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1 The Challenging Landscape of Cancer and Aging - NCI
https://www.cancer.gov/news-events/cancer-currents-blog/2018/sharpless-aging-cancer-research
Aging is a Risk Factor for Cancer ... Age is a well-recognized risk factor for cancer development. In fact, you could say aging is the major ...
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2 Aging and Cancer - Wiley Online Library
https://onlinelibrary.wiley.com/journal/26438909
Aging AND Cancer is a quarterly peer-reviewed, international open access journal that is focused on understanding how the process of aging is a central ...
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3 The importance of aging in cancer research - Nature
https://www.nature.com/articles/s43587-022-00231-x
Cancer is a disease of aging, but it is rarely studied in aged animal models and older adults are often insufficiently represented in cancer ...
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4 Age-associated differences in the cancer molecular landscape
https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00135-2
Cancer is an age-related disease, as incidence and mortality for most types of cancer increase with age. However, how molecular alterations ...
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5 Age and cancer | Cancer Research UK
https://www.cancerresearchuk.org/about-cancer/causes-of-cancer/age-and-cancer
Age and cancer · Cancer can develop at any age. But as we get older, most types of cancer become more common. · This is because our cells can get ...
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6 Aging and Cancer: Issues of Basic and Clinical Science | JNCI
https://academic.oup.com/jnci/article/89/20/1489/2526449
Recent estimates from the Surveillance, Epidemiology, and End Results (SEER) Program 1 indicate that the median age of patients with cancer in the United States ...
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7 The Biology of Aging and Cancer: Frailty, Inflammation, and...
https://journals.lww.com/journalppo/fulltext/2017/07000/the_biology_of_aging_and_cancer__frailty,.2.aspx
As age is considered as a major risk factor for cancer, inflammageing is likely a strong candidate to connect age and cancer. In addition, recent ...
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8 Cancer and Ageing | UICC
https://www.uicc.org/what-we-do/thematic-areas-work/cancer-and-ageing
As populations age, their risk of developing cancer increases. Research has found that the elderly (defined as people aged 65 years and above) are 11 times more ...
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9 AACR Special Conference: Aging and Cancer
https://www.aacr.org/meeting/aacr-special-conference-aging-and-cancer/
Aging in and of itself is a major risk factor in the development of cancer. As cells age, the risk for genomic instability, DNA damage, inflammation, and ...
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10 Cancer and Aging - the Inflammatory Connection
http://www.aginganddisease.org/EN/10.14336/AD.2016.1230
Aging and cancer are highly correlated biological phenomena. Various cellular processes such as DNA damage responses and cellular senescence that serve as ...
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11 Cancer and Aging: Two Tightly Interconnected Biological ...
https://www.mdpi.com/2072-6694/13/6/1400
Age is one of the main risk factors of cancer; several biological changes linked with the aging process can explain this. As our population is progressively ...
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12 Ageing as an Important Risk Factor for Cancer
https://ar.iiarjournals.org/content/36/10/5009
It seems that the risk of developing cancer reflects the number of mitotic divisions of adult tissue stem cells (16). This hypothesis highlights the role of ...
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13 Center for Cancer and Aging - City of Hope
https://www.cityofhope.org/research/beckman-research-institute/center-for-cancer-and-aging
Approximately 60 percent of all cancers occur in people aged 65 years or older. Older adults with cancer are underrepresented in the clinical trials that shape ...
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14 Cancer Treatment as an Accelerated Aging Process
https://ascopubs.org/doi/10.1200/EDBK_156160
Together, the aging of the U.S. population and the association of cancer and aging is culminating in a 67% increase in cancer incidence in individuals age 65 or ...
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15 Are Telomeres the Key to Aging and Cancer
https://learn.genetics.utah.edu/content/basics/telomeres/
And if scientists can learn how to stop telomerase, they might be able to fight cancer by making cancer cells age and die. In one experiment, researchers ...
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16 Aging and Cancer | SpringerLink
https://link.springer.com/book/10.1007/978-3-642-82101-1
For cancer, the second leading cause of death in America, the situation is quite different; cancer is clearly a disease and is not a change expected with aging.
