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1 FGF21 improves glucose homeostasis in an obese ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/28770320/
FGF21 prevents the onset of diet-induced diabetes, without changing body fat mass. Beneficial effects are mediated via white adipose tissue browning and ...
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2 The Role of Fibroblast Growth Factor 21 in Diabetic ... - Frontiers
https://www.frontiersin.org/articles/10.3389/fendo.2021.598008/full
Endogenous FGF21 has been proposed to be a hormone to maintain lipid and glucose metabolism under both physiological and pathological conditions ...
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3 A novel GLP-1 and FGF21 dual agonist has therapeutic ...
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(20)30578-8/fulltext
Fibroblast growth factor 21 (FGF21) has become a promising therapeutic target for metabolic diseases such as type 2 diabetes (T2D), ...
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4 FGF21 gene therapy as treatment for obesity and insulin ...
https://www.embopress.org/doi/10.15252/emmm.201708791
Prevalence of type 2 diabetes (T2D) and obesity is increasing worldwide. Currently available therapies are not suited for all patients in the heterogeneous ...
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5 Treating Diabetes and Obesity with an FGF21-Mimetic ...
https://www.science.org/doi/10.1126/scitranslmed.3004690
Fibroblast growth factor 21 (FGF21) is a distinctive member of the FGF family with potent beneficial effects on lipid, body weight, and glucose metabolism and ...
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6 FGF21 improves glucose homeostasis in an ... - Springer Link
https://link.springer.com/article/10.1007/s00125-017-4389-x
FGF21 targets a variety of different organs. As recently reviewed in [12, 13], exogenously administered FGF21 acts directly on adipose tissue to ...
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7 FGF21 as a mediator of adaptive responses to stress and ...
https://joe.bioscientifica.com/view/journals/joe/226/1/R1.xml
FGF21 levels are also increased by several anti-diabetic drugs or compounds. Consequently, elevated FGF21 plays an adaptive role in response to diverse ...
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8 Serum fibroblast growth factor 21 levels are related to ...
https://cardiab.biomedcentral.com/articles/10.1186/s12933-015-0229-9
Serum FGF21 is elevated in newly diagnosed type 2 diabetes, and positively correlates with carotid and iliac lesions in patients with ...
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9 Circulating FGF21 Is Liver Derived and Enhances Glucose ...
https://diabetesjournals.org/diabetes/article/63/12/4057/40431/Circulating-FGF21-Is-Liver-Derived-and-Enhances
FGF21 is being pursued as a therapeutic target for diabetes and obesity because of its rapid and potent effects on improving insulin sensitivity ...
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10 Serum Fibroblast Growth Factor 21 Levels Are Positively ...
https://www.hindawi.com/journals/ije/2019/5163245/
Fibroblast growth factor 21 (FGF21) acts as a potent metabolic regulator. Serum FGF21 levels were significantly higher in obesity and type 2 diabetes ...
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11 Association between serum fibroblast growth factor 21 level ...
https://drc.bmj.com/content/9/1/e002126
Serum FGF21 level was found to be positively associated with the severity of DR in Chinese patients with type 2 diabetes. Additionally, serum FGF21 level is a ...
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12 AKR-001, an Fc-FGF21 Analog, Showed Sustained ...
https://www.cell.com/cell-reports-medicine/pdfExtended/S2666-3791(20)30073-2
and Lipid Metabolism in Type 2 Diabetes Patients ... in adipose tissue.3,4 Endogenous FGF21 concentrations in.
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13 FGF21–Sirtuin 3 Axis Confers the Protective Effects of ...
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.059631
Background: Exercise is an effective nonpharmacological strategy to alleviate diabetic cardiomyopathy (DCM) through poorly defined ...
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14 FGF21-FGFR4 signaling in cardiac myocytes ... - Nature
https://www.nature.com/articles/s41598-022-11033-x
Diabetes is a risk factor for congestive heart failure, and cardiovascular complications are the leading cause of diabetes-related morbidity and ...
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15 Roles of FGF21 and irisin in obesity-related diabetes and pa...
https://journals.lww.com/jpancreatology/Fulltext/2020/03000/Roles_of_FGF21_and_irisin_in_obesity_related.4.aspx
It is reported FGF21 improves metabolic phenotypes via lowering fasting glucose, insulin, and triacylglycerol levels in different obese mice models and diabetic ...
