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1 HDAC Inhibition Attenuates Inflammatory, Hypertrophic and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931819/
This study was established to assess the role of HDAC blockade on the inflammatory response and its effect on the pathogenesis of hypertension. Therefore, we ...
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2 Inhibition of HDACs (Histone Deacetylases) Ameliorates High ...
https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.121.17149
Inhibition of histone deacetylases restores MsrA expression, H2S production, and ameliorates high-fat diet–induced hypertension, presenting HDAC ...
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3 Selective inhibition of histone deacetylase 8 improves ...
https://clinicalhypertension.biomedcentral.com/articles/10.1186/s40885-019-0118-8
The HDAC8-selective inhibitor contributed to blood pressure reduction by inhibiting a component of the RAS or regulating NO signaling pathways.
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4 Zinc-dependent histone deacetylases: Potential therapeutic ...
https://www.sciencedirect.com/science/article/abs/pii/S0006295222002052
Fig. 2. Synthetic and dietary histone deacetylase (HDAC) inhibitors decrease blood pressure by downregulating the angiotensin converting enzyme 1 (ACE1)- ...
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5 Class I histone deacetylase inhibitor MS-275 attenuates ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213186
Objective Non-selective histone deacetylase (HDAC) inhibitors are known to improve hypertension. Here, we investigated the therapeutic ...
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6 HDAC6: A Novel Histone Deacetylase Implicated in ... - Nature
https://www.nature.com/articles/s41598-017-04874-4
Pharmacological modulation of class I histone deacetylases (HDAC) has been evaluated as a therapeutic strategy for pulmonary hypertension ...
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7 Histone deacetylase inhibitor CG200745 ... - Springer Link
https://link.springer.com/article/10.1007/s00210-019-01749-5
Obesity is one of the major risk factors of hypertension. ... HFD group showed higher body weight, blood pressure (BP), HDAC activities, ...
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8 Histone deacetylase inhibitor LMK235 attenuates vascular ...
https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14188
Abstract Here, we report that LMK235, a class I and histone deacetylase (HDAC6)-preferential HDAC inhibitor, reduces hypertension via ...
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9 Inhibtion of histone deacetylase activity reduces pulmonary ...
https://openres.ersjournals.com/content/8/suppl_8/259
Rationale: Histone deacetylases (HDACs) expression and activity are increased in pulmonary arterial hypertension (PAH). Although inhibition of HDACs has been ...
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10 Food Bioactive HDAC Inhibitors in the Epigenetic Regulation ...
https://www.mdpi.com/2072-6643/10/8/1120
Multiple stressors including hypertension and inflammation stimulate the heart to undergo remodeling. Cardiac remodeling is characterized by heart ...
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11 Histone deacetylase inhibitors for cardiovascular conditions ...
https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00061-1/fulltext
These data indicate that valproic acid might reduce blood pressure through epigenetic regulation. Pulmonary hypertension and chronic pulmonary ...
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12 Brief Report: Case Comparison of Therapy With the Histone ...
https://www.frontiersin.org/articles/10.3389/fphys.2021.712583/full
Pulmonary hypertension (PH) is an incurable condition in humans; ... Treatment with the class I/II HDAC inhibitors vorinostat or apicidin ...
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13 Emerging Roles for Histone Deacetylases in Pulmonary ...
https://journals.sagepub.com/doi/10.1086/679700
Histone deacetylase (HDAC) isoforms and sensitivity to inhibitors used in preclinical models of pulmonary hypertension and right ventricular ...
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14 HDAC Inhibition Suppresses Cardiac Hypertrophy and ...
https://www.karger.com/Article/Fulltext/350148
Results: Here we report that sodium valproate inhibits the cardiac hypertrophy accompanied by fibrosis in the heart of chronic hypertensive rats ...
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15 Histone deacetylase (HDAC) inhibitors attenuate cardiac ...
https://www.pnas.org/doi/abs/10.1073/pnas.1015081108
ZV Wang, BA Rothermel, JA Hill, Autophagy in hypertensive heart disease. J Biol Chem 285, 8509–8514 (2010). ... JA Hill, et al., Cardiac hypertrophy is not a ...