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17 Immunity, ageing and cancer - BioMed Central
https://immunityageing.biomedcentral.com/articles/10.1186/1742-4933-5-11
Cancer is largely a disease of older people; the median age for cancer diagnosis in industrialised countries is approaching 70 years of age and ...
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18 Cancer associated with aging
https://www.buckinstitute.org/focus-areas/cancer/
Our risk of cancer increases significantly after age 50, and half of all cancers occur at age 66 and above. Buck scientists are studying aging processes linked ...
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19 p16 a biomarker of aging and tolerance for cancer therapy
https://tcr.amegroups.com/article/view/37390/html
This aging of the population is associated with an increased cancer incidence which rises dramatically with age and suggests that between 2010 and 2030, there ...
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20 Biology of Aging and Cancer - Vladimir N. Anisimov, 2007
https://journals.sagepub.com/doi/10.1177/107327480701400104
Aging may predispose to cancer by at least two mechanisms: tissue accumulation of cells in late stages of carcinogenesis and alterations in internal homeostasis ...
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21 Hallmarks of cancer and hallmarks of aging - Aging-US
https://www.aging-us.com/article/204082/text
Oncogenic mutations make cancer cells resistant to growth-limiting conditions (a definition of oncogenic-type of resistance was discussed ...
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22 Aging & Cancer | Samuel Waxman Cancer Research ...
https://www.waxmancancer.org/key-initiatives/aging-cancer/
The SWCRF launched the Partnership for Aging and Cancer Research Program to fund research that studies the genetic and environmental factors that make ...
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23 Cancer and Aging - Cancer Today
https://www.cancertodaymag.org/fall-2022/cancer-and-aging/
Cancer cells exploit an aging “infrastructure” to threaten life in those 60 and older. ... PRESIDENT JOE BIDEN SIGNED INTO LAW the Infrastructure ...
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24 Stem Cell Aging and Cancer - Science
https://www.science.org/doi/10.1126/sageke.2006.9.pe12
These observations support the hypothesis that much age-related morbidity may be caused by diminished somatic stem cell self-renewal and proliferation. In ...
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25 Epigenetics of Aging and Cancer: A Comprehensive Look
https://www.sciencedirect.com/science/article/pii/B9780128139394000371
Aging is the inevitable decline in physiological function and constitutes a major risk factor for the development of cancer.
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26 Cancer and Cell Aging - Center for Biomedical Discovery
https://www.mayo.edu/research/centers-programs/center-biomedical-discovery/platforms/cancer-cell-aging
Normal regulated cell growth is required for life, whereas cancer (neoplasia) results from uncontrolled cell growth. Researchers study the mechanisms that ...
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27 Aging, Cellular Senescence, and Cancer - Annual Reviews
https://www.annualreviews.org/doi/abs/10.1146/annurev-physiol-030212-183653
Aging, Cellular Senescence, and Cancer. Annual Review of Physiology. Vol. 75:685-705 (Volume publication date February 2013)
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28 Cancer Prevention During Older Adulthood - CDC
https://www.cdc.gov/cancer/dcpc/prevention/older-adulthood.htm
More than two-thirds of all new cancers are diagnosed among adults aged 60 years and older. As the number of adults living to older ages continues to increase, ...
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29 Finding well-being where cancer and aging meet
https://www.apa.org/monitor/2021/07/lab-cancer-aging
Age is the single most important risk factor for cancer, but older adults with cancer can be a challenging research population.
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30 Does Cancer Risk Increase with Age? - Buffalo, NY
https://www.roswellpark.org/cancertalk/202006/does-cancer-risk-increase-age
Unfortunately, yes. Age is the highest risk factor for developing a majority of cancers, with a few exceptions.
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31 Aging and Cancer - University of Colorado School of Medicine
https://medschool.cuanschutz.edu/colorado-cancer-center/community/CommunityOutreachEngagement/cancer-treatment-and-survivorship-projects/aging-and-cancer
Aging is the greatest risk factor for cancer incidence and mortality. Currently, the rapid expansion of the aged population is directly fueling ...
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32 Cancer and Aging Research Group – Improving the care of ...
https://www.mycarg.org/
Welcome to CARG! The mission of the Cancer and Aging Research Group is to join geriatric oncology researchers across the nation in a collaborative effort of ...
