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1 Mutation accumulation theory - Wikipedia
https://en.wikipedia.org/wiki/Mutation_accumulation_theory
The mutation accumulation theory of ageing was first proposed by Peter Medawar in 1952 as an evolutionary explanation for biological ageing and the associated ...
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2 Evolution, Chance, and Aging - Frontiers
https://www.frontiersin.org/articles/10.3389/fgene.2021.733184/full
The mutation accumulation theory proposes the random accumulation of mutations that negatively affect older organisms, leading to increased ...
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3 Accumulative Waste Theory of Aging | SpringerLink
https://link.springer.com/10.1007%2F978-0-387-33754-8_6
There are several mechanisms by which garbage accumulation affects cells. The presence of waste products changes the structural organization of the cell.
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4 A test of evolutionary theories of aging - PMC - NCBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137876/
The two leading theories posit that aging is due to (i) pleiotropic genes with ... Under the mutation accumulation (MA) theory, alleles with purely ...
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5 Mutation Accumulation Theory of Aging
http://www.programmed-aging.org/theories/mutation_accumulation.html
The mutation accumulation theory is based on Medawar's Hypothesis, which suggests that the evolutionary effect of adverse events declines following the age ...
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6 Accumulation Theory - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/social-sciences/accumulation-theory
The oldest evolutionary theory of aging still widely accepted is the theory of mutation accumulation, first proposed by Sir Peter Medawar (Medawar, 1952).
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7 The Evolution of Aging | Learn Science at Scitable - Nature
https://www.nature.com/scitable/knowledge/library/the-evolution-of-aging-23651151/
Such late-life deleterious genetic variants can lead to the evolution of aging, an idea called the mutation accumulation (MA) theory of aging.
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8 MUTATION ACCUMULATION THEORY
https://awarnach.mathstat.dal.ca/~joeb/biol3046/projects/AGE2/Mutation%20accumulation%20theory.htm
Peter Medawar suggested that ageing is a by-product of accumulation of deleterious mutations over time. Due to stochastic risk of accident, ...
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9 [1505.07016] Misrepair accumulation theory - arXiv
https://arxiv.org/abs/1505.07016
Misrepair-accumulation theory: a theory for understanding aging, cancer- development, longevity, and adaptation. Jicun Wang-Michelitsch1*, Thomas M ...
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10 Evolution of Aging - Mutation Accumulation Theory Of Aging
https://medicine.jrank.org/pages/608/Evolution-Aging-Mutation-accumulation-theory-aging.html
The mutation accumulation theory of aging, suggested by Peter Medawar in 1952, considers aging as a by-product of natural selection (similar to the ...
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11 New thinking on the process of ageing
https://cancergrandchallenges.org/news/new-thinking-process-ageing
The theory proposes this build-up of mutations over time impacts the function of genes and disturbs cell function, ultimately leading to age- ...
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12 Theories of Ageing - Physiopedia
https://www.physio-pedia.com/Theories_of_Ageing
The Free Radical Theory: Implicates the gradual accumulation of oxidative cellular damage as a fundamental driver of cellular aging. · Error theory · The Cross- ...
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13 Aging as a Process of Deficit Accumulation: Its Utility and Origin
https://www.karger.com/Article/Fulltext/364933
Aging can be conceptualized as a process of the accumulation of deficits, taking place in different individuals in different ways, with a ...
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14 Garbage catastrophe theory of aging: imperfect removal of ...
https://www.tandfonline.com/doi/pdf/10.1179/135100001101535996
Life is associated with progressive accumulation of dele- terious changes, the summation of which is called aging. (senescence).
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15 Testing the Mutation Accumulation Theory of Aging Using ...
https://www.scirp.org/journal/paperinformation.aspx?paperid=82976
The mutation Accumulation Theory of Aging proposes that random mutations with aging underlie, to some extent, the aging phenotype; here three proteins were ...
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16 (PDF) Misrepair accumulation theory - ResearchGate
https://www.researchgate.net/publication/277334300_Misrepair_accumulation_theory_a_theory_for_understanding_aging_cancer_development_longevity_and_adaptation
Misrepair accumulation theory is a novel theory in interpreting aging phenomena. With a new concept of Misrepair, this theory reaches a ...