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16 PS 10-13 HISTONE DEACETYLASE INHIBITION ...
https://journals.lww.com/jhypertension/abstract/2016/09001/ps_10_13_histone_deacetylase_inhibition.945.aspx
Journal of Hypertension: September 2016 - Volume 34 - Issue - p e328 ... Histone deacetylase (HDAC) inhibitors have been emerged as new pharmacological ...
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17 HDAC Inhibitor Emodin Blocks Hypertension-Induced Cardiac ...
https://academic.oup.com/cdn/article/4/Supplement_2/396/5844333
Recently, we showed that emodin, an anthraquinone, attenuated pathological cardiac hypertrophy and histone deacetylase (HDAC) activity.
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18 Histone Deacetylase Inhibition Attenuates Aortic Remodeling ...
https://www.hindawi.com/journals/bmri/2020/4705615/
The use of histone deacetylase (HDAC) inhibitor is a novel therapeutic strategy for ... remodeling in pressure overload-induced hypertension-related diseases.
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19 GW29-e0370 Histone deacetylase inhibition ameliorates ...
https://www.jacc.org/doi/10.1016/j.jacc.2018.08.442
Cushing's syndrome (CS) caused by hypercortisolism is occasionally accompanied by metabolic disorders such as hypertension, diabetes mellitus ( ...
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20 Acetylation Preserves Retinal Ganglion Cell Structure ... - IOVS
https://iovs.arvojournals.org/article.aspx?articleid=2265999
In ocular-hypertensive eyes, class I HDAC activity was significantly ... hypertension alters retinal HDAC activity and protein acetylation and how the ...
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21 Pharmacological Effect of Histone Deacetylase Inhibitors on ...
https://spiral.imperial.ac.uk/handle/10044/1/17770
Pulmonary hypertension (PH) is characterized by structural remodelling of pulmonary arteries and arterioles, the result, at least in part, of excessive cell ...
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22 Fluid-electrolyte homeostasis requires histone deacetylase ...
https://insight.jci.org/articles/view/137792
Kidney medulla-specific inhibition of class I HDACs in the rat during high-salt feeding results in hypertension, polyuria, hypokalemia, ...
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23 Histone deacetylase inhibition with trichostatin A does not ...
https://pvrinstitute.org/en/pc-journal/explore-the-journal/pulmonary-circulation-vol-4-no-2/histone-deacetylase-inhibition-with-trichostatin-a-does-not-reverse-severe-angioproliferative-pulmonary-hypertension-in-rats-2013-grover-conference-series/
Pulmonary arterial hypertension (PAH) is a rapidly progressive and devastating disease characterized by remodeling of lung vessels, increased pulmonary ...
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24 HDAC inhibition: A novel therapeutic target for pulmonary ...
https://www.internationaljournalofcardiology.com/article/S0167-5273(15)01274-7/fulltext
Histone deacetylases(HDACs) · Pulmonary hypertension ... concerning “HDAC inhibition and myocardial ischemia/reperfusion injury”, ...
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25 Histone Deacetylase Inhibition Attenuates Transcriptional ...
https://www.semanticscholar.org/paper/Histone-Deacetylase-Inhibition-Attenuates-Activity-Lee-Lee/a5200dbfd78263efa16e016870ff5f9a31d357d7
Rationale: Inhibition of histone deacetylases (HDACs) results in attenuated development of hypertension in deoxycorticosterone ...
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26 Histone Deacetylase Inhibition in Cardiovascular Diseases
https://www.circulation.or.kr/workshop/2017spring/file/program_file2/22_45.pdf
Many HDAC inhibitors are of natural origin. Page 12. Gallic acid reduces elevated blood pressure in. NAME-induced hypertensive mice ...
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27 D97. PULMONARY HYPERTENSION - ATS Journals
https://www.atsjournals.org/doi/pdf/10.1164/ajrccm-conference.2012.185.1_MeetingAbstracts.A6516
D97 PULMONARY HYPERTENSION: NEW INSIGHTS INTO CAUSES AND TREATMENTS? ... Methods: HDAC expression was examined in lungs from idiopathic PAH patients and ...
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28 Critical Functions of Histone Deacetylases (HDACs) in ... - MDPI
https://mdpi-res.com/d_attachment/pathophysiology/pathophysiology-29-00038/article_deploy/pathophysiology-29-00038-v2.pdf?version=1661223666
HDAC activity and histone hypoacetylation are associated with the ... the control of hypertension and resultant cardiac hypertrophy.
