of a Novel C-Terminal Truncated WT1 Isoform ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130578
There are four major WT1 isoforms resulting from alternative splicing at two sites, exon 5 (17AA) and exon 9 (KTS). All major WT1 isoforms ...
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16 Distinct global binding patterns of the Wilms tumor gene 1 (WT1)
https://www.haematologica.org/article/view/7973
acts as an oncogene in acute myeloid leukemia. A naturally occurring alternative splice event between zinc fingers three and four, ...
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17 The complex life of WT1 | Journal of Cell Science
https://journals.biologists.com/jcs/article/116/9/1653/34461/The-complex-life-of-WT1
Alternative splicing of exon 5, however, might not modify WT1 function dramatically. Recently, it was also described that reduction of WT1 ...
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18 Alternative splicing and genomic structure of the Wilms tumor
https://www.jstor.org/stable/2357854
However, functional analysis of the WT1 gene product is complicated by the existence of four distinct transcripts, which result from alternative splicing.
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19 Do intronic mutations affecting splicing of WT1 exon 9 cause ...
https://jmg.bmj.com/content/35/1/45
The WT1 gene, one of the genes responsible for Wilms tumour, is thought to play a crucial role in the ... These mutations affect alternative splicing.
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20 Alternative splicing of Wilms tumor suppressor 1 (Wt1) exon 4 results ...
https://www.leibniz-hki.de/en/publication.html?publication=568
In mammals Wt1 comprises 10 exons with two characteristic splicing events: inclusion or skipping of exon 5 and alternative usage of two splice donor sites ...
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21 Differential Function of Wilms Tumor Gene WT1 Splice ...
https://www.jbc.org/article/S0021-9258(17)35436-4/fulltext
WT1 mRNA undergoes alternative splicing at two locations, yielding four different mRNA species and protein products. One alternative splice ...
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22 WT1 Alternative Splicing: Role of Its Isoforms in Neuroblastoma
https://www.researchgate.net/publication/317097171_WT1_Alternative_Splicing_Role_of_Its_Isoforms_in_Neuroblastoma
Request PDF | WT1 Alternative Splicing: Role of Its Isoforms in Neuroblastoma | Wilms tumor 1 (WT1), a tumor suppressor gene, was originally ...
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23 A Mammal-Specific Exon of WT1 Is Not Required for ...
https://journals.asm.org/doi/10.1128/MCB.22.12.4433-4438.2002
It encodes a zinc finger-containing nuclear protein with DNA- and RNA-binding activity. Two alternative splicing events within this gene result in the ...
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24 Differential splicing of exon 5 of the Wilms tumour (WT1
https://onlinelibrary.wiley.com/doi/pdf/10.1002/%28SICI%291098-2264%28199708%2919%3A4%3C256%3A%3AAID-GCC8%3E3.0.CO%3B2-W
The WT1 gene encodes a developmentally regulated transcription factor whose function is altered by alternative splicing at two.
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25 Aberrant Alternative Splicing Is Another Hallmark of Cancer
https://www.hindawi.com/journals/ijcb/2013/463786/
Thus, both a known oncogene (Myc) and tumour suppressor transcription factor (WT1) can regulate the expression of the oncogenic splice factor SRSF1 and of SRPK1 ...
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26 HuR antagonizes the effect of an intronic pyrimidine-rich ...
https://www.tandfonline.com/doi/full/10.1080/15476286.2015.1102831
WT1 + KTS and −KTS isoforms only differ in 3 amino acids in protein ... There are 2 major alternative splicing events in WT1 pre-mRNA, the first one refers ...
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27 New insights into the function of the Wilms tumor suppressor ...
https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00597.2007
diseases arise from mutations of the WT1 gene, including mutations that affect its zinc-fingers and alternative splicing of +/JKTS isoforms.
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28 Wilms' tumour - the splicing connection? - CORE
https://core.ac.uk/download/pdf/82731169.pdf
Major isoforms of WT1 - products of the tumour suppressor gene WT1, ... interact with splicing factors, suggesting a role for WT1 in RNA processing.
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29 WT1 - Wilms tumor protein - Homo sapiens (Human) | UniProtKB
https://www.uniprot.org/uniprotkb/P19544/entry
... may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921)
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30 Alternative RNA splicing defects in pediatric cancers
https://www.annalsofoncology.org/article/S0923-7534(22)00390-8/fulltext
Alternative splicing has been increasingly implicated in pediatric ... Use of alternative splice sites after exons 5 or 9 of WT1 in Wilms' ...