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17 Why we age – new theories gaining ground - The Conversation
https://theconversation.com/why-we-age-new-theories-gaining-ground-124219
One of the oldest theories of ageing is the damage-accumulation theory, proposed by August Weisman in 1882. Cells and organisms are complex ...
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18 Evolution of ageing - bionity.com
https://www.bionity.com/en/encyclopedia/Evolution_of_ageing.html
Medawar's theory is referred to as Mutation Accumulation. The mechanism of action involves random, detrimental mutations of a kind that happen to show their ...
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19 Understanding the Odd Science of Aging - Cell Press
https://www.cell.com/fulltext/S0092-8674(05)00101-7
Medawar's idea, now known as the “mutation accumulation” theory, proposed that late-acting alleles arising by de novo germline mutation could, at best, be acted ...
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20 The Accumulation Theory of Ageing - NASA/ADS
https://ui.adsabs.harvard.edu/abs/arXiv:1110.2993
The Accumulation Theory of Ageing ... Abstract. Lifespan distributions of populations of quite diverse species such as humans and yeast seem to surprisingly well ...
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21 Mutation accumulation differentially impacts ageing ... - bioRxiv
https://www.biorxiv.org/content/10.1101/247700v1.full.pdf
Medawar's mutation accumulation (MA) hypothesis explains ageing by the declining force of natural selection with age: slightly deleterious ...
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22 Mutation Accumulation May Be a Minor Force in Shaping Life ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034146
Following the basic corollary of mutation accumulation theory (genes responsible for senescence have age-specific effects on fertility and ...
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23 Damage-Based Theories of Aging - Senescence.info
https://www.senescence.info/causes_of_aging.html
Taken together, results from progeroid syndromes in mice and man support the DNA damage theory of aging. One hypothesis is that DNA damage accumulation with age ...
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24 Theories and Mechanisms of Aging - Thoracic Key
https://thoracickey.com/theories-and-mechanisms-of-aging/
This group of theories focuses on aging as a consequence of the accumulation of cellular components or specific cell types with altered ...
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25 THEORIES OF AGING
https://www.afar.org/imported/AFAR_INFOAGING_GUIDE_THEORIES_OF_AGING_2016.pdf
aging info guides. THEORIES OF AGING. An introduction to aging science ... 2 | Infoaging Guide to Theories of Aging ... mutation accumulation theory.
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26 New Data Supports Mutation Accumulation Theory of Aging ...
https://www.labmedica.com/bioresearch/articles/73070000/new-data-supports-mutation-accumulation-theory-of-aging.html
A recent study has yielded data supporting the mutation accumulation (MA) theory of aging, a theory that attributes the aging process to the accumulation of ...
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27 Stochastic modeling of aging cells reveals how damage ...
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-019-2921-3
Even though the somatic cells of multicellular organisms accumulate significant amounts of aging-related damage throughout the lifetime of the ...
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28 Theories of Aging - Jones & Bartlett Learning
https://samples.jbpub.com/9781284104479/Chapter_3.pdf
For example, there are specific programmed events in the life of a cell, but cells also accumulate genetic damage to the mitochondria due to free radicals and ...
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29 Mutation Accumulation - YouTube
https://www.youtube.com/watch?v=PIg46kDHQh8
BiologyasPoetry
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30 Theories of Aging | Biology of Aging - Lumen Learning
https://courses.lumenlearning.com/atd-herkimer-biologyofaging/chapter/why-the-body-ages/
Life span is the key to the intrinsic biological causes of aging, as these factors ensure an individual's survival to a certain point until biological ageing ...
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31 Untitled - Cedar Creek Ecosystem Science Reserve - University of ...
https://www.cedarcreek.umn.edu/biblio/fulltext/t2114.pdf
theory of aging as an explanation for the extreme longevity of the little ... evolutionary theories of aging exist-the mutation accumulation theory, the.
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32 Traditional aging theories: which ones are useful? - Archive ouverte ...
https://hal.archives-ouvertes.fr/hal-01134912/document
Aging, aging theories, deductive analysis of impossibility, evolvability theory, mutation- accumulation theory, antagonistic pleiotropy theory, ...
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33 aging - Nongenetic theories - Encyclopedia Britannica
https://www.britannica.com/science/aging-life-process/Nongenetic-theories
A corollary to the wear-and-tear theory is the presumption that waste products accumulate within cells and interfere with function. The accumulation of highly ...
