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1
The immune system as a driver of mitochondrial disease ...
https://ojrd.biomedcentral.com/articles/10.1186/s13023-022-02495-3
Mitochondrial dysfunction is evident in leukocytes from critically ill patients, and is believed to be the underlying cause of immunoparalysis ...
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https://ojrd.biomedcentral.com/articles/10.1186/s13023-022-02495-3
Mitochondrial dysfunction is evident in leukocytes from critically ill patients, and is believed to be the underlying cause of immunoparalysis ...
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2
The emerging role of immune dysfunction in ... - NCBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866745/
The emerging role of immune dysfunction in mitochondrial diseases as a paradigm for understanding immunometabolism. Metabolism. 2018 Apr;81:97- ...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866745/
The emerging role of immune dysfunction in mitochondrial diseases as a paradigm for understanding immunometabolism. Metabolism. 2018 Apr;81:97- ...
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3
Immune Function and Mitochondrial Disease - Mito Action
https://www.mitoaction.org/resources/immune-function-and-mitochondrial-disease/
However, there is limited published data on systematic analysis of immune system in patients with mitochondrial disease. Research focusing on the ...
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https://www.mitoaction.org/resources/immune-function-and-mitochondrial-disease/
However, there is limited published data on systematic analysis of immune system in patients with mitochondrial disease. Research focusing on the ...
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4
Diverse Roles of Mitochondria in Immune Responses - Frontiers
https://www.frontiersin.org/articles/10.3389/fimmu.2018.01605/full
Lack of immune system cells or impairment in differentiation of immune cells is the basis for many chronic diseases.
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https://www.frontiersin.org/articles/10.3389/fimmu.2018.01605/full
Lack of immune system cells or impairment in differentiation of immune cells is the basis for many chronic diseases.
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5
Basic mechanism of immune system activation by mitochondria
https://www.tandfonline.com/doi/full/10.1080/25785826.2020.1756609
Mitochondria are critical organelles that regulate the immune system. That is, they regulate signaling pathways and cell fate in both innate and ...
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https://www.tandfonline.com/doi/full/10.1080/25785826.2020.1756609
Mitochondria are critical organelles that regulate the immune system. That is, they regulate signaling pathways and cell fate in both innate and ...
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6
Children with Mitochondrial Disease and Recurrent Infections
https://www.jacionline.org/article/S0091-6749(09)01871-5/fulltext
RATIONALE: The generation of an immune response to infection requires enormous amounts of energy in the form of ATP. Children with mitochondrial disease ...
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https://www.jacionline.org/article/S0091-6749(09)01871-5/fulltext
RATIONALE: The generation of an immune response to infection requires enormous amounts of energy in the form of ATP. Children with mitochondrial disease ...
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7
Mitochondrial function in immune cells in health and disease
https://www.sciencedirect.com/science/article/pii/S0925443920301927
Via release of such DAMPs, mitochondria guide the immune response towards an inflammatory response against pathogens.
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https://www.sciencedirect.com/science/article/pii/S0925443920301927
Via release of such DAMPs, mitochondria guide the immune response towards an inflammatory response against pathogens.
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8
Mitochondrial Diseases: Causes, Symptoms, Diagnosis ...
https://my.clevelandclinic.org/health/diseases/15612-mitochondrial-diseases
Mitochondria are the “energy factory” of our body. Mitochondrial diseases are long-term, genetic, often inherited disorders that occur when ...
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https://my.clevelandclinic.org/health/diseases/15612-mitochondrial-diseases
Mitochondria are the “energy factory” of our body. Mitochondrial diseases are long-term, genetic, often inherited disorders that occur when ...
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9
Metabolism, Infection and Immunity (MINI) Section
https://www.genome.gov/current-NHGRI-Clinical-Studies/Metabolism-Infection-Immunity-Section
Infection in individuals with mitochondrial disease can lead to ... of immune system activation on end-organ mitochondrial metabolism; ...
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https://www.genome.gov/current-NHGRI-Clinical-Studies/Metabolism-Infection-Immunity-Section
Infection in individuals with mitochondrial disease can lead to ... of immune system activation on end-organ mitochondrial metabolism; ...
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10
What is Mitochondrial Disease?
https://mitochondrialdisease.nhs.uk/patient-area/what-mitochondrial-disease/
When a person has Mitochondrial Disease, the mitochondria in the cells are not producing enough energy. Sometimes they are not very efficient or they do not ...
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https://mitochondrialdisease.nhs.uk/patient-area/what-mitochondrial-disease/
When a person has Mitochondrial Disease, the mitochondria in the cells are not producing enough energy. Sometimes they are not very efficient or they do not ...
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11
Mitochondria and the Immune Response - Nature
https://www.nature.com/scitable/topicpage/mitochondria-and-the-immune-response-14266967/
Severe trauma releases mitochondrial DAMPs into the blood where they are recognized by innate immunity through PRRs and FPR1, which also sense bacteria. Because ...
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https://www.nature.com/scitable/topicpage/mitochondria-and-the-immune-response-14266967/
Severe trauma releases mitochondrial DAMPs into the blood where they are recognized by innate immunity through PRRs and FPR1, which also sense bacteria. Because ...
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12
Autoimmune disease and mitochondrial dysfunction in chronic ...
https://www.openaccessjournals.com/articles/autoimmune-disease-and-mitochondrial-dysfunction-in-chronic-diseases-12187.html
Autoimmune Disease and Mitophagy are now Relevant to the Irreversible Induction of Chronic Diseases. Anti-aging genes that maintain the immune system and ...
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https://www.openaccessjournals.com/articles/autoimmune-disease-and-mitochondrial-dysfunction-in-chronic-diseases-12187.html
Autoimmune Disease and Mitophagy are now Relevant to the Irreversible Induction of Chronic Diseases. Anti-aging genes that maintain the immune system and ...
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13
Mitochondrial Dysfunction and the Aging Immune System - MDPI
https://www.mdpi.com/2079-7737/8/2/26
Many of these mitochondrial functions decline with age, and are the basis for many diseases of aging. Despite the vast amount of research dedicated to this ...