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29 Expression of Class I and Class II a/b Histone Deacetylase is ...
https://e-kcj.org/DOIx.php?id=10.4070/kcj.2016.0266
Similar increases in systolic blood pressure were observed in angiotensin II or L-NAME-induced hypertensive mice. In SHR, class IIa HDAC (HDAC4, ...
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30 Histone Deacetylase Inhibition Attenuates ... - ResearchGate
https://www.researchgate.net/publication/235668432_Histone_Deacetylase_Inhibition_Attenuates_Transcriptional_Activity_of_Mineralocorticoid_Receptor_Through_Its_Acetylation_and_Prevents_Development_of_Hypertension
Emerging evidence demonstrates that inhibition of histone deacetylase (HDACi) ameliorates hypertension in several hypertensive animal models ...
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31 Cardiac HDAC6 catalytic activity is induced in response to ...
https://www.genscript.com/reference_peer-reviewed_literature_6867.html
Synthetic HDAC substrates: class I HDAC substrate (custom synthesis by Genscript) ... Histone deacetylase; Hypertension; Heart failure; Cardiac hypertrophy; ...
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32 Histone Deacetylase Inhibition Attenuates Cardiac ...
https://molpharm.aspetjournals.org/content/87/5/782
Other groups also have reported that HDAC inhibitor can prevent cardiac hypertrophy and fibrosis in animal models of hypertension, ...
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33 Histone deacetylase inhibitor, mocetinostat, regulates cardiac ...
https://www.imrpress.com/journal/RCM/22/3/10.31083/j.rcm2203113/htm
Histone deacetylase. Hypertension. Hypertrophy. Kidney. 1. Introduction. Hypertension (HTN) is a major modifiable risk factor for cardiovascular disease.
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34 Histone Deacetylase Inhibition has Cardiac and Vascular ...
https://www.biomed.cas.cz/physiolres/pdf/2019/68_727.pdf
Histone deacetylase (HDAC) inhibitors have shown beneficial effects in animal models of ... hypertrophy and fibrosis in DOCA-salt hypertensive rats.
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35 Therapeutic Potential for Natural Product HDAC Inhibitors in ...
https://norcaloa.com/JPCT/articles-in-press/JPCT-101011
Keywords: Acetylation; Bioactive compounds; Dietary HDAC Inhibitors HDACs; ... In response to stress, such as hypertension, the myocardium undergoes ...
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36 Autophagy in Metabolic Distress and Cardiac Function
https://grantome.com/grant/NIH/K08-HL116801-02
HDAC inhibitors could target both maladaptive autophagy in hypertension and ameliorate metabolic stresses in diabetes. These agents can potentially turn into ...
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37 Research progress on the effect of histone deacetylase on ...
http://www.plamj.org/index.php/plamj/article/view/2611
Pulmonary arterial hypertension (PAH) is a progressive disease with poor prognosis, which may lead to right heart dysfunction, resulting in a series of ...
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38 Fluid-electrolyte homeostasis requires ... - Scholars@UAB
http://scholars.uab.edu/display/pub2340345
Histone deacetylase (HDAC) enzymes regulate transcription through ... of class I HDACs in the rat during high-salt feeding results in hypertension, ...
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39 Cardiac hypertrophy | Department of Medicine
https://www.medicine.uci.edu/news-releases/levin-Cardiac_hypertrophy.asp
Despite years of testing HDAC inhibitors in humans to prevent cardiac disease, ... angiotensin-induced hypertension, cardiac hypertrophy and fibrosis, ...
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40 Therapeutic for Pulmonary Arterial Hypertension | Yale Ventures
https://ventures.yale.edu/node/153
HDAC Inhibitors for Treatment of PAH. Pulmonary arterial hypertension (PAH) has limited treatment options with 40-50% mortality within 3 years of diagnosis.
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41 Three 4-letter words of hypertension-related cardiac hypertrophy
https://www.jmcc-online.com/article/S0022-2828(11)00065-4/fulltext
Left ventricular hypertrophy due to hypertension represents a major ... Recent studies on TRPC channels, mTOR, and HDAC enzymes provide new ...