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33 Cancer: The aging epigenome - eLife
https://elifesciences.org/articles/78693
Cancer risk increases with age, in part, because genetic mutations that arise from DNA replication errors and exposure to environmental ...
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34 Aging and cancer: A surprising two way relationship
https://www.medicalnewstoday.com/articles/326541
A new study has shown that the relationship between aging and cancer may be more intimate and complex than previously thought.
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35 Analysis of Biological Aging and Risks of All-Cause and ...
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2793435
Cancer is an age-related disease. In the United States, the median age at cancer diagnosis is 66 years. In older people diagnosed with ...
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36 The Contribution of Physiological and Accelerated Aging to ...
https://www.frontiersin.org/articles/10.3389/fonc.2021.747822/full
Age is by far the most significant risk factor for cancer development, as the incidence of most cancers exponentially increases with age (1).
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37 Cancer | Aging & Health A-Z | American Geriatrics Society
https://www.healthinaging.org/a-z-topic/cancer
When cells grow in your body, they divide into exact copies of themselves. But sometimes cells grow abnormally. Often this isn't dangerous, and they grow ...
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38 Associations of DNA methylation algorithms of aging and ...
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00264-X/fulltext
During 17 years of follow-up, a total of 697 malignant tumors (thereof breast cancer = 75, lung cancer = 146, prostate cancer = 114, colorectal ...
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39 Aging, Cancer and Immuno-oncology Program
https://www.sbpdiscovery.org/biomedical-research/programs/aging-cancer-and-immuno-oncology-program
Fundamental changes in our cells and tissues occur with age—and age is a well-recognized risk factor for most adult cancers. These changes to both emergent ...
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40 Aging and Cancer - Moffitt
https://lab.moffitt.org/gomes/research/aging-and-cancer/
In addition to the cancer cell autonomous effects of the aging process, the environment in the aged host is also likely to be at play during tumor progression.
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41 How ageing processes influence cancer
https://rejuvenomicslab.com/wp-content/uploads/2022/01/nrc2013_aging_cancer.pdf
Ageing is the biggest risk factor for cancer; the majority of tumours (in developed coun- tries) are diagnosed in aged patients1,2, and.
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42 Aging-related Gene Signature-Based Model in Breast Cancer
https://www.dovepress.com/an-aging-related-gene-signature-based-model-for-risk-stratification-an-peer-reviewed-fulltext-article-IJWH
Pathologically, it can lead to metabolic disorders, declining immune response and malnutrition, and can induce many chronic diseases, including ...
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43 Cancer and the Aging Population - Oncology Nursing Society
https://www.ons.org/sites/default/files/publication_pdfs/Evidence%20Based%20Practice_Older_Adult_CHAPTER_1.pdf
approaches to the treatment and care of the older adult with cancer. ... of Age and Aging on U.S. Cancer Burden,” by B.K. Edwards, H.L. Howe, L.A. Ries, ...
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44 Preventing aging and cancer in the blood cell system
https://www.jax.org/news-and-insights/2021/october/preventing-aging-and-cancer-in-the-blood-cell-system
It's a fact of life: As we age, mutations happen. The longer we live, the more genetic changes accumulate in our cells.
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45 RFA – Partnership for Aging and Cancer
https://winshipcancer.emory.edu/files/research-files/2022-SWCRF-partnership-for-aging-and-cancer-RFA.pdf
The Samuel Waxman Cancer Research Foundation (SWCRF), in collaboration with the Intramural Programs of the National Cancer Institute (NCI) and National ...
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46 Aging, Cancer and Immunity - Journal of Cancer
https://www.jcancer.org/v10p3021.htm
Cancers are being frequently diagnosed in the elderly. Immunosenescence which refers to the gradual deterioration of the immune system brought on by natural age ...
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47 Cancer and Ageing | Sanofi
https://cancerandageing.eiu.com/
More than half of all new cancer cases occur in those aged 65 and older, and this age group accounts for 70% of cancer deaths.¹ It is therefore incumbent on ...
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48 Cellular Aging and the Development of Cancer
https://cancercommons.org/latest-insights/cellular-aging-and-the-development-of-cancer/
Dr. Bhawe: Cancer is a disease of aging. According to the National Cancer Institute (NCI), cancer incidence increases dramatically after age 50, ...