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https://www.mdpi.com/2079-7737/8/2/26
Many of these mitochondrial functions decline with age, and are the basis for many diseases of aging. Despite the vast amount of research dedicated to this ...
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14
The COVID-19 Effect on the Immune System and ...
https://journals.sagepub.com/doi/full/10.1177/1073858420960443
Mitochondria can alter cellular respiration to effectively adapt macrophage response between proinflammatory and anti-inflammatory phenotypes. Even their ...
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https://journals.sagepub.com/doi/full/10.1177/1073858420960443
Mitochondria can alter cellular respiration to effectively adapt macrophage response between proinflammatory and anti-inflammatory phenotypes. Even their ...
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15
How mitochondrial damage ignites the 'auto-inflammatory fire'
https://www.sciencedaily.com/releases/2022/07/220713143955.htm
Together, NLRP3 and cGAS spur inflammation, which in autoimmune diseases has characteristically run amok, prompting the immune system to ...
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https://www.sciencedaily.com/releases/2022/07/220713143955.htm
Together, NLRP3 and cGAS spur inflammation, which in autoimmune diseases has characteristically run amok, prompting the immune system to ...
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16
Hypoxia as a therapy for mitochondrial disease - Science
https://www.science.org/doi/10.1126/science.aad9642
Jain et al. identified the hypoxia response, a mechanism that helps cells adapt when oxygen is limited, as a potent suppressor of mitochondrial dysfunction ...
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https://www.science.org/doi/10.1126/science.aad9642
Jain et al. identified the hypoxia response, a mechanism that helps cells adapt when oxygen is limited, as a potent suppressor of mitochondrial dysfunction ...
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17
Linking mitochondrial dysfunction to induction of the innate ...
https://www.ed.ac.uk/institute-genetics-cancer/news-and-events/news-2021/linking-mitochondrial-dysfunction
Mitochondria represent vestigial bacteria situated in the cytosol of ... immune system might be more relevant in 'mitochondrial disease' ...
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https://www.ed.ac.uk/institute-genetics-cancer/news-and-events/news-2021/linking-mitochondrial-dysfunction
Mitochondria represent vestigial bacteria situated in the cytosol of ... immune system might be more relevant in 'mitochondrial disease' ...
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18
Mitochondrial Disease - Seattle Children's
https://www.seattlechildrens.org/research/centers-programs/science-industry-partnerships/partnership-opportunities/mitochondrial-disease/
Mitochondrial diseases are highly varied, arising from mutations in hundreds of genes, and can lead to cellular damage in affected tissues.
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https://www.seattlechildrens.org/research/centers-programs/science-industry-partnerships/partnership-opportunities/mitochondrial-disease/
Mitochondrial diseases are highly varied, arising from mutations in hundreds of genes, and can lead to cellular damage in affected tissues.
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19
Immune Function Remodeled by Mitochondrial Shape
https://www.hopkinsmedicine.org/news/newsroom/news-releases/immune-function-remodeled-by-mitochondrial-shape
A new study focused on the immune system's Th17 cells suggests that the ... of cells) is important in autoimmune and inflammatory disorders, ...
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https://www.hopkinsmedicine.org/news/newsroom/news-releases/immune-function-remodeled-by-mitochondrial-shape
A new study focused on the immune system's Th17 cells suggests that the ... of cells) is important in autoimmune and inflammatory disorders, ...
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20
What is Mitochondrial Disease - Mito Foundation
https://www.mito.org.au/about-mito/mitochondrial-disease/
Mitochondrial disease (mito) is a debilitating and potentially fatal disease that reduces the ability of the mitochondria to produce this energy. When the ...
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https://www.mito.org.au/about-mito/mitochondrial-disease/
Mitochondrial disease (mito) is a debilitating and potentially fatal disease that reduces the ability of the mitochondria to produce this energy. When the ...
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21
Parkinson's Disease: Linking mitochondria to the immune ...
https://elifesciences.org/articles/56214
The cGAS–STING pathway is a part of the innate immune system that triggers the expression of inflammatory genes when DNA is detected in the ...
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https://elifesciences.org/articles/56214
The cGAS–STING pathway is a part of the innate immune system that triggers the expression of inflammatory genes when DNA is detected in the ...
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22
Primary Mitochondrial Disease and Secondary Mitochondrial ...
https://www.karger.com/Article/Fulltext/446586
Mitochondria are considered to be critical components of the innate immune response [Lane et al., 2015]. The immune system requires ...
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https://www.karger.com/Article/Fulltext/446586
Mitochondria are considered to be critical components of the innate immune response [Lane et al., 2015]. The immune system requires ...
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23
Mitochondrial perturbations enhance cell-mediated innate ...
https://www.biorxiv.org/content/10.1101/2022.07.19.500574v1
While mitochondrial dysfunction contributes to many diseases, ... due to the mitochondrial perturbations the cell-mediated immune system of ...
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https://www.biorxiv.org/content/10.1101/2022.07.19.500574v1
While mitochondrial dysfunction contributes to many diseases, ... due to the mitochondrial perturbations the cell-mediated immune system of ...
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24
Mitochondrial DNA in inflammation and immunity - EMBO Press
https://www.embopress.org/doi/10.15252/embr.201949799
Mitochondrial DNA as a stimulator of the immune system ... In humans, the systemic inflammatory disease Aicardi–Goutières syndrome (AGS) is ...
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https://www.embopress.org/doi/10.15252/embr.201949799
Mitochondrial DNA as a stimulator of the immune system ... In humans, the systemic inflammatory disease Aicardi–Goutières syndrome (AGS) is ...
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25
Chronic Diseases - The Effects Of Autoimmune Disease And ...
https://www.oapublishinglondon.com/pop/chronic-diseases/
p53 maintains the immune system and its mitochondrial function is linked to anti-aging genes. Sirt 1 is now linked to autoimmune disease, and ...
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https://www.oapublishinglondon.com/pop/chronic-diseases/
p53 maintains the immune system and its mitochondrial function is linked to anti-aging genes. Sirt 1 is now linked to autoimmune disease, and ...