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42 Targeting histone acetylation in pulmonary hypertension and ...
https://www.x-mol.com/paper/oa/url?paperId=1213063915080192013&host=doi.org&type=HTML
Pulmonary arterial hypertension (PAH) is a rapidly progressive vascular disease with ... HDAC inhibition attenuated hypoxia-induced PH.
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43 HDAC Inhibition Suppresses Cardiac ... - CyberLeninka
https://cyberleninka.org/article/n/254994.pdf
HDAC Inhibition Suppresses Cardiac. Hypertrophy and Fibrosis in DOCA-Salt. Hypertensive Rats via Regulation of. HDAC6/HDAC8 Enzyme Activity. Hae Jin Keea.
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44 DPP (dipeptidyl peptidase)-4 inhibitor attenuates ANG II ...
https://kyushu-u.pure.elsevier.com/en/publications/dpp-dipeptidyl-peptidase-4-inhibitor-attenuates-ang-ii-angiotensi
... phosphate oxidase) 4-HDAC (histone deacetylase) 4 pathway ... changing aortic blood pressure or metabolic parameters such as blood ...
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45 COVID-19 Therapeutics - Uniurb it
https://ora.uniurb.it/retrieve/handle/11576/2681675/129511/fphar-11-582003%20HDAC%20Covid.pdf
Keywords: COVID-19, SARS-CoV-2, HDAC, hypertension, ACE2, off-label drugs. INTRODUCTION. The Coronavirus superfamily includes several human ...
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46 Histone deacetylase inhibitor CG200745 ameliorates high-fat ...
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/43251
Histone deacetylase inhibitor CG200745 ameliorates high-fat diet-induced hypertension via inhibition of angiotensin II production. Metadata Downloads.
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47 Hypertension - OBESITY - Ingenta Connect
https://www.ingentaconnect.com/content/wk/hyp/2021/00000078/00000004/art00021?crawler=true&mimetype=application/pdf
relevance of MsrA in high-fat diet (HFD)-induced hypertension and the effect of HDAC inhibition on MsrA expression, H2S production, and hypertension.
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48 Acetyl-lysine erasers and readers in the control of pulmonary ...
https://cdnsciencepub.com/doi/pdf/10.1139/bcb-2014-0119
Key words: epigenetics, RV hypertrophy, pulmonary hypertension, HDAC, bromodomain. Résumé : L'acétylation des lysines situées a` l'intérieur des queues des ...
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49 Combined Inhibition of Histone Deacetylases and ... - CCTSI
https://cctsi.cuanschutz.edu/docs/librariesprovider28/2022-pediatric-posters/june/hui-zhang.pdf?sfvrsn=98de95ba_2
HDAC inhibitors (HDACi) or BRD inhibitors (BRDi) can prevent and ameliorate pulmonary hypertensive changes in vitro and in vivo by normalizing.
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50 Discovery of Novel Class I Histone Deacetylase Inhibitors with ...
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5b01044
Dissecting Histone Deacetylase 3 in Multiple Disease Conditions: ... Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.
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51 Hypertension: New Insights for the Healthcare Professional: ...
https://books.google.com/books?id=WRy4PH14bpwC&pg=PA245&lpg=PA245&dq=hdac+hypertension&source=bl&ots=BjPM9B1KPV&sig=ACfU3U0YJosoBglpA9cokbfobVTqe2LRMQ&hl=en&sa=X&ved=2ahUKEwjGkIjGneX7AhUXnXIEHXQZB40Q6AF6BQjuARAD
We developed assays to quantify catalytic activity of distinct HDAC classes in left and right ventricular cardiac tissue from animal models of hypertensive ...
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52 Safety Study of the Histone Deacetylase Inhibitor, CHR-3996 ...
https://clinicaltrials.gov/ct2/show/NCT00697879
Safety Study of the Histone Deacetylase Inhibitor, CHR-3996, ... Uncontrolled hypertension; A history of QTc abnormalities or with a mean QTc interval >450 ...