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16 FGF21 Normalizes Plasma Glucose in Mouse Models of Type ...
https://academic.oup.com/endo/article/162/9/bqab092/6267686
Fibroblast growth factor (FGF) 21 is a member of the FGF family of proteins. ... FGF21, type 1 diabetes, insulin receptor, type-A insulin resistance, ...
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17 Therapeutic Effects of Fibroblast Growth Factor-21 on Diabetic ...
https://www.e-dmj.org/journal/view.php?number=1736
It is reported that FGF21 has a protective effect on diabetes-induced damages via AMPK-SIRT1 in different tissues [37]. Another study showed ...
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18 FGF21 regulates PGC-1α and browning of white adipose ...
http://genesdev.cshlp.org/content/26/3/271
FGF21 Normalizes Plasma Glucose in Mouse Models of Type 1 Diabetes and Insulin Receptor Dysfunction bioRxiv February 3, 2021 0: 2021.01.04.425295v2-2021.01.
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19 Relationship between FGF21 and drug or nondrug therapy of ...
https://onlinelibrary.wiley.com/doi/full/10.1002/jcp.29879
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with a high incidence, and insulin resistance is an important feature (Cho et al.
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20 Advances in Biological Functions and Clinical Studies of FGF21
https://www.dovepress.com/advances-in-biological-functions-and-clinical-studies-of-fgf21-peer-reviewed-fulltext-article-DMSO
Abstract: Fibroblast growth factor 21 (FGF21) regulates many crucial ... FGF21 expression is decreased in patients with type 1 diabetes ...
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21 FGF21 Normalizes Plasma Glucose in Mouse ... - bioRxiv
https://www.biorxiv.org/content/10.1101/2021.01.04.425295v1
FGF21 Normalizes Plasma Glucose in Mouse Models of Type 1 Diabetes and Insulin Receptor Dysfunction. John L Diener, Sarah Mowbray, ...
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22 FGF21 contributes to metabolic improvements elicited by ...
https://journals.physiology.org/doi/10.1152/ajpendo.00050.2022
Fibroblast growth factor 21 (FGF21) is increased acutely by carbohydrate ingestion and is elevated in patients with type 2 diabetes (T2D).
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23 FGF21 and Chronic Kidney Disease - Metabolism
https://www.metabolismjournal.com/article/S0026-0495(21)00038-X/fulltext
FGF21 increases from early-stage CKD and predicts renal progression in diabetes and all-cause mortality in ESRD patients.
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24 FGF21 serum levels are related to insulin resistance ... - PLOS
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252144
An increase in insulin levels has been observed in obesity and type 2 diabetes [16, 17]. As such, FGF21 therapy has been studied as a ...
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25 Interplay between FGF21 and insulin action in the liver ... - JCI
https://www.jci.org/articles/view/67353
A placebo-controlled, double-blind randomized study of 40 patients with obesity and type 2 diabetes revealed that amlexanox treatment produced a significant 0.5 ...
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26 Effects of insulin and exercise training on FGF21, its receptors ...
https://www.siditalia.it/images/target_genes.pdf
However, the expres- sion of most FGF21 target genes was unaltered except for reduced CIDEA expression in individuals with type 2 diabetes. Conclusions/ ...
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27 Novel Adipokines CTRP1, CTRP9, and FGF21 in Pediatric ...
https://www.karger.com/Article/FullText/522665
Introduction: Pediatric obesity and diabetes has increased over the last several decades. While the role of common adipokines on metabolic parameters has ...
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28 FGF21-receptor agonists: an emerging therapeutic class for ...
https://www.degruyter.com/document/doi/10.1515/hmbci-2017-0002/html?lang=en
Fibroblast growth factor 21 (FGF21) analogs and FGF21 receptor ... the new “FGF21-class” of anti-obesity and anti-diabetic molecules that ...
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29 Mice Lacking FGF21 Are More Insulin Resistant Than Wild ...
https://professional.diabetes.org/abstract/mice-lacking-fgf21-are-more-insulin-resistant-wild-type-mice-when-fed-low-carbohydrate-high
Mice Lacking FGF21 Are More Insulin Resistant Than Wild-Type Mice When Fed a Low-Carbohydrate, High-Fat Ketogenic Diet ... Copyright 1995–2022. American Diabetes ...