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26
Phenotyping Mitochondrial and Immune Dysfunction in POTS ...
https://clinicaltrials.gov/show/NCT05409651
MedlinePlus related topics: Immune System and Disorders ... Exploratory Outcome: Characterize mitochondrial function in POTS patients [ Time ...
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https://clinicaltrials.gov/show/NCT05409651
MedlinePlus related topics: Immune System and Disorders ... Exploratory Outcome: Characterize mitochondrial function in POTS patients [ Time ...
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27
AIFM1 mutation presenting with fatal encephalomyopathy and ...
https://molecularcasestudies.cshlp.org/content/3/2/a001560.short
... and immune system regulation. Here we describe a patient with a novel AIFM1 variant presenting unusually early in life with mitochondrial disease, ...
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https://molecularcasestudies.cshlp.org/content/3/2/a001560.short
... and immune system regulation. Here we describe a patient with a novel AIFM1 variant presenting unusually early in life with mitochondrial disease, ...
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28
Patient care standards for primary mitochondrial disease
https://www.umdf.org/wp-content/uploads/2016/01/Patient-Care-Standards-for-Primary-Mitochondrial-Disease-GIM-2017.pdf
Body systems affected by primary mitochondrial disease. Mitochondrial disease patient care ... The immune system and its interplay with mitochondria.
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https://www.umdf.org/wp-content/uploads/2016/01/Patient-Care-Standards-for-Primary-Mitochondrial-Disease-GIM-2017.pdf
Body systems affected by primary mitochondrial disease. Mitochondrial disease patient care ... The immune system and its interplay with mitochondria.
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29
Mitochondrial Myopathy - BrainFacts.org
https://www.brainfacts.org/diseases-and-disorders/neurological-disorders-az/diseases-a-to-z-from-ninds/mitochondrial-myopathy
Mitochondrial myopathies are a group of neuromuscular diseases caused by damage to the mitochondria—small, energy-producing structures that serve as the ...
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https://www.brainfacts.org/diseases-and-disorders/neurological-disorders-az/diseases-a-to-z-from-ninds/mitochondrial-myopathy
Mitochondrial myopathies are a group of neuromuscular diseases caused by damage to the mitochondria—small, energy-producing structures that serve as the ...
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30
Covid 19 Health for Mito Patients - The Lily Foundation
https://www.thelilyfoundation.org.uk/coronavirus/coronavirus_advice/
It is therefore not expected that patients with mitochondrial disease will ... of highest risk of catching COVID-19 due to having a weakened immune system.
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https://www.thelilyfoundation.org.uk/coronavirus/coronavirus_advice/
It is therefore not expected that patients with mitochondrial disease will ... of highest risk of catching COVID-19 due to having a weakened immune system.
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31
Digging Deeper into Mitochondrial Dysfunction
http://www.hormonesmatter.com/digging-deeper-mitochondrial-dysfunction/
It's not Autoimmunity, but Impaired Immunity. I never much liked the war model of health and disease, but it seems to work well as metaphor for ...
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http://www.hormonesmatter.com/digging-deeper-mitochondrial-dysfunction/
It's not Autoimmunity, but Impaired Immunity. I never much liked the war model of health and disease, but it seems to work well as metaphor for ...
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32
Mitochondrial disorders of the OXPHOS system - FEBS Press
https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.13995
Mitochondrial disorders are among the most frequent inborn errors of metabolism, their primary cause being the dysfunction of the oxidative ...
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https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.13995
Mitochondrial disorders are among the most frequent inborn errors of metabolism, their primary cause being the dysfunction of the oxidative ...
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33
Role of MHC Class I in Immune Surveillance of Mitochondrial ...
https://www.jimmunol.org/content/jimmunol/170/7/3603.full.pdf
chondrial diseases in humans with enzyme deficiencies affecting mitochondrial ... immune system to eliminate cells with mitochondrial DNA mutations.
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https://www.jimmunol.org/content/jimmunol/170/7/3603.full.pdf
chondrial diseases in humans with enzyme deficiencies affecting mitochondrial ... immune system to eliminate cells with mitochondrial DNA mutations.
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34
Mitochondrial function in development and disease. Dis Model ...
https://hscrb.harvard.edu/publication/mitochondrial-function-in-development-and-disease-dis-model-mech-2021-jun-01-146/
Mitochondrial function in development and disease. ... of an innate immune response, all with a focus on development, disease and aging.
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https://hscrb.harvard.edu/publication/mitochondrial-function-in-development-and-disease-dis-model-mech-2021-jun-01-146/
Mitochondrial function in development and disease. ... of an innate immune response, all with a focus on development, disease and aging.
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35
Part III: Long COVID and Mitochondrial Dysregulation
https://www.zrtlab.com/blog/archive/long-covid-and-mitochondrial-dysregulation/
Mitochondria play a central role in the host response to viral infection and immunity, and function as a platform for immune signaling by ...
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https://www.zrtlab.com/blog/archive/long-covid-and-mitochondrial-dysregulation/
Mitochondria play a central role in the host response to viral infection and immunity, and function as a platform for immune signaling by ...
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36
Mitochondrial Impairment in Long COVID-19
https://www.ifm.org/news-insights/mitochondrial-impairment-in-long-covid-19/
Viral diseases, like SARS-CoV-2, are known for their ability to hijack and ... moderate physical activity enhances immune function and mitochondrial ...
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https://www.ifm.org/news-insights/mitochondrial-impairment-in-long-covid-19/
Viral diseases, like SARS-CoV-2, are known for their ability to hijack and ... moderate physical activity enhances immune function and mitochondrial ...
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37
Autoimmunity: The Mitochondrial Connection
https://ndnr.com/autoimmuneallergy-medicine/autoimmunity-the-mitochondrial-connection/
Autoimmune diseases are characterized by immune system hyperresponsiveness to the body's own tissues. While autoimmune diseases differ in terms ...