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34 Waste Accumulation Theory of Aging - H+Pedia
https://hpluspedia.org/wiki/Waste_Accumulation_Theory_of_Aging
The disposable soma theory of aging states that organisms age due to an evolutionary trade-off between growth, reproduction, and DNA repair ...
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35 Testing the “garbage” accumulation theory of ageing: mitotic activity ...
https://www.semanticscholar.org/paper/Testing-the-%E2%80%9Cgarbage%E2%80%9D-accumulation-theory-of-cells-Stroikin-Dalen/703a338efa3aed19fd794e8dfb95f92be4e710fa
The results support a key role of biological lysosomal “garbage” accumulation in the triggering of ageing and death of postmitotic cells, as well as the ...
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36 Theories of Biological Aging: Error Catastrophe
https://www.encyclopedia.com/education/encyclopedias-almanacs-transcripts-and-maps/theories-biological-aging-error-catastrophe
This escalating process could turn what is initially a very low error rate in young individuals into a significant rate of accumulation of errors in older ...
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37 Aging: progressive decline in fitness due to the rising ...
https://onlinelibrary.wiley.com/doi/10.1111/acel.12480
The evolutionary theory of aging, with its key concepts of mutation accumulation (MA) (Medawar, 1952) and antagonistic pleiotropy (AP) ...
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38 The Wear-and-Tear Theory of Aging - Verywell Health
https://www.verywellhealth.com/wear-and-tear-theory-of-aging-2224235
The wear-and-tear theory of aging asserts that the effects of aging are caused by progressive damage to cells and body systems over time.1 ...
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39 Evolution ofsenescence under positive pleiotropy? - DiVA portal
https://www.diva-portal.org/smash/get/diva2:809449/FULLTEXT01.pdf
Patterns of age-specific means and genetic variances of mortality rates predicted by the mutation-accumulation theory of ageing. J Theor Biol 210: 47-65. 9.
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40 A mini-review of the evolutionary theories of aging
https://www.demographic-research.org/volumes/vol4/1/4-1.pdf
More experiments have tried to experimentally test the antagonistic pleiotropy theory than the theory of accumulation of mutations at old age, ...
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41 Lipofuscin and Aging: A Matter of Toxic Waste - Science
https://www.science.org/doi/10.1126/sageke.2005.5.re1
The nearly linear accumulation of lipofuscin with increasing age in the nervous systems of creatures in the wild has made possible the reliable estimation of ...
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42 DNA damage—how and why we age? - eLife
https://elifesciences.org/articles/62852
Many factors contribute to aging, such as the time-dependent accumulation of macromolecular damage, including DNA damage. The integrity of the ...
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43 Theories on Aging - SPH - Boston University
https://sphweb.bumc.bu.edu/otlt/mph-modules/ph/aging/aging3.html
First, senescent cells in tissues may accumulate to the point where the strength and functional capacity of tissues in compromised. A second ...
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44 Is antagonistic pleiotropy ubiquitous in aging biology?
https://academic.oup.com/emph/article/2018/1/287/5126836
Medawar's insight was in realizing that the same logic could also be applied to aging. ... This concept/idea is referred to as Medawar's mutation accumulation ...
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45 Conceptual Models of Frailty
https://frailtyscience.org/conceptual-models-frailty
Rockwood's Cumulative Deficit Theory (2001): Frailty is the result of an aging process in which the accumulation of age-related deficits across domains of ...
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46 Evolutionary Theories of Aging and Longevity - Hindawi.com
https://downloads.hindawi.com/journals/tswj/2002/704240.pdf
The main difference between the two theories is that in the mutation accumulation theory, genes with negative effects at old age accumulate ...
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47 what is the mutation accumulation theory of aging? - Quizlet
https://quizlet.com/question/what-is-the-mutation-accumulation-theory-of-aging-5762435128512588883
What is the Mutation Accumulation Theory of aging? Suggests that detrimental, late-acting mutations may accumulate in the population and ultimately lead to ...
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48 Invited Review: Theories of aging | Journal of Applied ...
https://journals.physiology.org/doi/full/10.1152/japplphysiol.00288.2003
The Somatic Mutation Theory of aging supposes that accumulation of genetic mutations in somatic cells is the specific cause of senescence; free radical damage ...