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49 Abstract 5024: Aging patterns in five disparate cancer entities ...
https://aacrjournals.org/cancerres/article/82/12_Supplement/5024/700651/Abstract-5024-Aging-patterns-in-five-disparate
Human aging is associated with molecular changes and cellular degeneration, resulting in a significant increase in cancer incidence with age ...
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50 Epigenetic Aging Signatures Are Coherently Modified in Cancer
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005334
Aging is associated with highly reproducible DNA methylation (DNAm) changes, which may contribute to higher prevalence of malignant diseases ...
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51 Aging and Cancer: A Complex Relationship - The Scientist
https://www.the-scientist.com/sponsored-webinars/aging-and-cancer-a-complex-relationship-69082
Aging is clearly linked to cancer, as researchers have shown that biological age impacts not only cancer risk and pathogenesis, ...
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52 Aging, Cellular Senescence, and Cancer
https://www.rand.org/content/dam/rand/www/external/labor/aging/rsi/rsi_papers/2013/campisi1.pdf
Cancer, like the age-related degenerative diseases, increases in incidence with nearly expo- nential kinetics beginning at approximately the mid ...
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53 Why does cancer risk increase as we get older? | CTCA
https://www.cancercenter.com/community/blog/2017/02/why-does-cancer-risk-increase-as-we-get-older
Of all of cancer's many riddles and mysteries, one fact remains consistent across almost all types of the disease: The risk of getting ...
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54 Aging and cancer - YouTube
https://www.youtube.com/watch?v=pLQwhZmyicE
Sep 18, 2019
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55 MiRNAs in Aging and Cancer, Volume 334 - 1st Edition
https://www.elsevier.com/books/mirnas-in-aging-and-cancer/galluzzi/978-0-12-811868-9
MiRNAs in Aging and Cancer, Volume 334, the latest in the International Review of Cell and Molecular Biology series, reviews and details current advances in ...
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56 The Most Common Cancers in Older Adults - WebMD
https://www.webmd.com/healthy-aging/the-most-common-cancers-in-older-adults
Certain cancers are more common among older adults. Some of the most common cancers, such as colon cancer and breast cancer, are easy to detect ...
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57 Cellular Senescence: Aging, Cancer, and Injury
https://journals.physiology.org/doi/10.1152/physrev.00020.2018
This phenomenon is currently defined as replicative senescence. Senescent cells can accumulate with age and at sites of age-related pathologies, ...
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58 Aging and cancer: Is glucose a mediator between them?
https://www.oncotarget.com/article/27344/text/
Aging can increase cancer incidence because of accumulated mutations that initiate cancer and via compromised body control of premalignant ...
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59 Telomeres, aging, and cancer: the big picture | Blood
https://ashpublications.org/blood/article/139/6/813/483240/Telomeres-aging-and-cancer-the-big-picture
Differences in average telomere length between humans and cell types help explain differences in the risk of developing cancer and other age- ...
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60 The Center for Cancer and Aging | Icahn School of Medicine
https://icahn.mssm.edu/research/epidemiology/capabilities/center-cancer-aging
Cancer is increasingly a disease of older adults. The aging of the United States population, paired with improved cancer survival, means that a substantial ...
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61 Scientists find that chromosomal abnormalities are associated ...
https://www.genome.gov/27548594/2012-release-scientists-find-that-chromosomal-abnormalities-are-associated-with-aging-and-cancer
"These two studies provide large population-based evidence that genetic mosaicism increases with age and could be a risk factor for cancer. This ...
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62 Study finds a link between aging and cancer metastases
https://www.news-medical.net/news/20220601/Study-finds-a-link-between-aging-and-cancer-metastases.aspx
Age-related changes in the skin microenvironment suppressed the growth of melanoma cells but drove their dissemination, seeding the deadly ...
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63 Normal Aging and Its Role in Cancer Metastasis
http://perspectivesinmedicine.cshlp.org/content/10/9/a037341.full.pdf
Aging is a key prognostic factor in many cancers. Emerging data suggest that normal age-related changes in the tumor microenvironment can contribute to ...