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https://ndnr.com/autoimmuneallergy-medicine/autoimmunity-the-mitochondrial-connection/
Autoimmune diseases are characterized by immune system hyperresponsiveness to the body's own tissues. While autoimmune diseases differ in terms ...
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38
Sirtuin 1 regulates mitochondrial function and immune ... - PLOS
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008319
Collectively, these findings expand our understanding of the mitochondrial mediated innate immune response during RSV infection and may ...
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https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008319
Collectively, these findings expand our understanding of the mitochondrial mediated innate immune response during RSV infection and may ...
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39
The Role of LRRK2 in Immune Response and ...
https://www.michaeljfox.org/grant/role-lrrk2-immune-response-and-neurodegeneration-caused-mitochondrial-dysfunction
Impact on Diagnosis/Treatment of Parkinson's Disease: We have linked mitochondrial dysfunction to a harmful immune response and neurodegeneration in ...
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https://www.michaeljfox.org/grant/role-lrrk2-immune-response-and-neurodegeneration-caused-mitochondrial-dysfunction
Impact on Diagnosis/Treatment of Parkinson's Disease: We have linked mitochondrial dysfunction to a harmful immune response and neurodegeneration in ...
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40
Module VI Drivers of Immune System and Mitochondrial ... - A4M
https://www.a4m.com/module-vi-drivers-of-immune-system-and-mitochondrial-dysregulation-los-angles-2020-a4m.html
Currently, there are 100+ autoimmune disorders all caused by the common thread of autoimmunity. Why the radical change in incidence? Module VI will review ...
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https://www.a4m.com/module-vi-drivers-of-immune-system-and-mitochondrial-dysregulation-los-angles-2020-a4m.html
Currently, there are 100+ autoimmune disorders all caused by the common thread of autoimmunity. Why the radical change in incidence? Module VI will review ...
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41
Beyond ATP, new roles of mitochondria | The Biochemist
https://portlandpress.com/biochemist/article/44/4/2/231672/Beyond-ATP-new-roles-of-mitochondria
ISR activation is linked to primary mitochondrial diseases. ... DNA and RNA can activate signalling cascades leading to immune response.
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https://portlandpress.com/biochemist/article/44/4/2/231672/Beyond-ATP-new-roles-of-mitochondria
ISR activation is linked to primary mitochondrial diseases. ... DNA and RNA can activate signalling cascades leading to immune response.
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42
Leigh Syndrome - National Organization for Rare Disorders
https://rarediseases.org/rare-diseases/leigh-syndrome/
Most individuals with Leigh syndrome have defects of mitochondrial energy production, ... Disease affecting the nerves outside of the central nervous system ...
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https://rarediseases.org/rare-diseases/leigh-syndrome/
Most individuals with Leigh syndrome have defects of mitochondrial energy production, ... Disease affecting the nerves outside of the central nervous system ...
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43
Mitochondrial Toxicity | Toxicological Sciences
https://academic.oup.com/toxsci/article/162/1/15/4798828
The relationship between mitochondria and the immune system is a rapidly growing field. It is now clear that mitochondria can act as crucial ...
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https://academic.oup.com/toxsci/article/162/1/15/4798828
The relationship between mitochondria and the immune system is a rapidly growing field. It is now clear that mitochondria can act as crucial ...
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44
Mitochondria as intracellular signaling platforms in health and ...
https://rupress.org/jcb/article/219/5/e202002179/151695/Mitochondria-as-intracellular-signaling-platforms
Undesired MAVS signaling in diseases. While mitochondria play protective roles in innate immune signaling, abnormal activation of this system ...
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https://rupress.org/jcb/article/219/5/e202002179/151695/Mitochondria-as-intracellular-signaling-platforms
Undesired MAVS signaling in diseases. While mitochondria play protective roles in innate immune signaling, abnormal activation of this system ...
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45
The role of mitochondria in aging - JCI
https://www.jci.org/articles/view/120842
There is increasing evidence that mitochondria might play an important role in the inflammaging phenotype (23). The immune system is capable of ...
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https://www.jci.org/articles/view/120842
There is increasing evidence that mitochondria might play an important role in the inflammaging phenotype (23). The immune system is capable of ...
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46
USC: findings help explain how COVID-19 overpowers the ...
https://gero.usc.edu/2021/01/08/covid-19-immune-system-mitochondria/
Future work should consider mitochondrial biology as a primary intervention ... “We already knew that our immune response was not mounting a ...
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https://gero.usc.edu/2021/01/08/covid-19-immune-system-mitochondria/
Future work should consider mitochondrial biology as a primary intervention ... “We already knew that our immune response was not mounting a ...
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47
Know thy mitochondria: Autoimmunity to organelles and their ...
https://medicalxpress.com/news/2020-01-thy-mitochondria-autoimmunity-organelles-dna.html
The immune system uses its mitochondria to self-stimulate innate and ... However, for other forms of the disease, like lupus nephritis, ...
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https://medicalxpress.com/news/2020-01-thy-mitochondria-autoimmunity-organelles-dna.html
The immune system uses its mitochondria to self-stimulate innate and ... However, for other forms of the disease, like lupus nephritis, ...
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48
Autoimmune Disease and Mitochondrial Dysfunction in ...
https://research-repository.uwa.edu.au/files/25571880/Autoimmune_disease_and_mitochondrial_dysfunction_in_chronic_diseases.pdf
Figure 1.Autoimmune Disease and Mitophagy are now Relevant to the Irreversible Induction of Chronic Diseases. Anti-aging genes that maintain the immune system ...
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https://research-repository.uwa.edu.au/files/25571880/Autoimmune_disease_and_mitochondrial_dysfunction_in_chronic_diseases.pdf
Figure 1.Autoimmune Disease and Mitophagy are now Relevant to the Irreversible Induction of Chronic Diseases. Anti-aging genes that maintain the immune system ...
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49
Benefits of Exercise May Vary Greatly in Primary Mitochondrial ...
https://neurosciencenews.com/exercise-mitochondrial-disease-20523/
Abstract. Mitochondrial mutations alter endurance exercise response and determinants in mice. Primary mitochondrial diseases ...