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49 Aging Attributed to Hyperfunction, Not Accumulation of ...
https://www.genengnews.com/topics/omics/aging-attributed-to-hyperfunction-not-accumulation-of-molecular-damage/
The hyperfunction theory, an alternative idea that has emerged in biogerontology in recent years, allows that molecular damage does occur. The ...
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50 An emerging paradigm for the biology of aging
https://www.ucl.ac.uk/~ucbtdag/Gems_2022.pdf
This instantiates the mutation accumulation theory of the evolution of aging. (Medawar, 1952). Here, the harmful alleles that natural selection ...
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51 Revamping the evolutionary theories of aging - ClinicalKey
https://www.clinicalkey.fr/#!/content/journal/1-s2.0-S1568163719301321#refInSitubib1000
The classical mutation accumulation, antagonistic pleiotropy, and disposable soma theories predict that increased extrinsic mortality should select for the ...
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52 Evolution of ageing as a tangle of trade-offs: energy versus ...
https://royalsocietypublishing.org/doi/10.1098/rspb.2019.1604
Antagonistic pleiotropy: is the evolutionary theory of ageing which recognizes that genes often have multiple or pleiotropic effects and that a ...
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53 Antagonistic pleiotropy and mutation accumulation contribute ...
https://www.jstor.org/stable/48576470
and AP theories of aging in the age-related decline in stress tolerance. ... Drosophila genetic reference panel, mutation accumulation, senescence, ...
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54 wear-and-tear theory of aging - APA Dictionary of Psychology
https://dictionary.apa.org/wear-and-tear-theory-of-aging
a theory of biological aging suggesting that aging results from an accumulation of damage to cells, tissues, and organs in the body caused by dietary toxins ...
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55 What Do We Mean by Accumulation? Advancing ... - Scinapse
https://asset-pdf.scinapse.io/prod/2292041291/2292041291.pdf
Beyond empirical investigations, many theories or models of aging make accumulation (or de-accumulation) a central concept: somatic mutation theory of aging ...
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56 Ageing is due to accumulation of harmful proteins. The theory is
https://www.toppr.com/ask/question/ageing-is-due-to-accumulation-of-harmful-proteins-the-theory/
Ageing is due to accumulation of harmful proteins. The theory is · Free radical · Cross-linking · Error catastrophe · Cross linking · A. Free radical theory - ging ...
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57 The Disposable Soma Theory (Chapter 2) - The Evolution of ...
https://www.cambridge.org/core/books/evolution-of-senescence-in-the-tree-of-life/disposable-soma-theory/4A3E5C0981243B9529C55BAFC39E72B0
For the mutation accumulation theory, the decline in survivorship means that by an age when very few individuals remain alive, the force of selection is too ...
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58 Alzheimer's disease –mechansims-cause-factors-prevalence
http://www.aginganddisease.org/EN/article/downloadArticleFile.do?attachType=PDF&id=147252
new aging theories, it may be possible to promote successful aging. Key words: Aging; Biological; ... According to this theory, an accumulation of cross-.
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59 Why we age – new theories gaining ground - Yahoo News
https://ph.news.yahoo.com/why-age-theories-gaining-ground-131237515.html
One of the oldest theories of ageing is the damage-accumulation theory, proposed by August Weisman in 1882. Cells and organisms are complex systems with ...
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60 THEORIES OF AGING
https://ogg.osu.edu/media/documents/sage/course1/ppt/theories_of_aging.ppt
Biologic Theories: Divisions. Stochastic: Explain aging as events that occur randomly and accumulate over time. Nonstochastic: View aging as certain ...
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61 Social Structure of Accumulation Theory and Analysis
https://economics.ucr.edu/wp-content/uploads/2019/11/VictorLippit10-20-06.pdf
It is of interest to note that these institutional changes came prior to the postwar "golden age," but having them in place helped to secure a stable financial ...
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62 Aging - Amazon AWS
https://rstudio-pubs-static.s3.amazonaws.com/676552_4bc7a489b19345a68c41eb8644e2a98a.html
DEF: Aging is the result of fundamental limitations, inevitable small random changes that accumulate with time (stochastic theories of ...