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30 FGF21-FGFR4 signaling in cardiac myocytes ... - Scholars@UAB
https://scholars.uab.edu/display/pub2491966
Fibroblast growth factor (FGF) 21, a hormone that increases insulin ... we find that in type 2 diabetes (T2D) in mice, where serum FGF21 levels are elevated ...
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31 FGF21 activation-mediated islet autophagy in Type 2 diabetes ...
https://www.future-science.com/doi/10.4155/fmc-2018-0491
lipid · mTOR · obesity · pancreatic islets · Type 2 diabetes. The FGF21 is a unique member of the FGF family, which is well known ...
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32 Fibroblast Growth Factor 21 (FGF21) Administration Sex ...
https://www.mdpi.com/2073-4409/10/12/3440
FGF21 is a promising candidate for treating obesity, diabetes, and NAFLD; however, some of its pharmacological effects are sex-specific in mice with the Ay ...
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33 FGF21 action on human adipose tissue compromised by ...
https://www.endocrine-abstracts.org/ea/0031/ea0031p179
FGF21 action on human adipose tissue compromised by reduced βKlotho and FGFR1 expression in type 2 diabetes mellitus. Milan K Piya 1, , Alison L Harte 1 ...
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34 Effects of Glucagon-Like Peptide-1 Analogue and Fibroblast ...
https://www.e-enm.org/journal/view.php?doi=10.3803/EnM.2020.781
The fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid ... and FGF21 to mitigate the vascular complications of diabetes.
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35 Increased plasma FGF21 level as an early biomarker for ...
https://journals.sagepub.com/doi/10.1177/1479164118757152
Fibroblast growth factor 21 (FGF21) is known to be a key regulator of various ... in the models of obese insulin-resistant animals and diabetic animals.
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36 Loss of FGF21 in diabetic mouse during hepatocellular ...
https://e-century.us/files/ajcr/5/5/ajcr0007192.pdf
growth were also found in the hepatic tissues of diabetic OVE26 mice when DEN being administrated. FGF21 protein.
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37 Fibroblast Growth Factor 21 (FGF21) - Bristol Myers Squibb
https://www.bms.com/assets/bms/us/en-us/pdf/FGF21-factsheet.pdf
National Institute of Diabetes, Digestive and Kidney Diseases (Updated: May 2014). “Nonalcoholic Fatty Liver Disease & NASH.” Available at: https://www.niddk.
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38 Fibroblast Growth Factor (FGF21) - IBL-America
https://www.ibl-america.com/fibroblast-growth-factor-fgf21/
Solid phase sandwich ELISA for the determination human FGF21 in serum, EDTA plasma and cell culture supernatant. For research use only, not for use in ...
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39 Metabolic role of fibroblast growth factor 21 in liver, adipose ...
https://www.spandidos-publications.com/10.3892/br.2017.890
FGF21 was shown to exert the same metabolic effects in monkeys with diabetes mellitus. FGF21 reduced the concentration of low-density ...
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40 Opposite alterations in FGF21 and FGF19 levels and ...
http://www.ub.edu/tam/documents/article%20mes%20juliol%202014.pdf
OBJECTIVE: Fibroblast growth factor (FGF)-21, and possibly FGF19, protect against type 2 diabetes mellitus (T2DM) and obesity in rodents.
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41 New Roles for FGF21, a Well-Known Metabolic Molecule
https://www.buckinstitute.org/blog/old-dogs-new-tricks-new-roles-for-fgf21-a-well-known-metabolic-molecule/
Since diabetes is a metabolic disease, and FGF21 controls so many facets of our metabolism, do anti-diabetic medications depend on the ...
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42 6M6F: Solution structure of disulfide bond mutaion of the core ...
https://www.rcsb.org/structure/6m6f
... bond mutaion of the core domain of Fibroblast growth factor 21 (FGF21) ... folding modulation generates FGF21 variant against diabetes.
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43 Effect of Metformin on Fibroblast Growth Factor-21 Levels in ...
https://www.liebertpub.com/doi/10.1089/dia.2015.0261
In the present study, we investigated whether plasma levels of FGF-21 changed in patients with newly diagnosed type 2 diabetes mellitus ...
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44 UAB researchers cure type 2 diabetes and obesity in mice ...
https://www.uab.cat/web/newsroom/news-detail/uab-researchers-cure-type-2-diabetes-and-obesity-in-mice-using-gene-therapy-1345668003610.html?noticiaid=1345767330600
By inducing FGF21 production through gene therapy the animal lost weight and decreased insulin resistance, which causes the development of type ...