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https://neurosciencenews.com/exercise-mitochondrial-disease-20523/
Abstract. Mitochondrial mutations alter endurance exercise response and determinants in mice. Primary mitochondrial diseases ...
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50
Modulation of Mitochondria During Viral Infections - IntechOpen
https://www.intechopen.com/books/mitochondrial-diseases/modulation-of-mitochondria-during-viral-infections
Mitochondrial Diseases Edited by Eylem Taskin ... One defense mechanism is based on the immune system, and another is based on cell autonomy ...
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https://www.intechopen.com/books/mitochondrial-diseases/modulation-of-mitochondria-during-viral-infections
Mitochondrial Diseases Edited by Eylem Taskin ... One defense mechanism is based on the immune system, and another is based on cell autonomy ...
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51
Mitochondrial Disease as a Cause of Neonatal ... - Hindawi
https://www.hindawi.com/journals/cripe/2016/3932646/
Diagnosis of mitochondrial respiratory chain disorder (MRCD) is often difficult. ... disorder in an uncontrolled and ineffective immune response.
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https://www.hindawi.com/journals/cripe/2016/3932646/
Diagnosis of mitochondrial respiratory chain disorder (MRCD) is often difficult. ... disorder in an uncontrolled and ineffective immune response.
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52
Mitochondrial function in development and disease
https://journals.biologists.com/dmm/article/14/6/dmm048912/269120/Mitochondrial-function-in-development-and-disease
Given the importance of the innate immune system for the development of neurodegenerative diseases (Scheiblich et al., 2020), ...
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https://journals.biologists.com/dmm/article/14/6/dmm048912/269120/Mitochondrial-function-in-development-and-disease
Given the importance of the innate immune system for the development of neurodegenerative diseases (Scheiblich et al., 2020), ...
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53
New drugs offer hope for mitochondrial disease - STAT News
https://www.statnews.com/2016/02/11/mitochondrial-disease-therapies/
Women with mitochondrial disease could soon have a way to avoid passing their ... improving Jacob's communication skills and immune system, ...
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https://www.statnews.com/2016/02/11/mitochondrial-disease-therapies/
Women with mitochondrial disease could soon have a way to avoid passing their ... improving Jacob's communication skills and immune system, ...
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54
The Otolaryngological Manifestations of Mitochondrial ...
https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/482812
Mitochondrial disease followed an episodic course, with periods of stasis or ... or mucosal immune defect, or is secondary to impaired mucociliary function ...
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https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/482812
Mitochondrial disease followed an episodic course, with periods of stasis or ... or mucosal immune defect, or is secondary to impaired mucociliary function ...
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55
Neural vulnerability in Huntington's disease tied to release of ...
https://news.mit.edu/2020/neural-vulnerability-huntingtons-disease-tied-to-mitochondrial-rna-release-0721
... cells respond to the mutation that causes Huntington's disease, ... of immune response to mitochondrial RNA) in green than neurons on ...
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https://news.mit.edu/2020/neural-vulnerability-huntingtons-disease-tied-to-mitochondrial-rna-release-0721
... cells respond to the mutation that causes Huntington's disease, ... of immune response to mitochondrial RNA) in green than neurons on ...
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56
It can happen to ANYONE at ANYTIME - MitoCanada
https://mitocanada.org/wp-content/uploads/simple-file-list/MitoCanada_FAQs_Aug2018.pdf
You may have only recently heard of mitochondrial disease, but you surely have heard of Alzheimer's disease, ... immune system problems and liver disease.
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https://mitocanada.org/wp-content/uploads/simple-file-list/MitoCanada_FAQs_Aug2018.pdf
You may have only recently heard of mitochondrial disease, but you surely have heard of Alzheimer's disease, ... immune system problems and liver disease.
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57
Unraveling mitochondria's mysterious link to autism | Spectrum
https://www.spectrumnews.org/news/unraveling-mitochondrias-mysterious-link-to-autism/
Genetic mitochondrial diseases are as varied as they are rare. ... the disease is usually triggered by stresses to the immune system, ...
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https://www.spectrumnews.org/news/unraveling-mitochondrias-mysterious-link-to-autism/
Genetic mitochondrial diseases are as varied as they are rare. ... the disease is usually triggered by stresses to the immune system, ...
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58
Primary Mitochondrial Disorders of the Pediatric Central ...
https://pubs.rsna.org/doi/full/10.1148/rg.2020200052
Primary Mitochondrial Disorders of the Pediatric Central Nervous System: Neuroimaging Findings. Fabrício Guimarães Gonçalves ,; César ...
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https://pubs.rsna.org/doi/full/10.1148/rg.2020200052
Primary Mitochondrial Disorders of the Pediatric Central Nervous System: Neuroimaging Findings. Fabrício Guimarães Gonçalves ,; César ...
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59
Mitochondrial Dysfunction in Autism: Symptoms & Treatment
https://www.corticacare.com/care-notes/symptoms-of-mitochondrial-dysfunction
Symptoms in more than one organ system. Family members with diseases that have been linked to mitochondrial dysfunction. Alzheimer's disease, Parkinson's ...
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https://www.corticacare.com/care-notes/symptoms-of-mitochondrial-dysfunction
Symptoms in more than one organ system. Family members with diseases that have been linked to mitochondrial dysfunction. Alzheimer's disease, Parkinson's ...
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60
CME Mitochondrial Disease and Specialties - Part 1
https://umdf-mitou.teachable.com/p/umdf-mito-u-cmemitospecialities-part-1
Infection and Immunity in Mitochondrial Disease. Understand that the immune system is important for vaccination and protection against ...
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https://umdf-mitou.teachable.com/p/umdf-mito-u-cmemitospecialities-part-1
Infection and Immunity in Mitochondrial Disease. Understand that the immune system is important for vaccination and protection against ...
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61
Advancement in the diagnosis of mitochondrial diseases
https://jtggjournal.com/article/view/3508
Mitochondrial diseases can affect single or multiple organ systems, thus the association with ... the intestinal microbiota, and the immune system as well.