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31 Expression of the WT1 gene -KTS domain isoforms ...
https://www.spandidos-publications.com/10.3892/ijo.32.2.349/download
rise to four different splice isoforms. The inclusion of exon 5 inserts 17 amino acids, while the usage of an alternate splice.
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32 The ratio of ±KTS splice variants of the Wilms' tumour ...
https://cdnsciencepub.com/doi/abs/10.1139/O08-075
Alternative splicing of the primary transcript of the Wilms' tumour suppressor gene WT1 involving 2 overlapping 5′ splice sites at the end of exon 9 results ...
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33 Alternative splicing and genomic structure of the Wilms tumor gene ...
https://m.wikidata.org/wiki/Q37611742
Alternative splicing and genomic structure of the Wilms tumor gene WT1. scientific article. In more languages. Spanish. No label defined.
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34 Modulation of Dna-Binding Specificity by Alternative Splicing ...
https://espace.library.uq.edu.au/view/UQ:247941
The technique of whole-genome polymerase chain reaction was used to study the DNA binding properties of the product of the wt1 gene.
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35 WT1 (Wilms tumor suppressor gene)
https://atlasgeneticsoncology.org/gene/78/wt1-(wilms-tumor-suppressor-gene)
heterozygous point mutations of alternative splice donor site in exon 9 with imbalance of WT1 isoform ratio. Oncogenesis.
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36 Frasier syndrome is caused by defective alternative splicing of ...
https://www.semanticscholar.org/paper/Frasier-syndrome-is-caused-by-defective-alternative-Klamt-Koziell/edc1287b556b7dde1f3faaccff7b3abae6a92c98
Disruption of alternative splicing at the exon 9 splice donor site ... The splice mutation leads to an imbalance of WT1 isoforms in vivo ...
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37 Role of Alternative Splicing in Sex Determination in Vertebrates
https://www.karger.com/Article/Abstract/519218
The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation. Mol Cell Biol . 1999;19:2289–99.
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38 Mechanisms of transcriptional regulation by WT1 (Wilms ...
https://portlandpress.com/biochemj/article/461/1/15/46722/Mechanisms-of-transcriptional-regulation-by-WT1
At least 24 isoforms of WT1 are generated by a combination of alternative translation start sites, alternative RNA splicing and RNA editing.
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39 WT1 - wikidoc
https://www.wikidoc.org/index.php/WT1
Multiple transcript variants, resulting from alternative splicing at two ... Wilms tumour tumor suppressor gene1 (WT1) causes an embryonic ...
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40 Altered VEGF Splicing Isoform Balance in Tumor Endothelium ...
https://www.mdpi.com/2073-4409/8/1/41
... different VEGF isoforms with distinct angiogenic properties are produced through alternative splicing. In podocytes, the Wilms' tumor suppressor 1 (WT1) ...
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41 Lessons Learned from the Wilms' Tumor Gene, WT1 - Frontiers
https://www.frontiersin.org/articles/10.3389/fnmol.2011.00004/full
WT1 encodes a zinc finger protein, of which multiple isoforms exist due to alternative mRNA splicing in addition to translational and ...
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42 WT1 interacts with the splicing factor U2AF65 in an isoform ...
https://www.research.ed.ac.uk/en/publications/wt1-interacts-with-the-splicing-factor-u2af65-in-an-isoform-depen
WT1 is alternatively spliced and isoforms that include three amino acids, KTS, show stronger interaction ... U2AF65; WT1; SPLICEOSOME; Alternative Splicing ...
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43 WT1 Alternative Splicing: Role of Its Isoforms in Neuroblastoma
https://ouci.dntb.gov.ua/en/works/7q2BgpQ4/
WT1 Alternative Splicing: Role of Its Isoforms in Neuroblastoma ... K (1997) Donor splice-site mutations in WT1 are responsible for Frasier syndrome.
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44 Expression in Xenopus oocytes shows that WT1 binds ...
https://jcs.biologists.org/content/116/8/1539.full.pdf
alternative splice that inserts three amino acids (KTS) at the C- ... interacts with splice factors and that WT1 zinc fingers, particularly zinc finger one, ...
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45 WT1 modulates apoptosis by transcriptionally upregulating the ...
https://www.embopress.org/doi/10.1093/emboj/18.14.3990
The WT1 gene yields four alternatively spliced mRNAs: WT1-A, which contains neither alternative splice; WT1-B, which includes an N-terminal splice which ...
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46 The role of the Wilms tumour gene (WT1) in normal and ...
https://www.cambridge.org/core/journals/expert-reviews-in-molecular-medicine/article/role-of-the-wilms-tumour-gene-wt1-in-normal-and-malignant-haematopoiesis/61E238CF6C33614202C46D8BF020E21E
The relative locations of the alternatively spliced regions are shown. Protein isoforms. The WT1 mRNA undergoes alternative splicing at two independent sites ( ...