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45 Roles of FGF21 and irisin in obesity-related diabetes and ...
https://rs.yiigle.com/CN101560202001/1211570.htm
Compared with non-diabetic mice, serum FGF21 levels have been shown to increase in early-stage diabetes, but decrease in latestage diabetes, ...
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46 FGF21 protein may predict severity of NASH in obesity, diabetes
https://www.healio.com/news/endocrinology/20190318/fgf21-protein-may-predict-severity-of-nash-in-obesity-diabetes
“Plasma fibroblast growth factor 21 (FGF21) correlates with severe steatohepatitis in patients with nonalcoholic steatohepatitis (NASH), ...
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47 The role of Fibroblast growth factor 21 (FGF21) in diabetes ...
https://blogs.nottingham.ac.uk/lifesciences/2019/01/29/the-role-of-fibroblast-growth-factor-21-fgf21-in-diabetes-and-obesity/
Astonishingly, however, circulating FGF21 levels are increased during obese, diabetic (insulin resistance) and metabolic stress states2. This ...
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48 Fibroblast Growth Factor 21 and Its Association With Oxidative ...
https://www.cureus.com/articles/61662-fibroblast-growth-factor-21-and-its-association-with-oxidative-stress-and-lipid-profile-in-type-2-diabetes-mellitus
FGF-21 could be the target of certain medications used to treat metabolic disorders and obesity. Introduction. Diabetes mellitus is a ...
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49 High FGF21, Low Insulin And Glucose: A Pro-Longevity ...
https://www.youtube.com/watch?v=NreBsyaj0l0
Conquer Aging Or Die Trying!
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50 Summary of FGF21 physiology in mice and humans. In mice ...
https://www.researchgate.net/figure/Summary-of-FGF21-physiology-in-mice-and-humans-In-mice-consumption-of-a-ketogenic-diet_fig1_280602212
FGF21 expression in the liver is also induced by fatty liver disease, obesity, ... In humans, serum concentrations of FGF21 are higher in diabetes, obesity, ...
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51 FGF-21, Human - GenScript
https://www.genscript.com/protein/Z03157-FGF_21_Human.html
FGF-21 activates glucose uptake in adipocytes and increases insulin sensitivity, implicating it as a novel target with potential anti-diabetic properties.
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52 Perinatal Endocrinology and Pregnancy-Related Endocrine ...
https://books.google.com/books?id=twpxEAAAQBAJ&pg=PA27&lpg=PA27&dq=diabetes+fgf21&source=bl&ots=w80aljtcPd&sig=ACfU3U2PVM1jE_4GElIDKrxUJfwYae9DSQ&hl=en&sa=X&ved=2ahUKEwjP9dPj6eL7AhVDIn0KHQv-DrIQ6AF6BQj1ARAD
... 10.3389/fendo.2021.630287 FGF21 Serum Levels in the Early Second Trimester Are Positively Correlated With the Risk of Subsequent Gestational Diabetes ...
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53 Nutrition in the Prevention and Treatment of Abdominal Obesity
https://books.google.com/books?id=MzV8DwAAQBAJ&pg=PA151&lpg=PA151&dq=diabetes+fgf21&source=bl&ots=XDpKrLTYb4&sig=ACfU3U0BhU5hksSc2HkwUAdQY_DzMGqQPg&hl=en&sa=X&ved=2ahUKEwjP9dPj6eL7AhVDIn0KHQv-DrIQ6AF6BQjyARAD
Nrf2 represses FGF21 during long-term high-fat dietinduced obesity in mice. Diabetes. 2011;60(10):2465–2473. Schaap FG, Kremer AE, Lamers WH, et al.
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54 Adipokines—Advances in Research and Application: 2013 Edition
https://books.google.com/books?id=s_werKhgb7cC&pg=PA313&lpg=PA313&dq=diabetes+fgf21&source=bl&ots=MV4DHxIokL&sig=ACfU3U1_v4TfnLa9w0WLSe6e1avoy1EbSg&hl=en&sa=X&ved=2ahUKEwjP9dPj6eL7AhVDIn0KHQv-DrIQ6AF6BQj2ARAD
FGF21. Promotes. Metabolic. Homeostasis. via. White. Adipose. and. Leptin. in. Mice. By a News Reporter-Staff News Editor at Diabetes Week — Investigators ...