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https://jtggjournal.com/article/view/3508
Mitochondrial diseases can affect single or multiple organ systems, thus the association with ... the intestinal microbiota, and the immune system as well.
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62
Could Mitochondria Be the Key to a Healthy Brain?
https://www.scientificamerican.com/article/could-mitochondria-be-the-key-to-a-healthy-brain/
But another way mitochondria could contribute to brain disorders stems from ... Eliminating the elements of the immune system activated by ...
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https://www.scientificamerican.com/article/could-mitochondria-be-the-key-to-a-healthy-brain/
But another way mitochondria could contribute to brain disorders stems from ... Eliminating the elements of the immune system activated by ...
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63
Brain and Body: Mitochondria! Disease, Fever, and Impulsivity
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/3FFAA765A1E9483F5D0F5865E9808D9D/S1092852900015261a.pdf/brain-and-body-mitochondrial-disease-fever-and-impulsivity.pdf
immune system, peripheral nervous system, ... in brain function can have powerful effects on somatic function. ... comorbidity in mitochondrial disease.
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https://www.cambridge.org/core/services/aop-cambridge-core/content/view/3FFAA765A1E9483F5D0F5865E9808D9D/S1092852900015261a.pdf/brain-and-body-mitochondrial-disease-fever-and-impulsivity.pdf
immune system, peripheral nervous system, ... in brain function can have powerful effects on somatic function. ... comorbidity in mitochondrial disease.
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64
Immune Functions of Mitochondrial Metabolism – Rare Diseases
https://mrgm.fr/ifmm/
Because they express a variety of innate immune receptors, cells of the innate immune system such as macrophages or dendritic cells represent the first ...
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https://mrgm.fr/ifmm/
Because they express a variety of innate immune receptors, cells of the innate immune system such as macrophages or dendritic cells represent the first ...
→ Check Latest Keyword Rankings ←
65
Types of Mitochondrial Myopathies (MM) - Diseases
https://www.mda.org/disease/mitochondrial-myopathies/types
Together, Leigh syndrome and MELAS are the most common mitochondrial myopathies. ... neutropenia (low level of immune cells, called neutrophils), ...
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https://www.mda.org/disease/mitochondrial-myopathies/types
Together, Leigh syndrome and MELAS are the most common mitochondrial myopathies. ... neutropenia (low level of immune cells, called neutrophils), ...
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66
Mitochondrial dysfunction in the pathophysiology of renal ...
https://journals.physiology.org/doi/10.1152/ajprenal.00571.2013
Next, acquired mitochondrial dysfunction in kidney diseases is discussed, ... (161) believe that it is the immune system involved in mitochondrial signaling ...
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https://journals.physiology.org/doi/10.1152/ajprenal.00571.2013
Next, acquired mitochondrial dysfunction in kidney diseases is discussed, ... (161) believe that it is the immune system involved in mitochondrial signaling ...
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67
Our white blood cells like premium fuel better
https://www.timeshighereducation.com/hub/p/our-white-blood-cells-premium-fuel-better
White blood cells, or leukocytes, are part of the immune system, ... experience in studying mitochondrial dysfunction mechanisms in cardiovascular disease.
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https://www.timeshighereducation.com/hub/p/our-white-blood-cells-premium-fuel-better
White blood cells, or leukocytes, are part of the immune system, ... experience in studying mitochondrial dysfunction mechanisms in cardiovascular disease.
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68
The emerging role of immune dysfunction in mitochondrial ...
https://www.metabolismjournal.com/article/S0026-0495(17)30322-0/pdf
This may explain why none of the reviews and textbooks on MDs include a section on the immune system. 4. Mouse Models of Mitochondrial Disease ...
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https://www.metabolismjournal.com/article/S0026-0495(17)30322-0/pdf
This may explain why none of the reviews and textbooks on MDs include a section on the immune system. 4. Mouse Models of Mitochondrial Disease ...
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69
Plasma mitochondrial DNA is associated with extrapulmonary ...
https://erj.ersjournals.com/content/54/2/1801762
Sarcoidosis is an unpredictable granulomatous disease in which African Americans ... Mitochondrial DNA (mtDNA) released by cells in response to various ...
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https://erj.ersjournals.com/content/54/2/1801762
Sarcoidosis is an unpredictable granulomatous disease in which African Americans ... Mitochondrial DNA (mtDNA) released by cells in response to various ...
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70
Mitochondrial Disorder | Center for Rare Disease Therapy
https://www.chp.edu/our-services/rare-disease-therapy/conditions-we-treat/mitochondrial-disorder
When the mitochondria are faulty and can't do their job, many organs and systems of the body begin to fail. Children with mitochondrial disorders can suffer ...
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https://www.chp.edu/our-services/rare-disease-therapy/conditions-we-treat/mitochondrial-disorder
When the mitochondria are faulty and can't do their job, many organs and systems of the body begin to fail. Children with mitochondrial disorders can suffer ...
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71
Single-cell analysis provides new insights into mitochondrial ...
https://www.massgeneral.org/news/press-release/Single-cell-analysis-provides-new-insights-into-mitochondrial-diseases
Mitochondrial diseases result from failure of mitochondria, ... in heteroplasmy across immune cell types affect the cells' function, ...
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https://www.massgeneral.org/news/press-release/Single-cell-analysis-provides-new-insights-into-mitochondrial-diseases
Mitochondrial diseases result from failure of mitochondria, ... in heteroplasmy across immune cell types affect the cells' function, ...
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72
Disruption of innate immunity due to mitochondrial targeting of ...
https://www.pnas.org/doi/10.1073/pnas.0611506104
Mitochondrial antiviral signaling protein (MAVS) is an essential component of ... The IFN-β response to overexpression of MAVS was also reduced, ...
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https://www.pnas.org/doi/10.1073/pnas.0611506104
Mitochondrial antiviral signaling protein (MAVS) is an essential component of ... The IFN-β response to overexpression of MAVS was also reduced, ...