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64 DNA Damage, Aging, and Cancer
https://www.nejm.org/doi/pdf/10.1056/NEJMra0804615
DNA damage has emerged as a major culprit in cancer and many diseases related to aging. The stability of the genome is supported by an.
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65 Aging and Cancer Effects (ACE) Study - Full Text View
https://clinicaltrials.gov/ct2/show/NCT00204880
Aging and Cancer Effects (ACE) Study. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
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66 Hollings research finds new link between aging, cancer and ...
https://hollingscancercenter.musc.edu/news/archive/2021/06/02/hollings-research-sheds-light-on-connection-between-aging-cancer-mitochondrial-function-t-cells
MUSC Hollings Cancer Center researchers are finding solutions to the aging-related changes that reduce anti-cancer immunity.
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67 Why Does Cancer Risk Increase As We Get Older? - Blog
https://blog.dana-farber.org/insight/2016/06/why-does-cancer-risk-increase-as-we-get-older/
Age is the biggest single risk factor for cancer. Risk increases significantly after age 50, and half of all cancers occur at age 66 and ...
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68 When Cancer Grows Old - Sanofi
https://www.sanofi.com/en/your-health/specialty-care/oncology/when-cancer-grows-old
Our When Cancer Grows Old™ initiative addresses the challenges of cancer and aging. We collaborate with the global cancer community, including advocates and ...
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69 Cancer and Aging: Two Tightly Interconnected Biological ...
https://pdfs.semanticscholar.org/f2c1/e70695bfbeaf0b871b130890afe5e12c1485.pdf
connections between aging and cancer, as well as aging biomarkers that could be useful in the field of geriatric oncology.
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70 Tumors differ depending on age of cancer patients
https://news.cornell.edu/stories/2021/12/tumors-differ-depending-age-cancer-patients
There is a strong association between aging and developing cancer. Recently, there has also been a rise in the incidence of cancer among young ...
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71 WRN at telomeres: implications for aging and cancer
https://journals.biologists.com/jcs/article/120/5/713/34376/WRN-at-telomeres-implications-for-aging-and-cancer
Werner Syndrome (WS) is a premature aging syndrome characterized by early onset of age-related pathologies and cancer. Since WS is due to a ...
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72 How Senescent Cells Spur Aging and Cancer
https://www.scientificamerican.com/article/how-senescent-cells-spur-aging-cancer/
Recent research indicates that the cells can contribute to aging in the originally proposed way and also by spurring inflammation. Plus, they ...
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73 New thinking on the process of ageing
https://cancergrandchallenges.org/news/new-thinking-process-ageing
The theory proposes this build-up of mutations over time impacts the function of genes and disturbs cell function, ultimately leading to age- ...
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74 Individual Aging and Cancer Risk: How are They Related?
https://www.demographic-research.org/volumes/vol9/8/
This increase is in agreement with common theories of aging, such as mutation accumulation, wear and tear, antagonistic pleiotropy, etc.
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75 Aging and smoking named the 2 biggest risk factors for all ...
https://studyfinds.org/aging-smoking-risk-factors-cancer/
Researchers at the American Cancer Society say aging and smoking are the two most important risk factors when determining a person's ...
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76 Aging and cancer - Longevity Wiki
https://en.longevitywiki.org/wiki/Aging_and_cancer
Cancer is regarded as an age-related disease. While many exceptions exist, such as childhood cancers typically associated with monogenic ...
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77 Aging and cancer: are sirtuins the link? | Future Oncology
https://www.futuremedicine.com/doi/10.2217/fon.10.57
The loss of function caused by degeneration limits the maximum lifespan of all organisms and is linked to disease and cancer. Nevertheless, the ...
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78 Cancer Risk Associated With Key Epigenetic Changes ...
https://www.hopkinsmedicine.org/news/newsroom/news-releases/cancer-risk-associated-with-key-epigenetic-changes-occurring-through-normal-aging-process
Some scientists have hypothesized that tumor-promoting changes in cells during cancer development—particularly an epigenetic change involving ...
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79 Aging and breast cancer | Research UC Berkeley
https://vcresearch.berkeley.edu/news/aging-and-breast-cancer
Age-related physiological changes, including endocrine profiles and alterations of the microenvironments surrounding breast cells, have been ...