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63 BASICS OF AGING THEORIES AND DISEASE RELATED ...
https://www.pharmatutor.org/articles/basics-of-aging-theories-and-disease-related-aging-an-overview
This is based on the idea that changes associated with aging result from damage by chance that accumulates over time. The wear-and-tear theories ...
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64 Why Do We Age, and Can Anything Be Done to Stop or Slow it?
https://www.healthline.com/health/why-do-we-age
Programmed aging theories say that people are designed to age and that our cells have a predetermined lifespan that's encoded into our bodies.
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65 Cellular secrets of ageing unlocked by researchers
https://www.sanger.ac.uk/news_item/cellular-secrets-of-ageing-unlocked-by-researchers/
All human cells acquire genetic changes throughout life, known as somatic mutations. Ageing is likely to be caused by the accumulation of ...
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66 Theories of Aging & Death - Video & Lesson Transcript
https://study.com/academy/lesson/theories-of-aging-and-death-programmed-theories-vs-damage-theories.html
The wear and tear theory of aging emphasizes external environmental factors that damage cells and lead to aging. The accumulation of damage ...
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67 Understanding Cross Linking & Other Theories of Aging
https://www.heartoftexaseye.com/blog/cross-linking-theories-of-aging/
The third commonly referenced philosophy in relation to aging is the continuity theory of aging. This theory states that as people age, they ...
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68 [PDF] Mutation Accumulation Aging Theory by Laurence D. Mueller ...
https://oa.mg/work/10.1007/978-3-030-22009-9_48
Mueller, L. D. (2021). Mutation Accumulation Aging Theory. https://doi.org/10.1007/978-3-030-22009-9_48. Powered by Citationsy*.
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69 Theories of Aging | HealthPlexus.net
https://www.healthplexus.net/article/theories-aging
A contemporary (1950s) evolutionary theory offered by P.B. Medawar known as the mutation accumulation theory (1952) described aging not as adaptive but as a ...
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70 Mutation accumulation theory - IVAO
http://www.ivao.com/en/anti-aging/teorii-stareniya/teoriya-nakopleniya-mutatsiy/
The sense of the theory is following: genes with harmful mutations exhibiting in old age does not meet any significant resistance of the natural selection, ...
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71 Physiological aging | Psychology Wiki - Fandom
https://psychology.fandom.com/wiki/Physiological_aging
Peter Medawar formalised this observation in his mutation accumulation theory of ageing. "The force of natural selection weakens with increasing age — even ...
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72 DNA damage theory of aging - wikidoc
https://www.wikidoc.org/index.php/DNA_damage_theory_of_aging
In tissues composed of non- or infrequently replicating cells, DNA damages can accumulate with age and lead either to loss of cells, or, in ...
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73 Theory and Evidence from Denmark | NBER
https://www.nber.org/papers/w24371
Using administrative wealth records from Denmark, we study the effects of wealth taxes on wealth accumulation. Denmark used to impose one of ...
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74 Molecular footprint of Medawar's mutation ... - OpenMETU
https://open.metu.edu.tr/handle/11511/43192
Medawar's mutation accumulation hypothesis explains aging by the declining force of natural selection with age: Slightly deleterious germline mutations ...
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75 mutations are strongly sclected against Iate In Iife only if they ...
https://www.numerade.com/ask/question/the-mutation-accumulation-hypothesis-of-ageing-proposes-that-senescence-occurs-iate-in-ilfe-because-mutations-are-strongly-sclected-against-iate-in-iife-only-if-they-are-lethal-bence-they-ac-04733/
VIDEO ANSWER: Hi this question is asking about the mutation accumulation hypothesis of aging. Um and why we see this occurring later in life ...
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76 Oxidative Stress, the Damage- Accumulation Theory of Skin ...
https://cdn.mdedge.com/files/s3fs-public/Document/September-2017/022110576.pdf
Oxidative Stress, the Damage-. Accumulation Theory of Skin. Aging, and the Role of. Antioxidants in the Future of Topical Skin Protection.
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77 Cellular aging: theories and technological influence - SciELO
https://www.scielo.br/j/babt/a/JwhY4xGwV4VDqnWJKcZWp4x/
But, as these errors accumulate, this theory also blames the reserve genetic sequences of identical DNA that take over until the system is worn out. Dr. Zhores ...