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73
Mitochondrial Dysfunction May Be to Blame in Long COVID-19
https://www.everydayhealth.com/coronavirus/mitochondrial-dysfunction-may-be-to-blame-in-long-covid-19/
“This could be caused by the immune system response to COVID-19, ... but for many other disease processes where the mitochondria may not ...
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https://www.everydayhealth.com/coronavirus/mitochondrial-dysfunction-may-be-to-blame-in-long-covid-19/
“This could be caused by the immune system response to COVID-19, ... but for many other disease processes where the mitochondria may not ...
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74
Unlocking hidden connections between cell dea - EurekAlert!
https://www.eurekalert.org/news-releases/970104
... mitochondria influences chronic inflammatory disorders and immune ... Figuring out how mitochondrial mutations disturb immune response ...
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https://www.eurekalert.org/news-releases/970104
... mitochondria influences chronic inflammatory disorders and immune ... Figuring out how mitochondrial mutations disturb immune response ...
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75
Expanding and validating the biomarkers for mitochondrial ...
https://link.springer.com/article/10.1007/s00109-020-01967-y
Mitochondrial diseases are highly heterogeneous metabolic ... link between the brain and immune system in neuro-immunological disorders.
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https://link.springer.com/article/10.1007/s00109-020-01967-y
Mitochondrial diseases are highly heterogeneous metabolic ... link between the brain and immune system in neuro-immunological disorders.
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76
Mitochondrial trifunctional protein deficiency - Genetics
https://medlineplus.gov/genetics/condition/mitochondrial-trifunctional-protein-deficiency/
Infants with this disorder are also at high risk for serious heart problems, breathing difficulties, coma, and sudden death. Signs and symptoms of mitochondrial ...
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https://medlineplus.gov/genetics/condition/mitochondrial-trifunctional-protein-deficiency/
Infants with this disorder are also at high risk for serious heart problems, breathing difficulties, coma, and sudden death. Signs and symptoms of mitochondrial ...
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77
Can we alter dietary macronutrient compositions and alleviate ...
https://www.rarediseasesjournal.com/articles/can-we-alter-dietary-macronutrient-compositions-and-alleviate-mitochondrial-disease.html
Mitochondrial density contributes to the immune response of macrophages to lipopolysaccharide via the MAPK pathway. FEBS Lett. 2011;585(14):2263 ...
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https://www.rarediseasesjournal.com/articles/can-we-alter-dietary-macronutrient-compositions-and-alleviate-mitochondrial-disease.html
Mitochondrial density contributes to the immune response of macrophages to lipopolysaccharide via the MAPK pathway. FEBS Lett. 2011;585(14):2263 ...
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78
Mitochondrial Disease & Immune Systems - SlideShare
https://www.slideshare.net/mitoaction/mitochondrial-disease-immune-systems
Metabolism, Infection and Immunity in Mitochondrial Disease Peter J. McGuire MS, MD Head, MINI Section National Human Genome Research ...
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https://www.slideshare.net/mitoaction/mitochondrial-disease-immune-systems
Metabolism, Infection and Immunity in Mitochondrial Disease Peter J. McGuire MS, MD Head, MINI Section National Human Genome Research ...
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79
Mitochondrial diseases - Cancer Therapy Advisor
https://www.cancertherapyadvisor.com/home/decision-support-in-medicine/pediatrics/mitochondrial-diseases/
Are you sure your patient has a Mitochondrial disease? ... Variable clinical findings involving skeletal muscle, heart, and immune system.
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https://www.cancertherapyadvisor.com/home/decision-support-in-medicine/pediatrics/mitochondrial-diseases/
Are you sure your patient has a Mitochondrial disease? ... Variable clinical findings involving skeletal muscle, heart, and immune system.
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80
How Might Mitochondrial Disease Affect My Lifespan?
https://mitochondrialdiseasenews.com/2020/04/27/how-might-mitochondrial-disease-affect-my-lifespan/
The researchers indicated that boosting the immune system of children with mitochondrial disease may be key to increasing their lifespan.
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https://mitochondrialdiseasenews.com/2020/04/27/how-might-mitochondrial-disease-affect-my-lifespan/
The researchers indicated that boosting the immune system of children with mitochondrial disease may be key to increasing their lifespan.
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81
Mitochondrial Disease: The Tiring Disease You May Have
https://draxe.com/health/mitochondrial-disease/
I'm talking about mitochondrial disease. ... Stress worsens inflammation and fatigue while also hindering immune function.
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https://draxe.com/health/mitochondrial-disease/
I'm talking about mitochondrial disease. ... Stress worsens inflammation and fatigue while also hindering immune function.
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82
Modulation by Coriolus Versicolor (Yun-Zhi) Nutritional ...
https://www.jneurology.com/articles/pneuroinflammation-and-mitochondrial-dysfunction-in-the-pathogenesis-of-alzheimerrsquos-disease-modulation-by-coriolus-versicolor-.html
Alzheimer's disease (AD) affecting more than 45 million people worldwide is a ... Indeed, the effects of polysaccharides on the immune system are by far the ...
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https://www.jneurology.com/articles/pneuroinflammation-and-mitochondrial-dysfunction-in-the-pathogenesis-of-alzheimerrsquos-disease-modulation-by-coriolus-versicolor-.html
Alzheimer's disease (AD) affecting more than 45 million people worldwide is a ... Indeed, the effects of polysaccharides on the immune system are by far the ...
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83
Metabolic and Immune Responses to Flu Vaccine ... - Grantome
https://grantome.com/grant/NIH/R21-HD061709-01A1
However, little is known about the clinical and immune response to vaccines in patients with mitochondrial disorders. Mitochondria play an important role in ...
→ Check Latest Keyword Rankings ←
https://grantome.com/grant/NIH/R21-HD061709-01A1
However, little is known about the clinical and immune response to vaccines in patients with mitochondrial disorders. Mitochondria play an important role in ...
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84
Mitochondrial Function, Biology, and Role in Disease
https://www.ahajournals.org/doi/10.1161/res.0000000000000104
In this section, we will focus on the role of mitochondria in inflammation. The immune system is activated not only by microorganism ...