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47 The role of WT1 in breast and other cancers
http://smj.medicine.psu.ac.th/index.php/smj/article/view/273
Alternative splicing of the WT1 transcript generates four major protein isoforms and thirty six minor protein isoforms, each having different functional ...
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48 Significance of alternative splicing in cancer cells
https://journals.lww.com/cmj/fulltext/2020/01200/significance_of_alternative_splicing_in_cancer.13.aspx
The other VEGF splice variant, VEGF165, is proangiogenic and can be mediated by the transcription factor Wilms tumor 1 (WT1). In the absence of ...
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49 WT1 Gene - GeneCards | WT1 Protein | WT1 Antibody
https://www.genecards.org/cgi-bin/carddisp.pl?gene=WT1
Complete information for WT1 gene (Protein Coding), WT1 Transcription Factor, including: function, proteins, ... Alternative splice isoforms for WT1 Gene.
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50 Wilms tumor protein - Wikipedia
https://en.wikipedia.org/wiki/Wilms_tumor_protein
Wilms tumor protein (WT33) is a protein that in humans is encoded by the WT1 gene on ... WT1. Protein WT1 PDB 1xf7.png ... RNA expression pattern.
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51 BMRB Search
http://www.bmrb.wisc.edu/search/simplesearch.php?bmrbid=&show_bmrbid=on&show_title=on&dbname=PDB&pdbid=&title=&author=&molecule=WT1&output=html
50236, WT1-KTS RNA complex ; 50405, Alternative splicing of Wilms' tumor suppressor protein modulates DNA binding activity through isoform-specific DNA-induced ...
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52 WT1 interacts with the splicing protein RBM4 and regulates it..
https://inis.iaea.org/search/search.aspx?orig_q=RN:38030221
... major isoforms: WT1(-KTS), a transcription factor, and WT1(+KTS), a post-transcriptional regulator that binds to RNA and can interact with splicing co.
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53 Ras Promotes Growth by Alternative Splicing-Mediated ...
https://www.gastrojournal.org/article/S0016-5085(08)00246-1/abstract
KLF6 alternative splicing is not coupled to its transcriptional regulation. ... Life, sex, and WT1 isoforms. Cell. 2001; 106: 391-394.
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54 WT1 regulates angiogenesis in Ewing Sarcoma | Oncotarget
https://www.oncotarget.com/article/1610/text/
Multiple WT1 isoforms can be generated from two independent alternative splicing events [11] and the use of multiple translation initiation ...
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55 Tumor Suppressor WT1 | Encyclopedia MDPI
https://encyclopedia.pub/entry/12362
Wilms' tumor suppressor 1 (Wt1) heart cardiac development coronary vessel ... Alternative splicing of exon 5 and exon 9 gives rise to major isoforms.
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56 Chasing Alternative Splicing in Cancer Simplified Full length ...
https://www.youtube.com/watch?v=e3sxKQ76Njs
Dec 4, 2017
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57 连环蛋白1（CTNNB1）基因- Gene - MCE
https://www.medchemexpress.cn/gene/1499.html
This gene has 56 transcripts (splice variants), 273 orthologues, 4 paralogues and is ... Alternative splicing results in multiple transcript variants.
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58 Alternative splicing - YouTube
https://www.youtube.com/watch?v=GT_jmOQH4Zg
Shomu's Biology
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59 Revealing mRNA alternative splicing complexity in the human ...
https://www.youtube.com/watch?v=xT3btFYym7c
Oxford Nanopore Technologies
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60 Study of spliceosome-targeting cancer therapies reveals an ...
https://blogs.bcm.edu/2021/01/19/from-the-labs-study-of-spliceosome-targeting-cancer-therapies-reveals-an-overlooked-role-mis-spliced-rnas-themselves-may-play-in-tumor-cell-sensitivity/
Endogenous mis-spliced RNA in tumor cells mimics an RNA virus, leading tumor cells to self-destruct as if fighting an infection.
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61 Chromatin: Structure and Function - Page 170 - Google Books Result
https://books.google.com/books?id=cY2WLTwo0EIC&pg=PA170&lpg=PA170&dq=wt1+alternative+splicing&source=bl&ots=E743gj531v&sig=ACfU3U3Ssq5bWBkBOma0DZWusYSgFK3BcA&hl=en&sa=X&ved=2ahUKEwjphNLAwuH7AhX4TaQEHcOaBlcQ6AF6BAgvEAM
Alternative splicing gives rise to four WT1 isoforms dependent on the inclusion or omission of two motifs: 17 amino acids encoded by exon 5 included ...