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53 Pulmonary Hypertension: Basic Science to Clinical Medicine
https://books.google.com/books?id=D73fCgAAQBAJ&pg=PA95&lpg=PA95&dq=hdac+hypertension&source=bl&ots=QU-wwV_Hor&sig=ACfU3U3F18IazXAkVQxkoRFM4N4_6cSuVQ&hl=en&sa=X&ved=2ahUKEwjGkIjGneX7AhUXnXIEHXQZB40Q6AF6BQjtARAD
Studies in cells derived from the hypertensive pulmonary circulation of all three species have demonstrated that HDAC inhibition results in a decrease in ...
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54 HDAC6: A Novel Histone Deacetylase Implicated in ...
https://www.sigmaaldrich.com/AU/en/tech-docs/paper/953541
HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension. by Olivier Boucherat, Sophie Chabot, Roxane Paulin, ...
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55 HDAC6 regulates microtubule stability and clustering of ...
https://rupress.org/jcb/article/219/8/e201901099/151966/HDAC6-regulates-microtubule-stability-and
As a member of class IIb of the HDAC family, HDAC6 contains five ... Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension.
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56 Histone deacetylatse (HDAC) inhibitors - YouTube
https://www.youtube.com/watch?v=OBcpk-M5RYE
 in this video
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57 SABCS - San Antonio Breast Cancer Symposium
https://www.medpagetoday.com/meetingcoverage/sabcs
... and Management of Resistant Hypertension Among High-Risk Populations ... Small PFS Boost With HDAC Inhibitor for Advanced HR-Positive Breast Cancer.
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58 Blood pressure medicine recalled due to potential cancer risk
https://www.usatoday.com/story/news/health/2022/10/27/blood-pressure-medicine-recal-cancer-risk-fda/10613436002/
The tablets are commonly prescribed for the treatment of hypertension to lower blood pressure. Low levels of nitrosamine, or N-nitroso-quinapril ...
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59 Cereno Scientific rapporterar sex aktiverade studiekliniker och ...
https://news.cision.com/se/cereno-scientific/r/cereno-scientific-rapporterar-sex-aktiverade-studiekliniker-och-uppdaterar-tidslinjen-for-fas-ii-stu,c3676616
... i pulmonell arteriell hypertension (PAH) med läkemedelskandidaten CS1. ... CS1 är en HDAC-hämmare (histondeacetylas) som verkar som en ...
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60 连环蛋白1(CTNNB1)基因- Gene - MCE
https://www.medchemexpress.cn/gene/1499.html
... Early 2 Factor (E2F) · Eukaryotic Initiation Factor (eIF) · G-quadruplex · Haspin Kinase · HDAC ... Hypertension, Essential. Essential Hypertension.
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61 Episode 440 - Q&A with Robb & Nicki #33 - RobbWolf.com
https://robbwolf.com/2019/09/13/episode-440-qa-with-robb-nicki-33/
... if it's some HDAC inhibition due to ketone bodies, but they have ... Robb: So, if you have high blood pressure and high cholesterol, ...
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62 Histone deacetylase inhibitors (HDACIs) - Dove Medical Press
https://www.dovepress.com/histone-deacetylase-inhibitors-hdacis-multitargeted-anticancer-agents-peer-reviewed-fulltext-article-BTT
Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents Katherine Ververis,1 Alison Hiong,1 Tom C Karagiannis,1,* Paul V ...
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63 Lancet Paper Shows Most Popular Hypertension Drug Isn't ...
https://www.dbmi.columbia.edu/lancet-legend-hypertension-study/
› lancet-legend-hypert...
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64 Histone Deacetylase Inhibition and Cancer Therapy. - LinkedIn
https://www.linkedin.com/pulse/histone-deacetylase-inhibition-cancer-therapy-gururaj-m-shivashimpi
Therefore, today HDACs are potential targets and identification of potent HDAC inhibitors possessing adequate 'drug like' properties is a ...
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65 Popular Blood Pressure Medication Recalled Over Cancer ...
https://www.prevention.com/health/a39538283/pfizer-blood-pressure-medication-recall-carcinogen-march-2022/
If you take medication for high blood pressure, you may want to double-check its label. Pfizer just issued a voluntary recall of its popular ...
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66 Lupin recalls hypertension drugs for cancer-causing element
https://www.miamiherald.com/news/recalls/article255058982.html
Lupin said it discontinued marketing the tablets, used to treat hypertension (high blood pressure), in January. Here's what you need to know.
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