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https://www.ahajournals.org/doi/10.1161/res.0000000000000104
In this section, we will focus on the role of mitochondria in inflammation. The immune system is activated not only by microorganism ...
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85
Mitochondrial disease - Wikipedia
https://en.wikipedia.org/wiki/Mitochondrial_disease
Mitochondrial disease is a group of disorders caused by mitochondrial dysfunction. Mitochondria are the organelles that generate energy for the cell and are ...
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https://en.wikipedia.org/wiki/Mitochondrial_disease
Mitochondrial disease is a group of disorders caused by mitochondrial dysfunction. Mitochondria are the organelles that generate energy for the cell and are ...
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86
What You Should Know About Flu Antiviral Drugs - CDC
https://www.cdc.gov/flu/treatment/whatyoushould.htm
People with a weakened immune system due to disease (such as people with HIV or AIDS, or some cancers such as leukemia) or medications (such ...
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https://www.cdc.gov/flu/treatment/whatyoushould.htm
People with a weakened immune system due to disease (such as people with HIV or AIDS, or some cancers such as leukemia) or medications (such ...
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87
Who is at increased risk from COVID-19? - NHS England
https://www.england.nhs.uk/who-is-at-increased-risk-from-covid-19/
a long-term lung condition, such as chronic obstructive pulmonary disease (COPD), ... hormone disorder, such as Addison's disease; a weakened immune system, ...
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https://www.england.nhs.uk/who-is-at-increased-risk-from-covid-19/
a long-term lung condition, such as chronic obstructive pulmonary disease (COPD), ... hormone disorder, such as Addison's disease; a weakened immune system, ...
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88
Mitochondria: The Key To Unlocking A Healthier Body
https://health.economictimes.indiatimes.com/news/diagnostics/mitochondria-the-key-to-unlocking-a-healthier-body/95801206
These factors can also lead to mitochondrial dysfunction—a condition ... muscle contraction, protecting the DNA, immune system functioning, ...
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https://health.economictimes.indiatimes.com/news/diagnostics/mitochondria-the-key-to-unlocking-a-healthier-body/95801206
These factors can also lead to mitochondrial dysfunction—a condition ... muscle contraction, protecting the DNA, immune system functioning, ...
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89
New evidence on the links between immune activation and ...
https://www.news-medical.net/news/20221201/New-evidence-on-the-links-between-immune-activation-and-neuroinflammation-and-Parkinsons-disease.aspx
... to the Journal of Parkinson's Disease, "The Immune System in Parkinson's Disease ... to mitochondrial antigens in PD," noted Dr. Sulzer.
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https://www.news-medical.net/news/20221201/New-evidence-on-the-links-between-immune-activation-and-neuroinflammation-and-Parkinsons-disease.aspx
... to the Journal of Parkinson's Disease, "The Immune System in Parkinson's Disease ... to mitochondrial antigens in PD," noted Dr. Sulzer.
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90
Episode #112: The Connection Between Cell Danger ...
https://biohackingsuperhumanperformance.libsyn.com/episode-112-the-connection-between-cell-danger-response-mitochondrial-dysfunction
What is cell danger response, mitochondria dysfunction, what supplementation and ... helps the immune system to rejuvenate and it protects DNA.
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https://biohackingsuperhumanperformance.libsyn.com/episode-112-the-connection-between-cell-danger-response-mitochondrial-dysfunction
What is cell danger response, mitochondria dysfunction, what supplementation and ... helps the immune system to rejuvenate and it protects DNA.
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91
The Human Protein Atlas
https://www.proteinatlas.org/
Biological process, Molecular function, Disease ... 64:Astrocytes - Nervous system maintenance, 57:B-cells - Immune response, 56:Bipolar cells - Visual ...
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https://www.proteinatlas.org/
Biological process, Molecular function, Disease ... 64:Astrocytes - Nervous system maintenance, 57:B-cells - Immune response, 56:Bipolar cells - Visual ...
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92
Potential Modifier Gene Therapy for Degenerative Retinal ...
https://www.fiercebiotech.com/sponsored/potential-modifier-gene-therapy-degenerative-retinal-diseases
Although rare diseases are individually rare, around the globe nearly 400 ... to activate both B- and T-cell arms of the immune system.
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https://www.fiercebiotech.com/sponsored/potential-modifier-gene-therapy-degenerative-retinal-diseases
Although rare diseases are individually rare, around the globe nearly 400 ... to activate both B- and T-cell arms of the immune system.
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93
9 Benefits of Coenzyme Q10 (CoQ10) - Healthline
https://www.healthline.com/nutrition/coenzyme-q10
The mitochondria are in charge of producing energy. They also protect cells from oxidative damage and disease-causing bacteria or viruses ...
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https://www.healthline.com/nutrition/coenzyme-q10
The mitochondria are in charge of producing energy. They also protect cells from oxidative damage and disease-causing bacteria or viruses ...
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94
Mitochondrial Diseases - Page 146 - Google Books Result
https://books.google.com/books?id=GReQDwAAQBAJ&pg=PA146&lpg=PA146&dq=mitochondrial+disease+immune+system&source=bl&ots=U2aF9-rScW&sig=ACfU3U0PpyGeGcW7tyMZU8mZG9vxGp7nnA&hl=en&sa=X&ved=2ahUKEwif5K-ExOP7AhX8-XMBHUgwCeoQ6AF6BQjfAhAD
Immune response in Parkinson's disease Despite PD is characterized by a slow and progressive degeneration of dopaminergic neurons in the SNpc, ...
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https://books.google.com/books?id=GReQDwAAQBAJ&pg=PA146&lpg=PA146&dq=mitochondrial+disease+immune+system&source=bl&ots=U2aF9-rScW&sig=ACfU3U0PpyGeGcW7tyMZU8mZG9vxGp7nnA&hl=en&sa=X&ved=2ahUKEwif5K-ExOP7AhX8-XMBHUgwCeoQ6AF6BQjfAhAD
Immune response in Parkinson's disease Despite PD is characterized by a slow and progressive degeneration of dopaminergic neurons in the SNpc, ...
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