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62 Molecular Biology of Human Cancers: An Advanced Student's ...
https://books.google.com/books?id=XsbzAjEe-sAC&pg=PA249&lpg=PA249&dq=wt1+alternative+splicing&source=bl&ots=-8vvp5Ufrl&sig=ACfU3U21Bcs3hMgaNmpw9SinGASoFKLLQw&hl=en&sa=X&ved=2ahUKEwjphNLAwuH7AhX4TaQEHcOaBlcQ6AF6BAgxEAM
WT1, however, contains both an activator and a repressor domain. Moreover, the protein binds to RNA and may regulate splicing. There are, in fact, ...
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63 The Genetics and Biology of Sex Determination
https://books.google.com/books?id=lc5Bg-hmsBYC&pg=PA25&lpg=PA25&dq=wt1+alternative+splicing&source=bl&ots=PAg9ZKNX8t&sig=ACfU3U3iwfcvPFkwhTY0aXUl66lVyMPDFQ&hl=en&sa=X&ved=2ahUKEwjphNLAwuH7AhX4TaQEHcOaBlcQ6AF6BAgwEAM
Structure of WT1 and its various isoforms . ( A ) Through a combination of alternative splicing ( exon 5 and exon 9 ) RNA editing ( exon 6 ) and three ...
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64 Sertoli Cell Biology - Page 63 - Google Books Result
https://books.google.com/books?id=AtFZw7hlQZAC&pg=PA63&lpg=PA63&dq=wt1+alternative+splicing&source=bl&ots=qpUmjX_m0s&sig=ACfU3U3a5dCtR0O3Kd--R73jCmlVojZBuQ&hl=en&sa=X&ved=2ahUKEwjphNLAwuH7AhX4TaQEHcOaBlcQ6AF6BAg0EAM
Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/–KTS splice isoforms. Hum. Mol. Genet.
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65 Kidney Transplantation - Principles and Practice E-Book
https://books.google.com/books?id=8X2zAQAAQBAJ&pg=PA638&lpg=PA638&dq=wt1+alternative+splicing&source=bl&ots=up4Obwhv_t&sig=ACfU3U1YY4qvz_YiBAtUpNsR5OCXKKFzBA&hl=en&sa=X&ved=2ahUKEwjphNLAwuH7AhX4TaQEHcOaBlcQ6AF6BAgtEAM
Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/–KTS splice isoforms. Hum Mol Genet 1998;7:709–14.
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66 Computational and Statistical Approaches to Genomics
https://books.google.com/books?id=GODpBwAAQBAJ&pg=PA293&lpg=PA293&dq=wt1+alternative+splicing&source=bl&ots=9vckP7IvBu&sig=ACfU3U3dtl_97x5yKLRs6-xMR8qslR9Wrg&hl=en&sa=X&ved=2ahUKEwjphNLAwuH7AhX4TaQEHcOaBlcQ6AF6BAgsEAM
Jiang, Z. H. , Wu, J. Y. (1999) Alternative splicing and programmed cell death. ... Lee, S. B. , Haber, D. A. (2001) Wilms tumor and the WT1 gene.
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67 Cumulated Index Medicus
https://books.google.com/books?id=NUemQsEaCtIC&pg=PA2174&lpg=PA2174&dq=wt1+alternative+splicing&source=bl&ots=IidRqpGSJO&sig=ACfU3U1pWy0-eiUT6Ii10jDqcTKM7KrU6Q&hl=en&sa=X&ved=2ahUKEwjphNLAwuH7AhX4TaQEHcOaBlcQ6AF6BAgrEAM
entre are i ཨ 5 ; NY transcript alternative splicing . ... inducible nitric oxide Differential effects of Wilms tumor WT1 splice variants on ( GLT - 1 ) .
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68 Alternative pre-mRNA Splicing: Theory and Protocols
https://books.google.com/books?id=_RXRdUIV8JEC&pg=PA257&lpg=PA257&dq=wt1+alternative+splicing&source=bl&ots=8DZGfaIfDx&sig=ACfU3U0LpEq2UT_8PWp84C9v2mp-eMeFcw&hl=en&sa=X&ved=2ahUKEwjphNLAwuH7AhX4TaQEHcOaBlcQ6AF6BAguEAM
23.1 Examples ofchanging alternative splicing (AS) patterns in ... RSp31, RSZ33, and SRp30. wt1⁄4wild-type plant, and AS1, AS2 and à correspond to the ...
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