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55 Tag: FGF21 - Sabio lab
http://www.sabiolab.com/tag/fgf21/
› tag › fgf21
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56 Pheochromocytoma (PHEO) and Paraganglioma (PGL)
https://books.google.com/books?id=rAu_DwAAQBAJ&pg=PA88&lpg=PA88&dq=diabetes+fgf21&source=bl&ots=NKp1efvqSA&sig=ACfU3U08UyUSHctHOo-IsdSUCHNMy4MGrA&hl=en&sa=X&ved=2ahUKEwjP9dPj6eL7AhVDIn0KHQv-DrIQ6AF6BQj3ARAD
Relationship with plasma FGF21 and body adiposity. Diabetes 2011, 60,2758–2762. [CrossRef) [PubMed] Sarrus, D.A.; Thaler, J.P.; Morton, G.J.; German, J.; ...
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57 Extracellular Matrix Proteins—Advances in Research and ...
https://books.google.com/books?id=3pI2sBJTPYkC&pg=PA361&lpg=PA361&dq=diabetes+fgf21&source=bl&ots=IuB0-qmLVN&sig=ACfU3U3YUEVWcLCZwi_eoSoH6QDX433AwA&hl=en&sa=X&ved=2ahUKEwjP9dPj6eL7AhVDIn0KHQv-DrIQ6AF6BQj0ARAD
In vivo, diabetic double-knockout mice had significantly higher expression of renal FGF21 mRNA and protein compared with diabetic wild-type mice.
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58 Una nueva molécula mejoraría la diabetes mellitus tipo 2 y la ...
https://isanidad.com/137615/una-nueva-molecula-mejoraria-la-diabetes-mellitus-tipo-2-y-la-enfermedad-del-higado-graso-no-alcoholico/
Son dos patologías que suelen iniciarse por la obesidad y resistencia a la insulina. La alternativa presentada aumenta los niveles endógenos de la FGF21 ...
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59 Hepatic CPT1A Facilitates Liver–Adipose Cross Talk via ...
http://bbs.99lb.net/scholar/409083xs.html
期刊:Diabetes文献作者:Wei Sun; Tao Nie; Kuai Li; Wenjie Wu; Qiaoyun Long; ... Liver–Adipose Cross Talk via Induction of FGF21 in Mice.
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60 Mechanisms Of FGF21 mediated growth hormone resistance
https://www.pfizerplay.se/video/endokrinologi/mechanisms_of_fgf21_mediated_growth_hormone_resistance
Two new ways of using copeptin to discriminate between primary polydipsia and diabetes insipidus. daniel olsson endo 2018 endokrinologi.
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61 70. The Health Risks Of An Animal Based Diet... What Current ...
https://hungerhuntfeast.libsyn.com/70-the-health-risks-of-an-animal-based-diet-what-current-studies-tell-us
... diet despite lower autophagy and FGf21 levels Saturated Fats and ... or diabetes Total cholesterol in relation to mortality What the ...
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62 From feast to famine: A metabolic switch that may help ...
https://www.salk.edu/news-release/from-feast-to-famine-a-metabolic-switch-that-may-help-diabetes-treatment/
From feast to famine: A metabolic switch that may help diabetes treatment. Salk scientists find that a long-overlooked protein may be the ...
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63 Diabetes and Insulin-Like Growth Factor (IGF): Is There a Link?
https://www.healthline.com/health/igf-diabetes
Insulin-like growth factor (IGF) can affect your blood glucose levels. IGF may be used as a treatment for diabetes, but more research is necessary.
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64 Diabetes Medications and Support Programs | Eli Lilly and ...
https://www.lilly.com/disease-areas/diabetes
For more than 90 years, Lilly has been committed to diabetes and meeting the needs of people affected by diabetes with treatment options, support programs ...
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65 Type 2 Diabetes 2021 | MDedge Family Medicine
https://www.mdedge.com/familymedicine/article/233002/type-2-diabetes-2021
› familymedicine › article › typ...
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66 Type 2 Diabetes: Symptoms, Causes, Diagnosis, Diet, and ...
https://www.everydayhealth.com/type-2-diabetes/guide/
A person with prediabetes has up to a 50 percent chance of developing diabetes within 10 years. right up arrow. But it's possible to get your blood glucose ...
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