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78 "ERC Accumulation and Premature Aging: An Investigation of ...
https://scholarship.claremont.edu/pomona_theses/119/
When yeast divides, it ages a generation, while daughter cells begin life at generation zero. One theory surrounding this process in yeast is the ...
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79 The Penna Model of Biological Aging - D. Stauffer, 2007
https://journals.sagepub.com/doi/10.1177/117793220700100005
... simulation of biological aging, particularly with the Penna model of 1995. They are based on the mutation accumulation theory of half a century ago.
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80 Holdings: Aging as a process of accumulation of Misrepairs
https://ebusca.uv.mx/Record/oai-cd%20ararXiv.org-cd%20ar1503.07163
We recently introduced Misrepair-accumulation theory as an interpretation on aging mechanism. For better understanding this theory, we discuss here in more ...
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81 Mechanisms of Aging and the Preventive Effects of ... - MDPI
https://www.mdpi.com/1420-3049/25/20/4649
Cellular senescence has some physiological benefits, such as repressing tumorigenesis; however, excessive accumulation of senescent cells exacerbates the ...
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82 Mutation accumulation and the catastrophic senescence of the ...
https://link.aps.org/doi/10.1103/PhysRevE.52.R3309
... and at a fixed age is the only ingredient needed to explain the catastrophic senescence according to the mutation accumulation theory.
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83 Cellular secrets of aging unlocked by researchers
https://www.sciencedaily.com/releases/2022/06/220601111729.htm
All human cells acquire genetic changes throughout life, known as somatic mutations. Ageing is likely to be caused by the accumulation of ...
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84 The role of mitochondria in aging - JCI
https://www.jci.org/articles/view/64125
A number of aging theories have been proposed (1–5), and the mitochondrial ... with age, (c) mutations of mitochondrial DNA (mtDNA) accumulate during aging, ...
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85 Springer MRW: [AU:, IDX:]
http://www.r-site.org/ageing/encyclopedia/libertini_2019_non_evol_and_evol_aging_theories.pdf
The distinction in two groups of aging theories, ... A different theory interpreted aging as a con- ... Mutation accumulation hypothesis. In 1952,.
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86 Alleles and Longevity - University of California, Berkeley
https://u.demog.berkeley.edu/~wachter/alto.pdf
The Present State of Mutation Accumulation Theory and Genomic. Observations. Kenneth W. Wachter ... Demography of Aging (Ron Lee, Director).
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87 Aging: damage accumulation versus increasing mortality rate
https://www.demogr.mpg.de/papers/working/wp-2005-018.pdf
really describe aging? In fact, this is a matter of a defi- nition: in reliability theory (Barlow and Proschan, 1975), e.g., the simplest and most.
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88 What Are the Different Theories of Aging? - spermidineLIFE® US
https://spermidinelife.us/blogs/news/what-are-the-different-theories-of-aging
Damage Accumulation Theory - This theory suggests that their ability to repair damaged DNA declines as people age.
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89 Cellular aging - ThaiJo
https://he02.tci-thaijo.org/index.php/tmj/article/download/15698/14334/33921
theories. A wide range of aging causes can be classified into four major groups: free radicals, glycation, telomere shortening, and accumulation of toxic ...
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90 Encyclopedia of Aging and Public Health
https://books.google.com/books?id=rTMrB0AutLwC&pg=PA74&lpg=PA74&dq=accumulation+theory+aging&source=bl&ots=V0S4wFrHjK&sig=ACfU3U0pTLycOQ2L1jJb6Bsb3nSqB9uSiw&hl=en&sa=X&ved=2ahUKEwi9pJHYluD7AhV4ElkFHRNUASkQ6AF6BQjmAhAD
Jessica Diggs The accumulative waste theory of aging, also known as the waste accumulation or garbage accumulation theory of aging, proposes that molecules ...
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91 3.1 Biological Theories of Aging - Revel Content Player
https://revelpreview.pearson.com/epubs/pearson_hooyman_kawamoto_kiyak/OPS/s9ml/chapter03/filep70004914910000000000000000074cc.xhtml
However, a more accurate conception of the aging process is a gradual accumulation of irreversible functional losses to which the average person adapts—often in ...
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92 Aging Theories - SlideShare
https://www.slideshare.net/hmirzaeee/aging-theories
23. 6) Clinker Theories • Potentially harmful substances accumulate in the body over the years • One substance that has been identified is ...
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