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80 Models to Combat Cancer & Aging (MCCA)
https://www.combatcancerandaging.nl/
With our innovative research and high-tech facilities, the MCCA consortium wants to better understand the underlying biology that drives aging and cancer.
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81 The Importance of Mitochondrial DNA in Aging and Cancer
https://www.hindawi.com/journals/jar/2011/407536/
Mitochondrial dysfunction has been implicated in premature aging, age-related diseases, and tumor initiation and progression.
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82 Age and Cancer Risk - American Journal of Preventive Medicine
https://www.ajpmonline.org/article/S0749-3797(13)00642-9/fulltext
Midlife is a period of life when the prevalence of multiple cancer risk factors is high and incidence rates begin to increase for many types of ...
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83 Aging: How Growing Older Affects Cancer Risk and Outcomes
https://www.newswise.com/articles/aging-how-growing-older-affects-cancer-risk-and-outcomes
As our population ages and senior citizens become a larger demographic, cancer researchers are focusing on the links between aging and cancer.
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84 Onco-Aging - EUniWell
https://www.euniwell.eu/what-we-offer/seed-funding-programme/projects-of-the-first-seed-funding-call/onco-aging
The incidence of cancer increases proportionally with age, especially in the regions of the European Union. Furthermore, many of the most common types of ...
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85 Cancer, Aging and the Importance of the Tumor ...
https://www.technologynetworks.com/cancer-research/videos/cancer-aging-and-the-importance-of-the-tumor-microenvironment-349475
Technology Networks
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86 Pediatric Cancer Survivors Experience Premature Aging
https://www.cancertherapyadvisor.com/home/cancer-topics/pediatric-cancer/pediatric-cancer-survivors-experience-premature-aging/
The study showed that cancer survivors had an increased accumulation of aging-related deficits. For example, a 30-year-old cancer survivor had ...
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87 Aging-Associated Cancers
https://reference.jrank.org/aging/AgingAssociated_Cancers.html
Advancing age is the most important risk factor for cancer overall, and for many individual cancer types. According to statistical data from National Cancer ...
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88 High Sugar Intake May Lead to Premature Aging in Childhood ...
https://www.curetoday.com/view/high-sugar-intake-may-lead-to-premature-aging-in-childhood-cancer-survivors
Childhood cancer survivors who had high daily sugar intake — especially ... aging-related health complications, according to recent research.
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89 Geriatric Oncology - Association of Community Cancer Centers
https://www.accc-cancer.org/home/learn/supportive-care/geriatric
The number of Americans age 65 and older is projected to nearly double from 52 million in 2018 to 95 million in 2060, bringing the 65-and-older age group ...
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90 Prostate cancer - Symptoms and causes - Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/prostate-cancer/symptoms-causes/syc-20353087
While it is small, it has an important role in reproductive health and can cause voiding or urinary symptoms as men age, as well becoming a ...
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91 Study Shows that HIV-positive Patients with Cancer may Have ...
https://www.oncozine.com/study-shows-that-hiv-positive-patients-with-cancer-may-have-accelerated-biological-aging/
A new study suggests that patients diagnosed with cancer who were living with HIV infection, have an increased epigenetic age—a type of ...
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92 Cancer study: Cases on the rise globally for those under age ...
https://www.usatoday.com/story/news/health/2022/09/07/cancer-study-cases-rise-globally-those-under-age-50/8010847001/
The median age for a cancer diagnosis is 66, according to the National Cancer Institute. Certain cancer risk factors including "highly processed ...
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93 Cancer in later life - Age UK
https://www.ageuk.org.uk/our-impact/campaigning/cancer-in-later-life/
Cancer is primarily a disease of older people ... By 2020, there will be 2m people aged 65 and over alive following a diagnosis of cancer. The ...
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94 Geriatric Assessment Intervention Helps Reduce Symptom ...
https://www.oncnursingnews.com/view/geriatric-assessment-intervention-helps-reduce-symptom-burden-for-older-patients-with-advanced-cancer
More than a quarter of new cancer diagnosis are for patients who are 75 years and older. Unfortunately, this patient population is typically ...
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